Nagoya Journal of Medical Science最新文献_第6页

Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established. 从原发性血小板增多症到急性髓性白血病的克隆进化过程，CALR 突变的 Marimo 细胞系就是从该患者身上建立起来的。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.326

Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi

{"title":"Clonal evolution process from essential thrombocythemia to acute myeloid leukemia in the original patient from whom the CALR-mutated Marimo cell line was established.","authors":"Yoko Ushijima, Yuichi Ishikawa, Takahiro Nishiyama, Naomi Kawashima, Takashi Kanamori, Masashi Sanada, Hitoshi Kiyoi","doi":"10.18999/nagjms.86.2.326","DOIUrl":"10.18999/nagjms.86.2.326","url":null,"abstract":"We previously reported the Marimo cell line, which was established from the bone marrow cells of a patient with essential thrombocythemia (ET) at the last stage after transformation to acute myeloid leukemia (AML). This cell line is widely used for the biological analysis of ET because it harbors CALR mutation. However, genetic processes during disease progression in the original patient were not analyzed. We sequentially analyzed the genetic status in the original patient samples during disease progression. The ET clone had already acquired CALR and MPL mutations, and TP53 and NRAS mutations affected the disease progression from ET to AML in this patient. Particularly, the variant allele frequency of the NRAS mutation increased along with the disease progression after transformation, and the NRAS-mutated clone selectively proliferated in vitro, resulting in the establishment of the Marimo cell line. Although CALR and MPL mutations co-existed, MPL was not expressed in Marimo cells or any clinical samples. Furthermore, mitogen-activated protein kinase (MAPK) but not the JAK2-STAT pathway was activated. These results collectively indicate that MAPK activation is mainly associated with the proliferation ability of Marimo cells.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"326-332"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors for nausea and vomiting requiring the daily administration of 5-HT₃ receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma. 放疗联合替莫唑胺治疗高级别胶质瘤时，需要每天服用 5-HT3 受体拮抗剂的恶心和呕吐风险因素。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.304

Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada

{"title":"Risk factors for nausea and vomiting requiring the daily administration of 5-HT3 receptor antagonists in radiotherapy combined with temozolomide for high-grade glioma.","authors":"Mai Takagi, Atsunobu Sagara, Yasuo Kumakura, Minako Watanabe, Rikako Inoue, Masayuki Miyazaki, Fumiharu Ohka, Kazuya Motomura, Atsushi Natsume, Toshihiko Wakabayashi, Ryuta Saito, Kiyofumi Yamada","doi":"10.18999/nagjms.86.2.304","DOIUrl":"10.18999/nagjms.86.2.304","url":null,"abstract":"Radiotherapy combined with temozolomide (TMZ+RT) is the primary treatment for high-grade glioma. TMZ is classified as a moderate emetic risk agent and, thus, supportive care for nausea and vomiting is important. In Nagoya University Hospital, all patients are treated with a 5-hydroxy-tryptamine 3 receptor antagonist (5-HT3RA) for the first 3 days. The daily administration of 5-HT3RA is resumed after the 4th day based on the condition of patients during TMZ+RT. Therefore, the present study investigated risk factors for nausea and vomiting in patients requiring the daily administration of 5-HT3RA. Patients with high-grade glioma who received TMZ+RT between January 2014 and December 2019 at our hospital were included. Patients were divided into two groups: a control group (patients who did not resume 5-HT3RA) and resuming 5-HT3RA group (patients who resumed 5-HT3RA after the 4th day), and both groups were compared to identify risk factors for nausea and vomiting during TMZ+RT. There were 78 patients in the control group (68%) and 36 in the resuming 5-HT3RA group (32%). A multivariate analysis of patient backgrounds in the two groups identified age <18 years, PS 2 or more, and occipital lobe tumors as risk factors for nausea and vomiting. Nausea and vomiting were attenuated in 30 patients (83%) in the resuming 5-HT3RA group following the resumption of 5-HT3RA. The results obtained highlight the importance of extracting patients with these risk factors before the initiation of therapy and the early resumption or daily administration of 5-HT3RA according to the condition of each patient.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"304-313"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care. 切实可行的体重管理，最大限度地减少妊娠并发症，促进妇女健康：孕期保健的可能性。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.160

