Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Assessment of the prevalence of Behcet's disease in recurrent aphthous ulceration worldwide: a systematic review.","authors":"A-B Azevêdo, A-P Sobral, C-A Faria, J-S Sousa, W-R Silva, M-M Silveira","doi":"10.4317/medoral.27023","DOIUrl":"10.4317/medoral.27023","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS).</p><p><strong>Material and methods: </strong>A search was performed in Scopus, Medline/PubMed, The Cochrane Library and Web of Science databases, according to PRISMA. In addition, a search was carried out in the DANS Easy Archive to access gray literature and a manual search in the reference list of included studies was used as an additional resource to refine the search. Cross-sectional studies in patients with recurrent aphthous stomatitis evaluating the diagnosis of Behcet's syndrome were analyzed to identify prevalence. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to assess the methodological quality of the articles.</p><p><strong>Results: </strong>The study design, sample size, sex, International Study Group (ISG) diagnostic criteria and prevalence of the syndrome were evaluated. After screening and reading the articles in full, 7 met the inclusion criteria. The articles involved a total of 2841 participants with recurrent aphthous ulcerations, with 141 having a diagnosis of Behcet's syndrome. Studies were of good quality as assessed by the JBI Critical Appraisal Checklist for cross-sectional studies.</p><p><strong>Conclusions: </strong>The prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS) is generally low, with similar frequency in both sexes and more common in the range of countries that extends from the Mediterranean Basin to the Far East.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e484-e490"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferior alveolar nerve damage related to dental implant placement. A systematic review and meta-analysis.","authors":"J-F Peña-Cardelles, J Markovic, S Akhondi, I Pedrinaci, A Lanis, G-O Gallucci","doi":"10.4317/medoral.27125","DOIUrl":"10.4317/medoral.27125","url":null,"abstract":"<p><strong>Background: </strong>A concern associated with implant placement is the potential occurrence of neurovascular lesions and subsequent development of sensory alterations in patients undergoing implant placements. The objective of this review is to evaluate the incidence of neurosensory alterations based on the proximity between the implant and the mandibular canal Material and Methods: A systematic review was conducted in MEDLINE, Web of Science, and Scopus. Studies with common variables were selected to conduct a meta-analysis. The patient classification was based on the mandibular canal-implant distance. Neurosensory alteration percentages were calculated for each study and group.</p><p><strong>Results: </strong>The findings indicate significant correlations between implant placement proximity and neurosensory risks. The incidence of neurosensory alterations in patients with implants placed at a distance ≥ 2 mm from the mandibular canal was 0%. Similarly, for distances between 1-2 mm from the mandibular canal, the incidence remained at 0%. However, for implants placed at a distance of 0-1 mm from the mandibular canal, the incidence of neurosensory alterations was 68%. Additionally, patients with implants that intruded into the canal had an incidence of 53% in the development of neurosensorial alterations.</p><p><strong>Conclusions: </strong>A distance of 1 mm from the mandibular canal might be safe. Implants placed at a distance less than 1 mm from the mandibular canal exhibit neurosensory alterations. Clinicians should be aware of the potential risk of nerve injury and adopt appropriate precautions, including meticulous preoperative planning and three-dimensional radiographic images.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e578-e589"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for rehabilitation management with implants in patients with down syndrome: a scoping review.","authors":"J Dethlefs-Canto, S Baeza-Vallejos, D Ormeño-Sepúlveda, A Bustos-Ponce","doi":"10.4317/medoral.27093","DOIUrl":"10.4317/medoral.27093","url":null,"abstract":"<p><strong>Background: </strong>Down Syndrome (DS), caused by an extra chromosome 21, has a prevalence of 24.7 per 10,000 live births in Chile, the highest in Latin America. Individuals with DS commonly present orofacial and dental anomalies, complicating oral health management. Many depend on removable prostheses, which represent challenges in hygiene, handling, and adaptation. Dental implants are a promising alternative, offering improved stability and functionality. However, successful rehabilitation requires addressing specific anatomical, physiological, and behavioral considerations. This scoping review compiles evidence-based strategies to guide implant treatment in this population.