Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years.","authors":"C Li, Z Gong, S Jumatai, C Fang, P Pataer, H Zhao","doi":"10.4317/medoral.27164","DOIUrl":"https://doi.org/10.4317/medoral.27164","url":null,"abstract":"<p><strong>Background: </strong>Osteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aimed to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario.</p><p><strong>Material and methods: </strong>A cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020. A total of 106 patients were divided into normal wound healing group (n = 79) and delayed wound healing group (n = 27) according to two different prognosis. The risk factors associated with the prognosis in patients with ORNJ were comparatively analyzed via performing one-way and multifactorial logistic analyses.</p><p><strong>Results: </strong>The majority of the study cohort (n = 59, 55.7%) was found to be characterized with Glanzmann and Gratz grade 2 and followed up for a median of 38.6 months. Diabetes mellitus (P = .045), Charlson comorbidity index (P = .042), American Society of Anesthesiologists score (P < .001), primary tumour site (P = .012), T stage (P = .008), ORNJ grade at initial diagnosis (P < .001), pan-immune-inflammatory value and systemic immune-inflammatory index at initial radiotherapy (P = .01 and P < .001 respectively) were detected as risk factors associated with poor prognosis in patients with ORNJ.</p><p><strong>Conclusions: </strong>We conclude that there are abundant risk factors for poor prognosis in these patients, and it is important to be evaluated before irradiation so that suitable post-radiated treatments can be given.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of language models in addressing syphilis-related queries.","authors":"L-M Ferreira, J-P Nascimento, L-L Souza, F-T Souza, L-D Guimarães, M-A Lopes, P-A Vargas, H Martelli-Júnior","doi":"10.4317/medoral.27092","DOIUrl":"https://doi.org/10.4317/medoral.27092","url":null,"abstract":"<p><strong>Background: </strong>Syphilis, caused by Treponema pallidum, is a significant global health concern with potentially severe complications if untreated. Advances in artificial intelligence (AI), particularly large language models (LLMs), offer opportunities to enhance medical diagnosis and public health education. This study aims to assess LLMs' ability to provide readable, accurate, and comprehensive syphilis information by comparing it with WHO datasheets and validating through specialist evaluation for clinical relevance.</p><p><strong>Material and methods: </strong>Ten AI-based LLMs were evaluated. Ten questions addressing symptoms, transmission, diagnosis, treatment, and prevention were crafted by researchers. Responses from the LLMs were compared to World Health Organization (WHO) syphilis fact sheets, and a panel of specialists assessed the accuracy, clinical relevance, and readability of the AI-generated information.</p><p><strong>Results: </strong>Among the evaluated LLMs, ChatGPT 4.0 and Claude demonstrated the highest accuracy, scoring 92% and 89% alignment with WHO standards, respectively. Perplexity and Llama3 performed less reliably, with scores between 60-70%, especially in areas like tertiary syphilis and neurosyphilis. Specialists identified common errors, such as outdated treatment protocols and incorrect descriptions of transmission pathways. Expert reviews further revealed that while LLMs provided adequate information on early syphilis symptoms, they struggled with complex clinical nuances. The specialists' evaluation showed that only 60% of the AI-generated content was deemed clinically reliable without further edits, with ChatGPT 4.0 rated highest by experts in terms of readability and clinical accuracy.</p><p><strong>Conclusions: </strong>LLMs hold promise for disseminating syphilis information, but human oversight is crucial. AI models need refinement to improve their accuracy, especially in complex medical scenarios.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials.","authors":"C-M Mesquita, A-C Diniz, S-P Sakamoto, W-A Vieira, R-B Brito-Junior, M-D Costa, L-R Paranhos","doi":"10.4317/medoral.27260","DOIUrl":"https://doi.org/10.4317/medoral.27260","url":null,"abstract":"<p><strong>Background: </strong>Orthognathic surgery is a complex invasive procedure associated with common postoperative symptoms and patient-related events. Dexmedetomidine is an emerging sedative and hypotensive agent that has demonstrated safety and efficacy in perioperative care of other craniofacial procedures.