Tomomi Kotani, Sho Tano, Takafumi Ushida, Kenji Imai, Hiroaki Kajiyama

{"title":"Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care.","authors":"Tomomi Kotani, Sho Tano, Takafumi Ushida, Kenji Imai, Hiroaki Kajiyama","doi":"10.18999/nagjms.86.2.160","DOIUrl":"10.18999/nagjms.86.2.160","url":null,"abstract":"Pregnancy is an excellent opportunity to provide medical interventions to women. It is also a stress test used to predict health. Numerous studies have demonstrated that the pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) are critical factors for pregnancy complications such as hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), large or small gestational age infants, and spontaneous preterm birth (sPTB). These complications are associated with an increased risk of cardiovascular disease (CVD), which is a leading cause of mortality in women. In addition, complications adversely affect the short- and long-term prognoses of children. Optimal GWG to reduce complications is recommended based on pre-pregnancy BMI; however, racial differences should also be noted. The values in the Japanese guidelines are lower than those in the American Institute of Medicine guidelines. The Asian BMI thresholds for CVD risk are also lower than those in Europe. Therefore, weight management should be based on racial/genetic background. Interpregnancy weight gain or loss has also been reported to be associated with the risk of pregnancy complications; however, few studies have been conducted in Asian populations. Our previous reports suggested that avoiding an excess of 0.6 kg/m2/year of annual BMI gain may reduce the risk of HDP or GDM, and insufficient gain of < 0.25 kg/m2/year may increase sPTB recurrence. Annual BMI is useful for practical weight control during interpregnancy. Based on these findings, effective approaches should be established to improve the health of women and their offspring.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"160-168"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study. 社区居民患者的运动综合征与通过皮肤自发荧光测量的高级糖化终产物之间的关系：Yakumo 研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-05-01 DOI: 10.18999/nagjms.86.2.314

Yuto Ozawa, Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Hiroki Iida, Masanori Okamoto, Hiroaki Nakashima, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama

{"title":"Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study.","authors":"Yuto Ozawa, Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Hiroki Iida, Masanori Okamoto, Hiroaki Nakashima, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama","doi":"10.18999/nagjms.86.2.314","DOIUrl":"10.18999/nagjms.86.2.314","url":null,"abstract":"Advanced glycation end products (AGEs) have been reported to be associated with osteoporosis, aging, sarcopenia, and frailty. This study aimed to investigate the association AGEs with locomotive syndrome (LS). Participants were Japanese individuals aged 39 years or older who participated in the Yakumo Study (n=230). AGEs were measured by skin autofluorescence (SAF) using an AGE reader. We investigated SAF values for each locomotive stage. Multivariate logistic regression models were used to calculate the odds ratios of LS-associated factors. The relationships between SAF and physical performance and bone mineral density (BMD) were investigated. A receiver operating characteristic (ROC) curves were generated to determine the optimal cut-off value of SAF for predicting LS. SAF values tended to increase correspondingly with LS severity. SAF was an independently explanatory factor for LS (odds ratio 2.70; 95% confidence interval [CI] 1.040-6.990). SAF was positively correlated with the 10-m walking speed, The Timed Up and Go test results, and was negatively correlated with BMD. ROC curve represented by SAF for the presence or absence of LS risk had an area under the curve of 0.648 (95% CI: 0.571-0.726). High SAF values were identified as an independent risk factor for LS. AGEs could be a potential screening tool for people for LS.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 2","pages":"314-325"},"PeriodicalIF":0.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11219223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between exercise habits and physical function in children aged 9-12 years. 9-12 岁儿童的运动习惯与身体机能之间的关系。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.24

