Nagoya Journal of Medical Science最新文献_第6页

Number and mortality of aortic surgery in Japan. 日本主动脉手术的数量和死亡率。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-11-01 DOI: 10.18999/nagjms.86.4.538

Akihiko Usui, Rena Usui, Shunsuke Nakata

{"title":"Number and mortality of aortic surgery in Japan.","authors":"Akihiko Usui, Rena Usui, Shunsuke Nakata","doi":"10.18999/nagjms.86.4.538","DOIUrl":"10.18999/nagjms.86.4.538","url":null,"abstract":"According to the Japanese Association for Thoracic Surgery annual surgery survey, the number of aortic surgery has been increasing constantly in the last two decades, with the rates approximately doubling in each decade (5,167, 11,956, and 22,708 cases in 1999, 2009, and 2019, respectively). In 2019, aortic surgery was performed for 11,036 (49%) nondissecting unruptured aneurysm, 730 (3%) ruptured aneurysm, 6,351 (28%) acute type A aortic dissection, 1,412 (6%) chronic type A aortic dissection, 2,385 (11%) acute type B aortic dissection, and 703 (3%) chronic type B aortic dissection cases. The outcomes have been improving annually. From 1999 to 2019, the hospital mortality rates decreased significantly in each case: nondissecting unruptured aneurysm, 9.8% to 4.2%; ruptured aneurysm, 38.5% to 19.7%; acute type A aortic dissection, 18.7% to 10.4%; chronic type A aortic dissection, 7.2% to 4.5%; acute type B aortic dissection, 25.2% to 9.8%; and chronic type B aortic dissection, 7.5% to 3.4%. Furthermore, stent graft, a new technology developed in 1990, was performed in 35%, 53%, 1%, 21%, 62%, and 75% of cases mentioned above, respectively, in 2019. The widespread use of stent graft greatly contributed to the increased number of aortic surgeries and improvement of surgical outcomes.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 4","pages":"538-548"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of endovascular coil embolization for unruptured middle cerebral artery aneurysms: middle-term clinical and imaging outcomes with 3 years mean follow-up periods, a 16-year experience. 血管内线圈栓塞治疗未破裂的大脑中动脉瘤的疗效和安全性：平均随访3年的中期临床和影像学结果，有16年的经验。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-11-01 DOI: 10.18999/nagjms.86.4.596

Taketo Hanyu, Takashi Izumi, Takafumi Tanei, Masahiro Nishihori, Shunsaku Goto, Yoshio Araki, Kinya Yokoyama, Shigeru Miyachi, Ryuta Saito

{"title":"Efficacy and safety of endovascular coil embolization for unruptured middle cerebral artery aneurysms: middle-term clinical and imaging outcomes with 3 years mean follow-up periods, a 16-year experience.","authors":"Taketo Hanyu, Takashi Izumi, Takafumi Tanei, Masahiro Nishihori, Shunsaku Goto, Yoshio Araki, Kinya Yokoyama, Shigeru Miyachi, Ryuta Saito","doi":"10.18999/nagjms.86.4.596","DOIUrl":"https://doi.org/10.18999/nagjms.86.4.596","url":null,"abstract":"The anatomical characteristics of middle cerebral artery aneurysms make endovascular treatment difficult. This study evaluated the efficacy and safety of endovascular treatment of unruptured middle cerebral artery aneurysm in preventing rupture. A retrospective review of patients who underwent coil embolization for unruptured middle cerebral artery aneurysm between 2006 and 2022 at Nagoya University Hospital with at least 12 months followed up was conducted. Imaging and clinical outcomes were described using the Raymond classification and the modified Rankin Scale, respectively. Good imaging outcome was defined as complete occlusion or neck remnant and clinical outcome as modified Rankin Scale score of 0-2. Patients were divided into initial and recurrent group based on the number of treatments, pre- and post-stent groups based on when stents became available in Japan. A total of 77 patients (80 with aneurysms) were included in the final analysis. Their average age was 60.3 years, and their average follow-up period was 38 months. Favorable clinical outcomes were achieved for 96.2% among 66 (97.0%) initial and 11 (91.7%) recurrent aneurysms. Furthermore, good imaging outcomes were obtained in 90.0 %, and 5% had permanent symptomatic ischemic complications. The pre-stent group had a significantly higher proportion of patients with narrow-neck aneurysms than the post-stent group. There were no significant differences in terms of imaging and clinical outcomes or complication rates. The present study demonstrated that endovascular treatment of unruptured middle cerebral artery aneurysm was safe and effective in preventing rupture. The wide-neck aneurysm was also well embolized by using adjunctive technique.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 4","pages":"596-607"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium marinum infection successfully treated with oral administration of minocycline and thermotherapy. 海洋分枝杆菌感染成功地治疗口服米诺环素和热疗法。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-11-01 DOI: 10.18999/nagjms.86.4.699

