Contact Lens & Anterior Eye最新文献

{"title":"Validation and repeatability assessment of the Chinese version of the Ocular Surface Disease Index (OSDI), 5-item dry eye (DEQ-5), and contact lens dry eye questionnaire-8 (CLDEQ-8) questionnaires.","authors":"Biyue Guo, K Y Chan, Peter H Li, Jimmy S H Tse, Xulin Liao, Dylan Eng, Connie Chen, Ziqi Meng, Ruihua Wei, Allen Cheong, William Ngo, Thomas C Lam","doi":"10.1016/j.clae.2024.102353","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102353","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective study aimed to validate the translated Chinese versions of the Ocular Surface Disease Index (OSDI), 5-Item Dry Eye (DEQ-5), and Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) questionnaires and test their repeatability.</p><p><strong>Methods: </strong>From August 2022 to July 2023, online (qualtrics.com) English and Chinese versions of OSDI, DEQ-5, and CLDEQ-8 questionnaires were distributed to residents of Hong Kong, mainland China, Taiwan, and Singapore ≥ 18 years old who could understand both written Chinese and English. Subjects who were regular contact lens wearers (wear contact lenses > 5 days/week and > 8 h/day) were invited to complete the English and Chinese versions of the CLDEQ-8 questionnaire. Those who were not regular contact lens wearers were requested to complete the English and Chinese OSDI and DEQ-5 questionnaires. Subjects who completed the questionnaires were invited to participate for the second time three days later. Cronbach's alpha coefficient and intraclass correlation coefficient were used to test the internal consistency test-retest reliability of the translated questionnaires, respectively.</p><p><strong>Results: </strong>A total of 141 subjects completed the OSDI and DEQ-5 (50 (35 %) completed the second attempt) and 96 completed the CLDEQ-8 questionnaires (52 (54 %) completed the second time). All Chinese versions of the questionnaires showed adequate internal consistency (Cronbach's alpha coefficient ≥ 0.872) and high reliability. There were no significant differences between the two attempts for Chinese OSDI and DEQ-5, but a statistically (not clinically) significant difference for the Chinese CLDEQ-8. This indicates that the Chinese version is clinically comparable to the English version.</p><p><strong>Conclusion: </strong>The Chinese versions of OSDI, DEQ-5, and CLDEQ-8 questionnaires showed adequate internal consistency and high reliability. Despite not being identical in measured scores, the translated Chinese questionnaires could effectively provide information about dry eye conditions and be used as alternative tools for assessing and diagnosing dry eye in clinical practice.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102353"},"PeriodicalIF":4.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-assisted fitting method using corneal topography outcomes enhances success rate in orthokeratology lens fitting.","authors":"Xueyi Zhou, Li Zeng, Yang Shen, Zhe Zhang, Chongyang Wang, Bingjie Wang, Pauline Kang, Xingtao Zhou, Zhi Chen","doi":"10.1016/j.clae.2024.102350","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102350","url":null,"abstract":"<p><strong>Purpose: </strong>Based on ideal outcomes of corneal topography following orthokeratology (OK), an innovative machine learning algorithm for corneal refractive therapy (CRT) was developed to investigate the precision of artificial intelligence (AI)-assisted OK lens fitting.</p><p><strong>Methods: </strong>A total of 797 eyes that had been fitted with CRT lenses and demonstrated good lens centration with plus power ring intact in their topography were retrospectively included. A comprehensive AI model included spherical refraction, keratometry readings, eccentricity, corneal astigmatism, horizontal visible iris diameter, inferior-superior index, surface asymmetry index, surface regularity index and 8-mm chordal corneal height difference. A simplified AI model omitted the latter four parameters. Correlation and disparity in predicted lens parameters between the AI prediction and manufacturer's conventional lens fitting method were compared.</p><p><strong>Results: </strong>There was overall no significant difference between AI predicted parameters and the final ordered parameters (p > 0.05). The horizontal return zone depth (RZD1, p = 0.022) and vertical return zone depth (RZD2, p < 0.001) values suggested by the conventional method were significantly lower, while the horizontal landing zone angle (LZA1) was significantly larger (p = 0.002) than those of the final ordered lens. The AI predicted parameters were significantly correlated to those of the final ordered lens (p < 0.01), with the correlation coefficients of base curve radius (BCR), RZD1, RZD2, LZA1, vertical LZA (LZA2) and total lens diameter (TD) being 0.958, 0.708, 0.773, 0.697, 0.654 and 0.730, respectively, for the comprehensive AI model. The correlation coefficients were higher in RZD2, LZA1 and TD with the AI model as compared to conventional method.