Daiki Takahashi, Tadashi Ito, Yuji Ito, Kentaro Natsume, Koji Noritake, Nobuhiko Ochi, Hideshi Sugiura

{"title":"Relationship between exercise habits and physical function in children aged 9-12 years.","authors":"Daiki Takahashi, Tadashi Ito, Yuji Ito, Kentaro Natsume, Koji Noritake, Nobuhiko Ochi, Hideshi Sugiura","doi":"10.18999/nagjms.86.1.24","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.24","url":null,"abstract":"Exercise improves physical health and positively impacts physical functions in children. Additionally, the habitual exercise established during childhood often continues into adulthood. Therefore, childhood is an important period for establishing healthy habits. Investigating the relationship between the presence or absence of daily exercise and physical functions may provide important information to confirm poor physical function in children with poor exercise habits. Therefore, this study examined the relationship between exercise habits as defined by the Japanese Ministry of Health, Labor, and Welfare and physical function in children aged 9-12 years. Approximately 239 children were included in this study. Participants answered a questionnaire about their exercise habits. We evaluated the skeletal muscle mass index, grip strength, standing broad jump, one-leg standing time, and gait deviation index. Logistic regression analyses were performed to assess exercise habit association with skeletal muscle mass index, physical function, and gait deviation index after adjusting for sex. Of the 239 children, 75.5% (n = 178) had exercise habits. A significant association was noted between exercise habits and skeletal muscle mass index and standing broad jump (skeletal muscle mass index: OR, 1.84; 95% CI, 1.01-3.36 and p<0.05; standing long jump: OR, 1.02; 95% CI, 1.00-1.04 and p<0.05). In conclusion, exercise regardless of exercise level for at least 30 min per day, 2 days per week, for at least 1 year is important for skeletal muscle mass and instantaneous lower limb muscular strength development in school-aged children.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"24-35"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seven-year follow-up of endovascular treatment of iatrogenic brachioradial artery injury complicating percutaneous coronary intervention: a case report. 经皮冠状动脉介入治疗并发先天性肱动脉损伤的血管内治疗七年随访：病例报告。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.155

Hyeon Wook Kim, Sung Soo Kim, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, Dong Hyun Choi

{"title":"Seven-year follow-up of endovascular treatment of iatrogenic brachioradial artery injury complicating percutaneous coronary intervention: a case report.","authors":"Hyeon Wook Kim, Sung Soo Kim, Hyun Kuk Kim, Young Jae Ki, Keun Ho Park, Dong Hyun Choi","doi":"10.18999/nagjms.86.1.155","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.155","url":null,"abstract":"The radial artery has been used increasingly for percutaneous coronary intervention because of its safety and feasible access route. Nevertheless, transradial complications are possible because of the variation in radial artery anatomy. We experienced a case of the brachioradial artery injury secondary to catheterization, presenting as hypovolemic shock. A 76-year-old woman presented at our emergency department complaining of effort-induced angina. Coronary angiography via the right radial artery showed critical stenosis in the middle of the left anterior descending coronary artery. After wiring into this vessel, balloon angioplasty using a 6-Fr Judkin left guiding catheter was performed with the deployment of the zotarolimus-eluting stent. There was difficulty in negotiating the guidewire and balloons in that resistance was experienced while passing the catheter in the upper arm. Therefore, retrograde radial arteriography was performed to determine any injury to radial artery. This showed contrast extravasation in the brachioradial artery. Initially, manual compression was tried. However, 2 hours later, the patient developed cold sweating and went into a stupor. Laboratory findings showed a decline in hemoglobin, leading to suspicion of hemorrhagic shock. We applied over 30 minutes of balloon inflation, but this was ineffective. While surgical repair was not available, a 6.0 × 50 mm Viabahn stent was placed over the axillary artery. Subsequent angiography showed no further leakage or occlusion of the brachioradial artery. The postprocedural period was uneventful, and the patient was discharged with dual antiplatelet agents. At a 7-year clinical follow-up, the patient was free from limb ischemia symptoms.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"155-159"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The usefulness of shear wave elastography in evaluating erectile dysfunction severity before and after prostaglandin E1 test. 剪切波弹性成像技术在前列腺素 E1 测试前后评估勃起功能障碍严重程度的实用性。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.104

