Contact Lens & Anterior Eye最新文献

{"title":"Artificial intelligence versus conventional methods for RGP lens fitting in keratoconus","authors":"Jérémy Abadou ,&nbsp;Simon Dahan ,&nbsp;Juliette Knoeri ,&nbsp;Loic Leveziel ,&nbsp;Nacim Bouheraoua ,&nbsp;Vincent M Borderie","doi":"10.1016/j.clae.2024.102321","DOIUrl":"10.1016/j.clae.2024.102321","url":null,"abstract":"<div><h3>Background</h3><div>To compare the efficiency of three artificial intelligence (AI) frameworks (Standard Machine Learning (ML), Multi-Layer Perceptron (MLP) and Convolution Neural Networks (CNN)) with a reference method (Mean radius of curvature (K)) to predict the posterior radius of curvature of the best-fitted rigid contact lens (RCBFL) in keratoconus eyes.</div></div><div><h3>Methods</h3><div>This retrospective study included 197 keratoconus eyes of 135 patients fitted with Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and September 2022. Two types of topographic data (indices and reconstructed maps from raw data) were used for AI analysis. Three distinct approaches were utilized for leveraging AI: Standard ML methods and MLPs based on topographic indices and CNNs based on topographic maps (i.e., corneal thickness, sagittal, and tangential maps). Seventeen AI framework’s accuracies were compared with the r² determination coefficient of linear regression between predicted and best-fitted radii. Framework accuracies were compared with the Fisher z-transformation of Pearson correlation coefficients.</div></div><div><h3>Results</h3><div>In multiple linear regression, only three topographic indices (i.e., 3- &amp; 5-mm mean K and Kmax) were significantly associated with RCBFL (p ≤ 0.0001). Compared with the reference method (mean-K; r² = 0.36), a significantly better RCBFL prediction was achieved with Random Forest using the three topographic indices, MLP using all indices, ResNet18 CNN using anterior topographic maps and CNNs using combined parameters (0.69 ≤ r² ≤ 0.80; p &lt; 0.05). The best accuracy was obtained with the EfficientNetB0 CNN trained with three maps (r² = 0.80).</div></div><div><h3>Conclusions</h3><div>Artificial intelligence methods, particularly CNNs, with corneal topography data of MS39® topographer, have demonstrated superiority over conventional approaches in predicting the posterior curvature radius of Rose K2® rigid contact lenses in patients with keratoconus.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102321"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment","authors":"Mengqi Liu ,&nbsp;Jing Huang ,&nbsp;Zhu Xie ,&nbsp;Yuanyuan Wang ,&nbsp;Pengqi Wang ,&nbsp;Ruijing Xia ,&nbsp;Xinting Liu ,&nbsp;Binbin Su ,&nbsp;Jia Qu ,&nbsp;Xiangtian Zhou ,&nbsp;Xinjie Mao ,&nbsp;Hao Wu","doi":"10.1016/j.clae.2024.102314","DOIUrl":"10.1016/j.clae.2024.102314","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the dynamic changes of choroidal vasculature and its association in mediating ocular elongation over 1 year of orthokeratology (<em>ortho</em>-k) treatment.</div></div><div><h3>Methods</h3><div>This observational study included 8–14 year old myopic children who were willing to receive <em>ortho</em>-k treatment or wear single vision spectacle lenses (SVL). Axial length (AL) and choroidal characteristics, including submacular luminal area (LA), stromal area (SA), total choroidal area (TCA), choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT) and choriocapillaris flow deficits (CcFD) from OCT/OCTA images, were evaluated at baseline, 3, 6 and 12 months.