Nagoya Journal of Medical Science最新文献_第4页

Knacks and pitfalls of retroperitoneal sarcoma surgery, part 3: resection of tumors involving large retroperitoneal vessels. 腹膜后肉瘤手术的技巧和陷阱，第3部分：累及腹膜后大血管的肿瘤切除术。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-02-01 DOI: 10.18999/nagjms.88.1.24

Yukihiro Yokoyama, Masaki Sunagawa

{"title":"Knacks and pitfalls of retroperitoneal sarcoma surgery, part 3: resection of tumors involving large retroperitoneal vessels.","authors":"Yukihiro Yokoyama, Masaki Sunagawa","doi":"10.18999/nagjms.88.1.24","DOIUrl":"10.18999/nagjms.88.1.24","url":null,"abstract":"Retroperitoneal sarcomas (RPSs) often involve major vessels such as the iliac arteries/veins, inferior vena cava (IVC), and abdominal aorta, posing significant surgical challenges. Resection of RPSs involving large vessels requires advanced vascular techniques and multidisciplinary collaboration. In Part 3 of this series, technical strategies, pitfalls, and case-based insights for managing RPSs with large vessel involvement are described based on operative experience at a high-volume sarcoma center. Surgical approaches to iliac vessels, IVC resection with or without tumor thrombus, and aortic contact are described. Iliac vessel involvement may require in situ or staged vascular grafting. IVC resection with or without reconstruction is feasible in the presence of a thrombus or direct invasion, but the resection depends on hemodynamic tolerance and collateral circulation. Tumors with IVC thrombus extending into the right atrium require cardiopulmonary bypass. Preoperative arterial embolization and intraoperative ultrasound help minimize blood loss and guide resection margins. Dissection without aortic resection is often possible even when the tumor is close to the abdominal aorta. RPSs with vascular invasion can be safely resected using tailored strategies if the institution is prepared. Surgical expertise in retroperitoneal vascular anatomy and collaboration across specialties are essential to ensure safe and effective oncologic outcomes.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 1","pages":"24-37"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective study on the pathology and short-term outcomes of arthroscopic repair for intratendinous, bursal-side, and articular-side tears: comparison after conversion to full-thickness tears. 关节镜下修复肌腱内、滑囊侧和关节侧撕裂的病理学和短期疗效回顾性研究：转化为全层撕裂后的比较。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-02-01 DOI: 10.18999/nagjms.88.1.49

Yukihiro Kajita, Yohei Harada, Ryosuke Takahashi, Ryosuke Sagami, Yusuke Iwahori

{"title":"A retrospective study on the pathology and short-term outcomes of arthroscopic repair for intratendinous, bursal-side, and articular-side tears: comparison after conversion to full-thickness tears.","authors":"Yukihiro Kajita, Yohei Harada, Ryosuke Takahashi, Ryosuke Sagami, Yusuke Iwahori","doi":"10.18999/nagjms.88.1.49","DOIUrl":"10.18999/nagjms.88.1.49","url":null,"abstract":"Partial-thickness rotator cuff tears (PTRCTs) are classified into intratendinous tears (ITT), bursal-side tears (BST), and articular-side tears (AST). ITT is relatively rare, and many aspects of its clinical presentation remain unknown. Moreover, there are few reports on arthroscopic rotator cuff repair (ARCR) of ITTs. To the best of our knowledge, few reports have compared the treatment outcomes of ARCR with those of BST, AST, and ITT. Patients who were diagnosed with ITT based on intraoperative findings and who could be followed up for at least 1 year postoperatively were included in this study. In all patients with PTRCTs, a complete tear was created and repaired via suture bridge techniques. Among the ITT, BST, and AST groups, the frequency of PTRCTs (ITT, BST, AST), patient background (age, sex, history of trauma), acromiohumeral distance (AHD), critical shoulder angle (CSA), lateral acromial angle (LAA), acromial morphology, Japanese Orthopaedic Association (JOA) score, and re-tear rate were compared. Fifteen patients underwent ARCR on ITT, 95 patients underwent BST, and 39 patients underwent AST. There were no significant differences in age, sex, or frequency of traumatic rotator cuff tears. The preoperative CSA showed significant differences; however, no significant differences were observed among the three groups for AHD, LAA, and acromion morphology. There were no significant differences in operation time, JOA score, or re-tear rate. The results of ARCR for ITT were good and may be a viable option for patients resistant to conservative treatment.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 1","pages":"49-58"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards building a meaningful clinical training program: a comparison of obstetrics and gynecology undergraduate medical education in Germany and Japan. 建立有意义的临床培训计划：德国和日本妇产科本科医学教育的比较。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-02-01 DOI: 10.18999/nagjms.88.1.170

