Nagoya Journal of Medical Science最新文献

Sleep duration and efficiency predict heart rate variability during work hours in intensive care unit nurses. 睡眠时间和睡眠效率预测重症监护室护士在工作时间内的心率变异性。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.194

Aoi Kono, Natsuki Nakayama, Megumi Yokoyama, Kazuya Goto, Teruhiko Suzuki, Yoshimi Moriwaki, Momoka Kataoka, Koji Tamakoshi

{"title":"Sleep duration and efficiency predict heart rate variability during work hours in intensive care unit nurses.","authors":"Aoi Kono, Natsuki Nakayama, Megumi Yokoyama, Kazuya Goto, Teruhiko Suzuki, Yoshimi Moriwaki, Momoka Kataoka, Koji Tamakoshi","doi":"10.18999/nagjms.88.2.194","DOIUrl":"10.18999/nagjms.88.2.194","url":null,"abstract":"The aim of this study was to examine the associations between components of subjective sleep quality and parasympathetic nervous activity, as assessed by heart rate variability, in intensive care unit nurses during work hours. Sleep quality was assessed using the Pittsburgh Sleep Quality Index, which comprises seven components: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medications, and daytime dysfunction. Heart rate variability was measured using a Holter monitor, with high-frequency power used as an index of parasympathetic activity. Age, energy expenditure, and step count were included as covariates. Associations between each Pittsburgh Sleep Quality Index component and both raw and adjusted high-frequency power data were analyzed using Kruskal-Wallis tests followed by Bonferroni-adjusted post hoc comparisons. Twenty-four full-time intensive care unit nurses participated. Significant differences in high-frequency adjusted for age and step count were found for sleep duration, with post hoc comparisons revealing significantly lower high-frequency in those with short sleep durations than in those with moderate sleep durations. Significant differences in both raw and all high-frequency residuals were observed for habitual sleep efficiency, with lower high-frequency power in participants with moderate sleep efficiency than in those with optimal efficiency. Poor sleep efficiency and short sleep duration were associated with reduced parasympathetic nervous activity during work hours among intensive care unit nurses.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"194-206"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of frailty on postoperative complications and resource utilization in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). 虚弱对重度主动脉瓣狭窄经导管主动脉瓣植入术（TAVI）患者术后并发症及资源利用的影响

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.274

Hiroshi Yonekura, Tasuku Fujii, Koji Kawakami, Koichi Akiyama

{"title":"The impact of frailty on postoperative complications and resource utilization in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).","authors":"Hiroshi Yonekura, Tasuku Fujii, Koji Kawakami, Koichi Akiyama","doi":"10.18999/nagjms.88.2.274","DOIUrl":"10.18999/nagjms.88.2.274","url":null,"abstract":"Patients with severe aortic stenosis undergoing transcatheter aortic valve implantation are usually older adults with multiple comorbidities and often frail. Frailty reflects increased vulnerability to adverse outcomes and is an important factor in this population; however, its impact on postoperative complications and healthcare resource utilization remains uncertain. We investigated the association between preoperative frailty and postoperative outcomes using a nationwide electronic medical records database in Japan. We included patients aged 65 years or older who underwent transcatheter aortic valve implantation between April 2013 and December 2021. Frailty was assessed with the Hospital Frailty Risk Score, with a score of 5 or higher indicating frailty. The primary outcome was acute kidney injury within seven days. Secondary outcomes included major adverse kidney events, blood transfusion within 30 days, and hospital length of stay. Among 781 patients, 237 (30.3%) were classified as frail. Acute kidney injury occurred in 8.8% of non-frail and 12.7% of frail patients. After adjustment for age, sex, comorbidities, baseline estimated glomerular filtration rate, surgical approach, anesthesia type, and hospital size, the odds ratio for acute kidney injury in frail patients was 1.42 (95% confidence interval, 0.83-2.45; P = 0.20). Hospital stay was significantly longer in frail patients, with an adjusted mean difference of 3.45 days. Preoperative frailty was not significantly associated with acute kidney injury or other complications but was associated with prolonged hospitalization. Frailty screening before transcatheter aortic valve implantation may help identify patients at risk of extended hospital stay and guide perioperative care.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"274-285"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A polymorphism in the DOCK7 gene (rs1167998) is associated with salt restriction behavior in hypertensive patients. DOCK7基因（rs1167998）多态性与高血压患者的限盐行为有关。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.217

