Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Dental management of patients with cancer across the care pathway: A scoping review of clinical protocols.","authors":"F-M Espada-Salgado, M-M Iuga, A-R Capellino-Gambetta","doi":"10.4317/medoral.27886","DOIUrl":"10.4317/medoral.27886","url":null,"abstract":"<p><strong>Background: </strong>Oral complications of cancer and its therapies impair quality of life and can disrupt oncologic care. Standardizing dental management across the care pathway is essential.</p><p><strong>Objective: </strong>To map operational protocols, guidelines, algorithms, or structured recommendations for dental management of oncology patients across pre-treatment, active treatment, and follow-up or survivorship from 2000 to 2025.</p><p><strong>Material and methods: </strong>Scoping review according to JBI guidance and reported with PRISMA-ScR. Searches were run in PubMed or MEDLINE, SciELO, Scopus, Web of Science, and the Virtual Health Library on October 19, 2025, without language restrictions. Dual screening was performed in Rayyan. Data were charted in a standardized per-record matrix and synthesized narratively, in tables, and with graphics by care phase and oncologic modality. No formal critical appraisal or meta-analysis was undertaken.</p><p><strong>Results: </strong>Twelve records were included. Coverage concentrated on pre-treatment (11 of 12; 91.7 percent), followed by follow-up or survivorship (6 of 12; 50.0 percent) and active treatment (3 of 12; 25.0 percent). Convergent recommendations included comprehensive pre-treatment assessment with sanitation, an intensified prevention bundle with hygiene instruction and topical fluorides, tooth-prognosis-based extraction criteria with defined healing windows, and supportive measures during therapy for mucositis, xerostomia, and infections. Gaps included limited standardization of survivorship pathways, insufficient personalization by oncologic modality (radiotherapy, chemotherapy, HSCT or CAR-T, immunotherapies), and scarce operational detail on safe timing windows, clinical or hematologic cutoffs, and referral or consultation triggers.</p><p><strong>Conclusions: </strong>Evidence supports an operational consensus for pre-treatment clearance and a core supportive bundle during therapy. To optimize safety and outcomes, particularly in middle-income settings, modality-specific protocols with explicit dentistry-oncology referral pathways, dose- and hematology-informed decision rules, and defined follow-up schedules are warranted.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e408-e415"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesion shrinkage and tooth preservation-based optimal timing for definitive surgery following marsupialization of cystic odontogenic jaw lesions.","authors":"J Seo, E Park, Y Cho, I Sung, J Son","doi":"10.4317/medoral.27585","DOIUrl":"10.4317/medoral.27585","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the appropriate timing for the second enucleation surgery to remove entire cystic odontogenic jaw lesions based on tooth preservation and lesion shrinkage patterns after the marsupialization of jaw lesions.</p><p><strong>Material and methods: </strong>This retrospective study included 20 patients who underwent marsupialization between January 2013 and December 2024. Changes in the number of lesions affecting the teeth before and after marsupialization were investigated, and two-dimensional lesion size changes on panoramic radiographs and three-dimensional volume changes on computed tomography images over time were measured and analyzed. Statistical analysis was performed using the Mann-Whitney test for non-normally distributed, continuous variables and the chi-square test or Fisher's exact test for nominal variables, as appropriate, with a significance level of p<0.05.</p><p><strong>Results: </strong>After an average of 62.51±31.17 weeks of marsupialization, the number of lesion-involved teeth decreased by 46.48%. An average lesion reduction of 50.85±14.95% and 62.86±17.25% (p<0.05) in two- and three-dimensional volumetric assessments was observed. Lesion shrinkage was the most significant between 16 and 24 weeks (95% confidence interval), with a mean of 18±10 weeks.</p><p><strong>Conclusions: </strong>Definitive enucleation surgery should be delayed by 24 weeks to maximize neo-bone formation in the cystic odontogenic jaw lesion cavity and maintain the vitality of the affected teeth.