Fumitoshi Sakamoto, Seiji Matsumoto, Toshikazu Otani, Yasuharu Takagi, Tokunori Yamamoto

{"title":"The usefulness of shear wave elastography in evaluating erectile dysfunction severity before and after prostaglandin E1 test.","authors":"Fumitoshi Sakamoto, Seiji Matsumoto, Toshikazu Otani, Yasuharu Takagi, Tokunori Yamamoto","doi":"10.18999/nagjms.86.1.104","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.104","url":null,"abstract":"Prostaglandin E1 intracavernous injection test is an established method for diagnosing erectile dysfunction. However, the evaluation is non-objective and often influenced by the evaluator's subjectivity. Herein, we measured and objectively evaluated shear wave elastography results of the corpus cavernosum before and after injection in 16 patients who underwent prostaglandin E1 testing. The response score of prostaglandin E1 tests were \"1\" in 2 cases, \"2\" in 2 cases, and \"3\" in 12 cases. The average transmission velocity before the injection and at the time of maximum erection after the injection were 2.21 m/s and 1.57 m/s, respectively. Transmission velocity decreased during erection in 14 of 16 cases (87.5%). The overall rate of change in transmission velocity due to injection was -26.7% and was significantly different between the poor (responses 1 and 2: -16.1%) and good erection (response 3: -30.2%) groups. To the best of our knowledge, this is the first attempt to evaluate erectile phenomenon using percutaneous ultrasonic elastography in Japan. Rate of change in shear wave transmission velocity due to prostaglandin E1 injection in the corpus cavernosum penis was associated with the degree of erection. Therefore, the rate of change in shear wave transmission velocity in the corpus cavernosum penis could be used as an objective index of erectile phenomenon. Percutaneous ultrasonic elastography is a non-invasive and useful test method for diagnosing erectile dysfunction, determining the therapeutic effect, and predicting prognosis.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"104-109"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

＜Editors' Choice＞ The relationship between preoperative foot alignment and postoperative outcomes in patients who underwent initial total knee arthroplasty. ＜编辑推荐＞初次接受全膝关节置换术的患者术前足部对位与术后效果的关系。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.91

Aika Hishida, Hideki Hiraiwa, Izumi Kadono, Hidetoshi Yamaguchi, Takashi Okada, Chiaki Terai, Azusa Kayamoto, Yoshihiro Nishida

{"title":"＜Editors' Choice＞ The relationship between preoperative foot alignment and postoperative outcomes in patients who underwent initial total knee arthroplasty.","authors":"Aika Hishida, Hideki Hiraiwa, Izumi Kadono, Hidetoshi Yamaguchi, Takashi Okada, Chiaki Terai, Azusa Kayamoto, Yoshihiro Nishida","doi":"10.18999/nagjms.86.1.91","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.91","url":null,"abstract":"We compared the relationship between foot alignments and quality of life in patients who underwent initial total knee arthroplasty (TKA). Among the patients with knee osteoarthritis (KOA) who underwent TKA from May 2015 to May 2017 at our hospital, we focused on those in whom weight-bearing foot radiographs had been evaluated preoperatively. The hallux valgus angle and Meary angle were measured by preoperative radiography, and those with hallux valgus angles of 20 degrees or more were classified into the hallux valgus (HV) group, and those with Meary angles of 4 degrees or more into the high arch (HA) group. Also knee and ankle range of motion, knee pain Visual Analog Scale, and the 36-item short-form health survey (SF-36) were measured preoperatively and at discharge, and the amount of these changes was compared in the presence/absence of HV and HA. Regarding HV, there were no significant differences in any of these items between the HV and non-HV groups. However, the SF-physical function was significantly lower in the HA group than in the normal group. In addition, ankle dorsiflexion was lower in the HA group than that in the normal group, although this difference was not statistically significant. There was little improvement of the ankle dorsiflexion, and it was associated with deterioration of the physical function items of SF-36. In total knee arthroplasty patients with HA, physical therapy of the ankles and feet, as well as of the knees, was considered to enhance the improvement of physical function.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"91-103"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anxiety evaluated by the Hospital Anxiety and Depression Scale as a predictor of postoperative nausea and vomiting: a pilot study. 通过医院焦虑和抑郁量表评估焦虑，预测术后恶心和呕吐：一项试点研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.72