Hideo Nakane, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Kenji Takeuchi, Yohko Nakamura, Sadao Suzuki, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Hiroaki Ikezaki, Keitaro Tanaka, Daisaku Nishimoto, Yukihide Momozawa, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai, Keitaro Matsuo

{"title":"A polymorphism in the DOCK7 gene (rs1167998) is associated with salt restriction behavior in hypertensive patients.","authors":"Hideo Nakane, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Kenji Takeuchi, Yohko Nakamura, Sadao Suzuki, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Hiroaki Ikezaki, Keitaro Tanaka, Daisaku Nishimoto, Yukihide Momozawa, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai, Keitaro Matsuo","doi":"10.18999/nagjms.88.2.217","DOIUrl":"10.18999/nagjms.88.2.217","url":null,"abstract":"Patients with hypertension are recommended to decrease their salt intake. However, some patients do not follow this recommendation. It is possible that some of these individuals cannot restrict their salt intake due to a genetic preference for salt. Thus, we attempted to identify genetic factors related to salt restriction behavior. The subjects were 817 patients with hypertension. Salt restriction status was determined by self-reported answers (yes/no) to the question \"Do you restrict your salt intake in everyday meals?\" We focused on 21 single-nucleotide polymorphisms related to genes involved in the regulation of blood pressure, salt metabolism, or neurotransmission, and analyzed the associations of the single-nucleotide polymorphisms with salt restriction behavior. Of the 817 subjects, 568 (69.5%) reported that they restricted their salt intake. Two single-nucleotide polymorphisms (rs1167998 and rs2970847) were found to be correlated with salt restriction behavior. Among the 21 single-nucleotide polymorphisms, rs1167998 in the intron region of the dedicator of cytokinesis 7 gene, which encodes a guanine nucleotide exchange factor that plays a role in axon formation and neuronal polarization, showed the strongest association (odds ratio per allele, 1.48; 95% confidence interval, 1.11 to 1.95). In conclusion, rs1167998, a single-nucleotide polymorphism in the dedicator of cytokinesis 7 gene that is associated with blood lipid levels and cardiovascular disease risk was associated with salt restriction behavior in a population of Japanese patients with hypertension. Further confirmatory studies are warranted.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"217-231"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional study of lifestyle factors related to body mass index, skeletal muscle mass, and skeletal muscle index in male Japanese workers. 日本男性工人身体质量指数、骨骼肌质量和骨骼肌指数与生活方式相关因素的横断面研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.207

Naoko Nishitani, Hisataka Sakakibara

{"title":"A cross-sectional study of lifestyle factors related to body mass index, skeletal muscle mass, and skeletal muscle index in male Japanese workers.","authors":"Naoko Nishitani, Hisataka Sakakibara","doi":"10.18999/nagjms.88.2.207","DOIUrl":"10.18999/nagjms.88.2.207","url":null,"abstract":"The study was a cross-sectional study of 377 male Japanese workers to investigate the relationship between lifestyle habits and body composition components, such as body mass index (BMI), grip strength, skeletal muscle mass, and skeletal muscle index (SMI), to promote the prevention of sarcopenic obesity and sarcopenia. Their sleep quality was evaluated using the Athens Insomnia Scale (AIS), and their exercise habits were assessed using the Japanese version of the International Physical Activity Questionnaire. Body composition components, including body fat mass and skeletal muscle mass, were measured using a body composition impedance analyzer, InBody470. Handgrip strength and SMI were evaluated based on the standard values set in the Asian Working Group for Sarcopenia 2019 (AWGS 2019) guidelines. Of the 377 participants, 119 (31.6%) had a BMI of ≥25.0 kg/m2. According to the AWGS 2019 guidelines, these participants did not meet the criteria for sarcopenic obesity. Participants with a higher BMI had higher age and handgrip strength (trend, P < 0.001). Additionally, they had higher skeletal muscle mass and SMI (trend, P < 0.001). Multiple regression analysis was performed using skeletal muscle mass and SMI as dependent variables, which revealed that skeletal muscle mass and SMI were associated with age, BMI, breakfast intake, and waist circumference. Furthermore, skeletal muscle mass was associated with heavy physical activity. From the perspective of disease prevention, our findings highlight the importance of prioritizing breakfast intake and physical activity to maintain muscle mass.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"207-216"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate and glucocorticoid use in relation to cross-sectional and longitudinal associations of red blood cell distribution width in patients with rheumatoid arthritis. 甲氨蝶呤和糖皮质激素的使用与类风湿关节炎患者红细胞分布宽度的横断面和纵向关联有关。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.339