</p><p><strong>Material and methods: </strong>Registered on the Open Science Framework (https://osf.io/bstwk/), this review followed the PRISMA-ScR protocol, addressing the question: \"Which are the management strategies and survival rates of dental implants in patients with Down Syndrome?\" Searches were conducted in Pubmed/MEDLINE, Scopus, Science Direct, Web of Science, and Ebsco databases.</p><p><strong>Results: </strong>Of 92 studies identified, 7 met inclusion criteria, encompassing 179 implants in DS patients. Anesthesia type varied based on patient cooperation and procedure complexity: general anesthesia for uncooperative patients, local anesthesia for compliant individuals, and sedation for intermediate cases. Delayed loading (3-12 months) yielded better outcomes than immediate loading. Overdentures with locator or bar systems were effective and easier to maintain, while screw-retained fixed prostheses provided stability but required strict hygiene adherence. Clinical success rates varied, with higher success in simple cases and higher failure rates in studies involving multiple implants.</p><p><strong>Conclusions: </strong>Dental implants, combined with structured behavioral management, improve oral rehabilitation outcomes in DS patients. While sedation or general anesthesia may be required, associated risks must be carefully managed. Delayed implant loading is recommended to minimize osseointegration failures. An interdisciplinary approach, including material selection, caregiver education, and long-term maintenance, is essential for successful, individualized outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e561-e567"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brazilian oral medicine and oral pathology: international scientific collaborations.","authors":"L-M Ferreira, J-P Nascimento, S Trezena, M-P Maia-Lima, L-F Sobral, A-M Alencar, D-R -Martelli, M-A Lopes, F-R Pires, H Martelli-Júnior","doi":"10.4317/medoral.27169","DOIUrl":"10.4317/medoral.27169","url":null,"abstract":"<p><strong>Background: </strong>Research in Oral Medicine (OM) and Oral Pathology (OP) in Brazil has experienced remarkable growth, gaining international recognition. However, no analysis has evaluated the patterns of evolution of international partnerships and their role in advancing Brazilian research in these areas. This study analyzed collaborations between Brazilian and international researchers in OP/OM.</p><p><strong>Material and methods: </strong>A bibliometric cross-sectional survey was conducted using data from Brazilian researchers in OP/OM, identified through the Brazilian Society of Stomatology and Maxillofacial Pathology. Researchers' curriculum on the Lattes platform were analyzed, and data on publications, citations, co-authorships, affiliations, and journals were collected from the Scopus database, focusing on international collaborations. Bibliometric analyses were performed using the Bibliometrix tool in R Studio and VOSviewer software. Statistical trends between decades were compared using the Kruskal-Wallis test.</p><p><strong>Results: </strong>The sample included 229 researchers, most females (61.6%), affiliated with public institutions (78.9%), and with a mean time since achieving the PhD of 15.27 years. Almost half of the researchers (43.2%) had postdoctoral training, and among them 43.4% completed it abroad, mainly in the United States (USA), Canada, and the United Kingdom (UK). A total of 2,027 articles were analyzed, revealing a 10.53% annual growth in publications. The number of international collaborations significantly increased over decades (p < 0.001), with USA, UK, India, and Italy being the leading partners. Collaborative publications showed a significant rise in citations (42.61 per paper), mainly in high-impact journals.</p><p><strong>Conclusions: </strong>A steady increase in international collaborations in OP/OM was identified, especially with the USA and the UK. These partnerships have increased citations and publications in high-impact journals, which highlights their benefit and importance for research in these areas.