Contact Lens & Anterior Eye最新文献

{"title":"Therapeutic effect of intense pulsed light in ocular demodicosis: A systematic review and meta-analysis.","authors":"Hsin-Ming Liu, Shannon Su, Cher-Ming Liou, Ann Yi-Chiun Chuang","doi":"10.1016/j.clae.2025.102477","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102477","url":null,"abstract":"<p><strong>Aims: </strong>To assess the effect of intense pulsed light (IPL) on reducing ocular demodicosis.</p><p><strong>Methods: </strong>A systematic literature search was conducted up to March 8, 2025, using the PubMed, Embase, Google Scholar, and Cochrane Central Register of Controlled Trials databases. Randomized controlled trials (RCTs) or non-RCTs with Demodex measurements before and after IPL therapy were included.</p><p><strong>Results: </strong>Six trials (five RCTs + one non-RCT) involving 329 adults were included. The overall risk of bias was assessed as low to moderate, and the certainty of evidence for all outcomes was considered low. IPL reduced Demodex mites per 100 eyelashes, with a mean difference (MD) of -7.80 (-16.36 to 0.76) with moderate heterogeneity (p = 0.11, I² = 47 %) when considering only RCTs. The risk ratio of Demodex eradication was 1.41 (1.18 to 1.69, I² = 0 %, p = 0.72) and was significant in both the IPL with meibomian gland expression (MGX) subgroup (1.49, 1.17-1.91) and IPL alone subgroup (1.32, 1.02-1.72). No major adverse events were reported.</p><p><strong>Conclusion: </strong>IPL, either alone or in combination with MGX, demonstrates a trend toward reducing Demodex infestation with no major adverse events reported. However, its effect on mite count reduction has not reached statistical significance. Further studies are needed to establish an optimal IPL treatment protocol.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102477"},"PeriodicalIF":4.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular pressure following long-term scleral lens wear in Chinese eyes.","authors":"Maoyuan Yang, Feifu Wang, Aiqin Xu, Qiaochu Yang, Ming Cao, Chen Bichi, Ruzhi Deng, Jun Jiang, Stephen J Vincent","doi":"10.1016/j.clae.2025.102476","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102476","url":null,"abstract":"<p><strong>Purpose: </strong>Since the prevalence of glaucoma is greater in Asian populations, the purpose of this study was to investigate variations in intraocular pressure (IOP) following long-term scleral lens wear in Chinese eyes.</p><p><strong>Methods: </strong>This prospective, observational clinical study included 60 Chinese participants with irregular corneas (irregular cornea group, ICG) and regular corneas (regular cornea group, RCG). Following a baseline examination and scleral lens fitting and dispensing, follow-up visits were conducted after 1 week, 1 month, and 3 months of scleral lens wear. IOP was measured without the lens on eye using rebound tonometry (ICG) or non-contact tonometry (RCG).</p><p><strong>Results: </strong>In both the RCG and ICG, the mean IOP varied by < ± 0.3 mmHg across study visits (p > 0.05). A small number of participants (RCG n = 3, ICG n = 3, i.e. 10% of eyes) exhibited an IOP elevation of ≥ 2 mmHg from baseline across two consecutive study visits, including the final 3 month visit.</p><p><strong>Conclusion: </strong>On average, IOP remained stable (mean changes < ± 0.3 mmHg) in Chinese participants with regular and irregular corneas following three months of scleral lens wear. Future long-term scleral lens studies examining changes in IOP with the lens in situ (e.g., using pneumotonometry), anterior chamber anatomy, or optic nerve parameters in Chinese populations are warranted given the higher prevalence of glaucoma in Asian eyes.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102476"},"PeriodicalIF":4.1,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydration and physicochemical changes in myopia control contact lenses: influence of material and maintenance solutions.","authors":"Veronica Noya-Padin, Hugo Pena-Verdeal, Pedro V Rodrigues, Ana Vera Machado, Eva Yebra-Pimentel, Madalena Lira","doi":"10.1016/j.clae.2025.102478","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102478","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the dehydration rate in different myopia control contact lenses (CLs) and the physicochemical changes that occur after exposure to different maintenance solutions.</p><p><strong>Methods: </strong>First, the dehydration rate of CLs and its impact on refractive index and diameter were evaluated in three myopia control CLs models (MiSight 1 Day, Bloom Day, and MYLO). Measurements were taken immediately after the CL was removed from the blister and at 5-min intervals over a 30-min period. Second, the effect of different maintenance solutions on the physicochemical properties of monthly replacement myopia control CLs (MYLO) with different diameters were assessed. Refractive index, water content, diameter, lens surface hydrophobicity, and dynamic mechanical properties were measured immediately after the CL was removed from the blister and again after 12 h of immersion in each of the three maintenance solutions studied (Hidro Health HA, OPTI-Free PureMoist and Biotrue).