Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects.","authors":"J-A Gil-Montoya, M-J Gerez-Muñoz, E-M Triviño-Ibáñez, E Rosel, M Bravo, J-C Rómero-Fábrega, S Morales-Santana, M Gómez-Río","doi":"10.4317/medoral.27612","DOIUrl":"10.4317/medoral.27612","url":null,"abstract":"<p><strong>Background: </strong>Lactoferrin in saliva has been proposed as a possible diagnostic biomarker for Alzheimer's disease, as it is associated with ß-amyloid load in the brain. The aim of this study was to find out whether there is an association between salivary lactoferrin and cerebral ß-amyloid load and the involvement of periodontal disease in this possible connection.</p><p><strong>Material and methods: </strong>Six exploratory comparison groups were designed: participants with mild cognitive impairment (n=50) (positive PET-amyloid with and without periodontal disease and negative PET-amyloid with and without periodontal disease) and cognitively normal older individuals with and without periodontal disease (n=19). All participants were recruited from referral hospitals in Granada, Spain, and from a nursing home in the same socio-economic area as the hospital participants. A salivary lactoferrin determination and a periodontal assessment has been performed in each of the participants.</p><p><strong>Results: </strong>The results show that both having an atypical ß-amyloid load in the brain (PET+) and having periodontal disease are clearly associated with a lower concentration of salivary lactoferrin (p=0.011 and p=0.032), but not with age or gender.</p><p><strong>Conclusions: </strong>In this studio, the positive PET-amyloid and periodontal disease are related independently with lower lactoferrin levels.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e118-e123"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12742882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of localized juvenile spongiotic gingival hyperplasia following surgical excision: A systematic review and meta-analysis.","authors":"A-I Lorenzo-Pouso, A Pérez-Jardón, A González-González, I Ibáñez-Lafuente-de-Mendoza, V-C Caponio, L-A Chauca-Bajaña, K-A Segura-Cueva, M Pérez-Sayáns","doi":"10.4317/medoral.27622","DOIUrl":"10.4317/medoral.27622","url":null,"abstract":"<p><strong>Background: </strong>Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a rare, benign gingival lesion with distinctive clinicopathological features. Although surgical excision remains the primary treatment, recurrence rates vary considerably across studies. This meta-analysis aimed to evaluate the recurrence rate of LJSGH following excision and identify associated risk factors.</p><p><strong>Material and methods: </strong>A systematic review was conducted using MEDLINE, SCOPUS, and WHO LILACS database for articles published until April 2025. Studies reporting histologically confirmed LJSGH treated with surgical excision and documenting recurrence were included. Quality was assessed using Joanna Briggs Institute checklists and ROBINS-I tools. Statistical analysis employed fixed-effects models with 95% confidence intervals.</p><p><strong>Results: </strong>Thirteen studies encompassing 119 patients met the inclusion criteria. The pooled recurrence rate was 7% (95% CI: 0.01-30.00%), with individual rates ranging from 0% to 66.7%. Most recurrences occurred within 2-8 months postoperatively (68.4%), though some were reported up to 5 years. Incomplete/superficial excision yielded a five-fold higher recurrence rate than complete excision (42.1% vs. 8.3%). Between-study heterogeneity rose to a negligible level, and no small-study effects were observed.</p><p><strong>Conclusions: </strong>LJSGH presents a low recurrence risk post-excision. Complete excision with adequate margins is key to prevention. Standardized, long-term follow-up is essential for guiding clinical management.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e124-e131"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12742886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronectomy as an alternative technique to complete extraction of mandibular third molars with risk of nerve injury.","authors":"L Rico-Barroso, M Barroso-Medel, J Gutiérrez-Pérez, M Serrera-Figallo, D Torres-Lagares","doi":"10.4317/medoral.27459","DOIUrl":"10.4317/medoral.27459","url":null,"abstract":"<p><strong>Background: </strong>Extraction of mandibular third molars (MTM) is one of the most frequent surgical procedures in Oral Surgery. This intervention is not without risks, as one of the most common is an injury of the inferior alveolar nerve (IAN). The main objective of this systematic review is to compare the coronectomy technique with conventional extraction of MTM with a high risk of injury to the IAN, thus determining whether coronectomy is an effective surgical alternative in preventing nerve injuries.</p><p><strong>Material and methods: </strong>A bibliographical search was conducted in October 2024 in the Pub-Med and Cochrane-Database databases, and 211 studies were obtained. Finally, 16 studies were included in the systematic review, with a total sample of 2551 patients. 2280 coronectomy procedures and 841 extractions were performed.