</div></div><div><h3>Results</h3><div>After 1 year, AL elongation was significantly less in 25 children treated with <em>ortho</em>-k than in 29 children wearing SVL (0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P&lt;0.01). In the <em>ortho</em>-k group, LA, SA, TCA and SFCT were significantly increased by 0.033 ± 0.059 mm², 0.024 ± 0.035 mm², 0.058 ± 0.087 mm², 8.9 ± 17.4 μm, respectively, at 3 months (all P&lt;0.05). These parameters returned to near baseline levels over the following 9 months. Meanwhile, CcFD decreased by 0.83 ± 1.09 % over 12 months, but CVI remained steady during this period. No significant changes in these choroidal parameters (except for CcFD, decreased by −0.56 ± 1.23 %) were observed in the SVL group over 12 months. Increases in SFCT, LA, SA and TCA over 12 months were significantly greater in the <em>ortho</em>-k group than in the SVL group. Mediation analyses showed that 44.8 % of effect on inhibiting AL elongation through <em>ortho</em>-k was mediated via TCA (in particular LA).</div></div><div><h3>Conclusions</h3><div>The decelerated ocular elongation during <em>ortho</em>-k treatment is accompanied by increases in content of choroidal vascular lumen and stromal component. Dynamic changes of choroidal vasculature provide a possible mechanism underlying myopia control efficacy via <em>ortho</em>-k.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102314"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective impressions with myopia control contact lenses versus single vision lenses: A systematic review and meta-analysis","authors":"Xiaona Ping,&nbsp;Nayuta Yoshioka,&nbsp;Juno Kim,&nbsp;Padmaja Sankaridurg","doi":"10.1016/j.clae.2024.102303","DOIUrl":"10.1016/j.clae.2024.102303","url":null,"abstract":"<div><h3>Purpose</h3><div>To gain insight into patients’ visual experiences and satisfaction when using different forms of myopia control lenses.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, Embase, Scopus and Web of Science databases were searched for articles assessing subjective visual quality with myopia control lenses compared with single-vision lenses (SVLs) up to July 10, 2023. Eight-hundred-and-three articles were retrieved, reviewed and any questionnaire items on subjective impressions of lens wear were meta-analysed. Subgroup analyses were based on the magnitude of defocus (add power) of multifocal soft contact lenses (MFSCLs) and age groups. A random-effects model was employed for meta-analysis, and I² statistic used to assess the statistical heterogeneity.</div></div><div><h3>Results</h3><div>Nineteen articles fit the criteria, but only six articles involving MFSCLs had relevant data. MFSCLs were associated with lower subjective ratings of vision at different distances compared to SVLs (p &lt; 0.001), but the differences were less than one unit. MFSCLs also yielded lower ratings when moving or walking and/or climbing stairs at −0.38 (−0.69 to −0.07, p = 0.02; I² = 85 %, p &lt; 0.001) and for subjective comfort (difference of −0.23, −0.41 to −0.05, p = 0.01; I² = 63 %, p &lt; 0.001). Subjective ratings for playing sports were not different between groups. Experience with MFSCLs was rated lower by young adults compared to children for all variables. In both children and young adults, ratings were lower with higher add compared to lower add MFSCLs.</div></div><div><h3>Conclusion</h3><div>Although subjective ratings for vision and comfort were lower with MFSCLs compared to SVLs, the difference was mostly less than one unit. Importantly, young adults rated their visual experience lower compared to children.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102303"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value","authors":"Liuyun Chong ,&nbsp;Ziwen Sun ,&nbsp;Yanling Wang ,&nbsp;Tianpu Gu ,&nbsp;Weiping Lin ,&nbsp;Bei Du ,&nbsp;Ruihua Wei","doi":"10.1016/j.clae.2024.102334","DOIUrl":"10.1016/j.clae.2024.102334","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the safety and efficacy of the trial lens-fitting and software-fitting in orthokeratology for myopia control in children with high corneal eccentric value.</div></div><div><h3>Methods</h3><div>Myopic children with high corneal eccentric value (≥0.65) receiving treatment for orthokeratology from July 2020 to January 2022 were included in this retrospective study. Only the right eyes were included. The participants were allocated into two groups: the trial lens-fitting group (n = 41) and the software-fitting group (n = 48). The uncorrected visual acuity (UCVA), corneal topography, and ocular health (Efron grading scales) were recorded at baseline, one week, two weeks, one, three, six, and 12 months after<!