Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Tooth regeneration in animals. A systematic review.","authors":"J Bartolomé-Lechuga, L Hernando-Calzado, C-M Cobo-Vázquez, J Sanz-Alonso, J López-Quiles, C Madrigal-Martínez-Pereda","doi":"10.4317/medoral.27269","DOIUrl":"https://doi.org/10.4317/medoral.27269","url":null,"abstract":"<p><strong>Background: </strong>Methods for creating bioengineered replacement teeth benefit from a detailed understanding of the molecular signaling networks that regulate the development of natural teeth. In oral and craniofacial research, spheroid cultures have been explored, various studies on organoids, such as those of salivary glands, taste buds, and teeth, are being conducted. The aim of this review is to provide a comprehensive overview of the current knowledge on dental regeneration.</p><p><strong>Material and methods: </strong>This review was registered in PROSPERO (CRD 646053) ad performed following PRISMA guidelines. An electronic search was conducted following the PICO question \"In animals (P) subjected to bioengineering techniques (I), is successful dental regeneration achieved (O)?\" For evaluating risk of bias, the Arrive scale and the JBI adapted for Quasi-experimental studies tools were used.</p><p><strong>Results: </strong>A total of 83 articles on dental regeneration from the past 5 years were reviewed, and 4 articles that met the selection criteria were included. The studies describe complete dental regeneration in animal models by stimulating genes such as Wnt10a, Bmp6, Grem2a and the identification of genes and antibodies influencing BMP and Wnt signaling pathways (Sox-2), as well as the expression of key factors such as FGF.</p><p><strong>Conclusions: </strong>The development of signaling pathways in dental formation has advanced, yet many uncertainties persist, particularly in the regeneration of complete teeth. Despite progress with animal models and genetic editing, identifying suitable cellular sources and understanding the key genes involved remain essential for future clinical applications.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring potential salivary biomarkers for dental caries: a systematic review.","authors":"M López-Galindo, W Atashkadeh","doi":"10.4317/medoral.27329","DOIUrl":"https://doi.org/10.4317/medoral.27329","url":null,"abstract":"<p><strong>Background: </strong>Dental caries remains one of the most widespread non-communicable diseases. Saliva is crucial for maintaining oral health as it shields teeth from demineralization and promotes the remineralization of enamel. Although ongoing studies are investigating the relationship between various salivary proteins and dental caries, consensus in existing literature has not yet been established. This study aims to provide additional insights into the current research of salivary protein biomarkers association with dental caries.</p><p><strong>Material and methods: </strong>This systematic review analyzed literature published between January 2013 to December 2023, retrieved from PubMed, Scopus, and Web of Science.</p><p><strong>Results: </strong>The review included 21 observational studies (2 cohort, 2 case-control, and 17 cross-sectional) involving over 2,000 participants, examining 18 different proteins. There was considerable variability in the types of salivary markers studied. Among the participants, 54% were diagnosed as caries-active (CA), while 45.9% were caries-free (CF), with ages ranging from 6 to 89 years. The Newcastle-Ottawa Scale indicated that the risk of bias was low in 10 studies, intermediate in 10, and high in 1.</p><p><strong>Conclusions: </strong>Eighteen studies found significant differences in protein expression between CA and CF subjects, underscoring the potential of using salivary biomarkers for non-invasive diagnose assessment. However, larger and greater designed studies are needed to establish their clinical value. Besides, divergent results from proteomic studies on biomarkers may be due to variations in genetics, diet, oral hygiene, age and other factors of the subjects, which could affect the reliability of saliva biomarkers in caries screening and detection. The significant heterogeneity among studies made conducting a proper meta-analysis infeasible.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases.","authors":"P Sole, P Tapia, S Mordoh, M Carvajal, G Matus-Miranda, B Ossandón-Zuñiga","doi":"10.4317/medoral.27519","DOIUrl":"https://doi.org/10.4317/medoral.27519","url":null,"abstract":"<p><strong>Background: </strong>Maxillofacial infections (MIs), particularly surgical site infections (SSIs) following orthognathic surgery, represent a significant clinical concern due to their potential severity and impact on treatment outcomes. Although antibiotic prophylaxis is standard practice, growing bacterial resistance-especially in penicillin-allergic patients-challenges the effectiveness of alternative regimens such as clindamycin.