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e605-e613"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of removing the fracture fragments in the treatment of intracapsular condylar fractures in children.","authors":"J Dai, C Gong, D Diarra, Z Li","doi":"10.4317/medoral.27079","DOIUrl":"10.4317/medoral.27079","url":null,"abstract":"<p><strong>Background: </strong>Treatment methods for mandibular condylar fractures in children can be broadly divided into closed treatment and open treatment (open reduction and internal fixation). The aim of the study is to evaluate the feasibility of removing the fracture fragments when treating intracapsular condylar fractures in children.</p><p><strong>Material and methods: </strong>A retrospective study was performed in patients aged ≤12 years with intracapsular condylar fractures treated with removal of the fracture fragments from June 2010 through June 2018. The preoperative and postoperative data of physical complaints, facial asymmetry, maximal interincisal distance, occlusal relationship and radiographic examinations were extracted from the patients' records. The collected preoperative and postoperative data were analysed.</p><p><strong>Results: </strong>Thirteen intracapsular condylar fractures in nine cases were subjected to fracture fragments removal. In these patients, clinical and radiographic results at different follow-up periods displayed normal occlusion and satisfactory bone healing. New condyles were found to be regenerated, in the cases with follow-up period longer than 3 months.</p><p><strong>Conclusions: </strong>Removal of fracture fragments proves to be effective in delivering satisfactory clinical results and permitting ongoing condyle remodelling and regeneration.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e536-e542"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the use of proton pump inhibitors lead to an increased risk of dental implant failure? A systematic review and meta-analysis.","authors":"M Tang, Z Xie","doi":"10.4317/medoral.27043","DOIUrl":"10.4317/medoral.27043","url":null,"abstract":"<p><strong>Background: </strong>Proton-pump inhibitors (PPI) are one of the commonly used medications for a variety of gastrointestinal disorders. Given the large population using PPI and the increased use of dental implants in recent times, it is pertinent to examine if PPI impacts implant outcomes. This systematic review examined the risk of implant failure amongst PPI users vs non-users.</p><p><strong>Material and methods: </strong>PubMed, Embase, Scopus, and Web of Science literature databases were scouted for cohort or case-control studies comparing implant survival between PPI users vs non-users. Last date of the literature search was 30th October 2024.</p><p><strong>Results: </strong>We identified eight studies for inclusion. Both crude and adjusted data were pooled separately. Meta-analysis of crude data demonstrated that there was a statistically significant risk of implant failure in PPI users as compared to non-users (OR: 2.71 95% CI: 1.72, 4.29 I2 = 63%). These results failed to change on sensitivity analysis. Pooled analysis of adjusted data showed that PPI use may not independently predict implant failure (OR: 1.44 95% CI: 0.92, 2.24 I2 = 73%). Exclusion of one outlier study showed a significantly increased risk of implant failure with PPI use (OR: 1.71 95% CI: 1.17, 2.50 I2 = 42%).</p><p><strong>Conclusions: </strong>There may be a tendency for higher implant failure in patients using PPI. The lack of stability of the results on sensitivity analysis and non-significant associations noted with adjusted data preclude strong conclusions. There is a need for further high-quality studies to strengthen the available evidence.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e512-e519"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of shape and thickness variations in patient-specific implants for t-shaped genioplasty.","authors":"E-F Akkoyun, T Pergel","doi":"10.4317/medoral.27065","DOIUrl":"10.4317/medoral.27065","url":null,"abstract":"<p><strong>Background: </strong>T-shaped genioplasty is a versatile surgical technique used to correct chin deformities by altering its vertical, transverse, and sagittal dimensions. Despite numerous advancements in patient-specific implants (PSIs), the biomechanical impact of PSI thickness and the number of screws used for fixation remain unexplored. This study aims to evaluate the effects of PSI thickness and screw configurations on fixation stability in T-shaped genioplasty using finite element analysis.