Medicina Oral Patologia Oral Y Cirugia Bucal最新文献

{"title":"Emotional regulation, empathy and surgical performance inundergraduate dental students: A prospective cohort study.","authors":"A-B Pérez, I-M Mayoral, C de-la-Rosa-Gay, M-G García, M Aguilera, R Figueiredo, E Valmaseda-Castellón, A Sánchez-Torres","doi":"10.4317/medoral.27960","DOIUrl":"10.4317/medoral.27960","url":null,"abstract":"<p><strong>Background: </strong>Dental students experience high stress from academic and clinical demands, which may affect performance and well-being. Surgical procedures often increase patient anxiety, adding complexity for students. This study explored the relationship between perceived difficulty, emotional regulation, and empathy, and their impact on clinical outcomes and patient satisfaction.</p><p><strong>Material and methods: </strong>A prospective cohort study included fourth-year dental students in the Clinical Oral Surgery and Implantology subject at the University of Barcelona Dental Hospital. Data collected comprised demographics, emotional regulation difficulties, and preoperative anxiety, using validated questionnaires. Procedure-related variables (perceived difficulty, operative time, complications) and patient data (anxiety, perceived empathy, satisfaction) were recorded.</p><p><strong>Results: </strong>Thirty-six students performed 108 extractions on 72 patients, with a mean operative time of 38.2±19.9 minutes. Emotional regulation difficulties were not associated with surgical difficulty, empathy, operative time, or complications. Interestingly, patient state anxiety was significantly related to higher difficulty on emotional regulation by the undergraduate. No significant correlation was found between patient anxiety and number of visits. Perceived empathy positively correlated to patient satisfaction.</p><p><strong>Conclusions: </strong>Empathy and emotional regulation are essential for enhancing patient experience and outcomes. Our findings suggest that students' emotional regulation difficulties are related to situational anxiety during clinical encounters. These results support integrating interpersonal skills into dental education to improve clinical practice and patient-centered care.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of salivary IL-4 and CXCL6 dynamics following tooth extraction in diabetic and non-diabetic patients.","authors":"M-A Alsaegh, Y-I Shehhi, S-R Shetty, O Mahmoud, J-K Narayanan, S-R Varma","doi":"10.4317/medoral.28058","DOIUrl":"10.4317/medoral.28058","url":null,"abstract":"<p><strong>Background: </strong>Tooth extraction initiates a regulated inflammatory healing response. Diabetes mellitus may alter this early tissue response; however, data on early salivary cytokine and chemokine changes after extraction in diabetic individuals remain limited. Therefore, this study aimed to compare early postoperative salivary interlukine-4 (IL-4) and CXC motif chemokine ligand 6 (CXCL6) dynamics following tooth extraction in diabetic and non-diabetic individuals.</p><p><strong>Material and methods: </strong>A prospective cohort study was conducted including 30 participants, comprising 20 individuals with controlled type 2 diabetes mellitus and 10 healthy controls. Unstimulated whole saliva was collected at three time points: Before extraction, 1 hour post-extraction and 2 days post-extraction. Salivary IL-4 and CXCL6 concentrations were measured using a Luminex multiplex assay. A two-way repeated-measures ANOVA was applied to examine within-subject temporal effects and between-group differences, as well as their interaction.</p><p><strong>Results: </strong>IL-4 levels did not show significant changes over time (p=0.453) and did not differ between diabetic and non-diabetic participants (p=0.221), with no significant time-by-group interaction (p=0.526). In contrast, CXCL6 demonstrated a significant effect of time (p=0.035) and a significant time-by-group interaction (p=0.043), indicating distinct temporal response patterns between groups, although overall CXCL6 levels did not differ significantly between diabetic and control participants.</p><p><strong>Conclusions: </strong>Early post-extraction healing in diabetes demonstrates altered inflammatory kinetics. While salivary IL-4 remained stable within the first 48 hours, CXCL6 exhibited significant time and group-dependent modulation, indicating dysregulated early inflammatory responses.