Nagoya Journal of Medical Science最新文献_第7页

Comparison of the influenza vaccination coverage among high-risk people between the online registration system and walk-in service system in Bangkok, Thailand. 泰国曼谷在线登记系统与上门服务系统在高危人群中的流感疫苗接种覆盖率比较。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.252

Ranai Sairuk, Kimihiro Nishino, Souphalak Inthaphatha, Nobuyuki Hamajima, Eiko Yamamoto

{"title":"Comparison of the influenza vaccination coverage among high-risk people between the online registration system and walk-in service system in Bangkok, Thailand.","authors":"Ranai Sairuk, Kimihiro Nishino, Souphalak Inthaphatha, Nobuyuki Hamajima, Eiko Yamamoto","doi":"10.18999/nagjms.86.2.252","DOIUrl":"10.18999/nagjms.86.2.252","url":null,"abstract":"Until recently, the Thai national program of seasonal influenza vaccination for high-risk people has been using a walk-in service system. However, in 2020, an online registration system was introduced in Bangkok to improve vaccine coverage. This study aimed to compare the coverage of influenza vaccination between the walk-in service and online registration systems. The study participants included 374,710 Thai individuals who obtained an influenza vaccination from the national program in the Bangkok health region in 2018 (n = 162,214) and in 2020 (n = 212,496). The registration systems that were examined were the walk-in service system in 2018 and the online registration system in 2020. The characteristics of vaccine recipients and the vaccine coverage in each risk group and health facility level were compared between the two systems. Coverage comparison in Bangkok between the years 2018 and 2020 showed an increase in coverage, particularly among individuals who had an influenza vaccination at health facilities of the primary level and in the elderly and obesity groups. The coverage among children was lowest among all high-risk groups. To improve coverage in Thailand, the online registration system should be introduced in all regions. Additionally, information about influenza vaccination for children should be disseminated to parents using handbooks or by word-of-mouth from healthcare workers.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"252-261"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of the chronic obstructive pulmonary disease self-care assessment scale: a concise and comprehensive instrument to assess self-management, decision-making, and coping. 慢性阻塞性肺病自我护理评估量表的开发和验证：评估自我管理、决策和应对能力的简明综合工具。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.201

Sanae Iwaya, Kazuki Sato

{"title":"Development and validation of the chronic obstructive pulmonary disease self-care assessment scale: a concise and comprehensive instrument to assess self-management, decision-making, and coping.","authors":"Sanae Iwaya, Kazuki Sato","doi":"10.18999/nagjms.86.2.201","DOIUrl":"10.18999/nagjms.86.2.201","url":null,"abstract":"The purpose of this study was to develop and test the reliability and validity of a brief and comprehensive instrument to assess self-management, decision-making, and coping by chronic obstructive pulmonary disease (COPD) patients. A web-based questionnaire was administered to 300 COPD patients and a retest was administered to 100 COPD patients. Cronbach's alpha was used to assess internal consistency, and an intraclass correlation coefficient was calculated to test the reliability of the retest. The convergent and discriminant validities were also examined. Valid responses were obtained from 279 participants in the first survey and 70 participants in the retest. From our analysis, a COPD self-care assessment scale (CSCS) was developed, consisting of seven subscales and 14 items. Cronbach's alpha for the total CSCS score, intraclass correlation coefficient, and scale success rate were 0.80, 0.79, and 100%, respectively. A multivariate analysis showed that CSCS was associated with current smoking (standardized partial regression coefficient [std β] = -0.30; p < 0.001), long-term oxygen therapy (std β = 0.23; p < 0.001), and social support (std β = 0.24; p < 0.001), but not psychological symptoms or quality of life. The CSCS is also useful in assessing self-management, decision-making, and coping in Japanese COPD patients, and the scale has high reliability and validity.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"201-215"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender and age variations in the association between multigenerational cohabitation and self-rated health among middle-aged and older adults in Japan. 日本中老年人多代同居与自评健康之间的性别和年龄差异。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.262

Akane Nogimura, Takahiro Otani, Taiji Noguchi, Hiroko Nakagawa-Senda, Miki Watanabe, Tamaki Yamada, Sadao Suzuki

