Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Oral cancer awareness and knowledge among patients attending an oncological screening program in Portugal.","authors":"M Andrade, D Pereira, B Garcia, A Moreira, J Caramês, M Pojo, F Freitas","doi":"10.4317/medoral.27081","DOIUrl":"10.4317/medoral.27081","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the awareness and knowledge about oral cancer in a Portuguese population and to assess its possible relations with sociodemographic variables.</p><p><strong>Material and methods: </strong>A cross-sectional questionnaire survey was conducted, with 2650 individuals that attended oncological screening initiatives in the southern region of Portugal. The questionnaire collected data on participants' socio-demographic information, life-style habits, and awareness of oral cancer.</p><p><strong>Results: </strong>Over four-fifths of the participants (83.4%) mentioned that had already heard about oral cancer. Knowledge of oral cancer was significantly associated with age (p = 0.034), education level (p < 0.001), frequency of dentist visits (p < 0.001), and smoking (p = 0.015) and alcohol habits (p = 0.031). Regarding risk factors, smoking and alcohol usage were identified by 86% and 58.5% of the sample, respectively. Only 62.8%, 45.5%, and 37.9%, respectively, were able to correctly identify ulcers that don't heal, red and white lesions, and lumps/tissue that overgrows as early signs of oral cancer.</p><p><strong>Conclusions: </strong>A general lack of awareness regarding oral cancer was found in this Portuguese population. Lower levels of knowledge were found in individuals of higher risk for oral cancer. Therefore, educational programs targeting the risk population are highly recommended for the primary prevention and early diagnosis of oral cancer in the Portuguese population.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e543-e550"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years.","authors":"C Li, Z Gong, S Jumatai, C Fang, P Pataer, H Zhao","doi":"10.4317/medoral.27164","DOIUrl":"10.4317/medoral.27164","url":null,"abstract":"<p><strong>Background: </strong>Osteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aimed to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario.</p><p><strong>Material and methods: </strong>A cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020. A total of 106 patients were divided into normal wound healing group (n = 79) and delayed wound healing group (n = 27) according to two different prognosis. The risk factors associated with the prognosis in patients with ORNJ were comparatively analyzed via performing one-way and multifactorial logistic analyses.</p><p><strong>Results: </strong>The majority of the study cohort (n = 59, 55.7%) was found to be characterized with Glanzmann and Gratz grade 2 and followed up for a median of 38.6 months. Diabetes mellitus (P = .045), Charlson comorbidity index (P = .042), American Society of Anesthesiologists score (P < .001), primary tumour site (P = .012), T stage (P = .008), ORNJ grade at initial diagnosis (P < .001), pan-immune-inflammatory value and systemic immune-inflammatory index at initial radiotherapy (P = .01 and P < .001 respectively) were detected as risk factors associated with poor prognosis in patients with ORNJ.</p><p><strong>Conclusions: </strong>We conclude that there are abundant risk factors for poor prognosis in these patients, and it is important to be evaluated before irradiation so that suitable post-radiated treatments can be given.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e597-e604"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel approach in the resection of oral maxillary tumours.","authors":"P Cea-Arestín, A Bilbao-Alonso, A García-García, C Menéndez-Lago","doi":"10.4317/medoral.27046","DOIUrl":"10.4317/medoral.27046","url":null,"abstract":"<p><strong>Background: </strong>Oral cavity tumours represent a global oral health issue due to their prevalence and incidence, in this paper, we will explain the procedure for the removal of various tumours and the restoration of the patient's anatomy, function and aesthetics through a novel approach that rely on a temporal muscle flap for the reconstruction of soft tissues in the surgical area.</p><p><strong>Material and methods: </strong>This study is based on an analysis of temporal flap technique data, collected at the public health hospital of Santiago de Compostela (CHUS), from 2015 to 2024.</p><p><strong>Results: </strong>The results are shown in table 1, being the most relevant data the fact of having a series of 11 successful cases treated with temporal flap. The surgical technique involves tumor resection, preferably through an intraoral approach.</p><p><strong>Conclusions: </strong>This novel technique must be taken into account when solving this type of oncological cases with associated maxillectomy due to it's better results in terms of reconstruction of tissues and anatomy, shorter execution time and possibility of offering immediate function to the patient, leading to less number of surgeries with their consequent lower morbidity and social-health and economic savings.