</p><p><strong>Conclusions: </strong>Compared with the conventional method, AI predicted lens parameters exhibit less disparity and improved accuracy, with a potential to facilitate more efficient and precise CRT OK lens fitting.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102350"},"PeriodicalIF":4.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised controlled trial on effects of topical insulin compared to artificial tears and normal saline on tear inflammatory mediator levels and clinical parameters in diabetics with dry eye disease.","authors":"A Atikah, M Suzana, W A H Wan Haslina, M D Norshamsiah, M Mushawiahti, K S S Birinder, S F Tang, M L C Bastion","doi":"10.1016/j.clae.2024.102346","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102346","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the short-term effects of topical insulin (TI) as compared to topical Systane Ultra^TM (Alcon, USA) as artificial tears (AT) and topical normal saline (NS) on tear inflammatory mediators; interleukin 1-alpha (IL-1a), interleukin 6 (IL-6) and matrix metalloproteinase 9 (MMP-9) and clinical dry eye parameters in diabetics with dry eye disease (DDED).</p><p><strong>Methods: </strong>In this randomized, multi-arm parallel single-centre trial, 73 diabetics with dry eye disease (30 female and 43 male) aged 18 to 50 years were recruited. They were randomly assigned to four weeks of treatment of either TI 0.5 unit/drop, AT or NS four times per day. Tear sample analysis and clinical parameters of dry eye (Ocular Surface Disease Index (OSDI), tear break-up time (TBUT), corneal Oxford score and Schirmers test) were evaluated at baseline and four weeks later. Objective clinical parameters for corneal Oxford score and tear break-up time were assessed by two masked investigators.</p><p><strong>Results: </strong>Significant reduction was seen in all inflammatory biomarkers (IL-1a, IL-6 and MMP-9) in all treatment groups at 4 weeks. In addition, inflammatory biomarkers demonstrated a significant reduction with TI (p < 0.001). Meanwhile, in AT and NS groups, reduction was also significant but less than TI group. Similarly, significant improvements were seen in all clinical parameters evaluated with all 3 treatments at 4 weeks; with TI group showing largest improvement as compared to AT and NS groups (p < 0.001). This is supported with the results as follows: mean difference -20.90 for OSDI as compared to -11.38 and -6.78 for AT and NS groups, respectively, 5.55 s for TBUT as compared to 3.00 s and 1.00 s for AT and NS group respectively, -2.40 for Oxford score as compared to -0.38 and -1.39 for AT and NS group respectively, and 5.20 mm for Schirmers test as compared to 3.00 mm and 1.00 mm for AT and NS group respectively.</p><p><strong>Conclusion: </strong>Treatment with TI resulted in the greatest reduction in inflammatory biomarkers and ocular eye parameters, as compared to AT and NS. TI was most effective in improving clinical parameters of DDED, although all topical therapies showed significant improvements, suggesting that use of TI may be beneficial in treating DDED.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102346"},"PeriodicalIF":4.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of ocular antibiotic-loaded soluble film inserts.","authors":"Alfredo Desiato, Affiong Iyire, Gurpreet Bhogal-Bhamra, Shehzad A Naroo, Raquel Gil-Cazorla","doi":"10.1016/j.clae.2024.102352","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102352","url":null,"abstract":"<p><p>Antibiotic eyedrops typically require frequent instillation due to the eye's defensive mechanisms limiting drugs from reaching target sites. This may risk patient non-adherence and treatment inefficacy. The aim of this study was to develop a biocompatible and fully soluble ocular film insert to enhance the delivery of levofloxacin, as well as the handling procedure for its administration; based on the anatomical dimensions and physiological conditions of the human eye. Inserts were prepared by solvent casting method, using HPMC, sodium alginate, gelatin, PEG 400, and levofloxacin solution, and characterised for various physicochemical properties (e.g., uniformity of weight and thickness, loss on dryness, swelling index, water uptake and surface pH). Mechanical properties were assessed and compared against a commercially available buccal film formulation. Uniformity of content and release profile of inserts were assessed by means of a validated analytical method. Antibacterial effectiveness was studied by adapted disc diffusion method on Staphylococcus aureus and Pseudomonas aeruginosa. The formulation including HPMC E15 (1250 mg), low viscosity sodium alginate (750 mg), type A gelatin (250 mg) and PEG 400 (2.5 mL) and 0.1% levofloxacin solution, resulted in high quality inserts, exhibiting uniformity of mass, thickness, and levofloxacin content, that comply with Pharmacopeial standards. Inserts were able to withstand unilinear and repeated mechanical stresses, suggesting suitability for manipulation linked to eye administration. The fully soluble levofloxacin-loaded inserts exhibited good physicochemical and mechanical characteristics, indicating good compatibility with ocular environment and administration procedure. Consistent levofloxacin content and biphasic release pattern showed immediate and sustained antimicrobial efficacy, consistently above the minimum inhibitory concentrations for the model species tested. This work also presents an experimental framework that can be adapted for designing and testing ocular drug delivery systems accounting for anatomical and physiological characteristics of the eye.