Contact Lens & Anterior Eye最新文献

{"title":"The association between corneal immune cell dynamics and comfort in silicone hydrogel contact lens wearers.","authors":"Laura Valencia-Nieto, Katie Edwards, Azadeh Tavakoli, María J González-García, Alberto López-Miguel, Samantha Dando, Alex Hui, Maria Markoulli, Eric B Papas, Luisa H Colorado","doi":"10.1016/j.clae.2025.102424","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102424","url":null,"abstract":"<p><strong>Purpose: </strong>To study the association between corneal immune cell dynamics and contact lens (CL) comfort, as well as tear film inflammatory mediators in established CL wearers.</p><p><strong>Methods: </strong>A prospective, cross-sectional study including existing CL wearers was conducted. Symptoms were assessed with a comfort visual analog scale (VAS) and the Contact Lens Dry Eye Questionnaire-8. In-vivo corneal confocal microscopy was used to track immune cell dynamics over 3 timepoints at 5-minute intervals. Trajectory speed was calculated as the total length travelled by cells divided by time; displacement speed as the straight-line distance between the start and end positions of a cell divided by time; and persistence ratio as the ratio of displacement speed and trajectory speed. Measurements were performed for 1-3 cells per participant, and the minimum, maximum, and average values were analyzed. Tear film samples were collected to assess matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinase (TIMP)-1, and the MMP-9/TIMP-1 ratio. Correlations between immune cell dynamics, symptoms, and tear inflammatory mediators, were analyzed.</p><p><strong>Results: </strong>Nineteen CL wearers (4 men and 15 women) aged 30 ± 5 years were included. Participants wore silicone hydrogel CLs for 8-10 h before clinical assessment. There was a significant association between comfort VAS and the maximum (rho = 0.533; p = 0.019) and average (rho = 0.506; p = 0.027) values of immune cell displacement speed. The concentration of MMP-9 was associated with the minimum value of trajectory speed (rho = 0.621; p = 0.031). Finally, the MMP-9/TIMP-1 ratio was associated with the maximum value of trajectory speed (rho = -0.717; p = 0.030), and the maximum (rho = -0.720; p = 0.008) and average (rho = -0.678; p = 0.015) values of displacement speed.</p><p><strong>Conclusion: </strong>Corneal immune cell dynamics is related to sensations of discomfort in silicone hydrogel CL wearers, with cell speed possibly being regulated by inflammatory mediators assessed from the tear film. These observations may aid in understanding the mechanisms underlying the discomfort response.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102424"},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between disinfectant resistance genes in exoU and exoS Pseudomonas aeruginosa with sensitivity to multipurpose disinfecting solutions and antibiotics.","authors":"Tanzina Akter, Fiona Stapleton, Matthew Green, Mark Willcox","doi":"10.1016/j.clae.2025.102436","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102436","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to determine differences in susceptibility of exoU and exoS Pseudomonas aeruginosa to multi-purpose disinfecting solutions (MPDS) and antibiotics and their association with disinfectant resistance genes.</p><p><strong>Methods: </strong>A total of 16 exoU and 24 exoS P. aeruginosa keratitis isolates were tested for susceptibility against four multipurpose disinfecting solutions (OPTI-FREE PureMoist, Acuvue RevitaLens, Biotrue, and Renu Advanced Formula) using minimum inhibitory (MIC) and minimum bactericidal (MBC) concentrations. Antibiotic susceptibility to ciprofloxacin, levofloxacin, gentamicin, and tobramycin was determined by MIC. Whole genome sequences from 27 isolates were utilized to identify disinfectant resistance genes and single nucleotide polymorphisms (SNPs) in the genes using the Comprehensive Antibiotic Resistance Database (CARD) and Geneious Prime respectively. Polymerase chain reaction (PCR) was used to detect the disinfectant resistance genes qacE, qacEΔ1, and sugE1. Correlation between disinfectant resistance genes and their SNPs with disinfectant and antibiotic MICs was determined by Spearman's Rho.</p><p><strong>Results: </strong>All MPDS were bactericidal at full strength, but upon dilution OPTI-FREE Puremoist and Renu Advanced Formula were the most active against the exoU and exoS groups correspondingly. ExoU showed significantly higher resistance than exoS (p ≤ 0.04) to levofloxacin (37.5 % vs. 8.3 %), gentamicin (43.8 % vs. 0 %), and tobramycin (37.5 % vs. 0 %). The qacEΔ1 and sugE1 genes along with several SNPs in the resistance genes were more common in the exoU group. SNPs in disinfectant resistance genes correlated with MPDS MICs/MBCs, notably mexQ Arg1036His (R ≥ -0.38, p ≤ 0.04), Gly505Asp (R ≥ 0.40, p ≤ 0.04) and opmD Gly269Ser (R ≥ 0.43, p ≤ 0.03). QacEΔ1 and sugE1 were linked to increased MIC (R ≥ 0.54, p < 0.01) and MBC (R ≥ 0.50, p < 0.01) for Renu Advanced Formula. Also, multiple SNPs and qacEΔ1 and sugE1 showed moderate to large positive associations with antibiotic resistance.