{"title":"Gender and age variations in the association between multigenerational cohabitation and self-rated health among middle-aged and older adults in Japan.","authors":"Akane Nogimura, Takahiro Otani, Taiji Noguchi, Hiroko Nakagawa-Senda, Miki Watanabe, Tamaki Yamada, Sadao Suzuki","doi":"10.18999/nagjms.86.2.262","DOIUrl":"10.18999/nagjms.86.2.262","url":null,"abstract":"Despite encouraging multi-generational cohabitation, the population of Japanese people living alone has increased. However, little is known about the association between health and multigenerational cohabitation. This study examined the relationship between self-rated health and living arrangements among Japanese adults using data from the Japan Multi-Institutional Collaborative Cohort Study (2013-2017). The analysis employed multivariate logistic regression to examine the associations. Our results showed no association between living arrangements and self-rated health when stratified by gender. Living alone was found to be associated with poor self-rated health among women aged 65 and above. A similar association may exist among men in the same age group. Among women aged < 65 years, two-generation cohabitation was associated with a good self-rated health, similar to those living alone. Among men aged < 65 years, neither living alone nor two-generation cohabitation was significantly associated with good self-rated health. We found no association between three- or plus-generation cohabitation and self-rated health. Therefore, our findings indicate associations between multigenerational cohabitation and self-rated health, but they vary by gender and age. Invested stakeholders in the public health field should consider the potential impact of living arrangements on health based on gender and age.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"262-279"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of surgical treatment for enterovesical fistula in Crohn's disease. 手术治疗克罗恩病肠瘘的效果。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.280

Norifumi Hattori, Goro Nakayama, Shinichi Umeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Koki Nakanishi, Dai Shimizu, Mitsuro Kanda, Masamichi Hayashi, Chie Tanaka, Yasuhiro Kodera

{"title":"Outcomes of surgical treatment for enterovesical fistula in Crohn's disease.","authors":"Norifumi Hattori, Goro Nakayama, Shinichi Umeda, Masanao Nakamura, Takeshi Yamamura, Tsunaki Sawada, Koki Nakanishi, Dai Shimizu, Mitsuro Kanda, Masamichi Hayashi, Chie Tanaka, Yasuhiro Kodera","doi":"10.18999/nagjms.86.2.280","DOIUrl":"10.18999/nagjms.86.2.280","url":null,"abstract":"Enterovesical fistula (EVF) in Crohn's disease (CD) often does not improve with medical treatment and requires surgical treatment. The surgical treatment strategy for EVF in CD is definitive resection of the intestinal tract side, and performing a leak test using dye injection into the bladder after EVF dissection to determine the appropriate surgical procedure for the bladder side. This study aimed to evaluate the outcomes of surgical treatment for EVF in CD. Twenty-one patients who underwent surgery for EVF between 2006 and 2021 were included and retrospectively evaluated for clinical background, surgical procedures, and postoperative complications. The most common origin of EVF was the ileum (17 cases; 81%), and the most common site of EVF formation was the apex (12; 57%). Surgical approaches were laparotomy in 11 (52%) cases and laparoscopy in 10 (48%). Surgical procedures on the bladder side were fistula dissection in 13 (62%) cases and sutured closure of fistula in 8 (38%). A comparison of approaches revealed no significant difference in operative time, but the amount of blood loss was significantly less in the laparoscopy (p < 0.01). There was no significant difference in the occurrence of postoperative complications between approaches. Postoperative anti-TNF-α antibody agents were used in 17 (81%) cases, and there were no cases of recurrent EVF. In conclusion, definitive resection of the intestinal tract and minimal treatment on the bladder side were sufficient to achieve satisfactory outcomes for EVF in CD.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"280-291"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment escalation and de-escalation of de-novo metastatic castration-sensitive prostate cancer. 新发转移性阉割敏感性前列腺癌的治疗升级和降级。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.169

Shusuke Akamatsu, Yushi Naito, Jun Nagayama, Yuta Sano, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Shohei Ishida, Yoshihisa Matsukawa, Masashi Kato

{"title":"Treatment escalation and de-escalation of de-novo metastatic castration-sensitive prostate cancer.","authors":"Shusuke Akamatsu, Yushi Naito, Jun Nagayama, Yuta Sano, Satoshi Inoue, Kazuna Matsuo, Tomoyasu Sano, Shohei Ishida, Yoshihisa Matsukawa, Masashi Kato","doi":"10.18999/nagjms.86.2.169","DOIUrl":"10.18999/nagjms.86.2.169","url":null,"abstract":"Androgen receptor signaling inhibitors combined with androgen deprivation therapy have become the standard of care for metastatic castration-sensitive prostate cancer (mCSPC), regardless of tumor volume or risk. However, survival of approximately one-third of these patients has not improved, necessitating further treatment escalation. On the other hand, for patients with oligometastatic mCSPC, there is an emerging role for local radiation therapy. Although data remain scarce, it is expected that treatment of both primary tumor as well as metastasis-directed therapy may improve survival outcomes. In these patients, systemic therapy may be de-escalated to intermittent therapy. However, precise risk stratification is necessary for risk-based treatment escalation or de-escalation. In addition to risk stratification based on clinical parameters, research has been conducted to incorporate genomic and/or transcriptomic data into risk stratification. In future, an integrated risk model is expected to precisely stratify patients and guide treatment strategies. Here, we first review the transition of the standard treatment for mCSPC over the last decade and further discuss the newest concept of escalating or de-escalating treatment using a multi-modal approach based on the currently available literature.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"169-180"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uneventful vaginal delivery using epidural anesthesia in patient with exercise induced anaphylaxis: a case report and literature review. 在运动诱发过敏性休克患者中使用硬膜外麻醉进行无痛阴道分娩：病例报告和文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.345