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e371-e377"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoexpression of programmed death receptor 1 and its ligands in oral cavity squamous cell carcinoma.","authors":"R-S Anjos, E-F Barros, A-C Firmo, C-F Nonaka, M-D Carvalho, G-P Godoy","doi":"10.4317/medoral.27926","DOIUrl":"10.4317/medoral.27926","url":null,"abstract":"<p><strong>Background: </strong>This study analyzed the immunoexpression of programmed death receptor 1 and its ligands in oral cavity squamous cell carcinoma and correlated the findings with histomorphological parameters.</p><p><strong>Material and methods: </strong>Forty cases of oral cavity squamous cell carcinoma (10 in the floor of the mouth, 10 in the palate, 10 in the lower lip, and 10 in the tongue) were selected. The percentages of cytoplasmic/membrane immunopositivity for programmed death receptor 1 and its ligands in neoplastic and stromal cells were evaluated at the tumor invasion front.</p><p><strong>Results: </strong>Programmed death-ligand 1 presented high immunoexpression in all subsites, especially at the parenchyma level. Compared to floor of the mouth and palate, lower lip and tongue exhibited higher expression of programmed death receptor 1 and programmed death-ligand 2 in parenchymal cells and of programmed death receptor 1 in stromal cells, with statistically significant differences for programmed death receptor 1 expression in lower lip (p<0.05). Tongue presented the highest median percentages of positivity for programmed death-ligand 2, with statistically significant differences when compared to floor of the mouth (neoplastic cells and stromal cells) and lower lip (stromal cells) (p<0.05). Regarding histomorphological aspects, the inflammatory infiltrate appears to be an important factor for the immunoexpression of these proteins in oral cavity squamous cell carcinoma.</p><p><strong>Conclusions: </strong>The study suggests location-dependent differences in the antitumor immune response to oral cavity squamous cell carcinoma. Inflammatory infiltrate is key to protein immunoexpression. These findings are crucial for developing new immunotherapeutic strategies for oral cancer.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e423-e430"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse events of oral analgesics after third molar extraction: A network meta-analysis of randomized controlled trials.","authors":"R-A Magesty, G-M de-Souza, I-A Fernandes, R-S de-Almeida, M-R Meireles, E-A Al-Moraissi, E-L Galvão, S-G Falci","doi":"10.4317/medoral.27956","DOIUrl":"10.4317/medoral.27956","url":null,"abstract":"<p><strong>Background: </strong>Choosing analgesics after third molar surgery requires balancing efficacy with safety. This network meta-analysis (NMA) aimed to compare and rank the safety profiles, measured by adverse events (AEs) related to medication use, of various single-dose oral analgesic regimens.</p><p><strong>Material and methods: </strong>Electronic databases were searched for randomized controlled trials (RCTs) assessing single-dose oral analgesics following third molar surgery. The primary outcome was the incidence of any AE reported before discharge. A frequentist NMA was performed to estimate relative risks (RR) and SUCRA-based probabilistic rankings. The certainty of the evidence was assessed using CINeMA.</p><p><strong>Results: </strong>Twenty-eight RCTs involving 5306 patients were included. NSAID monotherapy demonstrated a significantly higher risk of AEs compared to other non-opioid analgesics and opioid analgesics alone. Conversely, few significant differences were found between most active drugs and placebo. Probabilistic ranking indicated that both nonsteroidal anti-inflammatory drugs (NSAIDs) and placebo had a higher probability of ranking among the least safe options. Significant global inconsistency was detected across the network, and the certainty of the evidence was generally very low to low.</p><p><strong>Conclusions: </strong>The safety profile of single-dose analgesics in this model is complex. While pairwise comparisons and rankings suggested that NSAIDs might be associated with a higher frequency of adverse events, these findings are based on very low to low certainty evidence and likely reflect minor, transient events such as nausea. Additionally, the high incidence of events in the placebo group suggests that the nocebo effect plays a predominant role in event perception. Therefore, results regarding the comparative safety of NSAIDs should be interpreted with caution, balancing this potential risk against their superior analgesic efficacy.