Revue Francaise d Allergologie最新文献_第4页

Discovery of inflammatory response-related proteins as candidate urinary biomarkers of allergic rhinitis 发现作为过敏性鼻炎候选尿液生物标记物的炎症反应相关蛋白

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-10-09 DOI: 10.1016/j.reval.2024.104160

N. Liu , J. Wang , M. Zhang

{"title":"Discovery of inflammatory response-related proteins as candidate urinary biomarkers of allergic rhinitis","authors":"N. Liu , J. Wang , M. Zhang","doi":"10.1016/j.reval.2024.104160","DOIUrl":"10.1016/j.reval.2024.104160","url":null,"abstract":"<div><h3>Objectives</h3><div>Allergic rhinitis (AR) is a pervasive condition, affecting a significant global population, often with lifelong implications. The objective of this study is to screen for inflammatory-related differential proteins in the urine of AR patients, aiming to analyze the correlation between these identified proteins and the severity of allergic rhinitis.</div></div><div><h3>Design and methods</h3><div>To diagnose AR, we utilized the sIgE test to measure the allergenic responses. Based on the total IgE levels, patients were segregated into two categories: AR1 (IgE>125IU/mL) and AR2 (IgE≤125IU/mL). The differential proteins related to inflammation in the urine of patients were screened using TMT labeling combined with LC–MS/MS. Subsequently, these proteins were validated through PRM-based proteomics quantification.</div></div><div><h3>Results</h3><div>We found significant increases in FCGR3A, A1AT, KRT18, and IL18 in the AR group (<em>P</em>  <!-->0.001). PRM-based quantification results highlighted considerable differences in the concentrations of these four proteins across varying degrees of allergic rhinitis severity. A biomarker panel comprising FCGR3A, A1AT, KRT18, and IL18 was identified, with an area under the curve (AUC) value of 0.993 for the detection of AR.</div></div><div><h3>Conclusions</h3><div>This study provides the first comprehensive report of combined TMT labeling LC–MS/MS quantitative proteomics and PRM analysis for discovering urinary biomarkers related to inflammatory responses in AR. These findings may be instrumental in evaluating the severity of allergic rhinitis and further our understanding of the molecular mechanisms underlying AR.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104160"},"PeriodicalIF":0.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug reaction with eosinophilia and systemic symptoms: Analysis of cutaneous phenotype as a prognosis factor 伴有嗜酸性粒细胞增多和全身症状的药物反应：作为预后因素的皮肤表型分析

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-09-20 DOI: 10.1016/j.reval.2024.104161

G. Sqalli-Houssini , Z. Douhi , M. Soughi , S. Elloudi , H. Baybay , B. Moukafih , M. Omari , K. El Rhazi , F.Z. Mernissi

{"title":"Drug reaction with eosinophilia and systemic symptoms: Analysis of cutaneous phenotype as a prognosis factor","authors":"G. Sqalli-Houssini , Z. Douhi , M. Soughi , S. Elloudi , H. Baybay , B. Moukafih , M. Omari , K. El Rhazi , F.Z. Mernissi","doi":"10.1016/j.reval.2024.104161","DOIUrl":"10.1016/j.reval.2024.104161","url":null,"abstract":"<div><h3>Study objective</h3><p>The DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is a severe and potentially fatal toxidermia due to various visceral involvements. Identifying factors predisposing to serious complications is essential for clinical and therapeutic management. This study aims to analyze the cutaneous presentation of DRESS and its role as a prognostic factor.</p></div><div><h3>Patients and methods</h3><p>This is a retrospective, descriptive, and analytical study conducted over nine years at the dermatology department in Fes, including all hospitalized DRESS cases.</p></div><div><h3>Results</h3><p>The maculopapular rash was the most frequent phenotype (49.3%), followed by erythroderma, morbilliform exanthem, and polymorphous erythema-like rash. In all, 52.8% of patients had renal involvement and 45.8% had hepatic involvement, while 81.9% exhibited hypereosinophilia. The maculopapular rash and erythroderma were more associated with internal organ involvement, although no significant statistical correlation could be demonstrated. Allopurinol was the most implicated drug in 51.4% of the cases. No correlation was found between the type of medication and the cutaneous presentation. In all, 8.3% of the patients died, primarily those with erythroderma (15.8%).</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that maculopapular rash and erythroderma are the most common presentations and are most associated with internal organ complications, with a more unfavorable prognosis for erythrodermic cases.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104161"},"PeriodicalIF":0.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142270729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enfant présentant une allergie alimentaire en crèche : quelle est la place du Projet d’Accueil Individualisé ? Quels ressentis pour le personnel ? 托儿所中食物过敏的儿童："个性化欢迎计划 "的作用是什么？工作人员的感受如何？