</p><p><strong>Material and methods: </strong>This retrospective study analyzed 100 consecutive patients who underwent orthognathic surgery between 2022 and 2023, performed by the same surgical team. All patients received standardized perioperative care, including hospitalization and intravenous (IV) antibiotic prophylaxis with cefazolin or clindamycin for those allergic to penicillin. The incidence of SSIs was evaluated and correlated with the type of antibiotic used. Microbial cultures and antibiograms were obtained from infected cases requiring surgical wound revision.</p><p><strong>Results: </strong>Of the 100 patients, 98 received prophylactic cefazolin and showed no SSIs. The remaining 2 patients, both allergic to penicillin and treated with IV clindamycin, developed SSIs within the first postoperative week. Both cases required surgical drainage, hospitalization, and culture-based antibiotic therapy. Pathogens isolated included Streptococcus mitis, S. oralis, S. constellatus, and Haemophilus parainfluenzae, all resistant to clindamycin and erythromycin but sensitive to beta-lactams and fluoroquinolones. Both patients responded favorably to ciprofloxacin and metronidazole.</p><p><strong>Conclusions: </strong>This study highlights a significant risk of infection associated with clindamycin prophylaxis in penicillin-allergic patients undergoing orthognathic surgery. Cefazolin proved effective in preventing SSIs. These findings underscore the urgent need for updated, evidence-based prophylactic protocols in maxillofacial surgery, particularly for patients with beta-lactam allergies.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular complications related to Le Fort I osteotomy: a scoping review.","authors":"L-C Alves, J-M Alves, A-M Soares, D Gondim","doi":"10.4317/medoral.27277","DOIUrl":"https://doi.org/10.4317/medoral.27277","url":null,"abstract":"<p><strong>Background: </strong>Le Fort I (LFI) osteotomy represents a secure procedure employed for correcting facial deformities and may be coupled with other facial osteotomies. However, notwithstanding professional proficiency, this technique is not exempt from issues or morbidities. Therefore, the objective of this study was to relate the types of vascular complications associated with LFI.</p><p><strong>Material and methods: </strong>A scoping review was conducted with published articles up to April 2024 sourced from PubMed, LILACS, EMBASE, Scopus, Web of Science, Cochrane Library and Google Scholar. The analyzed data comprised: i) comprehensive details pertaining to each vascular lesion associated with LFI; and ii) pertinent anatomical characteristics along with their implications.</p><p><strong>Results: </strong>A total of 2,415 papers were identified. After removing duplicates and applying the inclusion and exclusion criteria, 33 studies were selected. All included patients had dentofacial deformities. The observed vascular lesions or alterations included: pseudoaneurysm, arteriovenous fistula, section or laceration, maxillary avascular necrosis, internal carotid artery dissection, middle cerebral artery ischemia, and cervicofacial hematoma. Notably, pseudoaneurysm emerged as the most prevalent complication. The surgical features associated with these complications included the incision of the maxillary bone, extending upwards from the pterygomaxillary junction to the pyriform aperture and involving the lateral walls of the nasal cavity. Additionally, disruption of the nasal septum was noted. The internal maxillary artery and its terminal branches are the most exposed to the surgical trauma.</p><p><strong>Conclusions: </strong>Understanding the potential complications, their clinical presentation, diagnostic methodologies, and management options is of paramount importance. Moreover, a multidisciplinary approach is frequently required to effectively address these complexities.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life after third molar surgery: a bibliometric analysis of randomized clinical trials.","authors":"E-F Maferano, J-L Júnior, T-R Ribeiro, P-R Martins-Filho, P-G Silva, A-F Granville-Garcia, F-W Costa","doi":"10.4317/medoral.27516","DOIUrl":"https://doi.org/10.4317/medoral.27516","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to conduct a bibliometric analysis of randomized controlled trials (RCTs) that evaluated quality of life following third molar surgery.</p><p><strong>Material and methods: </strong>A bibliometric analysis was performed in accordance with the BIBLIO checklist across 11 databases: Web of Science, MEDLINE, EMBASE, CINAHL, PsycINFO, The Cochrane Library, Livivo, LILACS, Scopus, Epistemonikos, and Google Scholar. RCTs that assessed quality of life after third molar surgery were included. Searches were conducted on September 20, 2024, and updated on May 5, 2025.</p><p><strong>Results: </strong>The initial search retrieved 4,217 records, of which 46 articles were included. The average annual number of publications between 2008 and 2024 was 2.7. A total of 192 authors contributed to the included studies, with the University of Mosul being the most productive institution. India and Iraq were the most prolific countries, each contributing five publications. Most articles were published in journals specializing in oral and maxillofacial surgery. The terms extracted from the titles co-occurrence analysis revealed distinct thematic clusters.