Acta Neuropsychiatrica最新文献_第8页

The influence of peer non-suicidal self-harm on young adults' urges to self-harm: experimental study. 同伴非自杀性自残对青少年自残冲动的影响:实验研究。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-11-28 DOI: 10.1017/neu.2023.51

Alexandra Pitman, Millie Lowther, Alexandra Pike, Jessica Davies, Angharad de Cates, Joshua E J Buckman, Oliver Robinson

{"title":"The influence of peer non-suicidal self-harm on young adults' urges to self-harm: experimental study.","authors":"Alexandra Pitman, Millie Lowther, Alexandra Pike, Jessica Davies, Angharad de Cates, Joshua E J Buckman, Oliver Robinson","doi":"10.1017/neu.2023.51","DOIUrl":"10.1017/neu.2023.51","url":null,"abstract":"Objective: To test the hypothesis that exposure to peer self-harm induces adolescents' urges to self-harm and that this is influenced by individual suggestibility.Methods: We recruited 97 UK-based adults aged 18-25 years with a recent history of self-harm, measuring baseline suggestibility (Resistance to Peer Influence; RPI) and perceived ability to control urges to self-harm (using an adapted item from the Self-Efficacy to Resist Suicidal Action scale; SEASA) before and after two self-harm vignettes featuring named peers from the participant's social network (to simulate exposure to peer non-suicidal self-harm) and after a wash-out exposure. We used paired t-tests to compare mean SEASA scores pre- and post-exposure, and linear regression to test for an association between RPI and change in SEASA scores pre- and post-exposure.Results: Perceived ability to control urges to self-harm was significantly reduced following exposure to peer self-harm (t(96) = 4.02, p < 0.001, mean difference = 0.61; 95% CI = 0.31, 0.91), but was not significantly different from baseline after exposure to a wash-out. We found no association between suggestibility and change in urges to self-harm after exposure to peer self-harm.Conclusion: Our findings support social influences on self-harm in a sample of young adults, regardless of their individual degree of suggestibility.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-13"},"PeriodicalIF":3.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the effects of oxidative stress, inflammation on the pathway of tryptophan/kynurenine in OCD. 氧化应激、炎症对强迫症中色氨酸/犬尿氨酸通路影响的研究。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-11-28 DOI: 10.1017/neu.2023.55

Elif Delen, Cem Ismail Kucukali, Zerrin Karaaslan, Hande Yuceer, Seyma Punar, Mehmet Tolgahan Hakan, Ilhan Yaylim, Elif Ozkok

{"title":"Investigation of the effects of oxidative stress, inflammation on the pathway of tryptophan/kynurenine in OCD.","authors":"Elif Delen, Cem Ismail Kucukali, Zerrin Karaaslan, Hande Yuceer, Seyma Punar, Mehmet Tolgahan Hakan, Ilhan Yaylim, Elif Ozkok","doi":"10.1017/neu.2023.55","DOIUrl":"10.1017/neu.2023.55","url":null,"abstract":"Objectives: Recent studies have shown that the distribution of the tryptophan/kynurenine pathway (KP) plays a role in the development of obsessive-compulsive disorder (OCD). We aimed to reveal the relationship between CYP1A1 rs464903 and aryl hydrocarbon receptor (AhR) rs10249788 associated with the KP and interferon gamma (IFN γ) and oxidative stress in OCD.Methods: In our study, the serum and DNAs of 150 samples, including 100 OCD patients and 50 controls, were used. The activity of glutathione peroxidase (GSH-Px), and the levels of IFN γ, thiobarbituric acid reactive substances (TBARS), tryptophan, and kynurenine were determined by biochemical methods. AhR rs10249788 and cytochrome P450 family CYP1A1 rs4646903, which interact directly with the KP, were analysed by polymerase chain reaction followed by restriction fragment length polymorphism. P < 0.05 was considered statistically significant.Result: There were no significant differences between groups in CYP1A1 rs4646903 and AhR rs10249788 while tryptophan and IFN γ were found to be higher in controls (p < 0.001, for both), and TBARS and indolamine-2,3-dioxygenase were found to be higher in OCD (p < 0.001, for both). There were significant correlations between IFN γ and TBARS and GSH-Px (p = 0.028, p = 0.020, respectively) in the OCD group.Conclusions: For the first time studied in OCD, it has been shown that IFN γ, tryptophan, oxidative stress parameters, and gene variants of CYP1A1 rs4646903 anAhR rs10249788 are shown effective on the KP.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-11"},"PeriodicalIF":3.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138446734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor. 从抑郁中逃离:暴露于早期生活压力源的青春期FSL大鼠的产前和青春期前运动的抗抑郁样潜力。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-11-16 DOI: 10.1017/neu.2023.52

