Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Evaluation of the incidence of obstructive sleep apnea in mandibular fracture patients before and after treatment with the STOP-BANG questionnaire.","authors":"M Jafari, S Samieirad, R-K Goharian, R Grillo","doi":"10.4317/medoral.27047","DOIUrl":"10.4317/medoral.27047","url":null,"abstract":"<p><strong>Background: </strong>Mandibular fractures are common injuries, leading to various complications, including obstructive sleep apnea (OSA). The aim of this study was to evaluate the occurrence of OSA in relation to mandibular fracture type before and after treatment using the STOP-BANG questionnaire.</p><p><strong>Material and methods: </strong>This prospective study was conducted on patients admitted to Shahid Kamyab Hospital from 2022 to 2023 with mandibular fractures. Patients were classified based on the type and location of fracture, age, gender, and cause. The primary predictor variable was the type of mandibular fracture. The primary outcome variable was the occurrence of OSA as measured by the STOP-BANG questionnaire. Secondary outcomes included changes in STOP-BANG scores over time before and after treatment. Covariates were divided into age and gender (demographic), type of surgical treatment, and Body Mass Index (physiologic). Data analyses included comparisons of STOP-BANG scores over multiple time points (pre-fracture [T0], post-fracture [T1], 1 week post-surgery [T2], and 1 month post-surgery [T3]). The results were analyzed using SPSS 16 software, with a significance level set at p-value < 0.05.</p><p><strong>Results: </strong>In this study, 154 patients were examined. Ninety-five patients had unilateral fractures and 59 patients had bilateral fractures. The study groups were homogeneous in terms of age, gender, surgical method, and Body Mass Index (BMI). In both unilateral and bilateral groups, the average STOP-BANG score changed significantly over time (p<0.001). Pairwise comparisons indicated that the STOP-BANG score significantly increased at all times compared to pre-fracture, but decreased significantly at each subsequent time point after the fracture. The mean STOP-BANG score was significantly higher in the bilateral group compared to the unilateral group at each time point (T1, T2, T3) (p<0.001). The mean changes in STOP-BANG score relative to T0 were significantly greater in the bilateral group compared to the unilateral group (p<0.001).</p><p><strong>Conclusions: </strong>Mandibular fractures affect respiratory conditions and can lead to OSA. Surgeons should consider the reduction in respiratory space when treating these patients and choose an appropriate treatment plan. Bilateral fractures are more likely to lead to OSA, whereas OSA occurrence was rarely observed in cases of unilateral fractures.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e642-e648"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De-epithelialized free gingival graft versus subepithelial connective tissue graft in the treatment of gingival recession: a systematic review and meta-analysis.","authors":"J-R Tejedo, R-A Jara, L-Z Caceres, A Vergara-Buenaventura, F-W Muniz, M Faveri, J Meza-Mauricio","doi":"10.4317/medoral.27184","DOIUrl":"10.4317/medoral.27184","url":null,"abstract":"<p><strong>Background: </strong>The best technique to harvest gingival graft to treat gingival recessions (GR) remains a topic of ongoing debate. This systematic review aimed to evaluate the effect of de-epithelialized free gingival graft (DFGG) compared to subepithelial connective tissue graft (SCTG) in the treatment of GR Miller Class I and II or Cairo type I.</p><p><strong>Material and methods: </strong>Five databases were searched up to June 2024 to include randomized clinical trials (RCTs) comparing the clinical effects of DFGG with SCTG in the treatment of GR. The random effects model of mean differences was used to determine GR, and gain in keratinized tissue width (KTW), gingival thickness (GT) and clinical attachment level (CAL). The risk ratio was used to complete root coverage (CRC) at 6 and 12 months.</p><p><strong>Results: </strong>Five RCTs including 183 and 111 GR at 6 and 12 months were included in this systematic review. The meta-analysis showed no statistically significant difference in GR reduction, gain in KTW, GT, CRC or CAL between groups at 6 and 12 months.</p><p><strong>Conclusions: </strong>At 12 months, the clinical results of DFGG were similar to those of SCTG in the treatment of GR.