Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Bibliometric analysis in Scopus of scientific production on the relationship between periodontitis and gastrointestinal cancer (2014 - 2023).","authors":"A-S Asmat-Abanto, A Portocarrero-Reyes, R-E Espejo-Carrera, C-A Minchón-Medina, D-J Timaná-Palacios","doi":"10.4317/medoral.26969","DOIUrl":"https://doi.org/10.4317/medoral.26969","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have suggested that some opportunistic periodontal pathobionts have oncogenic properties. However, few bibliometric studies investigate the relationship between periodontitis and gastrointestinal cancer. This bibliometric study aimed to analyze these epidemiological studies conducted between 2014 and 2023 to guide future research.</p><p><strong>Material and methods: </strong>In March 2024, the Scopus database was explored. The articles selected were subjected to a bibliometric analysis of study designs, trends in annual scientific production, and networks of collaboration among countries. Furthermore, the most outstanding countries, academic institutions, authors and journals with the most significant number of publications and the top most cited articles were analyzed. For this purpose, Microsoft Excel, SPSS and VOSviewer 1.6.20 were used.</p><p><strong>Results: </strong>A total of 123 documents were included for analysis. China contributed the most significant number of publications (33 articles) and the United States had the most significant number of citations (2709). Weimin Ye (h-index:81) and Dominique Michaud (h-index:73) were the most prolific authors (5 articles); Dominique Michaud also had the most citations (470). International Journal of Cancer was the journal with the highest number of articles published (6), in addition to being the publication that had the most citations of these articles (409). Tufts University in the United States had the highest number of citations.</p><p><strong>Conclusions: </strong>Between 2014 and 2023, 123 articles on the relationship between periodontitis and gastrointestinal cancer were published. The largest scientific production was found in China, and the most cited articles were those from the United States. Likewise, the research design most commonly used was the cross-sectional type.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telediagnosis performance of specialists in oral medicine and general dental practitioner using images of oral mucosa lesions in Chile.","authors":"C Morales-Gómez, G Ojeda-Uribe, D Adorno-Farías, A Maturana-Ramirez, I Espinoza-Santander","doi":"10.4317/medoral.26825","DOIUrl":"10.4317/medoral.26825","url":null,"abstract":"<p><strong>Background: </strong>The objective of this research was to evaluate the performance of specialists in oral medicine doing diagnosis of oral mucosa lesions through digital images comparing general dental practitioner in Chile.</p><p><strong>Material and methods: </strong>20 oral medicine specialists from the national registry of specialists in Chile and 20 general dental practitioners were invited to participate. Each participant reviewed 33 cases with digital images of oral mucosa lesions and was asked to submit diagnostic hypotheses. The proportions of correct diagnoses and diagnostic accuracy were determined. Analyses were performed using STATA 16.0.</p><p><strong>Results: </strong>Specialists presented a higher total proportion of correct diagnoses than general dental practioners (86.5% vs 49.2%). Specialists also showed higher sensitivity (88.5% vs 59.3%) and greater specificity (85.8% vs 48.6 %) than general dental practioners in the diagnosis of oral cancer and oral potentially malignant disorders compared to benign oral lesions.</p><p><strong>Conclusions: </strong>In Chile, oral medicine specialists are a reliable alternative to provide diagnostic guidance through e-consult, but its margin of error must be considered.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e49-e55"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of oral manifestations in hematological malignancy patients undergoing chemotherapy: prospective cohort study.","authors":"E-L Mello, N-G Pena, V-A Souza, C-M Silva, L-N Ribeiro, R-F Albuquerque, M Meleti, P Vescovi, J-C Leão, I-H Silva","doi":"10.4317/medoral.26652","DOIUrl":"10.4317/medoral.26652","url":null,"abstract":"<p><strong>Background: </strong>Oral manifestations are frequent in patients with hematological malignancies undergoing chemotherapy and may be directly or indirectly related to drug toxicity. Few studies have assessed the chemotherapy and oral manifestations that patients might develop. Therefore, this study aimed to evaluate the incidence of oral manifestations in patients with hematologic neoplasms during hospitalization and chemotherapy.