Ashleigh J Whitney, Zander Lindeque, Ruan Kruger, Stephan F Steyn

{"title":"Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor.","authors":"Ashleigh J Whitney, Zander Lindeque, Ruan Kruger, Stephan F Steyn","doi":"10.1017/neu.2023.52","DOIUrl":"10.1017/neu.2023.52","url":null,"abstract":"Objective: We aimed to answer the questions of whether early-life (perinatal and/or juvenile) exercise can induce antidepressant-like effects in a validated rodent model of depression, and whether such early-life intervention could prevent or reverse the adverse effects of early-life stress in their offspring.Methods: Male and female Flinders sensitive line rats born to a dam that exercised during gestation, or not, were either maternally separated between PND02 and 16 and weaned on PND17 or not. Half of these animals then underwent a fourteen-day low-intensity exercise regimen from PND22. Baseline depressive-like behaviour was assessed on PND21 and then reassessed on PND36, whereafter hippocampal monoamine levels, redox state markers and metabolic markers relevant to mitochondrial function were measured.Results: Pre-pubertal exercise was identified as the largest contributing factor to the observed effects, where it decreased immobility time in the FST by 6%, increased time spent in the open arms of the EPM by 9%. Hippocampal serotonin and norepinephrine levels were also increased by 35% and 26%, respectively, whilst nicotinic acid was significantly decreased.Conclusion: These findings suggest that pre-pubertal low-intensity exercise induces beneficial biological alterations that could translate into antidepressant behaviour in genetically susceptible individuals.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-15"},"PeriodicalIF":3.8,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood-brain barrier permeability and electroconvulsive therapy: a systematic review. 血脑屏障通透性与电休克治疗——系统综述。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-10-16 DOI: 10.1017/neu.2023.48

Christoffer C Lundsgaard, Krzysztof Gbyl, Poul Videbech

{"title":"Blood-brain barrier permeability and electroconvulsive therapy: a systematic review.","authors":"Christoffer C Lundsgaard, Krzysztof Gbyl, Poul Videbech","doi":"10.1017/neu.2023.48","DOIUrl":"10.1017/neu.2023.48","url":null,"abstract":"Objective: The cause of cognitive side effects after electroconvulsive therapy (ECT) is largely unknown. Alterations in the blood-brain barrier (BBB) have been considered in several recent ECT studies. We therefore found it worthwhile to perform a systematic review of the literature to examine if electrically induced seizures affect the permeability of the BBB.Methods: PubMed/MEDLINE and Embase were searched 16 November 2022. Studies with a direct measurement of BBB permeability in animals treated with modified electroconvulsive stimulation (ECS) and in humans treated with ECT were included. Synthesis of results was narrative due to the low number of studies and differences in study designs.Results: Four animal and two human (31 participants) studies were included. In animals, two studies found increased BBB permeability to some smaller molecules after modified ECS, while the two other studies found marginally increased or unchanged permeability to albumin after treatment. In contrast, the human studies did not find increased BBB permeability to smaller molecules or albumin after ECT.Conclusion: Animal but not human studies support increased BBB permeability to some smaller molecules after electrically induced seizures. However, this conclusion is confined by the low number of studies and the lack of studies applying state-of-the-art methods. More studies using modern approaches to measuring of BBB permeability are warranted.Funding and registration: The study was founded by Mental Health Services in the Capital Region of Denmark (grant number 61151-05) and was registered on PROSPERO before data extraction was initiated (CRD42022331385).","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-8"},"PeriodicalIF":3.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study. 代谢综合征在未经治疗的双相情感障碍中的发生：一项横断面研究。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-10-16 DOI: 10.1017/neu.2023.47

