Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Emerging trends in pharmacological treatment of inferior alveolar nerve sensory disorders: a scoping review.","authors":"B-D Mesquita, A-C Gomes, B-C Vasconcelos, C-A Lago, M-R Arruda, E-S Andrade","doi":"10.4317/medoral.26519","DOIUrl":"10.4317/medoral.26519","url":null,"abstract":"<p><strong>Background: </strong>Sensory disorders of the inferior alveolar nerve, often arising from dental procedures, markedly impact the quality of life of patients. This article proposes a scoping review to analyze emerging trends in pharmacological treatment for these disorders, addressing scientific gaps and clinical practices.</p><p><strong>Material and methods: </strong>The review followed the PRISMA-ScR protocol, conducting data searches across various databases, including PubMed and Cochrane, until March 2024. Case studies and series related to patients with sensory disorders of the inferior alveolar nerve undergoing pharmacological treatment were included.Parte inferior do formulário Results: Out of the initial 542 records, 7 studies were included after rigorous selection, displaying low bias risk. Medicinal therapies varied, encompassing analgesics, corticosteroids, anesthetics, and vitamin complexes. Dipyrone stood out in the preoperative phase, while prednisone proved effective in paresthesias. Selegiline, an MAO-B inhibitor, introduced an innovative approach.</p><p><strong>Conclusions: </strong>Agents such as selegiline offer an innovative approach to sensory restoration, while corticosteroids exhibit variable efficacy. Dipyrone is effective in preoperative pain control, and vitamin complexes provide regenerative and neuroprotective benefits. However, it is essential to consider that treatment success may vary and to address the individual needs of patients.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e170-e178"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of Dexmedetomidine as an additive to local anesthetics in dental procedures: A systematic review.","authors":"D-A Diniz, A-J França, J-R Laureano-Filho, E-P Pellizzer, S-L Moraes, B-C Vasconcelos","doi":"10.4317/medoral.26439","DOIUrl":"10.4317/medoral.26439","url":null,"abstract":"<p><strong>Background: </strong>This review aimed to assess if the use of dexmedetomidine as an additive to local anesthetics promotes greater safety and efficacy than local anesthetics alone in dental procedures.</p><p><strong>Material and methods: </strong>the systematic review was structured according to the PICO strategy and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist. Studies were included based on the eligibility criteria, and data from the included studies were collected by one author. An additional author reviewed the compilation. Altogether, nine studies were included: eight randomized clinical trials and one controlled clinical trial. Of these, six were related to tooth extraction. Most studies reported the use of lidocaine as the local anesthetic. Levobupivacaine was used in one study.</p><p><strong>Results: </strong>In total, 352 patients were evaluated. Despite the heterogeneity between studies, it can be suggested that when used as an additive to local anesthetics, dexmedetomidine has the potential to decrease postoperative pain and latency period and prolong anesthetic duration.</p><p><strong>Conclusion: </strong>There are scant reviews that summarizes the effectiveness of dexmedetomidine as an adjuvant to local anesthetics. These studies can positively impact the lives of the concerned population.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e160-e169"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular endothelial growth factor immunoexpression in oral paracoccidioidomycosis.","authors":"E-S Dias, L-C Freitas, M Miyazawa, D-A Nogueira, C-E Oliveira, A-A Pereira, J-A Hanemann","doi":"10.4317/medoral.26886","DOIUrl":"10.4317/medoral.26886","url":null,"abstract":"<p><strong>Background: </strong>Paracoccidioidomycosis (PCM) is a systemic mycosis endemic and limited to Latin America. Brazil is responsible for more than 80% of diagnosed cases in the world. Since PCM is not a notifiable disease, there are still no accurate data on its incidence in Brazil. Vascular endothelial growth factor (VEGF) is considered the main vascular endothelial growth factor expressed in the process of angiogenesis, both under physiological and pathological conditions. To date, there are not studies in the literature that evaluated the expression of VEGF in oral PCM lesions. Therefore, the objective of this study was to evaluate the prevalence of oral lesions of PCM diagnosed from 1998 to 2020; to analyze the immunoexpression of VEGF in oral lesions of PCM; and to compare the VEGF immunostaining with the clinical and microscopic aspects of these lesions.</p><p><strong>Material and methods: </strong>Clinical data of 98 cases of patients with oral PCM were evaluated. A total of 41 selected cases were quantitatively and qualitatively analysed by immunohistochemistry for VEGF.