Masato Yoshihara, Lina Roisenwasser, Tanja N Fehm, Hiroshi Nishigori, Hiroaki Kajiyama

{"title":"Towards building a meaningful clinical training program: a comparison of obstetrics and gynecology undergraduate medical education in Germany and Japan.","authors":"Masato Yoshihara, Lina Roisenwasser, Tanja N Fehm, Hiroshi Nishigori, Hiroaki Kajiyama","doi":"10.18999/nagjms.88.1.170","DOIUrl":"10.18999/nagjms.88.1.170","url":null,"abstract":"Recent reforms in Japan's medical education, particularly the revision of the Model Core Curriculum, have emphasized hands-on clinical training to improve student competencies. Despite growing awareness, implementation varies across institutions, and clinical education remains largely observational with limited procedural experience. In contrast, Germany's medical education, rooted in practical training since the Meiji period influence, integrates structured clinical experience throughout the undergraduate curriculum, culminating in the sixth-year \"Praktisches Jahr\". The present study compares undergraduate clinical training in obstetrics and gynecology (OB-GYN) between Japan and Germany, focusing on the author's experience at the University Hospital of Düsseldorf and Nagoya University Hospital. The OB-GYN training program at Düsseldorf emphasizes direct patient care, clinical reasoning, and active learning through the Mini-Clinical Evaluation Exercise, problem-based learning, and simulation-based ultrasound practice. Educator involvement is institutionalized, and dual-feedback systems enhance accountability. The Nagoya program focuses on simulations and observations, with structured learning in professionalism, basic procedures, and journal clubs, but lacks consistent feedback mechanisms and opportunities for independent clinical reasoning. Therefore, Japan may enhance its undergraduate clinical education by incorporating Germany's practical training approaches, including structured inpatient case assignments, bidirectional feedback systems, and the greater integration of clinical decision-making. These insights support curriculum reforms that foster student engagement and professional competence. Future efforts need to align these adaptations with Japan's unique educational and institutional contexts to ensure sustainable improvements in medical education.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 1","pages":"170-177"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between multiple urinary trace metal elements and lumbar bone mineral density in adults. 多种尿微量金属元素与成人腰椎骨密度的关系。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2026-02-01 DOI: 10.18999/nagjms.88.1.122

Renhao Zhang, Tianyu Fu, Fengyue Guo, Guoli Zhang, Xingshi Wang, Jiusong Wang, Zhengze Zhang, Kai Meng

{"title":"Association between multiple urinary trace metal elements and lumbar bone mineral density in adults.","authors":"Renhao Zhang, Tianyu Fu, Fengyue Guo, Guoli Zhang, Xingshi Wang, Jiusong Wang, Zhengze Zhang, Kai Meng","doi":"10.18999/nagjms.88.1.122","DOIUrl":"10.18999/nagjms.88.1.122","url":null,"abstract":"Urinary trace metal elements are key biomarkers for assessing exposure to toxic metals, and are significant contributors to osteoporosis (OP). Epidemiological research examining the connection between adult bone mineral density (BMD) and trace metal elements exposure is still very scarce, nevertheless. The study aims to clarify the association between trace metal elements exposure and BMD. This cross-sectional study included 3,441 adults (aged 20 to 59) from 2011 to 2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression analysis, subgroup analysis, smoothing curve fitting and threshold effect analysis were conducted to explore the association between four urinary trace metal elements (barium, cesium, antimony, and tin) and BMD. We found that urinary cesium, antimony, and tin were positively associated with lumbar BMD, while urinary barium demonstrated an inverted U-shaped association in US adults. The results of this study are helpful for the development of strategies for bone mineral density management.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"88 1","pages":"122-137"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147934932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new understanding of the mechanical mechanism of posterior vaginal prolapse based on magnetic resonance imaging. 基于磁共振成像对阴道后脱垂力学机制的新认识。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.766