</p><p><strong>Conclusions: </strong>ExoU strains had distinct MPDS susceptibility patterns, with higher disinfectant resistance genes prevalence and mutations, contributing to MPDS and antibiotics resistance.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102436"},"PeriodicalIF":4.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of soft contact lenses on the corneal neuromediators and optical quality in high myopia.","authors":"Yuhao Shao, Min Li, Wei Wang, Yuehui Shi, Lina Sun, Yiyong Qian, Xiaoyun Ma, Jun Zou","doi":"10.1016/j.clae.2025.102425","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102425","url":null,"abstract":"<p><strong>Background: </strong>To investigate the impact of long-term soft contact lenses (SCLs) wear on corneal neuromediators within stromal lenticules and its effect on optical quality.</p><p><strong>Methods: </strong>This study enrolled 140 eyes from 70 patients with high myopia who underwent small incision lenticule extraction (SMILE). Participants were divided into three groups according to the duration of SCLs wear: > 10 years group, ≤ 10 years group, and a non-wearing group (NW). Corneal higher-order aberrations and densitometry were assessed using a Pentacam system. Levels of Neuromediators in stromal lenticules were measured via enzyme-linked immunosorbent assay (ELISA) and immunofluorescence analysis. The relationships among SCLs wear duration, neuromediator levels, and optical quality parameters were evaluated through multiple comparative analyses.</p><p><strong>Results: </strong>The levels of nerve growth factor (NGF), substance P (SP), and mesencephalic astrocyte-derived neurotrophic factor (MANF) were significantly elevated in SCLs wearers. In comparison to the NW group, corneal densitometry values within the 0-6 mm zone were obviously higher in both the ≤ 10 years and > 10 years groups. The total higher-order aberrations and horizontal coma were observed to be increased in the > 10 years group. Significant correlations were found between NGF levels and corneal densitometry values in the anterior layer at the 0-2  mm and 2-6  mm zones in the > 10 years group, as well as between insulin-like growth factor binding protein-1 (IGFBP-1) levels and corneal densitometry values in the the central layer's 0-2  mm zone in the NW group.</p><p><strong>Conclusions: </strong>The prolonged wear of SCLs in individuals with high myopia may result in an increase in the levels of corneal stromal neuromediators and a deterioration in corneal optical quality. Notably, neuromediators are significantly associated with corneal optical quality.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102425"},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scleral lens prescribing trends in a large specialty contact lens practice in the Netherlands.","authors":"D J van Ooik, N Soeters, W A C Krijgh, E S Visser","doi":"10.1016/j.clae.2025.102426","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102426","url":null,"abstract":"<p><strong>Purpose: </strong>To report scleral lens prescribing trends in a large specialty contact lens practice in the Netherlands.</p><p><strong>Methods: </strong>In this retrospective cohort study, data of all scleral lens orders between 2016 and 2022 were collected. Patient demographics, scleral lens design, scleral lens parameters and one lens order per eye per fitting period were analysed. All scleral lenses were fitted using the Visser fitting philosophy with diagnostic trial sets.</p><p><strong>Results: </strong>In total, 27,430 scleral lenses for 6,635 unique patients were evaluated, of which 2,594 unilateral cases, 16,685 mini-scleral lens designs (60.8 %) and 10,745 large scleral lens designs (39.2 %). Median patient age at the time of the initial order was 43 years (range 3-95) and 53.4 % were male. Keratoconus patients were the youngest group (median 35 years, range 9-83). For all indications, except for keratoplasty, the proportion of mini-scleral versus large scleral lens design increased significantly over time (44 % in 2016, 74 % in 2022). The ratio of tangential versus curved landing zones was 10:1 in mini and 1:1 in large scleral lens design. Both lens design landing zones were toric in 99.8 % of all cases. The median (range) flattest tangent of the landings zone was 38 (16-58) degrees (mini-scleral lens design) and 44 (37-53) (large scleral lens design). The median (range) flattest curve of the landing zone for the large scleral lens was 12.5 (10.5-13.8). Median sagittal depth was 3.5 versus 4.3 mm, median BOZR was 8.6 versus 8.2 mm and median diameter was 16 versus 20 mm in mini and large scleral lens designs, respectively. The mean number of lenses (±SD) ordered for a successful new fit for all designs combined was 1.4(±0.7).