Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Periapical radiographs vs cone beam CT imaging for the evaluation of peri-implant bone defects: an ex vivo study.","authors":"N-G Tzortzakis, S Damaskos, K Dimakopoulou, E Chatzipetros, C Angelopoulos","doi":"10.4317/medoral.26777","DOIUrl":"https://doi.org/10.4317/medoral.26777","url":null,"abstract":"<p><strong>Background: </strong>Data on the radiographic interpretation of peri-implantitis is still controversial. Thus, our study aimed to: a) investigate the detectability rate of ex-vivo induced peri-implant bone defects (PBDs) between observers using two different imaging methods; Cone Beam Computed Tomography (CBCT) and Periapical Radiographs (PAs), b) investigate the observers' agreement on their ability to detect PBDs according to their level of expertise and, c) determine the sensitivity and specificity of the imaging methods used to detect induced PBDs.</p><p><strong>Material and methods: </strong>Two dried human mandibles were used in which ten dental implants were placed and eight PBDs were created simulating clinical conditions. Radiographic examination using PAs and two CBCT modes [CBCT/N (normal/0.3mm3), and CBCT/HR (HiRes/0.15mm3)] was performed at all experimental stages. All PBDs were recorded for their dimensions using a dental periodontal probe as they were used as a gold standard (GS). Finally, 145 images (49 PAs, 48 CBCT/N, and 48 CBCT/HR) were created and evaluated by nine independent observers. Three oral radiologists (OR), three implantologists (IS), and three general practitioners (GP).</p><p><strong>Results: </strong>PBDs were detected at a higher rate by ORs compared to ISs, and GPs. However, the rate of their agreement, did not reach the nominal level of significance (z-test p-value> 0.05), and also between observers of the same expertise, and between the different imaging methods used: CBCT and PAs (z-test p-value> 0.05). In total, the sensitivity of the CBCTs and PAs method was 95% and 80.5%, respectively. While the specificity for all methods was lower, 57%, 62.2% and 50.4% for CBCT/N, CBCT/H and PAs methods, respectively.</p><p><strong>Conclusions: </strong>Although CBCT performs better than PAs in ex-vivo induced PBDs, further research is needed to evaluate if the present results can be extrapolated to other clinical scenarios and defect configurations.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing nerve injuries in oral surgery: a survey-based study on prevention and management.","authors":"N Agbulut","doi":"10.4317/medoral.26995","DOIUrl":"https://doi.org/10.4317/medoral.26995","url":null,"abstract":"<p><strong>Background: </strong>Understanding and mitigating iatrogenic nerve injuries, specifically IAN and LN, is crucial in the field of oral and maxillofacial surgery. These injuries may lead to profound sensory deficits, pain syndromes, and impaired quality of life for patients. This study aims to assess the prevention and management practices for inferior alveolar nerve and lingual nerve injuries among dental professionals. By gathering data through a survey, the study seeks to evaluate current experiences, awareness, and protocols, ultimately contributing to improved guidelines for nerve injury management.</p><p><strong>Material and methods: </strong>This cross-sectional study utilized an online survey distributed via Turkish Dental Association to registered dentists and specialists. The predictor variables were the procedure types associated with nerve injuries. The main outcome variables were preventive measures and patient management strategies. Demographic profiling including age, years in profession, specialty, and type of current workplace were determined as covariates.</p><p><strong>Results: </strong>1477 respondents provided complete answers, with questions addressing demographics, nerve injury incidents, preventive measures, and management strategies. The most reported IAN and LN injuries were linked to dental implant surgery (n=1067), mandibular third molar surgery (n=958), and local anesthesia applications (n=459). Interestingly, more than 30% of participants reported no experience with nerve injuries. For preventive measures in tooth extraction, 281 respondents performed coronectomies, and in implant surgery over 80% of the participants evaluated tomographic images in high-risk cases. Most common management strategies for paresthesia included vitamin B12 (n=1093) and NSAIDs (n=1051). The use of gabapentin, and non-medical treatments like biofeedback and alternative therapies were rarely employed.