Yuka Morita, Kana Tanahashi, Chiaki Terashima-Murase, Ryo Fukaura, Keisuke Oka, Tetsuya Yagi, Yuji Miyamoto, Manabu Ato, Norihisa Ishii, Masashi Akiyama

{"title":"Mycobacterium marinum infection successfully treated with oral administration of minocycline and thermotherapy.","authors":"Yuka Morita, Kana Tanahashi, Chiaki Terashima-Murase, Ryo Fukaura, Keisuke Oka, Tetsuya Yagi, Yuji Miyamoto, Manabu Ato, Norihisa Ishii, Masashi Akiyama","doi":"10.18999/nagjms.86.4.699","DOIUrl":"10.18999/nagjms.86.4.699","url":null,"abstract":"We report a case of a woman presenting with an erythematous finger nodule, with a history of exposure to tropical fish. The erythematous nodules subsequently spread proximally from the finger. Initial treatment with oral amoxicillin-clavulanate was unsuccessful, and she developed a drug eruption. Treatment with oral minocycline and thermotherapy was initiated, as we suspected infection with Mycobacterium marinum (M. marinum) from her history and clinical features. A culture from a skin biopsy from the finger grew M. marinum, confirming the diagnosis. There is no established treatment regimen for skin infections caused by M. marinum. In this case, it took time for cultures to confirm the diagnosis of non-tuberculous mycobacterial infection. While it would be ideal to await culture results, we felt it was better for the patient to initiate treatment, and in M. marinum infections, minocycline is considered particularly effective. However, it was envisaged that this would result in a prolonged treatment course, leading to potential resistance. Thermotherapy was added in an attempt to shorten the treatment period. This regime was successful, and the patient has remained free of recurrence since. The early initiation of treatment for cutaneous non-tuberculous mycobacterial infection requires aggressive suspicion. Also, testing, including adequate sampling and culturing, is essential for an accurate diagnosis. Slow-growing mycobacteria may take several months to be definitively diagnosed, as they grow only under certain conditions. Therefore, thorough clinical history-taking and information sharing with the microbiology team are essential. Our case illustrates this, and we believe this has important educational value.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 4","pages":"699-702"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of vasopressin use for postoperative atrial fibrillation in off-pump coronary artery bypass grafting. 血管加压素对非体外循环冠状动脉搭桥术术后房颤的影响。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-11-01 DOI: 10.18999/nagjms.86.4.645