</p><p><strong>Results: </strong>6.22% of the coronectomies performed were unsuccessful. The incidence of IAN injury was 6.53% in the extraction group, while in the coronectomy group, it was only 0.56%. Permanent IAN injury was 1.18% and 0.13%, respectively. The most common complication in both groups was postoperative pain, with similar results, 15.69% in the extraction group vs. 14.21% in the coronectomy group. Lingual nerve injury was infrequent and transient in both groups, affecting 0.12% of extractions and 0.26% of coronectomies. The complication with the highest incidence in the coronectomy group was root migration, mainly during the first 6 months.</p><p><strong>Conclusions: </strong>Coronectomy is a safe and effective alternative technique for the management of MTM with a high risk of IAN injury.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e19-e30"},"PeriodicalIF":2.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12743382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in oral squamous cell carcinoma: a systematic review.","authors":"M López-Galindo, M-D Sousa-Roques","doi":"10.4317/medoral.27565","DOIUrl":"10.4317/medoral.27565","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is one of the most aggressive cancers in the oral cavity, often diagnosed at advanced stages, leading to significantly reduced survival rates. Traditional diagnostic methods, such as clinical examination and histopathology, have limitations in detecting early stages and assessing tumor variability. Molecular biomarkers, however, have shown great potential in overcoming these limitations by improving early diagnosis, prognosis, and personalized treatment. These biomarkers, when integrated with the TNM staging system, may provide more accurate and personalized clinical management.</p><p><strong>Material and methods: </strong>A systematic review was conducted by searching PubMed, Scopus, and Web of Science databases for studies on biomarkers in OSCC published between January 2018 and December 2024. The studies were selected based on strict inclusion and exclusion criteria, focusing on those that investigated biomarkers related to OSCC diagnosis, prognosis, and therapeutic implications.</p><p><strong>Results: </strong>This review includes 10 studies involving 1024 patients with OSCC. Key biomarkers such as Ki67, HSP60, Survivin, E-cadherin, and PD-L1 were significantly associated with tumor progression, lymph node metastasis, and poor prognosis. The combined use of these biomarkers with traditional histopathological methods could enhance diagnostic accuracy, allowing for better patient stratification and more targeted treatment approaches. Additionally, saliva-based biomarkers have emerged as a promising, non-invasive diagnostic tool with high sensitivity and specificity for early detection of OSCC.</p><p><strong>Conclusions: </strong>The identification of specific biomarkers can significantly enrich the diagnostic, prognostic, and therapeutic management of OSCC, complementing the TNM staging system. These biomarkers are linked to critical clinical variables such as metastasis, survival, and response to treatment. Saliva-based biomarkers hold promise due to their non-invasive nature, but further validation through multicenter studies and standardization is required for their widespread clinical adoption.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e82-e88"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12742883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological analysis of oral and perioral keratoacanthoma: a systematic review based on case reports and case series.","authors":"C-L Menna-Barreto, L-B Kirschnick, L-F Schuch, F-M Girardi, M-A Lopes, M-D Martins","doi":"10.4317/medoral.27631","DOIUrl":"10.4317/medoral.27631","url":null,"abstract":"<p><strong>Background: </strong>To systematically review the literature on clinicopathological features of keratoacanthomas (KA) in the oral and perioral region.</p><p><strong>Material and methods: </strong>The review protocol as registered under the number CRD42022323274. Electronic searches were conducted in four databases with a specific search strategy using MeSH and free terms.</p><p><strong>Results: </strong>60 studies reporting 73 cases of KA were included in this systematic review. KA affects more men with a mean age of 49.09 years old. Sun-exposed area of the lower lip was the most common anatomical location of the perioral lesions (38.35%) and the oral mucosa (9.58%) of the intra-oral ones. The most frequent clinical presentation of the perioral lesions was of an ulcerated nodule (36.23) and intra-orally of an papule (11.59) or nodule (11.59). Incisional biopsies were the commonest procedure for the diagnosis. The histological findings commonly presented a hyperplastic epithelial tissue forming a crater-like structure filled with keratin. Slightly atypia, keratin pearls and an inflammatory infiltrate in connective tissue could also be seen. Surgical excision was the treatment of choice in the majority of cases (45.71%). A low recurrence rate (6.89%) was seen in a mean follow-up time of 20.54 months.</p><p><strong>Conclusions: </strong>KA affects commonly sun-exposed areas of men in their sixth decade of life. Given the similarity of squamous cell carcinoma, it is important to study KA to help clinicians with the correct diagnosis and treatment.