Acta Neuropsychiatrica最新文献

Interplay of combat deployment harassment, testosterone concentrations and post-deployment suicide risk in male veterans. 作战部署骚扰、睾酮浓度与男性退伍军人部署后自杀风险的相互作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-03-26 DOI: 10.1017/neu.2024.12

Leo Sher, Linda M Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda

{"title":"Interplay of combat deployment harassment, testosterone concentrations and post-deployment suicide risk in male veterans.","authors":"Leo Sher, Linda M Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda","doi":"10.1017/neu.2024.12","DOIUrl":"10.1017/neu.2024.12","url":null,"abstract":"Objective: Many combat veterans exhibit suicidal ideation and behaviour, but the relationships among experiences occurring during combat deployment and suicidality are still not fully understood. In this study, we tested the hypothesis that harassment during a combat deployment is associated with post-deployment suicidality and testosterone function.Methods: Male combat veterans who made post-deployment suicide attempts and demographically matched veterans without a history of suicide attempts were enrolled in the study. Demographic and clinical parameters of study participants were assessed and recorded. Study participants were interviewed by a trained clinician using the Mini-International Neuropsychiatric Interview (MINI), the Deployment Risk and Resilience Inventory (DRRI) – Relationships within unit scale, the Scale for Suicidal Ideation (SSI), and the Brown–Goodwin Aggression Scale. Free testosterone levels were assessed in morning blood samples.Results: DRRI harassment scores were higher and free testosterone levels were lower among suicide attempters in comparison with non-attempters. In the whole sample, DRRI harassment scores positively correlated with SSI scores and negatively correlated with free testosterone levels. Free testosterone levels negatively correlated with SSI scores. Aggression scale scores positively correlated with DRRI harassment scores among non-attempters but not among attempters.Conclusion: Our observations that harassment scores are associated with suicidality and testosterone levels, and suicidality is associated with testosterone levels may indicate that there is a link between deployment harassment, testosterone function and suicidality.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderating effects of diagnosis and gender on the influence of age on electroconvulsive therapy outcome. 诊断和性别对年龄影响电休克疗法结果的调节作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-01-31 DOI: 10.1017/neu.2024.4

Eduardo Tedeschi, Mauricio S Hoffmann, Pedro V S Magalhães

引用次数: 0

Bradykinin actions in the central nervous system: historical overview and psychiatric implications. 中枢神经系统中的缓激肽作用：历史概述和对精神病学的影响。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI: 10.1017/neu.2023.57

Frederico Guilherme Graeff, Sâmia Joca, Helio Zangrossi

引用次数: 0

Dysfunction of circulating endothelial progenitor cells in major depressive disorder. 重度抑郁症患者循环内皮祖细胞的功能障碍

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-01-05 DOI: 10.1017/neu.2023.49

Ying-Jay Liou, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Po-Hsun Huang, Ya-Mei Bai

{"title":"Dysfunction of circulating endothelial progenitor cells in major depressive disorder.","authors":"Ying-Jay Liou, Mu-Hong Chen, Ju-Wei Hsu, Kai-Lin Huang, Po-Hsun Huang, Ya-Mei Bai","doi":"10.1017/neu.2023.49","DOIUrl":"10.1017/neu.2023.49","url":null,"abstract":"Objectives: Despite mounting evidence demonstrates circulating endothelial progenitor cells (cEPCs) quantitative changes in depression, no study has investigated cEPC functions in major depressive disorder (MDD). We investigated the role of cEPC adhesive and apoptotic functions in MDD.Methods: We recruited 68 patients with MDD and 56 healthy controls (HCs). The depression symptoms, anxiety, psychosomatic symptoms, subjective cognitive dysfunction, quality of life, and functional disability were evaluated using the Hamilton Depression Rating Scale and Montgomery-Åsberg Depression Rating Scale, Hamilton Anxiety Rating Scale, Depression and Somatic Symptoms Scale (DSSS), Perceived Deficits Questionnaire-Depression, 12-Item Short Form Health Survey (SF-12), and Sheehan Disability Scale (SDS), respectively. Working memory and executive function were assessed using a 2-back task and Wisconsin Card Sorting Test (WCST). Inflammatory marker (soluble interleukin-6 receptor, C-reactive protein, and tumor necrosis factor-α receptor-1), cEPC adhesive, and apoptotic levels were measured using in vitro assays.Results: The MDD patients showed significantly lower cEPC adhesive levels than the HCs, and this difference in adhesive function remained statistically significant even after adjusting for inflammatory marker levels. The cEPC adhesion levels were in inverse correlations with commission and omission errors in 2-back task, the percent perseverative response and percent perseverative errors in WCST, and the DSSS and SDS scores, but in positive correlations with SF-12 physical and mental component scores. cEPC apoptotic levels did not differ significantly between the groups.Conclusion: The findings indicate that cEPC adhesive function is diminished in MDD and impacts various aspects of cognitive and psychosocial functions associated with the disorder.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Missed conceptions about paediatric bipolar disorder: a reply and discussion of DMDD. 关于儿童双相情感障碍的误解：对 DMDD 的答复和讨论。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1017/neu.2024.11

Gin S Malhi, Erica Bell

引用次数: 0

On hallucinations and memory: the relationship between hallucinations and autobiographical overgenerality in Alzheimer's Disease. 幻觉与记忆：阿尔茨海默氏症患者的幻觉与自传体过度泛化之间的关系。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-06-01 Epub Date: 2024-02-19 DOI: 10.1017/neu.2024.7