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147373346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cone-beam CT evaluation of impacted mandibular third molars and their possible association with mandibular incisor crowding.","authors":"M-P Akkitap","doi":"10.4317/medoral.27823","DOIUrl":"10.4317/medoral.27823","url":null,"abstract":"<p><strong>Background: </strong>The relationship between impacted mandibular third molars and mandibular incisor crowding remains controversial. This study aimed to evaluate whether the impaction pattern of mandibular third molars is associated with lower incisor crowding using cone-beam computed tomography (CBCT).</p><p><strong>Material and methods: </strong>A retrospective sample of 140 patients was analyzed, including 70 with unilateral and 70 with bilateral mandibular third molar impactions. Little's Irregularity Index (LII) was measured on CBCT images to quantify incisor crowding. Arch length, depth, intercanine width, and intermolar width were also recorded. Non-parametric tests were used to compare groups, and intra-observer repeatability was assessed.</p><p><strong>Results: </strong>The mean LII was 9.0±4.8, with 85% of patients showing some degree of crowding. Bilateral impaction cases presented significantly higher LII scores than unilateral cases (p=0.047). However, no significant differences were found in arch dimensions between groups, and LII was not associated with gender or age. Categorical analysis of crowding prevalence did not differ significantly between unilateral and bilateral groups.</p><p><strong>Conclusions: </strong>Bilateral mandibular third molar impaction showed a weak association with greater mandibular incisor irregularity. Crowding is a multifactorial condition, and CBCT may provide additional insight into its assessment in patients with impacted third molars.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e330-e335"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of collagen hemostatic membrane and sponge in alveolar sockets: A quasi-experimental prospective clinical study.","authors":"L-L Sousa, F-P Faco, L-G Fiorin, T-H Skiba, J-C Fernandes, G-V Fernandes, S-C Martins, H-D Pereira-da-Silva","doi":"10.4317/medoral.27642","DOIUrl":"10.4317/medoral.27642","url":null,"abstract":"<p><strong>Background: </strong>This prospective split-mouth clinical study aimed to compare and evaluate bleeding, soft tissue healing, and pain management following tooth extractions using either the Lumina Coat® membrane or the Hemospon® sponge.</p><p><strong>Material and methods: </strong>Thirty-two alveoli were included in this study. Following extraction, the sockets were filled with one of two materials: the Hemospon® collagen sponge (control group) or the Lumina Coat® collagen membrane (test group). Participants were assessed at 30 minutes, 24 hours and 48 hours postoperatively to evaluate bleeding, and were then recalled after 7 days for clinical assessment of soft tissue healing and suture removal. Soft tissue healing and bleeding were scored on a 0-3 scale, while pain was assessed using the visual analog scale (VAS). Data were expressed as means with standard deviations and analyzed using Prism 9 (GraphPad Software).</p><p><strong>Results: </strong>During the later postoperative period, pain scores decreased in both groups. Initial pain scores were 2.20 in the Lumina Coat group and 2.80 in the Hemospon group. By day 7, both groups reported an average score of 0.25 (p>0.05). Bleeding scores were elevated in both groups in the early postoperative phase. The Lumina Coat group had an average score of 1.35, compared with 1.65 in the Hemospon group. Scores decreased progressively over the first 24 hours, after which bleeding resolved completely. A statistically significant difference was observed at 30 minutes, with the Lumina Coat group showing lower scores (average 0.75) compared with the Hemospon group (average 1.20). Healing scores followed a similar pattern-higher in the immediate postoperative period but declining after 7 days. At 2 days postoperatively, the Lumina Coat group demonstrated significantly lower healing scores (average 0.35) than the Hemospon group (average 0.80).</p><p><strong>Conclusions: </strong>Both materials were effective in controlling pain, reducing bleeding, and promoting soft tissue healing. However, the Lumina Coat group showed superior outcomes compared to Hemospon, particularly in reducing bleeding and improving healing scores.