Nagoya Journal of Medical Science最新文献_第5页

Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells. 神经节苷脂GD3/GD2阳性胶质瘤细胞分泌的外泌体在增强GD3/GD2阴性胶质瘤细胞的恶性表型和信号方面发挥关键作用。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.435

Mohammad Abul Hasnat, Yuhsuke Ohmi, Farhana Yesmin, Mariko Kambe, Yoshiyuki Kawamoto, Robiul H Bhuiyan, Momoka Mizutani, Noboru Hashimoto, Akiko Tsuchida, Yuki Ohkawa, Kei Kaneko, Orie Tajima, Keiko Furukawa, Koichi Furukawa

{"title":"Crucial roles of exosomes secreted from ganglioside GD3/GD2-positive glioma cells in enhancement of the malignant phenotypes and signals of GD3/GD2-negative glioma cells.","authors":"Mohammad Abul Hasnat, Yuhsuke Ohmi, Farhana Yesmin, Mariko Kambe, Yoshiyuki Kawamoto, Robiul H Bhuiyan, Momoka Mizutani, Noboru Hashimoto, Akiko Tsuchida, Yuki Ohkawa, Kei Kaneko, Orie Tajima, Keiko Furukawa, Koichi Furukawa","doi":"10.18999/nagjms.86.3.435","DOIUrl":"10.18999/nagjms.86.3.435","url":null,"abstract":"Neuroectoderm-derived tumors characteristically express gangliosides such as GD3 and GD2. Many studies have reported that gangliosides GD3/GD2 enhance malignant phenotypes of cancers. Recently, we reported that human gliomas expressing GD3/GD2 exhibited enhanced malignant phenotypes. Here, we investigated the function of GD3/GD2 in glioma cells and GD3/GD2-expressing glioma-derived exosomes. As reported previously, transfectant cells of human glioma U251 MG expressing GD3/GD2 showed enhanced cancer phenotypes compared with GD3/GD2-negative controls. When GD3/GD2-negative cells were treated with exosomes secreted from GD3/GD2-positive cells, clearly increased malignant properties were observed. Furthermore, increased phosphorylation of signaling molecules was detected after 5-15 min of exosome treatment, ie, higher tyrosine phosphorylation of platelet-derived growth factor receptor, focal adhesion kinase, and paxillin was found in treated cells than in controls. Phosphorylation of extracellular signal-regulated kinase-1/2 was also enhanced. Consequently, it is suggested that exosomes secreted from GD3/GD2-positive gliomas play important roles in enhancement of the malignant properties of glioma cells, leading to total aggravation of heterogenous cancer tissues, and also in the regulation of tumor microenvironments.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"435-451"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis. 韦多珠单抗对溃疡性结肠炎患者疗效的预测因素。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.407

Go Kajikawa, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Kota Uetsuki, Takashi Hirose, Tadashi Iida, Yasuyuki Mizutani, Kentaro Yamao, Takuya Ishikawa, Kazuhiro Furukawa, Hiroki Kawashima