</p><p><strong>Material and methods: </strong>An electronic search was performed in seven primary databases (Cochrane Library, Embase, LILACS, MedLine via PubMed, SciELO, Scopus, and Web of Science) and one additional (EASY) to partially capture the gray literature. The PICO strategy was used to identify randomized clinical trials evaluating the effect of dexmedetomidine on perioperative events in patients undergoing orthognathic surgery compared to placebo or control groups, without restrictions on publication language and year. Two independent reviewers performed data extraction and assessed the risk of bias using the RoB 2.0 tool.</p><p><strong>Results: </strong>The search identified 401 records, of which six studies met the eligibility criteria, including 282 patients from five countries, and published between 2008 and 2023. Outcomes were categorized into six groups based on available data: 1) Airway and Respiratory Events, 2) Emetic Events, 3) Hemodynamic Events, 4) Length of Hospital Stay, 5) Neurological Events, and 6) Pain Burden. Dexmedetomidine reduced coughing and maintained hemodynamic stability but did not prevent emergence agitation. It was associated with lower intraoperative fentanyl use and reduced rescue analgesia requirements. Postoperatively, dexmedetomidine effectively controlled pain, nausea, and vomiting, with significantly lower pain scores and reduced analgesic demand. Among the six studies, only one was classified as high risk of bias due to issues in the randomization process, while the others were categorized as low risk of bias. A meta-analysis was planned but could not be conducted due to high heterogeneity among studies.</p><p><strong>Conclusions: </strong>Dexmedetomidine appears to be a safe and effective option for reducing postoperative symptoms such as pain, nausea, vomiting, and cough in orthognathic surgery, while maintaining hemodynamic stability.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ultrasonographic features of major salivary glands and oral manifestations in patients with Sjögren's Syndrome.","authors":"B Taşkın, D Göller-Bulut, M Taşçı","doi":"10.4317/medoral.27180","DOIUrl":"https://doi.org/10.4317/medoral.27180","url":null,"abstract":"<p><strong>Background: </strong>Sjögren's Syndrome (SS) is an autoimmune disease characterized by the involvement of exocrine glands and leading to various oral manifestations. The present study aimed to investigate the relationships between the salivary glands' ultrasonographic findings, the frequency of oral manifestations, the DMFT index and the unstimulated salivary flow rate in patients diagnosed with SS and to compare these parameters with healthy controls.</p><p><strong>Material and methods: </strong>The ultrasonographic findings of the parotid and submandibular glands in 43 patients with SS were evaluated according to the Hocevar and Milic scoring system. The frequency of oral manifestations, the unstimulated salivary flow rate, and the DMFT index were calculated and the relationships between these parameters were examined. The ultrasonography findings and the DMFT index ​​of SS patients were compared with the 43 healthy control group.</p><p><strong>Results: </strong>The total Hocevar and Milic scores were higher in the patients than in the controls (p<0.05). The submandibular gland Hocevar score, the DMFT index, the frequency of burning mouth, and stomatitis were higher in patients with salivary flow rate ≤0.1 ml/min (p<0.05). Hocevar and Milic total scores were lower in patients with a salivary flow rate>0.1 ml/min. A positive correlation was observed between ultrasonography scores and DMFT in the patients (p<0.05). The mean total Hocevar score was found to be higher in submandibular gland than in the parotid gland (p=0.042).</p><p><strong>Conclusions: </strong>The increase in salivary gland ultrasonography scores in SS correlated with a decrease in unstimulated salivary flow rate, an increase in the DMFT index and some oral manifestations. Ultrasonography scores showed that, in the early stages of SS, the submandibular gland parenchyma was more affected than the parotid gland. The diagnosis of SS is difficult, and dentists can play an important role in the early diagnosis of the disease by evaluating the oral manifestations and ultrasonography findings.