Revue Francaise d Allergologie最新文献

{"title":"Drug reaction with eosinophilia and systemic symptoms syndrome to non-steroidal anti-inflammatory drugs: A report of case series and literature review","authors":"M. Daldoul ,&nbsp;O. Charfi ,&nbsp;F. Zgolli ,&nbsp;K. Ferchichi ,&nbsp;G. Lakhoua ,&nbsp;S. Kastalli ,&nbsp;R. Daghfous ,&nbsp;A. Zaiem ,&nbsp;I. Aouinti ,&nbsp;S. El Aidli","doi":"10.1016/j.reval.2024.104221","DOIUrl":"10.1016/j.reval.2024.104221","url":null,"abstract":"<div><h3>Introduction</h3><div>DRESS syndrome is a rare, severe cutaneous adverse reaction that has been exceptionally described with NSAIDs. The objective of our study was to investigate the clinical, paraclinical, and epidemiological characteristics of DRESS syndrome associated with NSAIDs and to identify the implicated molecules.</div></div><div><h3>Patients and methods</h3><div>A retrospective descriptive study that included all cases of DRESS syndrome occurring with NSAIDs and reported over a 10-year period. Records were analyzed according to the RegiSCAR criteria for the diagnosis of DRESS and the French imputability method.</div></div><div><h3>Results</h3><div>We included 7 cases, with a female-to-male ratio of 1.33. The age of patients ranged from 18 to 75 years, with a mean of 55 years. The time to onset varied from 4 to 30 days, with a mean of 12 days. A fever equal to or greater than 38.5<!--> <!-->°C was observed in 5 patients. All patients had skin involvement, mainly in the form of a maculopapular rash in 6 cases and erythroderma with glossitis in one case. Hypereosinophilia was found in 4 out of 7 patients. Hepatic involvement was observed in 4 patients, associated with renal involvement in 2 cases. One patient had isolated renal involvement. The NSAIDs implicated in DRESS syndrome in our patients were diclofenac, piroxicam, ketoprofen, and celecoxib.</div></div><div><h3>Conclusion</h3><div>Our study highlights the rarity and potential severity of DRESS syndrome associated with NSAIDs, due to systemic involvement. Clinicians should be vigilant about the possibility of DRESS syndrome with NSAID use, in order to promptly discontinue the implicated drug and ensure rapid management.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 4","pages":"Article 104221"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yellow mealworm (Tenebrio molitor): A rare cause of chronic urticaria","authors":"D. Tekcan,&nbsp;I. Kulhas Celik,&nbsp;H. Artac","doi":"10.1016/j.reval.2025.104255","DOIUrl":"10.1016/j.reval.2025.104255","url":null,"abstract":"<div><div>This report presents a unique case of chronic urticaria (CU) caused by a food allergy to mealworm. A 10-year-old boy experienced daily itchy urticarial rashes for three months, accompanied by swelling, especially in the morning. Despite high-dose second-generation antihistamines, montelukast, a hypoallergenic diet, and intermittent steroids, symptoms persisted. Routine investigations, including hemogram, thyroid function tests, and autoantibodies, were normal. Total IgE level was elevated (715<!--> <!-->kU/L), but skin prick tests showed no sensitivities. Component-resolved diagnosis revealed a reaction to yellow mealworm (<em>Tenebrio molitor</em>, 0.53<!--> <!-->kUA/L). Investigation uncovered daily bread consumption prepared from flour stored in non-heat-resistant sacks, where mealworms proliferated. Symptom resolution followed dietary elimination of contaminated flour, enabling treatment tapering. <em>Tenebrio molitor</em> thrives in high-temperature storage and is increasingly used as a protein source. Cross-reactivity with shrimp allergens is documented. This case highlights the role of environmental factors in CU and the utility of component-resolved diagnostics. Identifying yellow mealworm as a rare CU cause emphasizes the importance of comprehensive evaluation in persistent cases.