Yoshifumi Ohashi, Mochihito Suzuki, Yasumori Sobue, Kenya Terabe, Shuji Asai, Shiro Imagama, Nobunori Takahashi

{"title":"Methotrexate and glucocorticoid use in relation to cross-sectional and longitudinal associations of red blood cell distribution width in patients with rheumatoid arthritis.","authors":"Yoshifumi Ohashi, Mochihito Suzuki, Yasumori Sobue, Kenya Terabe, Shuji Asai, Shiro Imagama, Nobunori Takahashi","doi":"10.18999/nagjms.88.2.339","DOIUrl":"10.18999/nagjms.88.2.339","url":null,"abstract":"This study investigated the clinical characteristics of red blood cell distribution width (RDW) in rheumatoid arthritis (RA) and the impact of treatment, including longitudinal dose changes. Among 691 RA patients enrolled in 2025, 591 with RDW recorded in both 2024 and 2025 were analyzed. Based on 2024 data, patients were classified into normal RDW (≤14.5%, n = 436) and high RDW (>14.5%, n = 155) groups. Logistic regression identified factors associated with high RDW. Associations with methotrexate (MTX) and glucocorticoid (GC) dose were examined, and one-year changes in RDW (ΔRDW, 2024-2025) were evaluated according to dose modifications. Patients with high RDW were older (70.6 vs 68.0 years), frequently used MTX (71.0% vs 57.6%) and GCs (41.3% vs 18.8%), had higher Disease Activity Score in 28 joints based on erythrocyte sedimentation rate (DAS28-ESR, 2.92 vs 2.68) and Health Assessment Questionnaire Disability Index (HAQ-DI, 0.64 vs 0.40), and lower hemoglobin (11.8 vs 12.9 g/dL). Multivariable analysis revealed that low hemoglobin (odds ratio [OR], 0.56), MTX use (OR, 2.47), and GC use (OR, 2.21) were independently associated with high RDW. The prevalence of high RDW increased with higher MTX (14.0%, 18.3%, 28.6%) and GC (14.0%, 20.7%, 43.2%) doses. Longitudinally, ΔRDW rose with MTX initiation or escalation (0.43 ± 0.91 vs -0.08 ± 1.06 or -0.26 ± 1.18), whereas GC changes were not significant. These findings indicate that RDW in RA is influenced more by treatment-particularly MTX use and dose escalation-than by inflammation. GC use also showed cross-sectional associations, though longitudinal effects were less evident. RDW should be interpreted in light of treatment rather than as a simple marker of disease activity.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"339-354"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IKAROS isoforms differentially control gene expression and differentiation of a B-cell acute lymphoblastic leukemia cell line. IKAROS亚型差异控制b细胞急性淋巴细胞白血病细胞系的基因表达和分化。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.232