</p><p><strong>Conclusions: </strong>The survey revealed a diverse range of practices regarding nerve injury prevention and management, emphasizing the need for evidence-based approaches and consensus guidelines. Understanding current practices for managing IAN and LN injuries can inform future guidelines, reduce complications, and improve patient outcomes in oral and maxillofacial surgery.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates.","authors":"G-V Fernandes, B-G Martins, A Heboyan, R-M Castilho, J-C Fernandes","doi":"10.4317/medoral.27033","DOIUrl":"https://doi.org/10.4317/medoral.27033","url":null,"abstract":"<p><strong>Background: </strong>The primary goal of this in vivo study was to ascertain if systemic bisphosphonates (BPs) positively affect bone repair in non-critical defects when assisted with a carbonated hydroxyapatite graft biomaterial (Biomat).</p><p><strong>Material and methods: </strong>Thirty-six female rats were allocated into two control groups (blood clot [BC] and alloplastic biomaterial); two groups with zoledronate (third-generation BPs): Zol.BP and Zol.BP+Biomat; and two groups with clodronate (first-generation BPs): Clod.BP and the Clod.BP+Biomat. The experimental groups started the application of BP 60 days before surgery. Then, a 2 mm non-critical defect was performed in the rats' femur and filled according to the group. All animals were euthanized 30 days after surgery, and the samples were collected for histological and histomorphometry analysis, respectively, for descriptive and quantitative analyses.</p><p><strong>Results: </strong>Zol.BP+Biomat had greater new bone formation, whereas clodronate presented high osteogenic potential, significantly increasing the observed levels of newly formed bone even in the absence of the biomaterial. Histomorphometrically, BC had 2% bone formation compared to the biomaterial group (5%). Zol.BP and Col.BP achieved bone formation of 6-fold (12%, p>0.05) and 9.5-fold (19%, p<0.05), respectively, when compared with BC. Zol.BP+Biomat group presented the highest value found for newly formed bone (24%), 12-fold more than BC (p<0.001) and 4.8-fold more than the biomaterial group (p<0.01).</p><p><strong>Conclusions: </strong>It is possible to conclude that the systemic use of BP positively affected non-critical bone defects when associated with biomaterials, mainly when the third generation of BPs was used in this association.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of shape and thickness variations in patient-specific implants for t-shaped genioplasty.","authors":"E-F Akkoyun, T Pergel","doi":"10.4317/medoral.27065","DOIUrl":"https://doi.org/10.4317/medoral.27065","url":null,"abstract":"<p><strong>Background: </strong>T-shaped genioplasty is a versatile surgical technique used to correct chin deformities by altering its vertical, transverse, and sagittal dimensions. Despite numerous advancements in patient-specific implants (PSIs), the biomechanical impact of PSI thickness and the number of screws used for fixation remain unexplored. This study aims to evaluate the effects of PSI thickness and screw configurations on fixation stability in T-shaped genioplasty using finite element analysis.</p><p><strong>Material and methods: </strong>Mandibular computed tomography data were used to construct 12 three-dimensional models with varying PSI thicknesses (0.6 mm, 0.9 mm, and 1.2 mm) and screw configurations (five, six, seven, and eight screws). T-shaped osteotomies were applied to create narrowing and widening genioplasty models, with iliac bone grafts placed in widening scenarios. Horizontal forces of 50 N were applied bilaterally, and fixation stability was evaluated using von Mises stress and bone displacement. Fixation was considered stable when bone displacement amounts were below 1 mm.</p><p><strong>Results: </strong>In narrowing models, fixation stability was achieved with five screws and a 1.2 mm PSI or seven screws with a 0.9 mm or 1.2 mm PSI, showing stress values within titanium's yield strength limits. For widening models, stable fixation was achieved with six screws and a 0.9 mm or 1.2 mm PSI, or eight screws across all tested thicknesses. Bone displacement was minimal with thicker PSIs and higher screw counts, demonstrating improved stability.