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of leukocyte- and platelet-rich fibrin in the treatment and prevention of medication-related osteonecrosis of the jaw: a prospective study.","authors":"A Medeiros-Monzón, A Blanco-Carrión, P Gándara-Vila, G-C Camolesi, A Pérez-Jardón, A-I Lorenzo-Pouso, M Pérez-Sayáns","doi":"10.4317/medoral.27249","DOIUrl":"https://doi.org/10.4317/medoral.27249","url":null,"abstract":"<p><strong>Introduction: </strong>Medication-related osteonecrosis of the jaws (MRONJ) is a serious condition associated with bone modifying agents (BMAs) intake, leading to impaired bone healing and increased morbidity. Despite various therapeutic approaches, an optimal treatment strategy remains elusive. Leukocyte- and Platelet- Rich fibrin (L-PRF) has emerged as a promising autologous biomaterial due to its regenerative properties. This study aimed to evaluate the efficacy of L-PRF in the treatment and prevention of MRONJ.</p><p><strong>Material and methods: </strong>A prospective cohort study was conducted, including a total of 30 patients diagnosed with MRONJ (stage I or II) or at risk of developing it (non-MRONJ). Patient underwent standardized treatment involving surgical debridement followed by L-PRF application. Clinical and demographic data were collected, and healing outcomes were assessed at multiple follow-up intervals (7 days, 14 days, 1 month, 3 months and 6 months). Statistical analyses, including Kaplan-Meier survival estimates, were performed to evaluate treatment effectiveness.</p><p><strong>Results: </strong>The study demonstrated an overall healing of 90%, with a complete recovery in 82.4% of confirmed MRONJ cases and 100% of at-risk patients. L-PRF exhibited good clinical outcomes, including reduced inflammation and pain, accelerated epithelialization, and improved tissue regeneration. The median healing time was estimated at 33.41 days for MRONJ patients and 11.00 for non-MRONJ. No significant differences in healing rates were observed based on age, sex, or systemic conditions.</p><p><strong>Conclusions: </strong>L-PRF represents a promising adjunct in MRONJ management, improving healing outcomes and postoperative recovery. Its autologous nature and growth factor release enhance bone regeneration, suggesting its potential as both a therapeutic and preventive strategy. Further larger-scale clinical trials are needed to standardize protocols and validate long-term efficacy.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the stresses on pterygoid and zygomatic implants used in atrophic maxilla rehabilitation by finite element analysis.","authors":"U Bakay, B Gulsun, R Guler","doi":"10.4317/medoral.27199","DOIUrl":"https://doi.org/10.4317/medoral.27199","url":null,"abstract":"<p><strong>Background: </strong>This study aims to compare stresses from vertical and oblique forces on pterygoid and zygomatic implants, combined with dental implants, in a atrophic maxilla using finite element stress analysis.</p><p><strong>Material and methods: </strong>A computed tomography scan was used to create a geometric model of a completely edentulous adult maxilla. The maxillary bone was scanned using cone beam computed tomography (ILUMA, Orthocad, CBCT, 3M Imtec, Oklahoma, USA), and the obtained sections were transferred to the 3D-Doctor (Able Software Corp., MA, USA) software. Two models were created in the study. In the first model, zygomatic and dental implants were used, while in the second model, pterygoid and dental implants were used. A 150 N vertical force and a 100 N oblique force at a 30-degree buccolingual angle were applied. With finite element analysis assessed stress distribution in the implants and peri-implant bone tissue.</p><p><strong>Results: </strong>When the obtained stress data were examined, under vertical forces, the maximum stress on the implants was higher in Model 1 (151.984 MPa) compared to Model 2 (151.773 MPa), but no significant difference was observed. The stress formed in the metal substructure was higher in Model 2 (422.042 MPa) compared to Model 1 (308.376 MPa). The maximum principal stress in the alveolar bone was greater in Model 2 (46.866 MPa) compared to Model 1 (15.719 MPa), and the minimum principal stress in the alveolar bone was also greater in Model 2 (80.360 MPa) compared to Model 1 (76.310 MPa). Under oblique forces, the average stress on the implants was higher in Model 2 (128.297 MPa) than in Model 1 (79.607 MPa).