Qianli Liu, Lan Wang, Fengya Zhen, Cuixia An

{"title":"Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study.","authors":"Qianli Liu, Lan Wang, Fengya Zhen, Cuixia An","doi":"10.1017/neu.2023.47","DOIUrl":"10.1017/neu.2023.47","url":null,"abstract":"Objective: This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders.Methods: A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination centre of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, high-density lipoprotein-cholesterol, cholesterol, low-density lipoprotein-cholesterol, and fasting plasma glucose.Results: The incidence of metabolic syndrome in the bipolar disorders group was higher compared to the control group (9.6% VS. 8.5%). After calibrating sex and age data, a significant difference between the two groups was observed (P < 0.05). Diastolic and systolic blood pressure were higher in the bipolar disorders group compared to the control group (P < 0.01). Men with bipolar disorders had a higher risk of developing metabolic syndrome than women (14.5% vs. 5.8%). Bipolar disorders, sex, age, and BMI were identified as independent risk factors for metabolic syndrome. No significant difference was found in terms of metabolic index and incidence of metabolic syndrome between individuals with depressive episodes (n = 37) and manic episodes (n = 75).Conclusion: Patients with bipolar disorders were found to have a higher risk of developing metabolic syndrome than healthy individuals. Bipolar disorders, male sex, age, and BMI may contribute to an increased risk of developing metabolic syndrome.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-6"},"PeriodicalIF":3.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the complexity of COVID-19: a multifaceted examination. 驾驭新冠肺炎的复杂性：一个多方面的检查。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2023-10-01 Epub Date: 2023-11-10 DOI: 10.1017/neu.2023.50

Gregers Wegener

引用次数: 0

Systematic review of gene expression studies in people with Lewy body dementia. 路易体痴呆患者基因表达研究的系统综述。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-12-01 Epub Date: 2020-03-17 DOI: 10.1017/neu.2020.13

Anisa Chowdhury, Anto P Rajkumar

{"title":"Systematic review of gene expression studies in people with Lewy body dementia.","authors":"Anisa Chowdhury, Anto P Rajkumar","doi":"10.1017/neu.2020.13","DOIUrl":"https://doi.org/10.1017/neu.2020.13","url":null,"abstract":"Objectives: Lewy body dementia (LBD) is the second most prevalent neurodegenerative dementia and it causes more morbidity and mortality than Alzheimer's disease. Several genetic associations of LBD have been reported and their functional implications remain uncertain. Hence, we aimed to do a systematic review of all gene expression studies that investigated people with LBD for improving our understanding of LBD molecular pathology and for facilitating discovery of novel biomarkers and therapeutic targets for LBD.Methods: We systematically reviewed five online databases (PROSPERO protocol: CRD42017080647) and assessed the functional implications of all reported differentially expressed genes (DEGs) using Ingenuity Pathway Analyses.Results: We screened 3,809 articles and identified 31 eligible studies. In that, 1,242 statistically significant (p < 0.05) DEGs including 70 microRNAs have been reported in people with LBD. Expression levels of alternatively spliced transcripts of SNCA, SNCB, PRKN, APP, RELA, and ATXN2 significantly differ in LBD. Several mitochondrial genes and genes involved in ubiquitin proteasome system and autophagy-lysosomal pathway were significantly downregulated in LBD. Evidence supporting chronic neuroinflammation in LBD was inconsistent. Our functional analyses highlighted the importance of ribonucleic acid (RNA)-mediated gene silencing, neuregulin signalling, and neurotrophic factors in the molecular pathology of LBD.Conclusions: α-synuclein aggregation, mitochondrial dysfunction, defects in molecular networks clearing misfolded proteins, and RNA-mediated gene silencing contribute to neurodegeneration in LBD. Larger longitudinal transcriptomic studies investigating biological fluids of people living with LBD are needed for molecular subtyping and staging of LBD. Diagnostic biomarker potential and therapeutic promise of identified DEGs warrant further research.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 6","pages":"281-292"},"PeriodicalIF":3.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37742338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Monocyte count in schizophrenia and related disorders: a systematic review and meta-analysis. 单核细胞计数在精神分裂症和相关疾病中的作用:一项系统综述和荟萃分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-10-01 Epub Date: 2020-03-17 DOI: 10.1017/neu.2020.12