</p><p><strong>Results: </strong>The dehydration rate exhibited significant disparities among the CLs examined, with daily replacement CLs (MiSight 1 Day and Bloom Day) demonstrating the fastest dehydration and, consequently, the most significant change in refractive index. In contrast, MYLO CLs exhibited the greatest reduction in diameter. When assessing the impact of maintenance solutions on MYLO properties, changes were observed in all evaluated parameters, except for mechanical properties. These changes varied depending on the maintenance solution used and the diameter of CL.</p><p><strong>Conclusion: </strong>Myopia control CLs can undergo dehydration and changes due to the solutions used for their care, which may significantly affect their physicochemical properties, lens performance, comfort, and stability. Therefore, careful consideration should be given to the properties of the CL material and the maintenance solutions properties to optimize the user experience and ensure consistent lens behavior over time.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102478"},"PeriodicalIF":4.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific clinical phenotypes of dry eye disease can predict the presence of matrix metalloproteinase-9 in the ocular surface.","authors":"Germán Mejía-Salgado, William Rojas-Carabali, Carlos Cifuentes-González, Luis Alejandro Diez-Bahamón, Valentina Kerguelén-Dumar, Juanita Téllez-Zambrano, Juan José García-Madero, Alejandro Guevara-Carvajal, Martha Lucía Moreno-Pardo, Juliana Tirado-Ángel, Guillermo Marroquín-Gómez, Anat Galor, Alejandra de-la-Torre","doi":"10.1016/j.clae.2025.102475","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102475","url":null,"abstract":"<p><strong>Objective: </strong>The InflammaDry test detects matrix metalloproteinase-9 (MMP-9) in tears, a biomarker associated with ocular surface inflammation. While a positive result may indicate the need for anti-inflammatory therapy, its cost and qualitative nature limit widespread use. This study aims to identify clinical phenotypes that predict positive InflammaDry results, facilitating targeted anti-inflammatory therapy without requiring MMP-9 testing.</p><p><strong>Methods: </strong>This retrospective study analyzed 1,363 patients with Dry Eye Disease (DED) from a dry eye clinic. Diagnosis was based on symptoms and at least one tear dysfunction sign. All patients underwent InflammaDry testing. Bivariate analysis (Chi-square, Student's t-test, Mann-Whitney-U) identified clinical factors associated with test positivity, which were further analyzed in a multivariable model. The proportion of InflammaDry-positive patients was compared across groups with increasing numbers of risk factors.</p><p><strong>Results: </strong>The mean age of the population was 51.4 years; 84.1 % were female, and all were Hispanic. Multivariable analysis identified several significant predictors of positive InflammaDry results: the presence of any autoimmune or allergic disease (odds ratio, OR = 1.59), corneal staining (Oxford ≥3, OR = 2.41), conjunctival staining (Oxford ≥3, OR = 2.30), low tear film viscosity (OR = 1.55), and nasal (OR 1.80) or temporal (OR = 1.47) ocular redness (Jenvis score >2 by Oculus). The frequency of a positive InflammaDry increased from 69.9 % in the total population (n = 1,363) to 100 % in those with three identified risk factors (n = 9).</p><p><strong>Conclusion: </strong>Specific systemic and ocular phenotypes can predict InflammaDry test results. Patients with specific characteristics may not require MMP-9 testing due to the high likelihood of having a positive result, potentially leading to more targeted and cost-effective management strategies.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102475"},"PeriodicalIF":4.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of attitudes and clinical behaviour of UK eyecare practitioners towards fitting contact lenses for children and young people.","authors":"Sophie Coverdale, Edward Mallen, Matthew Cufflin, Michael Bowen, Teresa Lewandowski, Neema Ghorbani-Morjarrad","doi":"10.1016/j.clae.2025.102470","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102470","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored the attitudes and prescribing behaviours of UK eyecare practitioners (ECPs) toward fitting contact lenses (CLs) for patients under 18, and whether these have been influenced by the growing availability of myopia control options.