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e138-e145"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12742887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological features of double and inverted mesiodens: a systematic review of the literature and presentation of two cases.","authors":"A Lo-Casto, V Panzarella, E Palizzolo, R Mauceri, G Giuliana, F Bencivinni, G La-Mantia, G Campisi, M De-Angelis, G La-Tona, O Di-Fede","doi":"10.4317/medoral.27513","DOIUrl":"10.4317/medoral.27513","url":null,"abstract":"<p><strong>Background: </strong>Mesiodens are the most prevalent supernumerary teeth, defined as a dentition anomaly. Mesiodens account for 80% of all supernumerary teeth, with a prevalence in the general population of 0.15% -1.9%. Mesiodens show a higher frequency in man than in women, it is usually found in the front upper jaw, between the midlines of maxillary central teeth. It may be normally oriented or have inverted and transverse orientation. Single or multiple mesiodens may occur; however, double mesiodens is rarer (10-19% of all patients with mesiodens), and even rarer is its double inversion, with the crown and root oriented towards the nasal and oral cavities. The aim of this study is to investigate the main cone-beam computed tomography (CBCT) radiological features of patients affected by mesiodens. Two cases of double mesiodens, one of which with double inversion, in pediatric patients are reported.</p><p><strong>Material and methods: </strong>According to PRISMA guidelines, a systematic review search was conducted on PubMed, Scopus, and Web of Science. Observational studies conducted on patients with double mesiodens were selected and analyzed, including both radiological features and clinical characteristics. Furthermore, two cases of patients with double mesiodens were reported.</p><p><strong>Results: </strong>Fourteen studies were included, and 14 patients affected by double mesiodens were analyzed (12 males, 2 females, with a mean age of 13.5 ± 6.4 years).</p><p><strong>Conclusions: </strong>The present study underscores the importance of considering the CBCT a fundamental investigation to define and appropriate diagnosis and management, and to avoid complications related to a late diagnosis and/or an unnecessary surgical approach.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e906-e915"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of actin cytoskeleton organization genes in oral cancer and oral potentially malignant disorders using oral tissue RNA-seq database.","authors":"M Serna-García, A Formaggio, M-C Carceller, J-J Romero, N Flacco","doi":"10.4317/medoral.27364","DOIUrl":"10.4317/medoral.27364","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer and oral potentially malignant disorders (leukoplakia and oral submucous fibrosis) are prevalent and clinically significant oral diseases. Actin, crucial for epithelial tissue integrity, undergoes cytoskeleton reorganization associated with increased invasiveness in oral cancer.</p><p><strong>Material and methods: </strong>Bioinformatic analysis of RNA-seq data from GEO public databases was performed to detect differentially expressed genes in oral cancer, leukoplakia and oral submucous fibrosis. Enrichment analysis of the differentially expressed genes was performed using DAVID and GSEA software. ROC curve and survival analysis were conducted to assess the discriminative capacity of these genes as possible biomarkers. The results were further validated using RNAseq data from The Cancer Genome Atlas (TCGA).</p><p><strong>Results: </strong>EPRS1 was consistently overexpressed in all three pathologies. Key genes (ACTIN1, LIMK1, CORO1C, INF2, SH3D21, CFL1, FSCN1, MYO1B) implicated in actin cytoskeleton organization were identified, suggesting their role in oral potentially malignant disorders and cancer progression. Receiver operating characteristic (ROC) curves on 522 TCGA samples demonstrated these genes' potential as early biomarkers for oral cancer, with their inhibition associated with improved survival.</p><p><strong>Conclusions: </strong>The identified genes offer insights into actin-related mechanisms and potential pathways for the diagnosis and treatment of oral cancer. Nonetheless, further research is essential to validate these results.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e857-e865"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological evolution of gingival cancer in Spain from 2001 to 2022: a longitudinal study.","authors":"J Celis-Dooner, M-C Mateo-Sidrón-Antón, R Cerero-Lapiedra, L-A Moreno-López","doi":"10.4317/medoral.27465","DOIUrl":"10.4317/medoral.27465","url":null,"abstract":"<p><strong>Background: </strong>Over the past decades, the literature has described epidemiological changes in oral cancer. However, few updated studies specifically address this issue, particularly those examining it separately from pharyngeal cancer. Some authors suggest gingival cancer is the only intraoral cancer with a higher prevalence among women.</p><p><strong>Material and methods: </strong>A retrospective longitudinal study was conducted using the Specialized Care Activity Registry from the Minimum Basic Data Set to obtain data on gingival cancer patients in Spain from 2001 to 2022.