</p><p><strong>Material and methods: </strong>Mandibular computed tomography data were used to construct 12 three-dimensional models with varying PSI thicknesses (0.6 mm, 0.9 mm, and 1.2 mm) and screw configurations (five, six, seven, and eight screws). T-shaped osteotomies were applied to create narrowing and widening genioplasty models, with iliac bone grafts placed in widening scenarios. Horizontal forces of 50 N were applied bilaterally, and fixation stability was evaluated using von Mises stress and bone displacement. Fixation was considered stable when bone displacement amounts were below 1 mm.</p><p><strong>Results: </strong>In narrowing models, fixation stability was achieved with five screws and a 1.2 mm PSI or seven screws with a 0.9 mm or 1.2 mm PSI, showing stress values within titanium's yield strength limits. For widening models, stable fixation was achieved with six screws and a 0.9 mm or 1.2 mm PSI, or eight screws across all tested thicknesses. Bone displacement was minimal with thicker PSIs and higher screw counts, demonstrating improved stability.</p><p><strong>Conclusions: </strong>This study highlights the importance of PSI customization in optimizing fixation stability in T-shaped genioplasty. A minimum of five screws with a 1.2 mm plate or seven screws with a 0.9 mm plate is suggested for narrowing, while six screws with a 0.9 mm plate or eight screws with any tested thickness are sufficient for widening. Future research should address combined movements, dynamic loading, and long-term outcomes to refine PSI fixation strategies further.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e528-e535"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates.","authors":"G-V Fernandes, B-G Martins, A Heboyan, R-M Castilho, J-C Fernandes","doi":"10.4317/medoral.27033","DOIUrl":"10.4317/medoral.27033","url":null,"abstract":"<p><strong>Background: </strong>The primary goal of this in vivo study was to ascertain if systemic bisphosphonates (BPs) positively affect bone repair in non-critical defects when assisted with a carbonated hydroxyapatite graft biomaterial (Biomat).</p><p><strong>Material and methods: </strong>Thirty-six female rats were allocated into two control groups (blood clot [BC] and alloplastic biomaterial); two groups with zoledronate (third-generation BPs): Zol.BP and Zol.BP+Biomat; and two groups with clodronate (first-generation BPs): Clod.BP and the Clod.BP+Biomat. The experimental groups started the application of BP 60 days before surgery. Then, a 2 mm non-critical defect was performed in the rats' femur and filled according to the group. All animals were euthanized 30 days after surgery, and the samples were collected for histological and histomorphometry analysis, respectively, for descriptive and quantitative analyses.</p><p><strong>Results: </strong>Zol.BP+Biomat had greater new bone formation, whereas clodronate presented high osteogenic potential, significantly increasing the observed levels of newly formed bone even in the absence of the biomaterial. Histomorphometrically, BC had 2% bone formation compared to the biomaterial group (5%). Zol.BP and Col.BP achieved bone formation of 6-fold (12%, p>0.05) and 9.5-fold (19%, p<0.05), respectively, when compared with BC. Zol.BP+Biomat group presented the highest value found for newly formed bone (24%), 12-fold more than BC (p<0.001) and 4.8-fold more than the biomaterial group (p<0.01).</p><p><strong>Conclusions: </strong>It is possible to conclude that the systemic use of BP positively affected non-critical bone defects when associated with biomaterials, mainly when the third generation of BPs was used in this association.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e491-e498"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials.","authors":"C-M Mesquita, A-C Diniz, S-P Sakamoto, W-A Vieira, R-B Brito-Junior, M-D Costa, L-R Paranhos","doi":"10.4317/medoral.27260","DOIUrl":"https://doi.org/10.4317/medoral.27260","url":null,"abstract":"<p><strong>Background: </strong>Orthognathic surgery is a complex invasive procedure associated with common postoperative symptoms and patient-related events. Dexmedetomidine is an emerging sedative and hypotensive agent that has demonstrated safety and efficacy in perioperative care of other craniofacial procedures.