Kanon Morimoto, Kenichiro Tatsumi, Yoshitsugu Chigusa, Maya Komatsu, Moritoki Egi, Masaki Mandai, Haruta Mogami

{"title":"Uneventful vaginal delivery using epidural anesthesia in patient with exercise induced anaphylaxis: a case report and literature review.","authors":"Kanon Morimoto, Kenichiro Tatsumi, Yoshitsugu Chigusa, Maya Komatsu, Moritoki Egi, Masaki Mandai, Haruta Mogami","doi":"10.18999/nagjms.86.2.345","DOIUrl":"10.18999/nagjms.86.2.345","url":null,"abstract":"Exercise induced anaphylaxis (EIA) is a rare and potentially life-threatening syndrome characterized by anaphylaxis provoked by exercise. Although vaginal delivery with labor pain is a physical strain for women and a possible trigger for EIA, no consensus exists on the management strategy of delivery in patients with EIA. A 28-year-old primigravida was referred to our hospital because of history of EIA, associated with pruritus, urticaria, and respiratory distress, exacerbated during physical activity. To avoid physical stress, we chose scheduled labor induction with epidural anesthesia, and administered prophylactic intravenous hydrocortisone. She delivered vaginally with no symptoms suggestive of EIA during labor. Since it is quite possible for patients with EIA to develop anaphylaxis during vaginal delivery with labor pain, epidural anesthesia and prophylactic steroid administration may be the most rational approaches for delivery in pregnant women with EIA.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"345-350"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population. 日本人群中部分 3q29 区域基因与精神分裂症和自闭症谱系障碍之间的遗传关联研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.216

Gantsooj Otgonbayar, Tzuyao Lo, Yu Hayashi, Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Itaru Kushima, Hidekazu Kato, Hiroki Kimura, Norio Ozaki

{"title":"Study of the genetic association between selected 3q29 region genes and schizophrenia and autism spectrum disorder in the Japanese population.","authors":"Gantsooj Otgonbayar, Tzuyao Lo, Yu Hayashi, Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Itaru Kushima, Hidekazu Kato, Hiroki Kimura, Norio Ozaki","doi":"10.18999/nagjms.86.2.216","DOIUrl":"10.18999/nagjms.86.2.216","url":null,"abstract":"Psychiatric disorders are highly inheritable, and most psychiatric disorders exhibit genetic overlap. Recent studies associated the 3q29 recurrent deletion with schizophrenia (SCZ) and autism spectrum disorder (ASD). In this study, we investigated the association of genes in the 3q29 region with SCZ and ASD. TM4SF19 and PAK2 were chosen as candidate genes for this study based on evidence from previous research. We sequenced TM4SF19 and PAK2 in 437 SCZ cases, 187 ASD cases and 524 controls in the Japanese population. Through targeted sequencing, we identified 6 missense variants among the cases (ASD & SCZ), 3 missense variants among controls, and 1 variant common to both cases and controls; however, no loss-of-function variants were identified. Fisher's exact test showed a significant association of variants in TM4SF19 among cases (p=0.0160). These results suggest TM4SF19 variants affect the etiology of SCZ and ASD in the Japanese population. Further research examining 3q29 region genes and their association with SCZ and ASD is thus needed.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"216-222"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital-associated complications in frail older adults. 年老体弱者的医院相关并发症。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.181

