Cytojournal最新文献

{"title":"A rare and challenging case of uterine mass successfully reported in a cervical smear.","authors":"Waleed Al Amri, Ishaq Al Salmi, Safia K Al Nabhani, Bushra S Al Hatrooshi","doi":"10.25259/Cytojournal_37_2022","DOIUrl":"10.25259/Cytojournal_37_2022","url":null,"abstract":"A 65-year-old postmenopausal woman, gravida 7 and para 5 from a rural hospital, presented with the lower abdominal pain associated with dysuria. A contrast-enhanced computed tomography was done, which showed a mass occupying the uterus and part of the mass is protruding into the upper vagina. A Papanicolaou (Pap) smear test was performed. e images are shown in [Figure 1]","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"35"},"PeriodicalIF":1.9,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41116472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prominent emperipolesis in breast lesion: A diagnostic challenge.","authors":"Rishabh Sahai, Divya Singh, Vikas Shrivastava, Mukul Singh, Brijnandan Gupta","doi":"10.25259/Cytojournal_22_2022","DOIUrl":"10.25259/Cytojournal_22_2022","url":null,"abstract":"","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"32"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytopathologic features of epithelioid hemangioendothelioma including touch imprints for rapid on-site evaluation.","authors":"Mega Lahori, Amir Dehghani, Christina Wilson, Wyanne Law, Narasimhan Agaram, Rajmohan Murali, Carlie Sigel","doi":"10.25259/Cytojournal_57_2022","DOIUrl":"10.25259/Cytojournal_57_2022","url":null,"abstract":"<p><strong>Objectives: </strong>Epithelioid hemangioendothelioma (EHE) is a vascular tumor of intermediate malignant potential, which presents as infiltrative lesions involving multiple organs. We reviewed our institutional experience with the cytologic diagnosis of this neoplasm including the performance of rapid on-site evaluation (ROSE).</p><p><strong>Material and methods: </strong>From our institutional database, we identified 29 cytology specimens, obtained between 2012 and 2020, from 21 patients with biopsy confirmation of EHE. ROSE and final diagnosis were compared. All cytology slides were reviewed, and selected cytologic features were recorded.</p><p><strong>Results: </strong>The cohort included 29 specimens comprising 17 (59%) from liver, 6 (21%) from lung, 2 (7%) from lymph node, and 4 (14%) from other sites. At ROSE, 8/27 (30%) were reported inadequate, yet on review, all cases contained scattered cells typical of EHE in the touch imprint air-dried slides including two cases reported with a final diagnosis of non-diagnostic. All cases contained epithelioid and plasmacytoid cells with ovoid nuclei, fine chromatin, delicate (or biphasic) cytoplasm, and scattered cells with delicate, elongated cytoplasmic tails. The majority 26/29 (90%) of cases had multi-nucleated and multi-lobated nuclei. Intracytoplasmic lumens/blister cells were in 17/29 (59%), and a subset had erythrocytes therein (4/29, 14%). Metachromatic fibromyxoid or fibrotic stroma fragments were commonly seen (23/29, 79%). Mitoses and necrosis were absent in all cases. Of 11 tested cases, <i>WWTR1::CAMTA1</i> and <i>YAP1::TFE3</i> fusions were detected in nine and two cases, respectively.</p><p><strong>Conclusion: </strong>EHE has distinctive cytologic features which are often under-recognized during ROSE.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"29"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41177314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual case of parietal scalp swelling without palpable swelling in head and neck region.","authors":"Priyanka Gautam,&nbsp;Anshi Singh,&nbsp;Vikas Shrivastava,&nbsp;Divya Singh,&nbsp;Mukul Singh,&nbsp;Brijnandan Gupta","doi":"10.25259/Cytojournal_26_2022","DOIUrl":"10.25259/Cytojournal_26_2022","url":null,"abstract":"","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"33"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of the human papillomavirus DNA chip test as a complementary method for cervical cytology.","authors":"Rae-Young Lee,&nbsp;Joo-Yeon Koo,&nbsp;Nah-Ihm Kim,&nbsp;Sung-Sun Kim,&nbsp;Jong-Hee Nam,&nbsp;Yoo-Duk Choi","doi":"10.25259/Cytojournal_40_2020","DOIUrl":"10.25259/Cytojournal_40_2020","url":null,"abstract":"<p><strong>Objectives: </strong>As a convenient and economical method of screening cervical cancer and precancerous pathologies, the Papanicolaou smear (Pap smear) has been most widely used. Nevertheless, it requires cytological changes for making diagnoses and reportedly has a high false-negative rate. In this study, the usefulness of the human papillomavirus (HPV) DNA chip test as a complementary method that can compensate for the defect of the Pap smear was investigated.