--> <!-->the initiation of lens wear. The axial length and endothelial cell density were assessed at baseline and after 12 months of lens wear.</div></div><div><h3>Results</h3><div>The success rate of the first fit in the software-fitting group and trial lens-fitting group reached 98 % and 95 %, respectively. The difference in UCVA and corneal staining were statistically insignificant between the two groups during all visits. The software-fitting group exhibited a smaller treatment zone size (radius 1.69 ± 0.21 mm vs 1.81 ± 0.16 mm, p = 0.004; area 9.13 ± 2.15 mm² vs 10.36 ± 1.82 mm², p = 0.005) and less decentration (0.58 ± 0.31 mm vs 0.74 ± 0.39 mm, p = 0.036) compared with the trial lens-fitting group. There were no significant differences in axial elongation (0.15 ± 0.12 mm vs. 0.17 ± 0.14 mm, p = 0.534) or changes in endothelial cell density (−36.63 ± 99.37/mm² vs − 13.71 ± 87.72/mm², p = 0.256) between the software-fitting group and the trial lens-fitting group at one-year follow-up visit.</div></div><div><h3>Conclusion</h3><div>Both fitting methods were effective and safe. However, the software-fitting method resulted in a smaller treatment zone size and less decentration.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102334"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of midday removal and re-application of a scleral lens on fluid reservoir thickness, pre-lens tear film quality and visual acuity","authors":"Rute J. Macedo-de-Araújo ,&nbsp;Ana Amorim-de-Sousa ,&nbsp;José M. González-Méijome","doi":"10.1016/j.clae.2024.102250","DOIUrl":"10.1016/j.clae.2024.102250","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate whether the midday removal and re-application of scleral lenses<span> (SL) influences fluid reservoir (FR) thickness, pre-lens tear film quality and visual acuity.</span></div></div><div><h3>Methods</h3><div>Two clinical experiments were conducted. A total of 49 keratoconic eyes were evaluated for Part1<!--> <span>(tear film and visual acuity analysis) and 12 keratoconic eyes for Part2 (FR thickness analysis). All subjects were wearing 16.4 mm SL for more than 12-months. Tear Film Surface Quality (TFSQ) was evaluated with Medmont E300 at more than 120 min of SL wear, 10 min after SL removal (pre-corneal TFSQ) and 5 min after re-apply the same SL. High and Low Contrast Visual Acuity (HCVA and LCVA) were also assessed with the SL on eye (before and after re-application). For Part2, Anterior OCT (MOptim MOcean4000, China) measurements were taken with and without the SL (at the same time points of Part1) and three outcomes were evaluated: FR thickness, SL thickness (control measurement) and corneal thickness.</span></div></div><div><h3>Results</h3><div>Removing and re-applying a SL had a statistically significant positive impact on TFSQ, with an improvement from 0.26 ± 011 to 0.16 ± 0.08 (p = 0.001). This was accompanied by a statistically significant improvement in LogMAR HCVA (from 0.10 ± 0.09 to 0.08 ± 0.08, p &lt; 0.001) and LCVA (from 0.39 ± 0.13 to 0.36 ± 0.13, p &lt; 0.001). Regarding Part2 of the study, a statistically significant increase in FR thickness was observed after SL re-application (from 223.64 ± 48.08 µm to 267.81 ± 80.03 µm, p = 0.007). No changes in corneal thickness were observed.</div></div><div><h3>Conclusions</h3><div> <!-->Midday removal and re-application of a scleral lens positively impacted pre-lens tear film surface quality, although the observed improvement in visual acuity does not constitute a clinically significant change. Clinicians should consider that removing and reapplying a scleral lens may result in an overestimation of the fluid reservoir thickness, which could affect clinical assessments and treatment decisions.