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e146-e154"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified sagittal split osteotomy of the mandibular ramus: A single-cut approach for orthognathic surgery.","authors":"S-M Costa, M-S Bahia, M-Y Kadooka, P-F Trivellato, C-E Sverzut, A-E Trivellato","doi":"10.4317/medoral.27649","DOIUrl":"10.4317/medoral.27649","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the feasibility, and reliability of a novel simplified sagittal osteotomy (SSO) technique for mandibular repositioning in orthognathic surgery. The research question focuses on whether this approach can reduce technical complexity and complication rates, especially in a residency training environment.</p><p><strong>Material and methods: </strong>A prospective observational study was conducted involving 118 patients (62 females, 56 males) diagnosed with Angle Class II or III malocclusions and indicated for orthognathic surgery. All patients underwent a novel mandibular osteotomy as part of a Double-jaw surgery. Exclusion criteria included patients under 18 years of age, third molar presence, mandibular pathologies, and incomplete follow-up. The primary outcomes included feasibility, complication rates, and the need for conversion to the conventional BSSO. Statistical analysis was performed using the Chi-square test.</p><p><strong>Results: </strong>A total of 236 osteotomies were performed. The technique was considered feasible in 98.7% of cases, with no conversions to traditional BSSO. No bad splits occurred. IAN injury was observed in 0.8% of cases, and long-term paresthesia (>1 year) occurred in 1.2%. No cases of hemorrhage or dental injury were reported. No significant associations were found between complications and patient gender or deformity type (p>0.05).</p><p><strong>Conclusions: </strong>The SSO technique demonstrated high feasibility and a low complication profile, supporting its use as a reliable alternative to BSSO.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e155-e159"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based approach for differential diagnosis of odontogenic cysts from histopathological images.","authors":"D Torul, I-S Bayrakdar, M-H Bozkurt, H Erdem, M Akcay-Celik, B Ersan-Erdem, F-G Salman","doi":"10.4317/medoral.27697","DOIUrl":"10.4317/medoral.27697","url":null,"abstract":"<p><strong>Background: </strong>This study aims to provide Deep Learning (DL) based artificial intelligence (AI) methods using histopathology images to diagnose different types of odontogenic cysts (OCs) differentially.</p><p><strong>Material and methods: </strong>Within the scope of the proposed study, hematoxylin and eosin (H&E) stained images of 3 different cyst groups were used. The dataset consists of histopathology images of 87 Dentigerous cysts (DC), 198 radicular cyst (RC), and 63 odontogenic keratocyst (OKC). Each image was zoomed with 3 different zoom levels and resized to 224x224 as preprocessing. In addition to the classical CNN method, Inception V3, VGG16, VGG19, and Xception architectures were used. The data set was split into training, validation, and test groups to avoid retesting.</p><p><strong>Results: </strong>The average accuracy, precision, sensitivity (recall), and F1-Score values obtained for CNN were 0.77, 0.80, 0.77, 0.75, and for VGG16 were 0.89, 0.90, 0.89, 0.89. For VGG19, these values were determined as 0.89, 0.90, 0.89, and 0.88, for Xception, these values were determined as 0.62, 0.52, 0.62,and 0.52 and for Inception, these values were determined as 0.62, 0.62, 0.62 and 0.56.</p><p><strong>Conclusions: </strong>It was observed that VGG16 and VGG19 models showed superior performance on the data set in question, while Xception and Inception V3 models converged slower, meaning the training process progressed slower. Results showed that deep neural networks can be efficiently used in detecting OCs. AI-based OC detection may be a decision support tool that reduces interprofessional variability, expedites the diagnostic process, and lessens clinician workload.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e196-e204"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncologic safety of autologous fat grafting in head and neck cancer patients: A scoping review.","authors":"M-A Correas, G-C Ferrer, J-G Martín-Moro, M-J Soto, J-L Carretero","doi":"10.4317/medoral.27795","DOIUrl":"10.4317/medoral.27795","url":null,"abstract":"<p><strong>Background: </strong>Autologous fat grafting (AFG) has become increasingly used in reconstructive surgery due to its accessibility, safety, and regenerative potential. In head and neck cancer (HNC) patients, however, concerns remain regarding its oncologic safety, particularly due to the presence of adipose-derived stem cells (ASCs), which may theoretically influence tumor recurrence. This scoping review aims to synthesize current evidence regarding the safety of AFG in this unique patient population.