Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Novel approach in the resection of oral maxillary tumours.","authors":"P Cea-Arestín, A Bilbao-Alonso, A García-García, C Menéndez-Lago","doi":"10.4317/medoral.27046","DOIUrl":"https://doi.org/10.4317/medoral.27046","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity tumours represent a global oral health issue due to their prevalence and incidence, in this paper, we will explain the procedure for the removal of various tumours and the restoration of the patient's anatomy, function and aesthetics through a novel approach that rely on a temporal muscle flap for the reconstruction of soft tissues in the surgical area.</p><p><strong>Material and methods: </strong>This study is based on an analysis of temporal flap technique data, collected at the public health hospital of Santiago de Compostela (CHUS), from 2015 to 2024.</p><p><strong>Results: </strong>The results are shown in table 1, being the most relevant data the fact of having a serie of 11 successful cases treated with temporal flap. The surgical technique involves tumor resection, preferably through an intraoral approach.</p><p><strong>Conclusions: </strong>This novel technique must be taken into account when solving this type of oncological cases with associated maxillectomy due to it's better results in terms of reconstruction of tissues and anatomy, shorter execution time and possibility of offering immediate function to the patient, leading to less number of surgeries with their consequent lower morbidity and social-health and economic savings.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional states in patients with cancer or with suspected oral potentially malignant disorders: a cross-sectional study in an oral medicine setting.","authors":"M Bazzano, R Mauceri, G Marcon, M Coppini, D Montemaggiore, G Campisi","doi":"10.4317/medoral.26989","DOIUrl":"https://doi.org/10.4317/medoral.26989","url":null,"abstract":"<p><strong>Background: </strong>This cross-sectional study aims to investigate the emotional states (i.e., anxiety, depression, and stress) of 4 distinct groups of patients attending an Oral Medicine setting.</p><p><strong>Material and methods: </strong>four distinct subgroups of patients have been enrolled: 25 patients with OSCC (OSCC group); 25 patients with other solid tumor (ONCO group), 25 cancer patients with MRONJ (MRONJ group), 25 patients with oral potentially malignant disorder (OPMD group). Standardized assessment tools (i.e. Beck Depression Inventory (BDI) and Depression Anxiety Stress Scales-21 (DASS-21) questionnaires) were utilized to evaluate the patients' emotional states.</p><p><strong>Results: </strong>Among the 100 patients enrolled, 59% of whom were female, and most patients were aged between 70 and 80 years. The mean total BDI score was 16.57, and the mean total DASS-21 score was 15.32. The mean scores of the OSCC group showed moderate depression, all the other groups were classified as mild depression. The OPMD group showed a significantly higher level of anxiety.</p><p><strong>Conclusions: </strong>Patients in the oral medicine setting may face various diseases and may develop emotional states that affect their treatment adherence. For effective management of these emotional states, the presence of a multidisciplinary team, including a psychologist, and the adoption of individualized approaches, seem to be necessary.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral leukoplakia: still an enigmatic disorder.","authors":"J-M Aguirre-Urizar","doi":"10.4317/medoral.27214","DOIUrl":"https://doi.org/10.4317/medoral.27214","url":null,"abstract":"<p><strong>Background: </strong>Oral leukoplakia is the most frequent and representative potentially malignant disorder of what is known as oral precancer. Since the first descriptions, this pathology, which initially seems simple, has been the subject of controversy and discussion, and it still maintains multiple unknowns and enigmas to be solved.</p><p><strong>Material and methods: </strong>A narrative and integrative review of the epidemiological, pathogenetic, diagnostic, prognostic and therapeutic aspects of this important oral disorder has been carried out.</p><p><strong>Results: </strong>Oral leukoplakia still presents multiple enigmas regarding its actual epidemiology, its multifactorial and multistage pathogenesis, its definition and diagnosis, its malignant development and its treatment.</p><p><strong>Conclusions: </strong>We must conduct well-designed prospective studies on this fascinating oral pathology, on well-diagnosed clinical cases with clinicopathological criteria agreed and accepted by the scientific community. Only in this way will we be able to clarify the enigmas it still presents.