</p><p><strong>Conclusions: </strong>When the stresses occurring on zygomatic and pterygoid implants and the alveolar bone surrounding these implants were compared, it was observed that the use of zygomatic implants was more beneficial in reducing both dental and biomechanical stress.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for rehabilitation management with implants in patients with down syndrome: a scoping review.","authors":"J Dethlefs-Canto, S Baeza-Vallejos, D Ormeño-Sepúlveda, A Bustos-Ponce","doi":"10.4317/medoral.27093","DOIUrl":"https://doi.org/10.4317/medoral.27093","url":null,"abstract":"<p><strong>Background: </strong>Down Syndrome (DS), caused by an extra chromosome 21, has a prevalence of 24.7 per 10,000 live births in Chile, the highest in Latin America. Individuals with DS commonly present orofacial and dental anomalies, complicating oral health management. Many depend on removable prostheses, which represent challenges in hygiene, handling, and adaptation. Dental implants are a promising alternative, offering improved stability and functionality. However, successful rehabilitation requires addressing specific anatomical, physiological, and behavioral considerations. This scoping review compiles evidence-based strategies to guide implant treatment in this population.</p><p><strong>Material and methods: </strong>Registered on the Open Science Framework (https://osf.io/bstwk/), this review followed the PRISMA-ScR protocol, addressing the question: \"Which are the management strategies and survival rates of dental implants in patients with Down Syndrome?\" Searches were conducted in Pubmed/MEDLINE, Scopus, Science Direct, Web of Science, and Ebsco databases.</p><p><strong>Results: </strong>Of 92 studies identified, 7 met inclusion criteria, encompassing 179 implants in DS patients. Anesthesia type varied based on patient cooperation and procedure complexity: general anesthesia for uncooperative patients, local anesthesia for compliant individuals, and sedation for intermediate cases. Delayed loading (3-12 months) yielded better outcomes than immediate loading. Overdentures with locator or bar systems were effective and easier to maintain, while screw-retained fixed prostheses provided stability but required strict hygiene adherence. Clinical success rates varied, with higher success in simple cases and higher failure rates in studies involving multiple implants.</p><p><strong>Conclusions: </strong>Dental implants, combined with structured behavioral management, improve oral rehabilitation outcomes in DS patients. While sedation or general anesthesia may be required, associated risks must be carefully managed. Delayed implant loading is recommended to minimize osseointegration failures. An interdisciplinary approach, including material selection, caregiver education, and long-term maintenance, is essential for successful, individualized outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the use of proton pump inhibitors lead to an increased risk of dental implant failure? A systematic review and meta-analysis.","authors":"M Tang, Z Xie","doi":"10.4317/medoral.27043","DOIUrl":"https://doi.org/10.4317/medoral.27043","url":null,"abstract":"<p><strong>Background: </strong>Proton-pump inhibitors (PPI) are one of the commonly used medications for a variety of gastrointestinal disorders. Given the large population using PPI and the increased use of dental implants in recent times, it is pertinent to examine if PPI impacts implant outcomes. This systematic review examined the risk of implant failure amongst PPI users vs non-users.</p><p><strong>Material and methods: </strong>PubMed, Embase, Scopus, and Web of Science literature databases were scouted for cohort or case-control studies comparing implant survival between PPI users vs non-users. Last date of the literature search was 30th October 2024.</p><p><strong>Results: </strong>We identified eight studies for inclusion. Both crude and adjusted data were pooled separately. Meta-analysis of crude data demonstrated that there was a statistically significant risk of implant failure in PPI users as compared to non-users (OR: 2.71 95% CI: 1.72, 4.29 I2 = 63%). These results failed to change on sensitivity analysis. Pooled analysis of adjusted data showed that PPI use may not independently predict implant failure (OR: 1.44 95% CI: 0.92, 2.24 I2 = 73%). Exclusion of one outlier study showed a significantly increased risk of implant failure with PPI use (OR: 1.71 95% CI: 1.17, 2.50 I2 = 42%).