Contact Lens & Anterior Eye最新文献

{"title":"Comment on \"Effect of orthokeratology on ocular dominance in Chinese myopic children: A 1-year longitudinal study\".","authors":"Bing Sun, Kun Zheng","doi":"10.1016/j.clae.2026.102658","DOIUrl":"https://doi.org/10.1016/j.clae.2026.102658","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102658"},"PeriodicalIF":3.7,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of baseline characteristics on subjective improvement of dry eye after intense pulsed light therapy","authors":"Miriam Carrillo-Pulido ,&nbsp;Sonia Ortiz-Peregrina ,&nbsp;María Dolores López Pérez ,&nbsp;Antonio Cano-Ortiz ,&nbsp;Timoteo González-Cruces","doi":"10.1016/j.clae.2025.102514","DOIUrl":"10.1016/j.clae.2025.102514","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify baseline clinical signs and symptoms associated with response to intense pulsed light (IPL) combined with meibomian gland expression in dry eye disease (DED), and to develop machine learning (ML) models for individualized outcome prediction.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 100 eyes from 100 DED patients (aged 58.6 ± 13.4 years) treated with IPL and meibomian gland expression. Baseline parameters assessed with the Antares system included meibomian gland loss (MGL), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), conjunctival hyperemia, and Ocular Surface Disease Index (OSDI). Patients were stratified by change in OSDI after treatment (ΔOSDI): Class 1 (no improvement), Class 2 (mild improvement), and Class 3 (clear improvement). Several ML models were trained to predict ΔOSDI from baseline parameters.</div></div><div><h3>Results</h3><div>IPL significantly improved both symptoms and signs. OSDI decreased from 44.65 ± 18.3 to 28.47 ± 19.3 (p &lt; 0.001), NIBUT increased from 4.5 ± 3.2 to 7.5 ± 6.5 s (p &lt; 0.001), and TMH and conjunctival hyperemia also improved (p &lt; 0.001), while MGL and BCVA remained stable. Greater improvement was observed in patients with higher baseline OSDI (p = 0.001). The XGBoost algorithm achieved the highest predictive performance (AUC-ROC = 0.77), with OSDI and NIBUT as the strongest predictors based on SHAP analysis.</div></div><div><h3>Conclusions</h3><div>IPL combined with meibomian gland expression improves symptoms and signs in DED, particularly in patients with more severe baseline symptoms. Baseline OSDI and NIBUT were the strongest predictors of response. ML models demonstrated moderate accuracy, supporting their potential role in personalized DED treatment strategies.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102514"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ambient illuminance and mobile phone screen brightness on tear film stability, visual fatigue, and blink patterns during reading","authors":"Meng Lin ,&nbsp;Xinkai Zheng ,&nbsp;Charong He ,&nbsp;Meng Li ,&nbsp;Fan Lu ,&nbsp;Liang Hu","doi":"10.1016/j.clae.2025.102515","DOIUrl":"10.1016/j.clae.2025.102515","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate the impacts of different ambient illuminance and screen brightness conditions on tear film stability, visual fatigue, and blink patterns during mobile phone reading.</div></div><div><h3>Methods</h3><div>This prospective study involved 30 young subjects who completed 4 experiments based on ambient illuminance and screen brightness: Group 1: bright room, bright screen; Group 2: dark room, dark screen; Group 3: bright room, dark screen; Group 4: dark room, bright screen. Participants completed a 30-minute mobile phone reading task in each experiment. Tear film stability indicators, including fluorescein tear break-up time (FTBUT), noninvasive tear breakup time, tear meniscus height, and lipid layer thickness, were measured before and after reading. During reading, an infrared camera recorded blink-related parameters. Subjective questionnaires assessed comfort and visual fatigue.</div></div><div><h3>Results</h3><div>After the reading task, the FTBUT of each group significantly decreased (all P &lt; 0.05). Notably, all tear film stability indicators significantly changed in Group 4. The incomplete blink rate in all the groups tended to increase over time (all P &lt; 0.05). Among the four groups, Group 4 had a significantly greater incomplete blink rate and partial blink ratio (P &lt; 0.05), along with a greater subjective fatigue score, than did Group 1 (P &lt; 0.01). The frequency of incomplete blinks (r = 0.29, P = 0.03) was positively correlated with the visual fatigue score.