</p><p><strong>Material and methods: </strong>A Prospective Cohort Study, in which adult patients diagnosed with hematological malignancies undergoing chemotherapy were followed up daily to observe the possible development of oral manifestations. Sociodemographic and oncological data as well as oral manifestations when presented were collected. All the patients underwent photobiomodulation to prevent mucositis. STATA/SE 12.0, and Excel 365 software were used to assess the collected data. Fisher's exact test was used to assess categorical variables.</p><p><strong>Results: </strong>95 patients were included in this study. Sixty four (67,4%) of the patients were male, 31 female (32,6%) and the mean age was 44 years of age (SD 15,1) ranging from 19 to 79. Non-Hodgkin's lymphoma is the most common neoplasm. Cytarabine was the most commonly administered drug used in 72 patients (75,8%). Fungal infections were the most frequent oral manifestations. There was no correlation between the histological diagnosis and the risk of developing oral mucositis.</p><p><strong>Conclusions: </strong>Oral manifestations are frequent in patients with hematological malignancies who are undergoing chemotherapy. Since there is a tendency for increasing cases of hematologic neoplasms annually, it is of paramount importance to know the treatments offered to these patients and the related side effects in order to prevent them and consequently decrease morbimortality.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":"30 1","pages":"e17-e23"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effectiveness of low-level laser therapy in patients undergoing lower third molar extraction: A double-blinded randomized controlled trial.","authors":"M-J Uzeda, A-M Silva, L-N Costa, F-S Brito, G-V Fernandes, R-F Resende","doi":"10.4317/medoral.26894","DOIUrl":"10.4317/medoral.26894","url":null,"abstract":"<p><strong>Background: </strong>The use of low-level laser is a therapeutic resource that has been widely used in medicine in general, which has properties capable of modulating inflammatory effects such as pain, edema, and trismus resulting from oral surgeries for the extraction of impacted third molars. This study aimed to evaluate the effect of laser therapy at two different wave frequencies (660nm and 808nm) in patients undergoing impacted 3rd third lower molar extraction. For this, 30 patients were selected and randomly distributed into three groups with 10 individuals each (Control Group, 660nm Group, and 808nm Group).</p><p><strong>Material and methods: </strong>Each participant, according to their experimental group, received irradiation before the start of each surgery and immediately after the surgical procedure. The data regarding edema, pain intensity, and trismus collected before the surgeries, immediately after, and after seven days were spreadsheeted and analyzed to determine the mean and standard deviation. After the Shapiro-Wilk normality test, differences between the experimental groups were determined using Multiple Analyses of Variance, considering a significance level of 5% (p<0.05).</p><p><strong>Results: </strong>The results showed no statistically significant difference between the experimental groups in the analyzed items. Despite this, both groups irradiated with 660nm and 808nm frequencies experienced a reduction in the perception of postoperative pain, thus suggesting the benefit of using low-power laser therapy as an adjunct in the surgical treatment of impacted lower third molars.</p><p><strong>Conclusions: </strong>Despite the results showing no differences between the groups, using LLLT resulted in lower pain perception in the irradiated participants compared to those in the control group. This fact supports the use of LLLT as an adjuvant therapy in patients undergoing oral surgery procedures to remove impacted third molars.