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-08-24 DOI: 10.1016/j.reval.2024.104138

Amélie Thong Buisson

{"title":"Enfant présentant une allergie alimentaire en crèche : quelle est la place du Projet d’Accueil Individualisé ? Quels ressentis pour le personnel ?","authors":"Amélie Thong Buisson","doi":"10.1016/j.reval.2024.104138","DOIUrl":"10.1016/j.reval.2024.104138","url":null,"abstract":"<div><h3>Context</h3><p>The nursery welcomes children from a few months to the age of 3 years, age range where there is an increase in cases of anaphylaxis related to food allergies (FA).</p></div><div><h3>Objectives</h3><p>To draw up an inventory of the training and knowledge of staff with regard to FA. Observe the organization of the Individualized Reception Project (IRP) in the nursery. Take stock of the feelings and possible apprehensions of professionals to work on a daily basis with a child with FA.</p></div><div><h3>Methods</h3><p>Survey conducted in 2023 with 50 staff working in different childcare facilities.</p></div><div><h3>Results</h3><p>Seventy-four per cent had initial training on FA, 64% had no training on FA since taking a position in nursery and 66% never handled an adrenaline auto-injector (AAI). Twenty-one per cent of the structures have an internal medicine cabinet to support an inaugural reaction of FA and 14% are equipped with AAI (internal stock not taking into account the AAI of possible IRP). Sixty-eight per cent know that they are allowed to apply the IRP themselves in emergency situations in the nursery, in connection with the ministerial circular of 2021. Sixty-six per cent are comfortable in the daily reception of the child with FA, 38% are comfortable with the handling of the AAI.</p></div><div><h3>Conclusion</h3><p>Given the increasing frequency of FA in small children, it is necessary for early childhood professionals to be better trained and informed during their studies and in the nursery, especially on the administration of AAI. It is desirable that an in-house pharmacy be equipped with AAI for the management of inaugural FA.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104138"},"PeriodicalIF":0.3,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L’école de la dermatite atopique en dermatologie à Dakar : étude d’impact sur les connaissances à propos de 22 participants 达喀尔皮肤科特应性皮炎学校：对 22 名学员知识的影响研究

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-08-23 DOI: 10.1016/j.reval.2024.104141

S. Diadie, M. Tajaoui, P.M. Mbengue, B.A. Diatta, M. Ndiaye, S.O. Niang

{"title":"L’école de la dermatite atopique en dermatologie à Dakar : étude d’impact sur les connaissances à propos de 22 participants","authors":"S. Diadie, M. Tajaoui, P.M. Mbengue, B.A. Diatta, M. Ndiaye, S.O. Niang","doi":"10.1016/j.reval.2024.104141","DOIUrl":"10.1016/j.reval.2024.104141","url":null,"abstract":"<div><h3>Introduction</h3><p>The aims of this study was to evaluate the impact of therapeutic education on the knowledge and skills of patients with atopic dermatitis at the Aristide Le Dantec University Hospital.</p></div><div><h3>Patients and method</h3><p>This prospective educational intervention study included 22 participants with AD. Knowledge was assessed before and after the therapeutic education sessions. The educational tools of the Pierre-Fabre Eczema Foundation translated into power points served as educational support to which creations of educational tools and iconographies on black skin were added. The comparison of means was made using the Student test.</p></div><div><h3>Results</h3><p>The educational diagnosis highlighted a lack of knowledge of: the disease, its aggravating factors, its treatments as well as frequent corticophobia. The therapeutic education allowed the acquisition of theoretical knowledge and practical skills in addition to empowering the participants. In addition, it reduced corticophobia although fear of topical corticosteroids persisted.</p></div><div><h3>Conclusion</h3><p>Patient therapeutic education through educational tools contextualized for our patients made it possible to improve knowledge and skills during atopic dermatitis.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104141"},"PeriodicalIF":0.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological, clinical, and etiological features of pediatric prurigo in Morocco: About 168 cases 摩洛哥小儿瘙痒症的流行病学、临床和病因特征：约 168 例

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-08-23 DOI: 10.1016/j.reval.2024.104139