Qiaoling Shi, Zhongyuan Qiu, Yanfeng Song, Tongfei Wang, Yan Li, Qiulan Dai, Peifang Chen

{"title":"A new understanding of the mechanical mechanism of posterior vaginal prolapse based on magnetic resonance imaging.","authors":"Qiaoling Shi, Zhongyuan Qiu, Yanfeng Song, Tongfei Wang, Yan Li, Qiulan Dai, Peifang Chen","doi":"10.18999/nagjms.87.4.766","DOIUrl":"10.18999/nagjms.87.4.766","url":null,"abstract":"According to the theory of force translation, the mechanical mechanism underlying posterior vaginal prolapse (PVP) can be speculated upon by measuring the displacement of the pelvic floor supporting structures with magnetic resonance imaging (MRI). Displacement of the posterior vaginal vault (Vp), the square root of the area under the curve between the sacrococcygeal inferior pubic point line (SCIPP) and the middle third of the posterior vaginal wall (PVW) (Sc'), the midperineal body (mid-PB), the H line, the M line, the estimated levator ani subtended volume (eLASV) and the levator hiatus width (LHW) were measured while participants performed during the Valsalva maneuver on MR images. These measurements were evaluated at different stages of PVP (n = 10, 12, 9, and 17 for stages 0, I, II, and ≥ III, respectively) with one-way analysis of variance (ANOVA), and the displacement difference ratio was used to describe the distribution process of force transfer. In Phase 1, the displacement difference ratios of Vp and Sc' far exceeded those of mid-PB and eLASV; in Phase 2, the displacement difference ratio of eLASV increased significantly to more than ten times that of in Phase 1, whereas the displacement difference ratio of the mid-PB was unchanged; in Phase 3, the mid-PB displacement difference ratio increased by nearly 33 times that in Phase 2. Specific interactions between the pelvic floor muscles and connective tissues may occur during the course of PVW prolapse.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"766-775"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The frozen elephant trunk technique. 冷冻象鼻技术。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.597

Masato Mutsuga

{"title":"The frozen elephant trunk technique.","authors":"Masato Mutsuga","doi":"10.18999/nagjms.87.4.597","DOIUrl":"10.18999/nagjms.87.4.597","url":null,"abstract":"The frozen elephant trunk (FET) technique, which was an advanced version of the elephant trunk technique, is now the gold standard for distal aortic arch repair. The major advantage is that the distal anastomosis is fixed by the stent; therefore, anastomosis that has been used to be performed in the descending aorta can be performed on the more proximal side of the aortic arch. The FET technique has become widely used, causing the increased risk of spinal cord injury (SCI) to become a major concern. As the FET fixes the distal side, the risk of SCI increases depending on its landing zone and depth. To avoid SCI, stent length should be limited to about 10 cm, and the use stents of 15 cm in length or landing beyond Th8 should be avoided. Another problem after the FET technique is the distal site new entry (d-SINE) in the mid- and long-term stages. d-SINE can also occur after thoracic endovascular aortic repair (TEVAR), mainly due to its oversizing. The spring-back-force, which is also related to the stent strength, is also said to be a cause of d-SINE after the FET technique. I herein review the FET technique, its surgical outcomes, and complications.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"597-606"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Situation of dementia measured by Revised Hasegawa's Dementia Scale and its associated factors in Thaibinh, Vietnam. 用修订的长谷川痴呆量表测量越南泰平地区痴呆情况及其相关因素

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.691

Tran Thi Phuong, Thu Nandar Saw, Vu Phong Tuc, Dang Thi Van Quy, Nguyen Van Tien, Nguyen Ngoc Anh, Nobuyuki Hamajima, Yu Mon Saw

