{"title":"Efficacy of 265 nm ultraviolet C light in the treatment of multi-drug resistant Pseudomonas aeruginosa keratitis in vitro and in an in vivo murine model","authors":"Lakshminarayanan Gowtham , Esther Sheba , Savitri Sharma , Dilip Kumar Mishra , Bhupesh Bagga","doi":"10.1016/j.clae.2025.102417","DOIUrl":"10.1016/j.clae.2025.102417","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the <em>in vitro</em> and <em>in vivo</em> efficacy of 265 nanometer (nm) ultraviolet C (UVC) light using 1.93 mW/cm<sup>2</sup> against multi-drug-resistant (MDR) <em>Pseudomonas aeruginosa</em> (<em>P. aeruginosa</em>) keratitis.</div></div><div><h3>Methods</h3><div>The effect of UVC light was studied on two clinical isolates of <em>P. aeruginosa</em>. Isolate 1 was ciprofloxacin-susceptible, and isolate 2 was MDR (but ceftazidime-susceptible). For the <em>in vitro</em> evaluation, <em>P. aeruginosa</em> isolates (100 μl, 1*10<sup>8</sup> CFU/ml) were spread on Muller-Hinton solid agar surface and exposed to UVC light for 1, 5, 10, 15, and 30 seconds (s). For the <em>in vivo</em> study, the right eyes of C57BL mice were infected with the <em>P. aeruginosa</em> isolates (5 μL, 1*10<sup>8</sup> CFU/ml) in two sets with isolates 1 and 2, respectively. The first set (n = 24) was randomized into four groups: a) untreated, b) UVC light 15 s exposure twice daily for two days, c) topical ciprofloxacin 0.3 %w/v twice daily for two days, d) topical ciprofloxacin 0.3 %w/v two-hourly for two days. The second set with MDR <em>P. aeruginosa</em> (n = 24) was treated similarly except for group d (which received topical ceftazidime 5 %w/v two hourly for two days). The left eyes were used to evaluate the safety of applied treatments without inducing infection. At 48 hours (hrs), eyes were enucleated and subjected to microbiological and histopathology analysis.</div></div><div><h3>Results</h3><div><em>In vitro</em>, the UVC light exposure resulted in a clear inhibition area for exposures of 15 and 30 s. In the <em>in vivo</em> murine model, UVC light prevented overall clinical severity (p < 0.05) at 24 and 48 hrs by both isolates. Microbiological assessment at 48 hrs showed no growth of organisms in UVC light-treated corneas of either of the sets, similar to an observed treatment with ciprofloxacin (set 1) and ceftazidime (set 2).</div></div><div><h3>Conclusion</h3><div>265 nm UVC light showed an exposure-dependent <em>in vitro</em> bactericidal effect on <em>P. aeruginosa</em>. The <em>in vivo</em> studies showed that UVC light eliminated both strains of <em>P. aeruginosa</em> with an equivalent efficacy.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102417"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scott A Read, Stephen J Vincent, Luisa H Colorado, Joanne M Wood, Michael J Collins
{"title":"The impact of toric contact lens correction upon functional near visual performance with digital devices.","authors":"Scott A Read, Stephen J Vincent, Luisa H Colorado, Joanne M Wood, Michael J Collins","doi":"10.1016/j.clae.2025.102415","DOIUrl":"https://doi.org/10.1016/j.clae.2025.102415","url":null,"abstract":"<p><strong>Purpose: </strong>Although it is well known that astigmatism correction with toric contact lenses improves clinical vision measures, their effects on real-world visual performance using digital devices such as smartphones are less well understood. This study aimed to examine how toric soft contact lenses impact functional near visual performance with a smartphone, in comparison to spherical equivalent contact lenses.</p><p><strong>Methods: </strong>Fifteen healthy young adults (mean age 23.6 ± 2.8 years) with low to moderate astigmatism (-0.50 D to -1.50 D) participated in this prospective, repeated measures randomised crossover trial. Either toric or best sphere soft daily disposable contact lenses (lens material Verofilcon A) were worn during two separate study visits. At each visit, near visual acuity (VA) was assessed, and participants performed a reading task on a smartphone with both high and low contrast text displays. A mobile eye tracker was worn during the reading task to track objective measures of visual fatigue such as palpebral aperture height and near focusing demand.</p><p><strong>Results: </strong>Both high and low contrast near VA were significantly better with the toric correction compared to the best sphere (p = 0.001). While reading on a smartphone, the average reading speed was not significantly different between the sphere and toric lenses (p = 0.18). Significantly fewer errors were made while reading with the toric lens compared to the best sphere lens for the low contrast (p = 0.04), but not for high contrast text (p = 0.4). For measures of palpebral aperture height, and focusing demand, a significant lens by time interaction was found (both p < 0.05), with a significantly greater focusing demand and a narrower palpebral aperture observed towards the end of the reading task with the best sphere lens.