Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Impact of risk factors in craniofacial mucormycosis.","authors":"J-A Morales-Del Angel, A-S Guerra-Garza, J-E Juárez-Silva, S-M Macias-Alfaro, B González-Andrade, M-A Sánchez-Corella, J-L Treviño-González","doi":"10.4317/medoral.26789","DOIUrl":"10.4317/medoral.26789","url":null,"abstract":"<p><strong>Background: </strong> Craniofacial mucormycosis is a highly lethal infectious disease. This study aims to assess and analyze multiple variables, including clinical, socioeconomic, and biochemical markers, to identify and examine risk factors for mortality associated with this mycotic infection.</p><p><strong>Material and methods: </strong> A retrospective analysis was conducted on 38 patients who sought medical attention at the Otolaryngology and Head and Neck Surgery Division of a tertiary-level hospital in Monterrey, Mexico. A broad range of variables was analyzed: clinical features, including the extent of mucormycosis infection; socioeconomic factors such as monthly income, marital status, geographical residence, educational level, and insurance status; as well as biochemical markers, including glucose levels, lactate dehydrogenase (LDH), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and immune cell counts, specifically neutrophils (NEU) and lymphocytes (LYM). Statistical analysis was conducted using SPSS v26. Risk factors for mortality were evaluated using Cox regression. Overall survival (OS) was assessed with the Kaplan-Meier method. The Fisher's exact test and the Chi-square test were used for categorical variables. For median comparisons, the Student's t-test and Mann-Whitney U test were applied; with normality assessed using the Shapiro-Wilk test. A p-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong> Mucormycosis was associated with higher mortality in men (p=0.032). The disease primarily affected the paranasal sinuses (p=0.021) and was associated with increased mortality when involving the orbit (p=0.035). Additionally, compromised lymphocyte counts (LYM) (p=0.034) and lower educational levels (p=0.009) were associated with higher mortality. Individuals residing in rural areas also exhibited an elevated risk of mortality (p =0.023).</p><p><strong>Conclusions: </strong> Prevention strategies should focus on high-risk groups to reduce the mortality rate of craniofacial mucormycosis, particularly targeting men and individuals residing in rural areas. Special emphasis should be placed on those without education or health insurance. Early diagnosis and appropriate management are crucial for improving outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e211-e216"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life in primary Sjögren's Syndrome.","authors":"L Ingolotti, M Bejarano, N Tamborenea, A Mercé, C Arguissain, L Martin, J Morbiducci, V Azcona, L Teplizky, E Casals, A Hernandez, M Marseillan, A Secco","doi":"10.4317/medoral.26934","DOIUrl":"10.4317/medoral.26934","url":null,"abstract":"<p><strong>Background: </strong>Primary Sjögren Syndrome (pSS) is an autoimmune disease that usually affects salivary glands. Research about the impact of oral health in quality of life of patients with pSS is scarce.</p><p><strong>Objectives: </strong>to describe the characteristics of oral involvement in patients with pSS; To assess quality of life related to oral health (QOL-OH); to determine association between QOL-OH and saliva production, disease activity, and damage.</p><p><strong>Material and methods: </strong>An observational, analytical and cross-sectional study was conducted. Patients aged ≥18 years with pSS were included. Primary outcome was assessed by the Oral Health Impact Profile (OHIP14sp). The EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), the EULAR Sjögren's syndrome Disease Activity Index (ESSDAI), the Sjogren's Syndrome Damage Index (SSDI) and a Visual Analogue Scale (VAS) for xerostomia, were performed. A dentist evaluated the Decayed, Missing, and Filled Permanent Teeth index (DMFT), O'Leary index (OLI) and Loe & Silnes index (LSI). A multiple linear regression model was performed, taking OHIP14sp as the dependent variable.</p><p><strong>Results: </strong>51 patients were included. Mean age 54 (±13 years). The OHIP-14sp median was 16 [6-25], xerostomia VAS median was 60 [30-80]. Mean of ESSPRI: 4 (± 2.6), ESSDAI median: 0 [0-2], SSDDI median: 3 [2-4]. Oral involvement occurred in 100% of patients, DMFT median: 22 [14-28], OLI median: 21[13-30]. In the univariate analysis, OHIP14sp was significantly associated with ESSPRI (β2 95%CI 0.72-3.3), xerostomia VAS (β0.19 95%CI 0.08-0.29) and category 2 of the LSI (β: 18 95% CI: 5-31). In the multivariate analysis, OHIP14sp was independently and significantly associated with xerostomia VAS (β0.19 95%CI 0.09-0.29) and category 2 of LSI (β19 95% CI: 7.7-29.7).