Mario Gennaro Mazza, Martina Capellazzi, Sara Lucchi, Ilaria Tagliabue, Aurora Rossetti, Massimo Clerici

{"title":"Monocyte count in schizophrenia and related disorders: a systematic review and meta-analysis.","authors":"Mario Gennaro Mazza, Martina Capellazzi, Sara Lucchi, Ilaria Tagliabue, Aurora Rossetti, Massimo Clerici","doi":"10.1017/neu.2020.12","DOIUrl":"https://doi.org/10.1017/neu.2020.12","url":null,"abstract":"Objective: Increasing evidence suggests that immunological and inflammatory dysfunctions may play an important role in predisposition, onset, and progression of schizophrenia and related psychosis. The activation of cells of the mononuclear phagocyte system, especially microglia and monocytes, has been reported in schizophrenia. We carried out this systematic review and meta-analysis to investigate if there are significant differences in monocyte count comparing healthy controls with people suffering from schizophrenia and related disorders.Methods: We searched main electronic databases; nine records met all our criteria and were included in the meta-analysis. Meta-analyses based on random effects models have been carried out generating pooled standardised mean differences (SMDs) of monocyte count in peripheral blood between schizophrenia and related psychosis and healthy controls. Heterogeneity was estimated. Relevant sensitivity and subgroup analyses were conducted.Results: Patients showed higher monocyte count as compared with healthy control (SMD = 0.393; p = 0.001). Heterogeneity across studies was from moderate to high (I2 = 65.952%); sensitivity analysis leaving out two studies responsible for most of the heterogeneity showed a slightly higher SMD. Subgroup analyses confirmed this result, showing no significant differences in the effect size across different study characteristics.Conclusions: Monocyte count can be considered an indirect marker of microglia activation in the central nervous system. Thus, the observed higher monocyte count in patients could be considered as a possible peripheral marker of microglia's activation in schizophrenia disorder.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 5","pages":"229-236"},"PeriodicalIF":3.8,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.12","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37742340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

How to increase the role of social workers in suicide preventive interventions. 如何提高社会工作者在自杀预防干预中的作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-03-16 DOI: 10.1017/neu.2020.11

Joshua Levine, Leo Sher

{"title":"How to increase the role of social workers in suicide preventive interventions.","authors":"Joshua Levine, Leo Sher","doi":"10.1017/neu.2020.11","DOIUrl":"https://doi.org/10.1017/neu.2020.11","url":null,"abstract":"Objective: Suicide is a serious public health issue that affects individuals, families and societies all over the world. International studies provide consistent evidence that the presence of psychiatrists in a region is associated with lesser suicide rates. However, many psychiatric patients including suicidal patients do not have access to psychiatrists. This indicates that mental health and non-mental health social workers need to be involved in suicide prevention efforts. This paper is the first comprehensive work that discusses how to increase the role of social workers in the area of suicide prevention.Methods: A review of the relevant literature.Results: Increasing the role of social workers in suicide prevention efforts may reduce suicide risk in groups and people at elevated risk for suicide, as well as the general population.Conclusion: Recommendations are provided for how the social work profession can improve upon suicide prevention while incorporating universal, selective and indicated suicide preventive interventions. Social work research efforts should focus on how to increase the role of social workers in suicide prevention and the management of suicidal patients. Social work education programmes should modify their curricula and increase their attention on suicide prevention. Mental health social workers need to educate the patient and their family on suicide risk factors. Furthermore, mental health and non-mental health social workers need to educate the general public on suicide risk factors.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 4","pages":"186-195"},"PeriodicalIF":3.8,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37739089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The depressive state of Denmark during the COVID-19 pandemic. COVID-19大流行期间丹麦的抑郁状态。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-04-22 DOI: 10.1017/neu.2020.15

Kim Mannemar Sønderskov, Peter Thisted Dinesen, Ziggi Ivan Santini, Søren Dinesen Østergaard

引用次数: 252