Hiroyuki Umegaki

{"title":"Hospital-associated complications in frail older adults.","authors":"Hiroyuki Umegaki","doi":"10.18999/nagjms.86.2.181","DOIUrl":"10.18999/nagjms.86.2.181","url":null,"abstract":"As the Japanese population continues to age steadily, the number of older adults requiring healthcare has increased. Evidence demonstrates that hospitalization for acute care has a negative impact on the health outcomes of older adults. Frail older adults tend to have multifactorial conditions collectively known as \"geriatric syndromes.\" When those with these premorbid conditions are hospitalized for acute care, they tend to develop new problems such as delirium and new functional impairments. Adverse consequences of hospitalization include the risk of loss of functional independence and chronic disability. In 2019, the new concept of \"hospital-associated complications\" (HACs) was proposed to describe these new problems. HACs comprise five conditions: hospital-associated falls, delirium, functional decline, incontinence, and pressure injuries. This review discusses the important issues of HACs in relation to their classification, prevalence, risk factors, prevention, and management in older adults hospitalized for acute care. Robust prevention and management are imperative to address the serious consequences and escalating medical costs associated with HACs, and a multidimensional and multidisciplinary approach is key to achieving this goal. Comprehensive geriatric assessment (CGA) is the cornerstone of geriatric medicine and offers a holistic approach involving multidisciplinary and multidimensional assessments. Considerable evidence is accumulating regarding how CGA and coordinated care can improve the prognosis of hospitalized older adults. Further research is needed to understand the occurrence of HACs in this population and to develop effective preventive measures.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"181-188"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. 从原发性血小板增多症到急性髓性白血病的克隆进化过程，CALR 突变的 Marimo 细胞系就是从该患者身上建立起来的。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.326

Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi

{"title":"Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established.","authors":"Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi","doi":"10.18999/nagjms.86.2.326","DOIUrl":"10.18999/nagjms.86.2.326","url":null,"abstract":"We previously reported the Marimo cell line, which was established from the bone marrow cells of a patient with essential thrombocythemia (ET) at the last stage after transformation to acute myeloid leukemia (AML). This cell line is widely used for the biological analysis of ET because it harbors CALR mutation. However, genetic processes during disease progression in the original patient were not analyzed. We sequentially analyzed the genetic status in the original patient samples during disease progression. The ET clone had already acquired CALR and MPL mutations, and TP53 and NRAS mutations affected the disease progression from ET to AML in this patient. Particularly, the variant allele frequency of the NRAS mutation increased along with the disease progression after transformation, and the NRAS-mutated clone selectively proliferated in vitro, resulting in the establishment of the Marimo cell line. Although CALR and MPL mutations co-existed, MPL was not expressed in Marimo cells or any clinical samples. Furthermore, mitogen-activated protein kinase (MAPK) but not the JAK2-STAT pathway was activated. These results collectively indicate that MAPK activation is mainly associated with the proliferation ability of Marimo cells.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"326-332"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for nausea and vomiting requiring the daily administration of 5-HT₃ receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma. 放疗联合替莫唑胺治疗高级别胶质瘤时，需要每天服用 5-HT3 受体拮抗剂的恶心和呕吐风险因素。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.304

Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada

{"title":"Risk factors for nausea and vomiting requiring the daily administration of 5-HT3 receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma.","authors":"Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada","doi":"10.18999/nagjms.86.2.304","DOIUrl":"10.18999/nagjms.86.2.304","url":null,"abstract":"Radiotherapy combined with temozolomide (TMZ+RT) is the primary treatment for high-grade glioma. TMZ is classified as a moderate emetic risk agent and, thus, supportive care for nausea and vomiting is important. In Nagoya University Hospital, all patients are treated with a 5-hydroxy-tryptamine 3 receptor antagonist (5-HT3RA) for the first 3 days. The daily administration of 5-HT3RA is resumed after the 4th day based on the condition of patients during TMZ+RT. Therefore, the present study investigated risk factors for nausea and vomiting in patients requiring the daily administration of 5-HT3RA. Patients with high-grade glioma who received TMZ+RT between January 2014 and December 2019 at our hospital were included. Patients were divided into two groups: a control group (patients who did not resume 5-HT3RA) and resuming 5-HT3RA group (patients who resumed 5-HT3RA after the 4th day), and both groups were compared to identify risk factors for nausea and vomiting during TMZ+RT. There were 78 patients in the control group (68%) and 36 in the resuming 5-HT3RA group (32%). A multivariate analysis of patient backgrounds in the two groups identified age <18 years, PS 2 or more, and occipital lobe tumors as risk factors for nausea and vomiting. Nausea and vomiting were attenuated in 30 patients (83%) in the resuming 5-HT3RA group following the resumption of 5-HT3RA. The results obtained highlight the importance of extracting patients with these risk factors before the initiation of therapy and the early resumption or daily administration of 5-HT3RA according to the condition of each patient.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"304-313"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0