</p><p><strong>Material and methods: </strong>An electronic search was performed in seven primary databases (Cochrane Library, Embase, LILACS, MedLine via PubMed, SciELO, Scopus, and Web of Science) and one additional (EASY) to partially capture the gray literature. The PICO strategy was used to identify randomized clinical trials evaluating the effect of dexmedetomidine on perioperative events in patients undergoing orthognathic surgery compared to placebo or control groups, without restrictions on publication language and year. Two independent reviewers performed data extraction and assessed the risk of bias using the RoB 2.0 tool.</p><p><strong>Results: </strong>The search identified 401 records, of which six studies met the eligibility criteria, including 282 patients from five countries, and published between 2008 and 2023. Outcomes were categorized into six groups based on available data: 1) Airway and Respiratory Events, 2) Emetic Events, 3) Hemodynamic Events, 4) Length of Hospital Stay, 5) Neurological Events, and 6) Pain Burden. Dexmedetomidine reduced coughing and maintained hemodynamic stability but did not prevent emergence agitation. It was associated with lower intraoperative fentanyl use and reduced rescue analgesia requirements. Postoperatively, dexmedetomidine effectively controlled pain, nausea, and vomiting, with significantly lower pain scores and reduced analgesic demand. Among the six studies, only one was classified as high risk of bias due to issues in the randomization process, while the others were categorized as low risk of bias. A meta-analysis was planned but could not be conducted due to high heterogeneity among studies.</p><p><strong>Conclusions: </strong>Dexmedetomidine appears to be a safe and effective option for reducing postoperative symptoms such as pain, nausea, vomiting, and cough in orthognathic surgery, while maintaining hemodynamic stability.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of leukocyte- and platelet-rich fibrin in the treatment and prevention of medication-related osteonecrosis of the jaw: a prospective study.","authors":"A Medeiros-Monzón, A Blanco-Carrión, P Gándara-Vila, G-C Camolesi, A Pérez-Jardón, A-I Lorenzo-Pouso, M Pérez-Sayáns","doi":"10.4317/medoral.27249","DOIUrl":"https://doi.org/10.4317/medoral.27249","url":null,"abstract":"<p><strong>Introduction: </strong>Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition associated with bone modifying agents (BMAs) intake, leading to impaired bone healing and increased morbidity. Despite various therapeutic approaches, an optimal treatment strategy remains elusive. Leukocyte- and Platelet- Rich fibrin (L-PRF) has emerged as a promising autologous biomaterial due to its regenerative properties. This study aimed to evaluate the efficacy of L-PRF in the treatment and prevention of MRONJ.</p><p><strong>Material and methods: </strong>A prospective cohort study was conducted, including a total of 30 patients diagnosed with MRONJ (stage I or II) or at risk of developing it (non-MRONJ). Patient underwent standardized treatment involving surgical debridement followed by L-PRF application. Clinical and demographic data were collected, and healing outcomes were assessed at multiple follow-up intervals (7 days, 14 days, 1 month, 3 months and 6 months). Statistical analyses, including Kaplan-Meier survival estimates, were performed to evaluate treatment effectiveness.</p><p><strong>Results: </strong>The study demonstrated an overall healing of 90%, with a complete recovery in 82.4% of confirmed MRONJ cases and 100% of at-risk patients. L-PRF exhibited good clinical outcomes, including reduced inflammation and pain, accelerated epithelialization, and improved tissue regeneration. The median healing time was estimated at 33.41 days for MRONJ patients and 11.00 for non-MRONJ. No significant differences in healing rates were observed based on age, sex, or systemic conditions.</p><p><strong>Conclusions: </strong>L-PRF represents a promising adjunct in MRONJ management, improving healing outcomes and postoperative recovery. Its autologous nature and growth factor release enhance bone regeneration, suggesting its potential as both a therapeutic and preventive strategy. Further larger-scale clinical trials are needed to standardize protocols and validate long-term efficacy.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}