</p><p><strong>Conclusions: </strong>These findings demonstrate the effects of xerostomia on daily life of patients influencing not only their oral health but also their quality of life.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e265-e270"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Certainty of evidence on the effects of cryotherapy, surgical wound closure, and chlorhexidine on clinical and patient-centered outcomes after third molar surgery: evidence mapping of systematic reviews and meta-analyses.","authors":"E-M Nascimento-Júnior, F-W Costa, P-R Martins-Filho","doi":"10.4317/medoral.26788","DOIUrl":"10.4317/medoral.26788","url":null,"abstract":"<p><strong>Background: </strong>Removal of third molars often leads to complications such as pain, swelling, and trismus, impacting patient quality of life. Various strategies including cryotherapy, different suture techniques, and chlorhexidine are employed to mitigate these effects. However, the effectiveness of these interventions is still debated, as clinical trials present inconsistent and contrasting results. This study aims to assess the certainty of evidence from systematic reviews and meta-analyses regarding the effects of these interventions on clinical outcomes and patient quality of life following third molar surgery.</p><p><strong>Material and methods: </strong>This evidence mapping followed the Global Evidence Mapping Initiative and PRISMA guidelines, utilizing databases such as PubMed, Embase, Cochrane, Web of Science, and Google Scholar until February 2024. Methodological quality was assessed via AMSTAR-2 and the effects of these interventions on outcomes of interest were classified as \"beneficial\", \"probably beneficial\", \"harmful\", \"no effect\", or \"inconclusive\". Findings were mapped using the PyMeta platform.</p><p><strong>Results: </strong>Thirteen studies were reviewed. All systematic reviews evaluated the effects of these interventions on clinical outcomes following third molar surgery, but none assessed the impact on patient quality of life. Cryotherapy was classified as probably beneficial for reducing pain and swelling within the first 72 hours post-surgery. Secondary surgical wound closure was effective in reducing pain, swelling, and trismus during the first postoperative week, but it did not mitigate the risk of bleeding, infection, or alveolitis. Chlorhexidine, especially when used as a mouthwash, is effective in preventing postoperative alveolitis. However, most reviews (76.9%) were rated as \"critically low\" methodological quality.</p><p><strong>Conclusions: </strong>Although the potential benefits of cryotherapy, secondary surgical wound closure, and chlorhexidine on clinical outcomes, this study revealed a predominantly low quality of evidence from systematic reviews and meta-analyses. Moreover, further research should expand investigations into the patient-centered outcomes to better guide clinical practice.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e199-e210"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ozone therapy on postoperative pain, swelling, and trismus caused by surgical extraction of unerupted lower third molars: a double-blinded split-mouth randomized controlled trial.","authors":"R-B Almeida, F-U Campos, J-C Ramacciato, D-C Peruzzo, G-V Fernandes, J-C Joly, M Sperandio","doi":"10.4317/medoral.26974","DOIUrl":"https://doi.org/10.4317/medoral.26974","url":null,"abstract":"<p><strong>Background: </strong>Third molar extraction surgery is a common procedure, but it results in pain, swelling, and trismus. Ozone therapy (Oz) has emerged as a viable option for pain control and as an option to limit bacterial growth, improving the wound healing. Then, this randomized controlled trial aimed to evaluate the effectiveness of adjunctive use of ozone therapy (OzT) in managing pain, swelling, and trismus after lower third molar removal.</p><p><strong>Material and methods: </strong>A split-mouth design was selected, enrolling 60 patients. There were 2 groups (Sham and OzT). The same surgeon performed all procedures. The pain was evaluated using the VAS scale and the number of paracetamol tablets taken. The quality of life was assessed using the OHIP-14 questionnaire. The data were statistically evaluated.