</p><p><strong>Results: </strong>Our results showed that oral PCM preferentially affects white males, with mean age of 50.2 years, and the gingiva and the alveolar ridge. It was not possible to correlate VEGF immunoexpression with clinical and microscopic variables.</p><p><strong>Conclusions: </strong>Oral PCM is a relatively uncommon pathological condition and that, in our sample, the immunoexpression of VEGF was mild and observed in a reduced number of cases.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e240-e246"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating quality of life in third molar surgery: a scoping review of the postoperative symptom severity (PoSSe) scale.","authors":"E-F Maferano, E-L Filho, P-G Silva, A-F Granville-Garcia, R-T Firmino, M-D Perazzo, P-R Martins-Filho, F-W Costa","doi":"10.4317/medoral.26839","DOIUrl":"10.4317/medoral.26839","url":null,"abstract":"<p><strong>Background: </strong>This scoping review evaluated the key dimensions of quality of life impacted by third molar surgery as assessed by the Postoperative Symptom Severity (PoSSe) scale, and their variations across diverse populations and clinical contexts.</p><p><strong>Material and methods: </strong>A comprehensive literature search was performed across multiple databases including MEDLINE, EMBASE, CINAHL, PsycINFO, The Cochrane Library, Livivo, LILACS, Web of Science, Scopus, Epistemonikos, and Google Scholar on April 30, 2024, with an update on July 31, 2024. We included analytical observational studies and randomized clinical trials that utilized the PoSSe scale to assess quality of life. There were no restrictions based on language, location, or publication period. Data from eligible studies were extracted and analyzed descriptively.</p><p><strong>Results: </strong>The search identified 3,438 records, with 31 studies ultimately included. These studies employed the PoSSe scale in various methodological designs to primarily assess quality of life following lower third molar removal. The dimensions most affected were feeding, appearance, and pain, which showed significant correlations with edema, trismus, and analgesic use. Additional influencing factors included gender, tobacco use, surgeon skill level, Pell and Gregory classification, and preemptive analgesia.</p><p><strong>Conclusions: </strong>This review has demonstrated the PoSSe scale's effectiveness in evaluating the multifaceted impacts of third molar surgery on patient quality of life, sensitive to differences in surgical techniques, surgeon experience, and patient-specific factors. Future research should explore longitudinal assessments with the PoSSe scale to optimize surgical practices and improve long-term patient outcomes.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e232-e239"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of ChatGPT 3.5, 4.0, 4o and Gemini in diagnosing oral potentially malignant lesions based on clinical case reports and image recognition.","authors":"P Pradhan","doi":"10.4317/medoral.26824","DOIUrl":"10.4317/medoral.26824","url":null,"abstract":"<p><strong>Background: </strong>The accurate and timely diagnosis of oral potentially malignant lesions (OPMLs) is crucial for effective management and prevention of oral cancer. Recent advancements in artificial intelligence technologies indicates its potential to assist in clinical decision-making. Hence, this study was carried out with the aim to evaluate and compare the diagnostic accuracy of ChatGPT 3.5, 4.0, 4o and Gemini in identifying OPMLs.</p><p><strong>Material and methods: </strong>The analysis was carried out using 42 case reports from PubMed, Scopus and Google Scholar and images from two datasets, corresponding to different OPMLs. The reports were inputted separately for text description-based diagnosis in GPT 3.5, 4.0, 4o and Gemini, and for image recognition-based diagnosis in GPT 4o and Gemini. Two subject-matter experts independently reviewed the reports and offered their evaluations.</p><p><strong>Results: </strong>For text-based diagnosis, among LLMs, GPT 4o got the maximum number of correct responses (27/42), followed by GPT 4.0 (20/42), GPT 3.5 (18/42) and Gemini (15/42). In identifying OPMLs based on image, GPT 4o demonstrated better performance than Gemini. There was fair to moderate agreement found between Large Language Models (LLMs) and subject experts. None of the LLMs matched the accuracy of the subject experts in identifying the correct number of lesions.</p><p><strong>Conclusions: </strong>The results point towards cautious optimism with respect to commonly used LLMs in diagnosing OPMLs. While their potential in diagnostic applications is undeniable, their integration should be approached judiciously.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e224-e231"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the association between coronary artery blockage and periodontal health status in patients undergoing coronary angiography: a cross-sectional study.","authors":"A Khandelwal, R-V Anegundi, P-K Yadalam, S-B Shenoy, K Subramanyam, C-M Ardila","doi":"10.4317/medoral.26946","DOIUrl":"10.4317/medoral.26946","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence suggests a potential link between periodontal disease and the development of atherosclerosis, positioning periodontal disease as a possible risk factor for cardiovascular diseases (CVD). This study aimed to evaluate periodontal status in patients with coronary artery disease (CAD) by measuring the Periodontal Inflamed Surface Area (PISA) score in individuals undergoing coronary angiography.