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104255"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prise en charge des allergies professionnelles dans les services de prévention en santé au travail dans le département des Bouches-du-Rhône : enquête de satisfaction auprès des médecins du travail et proposition d’un projet innovant","authors":"M. MENDIL","doi":"10.1016/j.reval.2025.104539","DOIUrl":"10.1016/j.reval.2025.104539","url":null,"abstract":"<div><h3>Aim of the study</h3><div>To study the preventive management of employees exposed to the risk of occupational allergy and occupational physicians’ satisfaction in the Bouches-du-Rhône department. The secondary objective was to study occupational physicians’ interest in an innovative project to set up an occupational allergy unit within the occupational health prevention department.</div></div><div><h3>Patients and methods</h3><div>Descriptive, cross-sectional epidemiological study including occupational physicians working in an occupational health prevention service in the Bouches-du-Rhône who responded to the questionnaire.</div></div><div><h3>Results</h3><div>According to the 50 occupational physicians who took part in the study, the preventive management of occupational allergies in their department was judged to be in need of improvement (88%, i.e. 44 of occupational physicians). Primary prevention (<em>n</em> <!-->=<!--> <!-->37 or 74%) is most concerned along with secondary prevention (<em>n</em> <!-->=<!--> <!-->33 or 66%). Tertiary prevention was considered to be improvable to a lesser extent (<em>n</em> <!-->=<!--> <!-->24 or 48%). The majority of occupational physicians (<em>n</em> <!-->=<!--> <!-->32 or 64%) believe that the presence of this unit would be beneficial in improving the management of occupational allergies within their occupational health department.</div></div><div><h3>Conclusion</h3><div>A majority of occupational physicians consider that practice can be improved, mainly in terms of primary and secondary prevention. The high level of support for the innovative project among occupational health physicians justifies its creation within the occupational health prevention department. In the future, the project will be evaluated to prove its usefulness and relevance.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104539"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of biological agent use on symptoms in patients diagnosed with NSAID-Exacerbated Respiratory Disease (NERD)","authors":"H. Çelik Tuğlu,&nbsp;K. Aksu,&nbsp;O. Telli,&nbsp;F. Dindar Çelik,&nbsp;M. Yağdıran,&nbsp;Ö. Akkale,&nbsp;G. Köycü Buhari,&nbsp;S.N. Bahçecioğlu,&nbsp;G.T. Vural Solak","doi":"10.1016/j.reval.2024.104219","DOIUrl":"10.1016/j.reval.2024.104219","url":null,"abstract":"<div><h3>Introduction</h3><div>In recent years, biological approaches targeting Type 2 cytokines have emerged as potential treatment options in NSAID-Exacerbated Respiratory Disease (NERD) patients. In this study, we aimed to evaluate the clinical efficacy of omalizumab and mepolizumab in NERD patients with severe asthma via nasal and respiratory symptoms, pulmonary functions and exacerbation status.</div></div><div><h3>Methods</h3><div>The study was conducted retrospectively in adults with NERD who were initiated on omalizumab and mepolizumab and had been treated with a biologic agent for at least 1 year. Data on lung function test results, eosinophil counts, asthma exacerbation rates, asthma control levels, and Sino-Nasal Outcome Test-22 scores before starting the biological agent were compared with data obtained 1 year after starting the biological treatment.</div></div><div><h3>Results</h3><div>The study included data from 18 NERD patients, 10 of whom received omalizumab and 8 of whom received mepolizumab. In the NERD group receiving omalizumab, statistically significant changes were observed in terms of clinical improvement in FEV1 values, mean eosinophil counts, annual exacerbation rates, asthma control and SNOT-22 scores after biologic treatment. In patients receiving mepolizumab, significant decreases were found in mean eosinophil counts, annual exacerbation rates and SNOT-22 scores after biologic treatment compared to pre-treatment. Daily oral corticosteroid requirements were significantly reduced in patients receiving both omalizumab and mepolizumab.</div></div><div><h3>Conclusion</h3><div>In conclusion, the present study results reveal that both omalizumab and mepolizumab treatments are effective in controlling nasal symptoms, reducing the number of asthma exacerbations, and reducing the need for low-dose maintenance steroids in severe asthmatics with NERD.