</p><p><strong>Conclusions: </strong>Scientific output on quality of life following third molar surgery has shown consistent growth. Future RCTs are encouraged to incorporate qualitative approaches to gain a broader understanding of the clinical and social impacts of surgical interventions.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile and satisfaction of oral pathology/medicine postgraduates: a national multicenter study.","authors":"L-M Ferreira, M-P Maia-Lima, S Trezena, J-P Nascimento, F-E Oliveira, Á-A Duarte, D-R Martelli, F-D Alves, R-D Freitas, J-N Santos, M-C Aguiar, M-A Lopes, P-R Bonan, J-D Almeida, H Martelli-Júnior","doi":"10.4317/medoral.27436","DOIUrl":"https://doi.org/10.4317/medoral.27436","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the profile and professional satisfaction of postgraduate students in Oral Pathology (OP) and Oral Medicine (OM) enrolled in Stricto sensu programs across various Brazilian institutions.</p><p><strong>Material and methods: </strong>A cross-sectional, multicenter study surveyed 139 students from seven universities using a digital questionnaire with 29 questions on sociodemographic, motivations, and satisfaction. Data collection occurred between August and October 2024.</p><p><strong>Results: </strong>Most participants were female (63.3%), aged between 25 and 30 years (59.7%), and enrolled in doctoral programs (55.4%). The most important reasons for pursuing postgraduate studies were knowledge enhancement (86.3%), personal satisfaction (84.9%), and financial factors (51.1%). Despite high satisfaction with their programs, and most of them (64%) feeling prepared for the job market, many students felt that job opportunities in OP/OM were limited. Older students reported greater satisfaction with the program (p = 0.020). Ethnicity influenced satisfaction with the pedagogical project (p < 0.001). Students with partners were more satisfied with the accessibility of the faculty (p = 0.004), as were those with children (p < 0.001). Job prospects were associated with satisfaction in several aspects, including the program (p < 0.001), the pedagogical project (p < 0.001) and the physical infrastructure (p = 0.034).</p><p><strong>Conclusions: </strong>Demographic factors and personal perspectives were associated with students' satisfaction with their postgraduate programs. Addressing employment opportunities and improving program infrastructures, pedagogical projects, and access to advisors/professors could further enhance students' satisfaction and career outcomes in OP/OM.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in oral squamous cell carcinoma: a systematic review.","authors":"M López-Galindo, M-D Roques","doi":"10.4317/medoral.27565","DOIUrl":"https://doi.org/10.4317/medoral.27565","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is one of the most aggressive cancers in the oral cavity, often diagnosed at advanced stages, leading to significantly reduced survival rates. Traditional diagnostic methods, such as clinical examination and histopathology, have limitations in detecting early stages and assessing tumor variability. Molecular biomarkers, however, have shown great potential in overcoming these limitations by improving early diagnosis, prognosis, and personalized treatment. These biomarkers, when integrated with the TNM staging system, may provide more accurate and personalized clinical management.</p><p><strong>Material and methods: </strong>A systematic review was conducted by searching PubMed, Scopus, and Web of Science databases for studies on biomarkers in OSCC published between January 2018 and December 2024. The studies were selected based on strict inclusion and exclusion criteria, focusing on those that investigated biomarkers related to OSCC diagnosis, prognosis, and therapeutic implications.</p><p><strong>Results: </strong>This review includes 10 studies involving 1024 patients with OSCC. Key biomarkers such as Ki67, HSP60, Survivin, E-cadherin, and PD-L1 were significantly associated with tumor progression, lymph node metastasis, and poor prognosis. The combined use of these biomarkers with traditional histopathological methods could enhance diagnostic accuracy, allowing for better patient stratification and more targeted treatment approaches. Additionally, saliva-based biomarkers have emerged as a promising, non-invasive diagnostic tool with high sensitivity and specificity for early detection of OSCC.</p><p><strong>Conclusions: </strong>The identification of specific biomarkers can significantly enrich the diagnostic, prognostic, and therapeutic management of OSCC, complementing the TNM staging system. These biomarkers are linked to critical clinical variables such as metastasis, survival, and response to treatment. Saliva-based biomarkers hold promise due to their non-invasive nature, but further validation through multicenter studies and standardization is required for their widespread clinical adoption.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of implant-supported prosthesis design on peri-implant health: a cross-sectional study.","authors":"A Alahmari, R Figueiredo, M García-García, J Mir-Mari, E Valmaseda-Castellón, A Sánchez-Torres","doi":"10.4317/medoral.27464","DOIUrl":"https://doi.org/10.4317/medoral.27464","url":null,"abstract":"<p><strong>Background: </strong>Peri-implant diseases are common complications that may lead to dental implant failure. An adequate prosthesis design is crucial to reduce the risk of complications, and to improve peri-implant health. The present study was carried out to assess the effect of prosthesis design upon the presence of peri-implant inflammation.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted in patients with a single-unit implant-supported screw-retained crown. After removing the crowns, standardized photographs were made to assess several variables such as the length of the submucosal extension (SE) or the emergence angle (EA). Clinical signs of inflammation were also registered, and an experienced clinician probed the implants. The White (WES) and Pink Esthetic Scores (PES) were also recorded. Patients were classified into two groups according to the presence (positive bleeding on probing (BoP+)) or absence (negative bleeding on probing (BoP-)) of inflammation around the dental implant. Independent t-tests and one-way ANOVA were used to analyze the data.</p><p><strong>Results: </strong>A total of 90 implants were analyzed. Fifty-two implants (57.8%) had BoP+ while 38 (42.2%) had no signs of inflammation of the peri-implant tissues (BoP-). Long SE was significantly associated with BoP+ sites. The EA did not seem to be related to the presence of inflammation (p=0.642). PES/WES showed a negative correlation with buccal EA (r=-0.227; p=0.032).</p><p><strong>Conclusions: </strong>Long submucosal extensions in single-unit implant-supported crowns seem to be associated with peri-implant tissues inflammation (BoP+). A higher emergence angle on the buccal aspect was associated with poor esthetic outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Medicine: a retrospective analysis of patient profiles, diagnoses, and referral patterns in Mexico City.","authors":"A-M Figueroa-Ramos, G Anaya-Saavedra, M-E Irigoyen-Camacho, A Mosqueda-Taylor","doi":"10.4317/medoral.27481","DOIUrl":"https://doi.org/10.4317/medoral.27481","url":null,"abstract":"<p><strong>Background: </strong>Oral Medicine (OM) is a dental specialty dedicated to diagnosing and non-surgical managing of oral diseases, often in medically compromised patients. In Mexico, no prior studies have examined the scope of the clinical practice of this specialty; thus, this study aims to examine the characteristics of patients treated at three different reference centers of OM in Mexico City, focusing on their diagnoses, sources of referral, and treatments.</p><p><strong>Material and methods: </strong>This retrospective, observational and descriptive study reviewed 1,270 clinical records from three specialized OM centers between 2015 and 2022: a university clinic, an intrahospital service and a private OM practice. Demographic, clinical and therapeutic data were collected and analyzed using JMP Pro 16, with a significance level of p <0.05.</p><p><strong>Results: </strong>Most patients were women (71.6%), primarily in their sixth and seventh decades of life. Comorbidities were present in 74.7% of cases, and 63.2% of patients were on medications. In public institutions, the most frequent reason for consultation were tumors, while in the private clinic, it was burning mouth. Dentists were the main referrers (49%), yet only 24.2% of referrals included a diagnosis, of which 60% were accurate. The most prevalent oral conditions were non-odontogenic infections (26.4%), ulcerative and vesiculobullous lesions (15.2%), and oral potentially malignant disorders (14.8%). Pharmacologic treatment was provided to 71% of patients, while management of 29.9% included consultation with other specialists.</p><p><strong>Conclusions: </strong>This study highlights significant differences in patient profiles, diagnosis, and referral accuracy between the public and private services of OM. The low diagnostic precision in medical and dental referrals underscores the need to strengthen OM education. Additionally, the wide spectrum of oral and maxillofacial disorders and their treatments emphasize the importance of multidisciplinary management and integration with other medical specialties. These findings support the need to evaluate educational programs, optimize referral pathways, and improve the quality of OM care in Mexico.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEDCYDO - SEGER - SEMO CONGRESS MADRID 2025, 8-10 MAY. Proceedings and Abstract.","authors":"","doi":"10.4317/medoral.1122335667805","DOIUrl":"10.4317/medoral.1122335667805","url":null,"abstract":"","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":"30 Suppl1","pages":"1-126"},"PeriodicalIF":2.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}