</p><p><strong>Material and methods: </strong>In this cross-sectional study, 300 patients scheduled for coronary angiography at K.S. Hegde Medical Hospital, Mangalore, India, were recruited. Comprehensive medical and dental histories were obtained prior to the procedure. The PISA score was calculated using standardized periodontal measurements. Patients were categorized into three groups based on angiographic findings: no coronary artery blockage, blockage in one or more vessels with <50% stenosis, and blockage in one or more vessels with ≥50% stenosis. Additional subgroup analyses were conducted for single-, double-, and triple-vessel disease. A p-value of <0.05 was considered statistically significant.</p><p><strong>Results: </strong>A significant increase in PISA scores was observed in patients with ≥50% coronary artery stenosis compared to those with <50% stenosis and no stenosis. However, the extent of vessel obstruction appeared independent of the degree of periodontal destruction.</p><p><strong>Conclusions: </strong>This study suggests that periodontal disease may act as a pro-atherogenic factor in the context of CAD, potentially contributing to the progression of atherosclerosis rather than being a direct causative agent. These findings underscore the importance of considering oral health in cardiovascular risk assessment and management for patients with coronary artery disease.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e306-e312"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching oral and maxillofacial pathology and oral medicine in undergraduate and postgraduate in Latin America.","authors":"S Trezena-Costa, D-R Martelli, P-V Cardoso, G Gilligan, J-L Flores, W-A Arriagada, C-P Veja, P-R Ortiz, W-D Azañero, R-B Molina, M-V Dorrego, R-M Pedraza, F-R Pires, B-A Andrade, H Martelli-Júnior","doi":"10.4317/medoral.26773","DOIUrl":"10.4317/medoral.26773","url":null,"abstract":"<p><strong>Background: </strong>Oral and Maxillofacial Pathology (OP) and Oral Medicine (OM) are specialties in dentistry responsible for diagnosis and management of diseases affecting the oral and maxillofacial regions, and to best of our knowledge no information about teaching of OP and OM in undergraduate and postgraduate courses in Latin America have been described. The aim of the present study was to evaluate dimensions related to the teaching of OP and OM in South America and Mexico.</p><p><strong>Material and methods: </strong>A structured questionnaire was elaborated and sent to 10 countries, with a professional in each country responsible for answering it. The questions were related to theoretical, laboratory, clinical activities, specialization, residency, master's and PhD courses, and to information from the legislation of OP and OM in each country.</p><p><strong>Results: </strong>70% of the countries studied, the disciplines of OP and OM are compulsory with workload ranged from 60 to 660 hours. Seven countries have mandatory discipline of OP and 40% have laboratory activities with the study of histopathology. In the case of OM, 60% of the countries have theoretical classes and 40% have mandatory clinical practices. In all ten countries there are laws regulating the opening and operation of undergraduate courses in dentistry. Regarding to the teaching of the postgraduate, the most common was specialization, offered by seven countries, master's degree programs in six countries, while residency is offered by only two countries and the specific PhD in OP/OM offered only in Brazil. Only three countries do not offer postgraduate scholarships and two do not have a research funding agency.</p><p><strong>Conclusions: </strong>OP and OM are specialties offered at both undergraduate and postgraduate in Latin American countries, with small differences between teaching methodologies in undergraduate and type of training in postgraduate.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e192-e198"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive treatment of benign oral vascular lesions: A retrospective study.","authors":"H-C Silva, A-C Teles, G-F Rocha, E-M Silveira, D-W Douglas-de-Oliveira, A-T Mesquita","doi":"10.4317/medoral.26809","DOIUrl":"10.4317/medoral.26809","url":null,"abstract":"<p><strong>Background: </strong>The ethanolamine oleate (EO) in different concentrations has been used in sclerotherapy of oral benign vascular lesions (OBVLs). The aim of the present study was to define demographic and clinical characteristics of patients with OBVLs treated with 5% EO.