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 4","pages":"Article 104219"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food allergy in adults. Is there a difference between HIV and non-HIV patients?","authors":"R. Cohen ,&nbsp;S. Nemet ,&nbsp;K. Mahlab-Guri ,&nbsp;L. Kadar ,&nbsp;I. Asher ,&nbsp;S. Rosenberg-Bezalel ,&nbsp;D. Elbirt","doi":"10.1016/j.reval.2025.104252","DOIUrl":"10.1016/j.reval.2025.104252","url":null,"abstract":"<div><h3>Background</h3><div>Human Immunodeficiency Virus infection is known to cause significant immunological changes, including a shift towards a Th2-dominant immune response, which is typically associated with allergic conditions. However, the relationship between HIV infection and the incidence of food allergies remains unclear.</div></div><div><h3>Objective</h3><div>This study aims to investigate the incidence of food allergies in HIV-infected patients compared to a non-HIV population.</div></div><div><h3>Methods</h3><div>This retrospective cohort study utilized observational data including individuals diagnosed with HIV between 2004 and 2023. A control group matched for age and sex (1:60) was created from non-HIV individuals. Data on allergic conditions were extracted using ICD9 codes, and statistical analyses were conducted using Cox proportional hazards models to assess the effect of HIV on food allergy incidence over a 10-year follow-up period.</div></div><div><h3>Results</h3><div>The study included 1616 HIV-positive patients and 95,773 controls. While higher rates of asthma and atopic dermatitis were observed in the HIV group, no cases of food allergy were detected among HIV patients, compared to 185 cases in the non-HIV cohort. The adjusted hazard ratios indicated that factors such as asthma, atopic dermatitis, vitamin D insufficiency, and kidney transplantation were associated with increased food allergy risk in the non-HIV population.</div></div><div><h3>Conclusion</h3><div>Despite the Th2-dominant immune environment associated with HIV infection, no increased risk of food allergy was observed in HIV-positive individuals over a 10-year period. This suggests that the immunological alterations caused by HIV may not predispose patients to food allergies as they do to other allergic conditions.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104252"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Évolution fatale liée à l’abus de dermocorticoïdes chez un adulte","authors":"S. Ait Oussous ,&nbsp;I. Lakhal ,&nbsp;M. Hamaichat ,&nbsp;I. Damoune ,&nbsp;F. Ajdi ,&nbsp;R. Chakiri","doi":"10.1016/j.reval.2024.104220","DOIUrl":"10.1016/j.reval.2024.104220","url":null,"abstract":"<div><h3>Introduction</h3><div>Topical corticosteroids are widely used in the management of chronic inflammatory dermatoses with impaired skin barrier, such as atopic dermatitis and psoriasis. However, their long-term use can lead to systemic effects due to percutaneous absorption. We report a case illustrating the severity of complications associated with excessive use of these medications.</div></div><div><h3>Observation</h3><div>A 32-year-old woman had been under follow-up for a dermatologic condition with a relapsing-remitting course, evolving since the age of 3. She was initially treated with a high-potency topical corticosteroid, which led to good improvement. However, she continued self-administering topical corticosteroids for 22<!--> <!-->years. She presented with erythroderma characterized by desquamation, edema, and erosions in some areas. The clinical presentation, along with excessive use of betamethasone, suggested iatrogenic Cushing's syndrome. Laboratory tests revealed corticotropic adrenal insufficiency. A skin biopsy confirmed the diagnosis of atopic dermatitis. Management included treatment of fungal, infectious, and metabolic complications. Hydrocortisone was initiated, and after education, topical corticosteroids were replaced with topical tacrolimus. The patient was lost to follow-up and succumbed to adrenal insufficiency one month later.