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e431-e445"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications of chlorhexidine in oral wound healing: Scoping review of current evidence and research gaps.","authors":"E Bucataru, M-D Romero-Olid, P Ramos-García, M-Á González-Moles","doi":"10.4317/medoral.27864","DOIUrl":"10.4317/medoral.27864","url":null,"abstract":"<p><strong>Background: </strong>This scoping review aimed to comprehensively synthesize the current evidence and gaps regarding the use of chlorhexidine (CHX) in oral wound healing after surgical procedures.</p><p><strong>Material and methods: </strong>PRISMA-ScR reporting guidelines were followed. A systematic search of MEDLINE, Embase, Web of Science, and Scopus was conducted to identify primary-level studies published before July-2024.</p><p><strong>Results: </strong>Sixty-six studies, encompassing 6,763 patients met eligibility criteria. Third molar extractions were the most studied procedures (n=44), where CHX use consistently improved wound healing, significantly reduced the risk of alveolar osteitis and alleviated postoperative pain, with over 70% of studies reporting favorable outcomes. CHX application, across different concentrations and pharmaceutical forms, was consistently associated with better wound healing, with gels (n=29) and rinses (n=36) showing favorable results in 75% and 80% of studies, respectively; both 0.12% (n=21, 72.7%) and 0.20% (n=41, 81.3%) concentrations proved effective, with short-term postoperative regimens (7 days, n=27) or intraoperative application (n=22) emerging as the most reliable protocols. Moreover, combinations of CHX with adjuvant agents, particularly chitosan (n=4) and hyaluronic acid (n=5), demonstrated synergistic benefits, although the number of available trials remains limited.</p><p><strong>Conclusions: </strong>In conclusion, current evidence supports the application of CHX as an effective and low-cost adjuvant in optimizing oral wound healing and preventing postoperative complications, singularly alveolar osteítis and postoperative pain after third molar extractions. Both gel and rinse formulations, as well as concentrations of 0.12% and 0.20%, have been shown to be effective, with indications related to clinical context and duration of use. Finally, CHX associatiations with chitosan and hialuronic are promising, although still based on a low evidence level. Future well-designed clinical trials are needed to address current evidence gaps, standardize administration protocols and further explore synergistic combinations.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e399-e407"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of interventional periodontal therapy on the longevity of failing dental implants: A retrospective analysis.","authors":"G-S Chatzopoulos, L-F Wolff","doi":"10.4317/medoral.28043","DOIUrl":"10.4317/medoral.28043","url":null,"abstract":"<p><strong>Background: </strong>Biological complications such as peri-implantitis present a significant challenge to the long-term stability of dental implants, often leading to failure if left untreated. While a history of periodontitis is a known risk factor, there is a lack of real-world data quantifying the \"survival extension\" provided by therapeutic interventions. This study aimed to evaluate the efficacy of surgical and non-surgical \"rescue\" therapies in extending the lifespan of dental implants that ultimately failed.</p><p><strong>Material and methods: </strong>A retrospective cohort analysis was conducted using the multi-institutional BigMouth dental data repository, examining patients treated between 2011 and 2022. The study identified 725 failed implants, which were stratified into two clusters: A \"Rescue Therapy\" group (n=130) that received active intervention (e.g., scaling, flap surgery, bone grafting) and a \"No Rescue\" control group (n=595) that received no intervention prior to failure. The primary outcome was time-to-failure, calculated in months. A subgroup analysis of implants surviving beyond 12 months was performed to isolate late-stage biological failures.</p><p><strong>Results: </strong>The Rescue Therapy group demonstrated a statistically significant survival advantage over the No Rescue group. In the subgroup of implants surviving the initial osseointegration phase (>12 months), those receiving rescue therapy achieved a median survival of 91.1 months, compared to 40.9 months for untreated implants (p<0.001). This differential equates to a median \"survival extension\" of 50.2 months (approximately 4.2 years) attributable to active intervention. Non-smokers showed a trend toward higher utilization of rescue therapies.