Yuya Ogimoto, Mariko Kawachi-Nakamura, Kazunori Hashimoto, Kiyoshi Yanagisawa

{"title":"IKAROS isoforms differentially control gene expression and differentiation of a B-cell acute lymphoblastic leukemia cell line.","authors":"Yuya Ogimoto, Mariko Kawachi-Nakamura, Kazunori Hashimoto, Kiyoshi Yanagisawa","doi":"10.18999/nagjms.88.2.232","DOIUrl":"10.18999/nagjms.88.2.232","url":null,"abstract":"B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy occurring in children and a leading cause of cancer-related mortality, thus there is an urgent need for development of novel therapeutic strategies for high risk B-ALL patients. The significance of IKZF1 gene alterations in B-ALL cases is controversial, as some studies have shown those to be associated with poor prognosis, while others have reported that deletion of exons 4-7 of the IKZF1 gene, which results in generation of IKAROS isoform 6, is related favorable prognosis. For the present study, clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 was employed for knockout of the IKZF1 gene and various IKAROS knockout lines were established, which allowed for investigation of precise functions of the gene by comparing four lines with different IKAROS isoform 1 and 6 statuses. The results clearly showed induction of significant differentiation and cell cycle progression in IKAROS isoform 6 knockout clones. Furthermore, knockout of IKAROS isoform 6 resulted in significant upregulation of the expression of IKAROS isoform 1 as well as signal transducer and activator of transcription 5 (STAT5) activity, which are considered to be related to the observed features. Further investigations are warranted to provide greater mechanistic insight regarding IKAROS-mediating pathways, which will lead to development of novel therapy for human B-ALL.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"232-242"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconstruction of a chronic extensor digitorum communis tendon rupture using a bridge tendon graft. 桥式肌腱移植重建慢性指共伸肌腱断裂。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.361

Shunpei Hama, Masataka Yasuda

引用次数: 0

Enhancing nursing students' moral sensitivity through the World Cafe and ethical decision-making simulation to address diverse learning styles. 通过世界咖啡馆和伦理决策模拟，提高护生的道德敏感性，以应对不同的学习风格。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.286

Hsiao Lu Lee, Chiu-Yueh Hsiao

{"title":"Enhancing nursing students' moral sensitivity through the World Cafe and ethical decision-making simulation to address diverse learning styles.","authors":"Hsiao Lu Lee, Chiu-Yueh Hsiao","doi":"10.18999/nagjms.88.2.286","DOIUrl":"10.18999/nagjms.88.2.286","url":null,"abstract":"Teachers' instructional strategies and students' learning styles are key determinants of learning effectiveness. This study examined whether the World Cafe teaching strategy and the Four-Topic Approach to ethical decision-making could enhance outcomes in nursing ethics education. A total of 250 nursing students participated in this study. Two instructional strategies were implemented during the semester: (1) the World Cafe teaching strategy and (2) the Four-Topic Approach. Pretests and post-tests were administered. Learning-style classifications included visual (n = 106), auditory (n = 96), and kinesthetic (n = 124). Additionally, 50 students demonstrated a single learning style, 54 demonstrated two learning styles (eg, visual-auditory, auditory-kinesthetic, or kinesthetic-visual), and 56 demonstrated all three learning styles (visual, auditory, kinesthetic). Eighty-eight students could not be assigned to any learning-style category. Overall, 110 students (44%) exhibited two learning styles. Significant correlations were observed between the use of multiple teaching strategies and nursing students' learning styles (r = 0.352, p = .01), as well as between teaching strategies and moral sensitivity (r = 0.329, p = .01). Both learning styles and instructional strategies were associated with improved moral sensitivity scores. The findings suggest that integrating diverse teaching strategies - such as the World Cafe and structured ethical decision-making - can effectively enhance nursing ethics education. Tailoring instruction to accommodate students' learning styles may contribute to improved moral sensitivity among nursing students.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"286-296"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of neurotrophin-3 on bone healing in distraction osteogenesis. 神经营养因子-3对牵张成骨骨愈合的影响。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.312

Masashi Wakasugi, Masahito Fujio, Makoto Tsuboi, Qi Chang, Huiting Bian, Yuqing Liu, Hideharu Hibi