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102250"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Add-on effect of using 0.05% atropine in fast progressors of orthokeratology: A preliminary retrospective study","authors":"Longbo Wen ,&nbsp;Hong Liu ,&nbsp;Qinglin Xu ,&nbsp;Wei Pan ,&nbsp;Zhenghua Lin ,&nbsp;Zhigang Xiao ,&nbsp;Zhikuan Yang ,&nbsp;Weizhong Lan ,&nbsp;Zhao Chen","doi":"10.1016/j.clae.2024.102282","DOIUrl":"10.1016/j.clae.2024.102282","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the potential benefit of combining orthokeratology (OK) lenses with 0.05% atropine ophthalmic solution on the efficacy of myopia control in the fast progressors of OK.</div></div><div><h3>Methods</h3><div>Average axial length (AL) elongation of both eyes in 70 participants using OK lenses alone or OK lenses combined with 0.05 % atropine ophthalmic solution was retrospectively reviewed. During the observation period (phase 1), all participants exhibited an AL elongation that exceeded 0.15 mm over a 6-month period or 0.3 mm over a 12-month period. Subsequently, the participants were divided into two groups: one group received nightly 0.05 % atropine ophthalmic solution in addition to OK lenses for another 1 year (OKA), while the other group continued using OK lenses alone (phase 2). The changes in AL elongation over time and the differences in AL elongation between the two groups were then compared.</div></div><div><h3>Results</h3><div>The baseline and phase 1 demographics and characteristics of the participants was similar between the two groups (all p &gt; 0.05). when considering a one-year timeframe, the OKA group displayed a significantly less AL elongation compared to the OK group (0.14 ± 0.13 mm vs 0.27 ± 0.12 mm, p &lt; 0.001). Within the OKA group, the AL elongation in the second half of the year was significantly faster than in the first half (0.12 ± 0.11 mm vs 0.02 ± 0.14 mm, p = 0.01). Conversely, there was no significant difference in AL elongation between the OK group in the first and second half of the year (0.12 ± 0.07 mm vs 0.15 ± 0.08 mm, p = 0.71). The combination of 0.05 % atropine ophthalmic solution had a significant effect on 1-year AL elongation (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This study provided preliminary evidence that the combination of OK lenses and 0.05% atropine ophthalmic solution can significantly enhance the effectiveness of myopia control.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102282"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 0.01% atropine eye drops combined with different optical treatments to control low myopia in Chinese children","authors":"Xindan Cao ,&nbsp;Ziqi Guo ,&nbsp;Zhiyuan Wei ,&nbsp;Hongfei Ming ,&nbsp;Bing Ma ,&nbsp;Yue Zhao ,&nbsp;Yue Zhang ,&nbsp;Lei Guo ,&nbsp;Cheng Peng","doi":"10.1016/j.clae.2024.102317","DOIUrl":"10.1016/j.clae.2024.102317","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate the efficacy and safety of 0.01% atropine (AT) in combination with different optical treatments for controlling myopia in Chinese children.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 341 Chinese children aged 6–11 years with myopia between −0.50 D and −3.0 D between January 2022 and May 2023. The fast-progressing, myopic children received three optical treatments combined with 0.01 % atropine: 75 children with single-vision spectacles and atropine (SV + AT), 162 children with defocus-incorporated multi-segment spectacles and atropine (DIMS + AT), or 104 children with orthokeratology and atropine (OK + AT). The changes in spherical equivalent refraction (SER), axial length (AL), intraocular pressure (IOP), and amplitude of accommodation (AMP) were observed at 6-month and 1-year intervals.