Revue Francaise d Allergologie最新文献

{"title":"Analyses assistées par cytométrie en flux des basophiles, mastocytes et lymphocytes T dans le diagnostic de l’hypersensibilité immédiate aux médicaments (RHIMs) : une revue","authors":"D.G. Ebo ,&nbsp;C. Mertens ,&nbsp;M. Van Houdt ,&nbsp;A. Toscano ,&nbsp;M. Beyens ,&nbsp;M.M. Hagendorens ,&nbsp;D. Yerly ,&nbsp;V. Sabato ,&nbsp;O. Hausmann ,&nbsp;J. Elst","doi":"10.1016/j.reval.2025.104634","DOIUrl":"10.1016/j.reval.2025.104634","url":null,"abstract":"<div><div>Immediate drug hypersensitivity reactions (IDHRs) pose significant diagnostic challenges, often requiring potentially hazardous drug challenge testing (DCT). Recent studies have indicated that flow cytometry-based cellular tests, including the basophil activation test (BAT), the mast cell activation test (MAT), and the T cell activation test (TAT), offer a promising alternative to reduce DCT reliance. While these tests are still in development, they demonstrate potential to compete with skin tests by providing superior diagnostic performance and improved patient safety by reducing the need for DCT. Moreover, it is encouraging that these flow cytometry-based tests are also suitable for challenging populations, such as children. Despite requiring specialised infrastructure, these tests have the potential to be cost-effective when performed in reference centres and may offer unique mechanistic insights into immediate drug hypersensitivity reactions. However, further research is required to validate their reliability, address pharmaceutical-specific testing considerations, and potentially integrate them into clinical guidelines.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104634"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Réintroduction médicamenteuse en allergologie : niveau de confiance et intention de reprise","authors":"C. André,&nbsp;C. Bara,&nbsp;H. Maillard","doi":"10.1016/j.reval.2025.104618","DOIUrl":"10.1016/j.reval.2025.104618","url":null,"abstract":"<div><h3>Introduction</h3><div>Drug provocation tests are gold standard to confirm or exclude drug allergy. Few studies have specifically investigated patients’ adherence after a negative test and the determinants of their level of trust in the procedure. We aimed to assess both the trust level and the intention to resume the reintroduced drugs in adult patients who had completed a full allergology workup, including a negative drug provocation test.</div></div><div><h3>Methods</h3><div>This retrospective, cross-sectional, observational, descriptive, and analytical study was conducted in the Allergy unit of Le Mans hospital between April and July 2025. It included 305 drug provocation tests with negative outcomes performed in 230 patients reintroduced between 2017 and 2021.</div></div><div><h3>Results</h3><div>A total of 64.3% of surveyed patients reported a satisfactory trust level (at least<!--> <!-->7/10) in the drug provocation tests for a future resumption of the drug. Among our patients, 35.4 % had already resumed the treatment after reintroduction. The mean trust score was 7.02/10, rising to 8.90/10 among “confident” patients who were willing to resume the drug at home. The reintroduction of a corticosteroid or the presence of polyallergy in the patient's record appeared to be the two main factors of reluctance to resume treatment. Forty-four percent of patients did not recall having a written record of the drug provocation test outcome.</div></div><div><h3>Conclusion</h3><div>We found post-drug provocation test adherence to be consistent with the literature. A specific focus on patients at high risk of non-adherence could improve their level of treatment resumption. Providing a document confirming the absence of allergy, or adding a “drug tested and reintroduced” note to the patient's digital health record, appear to be promising approaches to counter forgetting and/or misreporting to healthcare professionals managing the patient in the future.