{"title":"Effect of neurotrophin-3 on bone healing in distraction osteogenesis.","authors":"Masashi Wakasugi, Masahito Fujio, Makoto Tsuboi, Qi Chang, Huiting Bian, Yuqing Liu, Hideharu Hibi","doi":"10.18999/nagjms.88.2.312","DOIUrl":"10.18999/nagjms.88.2.312","url":null,"abstract":"Distraction osteogenesis (DO) is a surgical technique used to repair skeletal defects by promoting bone and soft tissue regeneration. However, prolonged use of external fixators often causes complications such as infections and joint contractures. Neurotrophin-3 (NT-3) enhances osteoblast differentiation via bone morphogenetic protein-2 (BMP-2) and Akt signaling and may also modulate the Wnt/β-catenin pathway. In this study, we investigated the role of NT-3 in bone regeneration during DO. A DO model was established in 9-week-old male ICR mice, in which tibiae were osteotomized and stabilized with external fixators under anesthesia. After a 5-day latency period, distraction was performed at 0.2 mm every 12 hours for 8 days. RNA was extracted at defined time points post-osteotomy for quantitative polymerase chain reaction (qPCR) analysis, and NT-3 was administered post-distraction. Bone regeneration was evaluated by radiographic, histological, and biomechanical analyses. The effects of NT-3 and Dickkopf-1 were further examined in ST2 bone marrow-derived mesenchymal stem cells. NT-3 significantly enhanced bone formation, increased bone mineral density within the DO gap, and improved the mechanical stiffness of regenerated bone. Histological examination revealed earlier bone continuity and greater callus formation in the NT-3 group. Gene expression analysis demonstrated upregulation of Wnt/β-catenin pathway components, including Wnt10b, β-catenin, and low-density lipoprotein receptor-related protein 5 (LRP5). In ST2 cells, NT3 increased the expression of LRP5, LRP6, β-catenin, and Runx2, while cotreatment with Dickkopf1 abolished these effects. These findings suggest that NT-3 promotes bone regeneration during DO by activating the Wnt/β-catenin signaling pathway, highlighting its therapeutic potential to improve DO outcomes.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"312-325"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of pharmacist-led management of candidemia in a tertiary care hospital without a full-time infectious disease specialist. 在没有专职传染病专家的三级保健医院，药剂师主导的念珠菌病管理的有效性。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-05-01 DOI: 10.18999/nagjms.88.2.243

Teruhisa Kinoshita, Shoko Sahara, Atsuya Kondo, Yuki Kondo, Yoichi Ishitsuka, Norio Takimoto, Keisuke Oka

{"title":"Effectiveness of pharmacist-led management of candidemia in a tertiary care hospital without a full-time infectious disease specialist.","authors":"Teruhisa Kinoshita, Shoko Sahara, Atsuya Kondo, Yuki Kondo, Yoichi Ishitsuka, Norio Takimoto, Keisuke Oka","doi":"10.18999/nagjms.88.2.243","DOIUrl":"10.18999/nagjms.88.2.243","url":null,"abstract":"There are limited reports on the effectiveness of promoting pharmacist-led management of candidemia in tertiary care hospitals without a full-time infectious disease specialist. We aimed to assess the effectiveness of promoting pharmacist-led management of candidemia in a tertiary care hospital without a full-time infectious disease specialist and to determine the type of support provided by pharmacists in the antimicrobial stewardship team. This retrospective cohort study evaluated patients with Candida spp. detected in blood cultures between April 2013 and March 2024 at our hospital. To compare the effect of bundled intervention on patients with candidemia, patients enrolled during the periods from April 2013 to March 2018 and April 2018 to March 2024 were classified in the pre- and post-antimicrobial stewardship team pharmacist intervention groups, respectively. There were no significant differences in the baseline clinical characteristics or Candida spp. distribution between the two groups. Compliance to the candidemia treatment bundle significantly improved in the post-antimicrobial stewardship team pharmacist intervention group (4.5% vs 39.6%); however, there was no difference between the two groups in 30-day mortality. The antimicrobial stewardship team pharmacist primarily contributed by recommending treatment initiation, drug selection, and checking for bundle compliance. Pharmacist-led management of candidemia did not improve outcomes for patients with candidemia in a tertiary care hospital with no full-time infectious disease specialist. However, this management may have helped improve the quality of antifungal therapy in terms of drug selection, dosing, and drug interactions, thus contributing to improved candidemia treatment bundle compliance.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 2","pages":"243-257"},"PeriodicalIF":0.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0