Kochi Yamane, Tasuku Fujii, Tadashi Aoyama, Mikio Nonogaki, Kimitoshi Nishiwaki

{"title":"Impact of vasopressin use for postoperative atrial fibrillation in off-pump coronary artery bypass grafting.","authors":"Kochi Yamane, Tasuku Fujii, Tadashi Aoyama, Mikio Nonogaki, Kimitoshi Nishiwaki","doi":"10.18999/nagjms.86.4.645","DOIUrl":"10.18999/nagjms.86.4.645","url":null,"abstract":"Postoperative atrial fibrillation complicates 15-40% of cardiac surgery cases and is associated with various adverse health outcomes including high mortality. Although vasopressin administration decreases postoperative atrial fibrillation in on-pump coronary artery bypass grafting, its use in off-pump coronary artery bypass grafting has not been investigated. Therefore, we evaluated the effect of vasopressin use in off-pump coronary artery bypass grafting. For this retrospective, observational study at a single-center community hospital in Yokkaichi, Japan, 298 patients who had undergone elective or emergency off-pump coronary artery bypass grafting between April 2015 and March 2021 were enrolled. Participants were divided into two groups: vasopressin and non-vasopressin groups. The outcomes in both groups were analyzed after propensity score matching, which revealed 40 patients in each matched group. Patients with chronic atrial fibrillation and those who were converted from off-pump to on-pump surgery were excluded. The primary outcome was postoperative atrial fibrillation occurrence within 4 days post-surgery. Secondary outcomes were 30-day mortality, intensive care unit and hospital stays, and postoperative complications (acute kidney injury, stroke, acute myocardial infarction, and respiratory complications). Although 11 patients (27.5%) in the vasopressin group were affected by postoperative atrial fibrillation when compared to 18 (45%) patients in the non-vasopressin groups, the difference was not significant (P=0.163). Similarly, no significant differences were observed in the secondary outcomes between groups. In off-pump coronary artery bypass grafting, vasopressin use may contribute to reduced postoperative atrial fibrillation; however, a large prospective study needs to be conducted for confirmation.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 4","pages":"645-654"},"PeriodicalIF":0.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study. 一项前瞻性研究：基线甲状腺自身抗体可预测接受抗程序性细胞死亡-1阻断剂治疗的非小细胞肺癌患者生存期的延长。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.452

Takayuki Okuji, Shintaro Iwama, Tomoko Kobayashi, Yoshinori Yasuda, Masaaki Ito, Ayana Yamagami, Masahiko Ando, Tetsunari Hase, Hirofumi Shibata, Takahiro Hatta, Xin Zhou, Takeshi Onoue, Yohei Kawaguchi, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Yuichi Ando, Naozumi Hashimoto, Hiroshi Arima

{"title":"Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study.","authors":"Takayuki Okuji, Shintaro Iwama, Tomoko Kobayashi, Yoshinori Yasuda, Masaaki Ito, Ayana Yamagami, Masahiko Ando, Tetsunari Hase, Hirofumi Shibata, Takahiro Hatta, Xin Zhou, Takeshi Onoue, Yohei Kawaguchi, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Yuichi Ando, Naozumi Hashimoto, Hiroshi Arima","doi":"10.18999/nagjms.86.3.452","DOIUrl":"10.18999/nagjms.86.3.452","url":null,"abstract":"The presence of anti-thyroid antibodies (ATAs) is a biomarker for the development of thyroid dysfunction induced by anti-programmed cell death-1 antibodies (PD-1-Abs). While patients with thyroid dysfunction reportedly showed better overall survival (OS), it remains unknown if ATAs at baseline can predict OS. Therefore, in this study, we examined the association of ATAs at baseline with OS in non-small cell lung cancer (NSCLC) patients with different levels of programmed cell death-1 ligand 1 (PD-L1) positivity associated with PD-1-Ab treatment efficacy. A total of 81 NSCLC patients treated with PD-1-Abs were evaluated for ATAs at baseline and prospectively for OS. Among the 81 patients, 49 and 32 patients had ≥50% (group A) and <50% (group B) PD-L1 positivity, respectively. Median OS did not differ significantly between patients with (n = 13) and without (n = 36) ATAs at baseline in group A. In contrast, median OS was significantly longer in patients with (n = 10) versus without (n = 22) ATAs at baseline in group B (not reached vs 378 days, respectively; 95% CI, 182 to 574 days, p = 0.049). These findings suggest that the presence of ATAs at baseline is a biomarker to predict better treatment efficacy of PD-1-Abs in NSCLC patients with low PD-L1 positivity, while the difference in OS in those with high PD-L1 positivity may be masked by increased tumor expression of PD-L1.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"452-463"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of onset of intraoperative transfusion anaphylaxis: a literature review. 术中输血过敏性休克的发病时间：文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.351

Yasuhiro Amano, Tasuku Fujii, Takahiro Tamura, Takahiro Hirai, Kimitoshi Nishiwaki