</p><p><strong>Results: </strong>120 surgical procedures were performed on 60 participants (34 males [56%] and 26 females [44%]). Regarding the number of paracetamol tablets taken, the test group had a significantly lower consumption (p<0.002). In addition, the test group presented a significantly lower pain score on days 1, 3, and 5 postoperatively, with no difference between groups on the 7th day (p<0.0145). Both sides presented postoperative edema, which regressed from day 5 (no significant difference). A similar case scenario was observed for mouth opening. OzT impacted the patient's quality of life (OHIP-14, p<0.05), favoring ozone therapy.</p><p><strong>Conclusions: </strong>The results demonstrated that OzT is an effective adjunctive strategy for reducing postoperative pain following the extraction of lower third molar teeth.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between prediabetes and periodontitis: a meta-analysis of observational studies with multivariate analysis.","authors":"Y Zhou, F Sun, Q Zhu","doi":"10.4317/medoral.26961","DOIUrl":"https://doi.org/10.4317/medoral.26961","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence suggests that prediabetes may increase the risk of periodontitis, though the extent of this association remains unclear. To provide a clearer understanding, this meta-analysis focused on observational studies that utilized multivariate analyses to adjust for key confounding factors.</p><p><strong>Material and methods: </strong>A comprehensive search of PubMed, Embase, and Web of Science was conducted to identify observational studies assessing the relationship between prediabetes and periodontitis. Only studies that utilized multivariate analyses were included to minimize confounding bias. The quality of the studies was evaluated with the Newcastle-Ottawa Scale (NOS). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model, with heterogeneity assessed by the I² statistic.</p><p><strong>Results: </strong>Ten observational studies with 38,727 participants were included. Overall, individuals with prediabetes had a significantly higher risk of periodontitis compared to normoglycemic individuals (OR: 1.27, 95% CI: 1.09 to 1.48, p < 0.001) with moderate heterogeneity (I² = 53%). Subgroup analyses revealed a stronger association in studies where the proportion of men was < 45% compared to those ≥ 45% (OR: 1.75 vs. 1.15, p for subgroup difference = 0.01). Studies with lower quality (NOS score = 7) showed a stronger association compared to higher-quality studies (NOS score = 8 or 9, p for subgroup difference = 0.003).</p><p><strong>Conclusion: </strong>This meta-analysis found that prediabetes may be independently associated with an increased risk of periodontitis. Further research is needed to explore the mechanisms underlying this association and potential sex-specific effects.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral side effects of fluoxetine in patients with depressive disorder: A systematic review.","authors":"M-G Sarrión Pérez, Y Jiménez, L Bagan, J Bagan","doi":"10.4317/medoral.26947","DOIUrl":"10.4317/medoral.26947","url":null,"abstract":"<p><strong>Background: </strong>Selective serotonin reuptake inhibitors are currently the preferred drugs for treating depression, a condition that has become more prevalent in recent years. Fluoxetine is one of the most widely used, but, like other antidepressants, it can cause several systemic and oral adverse effects. This systematic review aimed to analyze the frequency of oral adverse effects of fluoxetine in comparison to other antidepressants.</p><p><strong>Material and methods: </strong>A systematic review was conducted following PRISMA guidelines. A comprehensive literature search was performed in MEDLINE via PubMed, Scopus, The Cochrane Library, and Web of Science, with no date restrictions, including randomized clinical trials and observational studies. The risk of bias was assessed using the Revised Cochrane Risk-of-Bias Tool for randomized trials.</p><p><strong>Results: </strong>A total of 333 articles were identified. After removing duplicates and applying inclusion criteria, 31 randomized clinical trials were selected for analysis. Fluoxetine was primarily compared with tricyclic antidepressants, SSRIs, serotonin-norepinephrine reuptake inhibitors, and other antidepressants. The most frequently reported oral side effect was dry mouth, with prevalence rates ranging from 2.71% to 52.17%, though it was generally lower than with other antidepressants. Dysgeusia was less frequently reported, with only two studies documenting taste alterations. Oral side effects were primarily assessed through subjective patient reports, and no studies incorporated objective salivary flow measurements. Other adverse effects, such as nausea and vomiting, were commonly mentioned, but their potential oral consequences were not evaluated.