</div></div><div><h3>Results</h3><div>After controlling for baseline variables, at 6 months, the increase in adjusted AL was significantly greater in the SV + AT group than in the DIMS + AT group (difference = 0.13 mm, 95 % CI: 0.07–0.20, P &lt; 0.05) and in the OK + AT group (difference = 0.09 mm, 95 % CI: 0.09–0.17, P &lt; 0.05). A more significant progression in adjusted SER was also observed in the SV + AT group than in the DIMS group (difference = −0.20D, 95 % CI: −0.29 to −0.11, P &lt; 0.05). At 12 months, the greatest increase in adjusted AL was observed in the SV + AT group, with a statistically significant difference of 0.24 mm (95 % CI: 0.19–0.29, P &lt; 0.05) compared with the DIMS group and a difference of 0.19 mm (95 % CI: 0.13–0.25, P &lt; 0.05) compared with the OK + ST group. Similarly, a more significant progression in adjusted SER was observed in the SV + AT group than in the DIMS group (difference = −0.36 D, 95 % CI: −0.48 to −0.24, P &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>This study suggested that 0.01% atropine combined with DIMS or orthokeratology may be viable for controlling low myopia in fast-progressing, myopic children.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102317"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of back optic zone diameter (BOZD) in orthokeratology on axial length elongation: A meta-analysis and systematic review","authors":"Zhiming Gu ,&nbsp;Ruiyu Yang ,&nbsp;Canyu Wang ,&nbsp;Mengxiong Luo ,&nbsp;Xiangyu Chen ,&nbsp;Helong Piao ,&nbsp;Xuan Liao","doi":"10.1016/j.clae.2024.102316","DOIUrl":"10.1016/j.clae.2024.102316","url":null,"abstract":"<div><h3>Purpose</h3><div>Myopia has emerged as a significant public health concern. Recent studies have demonstrated that Orthokeratology (Ortho-K) can effectively decelerate axial length (AL) growth, with eyes possessing smaller back optical zone diameters (BOZD) exhibiting greater effectiveness compared to those with larger BOZD. This study aims to analyze the impact of Ortho-K with varying BOZD.</div></div><div><h3>Method</h3><div>This systematic review involved the retrieval of articles from eight databases: PubMed, Embase, Web of Science, Cochrane, CNKI, Wanfang, Sinomed, and VIP, covering the period from each database’s inception to January 2024. It compared axial length (AL) changes between smaller and larger back optic zone diameters (BOZD). Review Manager 5.4 was used to statistical analysis and the results presented as weighted mean differences and 95% confidence intervals (CI). This review adheres to the PRISMA guidelines.</div></div><div><h3>Result</h3><div>This systematic review included two randomized controlled trials (RCTs) and five cohort studies (CS), analyzing a total of 702 eyes (352 eyes are treated with Ortho-K and BOZD ≤ 5.5 mm, 350 eyes are treated with Ortho-K and BOZD ≥ 6.0 mm). The findings indicate that the Ortho-K with smaller BOZD significantly reduces AL growth [<em>WMD</em> = −0.13, 95 %<em>CI</em> (−0.16 to −0.10), <em>P</em> &lt; 0.001].</div></div><div><h3>Conclusion</h3><div>The Ortho-K with smaller BOZD prove more effective in controlling myopic AL growth compared with larger BOZD. However, in clinical practice, it is necessary to comprehensively evaluating factors such as patient age, myopia diopter, pupil diameter, higher-order aberration, treatment zone area, and corneal eccentricity to achieve optimized outcomes in improving naked-eye vision and myopia controlling.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102316"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential impact of combined therapy and monotherapy with 0.05% atropine eyedrops and dual focus contact lenses on choroid","authors":"Jiali Zhang,&nbsp;Muhan Zhong,&nbsp;Shuqi Fan,&nbsp;Yanqing Wang,&nbsp;Xue Li,&nbsp;Hao Chen,&nbsp;Jinhua Bao,&nbsp;Yingying Huang","doi":"10.1016/j.clae.2024.102320","DOIUrl":"10.1016/j.clae.2024.102320","url":null,"abstract":"<div><h3>Purpose</h3><div>To investigate changes in the choroid and axial length (AL) during one month of combined therapy and monotherapy with 0.05% atropine and dual-focus soft contact lens (DFCL), and the impact after discontinuation.