{"title":"Situation of dementia measured by Revised Hasegawa's Dementia Scale and its associated factors in Thaibinh, Vietnam.","authors":"Tran Thi Phuong, Thu Nandar Saw, Vu Phong Tuc, Dang Thi Van Quy, Nguyen Van Tien, Nguyen Ngoc Anh, Nobuyuki Hamajima, Yu Mon Saw","doi":"10.18999/nagjms.87.4.691","DOIUrl":"10.18999/nagjms.87.4.691","url":null,"abstract":"As Vietnam's population has been aging, dementia is becoming more prevalent. This study aims to identify the prevalence of dementia and its related factors among older adults in Thaibinh Province, Vietnam. A cross-sectional study was conducted among 762 older adults living in two communes of Thaibinh Province, Vietnam. The Revised Hasegawa's Dementia Scale (HDS-R) Vietnamese version was used as a screening instrument for dementia. Participants were interviewed using face-to-face method. Descriptive statistics and multivariable logistic regression analyses were calculated in this study. The overall rate of dementia among older adults was 22.7%. Female were more likely to develop dementia than male participants (adjusted odds ratio [AOR] = 6.5; 95% confidence interval (95% CI), 2.71-15.64). Participants aged 70 or older, who had personal income of 3 million Vietnam Dong and higher (AOR = 5.7; 95% CI, 3.01-10.77), who smoke or used to smoke, who had poor vision ability (AOR = 8.9; 95% CI, 1.77-44.77), who had hypertension (unadjusted odds ratio [UOR] = 2.0; 95% CI, 1.24-3.38), and who with less ability of self-eating (UOR = 10.6; 95% CI, 3.31-33.73) were more likely to have dementia. Participants who had education levels of primary school and higher and who self-rated health as healthy (AOR = 0.5; 95% CI, 0.23-0.95) were less likely to have dementia. The prevalence of dementia among older adults was quite high in Vietnam. Associated factors including education level and smoking should be considered in future studies to prevent dementia among aging population.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"691-705"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful treatment with sintilimab plus anlotinib for SMARCA4-deficient non-small cell lung cancer withMET exon 14 skipping: a case report. sintilmab联合anlotinib成功治疗伴有met外显子14跳脱的smarca4缺陷非小细胞肺癌1例报告

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.808

Hongfei Zhao, Chi Zhang, Dongmei Chen, Wei Ye, Qingming Shi

{"title":"Successful treatment with sintilimab plus anlotinib for SMARCA4-deficient non-small cell lung cancer withMET exon 14 skipping: a case report.","authors":"Hongfei Zhao, Chi Zhang, Dongmei Chen, Wei Ye, Qingming Shi","doi":"10.18999/nagjms.87.4.808","DOIUrl":"10.18999/nagjms.87.4.808","url":null,"abstract":"SMARCA4-deficient non-small-cell lung cancer (SD-NSCLC) is a rare and highly aggressive epithelial tumor that originates in the lungs. SD-NSCLCs are more prevalent among male smokers, lacks mutations of the mesenchymal-epithelial transition g (MET) gene, and does not have an established treatment plan. Herein, we present a unique case of an SD-NSCLC, an adenocarcinoma with a MET14 skipping mutation, in the left upper lung lobe which was classified as cT4N3M1a stage IVa. Next-generation sequencing revealed a D1010H skip mutation in exon 14 of MET, and immunohistochemistry indicated a programmed death ligand 1 expression level of 90%. Owing to financial constraints and concerns regarding chemotherapy, the patient declined MET inhibitor-targeted therapy and chemotherapy. Instead, the patient received sintilimab and anlotinib. Following two treatment cycles, a notable reduction in the lesions in the left upper lobe and a significant decrease in lung metastases were observed, and the patient has attained a progression free survival of >2 years. This case represents the initial documentation of SD-NSCLC featuring MET14 skipping mutations and its effective management with programmed death protein 1 inhibitors, in conjunction with anti-angiogenic agents. We believe that the combination of sintilimab and anlotinib can be a viable therapeutic approach for the treatment of SD-NSCLCs.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"808-813"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retrospective study of post-radiation sarcoma from three institutions in Japan with a review of the literature. 日本三家机构放射后肉瘤的回顾性研究及文献综述。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.747

Tomohiro Miyazaki, Naoki Oike, Takashi Ariizumi, Yudai Murayama, Hiroshi Hatano, Tetsuro Yamagishi, Yoshiaki Tei, Akira Ogose, Hiroyuki Kawashima