</div></div><div><h3>Conclusions</h3><div>Reading in a dark environment with a bright screen led to the most significant instability of the tear film, visual fatigue, and changes in blink patterns. Therefore, it is advisable to avoid reading under such conditions.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102515"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of deep learning models for anterior segment OCT image segmentation during scleral lens wear","authors":"Yoel Garcia Marin ,&nbsp;David Alonso-Caneiro ,&nbsp;Michael J Collins ,&nbsp;Stephen J Vincent","doi":"10.1016/j.clae.2025.102484","DOIUrl":"10.1016/j.clae.2025.102484","url":null,"abstract":"<div><h3>Purpose</h3><div>The accurate segmentation of corneal and contact lens boundaries in anterior segment optical coherence tomography (AS-OCT) images provides essential clinical information. The purpose of this study was to evaluate the performance of sixteen different deep learning (DL) models developed to segment AS-OCT images obtained during scleral lens wear.</div></div><div><h3>Methods</h3><div>AS-OCT images were obtained from 15 participants with normal corneas after 0 and 480 min of scleral lens wear. An experienced observer manually annotated the boundaries of interest in each image (considered the ground truth) including the anterior and posterior scleral lens surfaces, the anterior corneal epithelial surface, the anterior stromal interface, and the endothelium. Four different architectures were adapted for semantic segmentation (U-Net, U-Net++, FPN, and MA-Net) each of which was tested with five different encoders (EfficientNet-B4, DenseNet201, VGG19, ResNet34, and Xception). Following training, the segmentation performance of each model was evaluated using the Dice coefficient (measurement of the area overlap) and the mean absolute boundary error.</div></div><div><h3>Results</h3><div>All DL models displayed a high level of performance for classification and segmentation of the scleral contact lens and fluid reservoir (with Dice coefficients typically &gt; 99 % and mean absolute error values of &lt; 1 pixel). Misclassification issues arose for some models, likely linked to the lower reflectivity and homogeneity of the interface between Bowman’s layer and the corneal stroma. Overall, only minor differences were observed between models, with the U-Net++/VGG19 combination displaying the best performance with an overall Dice score of 99.26 % and per class Dice scores ranging from 99.11 to 99.77 %.</div></div><div><h3>Conclusion</h3><div>The U-Net++/VGG19 DL model displayed the best performance for AS-OCT image segmentation during scleral lens wear based on the overall Dice coefficient. Further assessment of DL models involving the segmentation of eyes with corneal disease and altered tissue morphology during scleral lens wear is warranted.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102484"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the quality-of-life impacts of ocular surface disease","authors":"Pawan Baral ,&nbsp;Sheela Evangeline Kumaran ,&nbsp;Fiona Stapleton ,&nbsp;Jwu Jin Khong ,&nbsp;Nicole Carnt ,&nbsp;James S. Wolffsohn ,&nbsp;Konrad Pesudovs","doi":"10.1016/j.clae.2025.102482","DOIUrl":"10.1016/j.clae.2025.102482","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to explore the lived experience of adults with different types of ocular surface disease (OSD) to understand their quality of life (QoL) impacts.</div></div><div><h3>Methods</h3><div>Lived experiences of participants diagnosed with aqueous deficient dry eye disease (DED), meibomian gland dysfunction (MGD), anterior blepharitis, neuropathic corneal pain (NCP), ocular surface involvement of autoimmune disease and contact lens discomfort (CLD) were explored using in-depth, semi-structured interviews. Participants were recruited from specialized dry eye clinics in Australia, United Kingdom, as well as online support groups. Thematic analysis of interviews was performed to identify key QoL themes.