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104618"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of neutrophil-lymphocyte, platelet-lymphocyte ratio in urticaria","authors":"Öner Özdemir","doi":"10.1016/j.reval.2025.104620","DOIUrl":"10.1016/j.reval.2025.104620","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104620"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pomegranate-induced refractory anaphylaxis in a toddler","authors":"E. Bahadir,&nbsp;B. Can Duran,&nbsp;S. Demirsöz,&nbsp;C. Aytekin,&nbsp;S. Özmen","doi":"10.1016/j.reval.2025.104640","DOIUrl":"10.1016/j.reval.2025.104640","url":null,"abstract":"<div><div>Pomegranate (Punica granatum) is a fruit rich in antioxidants and commonly consumed worldwide. However, although generally well tolerated, it has rarely been implicated in severe allergic reactions, including anaphylaxis. We report the case of a 3.5-year-old boy with a five-month history of recurrent periorbital angioedema. Careful history revealed pomegranate ingestion preceding one of these episodes. During an oral food challenge with pomegranate, he developed refractory anaphylaxis requiring repeated intramuscular administrations of epinephrine and a continuous epinephrine infusion. This case highlights that, despite being an uncommon food allergen, pomegranate can provoke life- threatening systemic reactions in children. Clinicians should be aware of this potential and consider it in the differential diagnosis of unexplained recurrent angioedema or anaphylaxis.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104640"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Dr. Özdemir's Letter","authors":"S. Çevik ,&nbsp;U. Altaş ,&nbsp;H. Alkaya ,&nbsp;A. Sarısaltık ,&nbsp;M.Y. Özkars","doi":"10.1016/j.reval.2025.104619","DOIUrl":"10.1016/j.reval.2025.104619","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104619"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Un cas rare de DRESS syndrome suite à la prise d’acénocoumarol","authors":"A. Lahrougui,&nbsp;M. Aboudourib,&nbsp;L. Bendaoud,&nbsp;S. Amal,&nbsp;O. Hocar","doi":"10.1016/j.reval.2025.104621","DOIUrl":"10.1016/j.reval.2025.104621","url":null,"abstract":"<div><div>We describe a rare case of DRESS syndrome in a 55-year-old patient who was hospitalized for a cardiac arrhythmia requiring the introduction of acenocoumarol. Three weeks after taking acenocoumarol, the patient developed a generalized morbiliform maculopapular exanthema, surmounted by petechial purpuric lesions on the back, trunk and both lower limbs, associated with facial edema and a fever of 38.1°, with no clinically palpable adenopathies. Biological tests revealed hypeosinophilia and major hepatic cytolysis. According to the REGISCAR (Registry of Severe Cutaneous Adverse Reaction) score at 5 based on the clinical and biological aspects concomitant with drug intake, we retained the diagnosis of DRESS syndrome induced by acenocoumarol intake. The patient was treated with oral and topical cotricotherapy with good clinical and biological improvement.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104621"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensibilisation aux allergènes polliniques au Maroc : revue des données cliniques publiées de 2000 à 2025","authors":"O. Bouaissa","doi":"10.1016/j.reval.2025.104639","DOIUrl":"10.1016/j.reval.2025.104639","url":null,"abstract":"<div><div>Pollens are among the main seasonal allergens that trigger allergic respiratory diseases, which represent a real public health challenge worldwide. In Morocco, several studies have been conducted to identify the most involved pollens and the associated respiratory diseases. The review of clinical studies published from 2000 to 2025 confirms the dominance of olive tree and grasses at the top of pollen allergens in Morocco. Other pollens, such as cypress, <em>Parietaria</em>, <em>Artemisia</em>, mimosa, and date palm, have shown significant allergenic power but only locally. This distribution is mainly influenced by floristic richness, climate, and air pollution. Allergic rhinitis is the most common response to all pollens, often accompanied by asthma, followed by conjunctivitis and, in some cases, urticaria. Another range of pollens tested only in Casablanca or revealed through surveys deserves further study. Moreover, other chronic diseases reported in these same surveys require clinical investigations. This will help optimize the management and care of allergic respiratory diseases, particularly those triggered by pollens.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"66 1","pages":"Article 104639"},"PeriodicalIF":0.