</p><p><strong>Results: </strong>Data from 5,749 patients showed 51.8% were men and 48.2% women. A final predominance in women was observed. The average recorded age was 68.3 years, increasing in both sexes over time. A low frequency of tobacco and alcohol consumption was noted. The age-adjusted incidence was 0.61, with a convergence between sexes due to increased female incidence.</p><p><strong>Conclusions: </strong>During the study period, a reversal in the male-to-female ratio was observed, along with an increase in recorded age, a preference for the mandible over the maxilla, low tobacco and alcohol consumption, and incidence convergence between sexes due to rising female cases.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e892-e897"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dexmedetomidine on perioperative events of orthognathic surgery: a systematic review of randomized controlled trials.","authors":"C-M Mesquita, A-C Diniz, S-P Sakamoto, W-A Vieira, R-B Brito-Junior, M-D Costa, L-R Paranhos","doi":"10.4317/medoral.27260","DOIUrl":"10.4317/medoral.27260","url":null,"abstract":"<p><strong>Background: </strong>Orthognathic surgery is a complex invasive procedure associated with common postoperative symptoms and patient-related events. Dexmedetomidine is an emerging sedative and hypotensive agent that has demonstrated safety and efficacy in perioperative care of other craniofacial procedures.</p><p><strong>Material and methods: </strong>An electronic search was performed in seven primary databases (Cochrane Library, Embase, LILACS, MedLine via PubMed, SciELO, Scopus, and Web of Science) and one additional (EASY) to partially capture the gray literature. The PICO strategy was used to identify randomized clinical trials evaluating the effect of dexmedetomidine on perioperative events in patients undergoing orthognathic surgery compared to placebo or control groups, without restrictions on publication language and year. Two independent reviewers performed data extraction and assessed the risk of bias using the RoB 2.0 tool.</p><p><strong>Results: </strong>The search identified 401 records, of which six studies met the eligibility criteria, including 282 patients from five countries, and published between 2008 and 2023. Outcomes were categorized into six groups based on available data: 1) Airway and Respiratory Events, 2) Emetic Events, 3) Hemodynamic Events, 4) Length of Hospital Stay, 5) Neurological Events, and 6) Pain Burden. Dexmedetomidine reduced coughing and maintained hemodynamic stability but did not prevent emergence agitation. It was associated with lower intraoperative fentanyl use and reduced rescue analgesia requirements. Postoperatively, dexmedetomidine effectively controlled pain, nausea, and vomiting, with significantly lower pain scores and reduced analgesic demand. Among the six studies, only one was classified as high risk of bias due to issues in the randomization process, while the others were categorized as low risk of bias. A meta-analysis was planned but could not be conducted due to high heterogeneity among studies.</p><p><strong>Conclusions: </strong>Dexmedetomidine appears to be a safe and effective option for reducing postoperative symptoms such as pain, nausea, vomiting, and cough in orthognathic surgery, while maintaining hemodynamic stability.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e798-e813"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of oral and oropharyngeal cancer in the Basque Country (Spain) from 1986-1994 to 2012-2017.","authors":"I Amezaga-Fernandez, X Marichalar-Mendia, I Lafuente-Ibáñez-de-Mendoza, A López-de-Munain-Marqués, J-M Aguirre-Urizar","doi":"10.4317/medoral.27518","DOIUrl":"10.4317/medoral.27518","url":null,"abstract":"<p><strong>Background: </strong>The Basque Country (Spain) is one of the European regions with the highest incidence of oral and oropharyngeal cancer, which still shows an unacceptably poor prognosis. The aim of this study was to update the epidemiological and prognostic data on oral cancer in the Basque Country and to analyse its evolution with respect to a previous study carried out in 1986-1994.</p><p><strong>Material and methods: </strong>This retrospective study included all cases diagnosed with oral and oropharyngeal cancer in the Basque Country from 2012 to 2017, obtained from the Cancer Population Registry. Descriptive analysis of the epidemiological data on oral-oropharyngeal cancer and survival analysis of oral squamous cell carcinoma were performed.</p><p><strong>Results: </strong>A total of 1,762 cases of oral-oropharyngeal cancer were analysed. The crude incidence was 7.21 cases in women and 18.07 in men. We recognised an increase in females, older patients and gingival neoplasms. Squamous cell carcinomas accounted for 92.6% of the tumours, with 70.4% affecting males, 91.8% living in urban areas, and 50.2% diagnosed at advanced stages. The overall 5-year survival rate for oral-oropharyngeal cancer in the Basque Country was 50.2%.</p><p><strong>Conclusions: </strong>Oral and oropharyngeal cancer incidence in the Basque Country has decreased overall, although it shows a progressive increase in women, older people and tumours located in the gingiva. The prognosis of oral cancer in the Basque Country is still very poor, thus it is necessary to implement specific preventive and diagnostic protocols to improve it.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e925-e933"},"PeriodicalIF":2.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}