{"title":"Predictors of the efficacy of vedolizumab in patients with ulcerative colitis.","authors":"Go Kajikawa, Tsunaki Sawada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Eri Ishikawa, Kota Uetsuki, Takashi Hirose, Tadashi Iida, Yasuyuki Mizutani, Kentaro Yamao, Takuya Ishikawa, Kazuhiro Furukawa, Hiroki Kawashima","doi":"10.18999/nagjms.86.3.407","DOIUrl":"10.18999/nagjms.86.3.407","url":null,"abstract":"Vedolizumab is a treatment option for ulcerative colitis but data on predictors of treatment response remain insufficient to establish personalized treatment strategies. We aimed to investigate the real-world effectiveness of vedolizumab in adult patients with ulcerative colitis and explore factors involved in predicting treatment response. This single-center, single-arm, prospective observational study included 26 patients with clinically active ulcerative colitis patients' characteristics at baseline, epidemiological information, existing treatment, clinical activity index score, endoscopic score, and blood test data were collected. Serum levels of tumor necrosis factors alpha, interferon gamma, interleukin-4, interleukin-6, interleukin-10, interleukin-17, soluble mucosal addressin cell adhesion molecule 1, and soluble vascular cell adhesion molecule 1 were measured. Patient characteristics in the remission and non-remission groups were compared based on these parameters. Clinical remission at 6 weeks of treatment occurred in 9 (35%) of the 26 patients. At 14 weeks, clinical remission was observed in 11 patients (42%). There were no significant differences pertaining to age, sex, duration of disease, extent of disease, steroid resistance, or prior treatment with biological agents among the two groups after 14 weeks of treatment. Hemoglobin ≥ 11.5 g/dL (odds ratio, 15.0; 95% confidence interval, 1.50-149; P=0.014) and soluble mucosal addressin cell adhesion molecule 1 ≥ 765 pg/mL (odds ratio, 17.3; 95% confidence interval, 2.36-127; P=0.004) were significant factors. In conclusion, hemoglobin and serum soluble mucosal addressin cell adhesion molecule 1 levels are factors correlated with the therapeutic efficacy of vedolizumab.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"407-421"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delivery management of pregnant blue rubber bleb nevus syndrome patients: a case report and literature review. 蓝色橡皮样痣综合征孕妇的分娩管理：病例报告和文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.507

Mie Nagahama, Yoshitsugu Chigusa, Atsuko Shiraki, Yui Takei, Ayaka Yamaguchi, Toshiyuki Mizota, Maya Komatsu, Takashi Nomura, Moritoki Egi, Masaki Mandai, Haruta Mogami

{"title":"Delivery management of pregnant blue rubber bleb nevus syndrome patients: a case report and literature review.","authors":"Mie Nagahama, Yoshitsugu Chigusa, Atsuko Shiraki, Yui Takei, Ayaka Yamaguchi, Toshiyuki Mizota, Maya Komatsu, Takashi Nomura, Moritoki Egi, Masaki Mandai, Haruta Mogami","doi":"10.18999/nagjms.86.3.507","DOIUrl":"10.18999/nagjms.86.3.507","url":null,"abstract":"Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular disorder characterized by multifocal venous malformations (VMs). Little is known about the perinatal management of pregnant women with BRBNS owing to the limited number of reported cases. We present the case of a 36-year-old primigravida with BRBNS who underwent an uneventful cesarean section under spinal anesthesia for breech presentation. A thorough systemic examination revealed VMs in various organs, including the skin, conjunctiva, larynx, gastrointestinal tract, lungs, and vulva. Prior to spinal anesthesia, careful examination using imaging modalities was conducted to assess the spinal and epidural involvement of the VMs to avoid complications, including accidental puncture of the VMs, associated bleeding, and epidural hematoma. In pregnant women with BBNS, it is imperative to scrutinize the localization and distribution of VMs throughout the body to anticipate potential complications and select the appropriate delivery mode and anesthetic management.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"507-513"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adenosine triphosphate release inhibitors targeting pannexin1 improve recovery after spinal cord injury. 以 pannexin1 为靶点的三磷酸腺苷释放抑制剂可改善脊髓损伤后的恢复。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.392

Kazuaki Morishita, Hiroaki Nakashima, Masaaki Machino, Sadayuki Ito, Naoki Segi, Yuichi Miyairi, Yoshinori Morita, Shiro Imagama