</div></div><div><h3>Results</h3><div>Sixty-two participants participated in an in-depth interview (median age: 46 years, range 22–78). There were 16 male participants (median age: 38.5 years; range: 23–74) and 46 female participants (median age: 50 years; range 22–78). The distribution of participants by condition as follows: DED − 9, MGD − 12, anterior blepharitis – 8, NCP − 8, ocular surface involvement of autoimmune disease – 14, and CLD – 11. Thirteen major QoL themes emerged. The most significant impact observed was on the emotional wellbeing with participants describing feelings of annoyance, depression, frustration, reduced self-confidence, worry, and anxiety related to their condition. Many expressed concerns about the chronic nature of OSDs, characterised by persistent symptoms and lifelong treatment. Economic impact extended beyond direct medical expenses, affecting employment, and productivity. Participants also described difficulties with daily activities, driving and mobility. Coping strategies included adjustments to their daily routine and environment.</div></div><div><h3>Conclusion</h3><div>OSDs significantly impact multiple aspects of an individual’s life. These findings lay the foundation for developing a comprehensive and technologically advanced patient reported outcome measure (PROM) tailored to individuals with OSDs. Addressing these QoL concerns through targeted interventions and policy updates will be crucial in enhancing patient care and optimizing disease management.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102482"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144795962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal gland Ga-68 PSMA-11 PET/CT radiomic profile: a potential novel imaging biomarker in dry eye disease","authors":"Nihat Köylüce ,&nbsp;Mahmut Erkam Arslan","doi":"10.1016/j.clae.2025.102600","DOIUrl":"10.1016/j.clae.2025.102600","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to investigate the relationship between texture analysis parameters of lacrimal gland activity and dry eye disease (DED) in participants undergoing Gallium-68 labelled Prostate-Specific Membrane Antigen ligand Positron Emission Tomography / Computed Tomography ([68 Ga]Ga-PSMA-11 PET/CT) imaging for prostate cancer (PCa).</div></div><div><h3>Methods</h3><div>A prospective cohort of 56 male patients who underwent [68 Ga]Ga-PSMA-11 PET/CT for PCa at the Department of Nuclear Medicine, Kayseri City Hospital (October 2024–June 2025) were included. Lacrimal gland regions of interest were delineated using LIFEx software with a 40 % maximum standard uptake value (SUVmax) threshold. Texture features (morphological, intensity-based, intensity-histogram) were extracted. An ophthalmological evaluation focused on dry-eye parameters was conducted, which included the Ocular Surface Disease Index (OSDI) scoring, in addition to Schirmer and tear break-up time (TBUT) test. Statistical analyses included Spearman correlation, univariate binary logistic regression, and ROC analysis; p &lt; 0.05 was considered significant.</div></div><div><h3>Results</h3><div>Thirty-two participants (57 %) met the criteria for DED. Several intensity-based and histogram parameters were significantly lower in DED participants. SUVmax (cut-off 7.65) demonstrated limited but statistically significant diagnostic potential (AUC = 0.669, p = 0.031; sensitivity 75 %, specificity 50 %). Higher intensity measures correlated with higher TBUT and Schirmer scores and lower OSDI scores.</div></div><div><h3>Conclusions</h3><div>Texture analysis of lacrimal gland activity on [68 Ga]Ga-PSMA-11 PET/CT provides potential, non-invasive quantitative biomarkers for DED. Intensity-based metrics (SUVmean, SUVmax) may reflect functional impairment of the lacrimal gland. Further multicenter validation is warranted.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102600"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145839802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of keratoconus following allergic conjunctivitis: a multicenter retrospective cohort study using a U.S. healthcare network database","authors":"Nathan Lishinsky-Fischer ,&nbsp;Nir Erdinest ,&nbsp;Ortal Buhbut ,&nbsp;Zvi Gur","doi":"10.1016/j.clae.2025.102569","DOIUrl":"10.1016/j.clae.2025.102569","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the risk of keratoconus and related corneal complications in patients with allergic conjunctivitis, using a large, multicenter real-world dataset.