Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years.

IF 2.1 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Medicina Oral Patologia Oral Y Cirugia Bucal Pub Date : 2025-07-01 DOI:10.4317/medoral.27164

C Li, Z Gong, S Jumatai, C Fang, P Pataer, H Zhao

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引用次数: 0

Abstract

Background: Osteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aimed to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario.

Material and methods: A cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020. A total of 106 patients were divided into normal wound healing group (n = 79) and delayed wound healing group (n = 27) according to two different prognosis. The risk factors associated with the prognosis in patients with ORNJ were comparatively analyzed via performing one-way and multifactorial logistic analyses.

Results: The majority of the study cohort (n = 59, 55.7%) was found to be characterized with Glanzmann and Gratz grade 2 and followed up for a median of 38.6 months. Diabetes mellitus (P = .045), Charlson comorbidity index (P = .042), American Society of Anesthesiologists score (P < .001), primary tumour site (P = .012), T stage (P = .008), ORNJ grade at initial diagnosis (P < .001), pan-immune-inflammatory value and systemic immune-inflammatory index at initial radiotherapy (P = .01 and P < .001 respectively) were detected as risk factors associated with poor prognosis in patients with ORNJ.

Conclusions: We conclude that there are abundant risk factors for poor prognosis in these patients, and it is important to be evaluated before irradiation so that suitable post-radiated treatments can be given.

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与颌骨放射性骨坏死患者预后相关的危险因素：超过15年的单一机构经验。

背景：颌骨放射性骨坏死（ORNJ）是放射治疗的一种恶性并发症，严重影响头颈癌患者的生活质量。本研究旨在探讨在相同情况下影响ORNJ临床预后的危险因素。材料与方法：本研究于2005年1月至2020年12月在某三级教学医院设计并实施横断面研究。106例患者根据预后不同分为创面正常愈合组（79例）和创面延迟愈合组（27例）。通过单因素和多因素logistic分析，比较分析影响ORNJ预后的危险因素。结果：大多数研究队列（n = 59, 55.7%）被发现为Glanzmann和Gratz 2级，随访时间中位数为38.6个月。糖尿病（P = 0.045）、Charlson合病指数（P = 0.042）、美国麻醉医师学会评分（P < 0.001）、原发肿瘤部位（P = 0.012）、T分期（P = 0.008）、初诊时ORNJ分级（P < 0.001）、初放疗时泛免疫炎性值和全身免疫炎性指数（P = 0.01和P < 0.001）是ORNJ预后不良的危险因素。结论：这些患者预后不良的危险因素较多，放疗前应进行评估，以便给予适当的放疗后治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Oral Patologia Oral Y Cirugia Bucal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology