Contact Lens & Anterior Eye最新文献

{"title":"Obituary: Professor Michael J. Doughty","authors":"Eilidh Martin, Sven Jonuscheit, Lyle S. Gray, Shehzad A. Naroo","doi":"10.1016/j.clae.2026.102699","DOIUrl":"10.1016/j.clae.2026.102699","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102699"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Effect of orthokeratology on ocular dominance in Chinese myopic children: a 1-year longitudinal study”","authors":"Zhikuan Yang","doi":"10.1016/j.clae.2026.102660","DOIUrl":"10.1016/j.clae.2026.102660","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102660"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial changes and long-term myopia progression with orthokeratology: A risk-stratification study","authors":"Xin Ai,&nbsp;Ruoxin Wang,&nbsp;Yanhong Li,&nbsp;Xuehui Zhang","doi":"10.1016/j.clae.2026.102693","DOIUrl":"10.1016/j.clae.2026.102693","url":null,"abstract":"<div><h3>Purpose</h3><div>To analyze long-term changes in axial length and anterior segment parameters among children wearing orthokeratology lenses and screen indicators correlated with 5-year myopia progression risk.</div></div><div><h3>Methods</h3><div>A retrospective study enrolled 61 children with 5-year follow-up after orthokeratology lens fitting. Participants were stratified into a slow progression group (<em>n</em> = 32, 5-year axial length elongation ΔAL₅ &lt; 1 mm) and a rapid progression group (<em>n</em> = 29, ΔAL₅ ≥ 1 mm). The axial length, lens thickness, anterior chamber depth, and central corneal thickness were monitored from baseline to 5 years. Correlation analysis, ROC curve analysis, multivariate binary logistic regression, and repeated-measures ANCOVA were performed for statistical analysis.</div></div><div><h3>Results</h3><div>Baseline age was the only parameter that showed significant intergroup differences (<em>P</em> &lt; 0.001). ΔAL₁ to ΔAL₄ were positively correlated with ΔAL₅ (all P &lt; 0.001). ΔAL₁ yielded an AUC of 0.860 (95% CI: 0.761–0.960) with an optimal cutoff of 0.155 mm, and ΔAL₃ achieved an AUC of 0.907 (95% CI: 0.829–0.984) with an optimal cutoff of 0.480 mm. ΔLT₃ to ΔLT₄ were negatively correlated with ΔAL₅ (<em>P</em> &lt; 0.05, AUC = 0.704). Significant time–group interactive effects were detected in axial length, anterior chamber depth, lens thickness, and central corneal thickness (all <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Early and mid-term axial length variations are strongly associated with long-term myopia progression under orthokeratology intervention. Axial elongation exceeding 0.480 mm at year 3 indicates a high risk of rapid myopia progression, and 1-year axial growth exceeding 0.155 mm facilitates early risk stratification.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102693"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148310137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The answer is 23 years - what is the question? Understanding the time lag between ophthalmic research and clinical adoption","authors":"James S. Wolffsohn,&nbsp;Philip Morgan","doi":"10.1016/j.clae.2026.102697","DOIUrl":"10.1016/j.clae.2026.102697","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102697"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of corneoscleral topographic consistency in eyes with low-to-moderate and high astigmatism","authors":"Ziwei Xiang,&nbsp;Danjie Han,&nbsp;Dantong Gu,&nbsp;Yishan Qian,&nbsp;Zhi Chen","doi":"10.1016/j.clae.2026.102688","DOIUrl":"10.1016/j.clae.2026.102688","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to compare the corneoscleral topographic consistency between eyes with low-to-moderate and high refractive astigmatism (RA).</div></div><div><h3>Methods</h3><div>A total of 131 eyes of 69 participants with astigmatism (51 females and 18 males) and no ocular diseases or history of ocular surgery were included in this study. Participants were divided into a low-to-moderate astigmatism (LMA) group (|RA| ≤ 2.50 D; mean 1.57 ± 0.71 DC; <em>n</em> = 94 eyes) and a high astigmatism (HA) group (|RA| &gt; 2.50 D; mean 3.72 ± 1.08 DC; <em>n</em> = 37 eyes). Corneoscleral topography was acquired via Anterior Segment Analyzer (Scansys TA517). The measurement repeatability at 8-mm and 14-mm chord lengths was examined using Bland-Altman approach. Intraclass correlation coefficient (ICC) between the corneal and scleral shapes was used to calculate corneoscleral topographic consistency. Inter-eye ICC of corneoscleral shape were compared in participants exhibiting a marked interocular astigmatic asymmetry (≥ 1.50 DC).</div></div><div><h3>Results</h3><div>The 8-mm chord lengths demonstrated superior repeatability, with narrower limits of agreement (LoA: 0.356 ± 0.029 mm; range 0.312 to 0.406 mm) compared to the 14-mm chord (LoA: 0.541 ± 0.058 mm; range 0.429 to 0.648 mm). The eyes with HA showed stronger corneoscleral topographic consistency (mean ICC = 0.54 ± 0.19) than those with LMA (mean ICC = 0.34 ± 0.37, <em>t</em> = −3.96, <em>p</em> &lt; 0.001). In participants with interocular astigmatic asymmetry, the eye with greater astigmatic power exhibited a significantly higher corneoscleral topographic consistency (mean ICC = 0.67 ± 0.20) than the contralateral eye (mean ICC = 0.32 ± 0.24, <em>t</em> = 3.09, <em>p</em> = 0.01).