</p><p><strong>Conclusion: </strong>Significant visual and functional benefits were found for digital near visual tasks associated with toric contact lens correction.</p>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":" ","pages":"102415"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vision in times of war: Managing keratoconus in children and the role of omega-3 and vitamins in supporting eye health","authors":"V. Tepleshniuk , Y. Barinov","doi":"10.1016/j.clae.2025.102411","DOIUrl":"10.1016/j.clae.2025.102411","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102411"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James S. Wolffsohn , Moonisah Ayaz , Stefan Bandlitz , Franziska von der Höh , Andreas Ebner , Jennifer P. Craig
{"title":"Optimising the methodology for assessing tear meniscus height using digital imaging","authors":"James S. Wolffsohn , Moonisah Ayaz , Stefan Bandlitz , Franziska von der Höh , Andreas Ebner , Jennifer P. Craig","doi":"10.1016/j.clae.2025.102419","DOIUrl":"10.1016/j.clae.2025.102419","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the optimum method for assessing tear meniscus height using digital imaging.</div></div><div><h3>Method</h3><div>The tear meniscus of 38 participants (mean age 32.5 ± 10.6 years, 45 % male) was video recorded three times, each for a period of five seconds following two natural blinks using the Oculus Keratograph 5M, first with infrared and subsequently with visible (white) light. Still images at 0.5 s intervals from the last blink, up to 5 s, were extracted from the video recording and the lower eyelid tear meniscus height was measured using ImageJ at seven locations; immediately below pupil centre and at 1 mm, 3 mm and 6 mm, nasally and temporally. Dryness symptoms were assessed with the Ocular Surface Disease Index (OSDI) and tear film stability with non-invasive tear breakup time with the Oculus Keratograph 5M.</div></div><div><h3>Results</h3><div>A significant difference in the tear meniscus height was measured with infrared (0.29 ± 0.08 mm) compared to white light (0.27 ± 0.08 mm; p < 0.001). Tear meniscus height increased significantly with repeated measurement (first: 0.27 ± 0.08 mm; second 0.27 ± 0.08; 0.28 ± 0.09; p = 0.005). In each case, following a significant decrease immediately after a blink, the tear meniscus height was stable between 1.0 and 2.5 s and increased thereafter (p < 0.001). A consistent tear meniscus height measurement was achieved by measuring within 1 mm of the pupil midline, but increased more peripherally (p < 0.001). Differences in height, while statistically significant, were not clinically significant except in the peripheral measurements.</div></div><div><h3>Conclusion</h3><div>Tear meniscus height should be measured in a consistent manner, either with infrared or white light. A single measurement from the top of the meniscus to the eyelid margin within 1 mm of the pupil midline, from an image captured 1.0 to 2.5 s after two blinks, is sufficient.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102419"},"PeriodicalIF":4.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is the Elimination of Keratoconus in Our Hands?","authors":"Gabriel Fickett, Shehzad A. Naroo","doi":"10.1016/j.clae.2025.102414","DOIUrl":"10.1016/j.clae.2025.102414","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 3","pages":"Article 102414"},"PeriodicalIF":4.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fan Yang , Jiayan Chen , Qiuyue Zhang , Wei He , Xingru He , Guanghao Qin , Sile Yu
{"title":"Letter to the editor RE “The effectiveness of orthokeratology lenses in myopia prevention and control.”","authors":"Fan Yang , Jiayan Chen , Qiuyue Zhang , Wei He , Xingru He , Guanghao Qin , Sile Yu","doi":"10.1016/j.clae.2025.102418","DOIUrl":"10.1016/j.clae.2025.102418","url":null,"abstract":"","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102418"},"PeriodicalIF":4.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuehan Luo , Juan Xie , Wenchuan Liao , Yue Luo , Jia Liu , Yuxia Liu , Yangyu Tang , Yunchun Zou
{"title":"Improved control efficacy of a novel aspherical orthokeratology lens compared with the traditional three-zone spherical lens in a single-blind randomized clinical trial","authors":"Yuehan Luo , Juan Xie , Wenchuan Liao , Yue Luo , Jia Liu , Yuxia Liu , Yangyu Tang , Yunchun Zou","doi":"10.1016/j.clae.2025.102404","DOIUrl":"10.1016/j.clae.2025.102404","url":null,"abstract":"<div><h3>Purpose</h3><div>Orthokeratology lenses slow myopia progression by over 50% on average. Efficacy and optical outcomes of aspherical and spherical orthokeratology lens designs in controlling myopia progression are compared, focusing on axial length (AL), choroidal thickness (CHT), and relative peripheral refractive errors.