{"title":"Adenosine triphosphate release inhibitors targeting pannexin1 improve recovery after spinal cord injury.","authors":"Kazuaki Morishita, Hiroaki Nakashima, Masaaki Machino, Sadayuki Ito, Naoki Segi, Yuichi Miyairi, Yoshinori Morita, Shiro Imagama","doi":"10.18999/nagjms.86.3.392","DOIUrl":"10.18999/nagjms.86.3.392","url":null,"abstract":"Traumatic spinal cord injury is characterized by immediate and irreversible tissue loss at the lesion site and secondary tissue damage. Secondary injuries should, in principle, be preventable, although no effective treatment options currently exist for patients with acute spinal cord injury. Traumatized tissues release excessive amounts of adenosine triphosphate and activate the P2X purinoceptor 7/pannexin1 complex, which is associated with secondary injury. We investigated the neuroprotective effects of the blue dye Brilliant Blue FCF, a selective inhibitor of P2X purinoceptor 7/pannexin1 that is approved for use as a food coloring, by comparing it with Brilliant Blue G, a P2X7 purinoceptor antagonist, and carbenoxolone, which attenuates P2X purinoceptor 7/pannexin1 function, in a rat spinal cord injury model. Brilliant Blue FCF administered early after spinal cord injury reduced spinal cord anatomical damage and improved motor recovery without apparent toxicity. Brilliant Blue G had the highest effect on this neurological recovery, with Brilliant Blue FCF and carbenoxolone having comparable improvement. Furthermore, Brilliant Blue FCF administration reduced local astrocytic and microglial activation and neutrophil infiltration, and no differences in these histological effects were observed between compounds. Thus, Brilliant Blue FCF protects spinal cord neurons after spinal cord injury and suppresses local inflammatory responses as well as Brilliant Blue G and carbenoxolone.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"392-406"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appendiceal adenocarcinoma associated with Amyand's hernia: a case report. 阑尾腺癌伴发阿米氏疝：病例报告。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.514

Kotaro Momota, Koji Shibata, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Hideki Murakami

{"title":"Appendiceal adenocarcinoma associated with Amyand's hernia: a case report.","authors":"Kotaro Momota, Koji Shibata, Hideo Miyake, Hidemasa Nagai, Yuichiro Yoshioka, Norihiro Yuasa, Hideki Murakami","doi":"10.18999/nagjms.86.3.514","DOIUrl":"10.18999/nagjms.86.3.514","url":null,"abstract":"We encountered a rare case of appendiceal carcinoma associated with Amyand's hernia, which was difficult to diagnose preoperatively. A 74-year-old man presented to our hospital with right lower abdominal pain. A hard mass was palpable in the right lower abdomen, and blood tests showed a slightly elevated inflammatory response. Computed tomography revealed a 7 × 5 cm mass with indistinct borders and heterogeneous internal density extending from the cecum to the right lower abdominal wall. We diagnosed appendiceal abscess, however, percutaneous biopsy which was performed for differential diagnosis with appendiceal carcinoma showed no malignancy. Thereafter, the patient was followed up. Two months later, a blood test showed insignificant changes in the inflammatory response and a high serum carcinoembryonic antigen level (48.6 ng/mL). An ultrasound showed a mass contiguous to the appendix, extending to the abdominal wall, with abundant blood flow signals. Fluorodeoxyglucose-positron emission tomography showed a high accumulation of fluorodeoxyglucose in the mass. Four months after the initial visit, the patient had an open ileocecal resection combined with an abdominal wall resection based on the preoperative diagnosis of appendiceal carcinoma invading the abdominal wall. During laparotomy, an enlarged appendix tip extended from the internal inguinal ring outside the inferior epigastric artery to the abdominal wall. Histopathological examination of the appendiceal tumor revealed well-differentiated adenocarcinoma, T4b (abdominal wall), N0, Ly0, and V0. When a right lower abdominal mass extends from the cecum to the abdominal wall, appendiceal tumors associated with Amyand's hernia should be considered.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"514-523"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild hyperthermia upregulates PD-L1 in the tumor microenvironment and enhances antitumor efficacy of PD-L1 blockade in murine squamous cell carcinoma. 轻度热疗可上调肿瘤微环境中的 PD-L1 并增强 PD-L1 阻断剂在小鼠鳞状细胞癌中的抗肿瘤疗效。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.497

Yuya Ohta, Norihisa Ichimura, Satoshi Yamaguchi, Go Ohara, Noriyuki Yamamoto, Yoshiyuki Itoh, Keiichiro Yamada, Seiji Nakamura, Hideharu Hibi

{"title":"Mild hyperthermia upregulates PD-L1 in the tumor microenvironment and enhances antitumor efficacy of PD-L1 blockade in murine squamous cell carcinoma.","authors":"Yuya Ohta, Norihisa Ichimura, Satoshi Yamaguchi, Go Ohara, Noriyuki Yamamoto, Yoshiyuki Itoh, Keiichiro Yamada, Seiji Nakamura, Hideharu Hibi","doi":"10.18999/nagjms.86.3.497","DOIUrl":"10.18999/nagjms.86.3.497","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) has a low five-year survival rate because of its high rate of recurrence and metastasis. After surgical resection or radiation, the main treatments for HNSCC, patients sometimes experience functional or aesthetic disorders. Therefore, there is a great demand for the development of non-surgical treatment strategies to improve clinical outcomes and patients' quality of life. One such non-surgical treatment is mild hyperthermia (mHT). Many studies have investigated combination treatments with mHT and immune checkpoint inhibitors in preclinical settings. However, there have been no detailed reports on the effects of mHT on immune checkpoint molecules. Here, we investigated the effects of mHT on the tumor microenvironment (TME), particularly on programmed cell death receptor-1 (PD-1)/programmed cell death ligand-1 (PD-L1), in SCCVII cells and a squamous cell carcinoma mouse model. First, we found that PD-L1 mRNA levels and surface PD-L1 expression significantly increased after mHT. Second, a single tumor model was used to determine the effect of HT on the TME. mHT enhanced the accumulation of CD4+ and CD8+ T cells, elevated PD-L1 expression in the TME, and decreased the PD-1 positive rate of CD4+ T cells. Finally, using a bilateral tumor model, we found that anti-PD-L1 monotherapy and combination therapy resulted in longer survival than the isotype control or mHT monotherapy. Moreover, the combination therapy resulted in a significantly higher survival rate than anti-PD-L1 monotherapy. In conclusion, our findings elucidate changes in PD-L1 expression in the TME and strengthen the rationale for mHT and PD-L1 blockade combination therapy.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"497-506"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decubitus ulcer infection and bacteremia due to tazobactam/piperacillin-resistant Veillonella parvula. 耐他唑巴坦/哌拉西林维龙菌引起的褥疮感染和菌血症。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.524

Shoko Sahara, Teruhisa Kinoshita, Tomomi Amano, Misa Ishida, Takashi Yamakita, Norio Takimoto, Keisuke Oka

{"title":"Decubitus ulcer infection and bacteremia due to tazobactam/piperacillin-resistant Veillonella parvula.","authors":"Shoko Sahara, Teruhisa Kinoshita, Tomomi Amano, Misa Ishida, Takashi Yamakita, Norio Takimoto, Keisuke Oka","doi":"10.18999/nagjms.86.3.524","DOIUrl":"10.18999/nagjms.86.3.524","url":null,"abstract":"This is the first case report of decubitus infection and bacteremia due to Veillonella parvula (V. parvula). A patient in his 70s with pre-existing diabetes mellitus was admitted with decubitus infection, and tazobactam/piperacillin treatment was initiated. Tazobactam/piperacillin-resistant V. parvula was detected in the blood and decubitus site cultures. The antimicrobial treatment was changed to clindamycin and cefmetazole. Antimicrobial therapy was administered for 28 days. The patient was transferred to a convalescent hospital. V. parvula occasionally causes infection in immunocompromised patients with underlying diseases, such as diabetes. An appropriate evaluation by culture test is important for diagnosis, treatment, and recurrence prevention. Tazobactam/piperacillin is often used in the treatment of multi-bacterial infections such as decubitus infections. V. parvula may be resistant to tazobactam/piperacillin, and this possibility should be taken into account when administering treatment.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"524-530"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative transverse carpal muscle during endoscopic carpal tunnel release: a case report. 内窥镜腕管松解术中的术中腕横肌：病例报告。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.531