</div></div><div><h3>Conclusion</h3><div>Eyes with HA exhibited greater corneoscleral topographic consistency than those with LMA. This finding may help with scleral lens fitting in participants with corneal and refractive astigmatism in the absence of scleral shape data.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102688"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What guides treatment decisions in dry eye disease: Signs or symptoms?","authors":"Kaleb S. Abbott,&nbsp;Jennifer L. Patnaik,&nbsp;Karen L. Christopher,&nbsp;Emily Auer,&nbsp;Cristos Ifantides","doi":"10.1016/j.clae.2026.102689","DOIUrl":"10.1016/j.clae.2026.102689","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine whether patient-reported symptoms or clinical signs more strongly influence dry eye disease (DED) treatment decisions and how decisions are made during sign-symptom discordance.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was distributed via listservs to practicing optometrists (ODs) and ophthalmologists (OPH) who treat DED. Respondents reported demographic and practice characteristics and selected factors influencing treatment initiation, management of sign–symptom discordance, and definitions of treatment success. Group comparisons were analyzed using Chi-square/Fisher's exact tests and <em>t</em>-tests, focusing on OD vs. OPH differences.</div></div><div><h3>Results</h3><div>208 clinicians participated (98 OPHs, 110 ODs). While most relied on a combination of signs and symptoms to initiate treatment, clinical severity heavily influenced decisions; clinicians were highly likely to initiate treatment for moderate–severe symptoms even when signs were minimal (OPH 79.8%, OD 70.5%) and to treat moderate–severe signs in asymptomatic patients (OPH 63.8%, OD 60.6%). However, symptoms were ultimately weighted more heavily for treatment initiation (OPH 61.7% vs. OD 49.0%). Only 1.1% of ophthalmologists and 5.2% of optometrists felt that signs and symptoms “frequently” correlate. When evaluating treatment success, both groups again prioritized symptom severity, selecting symptom improvement – either alone or over signs – as the primary indicator (OPH 78.7%, OD 66.6%). Ocular surface staining was rated the most influential clinical sign, followed by tear break-up time and eyelid abnormalities; tear osmolarity and MMP-9 were rated least influential.</div></div><div><h3>Conclusions</h3><div>Clinicians routinely navigate sign-symptom discordance by treating high clinical severity in either domain, though subjective symptoms ultimately exert a heavier influence on initial therapy choices and determinations of success. Decision-making patterns were similar across clinician types, underscoring the central role of patient-reported symptoms in real-world DED management.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102689"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148334016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Preliminary exploratory finding of anti-defocus (ADF) contact lenses on binocular vision” [Contact Lens Anterior Eye 49(3) (2026) 102657]","authors":"Jyh-Cheng Liou,&nbsp;Pin-Hsuan Chen,&nbsp;Hsiao-Ching Tung,&nbsp;Tze-Yu Tung,&nbsp;Chi-Wu Chang,&nbsp;Ching-Ying Cheng","doi":"10.1016/j.clae.2026.102690","DOIUrl":"10.1016/j.clae.2026.102690","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102690"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148413216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic contamination associated with contact lenses and related ophthalmic materials under real-world conditions","authors":"Joana Heinzelmann,&nbsp;Hardik Vaghasiya,&nbsp;Meet Dilipbhai Gadara,&nbsp;Susanne Gramsall,&nbsp;Arne Viestenz,&nbsp;Hoang Thinh Nguyen,&nbsp;Paul-Tiberiu Miclea","doi":"10.1016/j.clae.2026.102691","DOIUrl":"10.1016/j.clae.2026.102691","url":null,"abstract":"<div><h3>Purpose</h3><div>Commercial ophthalmic products including contact lenses are a source of microplastic pollution with increasing scientific interest due to prolonged and repeated contact with the ocular surface. But the polymer-based materials of associated containers for storing and cleaning of contact lenses may represent an underestimated source of microplastic exposure. This preliminary study investigated microparticle presence and composition, with particular focus on microplastics.</div></div><div><h3>Methods</h3><div>Samples of new and long-term used contact lenses, packaging materials, storage containers, and cleaning and storage solutions associated with vision-correction and bandage contact lenses were examined under routine real-world and laboratory conditions using standardized filtration with silicon membranes (1 μm pore size), high-resolution optical microscopy, and micro-Raman spectroscopy supported by automated spectral classification.</div></div><div><h3>Results</h3><div>Organic and anorganic microparticles were detected in all analyzed sample types, including laboratory water sources, clinical storage solutions as well as contact lens-associated materials and solutions. Packaging materials, storage containers, and cleaning solutions contributed substantially to the observed microplastic burden, exceeding background levels. Microplastics were detected in all sample types, with higher counts in long-term used lenses and their storage solutions. Polymer profiles suggested that most detected microplastics particles originated from external sources rather than from degradation of the lens material itself.