</p><p><strong>Conclusions: </strong>Fluoxetine is associated with oral side effects, with dry mouth being the most frequently reported. However, data on dysgeusia remain limited, highlighting the need for further research to determine its prevalence. Given the potential impact of dry mouth on oral health and quality of life, future studies should incorporate objective salivary measurements and further investigate the clinical implications of these adverse effects.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimensional changes in buccal cortical bone and lesion volume in teeth with persistent chronic periapical disease subjected to periapical surgery: a cone beam computed tomography study at one year of follow-up.","authors":"A Boronat-López, J-C Bernabeu-Mira, M Peñarrocha-Diago, M Peñarrocha-Diago, D Peñarrocha-Oltra","doi":"10.4317/medoral.27006","DOIUrl":"https://doi.org/10.4317/medoral.27006","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate changes in buccal cortical bone and lesion volume in teeth with persistent periapical disease one year after periapical surgery using cone-beam computed tomography (CBCT).</p><p><strong>Material and methods: </strong>A prospective study was conducted involving patients with persistent periapical disease undergoing periapical surgery, with one year of follow-up. Data collected included patient age, gender, teeth involved, and the number of roots/lesions. CBCT measurements were taken preoperatively and one year post-surgery, including the distance from the cementoenamel junction to the buccal bone crest (CEJ-BBC), marginal bone loss, buccal cortical height, presence of fenestration, apical depth, cortical bone width at 1, 3, and 5 mm from the buccal bone crest, and lesion volume in mm³. Success was assessed using the \"Modified Penn 3D criteria.\"</p><p><strong>Results: </strong>The study included 92 patients with 111 roots exhibiting persistent chronic periapical lesions. Statistically significant changes were observed in all buccal cortical bone parameters one year after surgery. The CEJ-BBC distance increased, indicating a marginal bone loss of 0.23 mm. Notably, the height from the buccal cortical bone crest to the lesion, apical depth, buccal bone thickness, the number of fenestrations, and lesion volume decreased (91.1%). Buccal cortical bone thickness was a predictor of volume reduction, showing a significant relationship at T1 between greater thickness and smaller volume variation. Patient age and gender did not significantly influence these changes. Fenestrations and larger lesion volumes correlated with reduced healing probabilities. The overall success rate was 88%, with tooth position and root involvement impacting healing outcomes.</p><p><strong>Conclusions: </strong>One year post-surgery, buccal cortical bone showed no clinically relevant changes, while lesion volume decreased by 91.1%, more significantly in anterior teeth. Greater buccal cortical bone width was associated with smaller volume reduction. A larger lesion volume and presence of fenestrations adversely affected healing rates.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of removing the fracture fragments in the treatment of intracapsular condylar fractures in children.","authors":"J Dai, C Gong, D Diarra, Z Li","doi":"10.4317/medoral.27079","DOIUrl":"https://doi.org/10.4317/medoral.27079","url":null,"abstract":"<p><strong>Background: </strong>Treatment methods for mandibular condylar fractures in children can be broadly divided into closed treatment and open treatment (open reduction and internal fixation). The aim of the study is to evaluate the feasibility of removing the fracture fragments when treating intracapsular condylar fractures in children.</p><p><strong>Material and methods: </strong>A retrospective study was performed in patients aged ≤12 years with intracapsular condylar fractures treated with removal of the fracture fragments from June 2010 through June 2018. The preoperative and postoperative data of physical complaints, facial asymmetry, maximal interincisal distance, occlusal relationship and radiographic examinations were extracted from the patients' records. The collected preoperative and postoperative data were analysed.</p><p><strong>Results: </strong>Thirteen intracapsular condylar fractures in nine cases were subjected to fracture fragments removal. In these patients, clinical and radiographic results at different follow-up periods displayed normal occlusion and satisfactory bone healing. New condyles were found to be regenerated, in the cases with follow-up period longer than 3 months.