</p><p><strong>Conclusions: </strong>This study highlights the importance of PSI customization in optimizing fixation stability in T-shaped genioplasty. A minimum of five screws with a 1.2 mm plate or seven screws with a 0.9 mm plate is suggested for narrowing, while six screws with a 0.9 mm plate or eight screws with any tested thickness are sufficient for widening. Future research should address combined movements, dynamic loading, and long-term outcomes to refine PSI fixation strategies further.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between rheumatoid arthritis and periodontitis: a study based on a two-sample mendelian randomisation analysis.","authors":"Q Cai, C Li, Z Quan, X Yang, T Chen, X Han, X Xu","doi":"10.4317/medoral.26848","DOIUrl":"https://doi.org/10.4317/medoral.26848","url":null,"abstract":"<p><strong>Background: </strong>The association between Rheumatoid arthritis (RA) and Periodontitis (PD) has been increasingly recognised, yet traditional epidemiological studies face challenges in establishing associations. Therefore, this study aims to genetically assess the association between RA and PD through Mendelian randomisation (MR) analysis, using genetic variations as instrumental variables.</p><p><strong>Material and methods: </strong>Data on RA and PD were downloaded from the EBI website. The RA data contained 8,255 cases and 409,001 controls, with a total of 24,175,266 SNPs; the chronic PD data contained 950 cases and 409,001 controls, with a total of 11,842,647 SNPs; the acute PD data contained 128 cases and 456,220 controls, with a total of 11,842,647 SNPs. Additionally, the potential association between RA and PD was investigated. The intercept between Mendelian randomisation (MR)-Egger regression, MR-PRESSO test results and funnel plots was used to analyse the horizontal pleiotropy of SNPs along with the effect of individual SNPs on inverse-variance weighting (IVW) analysis results, assessed using the leave-one-out method.</p><p><strong>Results: </strong>In total, 26 SNPs highly associated with RA were screened; MR-Egger regression (OR=1.242, 95% CI (1.032-1.494), P=0.031), WM (OR=1.190, 95% CI (1.015-1.395), P=0.032), IVW (OR=1.191, 95% CI (1.053-1.348), P=0.006) and weighted mode (OR=1.212, 95% CI (1.043-1.409), P=0.019) suggested that RA was a likelihood factor for chronic PD, whereas RA was not associated with the incidence of acute PD, and the Cochran's Q test indicated no statistical heterogeneity between SNPs highly associated with RA. Moreover, analyses using the intercept between the MR-Egger regression, MR-PRESSO test results and funnel plot revealed no horizontal pleiotropy in SNPs highly associated with RA.</p><p><strong>Conclusions: </strong>Rheumatoid arthritis was genetically identified as a likelihood factor for PD and the onset of chronic PD, but no association was observed between RA and acute PD.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends in pharmacological treatment of inferior alveolar nerve sensory disorders: a scoping review.","authors":"B-D Mesquita, A-C Gomes, B-C Vasconcelos, C-A Lago, M-R Arruda, E-S Andrade","doi":"10.4317/medoral.26519","DOIUrl":"10.4317/medoral.26519","url":null,"abstract":"<p><strong>Background: </strong>Sensory disorders of the inferior alveolar nerve, often arising from dental procedures, markedly impact the quality of life of patients. This article proposes a scoping review to analyze emerging trends in pharmacological treatment for these disorders, addressing scientific gaps and clinical practices.</p><p><strong>Material and methods: </strong>The review followed the PRISMA-ScR protocol, conducting data searches across various databases, including PubMed and Cochrane, until March 2024. Case studies and series related to patients with sensory disorders of the inferior alveolar nerve undergoing pharmacological treatment were included.Parte inferior do formulário Results: Out of the initial 542 records, 7 studies were included after rigorous selection, displaying low bias risk. Medicinal therapies varied, encompassing analgesics, corticosteroids, anesthetics, and vitamin complexes. Dipyrone stood out in the preoperative phase, while prednisone proved effective in paresthesias. Selegiline, an MAO-B inhibitor, introduced an innovative approach.