</div></div><div><h3>Methods</h3><div>A multicenter, single-blind, randomized controlled trial was conducted in Sichuan, China (2022–2023), with 30 participants aged 8–13 (mean age 10.8 ± 1.8 years; 70 % male). Inclusion criteria embraced refractive errors between −0.75 and −6.00 D. Each eye was randomly assigned to a spherical or aspherical lens. Measurements included AL and central corneal thickness and retinal defocus at baseline and 3, 6, 9, and 12 months.</div></div><div><h3>Results</h3><div>No baseline differences were observed between groups (P > 0.05). Throughout the 12 months, axial length (AL) increases were reported as 0.04 ± 0.18 mm and 0.25 ± 0.23 mm in the aspherical and spherical groups, respectively (P < 0.001). The aspherical lens produced greater corneal reshaping (nasal: 65.67 μm vs. 61.23 μm, P = 0.008; temporal: 68.03 μm vs. 61.07 μm, P = 0.002) and less hyperopic defocus (RDV30-45 and RDV45-53; P < 0.001). The change in AL correlated positively with the change in RDV. No other significant between-group differences in CHT changes were observed (P = 0.203).</div></div><div><h3>Conclusion</h3><div>Aspherical orthokeratology lenses show superior control of axial length compared to spherical lens designs due to increased sagittal height and peripheral myopic defocus within 15°-45° of retinal eccentricity.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102404"},"PeriodicalIF":4.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Andrew, Aaron T. Zimmerman, Melissa D. Bailey
{"title":"The relationship between soft contact lens adverse events and corneal sagittal depth","authors":"Matthew Andrew, Aaron T. Zimmerman, Melissa D. Bailey","doi":"10.1016/j.clae.2025.102413","DOIUrl":"10.1016/j.clae.2025.102413","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine if individuals who develop soft-contact-lens adverse events (corneal infiltrative events or microbial keratitis) have a shallower corneal sagittal depth than the population mean.</div></div><div><h3>Methods</h3><div>Participants (N = 25) with an adverse event within the last two years were recruited for a prospective, case-control study. Corneal sagittal depth was calculated from topography (central keratometry, eccentricity, 12 mm diameter) for comparison with an historical control (published, population mean ± SD = 2.74 ± 0.15 mm, N = 18,387 eyes) using one-sample t-tests. Bland-Altman analyses compared topography-calculated sagittal depth to measurements from anterior segment optical coherence tomography (AS-OCT) images (12 mm chord), for validation. Contact lens movement and fit were measured from images/videos.</div></div><div><h3>Results</h3><div>Participants (mean ± SD age = 27.4 ± 10.4 years, range 18 to 65 years) were predominantly female (19 of 25). Topography-calculated sagittal depth was slightly larger than, but highly correlated with, AS-OCT measurements (mean of the differences ± SD = 0.14 ± 0.08 mm, t = 8.97, p < 0.0001; r = 0.82, p < 0.0001). The mean ± SD sagittal depth for participants (2.64 ± 0.14 mm) was significantly shallower than the population mean (t = − 3.52, p = 0.002). Primary gaze contact lens movement (mean ± SD) was 0.24 ± 0.17 mm, range: 0.06 to 0.82 mm and up gaze was 0.45 ± 0.33 mm, range: 0.05 to 1.16 mm.</div></div><div><h3>Conclusions</h3><div>Contact lens wearers with adverse events had a corneal sagittal depth that was significantly shallower than the population mean. These data suggest that one-size-fits-most soft contact lenses may have a sagittal depth that is too deep for patients with a shallower-than-typical corneal sagittal depth, which presumably inhibits the eye’s natural defenses. Future studies should compare the relative risk of corneal sagittal depth to other known risk factors and determine clinical guidelines for fitting soft contact lenses based on sagittal depth.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102413"},"PeriodicalIF":4.1,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ngozika N. Ezinne , Samuel Kyei , Chukwuemeka Junior Obinwanne , Tuwani A. Rasengane , Khathutshelo Percy Mashige , Kingsley E. Agho , Randy Asiamah , Bernadine N. Ekpenyong , Stephen Ocansey , Antor O. Ndep , Sylvester Kyeremeh , Godwin Ovenseri-Ogbomo , Edgar Ekure , Kelechi C. Ogbuehi , Kovin Shunmugan Naidoo , Nalova Westbrook , Haile Waretow , Kofi Asiedu , Uchechukwu L. Osuagwu , All a u t h o r s are members of the Centre for Eyecare Public Health Intervention Initiative CEPHII