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted utilizing the TriNetX US Collaborative Network. Patients aged 5–25 years with allergic conjunctivitis were matched to patients with non-allergic conjunctivitis using 1:1 propensity score matching. The primary outcome was incident keratoconus. Secondary outcomes included corneal topography, advanced corneal diagnostic procedures (e.g., pachymetry and scanning computerized ophthalmic imaging), keratoconus-specific contact lens fitting, corneal cross-linking, keratoplasty, recurrent corneal erosion, and acute corneal hydrops. Survival analysis was performed using Kaplan-Meier curves and Cox proportional hazards models.</div></div><div><h3>Results</h3><div>After matching, 174,443 patients were included in each cohort. Allergic conjunctivitis was associated with a significantly increased risk of keratoconus (HR 1.6; 95 % CI, 1.18–2.18; p = 0.0024), with 118 patients developing the condition versus 62 in the control group. Corneal erosion was significantly associated with allergic conjunctivitis as well with HR of 1.87 (95 % CI 1.05–3.34; p = 0.0305). Corneal topography and advanced corneal diagnostic procedures were also more frequent in the allergic group with HRs of 1.94 (95 % CI 1.58–2.38; p &lt; 0.0001) and 2.05 (95 % CI 1.74–2.4; p &lt; 0.0001), respectively.</div></div><div><h3>Conclusions</h3><div>Allergic conjunctivitis is associated with an elevated risk of keratoconus and an increased need for corneal diagnostic evaluation in children and young adults. These findings support the implementation of enhanced screening and proactive allergy management in this population.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102569"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145551720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dehydration kinetics of soft contact lenses: The hidden impact of early wear","authors":"Silvia Tavazzi ,&nbsp;Anna Galli ,&nbsp;Francesco Maspero ,&nbsp;Giulia Carlotta Rizzo ,&nbsp;Fabrizio Zeri ,&nbsp;Erika Ponzini","doi":"10.1016/j.clae.2025.102512","DOIUrl":"10.1016/j.clae.2025.102512","url":null,"abstract":"<div><div>In contact lens (CL) wear, maintaining adequate CL hydration is essential to prevent ocular dryness and associated discomfort. In this context, dehydration of worn Etafilcon A and Kalifilcon A CLs hydrated by natural tears was monitored using an in-vitro gravimetric method. A kinetic model was applied to derive the water kinetics coefficient, which emerged as a reliable indicator of the on-eye hydration state and water diffusion mechanisms. A significant reduction in water content and a tendency from a polymer-hindered water diffusion toward free diffusion were observed after just five minutes of wear, suggesting a rapid initial adaptation to the ocular environment that alters the material resistance to water evaporation. After two hours of wear, a similar effect was evident in approximately half of the samples investigated, indicating that a new hydration equilibrium may eventually be reached over time.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102512"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vision-related quality of life in highly myopic children undergoing orthokeratology treatment","authors":"Yajing Yang ,&nbsp;Stephen J. Vincent ,&nbsp;Sin W. Cheung ,&nbsp;Pauline Cho ,&nbsp;Henry H.L. Chan","doi":"10.1016/j.clae.2025.102580","DOIUrl":"10.1016/j.clae.2025.102580","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;To compare the vision-related quality of life (VRQoL) of highly myopic children before and after one-year orthokeratology (&lt;em&gt;ortho&lt;/em&gt;-k) treatment, and between full and partial correction &lt;em&gt;ortho&lt;/em&gt;-k groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Chinese children aged 7 to 13 years, with myopia no less than −5.00 D and astigmatism no more than −2.00 D, were fitted with either a conventional &lt;em&gt;ortho&lt;/em&gt;-k lens design targeted for −4.00 D or a dual RC design targeted for full correction. Participants were required to wear spectacles during the day if their residual spherical refraction was no less than −1.25 D or monocular unaided visual acuity was worse than 0.18 logMAR. VRQoL was evaluated before and after one-year &lt;em&gt;ortho&lt;/em&gt;-k treatment using the traditional Chinese Paediatric Refractive Error Profile (PREP) questionnaire along with four additional questions regarding symptoms and their frequency after treatment. Participants were retrospectively classified into full and partial correction groups, based on their spectacle dependence at the one-year follow-up visit. The overall PREP score, calculated from the mean of 10 subscales, and the 10 subscales themselves, were compared pre- and post-&lt;em&gt;ortho&lt;/em&gt;-k treatment, and between the full and partial correction groups.