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e690-e699"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic melanoma of the major salivary glands - a systematic review.","authors":"P-H Rizzardi, A de Farias Gabriel, I-D Martins, V-C Carrard, V-G Zanella, F-M Girardi, M-A Martins, V-P Wagner, M-D Martins, L-F Schuch","doi":"10.4317/medoral.27216","DOIUrl":"10.4317/medoral.27216","url":null,"abstract":"<p><strong>Background: </strong>Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands.</p><p><strong>Material and methods: </strong>Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included.</p><p><strong>Results: </strong>Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively.</p><p><strong>Conclusions: </strong>Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e736-e744"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppurative Stomatitis [Cheilitis Glandularis]: an underreported entity.","authors":"J-C Panico, B-A Andrade, J Lazos, R Martin, E Piemonte, C-A Lopes, C-H Freire, R-L Panico, G Gilligan","doi":"10.4317/medoral.27138","DOIUrl":"10.4317/medoral.27138","url":null,"abstract":"<p><strong>Background: </strong>Stomatitis and Cheilitis Glandularis are inflammatory conditions of the minor salivary glands with uncertain aetiology, uncommon in clinical practice. Local factors and systemic comorbidities associated with hyposalivation could contribute to the onset of the disease. The aim of this study is to describe retrospectively a case series of Stomatitis and Cheilitis Glandularis from two Oral Medicine and Pathology Departments. Also, a review of the clinical and epidemiological variables and a discussion of the diagnostic criteria is presented.</p><p><strong>Material and methods: </strong>There were included cases of Stomatitis and Cheilitis Glandularis from two Oral Diagnosis Centres from Argentina and Brazil, according to Reiter et al criteria. Demographic and clinicopathological features were described. A concise review of current literature was performed discussing diagnostic criteria and possible etiological factors.</p><p><strong>Results: </strong>There were included six cases sequentially retrieved from the last ten years. The patients included were 4 men and 2 women with an average age of 65.33 years old. The majority of the included cases showed comorbidities or were treated with drugs associated with hyposalivation or a decrease in salivary flow. Clinically, firm nodules and pus discharge was observed in minor salivary glands. Actinic damage was a poorly associated factor in this series. Histopathology revealed sialoadenitis, oncocytic metaplasia with different degrees of periductal inflammation in all cases.</p><p><strong>Conclusions: </strong>Stomatitis and Cheilitis Glandularis are challenging disorders of the oral cavity. Hyposalivation could be an early phenomenon in a multifactorial context. More studies are needed for a better understanding of these conditions.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e664-e672"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Butyrate enhances recovery of chemotherapy-induced oral mucositis by enhancing tight junction protein expression and inhibiting inflammatory responses.","authors":"J Zeng, Z Tan, K Zhang, Q Han, S Ou, Z Wang, J Liu, F Wang, Y Huang, L Wu","doi":"10.4317/medoral.27080","DOIUrl":"10.4317/medoral.27080","url":null,"abstract":"<p><strong>Background: </strong>Chemotherapy-induced oral mucositis (OM) is a common complication of cancer treatment that significantly impacts patients' quality of life. Butyrate, a short-chain fatty acid, has been shown to inhibit inflammation and mitigate intestinal mucosal damage. How, its effect in treating OM remains unclear.</p><p><strong>Material and methods: </strong>OM model in mice pretreated with 5-FU solution was established by injecting 20% acetic acid into oral mucosa. Sodium butyrate was given for treatment. H&E staining was used to observe histopathological changes, and qRT-PCR to assess inflammatory factor level changes in ulcer tissues after treatment. Also, qRT-PCR and immunofluorescence staining were used to evaluate the expression and distribution of tight junction protein in ulcer tissues.</p><p><strong>Results: </strong>Sodium butyrate treatment improved the weight loss in mice caused by OM and promoted the repair of oral mucosa in a time-dependent manner. In addition, sodium butyrate significantly inhibited the mRNA levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-18 (IL-18) in the ulcer tissue. Moreover, sodium butyrate promoted the mRNA and protein expressions of tight junction protein-1 (ZO-1) and Claudin-1 in the epithelial cells of the ulcer tissue.