</div></div><div><h3>Methods</h3><div>Myopic adults randomly received three interventions: 0.05 % atropine, DFCL, and 0.05 % atropine combined with DFCL. Choroidal thickness (ChT), choroidal vascularity index (CVI) and AL were measured at baseline, 3, 7, 14, and 30 days after intervention, and 1, 2, 7, 14, and 30 days after discontinuation.</div></div><div><h3>Results</h3><div>The ChT thickened and AL decreased after one month of combination therapy (24.19 ± 4.13 μm, <em>P</em> = 0.001; −40.35 ± 9.55 μm, <em>P</em> = 0.024) or 0.05 % atropine (20.52 ± 4.35 μm, <em>P</em> = 0.008; −8.07 ± 7.22 μm, <em>P</em> = 0.002) but not DFCL (8.95 ± 4.25 μm, <em>P</em> &gt; 0.999; −14.89 ± 7.28 μm, <em>P</em> &gt; 0.999). The increase in ChT and decrease in AL persisted for 2 days after 0.05 % atropine was discontinued, persisted for 7 days and 14 days after combination therapy was discontinued. There was no significant change in the CVI after one month use or withdrawal of any intervention (<em>P</em> &gt; 0.999). After one month of combination therapy, significant correlations were observed between the baseline CVI and changes in ChT (<em>r</em> = 0.485, <em>P</em> = 0.035) or AL (<em>r</em> = -0.589, <em>P</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>Monotherapy involving 0.05% atropine or the combination of 0.05% atropine with DFCL significantly affected ChT thickening and AL shortening. These changes were maintained for a longer duration post combination intervention. The baseline CVI was associated with changes in ChT and AL during combination treatment.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 1","pages":"Article 102320"},"PeriodicalIF":4.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Initial Validation of the MCL-PRO-CAT: A computerized adaptive test designed to measure multifocal contact lens performance from the patient's perspective.","authors":"Elsa Albero-Ros, Amalia Lorente-Velázquez, David Madrid-Costa, Mariano González-Pérez","doi":"10.1016/j.clae.2025.102378","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102378","url":null,"abstract":"<p><strong>Purpose: </strong>To create a valid and reliable computer-adaptive testing (CAT) tool for assessing Multifocal Contact Lens (MCL) performance in presbyopic individuals, ensuring high precision. The self-administered tool will initially be accessible online in Spanish.</p><p><strong>Methods: </strong>Five steps were followed for the correct development of the instruments: item bank development, item refinement phase, item response theory calibration of the refined item bank, CAT simulations and design, and an initial validation study. A total of 1163 presbyopic patients were involved in the over-all study. Convergent validity was assessed by comparing results to the CLDQ-8 questionnaire, and repeatability assessment was performed two weeks after the initial completion.</p><p><strong>Results: </strong>The final item bank consisted of 108 items assessing various relevant domains for MCL performance evaluation. The calibration study showed a person separation index of 4.69 and a reliability of 0.96 along with a measurement precision of 0.27. The final CAT distinguished between 16 levels of MCL performance by presenting an average of 10.61  ± 1.00 items per patient, with an average completion time of 3:04 ± 1:24 min. Signs of convergent validity showed a correlation of 0.73 and repeatability was assessed showing an intraclass Correlation Coefficient of 0.881 with a 95% Confidence Interval 0,815-0,924, and Limits of Agreement of  ± 1.07.</p><p><strong>Conclusion: </strong>The MCL-PRO-CAT is a groundbreaking tool for evaluating MCL performance in presbyopic individuals. With automated scoring and fewer items, it was feasible, valid, and precise, enhancing clinical practicality.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102378"},"PeriodicalIF":4.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}