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Thirty-eight participants (full correction: 17, partial correction: 21) completed the study. At baseline, the partial correction group exhibited significantly greater spherical refraction and SER than the full correction group (p &lt; 0.001), while unaided monocular visual acuity was comparable between the groups (p = 0.41). At the one-year follow-up, the full correction group had significantly lower residual spherical refraction and SER, and better unaided monocular visual acuity than the partial correction group (p &lt; 0.001). No significant Group by Visit interactions were observed for any PREP subscales (p ≥ 0.13), indicating similar patterns of change over time in both groups. A significant improvement in the “Activities” subscale was found with &lt;em&gt;ortho&lt;/em&gt;-k treatment compared to spectacle wear in both groups (main effect of Visit, p = 0.001). For the “Handling” subscale, when averaging across both time points, the full correction group reported consistently higher scores than the partial correction group (spectacle wear: 83 ± 3 vs 78 ± 3) and the one-year follow-up (&lt;em&gt;ortho&lt;/em&gt;-k wear: 85 ± 2 vs 75 ± 3) (main effect of Group, p = 0.03). Although an improving trend in the “Appearance” subscale was noted in the full correction group following &lt;em&gt;ortho&lt;/em&gt;-k (57 ± 6 vs 72 ± 4), compared to stable scores in the partial correction group (62 ± 5 vs 63 ± 3), this difference was not significant (Group by Visit interaction, p = 0.13). Regarding symptoms experienced during nighttime &lt;em&gt;ortho&lt;/em&gt;-k lens wear, the most reported symptoms (∼18%) were “ocular discomfort” and “itchy/burning/dryness”, wit","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102580"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense pulsed light therapy to improve signs and symptoms of contact lens discomfort","authors":"Srikanth Dumpati,&nbsp;Fatima Iqbal,&nbsp;Ajay Kumar Vijay,&nbsp;Jacqueline Tan,&nbsp;Mukesh Kumar,&nbsp;Mark Willcox","doi":"10.1016/j.clae.2025.102486","DOIUrl":"10.1016/j.clae.2025.102486","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the effects of Intense Pulsed Light (IPL) therapy on signs and symptoms of Contact Lens Discomfort (CLD) in symptomatic contact lens (CL) wearers.</div></div><div><h3>Methods</h3><div>A prospective, randomised, double masked study was conducted on 36 eyes of 18 CL wearers (IPL: n = 20; sham: n = 16) with a Contact Lens Dry Eye Questionnaire (CLDEQ-8) score ≥ 12. Participants received two IPL/sham treatments at three weeks intervals as per randomization. The sham group underwent simulated light exposure using a torch while the IPL device remained inactive. Meibomian gland expression was performed for both groups after each treatment. Symptom and clinical assessments included CLDEQ-8 questionnaire, non-invasive tear breakup time (NITBUT), tear film lipid layer thickness (TFLLT), tear meniscus height (TMH), tear volume, meibomian gland secretion score (MGSS), meiboscore (upper/lower eye lids), MG capping, pouting, foam, telangiectasia, hyperaemia (bulbar, limbal, &amp; palpebral), palpebral roughness, corneal staining, and lid-parallel conjunctival folds (LIPCOF). Assessments were evaluated prior to treatment at baseline (D-0), and then at day 21(D-21), D-42, and D-90.</div></div><div><h3>Results</h3><div>The IPL group showed a significant reduction in CLDEQ-8 score from 18.1 ± 1.9 at D-0 to 10.7 ± 1.1 at D-42 (p = 0.01), and improved meibomian gland secretion score (MGSS) at D-21 (p = 0.02) and D-42 (p &lt; 0.01), MG capping, and pouting remained improved at D-90 (p &lt; 0.01). MG foam, telangiectasia, bulbar hyperaemia and corneal staining improved significantly at D-42 (p &lt; 0.01), but most changes diminished by D-90. The sham group showed no significant changes. No differences were observed in tear film parameters at any time point.</div></div><div><h3>Conclusion</h3><div>IPL therapy, effectively reduced symptoms of CLD and improved meibomian gland function, though effect diminished within 69 days after the final treatment, underscoring the need for optimized treatment protocols.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"49 1","pages":"Article 102486"},"PeriodicalIF":3.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}