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e129-e134"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of methylprednisolone after third molar surgery. A systematic review and meta-analysis of randomized controlled trials.","authors":"H Libório, T Borges, M Pereira, W Ross, J-C Fernandes, G-V Fernandes, B Leitão-Almeida","doi":"10.4317/medoral.26842","DOIUrl":"10.4317/medoral.26842","url":null,"abstract":"<p><strong>Background: </strong>Extraction of impacted third molars is a standard procedure in dentistry. However, the postoperative inflammation and pain are undesired and uncomfortable. Methylprednisolone has emerged as a possible solution to improve outcomes. This systematic review aimed to evaluate methylprednisolone in the postoperative period of impacted third molars in relation to its efficacy in postoperative pain and edema, dosage regimens, administration forms, and adverse effects.</p><p><strong>Material and methods: </strong>Following the PRISMA guidelines, the focus question was: \"In patients who underwent impacted third molar extraction, what was the effect of methylprednisolone used postoperatively compared to non-use or the use of other medications within the same pharmacotherapeutic group to reduce inflammation and pain?\" PubMed/MEDLINE and Scopus were consulted, and an additional manual was performed. The search included articles published in the last 10 years, with the language restriction to English. The articles were analyzed using the PRISMA principles, with pre-defined eligibility criteria. The data were extracted based on the general necessary information. The risk of bias for the RCTs included was performed using a revised Cochrane risk-of-bias tool for randomized trials, and a meta-analysis was performed.</p><p><strong>Results: </strong>Nine articles were included, and five were quantitatively analyzed. Evaluating the test and control groups (methylprednisolone versus controls), there was no significant heterogeneity for pain at 24 hours (p=0.15, I²=47%) and 7 days (p=0.15, I²=47%), with non-significant effects (p=0.85). In the inter-incisal reduction, there was homogeneity at 48 hours (p=0.96, I²=0%) and 7 days (p=0.37, I²=0%), with a greater reduction in the methylprednisolone group (p<0.01 and p<0.05, respectively).</p><p><strong>Conclusions: </strong>Methylprednisolone is efficient in safely treating patients after third molar extraction, reducing pain, edema, and trismus. It achieved better results for the inter-incisal level than dexamethasone; otherwise, dexamethasone is preferable in minimizing postoperative trismus, presenting superior potential in this specific clinical context.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":"30 1","pages":"e86-e96"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of pain perception after mucogingival surgery in multiple Miller class III/RT2 gingival recessions: A randomized clinical trial.","authors":"A Fernández-Jiménez, A-M García-De-La-Fuente, R Estefanía-Fresco, I Lafuente-Ibañez-de-Mendoza, X Marichalar-Mendia, J-M Aguirre-Urizar, L-A Aguirre-Zorzano, E Ginestal-Gómez","doi":"10.4317/medoral.26906","DOIUrl":"10.4317/medoral.26906","url":null,"abstract":"<p><strong>Background: </strong>Although postoperative pain after mucogingival surgery can modify the patient's daily life, few studies have compared daily postoperative pain in mucogingival surgery considering patient characteristics. The aim of this study was to evaluate postoperative pain in 24 patients with Miller class III/RT2 multiple recessions treated with the modified VISTA (m-VISTA) versus the coronally advanced flap (CAF) with a connective tissue graft (CTG).</p><p><strong>Material and methods: </strong>Data related to pain intensity (PI), pain duration (PD), analgesic drug intake (AI), and time of analgesic need (TAN) were collected in the \"UPV/EHU pain diary\". Other data were also evaluated such as the patient's central sensitization level, pre-surgical pain, dimensions of CTG, and postoperative incidences were included. A descriptive and analytical statistical analysis was performed.</p><p><strong>Results: </strong>PI (m-VISTA = 11.19 vs. CAF = 8.10) and PD (m-VISTA = 25.27 min. vs. CAF = 10.34 min.) were higher in the test group, being statistically significant at 2 and 8 hours. TAN (m-VISTA = 63.58 min. vs. CAF = 53.25 min.) was higher in the test group, while AI was two times higher in the control group (m-VISTA = 15 vs. CAF = 38). An association was observed between PI and both the length of the SCTG and drugs/alcohol consumption.</p><p><strong>Conclusions: </strong>Postoperative pain was greater in the group of patients treated with m-VISTA. However, these patients showed a higher number of risk factors which might have increased or modified their pain symptoms.