</p><p><strong>Material and methods: </strong>A retrospective study was conducted of cases treated by sclerotherapy from 1992 to 2022, and medical records of 52 patients with OBVLs were analysed. Thus, 44 cases with complete data were selected and described. Categorical data were analyzed using the chi-square test, with the significance level set at 5% (p < 0.05).</p><p><strong>Results: </strong>Mean age was 52.89 years (range seven to 82 years). The female sex was predominant (77%) and brown was the most common skin color (54%). Most lesions occurred on the lower lip (65.9%), tongue (11.4%), buccal mucosa (9.1%), upper lip (6.8%) and palate (25%.3%). Approximately 73% of the lesions were ≤ 1 cm, > 1 ≤ 2 cm (18.2%,) and > 2 cm (9.1%). Complete regression of the lesions occurred in 97.7% of the cases, with no case of recurrence and no need for complementary surgery. All patients were satisfied with the treatment.</p><p><strong>Conclusions: </strong>Sclerotherapy with 5% EO is a safe and effective method for the treatment of OBVLs.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e217-e223"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does oral hygiene prevents nosocomial infections in hospitalized patients? A systematic review and meta-analysis.","authors":"K-M Miyahira, M-L Martins, W-F Liberato, M-B Magno, D-D Ferreira, J-R Tenório, L-C Maia, G-F Castro","doi":"10.4317/medoral.26706","DOIUrl":"10.4317/medoral.26706","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the impact of oral hygiene (OH) with chlorhexidine (CHX) on the evolution of nosocomial infections (NI).</p><p><strong>Material and methods: </strong>Electronic searches were carried out in PubMed, Scopus, Cochrane Library, Web of Science, VHL, and Grey Literature databases. Randomized clinical trials were included. Methodological quality and risk of bias were assessed using RoB 2.0. Meta-analyses were carried out comparing patients who did or did not receive OH with CHX (0.05%, 0.12% and 2%) for NI, Ventilator-Associated Pneumonia (VAP), S. aureus infection (SA), duration of mechanical ventilation (MV), length of hospital stay and Intensive Care Unit (ICU). The certainty of evidence (CE) was evaluated with GRADE approach.</p><p><strong>Results: </strong>Thirteen studies were selected for quantitative and qualitative synthesis. The risk for VAP (RR 0.72 [0.58, 0.90], p=0.003) and NI (RR 0.70 [0.58, 0.83], p<0.001) were lower in patients of the CHX groups compared to controls, independently for [CHX] used for NI (RR≥0.49, p≤0.03). Patients who received CHX 2×/day presented similar risk to control (RR 0.98 [0.75, 1.30], p=0.91); while 3 and 4×/day or more (RR≥0.52, p≤0.002) presented lower risk for NI. Similar risk for SA was observed among groups (RR 0.42 [0.14, 1.26], p=0.12). The average days of hospitalization (p=0.67), ICU stay (p=0.37) and MV (p=0.57) did not differ between the groups. CE ranged from very low to moderate.</p><p><strong>Conclusions: </strong>OH with CHX reduced NI, regardless of concentration, when used 3×/day or more. However, it had no effect against AS and did not reduce length of hospital stay.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e179-e191"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent biofilm detection with ensemble of deep learning networks.","authors":"B-P Sobrinho, B-P Silva, K-M Andrade, B-P Sobrinho, D-A Ribeiro, J-N Santos, L-R Oliveira, P-R Cury","doi":"10.4317/medoral.26937","DOIUrl":"10.4317/medoral.26937","url":null,"abstract":"<p><strong>Background: </strong>Dental biofilm is traditionally identified visually, which can be challenging and time-consuming due to its color similarity with the tooth. The aim of this study was to evaluate the performance of U-Net neural networks for the automatic detection of dental biofilm without disclosing agents on intraoral photographs of deciduous and permanent teeth using an ensemble strategy.</p><p><strong>Material and methods: </strong>This retrospective exploratory study was conducted on two datasets of intraoral images obtained from deciduous and permanent dentitions. The first dataset was used to validate dental biofilm annotations by an expert with disclosing agents. The second dataset, without disclosing agents, was employed to train and evaluate the U-Net neural network in the identification of dental biofilms using an ensemble strategy.</p><p><strong>Results: </strong>The performance of the ensemble method was assessed using a cross-validation procedure, with six groups dedicated to training, one group for validation, and one group exclusively taken as a test set for the final evaluation of the ensemble. The performance of the neural network was evaluated using accuracy, F1 score, sensitivity, and specificity. The U-Net neural network achieved an accuracy of 93.1%, sensitivity of 65.1%, specificity of 95.9%, and an F1 score of 63.0%.</p><p><strong>Conclusions: </strong>The U-Net neural network using the ensemble strategy was able to automatically identify visually detectable dental biofilms on intraoral photographs. The application of this new knowledge will soon be available in clinical practice.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e282-e287"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}