</p><p><strong>Conclusion: </strong>A notable result of this study was the predominant use of toric scleral lens landing zones. During the study period the prescribing trend shifted from large towards mini-scleral lens designs. The fitting strategy with diagnostic trial sets resulted in high success rates with low numbers of re-orders.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102426"},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double Iris, A case report.","authors":"Ahmed Shakir Ali Al-Wassiti, Ali Majeed Rashed, Mohammed Tareq Mutar","doi":"10.1016/j.clae.2025.102423","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102423","url":null,"abstract":"<p><p>The formation of the iris involves interactions between the neural ectoderm, neural crest-derived cells, and the mesoderm. This report describes the occurrence of double iris in a patient and describes the clinical profile for him. The study presents a case of 31-year-old male with a history of blurred vision in the left eye since childhood. His left eye (OS) was amblyopic with a VA of 6/60. There was hypermetropia in the left eye and intraocular pressure (IOP) was within the normal range. Anterior chamber (AC) showed no signs of inflammation, and the vitreous was clear. The slit lamp examination revealed double iris bilaterally that was confirmed using an optical coherence tomography.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102423"},"PeriodicalIF":4.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient considerations versus actual reasons for contact lens cessation: Insights from a survey-based study.","authors":"Antonio Ballesteros-Sánchez, Joan Gispets, Aurora Torrents","doi":"10.1016/j.clae.2025.102421","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102421","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze and compare non-contact lens-related and contact lens-related reasons influencing cessation considerations in current contact lens wearers (CLWs) with the actual reasons for cessation reported by discontinued CLWs.</p><p><strong>Methods: </strong>This was an cross-sectional study with face-to-face survey administered to current and discontinued CLWs by trained optometrists at the General Óptica centers across Spain. The survey included basic demographic information, and explored both non-contact lens-related and contact lens-related reasons that led current CLWs to consider cessation or resulted in cessation among discontinued CLWs.</p><p><strong>Results: </strong>A total of 1266 surveys, including 764 from current CLWs and 502 from discontinued CLWs, were included. Regarding non-contact lens-related reasons for cessation, discontinued CLWs more frequently reported a \"Preference for wearing spectacles\" (13.1 % vs. 3.8 %, P < 0.05) and \"Recommendation by an eye care practitioner\" (5.2 % vs. 0.6 %, P < 0.05), while current CLWs more often cited \"Refractive surgery\" (15.8 % vs. 9.4 %, P < 0.05). For contact lens-related reasons for cessation, discontinued CLWs more frequently reported \"Difficulty handling contact lenses\" (10.6 % vs. 1.9 %, P = 0.001), whereas current CLWs more commonly cited \"Contact lens-related ocular symptoms\" (57.6 % vs. 43.8 %, P < 0.05). Agreement between groups was generally low for all reasons analyzed, ranging from -0.115 to 0.103.</p><p><strong>Conclusions: </strong>The reasons for cessation from the perspective of current and discontinued CLWs yield different results. By addressing the reasons considered by current CLWs, while taking into account the reasons most strongly associated with cessation in discontinued CLWs, eye care practitioners could proactively prevent CL cessation.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102421"},"PeriodicalIF":4.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPLY TO Effectiveness of orthokeratology and myopia control spectacles in a real-world setting in China","authors":"Bi Yang ,&nbsp;Longqian Liu ,&nbsp;Pauline Cho","doi":"10.1016/j.clae.2025.102420","DOIUrl":"10.1016/j.clae.2025.102420","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102420"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing medicinal maggot excretions/secretions for the ocular surface: A mini review.","authors":"Ebenezer Owusu, Rachel L Redfern","doi":"10.1016/j.clae.2025.102422","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102422","url":null,"abstract":"<p><p>Ophthalmology could significantly benefit from the therapeutic potential of medicinal maggots, which have been extensively utilized in dermatology for wound healing and infection management. This article reviews the evidence supporting the potential translation of maggot excretions/secretions (ES) for treating ocular surface wounds and infections. It examines the challenges associated with treating ocular surface wounds and infections, the established role of medicinal maggots in chronic skin wound care, and the composition and biological properties of maggot ES. Furthermore, recent research on the impact of maggot ES on the ocular surface is highlighted, along with future research directions necessary to effectively harness its bioactive components for ocular surface-related treatments.