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectorragies révélatrices d’une allergie alimentaire après une transplantation hépatique : à propos d’un cas","authors":"M. Sabib,&nbsp;T. Meskini,&nbsp;S. Ettair","doi":"10.1016/j.reval.2025.104600","DOIUrl":"10.1016/j.reval.2025.104600","url":null,"abstract":"<div><div>Les allergies alimentaires et hypersensibilités médicamenteuses sont des complications de plus en plus reconnues après transplantation hépatique pédiatrique, avec une prévalence pouvant atteindre 54,3 %. Les allergies alimentaires IgE-médiées se manifestent fréquemment par des signes cutanés et des symptômes gastro-intestinaux tels que douleurs abdominales et diarrhées, tandis que les rectorragies comme présentation initiale restent rares. Nous rapportons le cas original d’une fillette de 12 mois ayant bénéficié d’une transplantation hépatique à l’âge de 9 mois. Elle présentait une atrésie des voies biliaires, initialement traitée par dérivation bilio-digestive sans succès, ayant évolué vers une cirrhose hépatique compliquée d’insuffisance hépatocellulaire, motivant la greffe hépatique et la mise en place d’une immunosuppression par tacrolimus. Elle a présenté deux épisodes de rectorragies de grande abondance. Une évaluation allergologique a confirmé une allergie IgE-médiée à l’œuf et une proctocolite hémorragique associée à une hypersensibilité aux protéines du lait de vache. De plus, une hypersensibilité à l’aspirine a été confirmée par un test de provocation orale. La prise en charge a inclus un régime d’éviction de l’œuf de poule et du lait de vache ainsi qu’un protocole de désensibilisation à l’aspirine, entraînant une amélioration clinique juste après éviction des allergènes. La survenue de ces rectorragies pourrait s’expliquer par des perturbations immunitaires induites par la transplantation hépatique, notamment sous tacrolimus. Cet immunosuppresseur favorise une réponse Th2 avec production accrue d’IgE. Associé aux antibiotiques, il altère le microbiote intestinal et augmente la perméabilité digestive, facilitant la sensibilisation aux allergènes. Ce cas souligne l’importance d’un dépistage allergologique pré-greffe et d’un suivi étroit après transplantation. Une vigilance particulière doit être accordée aux manifestations cliniques atypiques, telles que les rectorragies, afin de ne pas méconnaître une cause allergique et d’optimiser la prise en charge.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104600"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome d’entérocolite médicamenteuse induite par la ropivacaïne injectée par voie péri-nerveuse : premier cas rapporté","authors":"J. Herry ,&nbsp;C. Chassery ,&nbsp;M. Virtos ,&nbsp;D. Sabouraud ,&nbsp;P. Beaumont ,&nbsp;C. Ponvert","doi":"10.1016/j.reval.2025.104586","DOIUrl":"10.1016/j.reval.2025.104586","url":null,"abstract":"<div><div>Rare cases of drug-induced enterocolitis syndrome have been reported with drugs administered by the oral (amoxicillin, pantoprazole) and intrarectal (paracetamol) routes. No cases have been described by injectable route. Diagnostic criteria, close to those of food protein-induced enterocolitis syndrome, have been proposed in 2019. We report the case of a 72-year-old patient scheduled for a total knee arthroplasty and recused on two occasions after rapid occurrence of drug-induced enterocolitis after peri-nervous injection of ropivacaine during a nerve block carried out before the surgery. Skin tests performed after the first reaction, according to EEACI/ENDA (European Academy of Allergy and Clinical Immunology) recommendations, were negative. The drug provocation test with ropivacaine was also negative. However, the symptoms recurred at the second anesthesia. A few cases of IgE-mediated hypersensitivity to local anesthetics have been reported, but, to our knowledge, this is the first case of drug-induced enterocolitis syndrome induced by an injectable drug, ropivacaine, recurring although skin tests and provocation test resulted negative.</div></div>","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104586"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144809730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measles–mumps–rubella vaccine in children with food allergies","authors":"H. Yağmur ,&nbsp;Ö. Atay ,&nbsp;S. Asilsoy ,&nbsp;N. Uzuner","doi":"10.1016/j.reval.2025.104617","DOIUrl":"10.1016/j.reval.2025.104617","url":null,"abstract":"","PeriodicalId":49130,"journal":{"name":"Revue Francaise d Allergologie","volume":"65 6","pages":"Article 104617"},"PeriodicalIF":0.3,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}