F. Elfatoiki, H. Tahiri, A. El Jei, H. Skali, F. Hali, S. Chiheb

{"title":"Epidemiological, clinical, and etiological features of pediatric prurigo in Morocco: About 168 cases","authors":"F. Elfatoiki, H. Tahiri, A. El Jei, H. Skali, F. Hali, S. Chiheb","doi":"10.1016/j.reval.2024.104139","DOIUrl":"10.1016/j.reval.2024.104139","url":null,"abstract":"<div><p>Prurigo is a frequent disease in childhood. The aim of our work is to document the epidemiological, clinical, and etiological features of prurigo in children. It is a retrospective study carried out from January 2016 to December 2023 in the pediatric dermatology consultation of Ibn Rochd University Hospital in Morocco. All children from 0–14 years diagnosed clinically with prurigo were included. The prevalence of prurigo was 18% in the pediatric population. The mean age at the onset of the disease was 2.43 years. Pruritus was reported in all patients. Three subgroups were identified: estival prurigo: 43.45% of cases, per-annual: 25.60% of cases, and seasonal non-estival prurigo: 30.95% of cases. Thirty-five percent of patients reported an exacerbation of lesions by the consumption of histamine-releasing foods or those containing additives and colorants. Estival prurigo is the most common form of prurigo in children, lesions predominate in exposed areas and are induced by mosquito bites. Our study highlights a possible association with histamine-liberating foods.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 6","pages":"Article 104139"},"PeriodicalIF":0.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phloroglucinol-induced acute generalized exanthematous pustulosis: Unveils an uncommon culprit 氯霉素诱发的急性全身泛发性脓疱病：揭示一种不常见的罪魁祸首

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-07-24 DOI: 10.1016/j.reval.2024.104140

G. Ferjani , A. Chamli , K. Ferchichi , M. Cherif , R. Frioui , H. Hammami , S. Fenniche , A. Zaouak

{"title":"Phloroglucinol-induced acute generalized exanthematous pustulosis: Unveils an uncommon culprit","authors":"G. Ferjani , A. Chamli , K. Ferchichi , M. Cherif , R. Frioui , H. Hammami , S. Fenniche , A. Zaouak","doi":"10.1016/j.reval.2024.104140","DOIUrl":"10.1016/j.reval.2024.104140","url":null,"abstract":"<div><p>Acute generalized exanthematous pustulosis (AGEP) is an uncommon and potentially life-threatening skin reaction primarily triggered by medications, notably antibiotics. Herein, we present a rare case of AGEP induced by phloroglucinol, a drug not commonly associated with AGEP, with a short literature review. A previously healthy 31-year-old woman exhibited fever and a pruritic widespread rash characterized by diffuse erythema interspersed with pustules, manifesting five days following oral phloroglucinol intake. Neutrophilic leukocytosis was evident upon blood analysis. Microbiological assessment confirmed the pustules to be sterile. Histopathological examination unveiled multifocal intra-epidermal pustules, exoserosis, and a polymorphic dermal infiltrate primarily comprising neutrophils and eosinophils. Diagnosis of phloroglucinol-induced AGEP was established, with an intrinsic imputability score of I4 (S3 C3) as per the updated criteria proposed by Begaud et al. Subsequent cessation of the offending drug led to marked improvement in the patient's condition. This case underscores the importance of considering less recognized culprits, such as phloroglucinol, in the etiology of AGEP, thereby broadening the spectrum of drugs implicated in this severe dermatological reaction. Early recognition and prompt withdrawal of the offending agent remain pivotal in mitigating AGEP-associated morbidity and mortality.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 5","pages":"Article 104140"},"PeriodicalIF":0.3,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propriétés allergiques et activatrices de MRGPRX2 des médicaments : vers un algorithme mécanistique résolutif 药物的过敏性和 MRGPRX2 激活特性：迈向解析性机理算法

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-07-09 DOI: 10.1016/j.reval.2024.104121

D.G. Ebo , J. Elst , M.M. van der Poorten , A. Toscano , A.L. Van Gasse , C. Mertens , M. Van Houdt , M. Beyens , V. Sabato