</p><p><strong>Methods: </strong>An online survey was conducted in 2023 with UK-based optometrists and contact lens opticians (CLOs). It examined minimum fitting ages for different CL types, key decision-making factors when prescribing for paediatrics, and changes in practitioners' willingness to fit CLs for children. Comparisons were made to a prior iteration of the survey in 2014.</p><p><strong>Results: </strong>A total of 316 ECPs (248 optometrists, 68 CLOs) completed the survey, with a median of 16 years of experience. Patients under age 18 comprised an estimated 37.2 % of respondents' CL patients, dropping to 6.2 % for those under age 10. All respondents considered soft CLs suitable for under-18 s, with a median starting age of 8-9 years; rigid corneal lenses were deemed suitable from a significantly higher age of 10-12 years (p < 0.001). CLOs were more willing than optometrists to fit both lens types at earlier ages (p < 0.05) and rated a child's age as less influential in decision-making (4.9/10 vs. 6.2/10 respectively, p < 0.001). In general, the child's motivation was the most important factor (9.1/10), while sex was the least (1.8/10). Myopia control was a key consideration (8.4/10), and 38.6 % of ECPs said they had greater willingness to fit CLs for children due to increased access to myopia control options. The proportion of optometrists willing to fit a child under age 8 increased from 12.7 % in 2014 to 39.1 % in 2023.</p><p><strong>Conclusions: </strong>UK ECPs are generally supportive of CL wear in under-18 s, with myopia control increasingly influencing prescribing. CLOs appear more proactive in paediatric fittings, suggesting a need to enhance optometrists' training to improve confidence in prescribing for younger patients.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102470"},"PeriodicalIF":4.1,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Be a force for good","authors":"Dwight Akerman","doi":"10.1016/j.clae.2025.102469","DOIUrl":"10.1016/j.clae.2025.102469","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 5","pages":"Article 102469"},"PeriodicalIF":3.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of DIMS combined with atropine and orthokeratology in a real-world setting in China.","authors":"Desheng Song, Yanxu Chen, Jiaqi Yao, Juan Chen","doi":"10.1016/j.clae.2025.102473","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102473","url":null,"abstract":"<p><strong>Background and objectives: </strong>Myopia cases have markedly increased worldwide, particularly in younger individuals. This study evaluatestheeffectofdefocus incorporated multiple segments (DIMS) lens combined with atropine (DIMSA) in the control of myopia progression versus orthokeratology (ortho-k) lenses.</p><p><strong>Methods: </strong>In this non-randomized controlled clinical study, 180 eyes in 180 myopic children treated at the Nanjing Children's Hospital between January 2022 and February 2023 were included. According to the preferences of patients and their guardians, the participants were divided into the DIMSA and ortho-k groups, with 90 cases (90 eyes) each. Totally 161 patients in both groups met the inclusion and exclusion criteria, including 88 and 73 in the DIMSA and ortho-k groups, respectively. Right eye parameters were analyzed. Both groups were compared in terms of change in axial length (AL), AL negative growth rate and AL elongation rate after a one-year visit.</p><p><strong>Results: </strong>No significant differences were found in baseline features other than age between the DIMSA and ortho-k groups. After a one-year treatment, no statistically significant difference was found in axial elongation (AE) between the two groups. After adjustment for baseline age, axial elongations in the DIMSA and ortho-k groups were 0.14 ± 0.18 mm and 0.20 ± 0.18 mm (P = 0.025), respectively. Baseline age was the only factor impacting the axial control efficacy of DIMSA and ortho-k lenses, with a negative association between AE and age in both groups and a positive association between spherical equivalent refraction (SER) increase and baseline age in the DIMSA group. The DIMSA group exhibited higher AL negative growth and AL slow growth (≤0.15 mm) rates after one year compared with the ortho-k lens group (P = 0.008 and P = 0.004, respectively).</p><p><strong>Conclusions: </strong>DIMSA demonstrated marginally superior myopia control efficacy compared to ortho-k lenses in children with mild to moderate myopia in a real-world setting in China.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102473"},"PeriodicalIF":4.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Demodex activity of castor oil confirmed in an ex vivo study.","authors":"Catherine J Jennings, Jordan M Cooper, Kalika Bandamwar, Etty Bitton, Jennifer P Craig","doi":"10.1016/j.clae.2025.102471","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102471","url":null,"abstract":"<p><strong>Purpose: </strong>Periocular castor oil application shows possible benefits in managing Demodex blepharitis based on visibly reduced cylindrical dandruff at the base of the eyelashes, but the antidemodectic mechanism remains unclear. This research sought to establish Demodex mite susceptibility to castor oil directly in a controlled, ex vivo study.