</p><p><strong>Material and methods: </strong>The review was conducted following the PRISMA-ScR guidelines. PubMed and Scopus databases were searched up to December 2024 using the terms \"autologous fat grafting,\" \"lipofilling,\" \"head and neck cancer,\" and \"oncologic safety.\" Eligible studies included clinical or experimental works reporting on AFG in HNC patients with oncologic outcome assessment. Exclusion criteria included purely aesthetic procedures and studies without relevance to oncologic safety. Data were extracted on study design, patient population, fat grafting technique, follow-up, and reported oncologic outcomes.</p><p><strong>Results: </strong>Five key studies fulfilled the inclusion criteria: A multinational survey of surgeons (Fiedler et al., 2021), a retrospective cohort study of parotidectomy patients (Boschetti et al., 2023), a narrative review on craniofacial oncologic patients (Drochioi et al., 2019), a retrospective series of 116 patients (190 procedures) (Kamali et al., 2018) and a retrospective cohort with radiation-induced fibrosis (Griffin et al., 2019). Across these works, no evidence of increased recurrence or metastasis following AFG was reported. Favorable functional and aesthetic outcomes were consistently observed, although methodological variability and short follow-up durations limited the robustness of conclusions.</p><p><strong>Conclusions: </strong>Current evidence suggests that AFG is oncologically safe and beneficial for reconstructive purposes in head and neck cancer patients, improving contour and tissue quality. Nevertheless, the lack of large, prospective, and long-term studies precludes definitive recommendations. Standardized protocols and extended oncologic follow-up are essential to confirm safety and guide future clinical practice.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e324-e329"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal physiotherapeutic management of postoperative complications in orthognathic surgery: A literature review and institutional protocol proposal.","authors":"A Fernández-de-la-Reguera, A Muñoz, O Sotelo, X Toledo","doi":"10.4317/medoral.27687","DOIUrl":"10.4317/medoral.27687","url":null,"abstract":"<p><strong>Background: </strong>Orthognathic surgery (OS) corrects skeletal and dental discrepancies in the maxillofacial region, improving occlusion, masticatory function, respiration, and facial aesthetics. However, the immediate and intermediate postoperative periods are frequently associated with acute pain, facial edema, neurosensory disturbances (e.g., paresthesia of the inferior alveolar and/or infraorbital nerves), and restricted mandibular mobility (trismus), which may prolong recovery and impair quality of life. Physiotherapeutic rehabilitation has emerged as a key component of postoperative care, yet standardized guidance remains limited. The objective is to present a standardized, evidence-based physiotherapeutic protocol for managing common postoperative complications after OS, aiming to optimize functional recovery and reduce morbidity.</p><p><strong>Material and methods: </strong>A narrative review of the literature on postoperative physiotherapeutic rehabilitation in OS was conducted, focusing on interventions for pain, edema, neurosensory disturbances, trismus, and bone healing. The protocol was developed within the Postgraduate Program in Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, University of Chile, integrating current evidence and clinical experience.</p><p><strong>Results: </strong>The protocol proposes multimodal strategies-including photobiomodulation, manual therapy, and therapeutic exercises-to address the most frequent postoperative complications. Evidence supports early, structured, and systematic intervention to improve analgesia, accelerate edema resolution, enhance neurosensory recovery, increase mandibular mobility, and promote bone healing.</p><p><strong>Conclusions: </strong>Early, structured physiotherapeutic management is fundamental to postoperative care in OS. The proposed protocol offers a replicable, evidence-based framework to facilitate optimal recovery and functional reintegration.