{"title":"Propriétés allergiques et activatrices de MRGPRX2 des médicaments : vers un algorithme mécanistique résolutif","authors":"D.G. Ebo , J. Elst , M.M. van der Poorten , A. Toscano , A.L. Van Gasse , C. Mertens , M. Van Houdt , M. Beyens , V. Sabato","doi":"10.1016/j.reval.2024.104121","DOIUrl":"https://doi.org/10.1016/j.reval.2024.104121","url":null,"abstract":"<div><p>Depuis la description séminale impliquant l’occupation du récepteur X2 couplé à la protéine G liée à Mas (MRGPRX2) dans la dégranulation des mastocytes (MCs) par les médicaments, de nombreuses études ont été entreprises sur ce nouvel endotype potentiel de réactions d’hypersensibilité immédiate aux médicaments (RHMIs). Cependant, les preuves actuelles de ce mécanisme proviennent principalement de modèles animaux (mutants) ou d’études in vitro. Des preuves cliniques irréfutables chez l’homme font défaut. De plus, la traduction de ces résultats précliniques en pertinence clinique chez l’homme est difficile et doit être interprétée de manière critique. En partant de nos priorités cliniques et de notre expérience des analyses fonctionnelles des basophiles, MCs et lymphocytes T, l’objectif de cette revue est d’identifier certaines de ces difficultés, de souligner les obstacles qui pourraient entraver la transposition des observations précliniques en clinique et de mettre en évidence les différences entre les réactions médiées par les sIgE et par le MRGPRX2. Finalement, nous proposons un algorithme mécanistique théorique qui pourrait faciliter la discrimination entre la dégranulation des MCs due à l’activation de MRGPRX2 et la réticulation des anticorps IgE liés à la membrane et réactifs aux médicaments.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 5","pages":"Article 104121"},"PeriodicalIF":0.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndrome de Babouin : réaction inhabituelle à l’amoxicilline-acide clavulanique 狒狒综合征：对阿莫西林-克拉维酸的异常反应

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-07-08 DOI: 10.1016/j.reval.2024.104137

O. Hormi , I. Ouadi , N. Tahri , S. Dikhaye , N. Zizi

引用次数: 0

Profil de sensibilisation aux pneumallergènes des patients asthmatiques au Centre hospitalier universitaire de Brazzaville 布拉柴维尔大学医院中心的哮喘病人对肺过敏原的过敏特征

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-07-08 DOI: 10.1016/j.reval.2024.104120

E.L.P. Bemba , R.G. Bopaka , R.A. Malonga Afouna , H. Mbéré Ossema , F.H. Okemba Okombi , K.B. Ossale Abacka

{"title":"Profil de sensibilisation aux pneumallergènes des patients asthmatiques au Centre hospitalier universitaire de Brazzaville","authors":"E.L.P. Bemba , R.G. Bopaka , R.A. Malonga Afouna , H. Mbéré Ossema , F.H. Okemba Okombi , K.B. Ossale Abacka","doi":"10.1016/j.reval.2024.104120","DOIUrl":"https://doi.org/10.1016/j.reval.2024.104120","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine the frequency of allergic asthma; to describe the socio-demographic, clinical and paraclinical characteristics; to define the type of sensitization; to identify factors associated with the type of sensitization.</p></div><div><h3>Methods</h3><p>This was a cross-sectional study from August to December 2020 of asthmatic patients consecutively recruited in the pneumology and pediatrics departments of the Brazzaville University Hospital Center and who had completed a prick test. The standardized allergenic extracts used were: positive and negative control, mites (<em>Dermatophagoides pteronyssinus</em> [DP], <em>Dermatophagoides farinae</em> [DF] and <em>Blomia tropicalis</em>), cockroaches, molds (<em>Alternaria alternata</em>, <em>Cladosporium herbarum</em>, <em>Penicillium notatum</em>, <em>Aspergillus fumigatus</em>), pollen (5 grasses), hair (cat and dog) and latex.</p></div><div><h3>Results</h3><p>Of fifty-nine patients tested, 52 (88.1%) had at least one positive skin reaction. The average age was 29.5 years, and there was a predominance of women (63.5%). Of these patients, 82.7% were polysensitized and the average number of sensitizations was 3±2. Sensitization to dust mites was the most frequent (80.7%) followed by cockroaches (46.2%). We noted a significant association between mite sensitization and young age (<em>P</em>  =0.0002). A significant association was found in our study between cockroach sensitization and asthma severity (<em>P</em>  <!-->0.02).</p></div><div><h3>Conclusion</h3><p>Asthmatics followed in Brazzaville have a polysensitization dominated by dust mites.</p></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"64 5","pages":"Article 104120"},"PeriodicalIF":0.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red ear syndrome in the differential diagnosis of allergic contact dermatitis: A pediatric case report 过敏性接触性皮炎鉴别诊断中的红耳综合征：儿科病例报告

IF 0.3 4区医学

Revue Francaise d Allergologie Pub Date : 2024-07-08 DOI: 10.1016/j.reval.2024.104122

M. Özer, S. Doğan, S. Tekeli, C. Aytekin

引用次数: 0