</div></div><div><h3>Conclusion</h3><div>This case highlights the severity of iatrogenic complications secondary to misuse of topical corticosteroids and underscores the need for proper therapeutic education and adequate follow-up.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 4","pages":"Article 104220"},"PeriodicalIF":0.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La faute au thon ou au chef ? Enquêter sur une cause inhabituelle d’anaphylaxie","authors":"J. Nogueira Oliveira ,&nbsp;J. Carvalho Queirós ,&nbsp;R. Calejo ,&nbsp;R. Teixeira ,&nbsp;R. Gomes ,&nbsp;L. Marques ,&nbsp;D. Pinto ,&nbsp;A.R. Araújo ,&nbsp;F. Teixeira","doi":"10.1016/j.reval.2024.104224","DOIUrl":"10.1016/j.reval.2024.104224","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104224"},"PeriodicalIF":0.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DRESS : panorama sur ses aspects phénotypiques et étiologiques à propos de 32 cas","authors":"S. Diadié,&nbsp;D.E.T. Ngbwa,&nbsp;M. Sarr,&nbsp;P.M. Mbengue,&nbsp;M. Diallo,&nbsp;S.O. Niang","doi":"10.1016/j.reval.2024.104225","DOIUrl":"10.1016/j.reval.2024.104225","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 4","pages":"Article 104225"},"PeriodicalIF":0.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum à l’article « Enfant présentant une allergie alimentaire en crèche : quelle est la place du Projet d’Accueil Individualisé ? Quels ressentis pour le personnel ? » [Rev. Fr. Allergol. 64 (6) (2024) 104138]","authors":"A. Thong Buisson ,&nbsp;M.-C. Leoni","doi":"10.1016/j.reval.2025.104250","DOIUrl":"10.1016/j.reval.2025.104250","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104250"},"PeriodicalIF":0.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy lifestyle in 0–6-year-old children's parents with food and non-food allergy","authors":"C. Cakici ,&nbsp;S. Şeker ,&nbsp;A.D. Karaman","doi":"10.1016/j.reval.2024.104205","DOIUrl":"10.1016/j.reval.2024.104205","url":null,"abstract":"<div><h3>Background</h3><div>Health lifestyle behaviors of parents with food and non-food allergic children are not well understood.</div></div><div><h3>Objective</h3><div>This study aimed to examine the difference between healthy lifestyle behaviors of parents of 0–6-year-old children with food allergies and non-food allergies.</div></div><div><h3>Methods</h3><div>This analytical cross-sectional study was conducted with the parents of 153 allergic children admitted to Aydin Obstetrics, Gynecology and Child Diseases Hospital between October 2022 and March 2023. “Personal Information Form” and “Health Promoting Lifestyle Profile II” were used to collect data and analyzed using Mann-Whitney-U, chi-square test, Student-<em>t</em> test.</div></div><div><h3>Results</h3><div>The mean total score of the Health-Promoting Lifestyle Profile II was 135.4<!--> <!-->±<!--> <!-->19.5 for parents of food allergic children and 139.1<!--> <!-->±<!--> <!-->24.1 for parents of non-food allergic children. There was no significant difference between the total scores of the Health-Promoting Lifestyle Profile II between the parents of allergic children (<em>t</em> <!-->=<!--> <!-->−1.048, <em>P</em> <!-->&gt;<!--> <!-->0.05). While there was no significant difference in terms of the other subscales of the questionnaire, the physical activity subscale mean score of parents of children with non-food allergies was higher than those with food allergies (<em>t</em> <!-->=<!--> <!-->−1.986, <em>P</em> <!-->=<!--> <!-->0.049). Child's age, parental education level, and family history were found to be significant factors in the development of food allergies (<em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>While there was no difference in the healthy lifestyle behaviors of parents with food allergic and non-food allergic children, it was concluded that parents with non-food allergic children had better lifestyles only for the “Physical Activity” subscale. It may be recommended that healthcare professionals should give importance to this issue to improve the healthy lifestyle of individuals in vulnerable groups.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 3","pages":"Article 104205"},"PeriodicalIF":0.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}