{"title":"Timing of onset of intraoperative transfusion anaphylaxis: a literature review.","authors":"Yasuhiro Amano, Tasuku Fujii, Takahiro Tamura, Takahiro Hirai, Kimitoshi Nishiwaki","doi":"10.18999/nagjms.86.3.351","DOIUrl":"10.18999/nagjms.86.3.351","url":null,"abstract":"Clinical diagnosis of intraoperative transfusion anaphylaxis using clinical symptoms is challenging and should be made carefully, as an incorrect clinical diagnosis can exacerbate surgical bleeding secondary to stopping a clinically indicated blood transfusion. The timing of onset of anaphylaxis to start of transfusion may be the key to correctly diagnosing intraoperative transfusion anaphylaxis clinically. However, the reliability of this measure remains unknown. A literature search was conducted using MEDLINE, Embase, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials up to June 29, 2021. No language restriction was applied. Two pairs of review authors independently reviewed intraoperative transfusion anaphylaxis cases and extracted data on the timing of onset of anaphylaxis to start of transfusion. A total of 8,918 articles were reviewed, the full texts of 186 articles were assessed, and 20 intraoperative transfusion anaphylaxis cases were included in this study. The 20 intraoperative transfusion anaphylaxis cases included a precise timing of onset. With nine cases, cardiovascular surgery was the most prevalent, and one case was fatal. Fifteen cases had a timing of onset in minutes, and of those, 14 reported timeframes within 30 minutes of initiation of transfusion (median: 15.5, 5-30 minutes). Almost all cases of intraoperative transfusion anaphylaxis occurred within 30 minutes of the transfusion initiation. This timeframe may be helpful in the clinical diagnosis of intraoperative transfusion anaphylaxis.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"351-360"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous regression of lumbar disc herniation: four cases report and review of the literature. 腰椎间盘突出症的自然消退：四例报告和文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.370

Yang Zheng, Can Zhu, Jie-Feng Huang, Advaith Manoharasetty, Hong Zhang

引用次数: 0

Longitudinal analysis of body dissatisfaction: the desire to be thinner among women in Japan during low-risk pregnancies. 身体不满意度的纵向分析：日本低危妊娠妇女希望变瘦的愿望。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.422

Sayaka Tsuchiya, Masayuki Endo, Kazutomo Ohashi

{"title":"Longitudinal analysis of body dissatisfaction: the desire to be thinner among women in Japan during low-risk pregnancies.","authors":"Sayaka Tsuchiya, Masayuki Endo, Kazutomo Ohashi","doi":"10.18999/nagjms.86.3.422","DOIUrl":"10.18999/nagjms.86.3.422","url":null,"abstract":"Body dissatisfaction during pregnancy can significantly impact maternal and child health. Therefore, this longitudinal study investigated changes in body dissatisfaction using two figure rating scales developed from photographic digital data of Japanese pregnant women during the sixth and tenth months of pregnancy. Study participants were recruited at their sixth month prenatal visit at a primary maternity clinic in Japan from October 2014 to March 2015. Body dissatisfaction was estimated based on the perceived and ideal body sizes of 135 pregnant women, expressed as body mass index. Data were collected using self-administered questionnaires. The study found that body dissatisfaction in the tenth month was significantly higher than that in the sixth month. Among the participants, 75 (55.6%) and 79 (58.5%) experienced body dissatisfaction, desiring to be thinner (where perceived body size exceeded ideal body size) during the sixth and tenth months of pregnancy, respectively. Pregnant women who had body dissatisfaction and a desire to be thinner in the sixth month tended to experience an increase in body dissatisfaction by the tenth month compared to those without body dissatisfaction in the sixth month. During the sixth and tenth months, women with body dissatisfaction showed significantly larger perceived body sizes than those without body dissatisfaction. These results indicated that the use of a figure rating scale at the sixth month of pregnancy may help identify women with body dissatisfaction; moreover, perceived body size might be a key factor in preventing an increase in body dissatisfaction from the second to third trimesters.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"422-434"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells. 神经节苷脂GD3/GD2阳性胶质瘤细胞分泌的外泌体在增强GD3/GD2阴性胶质瘤细胞的恶性表型和信号方面发挥关键作用。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.435

Mohammad Abul Hasnat, Yuhsuke Ohmi, Farhana Yesmin, Mariko Kambe, Yoshiyuki Kawamoto, Robiul H Bhuiyan, Momoka Mizutani, Noboru Hashimoto, Akiko Tsuchida, Yuki Ohkawa, Kei Kaneko, Orie Tajima, Keiko Furukawa, Koichi Furukawa