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102422"},"PeriodicalIF":4.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of definition of meibomian gland dysfunction on the frequency of MGD in dry eye disease from the DREAM© study.","authors":"Divya Jagadeesh, Meng C Lin, Fiona Stapleton, Jocelyn He, Gui-Shuang Ying, Penny Asbell","doi":"10.1016/j.clae.2025.102416","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102416","url":null,"abstract":"<p><strong>Purpose: </strong>Meibomian gland dysfunction (MGD) is a common disease, yet there is no standard clinical definition. This study explored the frequency and characteristics of MGD in dry eye disease (DED) using different clinical definitions.</p><p><strong>Methods: </strong>A secondary analysis of data collected from the DREAM© study participants (n = 535) with moderate-to-severe DED was undertaken. Three common MG clinical features; plugging, secretion quality, and MG atrophy grade, either separately or in combination were used to create MGD definitions. The frequency of MGD, defined by the per eye findings, was reported. Demographic characteristics were compared between those with and without MGD.</p><p><strong>Results: </strong>The frequency of MGD in DED varied from 12 % (gland plugging, plus poor secretion quality plus gland atrophy) to 55 % (gland plugging alone) of eyes. Older age was associated with MGD when atrophy-based definitions were used (p < 0.001) but was not associated with MGD definitions using plugging or secretion quality (p > 0.05). After adjustment for age and between-eye correlations, MGD frequency was higher in women for definitions based on lower lid gland atrophy (adjusted p < 0.05). Hispanic or Latino ethnicity was more commonly associated with MGD than other ethnicities (adjusted p < 0.001), for definitions based on plugging and secretion quality.</p><p><strong>Conclusion: </strong>The frequency of MGD in DED varied with MGD definition. The highest frequency occurred where MGD was defined as lower eyelid gland plugging. Gland atrophy increased with age. The variation in disease frequency has implications for clinical diagnosis and determining efficacy assessment in intervention studies.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102416"},"PeriodicalIF":4.1,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 265 nm ultraviolet C light in the treatment of multi-drug resistant Pseudomonas aeruginosa keratitis in vitro and in an in vivo murine model","authors":"Lakshminarayanan Gowtham ,&nbsp;Esther Sheba ,&nbsp;Savitri Sharma ,&nbsp;Dilip Kumar Mishra ,&nbsp;Bhupesh Bagga","doi":"10.1016/j.clae.2025.102417","DOIUrl":"10.1016/j.clae.2025.102417","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the <em>in vitro</em> and <em>in vivo</em> efficacy of 265 nanometer (nm) ultraviolet C (UVC) light using 1.93 mW/cm² against multi-drug-resistant (MDR) <em>Pseudomonas aeruginosa</em> (<em>P. aeruginosa</em>) keratitis.</div></div><div><h3>Methods</h3><div>The effect of UVC light was studied on two clinical isolates of <em>P. aeruginosa</em>. Isolate 1 was ciprofloxacin-susceptible, and isolate 2 was MDR (but ceftazidime-susceptible). For the <em>in vitro</em> evaluation, <em>P. aeruginosa</em> isolates (100 μl, 1*10⁸ CFU/ml) were spread on Muller-Hinton solid agar surface and exposed to UVC light for 1, 5, 10, 15, and 30 seconds (s). For the <em>in vivo</em> study, the right eyes of C57BL mice were infected with the <em>P. aeruginosa</em> isolates (5 μL, 1*10⁸ CFU/ml) in two sets with isolates 1 and 2, respectively. The first set (n = 24) was randomized into four groups: a) untreated, b) UVC light 15 s exposure twice daily for two days, c) topical ciprofloxacin 0.3 %w/v twice daily for two days, d) topical ciprofloxacin 0.3 %w/v two-hourly for two days. The second set with MDR <em>P. aeruginosa</em> (n = 24) was treated similarly except for group d (which received topical ceftazidime 5 %w/v two hourly for two days). The left eyes were used to evaluate the safety of applied treatments without inducing infection. At 48 hours (hrs), eyes were enucleated and subjected to microbiological and histopathology analysis.</div></div><div><h3>Results</h3><div><em>In vitro</em>, the UVC light exposure resulted in a clear inhibition area for exposures of 15 and 30 s. In the <em>in vivo</em> murine model, UVC light prevented overall clinical severity (p &lt; 0.05) at 24 and 48 hrs by both isolates. Microbiological assessment at 48 hrs showed no growth of organisms in UVC light-treated corneas of either of the sets, similar to an observed treatment with ciprofloxacin (set 1) and ceftazidime (set 2).</div></div><div><h3>Conclusion</h3><div>265 nm UVC light showed an exposure-dependent <em>in vitro</em> bactericidal effect on <em>P. aeruginosa</em>. The <em>in vivo</em> studies showed that UVC light eliminated both strains of <em>P. aeruginosa</em> with an equivalent efficacy.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102417"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}