</p><p><strong>Conclusions: </strong>Butyrate promotes OM healing by reducing inflammation and increasing the expression of tight junction proteins in ulcer tissues.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e657-e663"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of simple bone cyst associated within florid cemento-osseous dysplasia: a meta-analysis.","authors":"L Rave, M Rollin, A-L Porporatti, I Taïhi","doi":"10.4317/medoral.27205","DOIUrl":"10.4317/medoral.27205","url":null,"abstract":"<p><strong>Background: </strong>The objectives of this study were to better understand the association between simple bone cysts (SBC) diagnosed within florid cemento-osseous dysplasia (FCOD) by systematically reviewing the literature with a meta-analysis. This review allows us to study the epidemiology, characteristics, treatments, and follow-up of the association between these two entities.</p><p><strong>Material and methods: </strong>A systematic review was performed on PubMed, Scopus, Cochrane library, Embase and Google Scholar. Articles reporting primary studies, case reports and case series were included. We reviewed all articles between 1976 and November 2024. Recorded data were patient's characteristics, clinical and radiological features, diagnosis, treatment, and follow-up. The meta-analysis was performed for the prevalence of the localization of SBC associated FCOD and the number of SBC lesions within FCOD.</p><p><strong>Results: </strong>A total of 615 studies were assessed for eligibility by reading titles and abstracts. Finally, 16 articles were included, with 51 patients presenting SBC associated with FCOD. Patients were mostly women (92%) with most of an African origin (81,25% ). The mean age was 41-year-old. The usual treatment for the cyst was surgical exploration with bleeding stimulation to improve healing. After surgical procedure, a majority of the followed-up cases healed completely (52%) or partially (32%). Eight cases reported a recurrence during the mean follow-up period of 6,6 years.</p><p><strong>Conclusions: </strong>SBC and FCOD are two conditions which can be rarely associated. This may be under-diagnosed as SBC can be misdiagnosed as part of the FCOD lesions. This review highlights the similar clinical characteristics to FCOD which makes important to find out more clinical and radiographic diagnosis criteria to better diagnose and provide the adequate treatment to obtain bone healing.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e709-e720"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of regulatory and executor proteins of apoptosis in odontogenic keratocyst: a systematic review.","authors":"R Martínez-Flores, M Muñoz-Orrego, C Marín-Márquez, L-F Schuch, F-M Silveira, R Bologna-Molina, S-E Niklander","doi":"10.4317/medoral.26973","DOIUrl":"10.4317/medoral.26973","url":null,"abstract":"<p><strong>Background: </strong>The odontogenic keratocyst (OKC) corresponds to the third most common odontogenic cyst of the maxillary bones, originating from the dental lamina or its remnants. Apoptosis dysregulation, due to an imbalance between anti-apoptotic and proapoptotic proteins, has been proposed as a promoter for the development and progression of OKC. This study aimed to conduct a systematic review to synthesize the current knowledge on effector proteins of the intrinsic and extrinsic pathways, and executor proteins of apoptosis in OKC and compare their expression to other odontogenic cysts and tumors.</p><p><strong>Material and methods: </strong>Primary studies were searched in PubMed, Scopus, and Web of Science databases, following the recommendations of PRISMA. Inclusion criteria were articles in English reporting the expression of at least two apoptosis-related proteins in OKC, studies using human tissues, descriptive retrospective case series, or in vitro assays.</p><p><strong>Results: </strong>Seven articles met the inclusion criteria and were considered for data extraction and analysis. Of the selected articles, six studied proteins related to the regulation of the intrinsic pathway of apoptosis, all reporting the immunohistochemical expression of Bcl-2 and BAX. Only one study reported the immunohistochemical expression of proteins related to the regulation of the extrinsic pathway, specifically Fas and FasL. Regarding apoptosis execution proteins, only one article characterized the immunohistochemical expression of caspases, specifically caspase-3.</p><p><strong>Conclusions: </strong>OKC expresses proteins related to apoptosis regulation similar to other aggressive odontogenic lesions, such as ameloblastoma. This suggests that apoptosis dysregulation may be essential in its development and progression.