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical behavior of two-piece zirconia implants. A systematic review.","authors":"S Bazal-Bonelli, M Castro-Janeiro, J Ríos-Barbero, M Cano Sánchez de Tembleque, J López-Quiles, C Meniz-García, J Cortés-Bretón Brinkmann","doi":"10.4317/medoral.26752","DOIUrl":"https://doi.org/10.4317/medoral.26752","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aimed to evaluate the clinical behavior of two-piece zirconia implants (T-PZI) in terms of overall implant survival and success rates, marginal bone loss (MBL) complication rates, and others biological parameters.</p><p><strong>Material and methods: </strong>PRISMA guidelines were followed, and the review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). An automated search was conducted in four databases (Medline/PubMed, Scopus, Web of Science, and Cochrane Library), as well as a manual search for relevant clinical articles published until 18 May 2024. The review included human studies with at least five patients in which T-PZI were placed. Quality of evidence was evaluated using the Newcastle-Ottawa Quality Assessment Scale and the Cochrane risk-of-bias tool for randomized trials version 2 (RoB 2).</p><p><strong>Results: </strong>Six studies met the inclusion criteria and were included for analysis, with a total of 298 T-PZI. A survival rate of 96.31% was recorded with follow-up periods ranging from 18.4±10.4 months to 111.1±2.2 months. The success rate ranged from 63 to 100% and MBL ranged from 0.130.6 to 1.38±0.81mm Conclusions: T-PZI may offer a reliable alternative to titanium dental implants, achieving a survival rate of 96.31%, acceptable rates of MBL and adequate biological parameters. However, the findings of the review must be treated with caution, as the data obtained are derived from the early stages of this new development in ceramic dental implants. More comparative studies are needed in order to determine the viability of T-PZI in different clinical situations.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of platelet-rich-fibrin for the treatment of alveolar osteitis: a systematic review and meta-analysis.","authors":"C Ávila-Oliver, V Veloso, G Laissle, A-M Rojas, F Verdugo-Paiva, J Ramos-Rojas","doi":"10.4317/medoral.26801","DOIUrl":"https://doi.org/10.4317/medoral.26801","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aims to provide an updated summary of the available evidence on the role of platelet-rich fibrin (PRF) in the treatment of alveolar osteitis.</p><p><strong>Material and methods: </strong>Searches were conducted in several electronic databases, including PubMed, EBSCO, Cochrane Central Register of Controlled Trials (CENTRAL) LILACS and ClinicalTrials.gov. No date or language restrictions were applied. Two reviewers independently evaluated eligible studies according to predefined criteria and extracted data using a standardized form. Meta-analyses were performed to estimate results and the certainty of evidence, using the GRADE approach, was assessed.</p><p><strong>Results: </strong>The search strategy yielded 1.706 references. Finally, 4 randomized trials were included and assessed quantitatively. Overall, the risk of bias was low for 75% of the domains reviewed across studies. The studies included a total of 179 patients, where the intervention group received PRF, and the control group received several treatment alternatives, including iodoform gauze, zinc oxide eugenol, and saline solution. Results showed that the use of PRF may decrease pain severity measured on day 3 (MD -1.66, CI 95%, -4.11 to 0.78) and on day 7 (MD -1.57, CI 95%, -4.00 to 0.88), and improves alveolar socket healing (SMD 2.25; 95% CI 1.70 to 2.80; p<0.00001; I2=12%).</p><p><strong>Conclusions: </strong>The results of this study demonstrate that PRF improves alveolar healing, reduces analgesic use in patients, and likely increases overall clinical efficacy, making it a valuable alternative in the treatment of alveolar osteitis. Despite these findings, this review also showed a great degree of uncertainty on the impact of PRF on pain severity associated with alveolar osteitis. Although these results are promising, further randomized clinical trials with standardized methodologies must be performed to validate these findings.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myofibromas of the jawbones in pediatric patients. A clinicopathological study.","authors":"G-C Barajas-Torres, N-L Villanueva-Moreno, H Rincón-Rodríguez, V Cuairán-Ruidiaz, H Márquez-González, J-R Murillo-Eliosa, A Mosqueda-Taylor","doi":"10.4317/medoral.27021","DOIUrl":"https://doi.org/10.4317/medoral.27021","url":null,"abstract":"<p><strong>Background: </strong>Myofibromas are infrequent neoplasms that rarely occur in the jawbones. The aim of this study is to present a series of cases of these tumors affecting the jawbones in pediatric patients, as well as to describe their diagnostic methodology and therapeutic approach.