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e191-e195"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser treatment of oral vascular anomalies. A retrospective observational study.","authors":"L Monteiro, C Fazendeiro, S Ferreira, L Delgado, J-J Pacheco, F Salazar","doi":"10.4317/medoral.27681","DOIUrl":"10.4317/medoral.27681","url":null,"abstract":"<p><strong>Background: </strong>Oral vascular anomalies, though benign, may impact comfort and aesthetics, particularly in visible or functional areas. Laser therapies have gained prominence due to their precision, minimal invasiveness, and favourable outcomes. This study aimed to analyse the laser treatment modalities for oral vascular anomalies and their respective outcomes in a population of the north of Portugal.</p><p><strong>Material and methods: </strong>This retrospective study analysed 111 vascular anomalies in 95 patients treated between January 2011 and May 2025 in the University Clinics of IUCS-CESPU. Data on demographics, type and location of vascular anomalies, treatment (Nd:YAG, CO2 or diode laser), and outcomes were collected.</p><p><strong>Results: </strong>Venous lakes were the most frequent diagnosis (n=77;69.4%) and lip was the most common location (n=81;73%). Induced photocoagulation (IPC) (n=79;71.2%), essentially with Nd:YAG, was the predominant technique. Recurrence was observed in 4 cases (3.6%), healing occurred mostly ≤21 days (n=88; 79.3%), scar tissue was present in 10 cases (9%), pain was reported in 29 patients (26.1%) (mean of 0.85±0.14), and satisfaction was high (n=103; 92.8%). No major complications were observed. Logistic regression analysis showed that larger vascular anomalies were associated with delayed healing (p=0.009) and scar formation correlated with presence of pain (one day after intervention) (p=0.03) and recurrence (p=0.039).</p><p><strong>Conclusions: </strong>Laser-based management in particular, IPC, is a safe, effective, and well tolerated option for the treatment of small oral vascular anomalies. Prospective studies are encouraged to optimize protocols and standardize the technique.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e180-e190"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of surgical margins on recurrence and survival rate in patients with oral squamous cell carcinoma: A systematic review and meta-analysis.","authors":"A Rubert, L Bagan, A Proaño, G Sarrion, J Bagan","doi":"10.4317/medoral.27784","DOIUrl":"10.4317/medoral.27784","url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of malignant neoplasms of the oral cavity. At early stages, the treatment of choice is surgical resection with clear margins, commonly defined as ≥5mm of tumor-free tissue. However, the optimal surgical margin in relation to recurrence and survival remains controversial. The objective of this study was to evaluate the impact of surgical margin status on local recurrence and overall survival in patients with OSCC through a meta-analysis.</p><p><strong>Material and methods: </strong>An electronic search was conducted in Medline-PubMed, Web of Science, and Scopus up to January 2025. Two investigators independently selected the studies according to the inclusion criteria. The study included prospective and retrospective studies assessing patients with oral squamous cell carcinoma who underwent surgical treatment and reported data regarding surgical margin status, recurrence rates, and survival outcomes. The Newcastle-Ottawa Scale was used for non-randomized observational studies. Odds ratios were estimated with 95% confidence intervals, and forest plots were generated using random-effects or fixed-effects meta-analyses depending on heterogeneity. Sensitivity analyses and publication bias analyses were performed using funnel plots and Egger's test. All statistical analyses were conducted using Comprehensive Meta-Analysis software, version 3.0.</p><p><strong>Results: </strong>Positive margins (<5mm) were significantly associated with a higher rate of local recurrence (OR=2.72; 95% CI: 2.04-3.62; p<0.001), while negative margins (≥5mm) were linked to a 1.58 -fold increase in the probability of 5-year survival (RR=0.63; 95% CI: 0.55-0.74; p<0.001).</p><p><strong>Conclusions: </strong>Surgical margin status is a prognostic factor for locoregional control and overall survival in OSCC. A cutoff value of ≥5mm is proposed as the optimal surgical margin.</p>","PeriodicalId":49016,"journal":{"name":"Medicina Oral Patologia Oral Y Cirugia Bucal","volume":" ","pages":"e307-e316"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145582638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}