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102352"},"PeriodicalIF":4.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital eye strain and clinical correlates in older adults.","authors":"Patrick A Moore, James S Wolffsohn, Amy L Sheppard","doi":"10.1016/j.clae.2024.102349","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102349","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the screen time habits, associated symptoms and clinical characteristics of an older population (60 years and older) drawn from primary care optometry.</p><p><strong>Methods: </strong>Consecutive patients aged 60 years and older, who used a digital device for at least 1 hour per day, attending for an eye examination at a primary care optometric practice in Dublin, Ireland, were invited to participate. The study gathered information regarding the participant's use of digital devices, the types of devices used and duration of use. Best corrected distance acuity and near vision adequacy for reading and device use was recorded.</p><p><strong>Results: </strong>401 responses were included in the analysis. Based on a Computer Vision Syndrome Questionnaire (CVS-Q) score ≥6, the occurrence of DES in this population was high at 51.6 % with females having a higher median score than males. The mean number of hours devices were used for was 4 hours. 71 % of participants reported symptoms of digital eye strain (DES) when using digital devices. Smart phones were the device type used most by participants but tablets were the device type used for the longest duration. Single vision spectacles were the most commonly used method of visual correction when using digital devices. Participants with better levels of acuity used devices for longer periods than those with poorer acuity.</p><p><strong>Conclusion: </strong>This study provides a valuable insight into the screen habits and likelihood of symptoms of DES in an older population and, is to date, the first of its kind. It shows that the prevalence of DES in older age adult device users is high, at 51.6 %, with a clear link between dry eye and symptoms of DES. Its results will enable optometrists to provide specific advice to this age group on how best to reduce symptoms of DES.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102349"},"PeriodicalIF":4.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear film stability in children: Age and sex associations explored through non-invasive tear break-up time.","authors":"Filipe Da Silva, João M M Linhares, Jorge Jorge, Madalena Lira","doi":"10.1016/j.clae.2024.102351","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102351","url":null,"abstract":"<p><strong>Purpose: </strong>The stability of the tear film is crucial for maintaining good ocular health. Its assessment provides valuable insights into paediatric eye conditions. This study investigates the stability of the tear film in children and its association with predictive factors such as age and sex, for a better understanding of tear film dynamics in a paediatric population.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in a semi-urban area in northern Portugal. Tear film stability was evaluated using non-invasive tear break-up time (NIBUT) measured with Tearscope Plus. The evaluation was conducted subjectively, with measurements obtained exclusively in the right eye. The mean of three consecutive measures of the NIBUT was considered in the statistical analysis.</p><p><strong>Results: </strong>A total of 2094 children (1072 females, 1022 males), with a mean age of 8.6 ± 1.3 years, were included. It was found a mean NIBUT of 14.8 ± 5.4 s (s), with no statistically significant difference between females (14.9 ± 5.4 s) and males (14.7 ± 5.4 s) (p = 0.407). Around 20 % of the children had a NIBUT < 10 s, and about 7 % had a NIBUT ≤ 5 s. A significant increase in NIBUT with age during the middle childhood stage (6 to 11 years old) was also found (p = 0.019), with NIBUT increasing from 14.1 ± 5.7 s in 6-year-olds to 16.3 ± 4.8 s in 11-year-olds (p = 0.006). However, when results were separated by the participants' sex, only the male group showed statistically significant differences (p = 0.021).</p><p><strong>Conclusions: </strong>A significant increase in NIBUT was found during the middle childhood stage, primarily driven by male participants. These findings underscore the importance of considering age and sex in assessing tear film stability in paediatric populations.