</p><p><strong>Material and methods: </strong>retrospective study of a series of myofibromas of the jawbones diagnosed and treated in a single medical institution in Mexico City from 2002-2022.</p><p><strong>Results: </strong>There were 14 cases with a median age of 6.5 years (IQR:1-12). Mandible was affected in 8 cases (57.1%), maxilla in 5 (35.8%) and only one case (7.1%) occurred in both jaws. Microscopically, the lesions were composed predominantly by spindle cells, as well as stellate and sometimes pleomorphic in shape, most of which were positive for smooth muscle actin. All cases were treated with complete excision of the lesion and only one presented recurrence.</p><p><strong>Conclusions: </strong>Once the diagnosis is confirmed and other spindle cell neoplasms have been excluded, resection with free margins represents the treatment of choice.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of piezoelectric surgery and conventional techniques in the enucleation of cysts and tumors in the jaws: a systematic review and meta-analysis.","authors":"L Suárez-Pérez, M Peralta-Mamani, R-T Velázquez-Cayón","doi":"10.4317/medoral.26799","DOIUrl":"https://doi.org/10.4317/medoral.26799","url":null,"abstract":"<p><strong>Background: </strong>Despite the comprehensive classifications provided by the WHO, the most common lesions include radicular cysts, dentigerous cysts, odontogenic keratocysts, ameloblastomas, and odontomas. The piezoelectric technique has shown effectiveness in removing intraosseous pathologies by relying on ultrasonic microvibrations, which help preserve soft and vascular tissues. Precision in manipulating intraosseous pathology can impact the prognosis and improve the surgical procedure by controlling hemorrhage and promoting microscopic benefits. While previous research has compared the advantages of piezoelectric surgery and rotational methods, a systematic review is needed to consolidate the available information on this specific clinical issue.</p><p><strong>Material and methods: </strong>A search strategy was developed with de PRISMA statement. PubMed, Web of Science, Scopus, and Embase electronic databases were searched. The bibliographic search was conducted in December 2023. The methodological quality of the studies followed the Joanna Briggs Institute (JBI) critical evaluation tool for randomized clinical trials.</p><p><strong>Results: </strong>The final sample comprised 5 clinical trials, involving 231 cysts and 120 tumors in the experimental group. The mean age of participants was 30.6 years, with 196 men and 141 women included in the study. However, conventional surgery is faster than piezosurgery, both techniques exhibited similarities in epithelial perforation, soft tissue damage, edema, postoperative infections, and occurrences of paresthesia. Regarding recurrence, no statistically significant difference was observed between the two techniques (p-value=0.339; 95% confidence interval, -0.093-0.270).</p><p><strong>Conclusions: </strong>The surgical removal of benign odontogenic cysts and tumors in the jaws using piezosurgery yielded slight intraoperative and postoperative advantages compared to conventional rotary surgery, except for the duration of surgical procedures. It shows reduced intraoperative hemorrhage and postoperative pain but similar outcomes in other variables. The results should be interpreted with caution, more studies are needed to obtain a more robust result.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the prevalence of Behcet's disease in recurrent aphthous ulceration worldwide: a systematic review.","authors":"A-B Azevêdo, A-P Sobral, C-A Faria, J-S Sousa, W-R Silva, M-M Silveira","doi":"10.4317/medoral.27023","DOIUrl":"https://doi.org/10.4317/medoral.27023","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS).</p><p><strong>Material and methods: </strong>A search was performed in Scopus, Medline/PubMed, The Cochrane Library and Web of Science databases, according to PRISMA. In addition, a search was carried out in the DANS Easy Archive to access gray literature and a manual search in the reference list of included studies was used as an additional resource to refine the search. Cross-sectional studies in patients with recurrent aphthous stomatitis evaluating the diagnosis of Behcet's syndrome were analyzed to identify prevalence. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to assess the methodological quality of the articles.</p><p><strong>Results: </strong>The study design, sample size, sex, International Study Group (ISG) diagnostic criteria and prevalence of the syndrome were evaluated. After screening and reading the articles in full, 7 met the inclusion criteria. The articles involved a total of 2841 participants with recurrent aphthous ulcerations, with 141 having a diagnosis of Behcet's syndrome. Studies were of good quality as assessed by the JBI Critical Appraisal Checklist for cross-sectional studies.