{"title":"Oral leukoplakia: still an enigmatic disorder.","authors":"J-M Aguirre-Urizar","doi":"10.4317/medoral.27214","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oral leukoplakia is the most frequent and representative potentially malignant disorder of what is known as oral precancer. Since the first descriptions, this pathology, which initially seems simple, has been the subject of controversy and discussion, and it still maintains multiple unknowns and enigmas to be solved.</p><p><strong>Material and methods: </strong>A narrative and integrative review of the epidemiological, pathogenetic, diagnostic, prognostic and therapeutic aspects of this important oral disorder has been carried out.</p><p><strong>Results: </strong>Oral leukoplakia still presents multiple enigmas regarding its actual epidemiology, its multifactorial and multistage pathogenesis, its definition and diagnosis, its malignant development and its treatment.</p><p><strong>Conclusions: </strong>We must conduct well-designed prospective studies on this fascinating oral pathology, on well-diagnosed clinical cases with clinicopathological criteria agreed and accepted by the scientific community. Only in this way will we be able to clarify the enigmas it still presents.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Oral Patologia Oral Y Cirugia Bucal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4317/medoral.27214","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Oral leukoplakia is the most frequent and representative potentially malignant disorder of what is known as oral precancer. Since the first descriptions, this pathology, which initially seems simple, has been the subject of controversy and discussion, and it still maintains multiple unknowns and enigmas to be solved.
Material and methods: A narrative and integrative review of the epidemiological, pathogenetic, diagnostic, prognostic and therapeutic aspects of this important oral disorder has been carried out.
Results: Oral leukoplakia still presents multiple enigmas regarding its actual epidemiology, its multifactorial and multistage pathogenesis, its definition and diagnosis, its malignant development and its treatment.
Conclusions: We must conduct well-designed prospective studies on this fascinating oral pathology, on well-diagnosed clinical cases with clinicopathological criteria agreed and accepted by the scientific community. Only in this way will we be able to clarify the enigmas it still presents.
期刊介绍：
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology
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