</p><p><strong>Methods: </strong>Motile Demodex mites from epilated eyelashes with visible cylindrical dandruff were exposed to 5 µL aliquots of one of four castor oil or tea tree oil-based preparations, or remained unexposed (negative control). Adult Demodex mite motility was confirmed by high magnification microscopy every 5 min for up to 480 min post-exposure and survival time recorded when movement ceased. Tested oils were 100% cold-pressed castor oil, a proprietary castor oil preparation containing identical castor oil combined with manuka and kanuka oils, and 100% and 50% tea tree oil as positive controls.</p><p><strong>Results: </strong>Survival time in the negative control group exceeded 480 min. All tested oils exhibited shortened mite survival time relative to the negative control (p < 0.05 in all cases). Survival times for 59 mites from 12 participants were plotted for the 5 experimental groups. Undiluted and proprietary castor oil preparations exhibited median (interquartile range; IQR) survival times of 235 (200-285) and 325 (240-405) minutes, respectively, with no significant difference between groups (p > 0.05). A single mite from each castor oil group survived beyond 480 min. Positive controls exhibited median (IQR) survival times of 5 (5-10) mins for 100% tea tree oil and 20 (15-25) mins, for 50% tea tree oil.</p><p><strong>Conclusions: </strong>Castor oil alone, or in proprietary form supplemented with manuka and kanuka oils, reduced Demodex survival over an 8-hour period. Outcomes suggest extended duration exposure to castor oil, such as in overnight application, has demodecidal activity that could contribute to Demodex blepharitis management.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102471"},"PeriodicalIF":4.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: is the elimination of keratoconus in our hands?","authors":"Alejandro Tello, Virgilio Galvis","doi":"10.1016/j.clae.2025.102472","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102472","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102472"},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of publication bias on the evidence supporting the use of myopia control interventions.","authors":"Giulia Carlotta Rizzo, Lorenza Scotti, Alberto Recchioni, Erika Ponzini, Fabrizio Zeri, Silvia Tavazzi, Jonathan Denniss, Riccardo Cheloni","doi":"10.1016/j.clae.2025.102463","DOIUrl":"10.1016/j.clae.2025.102463","url":null,"abstract":"<p><strong>Purpose: </strong>Publication bias exists when studies with negative results are less likely to be published, resulting in over-estimation of treatment efficacy. This study aimed to assess the impact of publication bias on current evidence supporting myopia control interventions.</p><p><strong>Methods: </strong>A systematic literature search was conducted to retrieve systematic-reviews (SRs) and meta-analyses (MAs) assessing myopia control interventions. From eligible SRs & MAs randomised controlled trials (RCTs) evaluating myopia control treatments (spectacle-based, contact lenses (CL), pharmacological) were included. Outcomes were mean changes in axial-length and refractive error. Pooled estimates of efficacy were computed with random effects meta-analysis. Publication bias was evaluated with funnel plots and Egger's test.</p><p><strong>Results: </strong>This study included 27 SRs and MAs, reporting on 49 eligible RCTs. Considering axial length outcomes, there were 41 RCTs, assessing CL (n = 16, 39 %), spectacles (n = 13, 31.7 %), and pharmacological treatments (n = 12, 29.3 %). Egger's test was significant only for pharmacological treatments (p = 0.045), but trim and fill analysis indicated that that treatment efficacy was not over-estimated. Of 46 RCTs considering refractive error outcomes, 13 (28.3 %), 14 (30.4 %), and 19 (41.3 %) examined CL, pharmacological and spectacle treatments, respectively. Egger's test showed significant asymmetry only for CL (p = 0.006), but there was not over-estimate of treatment efficacy. Among specific treatments, only atropine (refractive outcomes) and multifocal CL (axial length and refractive outcomes) had sufficient RCTs for analysis, and all Egger's test were not significant (all p > 0.05).</p><p><strong>Conclusions: </strong>This study did not find evidence of publication bias affecting the current literature supporting myopia control treatments, suggesting that the effect of different interventions is unlikely to be overestimated.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102463"},"PeriodicalIF":4.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}