Shunpei Hama, Koji Moriya, Naoto Tsubokawa, Yutaka Maki, Hiroaki Nakamura

引用次数: 0

Our experience in repairs using the native esophagus such as the Foker and Gazi methods in the management of patients with long-gap esophageal atresia. 在治疗长间隙食道闭锁患者时，我们利用原生食道进行修复的经验，如 Foker 和 Gazi 方法。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.479

Cem Kaya, Alparslan Kapisiz, Sibel Eryilmaz, Zafer Turkyilmaz, Ramazan Karabulut, Leyla Turker, Ibrahim Murat Hirfanoglu, Ebru Ergenekon, Canan Turkyilmaz, Kaan Sonmez

{"title":"Our experience in repairs using the native esophagus such as the Foker and Gazi methods in the management of patients with long-gap esophageal atresia.","authors":"Cem Kaya, Alparslan Kapisiz, Sibel Eryilmaz, Zafer Turkyilmaz, Ramazan Karabulut, Leyla Turker, Ibrahim Murat Hirfanoglu, Ebru Ergenekon, Canan Turkyilmaz, Kaan Sonmez","doi":"10.18999/nagjms.86.3.479","DOIUrl":"10.18999/nagjms.86.3.479","url":null,"abstract":"This study aimed to share our experience with infants with repaired long-gap esophageal atresia (LGEA) using the native esophagus and Foker and Gazi methods. We retrospectively analyzed the medical records of 10 patients with LGEA (six with pure esophageal atresia [EA], and four with distal trachea-esophageal fistula [TEF] + EA). The mean length between the esophageal pouches was 5.9 cm (4-9 cm). Five Foker methods, three Gazi methods, and two delayed primary repairs after a daily bougie were performed an average of 19.3 days after the first surgery and 26.4 days after the final esophageal anastomosis. For the Foker technique, it was 36.1 days. Their first oral intake was 10.2 days, and their transition to full enteral food was 26.2 days. An esophageal leak was detected in six patients. Fundoplication and dilatations were performed for three and four patients, respectively. For good results, LGEA patients should be operated on at least under the supervision of an experienced surgeon in specialized centers, and the team should be familiar with the techniques for using the native esophagus.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"479-486"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary study of the effect of the web application on caregiver burden in dementia and behavioural and psychological symptoms of dementia. 关于网络应用对痴呆症护理负担以及痴呆症行为和心理症状影响的初步研究。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2024-08-01 DOI: 10.18999/nagjms.86.3.383

Yasuyuki Goto, Mina Suematsu, Takahiro Imaizumi, Yusuke Suzuki

{"title":"Preliminary study of the effect of the web application on caregiver burden in dementia and behavioural and psychological symptoms of dementia.","authors":"Yasuyuki Goto, Mina Suematsu, Takahiro Imaizumi, Yusuke Suzuki","doi":"10.18999/nagjms.86.3.383","DOIUrl":"10.18999/nagjms.86.3.383","url":null,"abstract":"This study aimed to investigate if our web application could be a viable intervention for providing caregivers with information on resilient coping strategies for the reduction of their burden, thereby leading to the alleviation of behavioural and psychological symptoms of dementia (BPSD). We recruited outpatients with dementia and informal caregiver dyads at Nagoya University Hospital from April 2022 to October 2022. The caregivers were asked to have the web application installed on their smartphones during the study period and answer the following two self-administered questionnaires once a month for 3 months: (a) Abe's BPSD Score (ABS), which assesses BPSD, and (b) the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI) score, which measures caregiver burden. Thirteen patients and informal caregiver dyads were enrolled in this study. The caregivers exchanged information on the care of patients with dementia in the virtual community using the web application during the study period. Upon entry, J-ZBI scores were correlated with ABSs (r = 0.65). Linear mixed-effects model revealed the average J-ZBI scores decreased over time with significance (p = 0.013), however, the average ABSs did not change during the study period. This is the first study to show that our web application reduces caregiver burden. However, to confirm the efficacy of our web application, further investigations are required.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"86 3","pages":"383-391"},"PeriodicalIF":0.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0