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e632-e641"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis associated with prostate cancer and other urological cancers in patients over 50 years of age: a cross-sectional study.","authors":"A-A Ajalcriña-Martensen, C-A Minchón-Medina, J Astigueta-Perez, W-G Gamboa-Vicente, L-J Ganoza-Larrea, A-S Asmat-Abanto","doi":"10.4317/medoral.27179","DOIUrl":"10.4317/medoral.27179","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50.</p><p><strong>Material and methods: </strong>This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases \"Dr. Luis Pinillos Ganoza\" - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05.</p><p><strong>Results: </strong>An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012).</p><p><strong>Conclusions: </strong>There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e681-e689"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of actin cytoskeleton organization genes in oral cancer and oral potentially malignant disorders using oral tissue RNA-seq database.","authors":"M Serna-García, A Formaggio, M-C Carceller, J-J Romero, N Flacco","doi":"10.4317/medoral.27364","DOIUrl":"https://doi.org/10.4317/medoral.27364","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer and oral potentially malignant disorders (leukoplakia and oral submucous fibrosis) are prevalent and clinically significant oral diseases. Actin, crucial for epithelial tissue integrity, undergoes cytoskeleton reorganization associated with increased invasiveness in oral cancer.</p><p><strong>Material and methods: </strong>Bioinformatic analysis of RNA-seq data from GEO public databases was performed to detect differentially expressed genes in oral cancer, leukoplakia and oral submucous fibrosis. Enrichment analysis of the differentially expressed genes was performed using DAVID and GSEA softwares. ROC curve and survival analysis were conducted to assess the discriminative capacity of these genes as possible biomarkers. The results were further validated using RNAseq data from The Cancer Genome Atlas (TCGA).</p><p><strong>Results: </strong>EPRS1 was consistently overexpressed in all three pathologies. Key genes (ACTIN1, LIMK1, CORO1C, INF2, SH3D21, CFL1, FSCN1, MYO1B) implicated in actin cytoskeleton organization were identified, suggesting their role in oral potentially malignant disorders and cancer progression. Receiver operating characteristic (ROC) curves on 522 TCGA samples demonstrated these genes' potential as early biomarkers for oral cancer, with their inhibition associated with improved survival.</p><p><strong>Conclusions: </strong>The identified genes offer insights into actin-related mechanisms and potential pathways for the diagnosis and treatment of oral cancer. Nonetheless, further research is essential to validate these results.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological evolution of gingival cancer in Spain from 2001 to 2022: a longitudinal study.","authors":"J Celis-Dooner, M-C Mateo-Sidrón-Antón, R Cerero-Lapiedra, L-A Moreno-López","doi":"10.4317/medoral.27465","DOIUrl":"https://doi.org/10.4317/medoral.27465","url":null,"abstract":"<p><strong>Background: </strong>Over the past decades, the literature has described epidemiological changes in oral cancer. However, few updated studies specifically address this issue, particularly those examining it separately from pharyngeal cancer. Some authors suggest gingival cancer is the only intraoral cancer with a higher prevalence among women.</p><p><strong>Material and methods: </strong>A retrospective longitudinal study was conducted using the Specialized Care Activity Registry from the Minimum Basic Data Set to obtain data on gingival cancer patients in Spain from 2001 to 2022.</p><p><strong>Results: </strong>Data from 5,749 patients showed 51.8% were men and 48.2% women. A final predominance in women was observed. The average recorded age was 68.3 years, increasing in both sexes over time. A low frequency of tobacco and alcohol consumption was noted. The age-adjusted incidence was 0.61, with a convergence between sexes due to increased female incidence.</p><p><strong>Conclusions: </strong>During the study period, a reversal in the male-to-female ratio was observed, along with an increase in recorded age, a preference for the mandible over the maxilla, low tobacco and alcohol consumption, and incidence convergence between sexes due to rising female cases.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}