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102351"},"PeriodicalIF":4.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diurnal variation of visual functions for driving with and without orthokeratology: A multicenter study.","authors":"Stefan Bandlitz, Jessica Gruhl, Gunther Oesker, Daniel Lachenmaier, Carsten Giepen, Barbara Reck, Oliver Hoppe, Wolf A Lagrèze, James S Wolffsohn","doi":"10.1016/j.clae.2024.102345","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102345","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate orthokeratology-related diurnal variations in visual acuity, contrast sensitivity, mesopic (twilight) vision, and glare sensitivity, and to verify compliance with requirements for driver licensing.</p><p><strong>Methods: </strong>In this prospective, multicenter, controlled study, fifty myopic (range, -1.00 to -4.50 D) and non-presbyopic glasses or soft contact lens wearers (age range, 16-39 years) were fitted with orthokeratology (OK) contact lenses. Before and after completion of OK lens fitting, measurements of visual acuity, contrast sensitivity, mesopic vision and glare sensitivity were performed at three times of the day, morning, afternoon and evening using a standardized binocular vision testing device (Oculus Binoptometer 4P). Monocular and binocular visual acuity were tested according to ISO 8596 and compared to requirements of cars and motorcycles drivers in different countries.</p><p><strong>Results: </strong>Compared to the prior correction, binocular visual acuity (logMAR) with orthokeratology was statistically significant better in the morning (0.04 ± 0.12; p < 0.05) and afternoon (0.04 ± 0.10; p < 0.05), while the difference was not statistically significant in the evening (p = 0.512). Furthermore, there was no statistically significant difference in contrast sensitivity in the morning (p = 0.813), afternoon (p = 0.742) or evening (p = 0.945). For both mesopic vision and glare sensitivity, there was no statistically significant difference between the contrast levels achieved with orthokeratology compared to the prior correction in the morning (p = 0.083; p = 1.000), afternoon (p = 0.054; p = 0.125) or evening (p = 0.195; p = 0.635). With orthokeratology, no statistically significant diurnal variation was found for binocular visual acuity, contrast sensitivity, mesopic vision or glare sensitivity (p > 0.05).</p><p><strong>Conclusions: </strong>These results provide evidence, that visual functions of OK lens wearers are stable throughout the day and comparable to the prior correction. Although the visual standards for driving are not uniform within countries, the requirements for visual acuity are met in all of the countries. Mesopic vision and glare sensitivity, which are suggested as other aspects to influence driving performance, also appear to be constant over the course of the day.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102345"},"PeriodicalIF":4.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in choroidal structures among children with low to moderate myopia under orthokeratology treatment.","authors":"Shengsong Xu, Yanbin Wang, Zhenbang Ruan, Shuhang Wang, Runzhuo Yin, Xianghua Tang, Mingxin Lu, Weiyin Chen, Zhouyue Li, Xiao Yang","doi":"10.1016/j.clae.2024.102342","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102342","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the longitudinal changes in choroidal features in myopic children with low to moderate myopia under orthokeratology (ortho-k) treatment.</p><p><strong>Methods: </strong>Children (n = 80) aged 8-12 years with spherical equivalent refraction of -1.00 to -6.00D were randomly assigned to the control (single vision spectacles) (n = 40) and ortho-k (n = 40) groups. OCT images were collected at the baseline, 1-, 6-, 12-, 18-, and 24-month visits. Choroidal structure parameters, including choroidal total area (TA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI) were calculated. Axial length (AL) was measured as the primary indicator for myopic progression. The analysis followed the intention-to-treat criteria.</p><p><strong>Results: </strong>Compared to the control, ortho-k significantly improved the choroidal structures in choroidal TA and LA at all follow-up points (all P < 0.05). Choroidal LA was the primary contributor to TA changes (85.8 %[control], 91.4 %[ortho-k]), with the most significant improvement within the first 6 months. While, the changes in SA and CVI over time were not significantly different between the two groups (all P > 0.05). Correlation matrices identified several noteworthy correlations between AL change and choroidal structure features. Further analysis showed a significant interaction effect between baseline choroidal LA and intervention type on subsequent AL change (P for interaction = 0.005), suggesting that ortho-k might be more effective in children with larger baseline choroidal LA.