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":"30 1","pages":"e141-e150"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of vitamin C in dental alveolus healing after dental extraction: A scoping review.","authors":"J Dethlefs-Canto, F Osses-Barría, R Vergara-Zenteno, A Bustos-Ponce, J Villavicencio-Duarte","doi":"10.4317/medoral.26893","DOIUrl":"10.4317/medoral.26893","url":null,"abstract":"<p><strong>Background: </strong>Dental extraction is a common procedure in dentistry. It is accompanied by postoperative pain and inflammation. In addition, it decreases bone volume and density. Vitamin C is an antioxidant and cofactor that promotes the synthesis and maturation of collagen, the proliferation and migration of fibroblasts and osteoblasts, accelerating the final phase of inflammation, promoting healing. The objective of this scoping review is to evaluate the effectiveness of vitamin c in dental alveolus healing after extraction and synthesize the available evidence and tits clinical implications.</p><p><strong>Material and methods: </strong>This review is registered on the Open Science Framework platform (https://osf.io/bstwk/). It was carried out under the PRISMA-ScR protocol, using the question: Is vitamin C effective in alveolar healing in patients undergoing dental extraction? The Pubmed/MEDLINE, Scopus, Web of Science and OPENGREY databases were used. Limiting itself to primary studies.</p><p><strong>Results: </strong>A total of 287 articles were identified, applying selection criteria, 3 were included. Of a total of 135 patients, 59.8% were administered vitamin C; 46.6% 600 mg, 34.2% 500 mg and 19.2% 1500 mg. A decrease in pain, inflammation, probing depth and mesiodistal length of the socket was observed.</p><p><strong>Conclusions: </strong>The role of vitamin C is essential for healing, and therefore, bone regeneration after tooth extraction, reducing adverse effects such as pain and inflammation. Its administration is recommended to promote postoperative recovery. More studies are suggested to observe its effects in oral and maxillofacial surgery.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":"30 1","pages":"e124-e128"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between periodontitis and chronic obstructive pulmonary disease: a bibliometric analysis from 1945 to 2023.","authors":"Z Guo, Z Wang","doi":"10.4317/medoral.26582","DOIUrl":"10.4317/medoral.26582","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) and periodontitis are common chronic diseases. The presence of either of the two diseases increases the risk of the other, whereas managing one reduces the risk of the other. This study aimed to summarize the current state of research and trends in this field using bibliometric analysis and visualization.</p><p><strong>Material and methods: </strong>We used PubMed to search and download all periodontal disease- and COPD-related studies published until August 20, 2023. We further performed bibliometric analysis on the text R and Python software and visualized the results using Gephi and VOSviewer to construct latent Dirichlet allocation models that summarize idiosyncratic research themes.</p><p><strong>Results: </strong>A total of 2, 109 publications were analyzed, with recent ones focusing on risk factors and pandemics. The country that produced the most publications was the United States with 427 publications. The most cited article was by Prof. Wang Zuomin. International Journal of Chronic Obstructive Pulmonary Disease ranked first in publications. Keywords were focused on Risk Factors and Pandemics. In addition, COVID-19, SARS-CoV-2 and coronavirus infections have become a research hotspot since 2020. However, little attention has been paid to environmental contamination and biological mechanisms.</p><p><strong>Conclusions: </strong>Research on periodontitis and COPD is expanding, and it currently focused on exploring risk factors and conducting clinical epidemiological studies. This exhaustive study provides a comprehensive summary of trends in this field and has important clinical implications for the screening and treatment of patients with COPD and periodontitis.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e1-e16"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 100 most influential articles in mouth breathing. A bibliometric and altmetric analysis: 2002-2021.","authors":"A-O Campo, P Valderrama, M Bravo, A Baca","doi":"10.4317/medoral.26845","DOIUrl":"10.4317/medoral.26845","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to identify and analyze the most influential Mouth Breathing (MB) articles in children and adolescents with the highest relative citation rates (RCRs), through bibliometric and altmetric analysis, from 2002 to 2021.