</p><p><strong>Conclusions: </strong>The prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS) is generally low, with similar frequency in both sexes and more common in the range of countries that extends from the Mediterranean Basin to the Far East.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity, extent, distribution and predisposing factors of gingival recession in Turkish patients: a cross-sectional study.","authors":"H Çelik, H-S Güngörmek","doi":"10.4317/medoral.26956","DOIUrl":"https://doi.org/10.4317/medoral.26956","url":null,"abstract":"<p><strong>Background: </strong>The aim of this cross-sectional study was to assess the extent, severity, distribution and potential predisposing factors of gingival recession (GR), utilizing a questionnaire and clinical periodontal measurements obtained from Turkish patients.</p><p><strong>Material and methods: </strong>A total of 534 subjects were examined. Participants meeting the inclusion criteria evaluated by dental hygiene habits, educational level, smoking habit and past orthodontic treatment. Plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP), clinical attachment level (CAL), gingival thickness (GT), high frenum attachment, and mobility were recorded on the tooth with GR. Probe transparency (PT), crown width/crown length ratio (CW/CL), papilla height (PH) and height of gingival scallop were measured on the index tooth (#11FDI). The GR severity was categorized by using Miller's classification.</p><p><strong>Results: </strong>Of the 534 individuals examined in this study, 376 (70.4%) had gingival recession, while 262 patients (49%) were meeting the inclusion criteria and 2,721 teeth (37%) were affected. The majority of the teeth (44.8%) showed Miller class I. The highest GR frequency was detected in incisors (39.5%), particularly in mandible. The correlation between GR and PI (p=0.025), PD (p=0.034), PH (p=0.007), CW/CL (p=0.009), CAL (p<0,001), PT (p<0,001) was found statistically significant. No statistical relation was found between tooth brushing duration (p>0,05), tooth brushing frequency (p>0,05) and gingival recession.</p><p><strong>Conclusions: </strong>Gingival recession is a multifactorial condition significantly influenced by clinical and anatomical parameters such as PI, PH, CW/CL, PT while toothbrushing habits, including duration and frequency, appear to have a minimal impact.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periapical radiographs vs cone beam CT imaging for the evaluation of peri-implant bone defects: an ex vivo study.","authors":"N-G Tzortzakis, S Damaskos, K Dimakopoulou, E Chatzipetros, C Angelopoulos","doi":"10.4317/medoral.26777","DOIUrl":"https://doi.org/10.4317/medoral.26777","url":null,"abstract":"<p><strong>Background: </strong>Data on the radiographic interpretation of peri-implantitis is still controversial. Thus, our study aimed to: a) investigate the detectability rate of ex-vivo induced peri-implant bone defects (PBDs) between observers using two different imaging methods; Cone Beam Computed Tomography (CBCT) and Periapical Radiographs (PAs), b) investigate the observers' agreement on their ability to detect PBDs according to their level of expertise and, c) determine the sensitivity and specificity of the imaging methods used to detect induced PBDs.</p><p><strong>Material and methods: </strong>Two dried human mandibles were used in which ten dental implants were placed and eight PBDs were created simulating clinical conditions. Radiographic examination using PAs and two CBCT modes [CBCT/N (normal/0.3mm3), and CBCT/HR (HiRes/0.15mm3)] was performed at all experimental stages. All PBDs were recorded for their dimensions using a dental periodontal probe as they were used as a gold standard (GS). Finally, 145 images (49 PAs, 48 CBCT/N, and 48 CBCT/HR) were created and evaluated by nine independent observers. Three oral radiologists (OR), three implantologists (IS), and three general practitioners (GP).</p><p><strong>Results: </strong>PBDs were detected at a higher rate by ORs compared to ISs, and GPs. However, the rate of their agreement, did not reach the nominal level of significance (z-test p-value> 0.05), and also between observers of the same expertise, and between the different imaging methods used: CBCT and PAs (z-test p-value> 0.05). In total, the sensitivity of the CBCTs and PAs method was 95% and 80.5%, respectively. While the specificity for all methods was lower, 57%, 62.2% and 50.4% for CBCT/N, CBCT/H and PAs methods, respectively.</p><p><strong>Conclusions: </strong>Although CBCT performs better than PAs in ex-vivo induced PBDs, further research is needed to evaluate if the present results can be extrapolated to other clinical scenarios and defect configurations.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}