</p><p><strong>Conclusions: </strong>This 2-year prospective study demonstrated that ortho-k can improve the choroidal structures, primarily manifested in choroidal LA, although this positive effect diminishes over time. Myopic children with larger baseline choroidal LA might benefit more from ortho-k.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102342"},"PeriodicalIF":4.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International trends in prescribing multifocal and monovision soft contact lenses to correct presbyopia (2000-2023): An update.","authors":"Philip B Morgan, Nathan Efron, Craig A Woods, Deborah Jones, Lyndon Jones, Jason J Nichols","doi":"10.1016/j.clae.2024.102348","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102348","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous multifocal soft contact lenses have been introduced into clinical practice over the past half century. The purpose of this work is to update earlier surveys by describing international trends in multifocal and monovision soft lens fitting for presbyopia between 2000-2023, inclusive.</p><p><strong>Method: </strong>An annual contact lens prescribing survey was sent to eye care practitioners in up to 71 countries between 2000-2023. Data relating to 52,580 soft daily wear lens fits to presbyopes (those ≥45 years of age) undertaken in 20 countries returning reliable longitudinal data were analysed in respect of multifocal and monovision soft daily wear lens fits.</p><p><strong>Results: </strong>Overall, multifocal and monovision soft daily wear lens prescribing to presbyopes has more than doubled over the course of this survey, from 26.4 % of standard soft daily wear lens fits in 2000 to 61.1 % in 2023 (p < 0.0001). There were significant differences between countries in presbyopia soft daily wear lens prescribing (p < 0.0001). Of all soft daily wear fits to males, 45.1 % were multifocal and monovision soft lenses, compared with 52.7 % for females (p < 0.0001). When considered as the proportion of lenses fitted by age, multifocal soft lens fitting peaked between 50-65 years, followed by a precipitous drop until 85-90 years of age, and then an increase beyond 90 years of age. Analysis of 13,014 recent soft lens fits to presbyopes (2019-2023) revealed the following fitting proportions: multifocal lenses - 51 %; monovision - 10 %; and non-presbyopia fitting - 39 %.</p><p><strong>Conclusion: </strong>There has been a substantial increase in soft contact lens correction of presbyopia using multifocal and monovision corrections throughout the 24 years of this survey. A significant number of soft contact lens-wearing presbyopes are not receiving a presbyopia contact lens correction.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102348"},"PeriodicalIF":4.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level light therapy and intense pulse light therapy in meibomian gland dysfunction. A systematic review and meta-analysis.","authors":"Kai En Chan, Beth Shin Rei Lau, Blanche Xiao Hong Lim, Ruochen Du, Giuseppe Giannaccare, Louis Tong, Fiona Stapleton, Chris Hong Long Lim","doi":"10.1016/j.clae.2024.102344","DOIUrl":"https://doi.org/10.1016/j.clae.2024.102344","url":null,"abstract":"<p><strong>Background: </strong>Meibomian gland dysfunction (MGD) is a leading cause of dry eye disease, affecting over a third of the global population. This disease is associated with ocular discomfort, reduced visual quality, and quality of life. Novel treatments like Intense Pulse Light (IPL) therapy and Low-Level Light Therapy (LLLT) have been reported to be useful in refractory MGD treatment. However, no systematic review has explored the utility of combining these two therapies.</p><p><strong>Methods: </strong>Medline, Embase, and CENTRAL databases were searched for articles on LLLT + IPL therapy in MGD. A meta-analysis of single means was conducted to assess clinical endpoints.</p><p><strong>Results: </strong>Analysis of 12 studies showed that LLLT + IPL therapy in MGD patients led to a significant decrease in Ocular Surface Disease Index score (MD: -22.8, 95 %CI: -29.1 to -16.5, I² = 97.5 %, p < 0.001), and a significant increase in both Tear Break-up Time (MD: 2.2 s, 95 %CI: 0.9 s to 3.4 s, I² = 98.6 %, p < 0.001) and Schirmer test (MD: 1.5 mm, 95 %CI: 0.6 mm to 2.5 mm, I² = 0.0 %, p = 0.001) at ≤ 3 months post treatment. These improvements were sustained in a sensitivity analysis at endpoints ≥ 6 months post treatment. While the percentage of loss of meibomian gland area (n = 4, MD: -3.8 %, 95 %CI: -7.2 % to -0.4 %, I² = 40.0 %, p = 0.031) was reported to be significantly reduced, this was not found to be sustained at endpoints ≥ 6 months post treatment (n = 2, MD: 5.9 %, 95 %CI: 1.8 % to 10.0 %, I² = 0.0 %, p = 0.005) in two studies.</p><p><strong>Conclusions: </strong>This meta-analysis provides quantitative evidence supporting the clinical efficacy of LLLT + IPL therapy in MGD. Future research should evaluate its long-term safety and efficacy and compare it with alternative treatments.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102344"},"PeriodicalIF":4.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}