</p><p><strong>Material and methods: </strong>On March 27, 2023 a PubMed search was conducted to detect papers published about MB. From a total of 826 documents, the article data were downloaded from iCite database. The 100 articles with the highest RCRs were selected for analysis in terms of RCR, citations, altmetric attention score, year, journal, first author (name, institution, country), subfield and design of study. The key words were analyzed using Vosviewer.</p><p><strong>Results: </strong>Among the 100 articles, there were no differences between the two periods analyzed for RCR and AAS values, yet 2002-11 was more cited than 2012-2021. There was no correlation between RCR and AAS; but there was with citations. Brazil was the most cited country (n=30). The articles were published in 48 journals pertaining to 8 categories, 44 corresponding to Dentistry. The most frequent study design was the cross-sectional (n=48). Although all subfields were well represented, the most frequent ones were \"treatment\", \"sleep disorders\" and \"clinical characteristics/cephalometry\". The most prominent keywords were \"malocclusion\" and \"cephalometry\".</p><p><strong>Conclusions: </strong>Using RCR, a time- and field-normalized metric, one can identify influential articles in MB, a multidisciplinary research field of great importance for orthodontics. Because this bibliometric approach reduces the time from publication to the detection of an article´s importance for readers, it could be a valid alternative to using citation counts.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e97-e106"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypovitaminosis D in patients with oral squamous cell carcinoma: Is a risk factor of developing this neoplasia?","authors":"A Maturana-Ramiìrez, J Aitken-Saavedra, G Rojas-Zúñiga, G Rojas-Alcayaga, I Espinoza-Santander, A Rebolledo, R Fuentes, M Reyes-Rojas, C Araya, D Lazo, E Caamaño","doi":"10.4317/medoral.26692","DOIUrl":"10.4317/medoral.26692","url":null,"abstract":"<p><strong>Background: </strong>Hypovitaminosis D raised a significant public health concern due to its potential association with various diseases, including Oral Squamous Cell Carcinoma (OSCC). The objective of this study was to compare serum 25(OH)D3 levels between individuals with and without OSCC, and by subgroups based on their smoking habits.</p><p><strong>Material and methods: </strong>A case-control study was conducted utilizing progressive multicenter recruitment, involving 46 patients with Oral Squamous Cell Carcinoma (OSCC) and 65 controls. Serum levels of 25(OH)D3 were evaluated via electrochemiluminescence. Patients were categorized according to their vitamin D levels into sufficiency, mild deficiency, moderate deficiency, and severe deficiency. Comparative analyses of serum 25(OH)D3 levels were performed between OSCC patients and controls, as well as among subgroups based on their smoking habits. Group comparisons were made with the Mann-Whitney test, and subgroup analyses used the Kruskal-Wallis test. Significance was set at p < 0.05 Results: 91% of participants, including both OSCC patients and controls, exhibited some degree of 25(OH)D3 deficiency. Among them, 71.7% of OSCC patients and 50.7% of controls had serum levels characterized by moderate to severe deficiencies. Patients with OSCC showed lower levels of 25(OH)D3, with medians of 20.2 ng/ml (IQR 9.48), compared to controls, with medians of 24.8 ng/ml (IQR 9.13) (p=0.002). Furthermore, when comparing the medians among the four study groups (smoking and non-smoking controls and smoking and non-smoking patients with OSCC), a significant difference was observed between non-smoking control patients with 25.04 ng/ml (IQR = 9.71) and smoking OSCC patients with 19.65 ng/ml (IQR = 12.14) (p < 0.05).</p><p><strong>Conclusions: </strong>Individuals with oral squamous cell carcinoma (OSCC) exhibited lower serum levels of vitamin D (25(OH)D3) compared to controls, suggesting a potential link between vitamin deficiency and the development of this type of cancer. Vitamin D supplementation could serve as a preventive and therapeutic strategy.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e24-e30"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11801678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}