Tatsuro Yokoyama, Takahiro Tamura, Kazuki Nishida, Ryohei Ito, Kimitoshi Nishiwaki

{"title":"Anxiety evaluated by the Hospital Anxiety and Depression Scale as a predictor of postoperative nausea and vomiting: a pilot study.","authors":"Tatsuro Yokoyama, Takahiro Tamura, Kazuki Nishida, Ryohei Ito, Kimitoshi Nishiwaki","doi":"10.18999/nagjms.86.1.72","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.72","url":null,"abstract":"The incidence of postoperative nausea and vomiting (PONV) remains high, and improving the accuracy of PONV prediction remains challenging. The primary aim of this study is to examine the impact of anxiety scores evaluated using the Hospital Anxiety and Depression Scale (HADS) on the PONV prediction model. We hypothesized that anxiety and depression, quantified using the HADS, could improve the accuracy of the PONV predictive model. This pilot study evaluated 100 patients. The HADS was conducted by a self-evaluation method before thoracoscopic surgery for lung tumors, and the anesthesia method was standardized. The criterion was whether the nurse in charge of the patient who complained of PONV assessed that drug administration was necessary. As the main analysis, the odds ratio of the HADS score for predicting PONV was evaluated using multivariable logistic regression models. Further, the receiver operating characteristic (ROC) curves of the model with the HADS score added to the variables of without-anxiety predictors and the model with the variables of without-anxiety predictors only were compared. The anxiety score was significantly higher in the PONV group than in the no PONV group (P = 0.021). For predictive accuracy, the model that included age, sex, smoking history, history of PONV, and anxiety score had a higher area under the ROC curve than did the model excluding the anxiety score (P = 0.021). In conclusion, the findings indicate that the HADS is worth investigating as a predictor of PONV.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"72-81"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of nursing students' moral sensitivity questionnaire in Taiwan. 台湾护理学生道德敏感性问卷的开发与验证。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-02-01 DOI: 10.18999/nagjms.86.1.110

Hsiao-Lu Lee, Chiu-Mieh Huang

{"title":"Development and validation of nursing students' moral sensitivity questionnaire in Taiwan.","authors":"Hsiao-Lu Lee, Chiu-Mieh Huang","doi":"10.18999/nagjms.86.1.110","DOIUrl":"https://doi.org/10.18999/nagjms.86.1.110","url":null,"abstract":"Ethical literacy is a critical aspect of professional nursing development. It is considered an essential quality that nursing professionals should possess throughout their careers. Moral sensitivity serves as the foundation for developing ethical literacy. The objective of this study was to develop a reliable tool for assessing moral sensitivity among nursing students. The questionnaire was developed following a rigorous approach, consisting of three stages process, combining the Schwartz-Barcott and Kim hybrid model of concept development with the methodology suggested by Devellis and Waltz. A total of 297 nursing students (287 females, 10 males; mean age: 18.7 years) participated in the study, with five invalid questionnaires excluded from the analysis. The questionnaire's reliability was established through internal consistency and test-retest reliability analyses. Furthermore, the moral sensitivity questionnaire for nursing students demonstrated satisfactory validity through the results of construct, convergent and discriminant validation procedures. The study findings revealed a significant correlation between the internship performance of students and their overall moral sensitivity score. The questionnaire would be appropriated to be included as a supplemental measure for ethical literacy evaluation.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 1","pages":"110-120"},"PeriodicalIF":0.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10945222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0