</p><p><strong>Material and methods: </strong>Of the 6516 patients who simultaneously underwent a Pap smear and an HPV DNA chip test at Chonnam National University Hospital between January 2015 and December 2016, 1897, an initial PAP smear-negative patients who had undergone an additional Pap smear during their 2-year follow-up period were selected for this study. Of the subject patients, 281 underwent a cervical biopsy.</p><p><strong>Results: </strong>The Pap smear follow-up of an initial Pap smear-negative subjects showed 53 (75.7%) HPV high-risk positive cases in the cytology low-grade lesion group (70 cases) and 46 (97.8%) HPV high-risk positive cases in the cytology high-grade lesion group (47 cases). The 281 biopsy cases included 67 biopsy low-grade lesion cases and 74 biopsy high-grade lesion cases, of which there were 45 (67.2%) and 67 (90.5%) HPV high-risk positive cases, respectively. The follow-up cytology on the high-risk HPV-positive subjects showed that the ratio of their high-grade lesions was 260.8 times greater than that of the high-risk HPV-negative subjects (OR = 260.8 and 95% CI: 36.1 and 1886.1); and their biopsy showed that the ratio of their high-grade lesions was 102.7 times greater than that of the HPV-negative subjects (OR = 102.7 and 95% CI: 14.0 and 753.3).</p><p><strong>Conclusion: </strong>The complementary use of the HPV DNA chip test may be useful in increasing the accuracy of screening examinations for the early diagnosis of uterine cervix cancer when combined with the Pap smear.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"34"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41162188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of grape-based stain (Vinatela) on cervical cytology: A Peruvian validation study.","authors":"Jeel Salazar Moya,&nbsp;Victor Rojas-Zumaran,&nbsp;Carlos Vegas,&nbsp;Amalia Salafia,&nbsp;Hans Contreras-Pulache","doi":"10.25259/Cytojournal_19_2021","DOIUrl":"10.25259/Cytojournal_19_2021","url":null,"abstract":"<p><strong>Objectives: </strong>The Papanicolaou's (Pap's) stain is used for cervical cancer screening. It employs toxic-carcinogenic expensive reagents, which may not be easily accessible to many communities worldwide. The objective of this study was to validate the grape-based alcohol-extracted dye (Vinatela) on normal cervical samples for the Pap test.</p><p><strong>Material and methods: </strong>Samples of the two grape species were collected from two vineyards through the Agroindustrial Research Institute of Universidad Privada San Juan Bautista. The dye extraction from the grape species and the dye performance to stain cells were conducted in three phases: (a) direct staining with pre-fermentation wine products, (b) direct fragmentation of grapes and direct staining with shells of the grapes, and (c) alcoholic extraction of the dye. Vinatela obtained from two species (<i>Vitis vinifera</i> \"<i>Tempranillo</i>\" and \"<i>Malbec</i>\") and posterior staining of cervical samples. We conducted a double-blind validation on 30 cervical samples.</p><p><strong>Results: </strong>The basophilic components of the cervical cells were stained. Alcoholic extraction staining protocol had a low yield. The nuclear and cytoplasmic borders, the nuclear details, and the polymorphonuclear nuclei were stained with Vinatela and could be differentiated during nuclear coloration. The initial staining protocol was 10- 20 min × (mean ~12 min) staining time. We noted a slightly better staining with <i>V. v. Tempranillo</i> as compared to <i>V. v</i>. Malbec (<i>P</i> = 0.045).</p><p><strong>Conclusion: </strong>Cervical cells stained with Vinatela stain from two grape species cultivated in the Southern of Peru, showed basophilic nuclear details.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"30"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41167262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytomorphological findings in drug defaulters of tuberculous lymphadenitis.","authors":"Aarti Kumari,&nbsp;Sana Ahuja,&nbsp;Sachin Bajaj,&nbsp;Sufian Zaheer,&nbsp;Vinod Chaitanya,&nbsp;Yatish Agarwal,&nbsp;Ratan Gupta,&nbsp;Sunil Ranga","doi":"10.25259/Cytojournal_16_2023","DOIUrl":"10.25259/Cytojournal_16_2023","url":null,"abstract":"<p><strong>Objectives: </strong>Tuberculosis (TB) is an important health problem specially in the developing countries. Although effective chemotherapy is available, compliance of patient is a major challenge. The aim of this study was to describe cytomorphological features of drug defaulters on lymph node on fine-needle aspiration cytology (FNAC) and compare it with newly diagnosed cases.</p><p><strong>Material and methods: </strong>A cross-sectional study was done for a period of 18 months, in which all patients having tuberculous lymphadenitis were included after taking detailed history regarding previous anti-TB drug intake. Cytomorphological findings in drug defaulters were evaluated and compared with newly diagnosed cases.</p><p><strong>Results: </strong>There were a total of 150 cases with 120 newly diagnosed and 30 drug defaulters. Splintered epithelioid cell granuloma was seen in 40% of drug defaulters, while it was absent in case of newly diagnosed cases (<i>P</i> < 0.0001). Well-formed epithelioid cell granuloma was most commonly seen in newly diagnosed cases (65.83%) followed by poorly formed granuloma (26.67%). Another significant finding was distribution of eosinophils which were significantly high in case of drug defaulters (56.67%) (<i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>Cytomorphological findings can help in identification of the drug defaulters on FNAC and thus plan further line of treatment.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"31"},"PeriodicalIF":1.9,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic clues for hyalinizing trabecular tumor on fine needle aspiration cytology.","authors":"Lone Nielsen,&nbsp;Ana María Colino Gallardo,&nbsp;Pablo Pérez Alonso,&nbsp;Luis Ortega Medina,&nbsp;Esthefanía Latorre García,&nbsp;Cristina Díaz Del Arco,&nbsp;Reyes Bergillos Jiménez,&nbsp;Lorenzo Alarcón García,&nbsp;Marta Cruz Blanco,&nbsp;Jesús Vega González,&nbsp;Montserrat De la Torre Serrano,&nbsp;María Jesús Fernández-Aceñero","doi":"10.25259/Cytojournal_34_2023","DOIUrl":"10.25259/Cytojournal_34_2023","url":null,"abstract":"<p><strong>Objectives: </strong>The hyalinizing trabecular tumor (HTT) is a rare benign neoplasm of the thyroid gland. This neoplasm has overlapping cytological features with Papillary Thyroid Carcinoma, Medullary Carcinoma and Follicular Neoplasm with Nuclear Features of Papillary Carcinoma. This can lead to misdiagnosis of malignancy in fine needle aspiration (FNA) cytology specimens with unnecessary total thyroidectomy. The aim of this study is to determine if there are some cytological features that could help us to suspect HTT on FNA specimens and avoid radical surgery.</p><p><strong>Material and methods: </strong>With this purpose we have collected 6 cases diagnosed of HTT in Hospital Clínico San Carlos of Madrid (Spain) in the last 10 years and reviewed the cytological specimens.</p><p><strong>Result: </strong>We conclude that the presence of hyaline material in FNA specimens of HTT is a constant feature being a diagnostic clue. We must be cautious not to confuse it with dense colloid or amyloid material, the latter seen in Medullary Carcinoma. Papillary architecture and fibrovascular cores are not present in a HTT. Special stains as ki-67, calcitonin and Congo Red staining could help us in achieving the correct diagnosis.</p><p><strong>Conclusion: </strong>We feel the cytopathologists must be aware of the distinguishing features of this lesion, mainly the typical hyaline material to achieve a proper diagnosis and be able to reduce unnecessary aggressive management of these patients.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"19"},"PeriodicalIF":1.9,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10559490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of cervicovaginal Pap smears in newly established tertiary care medical institute.","authors":"Manas Ranjan Sethy,&nbsp;Jitendra Singh Nigam,&nbsp;Ashutosh Rath,&nbsp;Abhimanyu Sharma,&nbsp;Shailaja Prabhala,&nbsp;Immanuel Pradeep","doi":"10.25259/Cytojournal_8_2023","DOIUrl":"10.25259/Cytojournal_8_2023","url":null,"abstract":"<p><strong>Objectives: </strong>We undertook this study to find out the spectrum of the cervical smear pattern along with the clinical profiles of patients who underwent cervical Papanicolaou (Pap) smear evaluation in our newly started tertiary care center. We also tried to find the possible clinical cause for unsatisfactory smears and factors for epithelial cell abnormality.</p><p><strong>Material and methods: </strong>The present study was a retrospective observational study. Pap smears cases with their clinical findings mentioned on the requisition form and cytopathology observations were retrieved from the archives of the department of pathology. Fisher's exact test was used for statistical analysis.</p><p><strong>Results: </strong>Five hundred and ninety-four cases were included in the study. The most common age group was 36- 40 years. White discharge per vaginum was the most common clinical presentation. The negative for squamous intraepithelial lesions or malignancy was the most common interpretation (86.87%). Cervical erosion had statistically significant associations with unsatisfactory smears, while bacterial vaginosis had with satisfactory smears. Epithelial cell abnormality was seen in 4.62% patients. We observed a statistically significant association of cervical mucoid discharge, and inflammation with \"no epithelial cell abnormality\" cases, while postmenopausal bleeding was associated with \"epithelial cell abnormality\" cases.</p><p><strong>Conclusion: </strong>In the presence of clinical factors like cervical erosion, which may affect the quality of Pap smear, proper sampling techniques are to be used by health-care providers. The careful evaluation of Pap smears, especially in cases of cervical mucoid discharge, postmenopausal bleeding, and inflammatory smears is required to ensure that epithelial cell abnormalities are not overlooked.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"20"},"PeriodicalIF":1.9,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective lung cancer control: An unaccomplished challenge in cancer research.","authors":"Neeraja Panakkal,&nbsp;Asha Lekshmi,&nbsp;Veena Vamadevan Saraswathy,&nbsp;Kunjuraman Sujathan","doi":"10.25259/Cytojournal_36_2022","DOIUrl":"10.25259/Cytojournal_36_2022","url":null,"abstract":"<p><p>Lung cancer has always been a burden to the society since its non-effective early detection and poor survival status. Different imaging modalities such as computed tomography scan have been practiced for lung cancer detection. This review focuses on the importance of sputum cytology for early lung cancer detection and biomarkers effective in sputum samples. Published articles were discussed in light of the potential of sputum cytology for lung cancer early detection and risk assessment across high-risk groups. Recent developments in sample processing techniques have documented a clear potential to improve or refine diagnosis beyond that achieved with conventional sputum cytology examination. The diagnostic potential of sputum cytology may be exploited better through the standardization and automation of sputum preparation and analysis for application in routine laboratory practices and clinical trials. The challenging aspects in sputum cytology as well as sputum-based molecular markers are to ensure appropriate standardization and validation of the processing techniques.</p>","PeriodicalId":49082,"journal":{"name":"Cytojournal","volume":"20 ","pages":"16"},"PeriodicalIF":1.9,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10481856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10180609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}