</p><p><strong>Conclusions: </strong>Interventional periodontal therapy significantly extends the functional lifespan of failing dental implants compared to non-intervention. For late-stage failures, rescue therapy provides a clinically meaningful survival extension of over four years. These findings advocate for an aggressive interventional approach to manage peri-implant biological complications, delaying explantation and maintaining function.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e490-e496"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific evaluation of design and surface advances in Straumann implants.","authors":"P Cea-Arestín","doi":"10.4317/medoral.27841","DOIUrl":"10.4317/medoral.27841","url":null,"abstract":"<p><strong>Background: </strong>Contemporary dental implant systems are continuously evolving in terms of surface characteristics, as well as macro- and micro-design. This study evaluates the performance of recent Straumann® implants-specifically comparing Bone Level Tapered (BLT) and Bone Level Conical (BLC) designs-in relation to peri-implant bone resorption and immediate loading protocols.</p><p><strong>Material and methods: </strong>A total of 84 BLT implants and 84 BLC implants were placed in 78 patients between 2023 and 2025 across several clinics in Spain. Radiographic and periodontal probe measurements were performed to assess crestal bone level changes at one year post-placement. This retrospective cohort study focused on primary outcomes including 1-year survival rates and the evaluation of marginal bone loss (MBL).</p><p><strong>Results: </strong>The most significant result was the 98.8% success rate observed for BLC implants.</p><p><strong>Conclusions: </strong>While both Straumann® tapered implants represent excellent treatment options, BLC implants demonstrated superior improvements across all evaluated parameters. Future research should focus on identifying areas for further enhancement and comparing their performance with other leading implant systems.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e386-e389"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic inequalities and gender-specific trends in oropharyngeal cancer mortality in Spain.","authors":"L Cayuela, J Librero, P Infante-Cossio, J Pereyra-Rodriguez, A Cayuela","doi":"10.4317/medoral.27957","DOIUrl":"10.4317/medoral.27957","url":null,"abstract":"<p><strong>Background: </strong>Consistent geographical disparities in oropharyngeal cancer (OPC) mortality rates have been observed across Europe, with distinct trends emerging among men and women. This study provides a detailed subnational analysis of OPC mortality in Spain between 1999 and 2023, categorised by gender and administrative region.</p><p><strong>Material and methods: </strong>We conducted an ecological analysis using ICD-10 C10 mortality data for all 50 Spanish provinces and the two autonomous cities (Ceuta and Melilla). Hierarchical Bayesian spatio-temporal Poisson models, fitted via INLA, were employed to decompose variance and identify gender-specific risk patterns.</p><p><strong>Results: </strong>Gender-specific patterns were markedly distinct. Male mortality showed a strong spatial structure (88.1% of variance), with persistent high-risk clusters in Northern Spain (Asturias, A Coruña, Cantabria) and the Canary Islands. Despite a modest national decline, risk often remained stable or increased in these high-risk areas; for instance, Cantabria's relative risk (RR) peaked at 2.62 in 2023. This pattern is consistent with entrenched traditional risk factors (tobacco and alcohol use). Conversely, female mortality was dominated by a strong national temporal increase (17.2% of variance), likely reflecting a growing HPV-associated burden. Risk escalated nearly uniformly across the country, rising from RR 0.62 in 1999 to 1.54 in 2023. Localised temporal deviations were significant for men (10.2% interaction), but negligible for women (0.4%), confirming a synchronised, nationwide female trend.</p><p><strong>Conclusions: </strong>OPC mortality dynamics demand dual intervention strategies. Deep-rooted gender disparities in the northern and island provinces suggest strengthening tobacco and alcohol control campaigns. The rapid and widespread increase in female mortality highlights the need of expanding HPV vaccination programmes nationwide.