</p><p><strong>Conclusions: </strong>Removal of fracture fragments proves to be effective in delivering satisfactory clinical results and permitting ongoing condyle remodelling and regeneration.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction between third molars and surrounding periapical tissues in mandibular stress distribution during high-impact trauma: a finite element study.","authors":"C-B Nogueira, F-W Costa, F-S Carvalho, T-P Bezerra, I-C Neto, F-I Júnior, E-C Soares","doi":"10.4317/medoral.26954","DOIUrl":"https://doi.org/10.4317/medoral.26954","url":null,"abstract":"<p><strong>Background: </strong>The presence of mandibular third molars has been associated with the risk of mandibular fractures, highlighting the need for comprehensive studies considering the interaction with other mandibular structures. This study investigates how mandibular third molars and neighboring tissues can influence the structural fragility of the mandible using finite element analysis.</p><p><strong>Material and methods: </strong>A finite element analysis study following the guidelines proposed by RIFEM 1.0 was performed using three previously created mandible models: Model A, without right and left third molars; Model B, without one third molar; Model C, with bilateral presence of third molars. A 2452N force was applied to the right mandibular body in a virtual environment, allowing for a structural analysis of each mandible.</p><p><strong>Results: </strong>Models without third molars and with only one third molar showed similar energy dissipation patterns, contrasting with the model with both third molars. The presence of third molars influenced the magnitude and distribution of stress, highlighting fragility points in specific areas such as the lingual surface, the condyles bilaterally (models without and with one contralateral third molar to trauma), and the distal cervical region of the second molar (third molar absent), as well as significantly showed the path of energy towards the contralateral side of the trauma with a concentration of energy at the contact points of virtually all teeth present immediately after impact.</p><p><strong>Conclusions: </strong>The presence of mandibular third molars influenced the distribution and magnitude of stress within the mandible during a simulated high-impact trauma. Models with third molars exhibit distinct stress patterns, with fragility points appearing in critical areas such as the lingual surface, condyles, and second molar regions. These findings suggest that the presence of third molars increases the structural fragility of the mandible, potentially elevating the risk of mandibular fractures, especially in the context of traumatic impacts.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of knowledge of the relationship between celiac disease and oral pathology: A scoping review.","authors":"R Martín-Masot, P Ramos-García, E Torcuato-Rubio, M-I Pérez-Gaspar, V-M Navas-López, M-Á González-Moles, T Nestares","doi":"10.4317/medoral.26950","DOIUrl":"https://doi.org/10.4317/medoral.26950","url":null,"abstract":"<p><strong>Background: </strong>Celiac disease (CD) is a systemic disorder characterized by an enteropathy of highly variable clinical expression, in which the relationship with oral pathology has not yet been fully elucidated. We aimed to update the current knowledge on oral manifestations in CD, to identify evidence gaps and to point out future research lines.</p><p><strong>Material and methods: </strong>PRISMA-ScR guidelines were followed. MEDLINE/PubMed, Embase, Web of Science and Scopus were searched for primary-level observational studies to analyze the prevalence of oral pathology in CD patients, without language or publication date restrictions.</p><p><strong>Results: </strong>We included 107 studies, encompassing a total of 26148 celiac patients and 36063 controls. Our results point to several oral pathologies with higher prevalence in CD patients than in healthy controls, most notably recurrent aphthous stomatitis (RAS)(n=69 studies/12606 celiac patients), developmental enamel defects (n=61 studies/5037 patients), dental caries (n=33 studies/2730 patients), delayed eruption (n=12 studies/1062 patients), atrophic glossitis (n=10 studies/1062 patients), angular cheilitis (n=7 studies/10606 patients), gingivo-periodontal diseases (n=7 studies/1122 patients), and Sjögren's syndrome (n=5 studies/953 patients).</p><p><strong>Conclusions: </strong>CD is frequently associated with oral pathologies, including RAS, dental caries, gingivitis, decreased salivary flow, dental enamel defects and some relevant autoimmune processes, such as oral lichen planus and probably Sjögren's syndrome.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}