{"title":"Normative corneal biometric parameters in African populations: A systematic review and meta-analysis","authors":"Ngozika N. Ezinne , Samuel Kyei , Chukwuemeka Junior Obinwanne , Tuwani A. Rasengane , Khathutshelo Percy Mashige , Kingsley E. Agho , Randy Asiamah , Bernadine N. Ekpenyong , Stephen Ocansey , Antor O. Ndep , Sylvester Kyeremeh , Godwin Ovenseri-Ogbomo , Edgar Ekure , Kelechi C. Ogbuehi , Kovin Shunmugan Naidoo , Nalova Westbrook , Haile Waretow , Kofi Asiedu , Uchechukwu L. Osuagwu , All a u t h o r s are members of the Centre for Eyecare Public Health Intervention Initiative CEPHII","doi":"10.1016/j.clae.2025.102412","DOIUrl":"10.1016/j.clae.2025.102412","url":null,"abstract":"<div><h3>Background</h3><div>Despite the importance of corneal biometric parameters in ophthalmology, there is limited comprehensive data on these measurements in Sub-Saharan African (SSA) populations. This study systematically reviewed the evidence on corneal biometric parameters of Sub-Saharan African populations, focusing on their variability, influencing factors, and implications for clinical practice and public health interventions.</div></div><div><h3>Methods</h3><div>A systematic review and meta-analysis were conducted following PRISMA guidelines. Eligible studies published between January 2003 and December 2023 were identified through comprehensive searches in PubMed, Scopus, and Web of Science, with a specific focus on African populations. Inclusion criteria comprised non-interventional studies reporting central corneal thickness (CCT), corneal curvature, radius of curvature, or horizontal corneal diameter (HCD) of eyes of continental Africans. Data were synthesized using random-effects meta-analyses, with heterogeneity assessed using the I<sup>2</sup> statistic. Subgroup analyses examined variations by geographic region, measurement instrument, and sex.</div></div><div><h3>Results</h3><div>Twenty-eight studies with a total of 14,009 participants were included. The pooled mean CCT was 553.35 µm (95 % CI: 548.52–558.18 µm), with regional variations ranging from 555.66 µm in West Africa to 510.17 µm in Southern Africa. Males exhibited slightly higher CCT values compared to females (539.11 µm vs. 533.78 µm). Additional parameters assessed included mean corneal curvature (43.07 D), radius of curvature (7.70 mm), and HCD (11.59 mm). Variability in the measurements was attributed to demographic, geographic, and methodological factors.</div></div><div><h3>Conclusions</h3><div>Corneal biometric parameters exhibit substantial regional and demographic variability in SSA. These findings underscore the importance of population-specific data in enhancing diagnostic precision and guiding the development of regionally tailored clinical protocols. Further research is needed to address current knowledge gaps and improve eye care outcomes across the African continent.</div></div><div><h3>Funding</h3><div>This research received no specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102412"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rita Seco , Rute J. Macedo-de-Araújo , José M. González-Méijome
{"title":"Influence of scleral lens removal and reapplication on fluid reservoir thickness and visual quality after 5 h of lens wear","authors":"Rita Seco , Rute J. Macedo-de-Araújo , José M. González-Méijome","doi":"10.1016/j.clae.2025.102392","DOIUrl":"10.1016/j.clae.2025.102392","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess changes in fluid reservoir (FR) thickness and optical quality following the removal and reapplication of a scleral lens worn for 5 h in participants with regular and irregular corneas.</div></div><div><h3>Methods</h3><div>Two groups with 10 patients were recruited: IC Group-Irregular Cornea; RC Group-Regular Cornea. Both groups were fitted with a diagnostic 16.4 mm scleral lens (hexafocon A). FR thickness was measured with optical coherence tomography (MOCEAN 4000, MOPTIM, Shenzhen Slton Technology Co. Ltd., China l), high and low contrast visual acuity was measured with ETDRS, whole eye aberrometry was assessed with IRx3 Wavefront Aberrometer (ImaginEyes, Orsay, France) for a 5 mm pupil diameter, and the light disturbance under dim light conditions was assessed with Light Distortion Analyzer (LDA, Binarytarget, Portugal). Measurements were taken at 10 min and after 5 h lens wear, as well as following lens removal and reapplication.</div></div><div><h3>Results</h3><div>Following lens removal and reapplication, FR thickness significantly increased in RC Group (294.3 ± 137.5 to 337.2 ± 141.4 µm, p = 0.005), and in IC Group (311.5 ± 150.3 to 339.5 ± 150.7 µm, p = 0.005, Wilcoxon). Although minor visual fluctuations of 2 letters were found in high and low contrast visual acuity, no statistically significant differences were observed after lens reapplication. Regarding the size and irregularity of light distortion, no statistically significant differences were observed in either group. The aberrometry results demonstrated significant changes, with an increase in comatic vertical aberrations (p = 0.037, Wilcoxon), observed exclusively in IC Group after lens removal and reapplication.</div></div><div><h3>Conclusion</h3><div>Practitioners should be aware that removing and reapplying a scleral lens with fresh saline solution will increase the FR thickness. However, this increase may not have a significant or clinically meaningful impact on visual acuity, light disturbance size or optical quality as measured by aberrometry.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102392"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}