{"title":"Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells.","authors":"Mohammad Abul Hasnat, Yuhsuke Ohmi, Farhana Yesmin, Mariko Kambe, Yoshiyuki Kawamoto, Robiul H Bhuiyan, Momoka Mizutani, Noboru Hashimoto, Akiko Tsuchida, Yuki Ohkawa, Kei Kaneko, Orie Tajima, Keiko Furukawa, Koichi Furukawa","doi":"10.18999/nagjms.86.3.435","DOIUrl":"10.18999/nagjms.86.3.435","url":null,"abstract":"Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers. Recently, we reported that human gliomas expressing GD3/GD2 exhibited enhanced malignant phenotypes. Here, we investigated the function of GD3/GD2 in glioma cells and GD3/GD2-expressing glioma-derived exosomes. As reported previously, transfectant cells of human glioma U251 MG expressing GD3/GD2 showed enhanced cancer phenotypes compared with GD3/GD2-negative controls. When GD3/GD2-negative cells were treated with exosomes secreted from GD3/GD2-positive cells, clearly increased malignant properties were observed. Furthermore, increased phosphorylation of signaling molecules was detected after 5-15 min of exosome treatment, ie, higher tyrosine phosphorylation of platelet-derived growth factor receptor, focal adhesion kinase, and paxillin was found in treated cells than in controls. Phosphorylation of extracellular signal-regulated kinase-1/2 was also enhanced. Consequently, it is suggested that exosomes secreted from GD3/GD2-positive gliomas play important roles in enhancement of the malignant properties of glioma cells, leading to total aggravation of heterogenous cancer tissues, and also in the regulation of tumor microenvironments.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"435-451"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis. 韦多珠单抗对溃疡性结肠炎患者疗效的预测因素。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.407

Go Kajikawa, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Kota Uetsuki, Takashi Hirose, Tadashi Iida, Yasuyuki Mizutani, Kentaro Yamao, Takuya Ishikawa, Kazuhiro Furukawa, Hiroki Kawashima

{"title":"Predictors of the efficacy of vedolizumab in patients with ulcerative colitis.","authors":"Go Kajikawa, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Kota Uetsuki, Takashi Hirose, Tadashi Iida, Yasuyuki Mizutani, Kentaro Yamao, Takuya Ishikawa, Kazuhiro Furukawa, Hiroki Kawashima","doi":"10.18999/nagjms.86.3.407","DOIUrl":"10.18999/nagjms.86.3.407","url":null,"abstract":"Vedolizumab is a treatment option for ulcerative colitis but data on predictors of treatment response remain insufficient to establish personalized treatment strategies. We aimed to investigate the real-world effectiveness of vedolizumab in adult patients with ulcerative colitis and explore factors involved in predicting treatment response. This single-center, single-arm, prospective observational study included 26 patients with clinically active ulcerative colitis patients' characteristics at baseline, epidemiological information, existing treatment, clinical activity index score, endoscopic score, and blood test data were collected. Serum levels of tumor necrosis factors alpha, interferon gamma, interleukin-4, interleukin-6, interleukin-10, interleukin-17, soluble mucosal addressin cell adhesion molecule 1, and soluble vascular cell adhesion molecule 1 were measured. Patient characteristics in the remission and non-remission groups were compared based on these parameters. Clinical remission at 6 weeks of treatment occurred in 9 (35%) of the 26 patients. At 14 weeks, clinical remission was observed in 11 patients (42%). There were no significant differences pertaining to age, sex, duration of disease, extent of disease, steroid resistance, or prior treatment with biological agents among the two groups after 14 weeks of treatment. Hemoglobin ≥ 11.5 g/dL (odds ratio, 15.0; 95% confidence interval, 1.50-149; P=0.014) and soluble mucosal addressin cell adhesion molecule 1 ≥ 765 pg/mL (odds ratio, 17.3; 95% confidence interval, 2.36-127; P=0.004) were significant factors. In conclusion, hemoglobin and serum soluble mucosal addressin cell adhesion molecule 1 levels are factors correlated with the therapeutic efficacy of vedolizumab.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"407-421"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0