Investigation of the relationship of sleep disorder occurring in fibromyalgia with central nervous system and pineal gland volume.

IF 2.6 4区医学 Q3 NEUROSCIENCES

Acta Neuropsychiatrica Pub Date : 2024-11-11 DOI:10.1017/neu.2024.49

Fatih Çiçek, İlyas Uçar, Turgut Seber, Fatma Gül Ülkü Demir, Ali Türker Çiftçi

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引用次数: 0

Abstract

Objective: Mechanisms of sleep disorders in fibromyalgia (FM) patients, such as insomnia, early morning awakenings and poor quality sleep, have not yet been proven and no consistent and effective treatment is yet available. The aim of this study was to investigate the pineal gland volume and the relationship between total fibre count, total fibre volume and total fibre length of the spinoreticular tract involved in regulation of sleep and wakefulness in terms of the mechanism of sleep disturbance.

Methods: This study included only female cases, 31 with fibromyalgia and 31 controls. Pittsburgh Sleep Quality Index was used to assess sleep quality. Tractography of targeted pathway from brain diffusion MR images was calculated in Diffusion Studio Imaging (DSI) Studio programme and the volume of the pineal gland was calculated in ITK-SNAP programme.

Results: The mean volume of the pineal gland was higher in control group (218.84 ± 64.45 mm³) than in fibromyalgia group (174.77 ± 48.65 mm³), which was statistically significant (p = 0.004). However, there was no statistically significant difference between two groups in total spinoreticular tract (TSRT), total volume (TSRTV), TSRT fractional anisotropy, TSRT mean diffusion, TSRT axial diffusion and TSRT radial diffusion of spinoreticular tract, which is involved in the regulation of sleep and wakefulness (p > 0.05).

Conclusion: In conclusion, it is thought that the endocrine system may be more related to sleep disturbance in individuals with FM than central nervous system. Therefore, we believe that it may be more appropriate to work on the endocrine system rather than neural system in the treatment of sleep disturbance in patients with FM.

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纤维肌痛患者睡眠障碍与中枢神经系统和松果体体积的关系研究

目的：纤维肌痛（FM）患者失眠、早醒和睡眠质量差等睡眠障碍的机制尚未得到证实，也没有一致有效的治疗方法。本研究旨在从睡眠障碍的机制角度，研究松果体体积以及参与调节睡眠和觉醒的脊髓束总纤维数、总纤维体积和总纤维长度之间的关系：本研究仅包括女性病例，31 名纤维肌痛患者和 31 名对照组患者。采用匹兹堡睡眠质量指数（PSQI）评估睡眠质量。用 DSI Studio 程序计算脑弥散 MR 图像中目标通路的迹线，用 ITK-SNAP 程序计算松果体的体积：结果：对照组松果体的平均体积（218.84±64.45 mm3）高于纤维肌痛组（174.77±48.65 mm3），差异有统计学意义（P=0.004）。然而，两组在参与调节睡眠和觉醒的脊髓束总脊髓束（TSRT）、总体积（TSRTV）、TSRT FA、TSRT MD、TSRT AD和TSRT RD方面差异无统计学意义（P>0.05）：总之，与中枢神经系统相比，人们认为内分泌系统可能与调频患者的睡眠障碍关系更大。因此，我们认为在治疗 FM 患者的睡眠障碍时，从内分泌系统入手可能比从神经系统入手更合适。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY

自引率

5.30%

发文量

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.