</div></div><div><h3>Conclusion</h3><div>Contact lens associated materials represent relevant sources of microplastic exposure in ophthalmic practice. Repeated exposure during prolonged contact lens wear may facilitate cumulative microplastic accumulation at the ocular surface. Further systematic studies are required to clarify the biological relevance of this exposure and to inform future clinical and material design strategies.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102691"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148284575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a head strap on the function of an eyelid warming compress","authors":"Mou Saha,&nbsp;Ana Mustahsin,&nbsp;James S. Wolffsohn,&nbsp;Sònia Travé-Huarte","doi":"10.1016/j.clae.2026.102692","DOIUrl":"10.1016/j.clae.2026.102692","url":null,"abstract":"<div><h3>Purpose</h3><div>Warming eye masks, provide relief from symptoms of dry eye associated with meibomian gland disease along with other related eye conditions such as blepharitis, hordeolum and meibomian cysts. Certain eye mask designs use head straps to potentially improve mask retention on the face and heat transfer to the eyelids. Straps may increase pressure on the eye, the chance of tissue damage from direct heating, or pose a vision hazard for the user if they move around with the mask in place. This study investigated whether the presence of a strap clinically influences the performance of such eye masks.</div></div><div><h3>Methods</h3><div>The surface temperature decline of a Blepha EyeBag® eye mask (Théa Pharmaceuticals Limited,UK) placed on the facial area of a composite manikin head was measured with a thermographer following heating in a domestic microwave for 30, 45 and 60 s at a 800mw settings. Thermographic images were analyzed based on scale intensity using ImageJ software, and variations in facial temperature were plotted.</div></div><div><h3>Results</h3><div>Using a strap significantly (F = 40.451, <em>p</em> &lt; 0.001) decreased the temperature of the manikin upper eyelid by on average 1.4 ± 1.9 °C and lower eyelid by 2.5 ± 2.2 °C. The upper and lower eyelids heated to a similar temperature (on average 31.1 ± 5.1 °C vs 31.2 ± 5.4 °C, respectively; F = 0.064, <em>p</em> = 0.805), with temperate systematically increasing with Blepha EyeBag® heating time (F = 74.027, <em>p</em> &lt; 0.001). The temperature dropped with time following heating (F = 56.483, p &lt; 0.001) in a similar manner with and without the strap in place F = 1.949, <em>p</em> = 0.221).</div></div><div><h3>Conclusion</h3><div>The temperature transference to the eyelid surfaces was higher without the strap (on average by 1.9 ± 2.2 °C) possibly because the mask could conform to the contours of the face better when it wasn't pulled tight.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102692"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a model for the clinical prediction of contact lens discomfort","authors":"Laura Valencia-Nieto,&nbsp;Itziar Fernández,&nbsp;María J. González-García,&nbsp;Alberto López-Miguel","doi":"10.1016/j.clae.2026.102695","DOIUrl":"10.1016/j.clae.2026.102695","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate which ocular and contact lens (CL)-related dimensions, and their interactions, contribute most to CL discomfort (CLD), and to determine a set of clinical parameters for CLD assessment.</div></div><div><h3>Methods</h3><div>Cross-sectional study of consecutive CL wearers was performed. Variables were grouped into six dimensions (personal factors, CL characteristics, symptoms, cornea and conjunctiva, tear film, and lid margin and Meibomian glands). Within each dimension composite indices (0−100) were generated with a principal component analysis (mixed data). A structural equation model (SEM) was used to define the latent construct “CLD”, followed by unsupervised hierarchical agglomerative clustering. Cluster membership was subsequently predicted using a Least Absolute Shrinkage and Selection Operator (LASSO)-regularized logistic regression model with an 80/20 train–validation split. A simplified model intended for clinical use was developed.</div></div><div><h3>Results</h3><div>One hundred and fifty CL wearers (97 female; 34.4 ± 12.6 years) were included. SEM indicated a multidimensional structure in which the CL and symptom dimensions contributed most to latent CLD. Clustering yielded two distinct phenotypes that differed (<em>p</em> ≤ 0.043) in age, CL type and replacement schedule, daily wearing time, symptom severity, and several ocular surface parameters. A simplified predictor model (daily wearing time, CL replacement, Contact Lens Dry Eye Questionnaire-8, NIBUT, and tarsal hyperemia) predicted membership in the CLD phenotype with 85% accuracy and area under the curve of 0.956 in the validation set.</div></div><div><h3>Conclusions</h3><div>Modeling CLD as a latent, multidimensional construct integrating subjective and objective measures allows identification of clinically meaningful phenotypes and supports the development of an easy-to-use classifier with excellent discrimination.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 4","pages":"Article 102695"},"PeriodicalIF":4.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}