{"title":"A retrospective study of post-radiation sarcoma from three institutions in Japan with a review of the literature.","authors":"Tomohiro Miyazaki, Naoki Oike, Takashi Ariizumi, Yudai Murayama, Hiroshi Hatano, Tetsuro Yamagishi, Yoshiaki Tei, Akira Ogose, Hiroyuki Kawashima","doi":"10.18999/nagjms.87.4.747","DOIUrl":"10.18999/nagjms.87.4.747","url":null,"abstract":"This study investigated incidence, clinical characteristics, and outcomes of post-radiation sarcoma, a rare but severe complication following radiotherapy. Post-radiation sarcoma is a malignant tumor arising within irradiated areas after a latency period, histologically different from the primary tumor. We retrospectively analyzed cases from January 2000 to January 2025 at three institutions in Japan, employing widely accepted diagnostic criteria. Patient characteristics, treatment details, oncologic outcomes, and prognostic factors were evaluated. Our study included 14 patients with various primary cancers, including three breast cancers, three prostate cancers, and one each of other cancer types. Among the cases, six had osteosarcoma, six had undifferentiated pleomorphic sarcoma, one had chondrosarcoma, and one had malignant peripheral nerve sheath tumor, predominantly occurring in the trunk. The median latency period from last irradiation to diagnosis was 9.9 years (range, 3.0-19.5 years). The median total radiation dose administered before post-radiation sarcoma diagnosis was 52.5 Gy (range, 12-74 Gy). The median overall survival and probability of 5-year overall survival were 2.6 years and 46.8%, respectively. The only factor that tended to correlate with prognosis was whether complete resection was achieved (P = 0.09). A literature review confirmed an increasing number of post-radiation sarcoma cases following radiotherapy for prostate cancer in recent years. The incidence of post-radiation sarcoma is expected to rise alongside the number of patients undergoing radiotherapy. Early detection and appropriate treatment are essential to improve prognosis, highlighting the need for careful long-term monitoring of patients receiving radiotherapy for post-radiation sarcoma.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"747-765"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leg dominance affects the appearance of osteoarthritis of the lumbar facet joints at L5-S. 腿部优势影响L5-S腰椎小关节骨关节炎的外观。

IF 0.9 4区医学

Nagoya Journal of Medical Science Pub Date : 2025-11-01 DOI: 10.18999/nagjms.87.4.706

Shunsuke Kanbara, Tomohiro Matsumoto, Takayuki Sugino, Shingo Kurahashi, Yuya Ito, Kenshiro Fukui, Takahiro Wakayama, Kyohei Kaneko, Keigo Ito

{"title":"Leg dominance affects the appearance of osteoarthritis of the lumbar facet joints at L5-S.","authors":"Shunsuke Kanbara, Tomohiro Matsumoto, Takayuki Sugino, Shingo Kurahashi, Yuya Ito, Kenshiro Fukui, Takahiro Wakayama, Kyohei Kaneko, Keigo Ito","doi":"10.18999/nagjms.87.4.706","DOIUrl":"10.18999/nagjms.87.4.706","url":null,"abstract":"The influence of leg dominance on lumbar intervertebral joint deformity and osteoarthritis remains poorly understood, particularly across different age groups. A clearer understanding of this relationship could improve rehabilitation strategies and patient outcomes. This study investigated 109 patients with spinal disorders who had not undergone spinal surgery and underwent computed tomography after myelography between May 2023 and January 2024 at our hospital. Lateral lumbar radiographs in a neutral standing position were used to evaluate lumbar lordosis (L1-S), lower lumbar lordosis (L4-S), pelvic incidence, and sacral slope. Hand and leg dominance were self-reported before admission, and observed leg dominance (determined by the leg used to climb onto a platform) was recorded. Lumbar facet joint osteoarthritis at each disk level was assessed using computed tomography imaging. Most participants reported right-side dominance for both the hand (101 participants, 92.7%) and leg (98 participants, 90%). Concordance between hand and leg dominance was observed in 102 (93.6%) participants. The most pronounced difference in osteoarthritis prevalence between the dominant and nondominant-leg sides at L5-S occurred among participants aged 45-64 years. Osteoarthritis on the dominant-leg side developed earlier (after age 40) than on the nondominant-leg side, where it emerged approximately a decade later. These findings suggest that leg dominance plays a role in lumbar facet joint degeneration, underscoring the need for further research and clinical consideration.","PeriodicalId":49014,"journal":{"name":"Nagoya Journal of Medical Science","volume":"87 4","pages":"706-718"},"PeriodicalIF":0.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12805124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0