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e520-e522"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival rate and marginal bone loss in titanium vs titanium-zirconia single-unit narrow diameter implants. A systematic review and Meta-analysis of prospective studies.","authors":"J-F Peña-Cardelles, S Akhondi, J Markovic, K Pala, A Lanis, G-O Gallucci","doi":"10.4317/medoral.27042","DOIUrl":"10.4317/medoral.27042","url":null,"abstract":"<p><strong>Background: </strong>Implant-supported single-unit restorations present a predictable and widely used treatment option to replace missing teeth. Narrow-diameter implants provide a viable treatment option for clinical scenarios with limited bone availability, minimizing the need for bone augmentation procedures. This systematic review aims to assess implant survival and implant marginal bone loss among different single-unit narrow implant diameters and between titanium single-unit and titanium-zirconia single-unit narrow implants.</p><p><strong>Material and methods: </strong>This article was structured according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA®) Included criteria were randomized clinical trials (RCTs) and clinical prospective studies with at least 10 patients, a mean follow-up period of at least 12 months, and assessing single-tooth implants with a diameter of 3.5 mm or less.</p><p><strong>Results: </strong>Twelve included articles were prospective clinical studies, while 3 articles were randomized controlled clinical studies. There are no significant differences in the comparison between the 2.9-3.0 mm group and the 3.3-3.5 mm group (p=0.933). Both groups had a 99% survival (95% CI, 99.9%-100%). Titanium-zirconia implants presented a mean of marginal bone loss of -0,37 mm (CI, 95%: -0,53 to -0,20) meanwhile, titanium implants had a mean of marginal bone loss of -0,43 mm (CI95%:-0,71 to -0,28).</p><p><strong>Conclusions: </strong>The findings reveal no significant differences between 2.9-3.3mm and 3.3-3.5mm groups within narrow implants. Both titanium and titanium-zirconia alloys in narrow implants, exhibit comparable high survival rates and minimal marginal bone loss, showcasing their feasibility as a viable treatment alternative in scenarios with limited space or inadequate bone for regular diameter implants.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e499-e511"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of language models in addressing syphilis-related queries.","authors":"L-M Ferreira, J-P Nascimento, L-L Souza, F-T Souza, L-D Guimarães, M-A Lopes, P-A Vargas, H Martelli-Júnior","doi":"10.4317/medoral.27092","DOIUrl":"10.4317/medoral.27092","url":null,"abstract":"<p><strong>Background: </strong>Syphilis, caused by Treponema pallidum, is a significant global health concern with potentially severe complications if untreated. Advances in artificial intelligence (AI), particularly large language models (LLMs), offer opportunities to enhance medical diagnosis and public health education. This study aims to assess LLMs' ability to provide readable, accurate, and comprehensive syphilis information by comparing it with WHO datasheets and validating through specialist evaluation for clinical relevance.</p><p><strong>Material and methods: </strong>Ten AI-based LLMs were evaluated. Ten questions addressing symptoms, transmission, diagnosis, treatment, and prevention were crafted by researchers. Responses from the LLMs were compared to World Health Organization (WHO) syphilis fact sheets, and a panel of specialists assessed the accuracy, clinical relevance, and readability of the AI-generated information.</p><p><strong>Results: </strong>Among the evaluated LLMs, ChatGPT 4.0 and Claude demonstrated the highest accuracy, scoring 92% and 89% alignment with WHO standards, respectively. Perplexity and Llama3 performed less reliably, with scores between 60-70%, especially in areas like tertiary syphilis and neurosyphilis. Specialists identified common errors, such as outdated treatment protocols and incorrect descriptions of transmission pathways. Expert reviews further revealed that while LLMs provided adequate information on early syphilis symptoms, they struggled with complex clinical nuances. The specialists' evaluation showed that only 60% of the AI-generated content was deemed clinically reliable without further edits, with ChatGPT 4.0 rated highest by experts in terms of readability and clinical accuracy.</p><p><strong>Conclusions: </strong>LLMs hold promise for disseminating syphilis information, but human oversight is crucial. AI models need refinement to improve their accuracy, especially in complex medical scenarios.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e551-e560"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigeminocardiac reflex in bimaxillary orthognathic surgery: case review.","authors":"L Ortiz-Peces, M Álvaro-Martínez, Á-D Moreiras-Sánchez, G Chacón-Ferrer, M Andura-Correas, J-L Castillo-Pardo de Vera, L Ortiz-González, J-L Cebrián-Carretero","doi":"10.4317/medoral.27062","DOIUrl":"10.4317/medoral.27062","url":null,"abstract":"<p><strong>Background: </strong>The trigeminocardiac reflex (TCR) is a rare but clinically significant phenomenon characterized by bradycardia, hypotension, or asystole triggered by trigeminal nerve stimulation during maxillofacial surgery. It necessitates prompt recognition and management to ensure patient safety. TCR has been reported in orthognathic surgery, particularly during specific surgical maneuvers.