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e446-e456"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146041625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines and consensus statements integrating periodontal disease into cardiology, diabetes care and dementia: A scoping review and gap analysis.","authors":"F-M Espada-Salgado, S-V Stefanescu, M-M Iuga","doi":"10.4317/medoral.27981","DOIUrl":"10.4317/medoral.27981","url":null,"abstract":"<p><strong>Background: </strong>Periodontal disease (PD) is a prevalent chronic inflammatory condition linked to cardiovascular disease, diabetes mellitus and dementia, yet it is unclear how far medical specialty guidelines translate this evidence into concrete recommendations for assessment, referral and shared care.</p><p><strong>Objective: </strong>To map clinical practice guidelines, consensus statements and position papers that contain explicit, actionable recommendations on PD within major medical specialties.</p><p><strong>Material and methods: </strong>A scoping review was conducted following Joanna Briggs Institute guidance and reported according to PRISMA-ScR. PubMed/MEDLINE, Scopus, Web of Science Core Collection and LILACS were searched from 2005 to 2025 using MeSH/DeCS and free-text terms for periodontal disease, guideline documents and target specialties. Records were de-duplicated, screened in Rayyan by two independent reviewers and included if they were peer-reviewed or professionally endorsed guidance for adults that contained explicit periodontal recommendations. Data were charted in a standardized matrix and synthesized descriptively by specialty.</p><p><strong>Results: </strong>The search yielded a small corpus of eligible documents. Operational recommendations were concentrated in diabetes-periodontitis statements, with fewer detailed pathways in cardiovascular and dementia care and very limited or absent guidance in obstetrics/gynecology and rheumatology. Across documents, PD was framed as a modifiable risk or complication, but periodontal definitions, screening intervals and division of responsibilities between medical and dental providers were heterogeneous or poorly specified.</p><p><strong>Conclusions: </strong>Few medical specialty guidelines formally integrate PD into chronic disease care. Harmonized, multidisciplinary guidance with standardized definitions, clear referral criteria and shared follow-up schedules is needed to embed periodontal health within noncommunicable disease management.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e457-e464"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclooxygenase-2 selective inhibitors increase the risk of alveolar osteitis: A systematic review and meta-analysis.","authors":"M-A Isiordia-Espinoza, A Hernández-Gómez, R Bologna-Molina, N Serafín-Higuera, N Molina-Frechero, E Gómez-Sánchez, S López-Verdín, J-M Guzmán-Flores","doi":"10.4317/medoral.27577","DOIUrl":"10.4317/medoral.27577","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this systematic review was to determine the risk of alveolar osteitis with the use of traditional non-steroidal anti-inflammatory analgesics (NSAIDs) and COX-2 selective inhibitors compared to placebo using data from published clinical trials.</p><p><strong>Material and methods: </strong>Embase and Medline/PubMed databases were employed to search for clinical trials. Articles that met the inclusion criteria were assessed for risk of bias using the Cochrane tool and data on alveolar osteitis were specifically extracted. Statistical analysis was performed using Review Manager 5.3 software.</p><p><strong>Results: </strong>The risk assessment for alveolar osteitis concerning traditional NSAIDs included 19 clinical trials (n=2888) while for COX-2 inhibitors included 13 clinical trials (n=3820). Overall statistical analysis and subgroup evaluation by medication indicated that traditional NSAIDs did not increase the risk of alveolar osteitis. On the other hand, subgroup statistical analysis for selective COX-2 inhibitors suggested that rofecoxib elevated a patient's risk of developing alveolar osteitis (n=947, I2=0%, Z=2.52, OR=1.89, 95% CI=1.15 to 3.10, p=0.01) compared with placebo. Sensitivity analysis of the rofecoxib data exhibited high statistical robustness.</p><p><strong>Conclusions: </strong>Data indicates that rofecoxib increases the risk of alveolar osteitis in patients undergoing tooth extraction.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e363-e370"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}