</p><p><strong>Conclusions: </strong>Agents such as selegiline offer an innovative approach to sensory restoration, while corticosteroids exhibit variable efficacy. Dipyrone is effective in preoperative pain control, and vitamin complexes provide regenerative and neuroprotective benefits. However, it is essential to consider that treatment success may vary and to address the individual needs of patients.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e170-e178"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of Dexmedetomidine as an additive to local anesthetics in dental procedures: A systematic review.","authors":"D-A Diniz, A-J França, J-R Laureano-Filho, E-P Pellizzer, S-L Moraes, B-C Vasconcelos","doi":"10.4317/medoral.26439","DOIUrl":"10.4317/medoral.26439","url":null,"abstract":"<p><strong>Background: </strong>This review aimed to assess if the use of dexmedetomidine as an additive to local anesthetics promotes greater safety and efficacy than local anesthetics alone in dental procedures.</p><p><strong>Material and methods: </strong>the systematic review was structured according to the PICO strategy and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. Studies were included based on the eligibility criteria, and data from the included studies were collected by one author. An additional author reviewed the compilation. Altogether, nine studies were included: eight randomized clinical trials and one controlled clinical trial. Of these, six were related to tooth extraction. Most studies reported the use of lidocaine as the local anesthetic. Levobupivacaine was used in one study.</p><p><strong>Results: </strong>In total, 352 patients were evaluated. Despite the heterogeneity between studies, it can be suggested that when used as an additive to local anesthetics, dexmedetomidine has the potential to decrease postoperative pain and latency period and prolong anesthetic duration.</p><p><strong>Conclusion: </strong>There are scant reviews that summarizes the effectiveness of dexmedetomidine as an adjuvant to local anesthetics. These studies can positively impact the lives of the concerned population.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e160-e169"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular endothelial growth factor immunoexpression in oral paracoccidioidomycosis.","authors":"E-S Dias, L-C Freitas, M Miyazawa, D-A Nogueira, C-E Oliveira, A-A Pereira, J-A Hanemann","doi":"10.4317/medoral.26886","DOIUrl":"10.4317/medoral.26886","url":null,"abstract":"<p><strong>Background: </strong>Paracoccidioidomycosis (PCM) is a systemic mycosis endemic and limited to Latin America. Brazil is responsible for more than 80% of diagnosed cases in the world. Since PCM is not a notifiable disease, there are still no accurate data on its incidence in Brazil. Vascular endothelial growth factor (VEGF) is considered the main vascular endothelial growth factor expressed in the process of angiogenesis, both under physiological and pathological conditions. To date, there are not studies in the literature that evaluated the expression of VEGF in oral PCM lesions. Therefore, the objective of this study was to evaluate the prevalence of oral lesions of PCM diagnosed from 1998 to 2020; to analyze the immunoexpression of VEGF in oral lesions of PCM; and to compare the VEGF immunostaining with the clinical and microscopic aspects of these lesions.</p><p><strong>Material and methods: </strong>Clinical data of 98 cases of patients with oral PCM were evaluated. A total of 41 selected cases were quantitatively and qualitatively analysed by immunohistochemistry for VEGF.</p><p><strong>Results: </strong>Our results showed that oral PCM preferentially affects white males, with mean age of 50.2 years, and the gingiva and the alveolar ridge. It was not possible to correlate VEGF immunoexpression with clinical and microscopic variables.</p><p><strong>Conclusions: </strong>Oral PCM is a relatively uncommon pathological condition and that, in our sample, the immunoexpression of VEGF was mild and observed in a reduced number of cases.