</p><p><strong>Material and methods: </strong>We report the case of a 36-year-old male who experienced TCR during bimaxillary orthognathic surgery. Detailed documentation of the patient's clinical characteristics, intraoperative events, and management strategies was included. Additionally, we conducted a systematic review of the literature using Medline, Embase, Web of Science, and Scopus databases to identify cases of TCR in orthognathic surgery published from 1989 onward. Keywords included \"trigeminocardiac reflex,\" \"orthognathic surgery,\" \"Le Fort I,\" and \"bilateral sagittal split osteotomy\".</p><p><strong>Results: </strong>We present the case of a patient who experienced transient bradycardia and asystole during mandibular manipulation and pterygomaxillary disjunction. The episode was successfully managed with atropine and cessation of triggering maneuvers. Additionally, a systematic review identified 10 cases of TCR in orthognathic surgery, most of which occurred during Le Fort I osteotomies, particularly during maxillary downfracture, followed by bilateral sagittal split osteotomies. Common manifestations included bradycardia and asystole. Management strategies involved cessation of surgical stimuli, administration of anticholinergic agents, and, in one severe case, cardiopulmonary resuscitation.</p><p><strong>Conclusions: </strong>TCR in orthognathic surgery is a significant risk requiring vigilance and prompt management. Understanding its triggers, maintaining intraoperative monitoring, and employing preventive strategies, such as gentle manipulation and proper anesthesia protocols, are essential for optimizing patient safety.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e523-e527"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ultrasonographic features of major salivary glands and oral manifestations in patients with Sjögren's Syndrome.","authors":"B Taşkın, D Göller-Bulut, M Taşçı","doi":"10.4317/medoral.27180","DOIUrl":"10.4317/medoral.27180","url":null,"abstract":"<p><strong>Background: </strong>Sjögren's Syndrome (SS) is an autoimmune disease characterized by the involvement of exocrine glands and leading to various oral manifestations. The present study aimed to investigate the relationships between the salivary glands' ultrasonographic findings, the frequency of oral manifestations, the DMFT index and the unstimulated salivary flow rate in patients diagnosed with SS and to compare these parameters with healthy controls.</p><p><strong>Material and methods: </strong>The ultrasonographic findings of the parotid and submandibular glands in 43 patients with SS were evaluated according to the Hocevar and Milic scoring system. The frequency of oral manifestations, the unstimulated salivary flow rate, and the DMFT index were calculated and the relationships between these parameters were examined. The ultrasonography findings and the DMFT index ​​of SS patients were compared with the 43 healthy control group.</p><p><strong>Results: </strong>The total Hocevar and Milic scores were higher in the patients than in the controls (p<0.05). The submandibular gland Hocevar score, the DMFT index, the frequency of burning mouth, and stomatitis were higher in patients with salivary flow rate ≤0.1 ml/min (p<0.05). Hocevar and Milic total scores were lower in patients with a salivary flow rate>0.1 ml/min. A positive correlation was observed between ultrasonography scores and DMFT in the patients (p<0.05). The mean total Hocevar score was found to be higher in submandibular gland than in the parotid gland (p=0.042).</p><p><strong>Conclusions: </strong>The increase in salivary gland ultrasonography scores in SS correlated with a decrease in unstimulated salivary flow rate, an increase in the DMFT index and some oral manifestations. Ultrasonography scores showed that, in the early stages of SS, the submandibular gland parenchyma was more affected than the parotid gland. The diagnosis of SS is difficult, and dentists can play an important role in the early diagnosis of the disease by evaluating the oral manifestations and ultrasonography findings.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e614-e624"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myofibromas of the jawbones in pediatric patients. A clinicopathological study.","authors":"G-C Barajas-Torres, N-L Villanueva-Moreno, H Rincón-Rodríguez, V Cuairán-Ruidiaz, H Márquez-González, J-R Murillo-Eliosa, A Mosqueda-Taylor","doi":"10.4317/medoral.27021","DOIUrl":"10.4317/medoral.27021","url":null,"abstract":"<p><strong>Background: </strong>Myofibromas are infrequent neoplasms that rarely occur in the jawbones. The aim of this study is to present a series of cases of these tumors affecting the jawbones in pediatric patients, as well as to describe their diagnostic methodology and therapeutic approach.