Mohamad El Haj, Frank Larøi

引用次数: 0

Addressing the Neurodevelopmental Impacts of Prenatal Substance Exposure: Insights from a Taiwanese Study on Methadone Maintenance Treatment During Pregnancy. 应对产前药物接触对神经发育的影响：台湾一项关于孕期美沙酮维持治疗的研究的启示。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-05-31 DOI: 10.1017/neu.2024.24

Lien-Chung Wei, Hsien-Jane Chiu

引用次数: 0

The Impact of Morningness-Eveningness on Depression through a Serial Mediation Model of Resilience and Anxiety. 通过复原力和焦虑的串联调解模型研究 "早睡早起 "对抑郁症的影响

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-05-27 DOI: 10.1017/neu.2024.23

Suhyeon Kang, Huiyeong Kim, Hyeona Yu, Daseul Lee, Hyuk Joon Lee, Tae Hyon Ha, Jungkyu Park, Woojae Myung, Hyo Shin Kang

{"title":"The Impact of Morningness-Eveningness on Depression through a Serial Mediation Model of Resilience and Anxiety.","authors":"Suhyeon Kang, Huiyeong Kim, Hyeona Yu, Daseul Lee, Hyuk Joon Lee, Tae Hyon Ha, Jungkyu Park, Woojae Myung, Hyo Shin Kang","doi":"10.1017/neu.2024.23","DOIUrl":"https://doi.org/10.1017/neu.2024.23","url":null,"abstract":"Objective: Resilience has been recently considered one of the possible mechanisms for the association between morningness-eveningness and depression. Meanwhile, anxiety is closely associated with mood disorder, but its association with morningness-eveningness is unclear. Therefore, this study aimed to explore the mediating effects of resilience and anxiety on morningness-eveningness and depression as the possible mechanisms.Methods: This study included patient group and nonpatient group. Patient group consists of 743 patients with mood disorders [Major Depressive Disorder (MDD), 233; Bipolar Disorder Ⅰ (BDⅠ), 113; Bipolar Disorder Ⅱ (BDⅡ), 397] whereas nonpatient group consists of 818 individuals without mood disorder. The Composite Scale of Morningness, Connor-Davidson Resilience Scale, Self-Rating Depression Scale, and Beck Anxiety Inventory were used to evaluate morningness-eveningness, resilience, anxiety, and depression, respectively.Results: Our model provided a good fit for the data. The association between morningness-eveningness and depression symptoms was partially serially mediated by resilience and anxiety in both the patient and nonpatient groups. The patient group exhibited significantly stronger morningness-eveningness toward resilience and anxiety than the nonpatient group. In the indirect effect of morningness-eveningness on depression, group differences exist only through each mediation of resilience and anxiety, not through serial mediation.Conclusion: Our results expand on the mechanism underlying the association between morningness-eveningness and depression. They highlight the importance of morningness-eveningness modification to increase resilience and the need to consider anxiety jointly in this process.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol improves nonmotor symptoms, attenuates neuroinflammation and favors hippocampal newborn neuronal maturation in a rat model of Parkinsonism. 在帕金森病大鼠模型中，大麻二酚可改善非运动症状、减轻神经炎症并促进海马新生神经元成熟。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-05-21 DOI: 10.1017/neu.2024.15

Bianca Andretto de Mattos, Jéssica Mendes Bonato, Maria Clara Splendor, Elaine Del Bel, Humberto Milani, Rúbia Maria Weffort de Oliveira

{"title":"Cannabidiol improves nonmotor symptoms, attenuates neuroinflammation and favors hippocampal newborn neuronal maturation in a rat model of Parkinsonism.","authors":"Bianca Andretto de Mattos, Jéssica Mendes Bonato, Maria Clara Splendor, Elaine Del Bel, Humberto Milani, Rúbia Maria Weffort de Oliveira","doi":"10.1017/neu.2024.15","DOIUrl":"https://doi.org/10.1017/neu.2024.15","url":null,"abstract":"Objective: To investigate the effects of cannabidiol (CBD) on emotional and cognitive symptoms in rats with intra-nigral 6-hydroxydopamine (6-OHDA) lesions.Methods: Adult male Wistar rats received bilateral intranigral 6-OHDA infusions and were tested in a battery of behavioral paradigms to evaluate nonmotor symptoms. The brains were obtained to evaluate the effects of CBD on hippocampal neurogenesis.Results: 6-hydroxydopamine-lesioned rats exhibited memory impairments and despair-like behavior in the novelty-suppressed feeding test and forced swim test, respectively. The animals also exhibited dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc), striatum, and ventral tegmental area and a reduction of hippocampal neurogenesis. Cannabidiol decreased dopaminergic neuronal loss in the SNpc, reduced the mortality rate and decreased neuroinflammation in 6-OHDA-lesioned rats. In parallel, CBD prevented memory impairments and attenuated despair-like behavior that were induced by bilateral intranigral 6-OHDA lesions. Repeated treatment with CBD favored the neuronal maturation of newborn neurons in the hippocampus in Parkinsonian rats.Conclusion: The present findings suggest a potential beneficial effect of CBD on nonmotor symptoms induced by intra-nigral 6-OHDA infusion in rats.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the complex tapestry of addiction: insights from recent research. 揭开成瘾的复杂面纱：最新研究的启示。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI: 10.1017/neu.2024.8

Gregers Wegener

引用次数: 0