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e240-e246"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating quality of life in third molar surgery: a scoping review of the postoperative symptom severity (PoSSe) scale.","authors":"E-F Maferano, E-L Filho, P-G Silva, A-F Granville-Garcia, R-T Firmino, M-D Perazzo, P-R Martins-Filho, F-W Costa","doi":"10.4317/medoral.26839","DOIUrl":"10.4317/medoral.26839","url":null,"abstract":"<p><strong>Background: </strong>This scoping review evaluated the key dimensions of quality of life impacted by third molar surgery as assessed by the Postoperative Symptom Severity (PoSSe) scale, and their variations across diverse populations and clinical contexts.</p><p><strong>Material and methods: </strong>A comprehensive literature search was performed across multiple databases including MEDLINE, EMBASE, CINAHL, PsycINFO, The Cochrane Library, Livivo, LILACS, Web of Science, Scopus, Epistemonikos, and Google Scholar on April 30, 2024, with an update on July 31, 2024. We included analytical observational studies and randomized clinical trials that utilized the PoSSe scale to assess quality of life. There were no restrictions based on language, location, or publication period. Data from eligible studies were extracted and analyzed descriptively.</p><p><strong>Results: </strong>The search identified 3,438 records, with 31 studies ultimately included. These studies employed the PoSSe scale in various methodological designs to primarily assess quality of life following lower third molar removal. The dimensions most affected were feeding, appearance, and pain, which showed significant correlations with edema, trismus, and analgesic use. Additional influencing factors included gender, tobacco use, surgeon skill level, Pell and Gregory classification, and preemptive analgesia.</p><p><strong>Conclusions: </strong>This review has demonstrated the PoSSe scale's effectiveness in evaluating the multifaceted impacts of third molar surgery on patient quality of life, sensitive to differences in surgical techniques, surgeon experience, and patient-specific factors. Future research should explore longitudinal assessments with the PoSSe scale to optimize surgical practices and improve long-term patient outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e232-e239"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of ChatGPT 3.5, 4.0, 4o and Gemini in diagnosing oral potentially malignant lesions based on clinical case reports and image recognition.","authors":"P Pradhan","doi":"10.4317/medoral.26824","DOIUrl":"10.4317/medoral.26824","url":null,"abstract":"<p><strong>Background: </strong>The accurate and timely diagnosis of oral potentially malignant lesions (OPMLs) is crucial for effective management and prevention of oral cancer. Recent advancements in artificial intelligence technologies indicates its potential to assist in clinical decision-making. Hence, this study was carried out with the aim to evaluate and compare the diagnostic accuracy of ChatGPT 3.5, 4.0, 4o and Gemini in identifying OPMLs.</p><p><strong>Material and methods: </strong>The analysis was carried out using 42 case reports from PubMed, Scopus and Google Scholar and images from two datasets, corresponding to different OPMLs. The reports were inputted separately for text description-based diagnosis in GPT 3.5, 4.0, 4o and Gemini, and for image recognition-based diagnosis in GPT 4o and Gemini. Two subject-matter experts independently reviewed the reports and offered their evaluations.</p><p><strong>Results: </strong>For text-based diagnosis, among LLMs, GPT 4o got the maximum number of correct responses (27/42), followed by GPT 4.0 (20/42), GPT 3.5 (18/42) and Gemini (15/42). In identifying OPMLs based on image, GPT 4o demonstrated better performance than Gemini. There was fair to moderate agreement found between Large Language Models (LLMs) and subject experts. None of the LLMs matched the accuracy of the subject experts in identifying the correct number of lesions.</p><p><strong>Conclusions: </strong>The results point towards cautious optimism with respect to commonly used LLMs in diagnosing OPMLs. While their potential in diagnostic applications is undeniable, their integration should be approached judiciously.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e224-e231"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}