</p><p><strong>Material and methods: </strong>retrospective study of a series of myofibromas of the jawbones diagnosed and treated in a single medical institution in Mexico City from 2002-2022.</p><p><strong>Results: </strong>There were 14 cases with a median age of 6.5 years (IQR:1-12). Mandible was affected in 8 cases (57.1%), maxilla in 5 (35.8%) and only one case (7.1%) occurred in both jaws. Microscopically, the lesions were composed predominantly by spindle cells, as well as stellate and sometimes pleomorphic in shape, most of which were positive for smooth muscle actin. All cases were treated with complete excision of the lesion and only one presented recurrence.</p><p><strong>Conclusions: </strong>Once the diagnosis is confirmed and other spindle cell neoplasms have been excluded, resection with free margins represents the treatment of choice.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e476-e483"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is lingual fracture pattern in sagittal split osteotomy associated with recovery of neurosensory disturbance?","authors":"Y-N Kaba, C Eren, A-E Demirbas, B-G Yaşar, E Soylu, N Gayıbov","doi":"10.4317/medoral.27136","DOIUrl":"10.4317/medoral.27136","url":null,"abstract":"<p><strong>Background: </strong>Bilateral sagittal split osteotomy (BSSO) is commonly used to correct mandibular deformities but may cause neurosensory disturbance (NSD) of the lower lip due to potential injury to the inferior alveolar nerve (IAN). The purpose of this study was to evaluate the effect of LSS 3 on postoperative neurosensory disturbances. The hypothesis of this study was that the LSS 3 split pattern would extend the recovery time of neurosensory disturbance.</p><p><strong>Material and methods: </strong>The retrospective cohort study included patients who underwent BSSO surgery in Erciyes University, Oral and Maxillofacial Surgery Hospital. The primary predictor variable was the lingual split pattern. The split patterns were categorized using the Lingual Split Scale (LSS). The primary outcome was NSD. The postoperative sensation was assessed using a visual analogue scale (VAS). The secondary outcome was intraoperative nerve exposure. The nerve exposure was classified as No nerve encountered, Embedded in distal segment, Embedded in proximal segment and Nerve transected. All data were analyzed using Turcosa Cloud statistical software (Turcosa Ltd. Co., Turkey). p<0.05 was considered significant.</p><p><strong>Results: </strong>The study included 101 patients with 202 split sides. LSS 1 was the most common pattern (63.37%), followed by LSS 3 (25.74%). In LSS 3 split pattern, the inferior alveolar nerve mostly embedded in the proximal segment (p<0.05). NSD was highest in LSS 3 cases, particularly in the first 6 months postoperatively (p<0.05). However, no significant differences were observed after 12 months.</p><p><strong>Conclusions: </strong>LSS 3 splits may significantly increase embedded in the proximal segment and can associated with higher postoperative NSD, particularly in the first 6 months. Surgeons should consider factors contributing to LSS 3 patterns to reduce the risk of NSD.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e590-e596"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis as a risk factor for colorectal cancer: systematic review and meta-analysis.","authors":"R-E Espejo-Carrera, T-M Honores-Solano, T-V Ulloa-Cueva, J-A Caballero-Alvarado, C-A Minchón-Medina, A-S Asmat-Abanto","doi":"10.4317/medoral.27118","DOIUrl":"10.4317/medoral.27118","url":null,"abstract":"<p><strong>Background: </strong>Primary studies on the association between periodontitis and colorectal cancer (CRC) may have insufficient statistical power to reach a reliable conclusion. In this regard, the present systematic review and meta-analysis were conducted to determine whether periodontitis is a risk factor for CRC.</p><p><strong>Material and methods: </strong>A systematic search was carried out in five databases, which included cohort and case-control studies published up to July 3, 2024, in which periodontitis was evaluated as a risk factor for CRC using relative risk (RR), hazard ratio (HR) or odds ratio (OR). The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias, and the GRADE system was used to determine the certainty of the evidence.</p><p><strong>Results: </strong>Of 1476 articles retrieved, 8 cohort studies were included for qualitative analysis and meta-analysis. The overall synthesis showed that periodontitis is not a risk factor for CRC (RR=1.34; 95% CI: 0.96-1.89; p<0.09; I2=95%). In addition, subgroup analyses were performed according to gender, periodontitis diagnostic methods, and risk of bias, which led to the finding of an increased risk of CRC of 32% only for men with periodontitis (RR=1.32; 95% CI: 1.16-1.50; p<0.00001; I2=0%).</p><p><strong>Conclusions: </strong>Periodontitis is not a risk factor for CRC, with very low certainty of evidence. However, the analysis of subgroups by gender showed that it is a risk factor for CRC in men, with moderate certainty of evidence.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e568-e577"},"PeriodicalIF":1.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}