</p><p><strong>Conclusions: </strong>There may be a tendency for higher implant failure in patients using PPI. The lack of stability of the results on sensitivity analysis and non-significant associations noted with adjusted data preclude strong conclusions. There is a need for further high-quality studies to strengthen the available evidence.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between different intermaxillary fixation systems in the surgical and orthopedic treatment of non-condylar mandibular fractures. Systematic review.","authors":"M-J Mancilla, M-A Lemus, P-T Contreras","doi":"10.4317/medoral.27264","DOIUrl":"https://doi.org/10.4317/medoral.27264","url":null,"abstract":"<p><strong>Background: </strong>The treatment of mandibular fractures can be orthopedic and/or surgical; in both modalities, intermaxillary fixation is a therapeutic tool that allows for the stabilization and reduction of fractures, guiding dental occlusion There are different methods of intermaxillary fixation, each with individual characteristics that provide therapeutic options for the practitioner. This study aims to perform a quantitative and qualitative comparison of different features of these intermaxillary fixation systems through a systematic review.</p><p><strong>Material and methods: </strong>A systematic review was performed, following the PRISMA guidelines. The Pubmed, SCOPUS, Web of Science and Cochrane databases were searched. Several variables were considered and are presented comprehensively in tables and figures. The initial literature search resulted in 51 articles, of which 9 met the inclusion criteria for the analysis.</p><p><strong>Results: </strong>Of the 51 identified articles, 28 were analyzed, with 19 excluded after full-text evaluation. Ultimately, 9 studies with 3,221 patients were included, comparing Erich arch bars (EAB), hybrid arch bars (HAB), and intermaxillary fixation screws (IMFS).</p><p><strong>Discussion: </strong>The studies focused on simple fractures with sufficient teeth for orthopedic treatment, excluding isolated maxillary fractures. Results showed differences in installation time, occlusal stability, oral hygiene, and costs, with EAB being the most expensive. Patient quality of life and complications, such as screw loss and root perforations, were also evaluated. Most studies presented a low risk of bias.</p><p><strong>Conclusions: </strong>Screw-based methods like IMFS and HAB offer shorter installation times than EAB, reducing surgery duration, costs, and biosecurity risks. While EAB remains a valid option, screw methods provide advantages in time, hygiene control, and biosecurity, with the choice depending on patient needs and surgical experience.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between periodontitis and proteinuria in chronic kidney disease: A review.","authors":"G Zhu, L Chen, Q Liu","doi":"10.4317/medoral.27304","DOIUrl":"https://doi.org/10.4317/medoral.27304","url":null,"abstract":"<p><strong>Background: </strong>Proteinuria is elevated protein in the urine possibly progressing to glomerular sclerosis, which was frequently observed in chronic kidney disease (CKD), diabetes, preeclampsia, etc. Previous studies have revealed that periodontitis and these diseases share common risk factors, so a study is necessary to discuss the potential relationship between periodontitis and proteinuria. For the moment, there are no reports that are concerned about the correlation between periodontitis and proteinuria.</p><p><strong>Material and methods: </strong>We searched PubMed for studies associated with periodontitis and proteinuria published before March 2025.</p><p><strong>Results: </strong>Existing evidence showed that periodontitis might increase the risk of proteinuria, as periodontal pathogens and periodontal inflammatory reactions were proven to injure the glomerulus and renal tubules contributing to the progression of proteinuria. On the other way, proteinuria might affect systemic inflammation and bone metabolism to increase the risk of periodontitis.</p><p><strong>Conclusions: </strong>This article reviews the relationship between periodontitis and proteinuria, reveals their predictable potential for chronic kidney injury, and makes recommendations for the treatment of periodontitis and proteinuria.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}