Acta Neuropsychiatrica最新文献_第7页

Exploring the intersection of metabolic and neuropsychiatric health. 探索代谢和神经精神健康的交叉点。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1017/neu.2024.59

Rodrigo Grassi-Oliveira

引用次数: 0

Network meta-analysis of the effectiveness of psychotherapies with or without medication for treating adult depression. 对有无药物治疗成人抑郁症的心理疗法效果进行网络荟萃分析。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1017/neu.2024.45

Mayumi Fukumori, Toshiaki Kikuchi, Yi Zhou, Satoshi Hattori, Takashi Kudo

{"title":"Network meta-analysis of the effectiveness of psychotherapies with or without medication for treating adult depression.","authors":"Mayumi Fukumori, Toshiaki Kikuchi, Yi Zhou, Satoshi Hattori, Takashi Kudo","doi":"10.1017/neu.2024.45","DOIUrl":"10.1017/neu.2024.45","url":null,"abstract":"Objective: To ascertain whether psychotherapies combined with medication are more efficacious than those without medication and determine which combinations yield the best results.Methods: We conducted a network meta-analysis of randomised controlled trials (RCTs) comparing behavioural activation (BA), psychoanalytic/psychodynamic psychotherapy (DYN), interpersonal psychotherapy (IPT), individual face-to-face cognitive behavioural therapy (CBT (ftf)), group cognitive behavioural therapy (gCBT), and computerised or internet cognitive behavioural therapy (iCBT) with each other, or with treatment-as-usual (TAU) and wait list control (WLC) among adults formally diagnosed with depression. The psychotherapy arms were categorised as either psychotherapy alone or psychotherapy combined with medication (+ p). Treatment efficacy was assessed based on depression severity. We used a random-effects model to conduct a pairwise meta-analysis.Results: A total of 100 RCTs with 9,873 participants were included. The most common treatment was CBT (ftf) alone. All treatment arms were compared with TAU. Most psychotherapies combined with medication were superior to psychotherapy alone. In the subgroup analyses according to the baseline severity of depression, most psychotherapies combined with medication were more effective than psychotherapy alone in moderate-to-severe depression, whereas in mild depression, such differences were not observed. Among psychotherapies with medication, gCBT + p was significantly more effective than TAU and other psychotherapies in both the main and subgroup analyses.Conclusion: The efficacy of depression treatment varied depending on the severity of the depressive condition. Notably, gCBT + p was identified as the most effective approach for treating adult depression.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"423-437"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attention improvement to transcranial alternating current stimulation at gamma frequency over the right frontoparietal network: a preliminary report. 经颅交变电流γ频率刺激右侧顶叶网络可改善注意力：初步报告。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1017/neu.2024.35

Tien-Wen Lee, Sergio Almeida, Gerald Tramontano

{"title":"Attention improvement to transcranial alternating current stimulation at gamma frequency over the right frontoparietal network: a preliminary report.","authors":"Tien-Wen Lee, Sergio Almeida, Gerald Tramontano","doi":"10.1017/neu.2024.35","DOIUrl":"10.1017/neu.2024.35","url":null,"abstract":"Applying transcranial alternating current stimulation (tACS) at 40 Hz to the frontal and parietal regions, either unilaterally (left or right) or bilaterally, can improve cognitive dysfunctions. This study aimed to explore the influence of tACS at gamma frequency over right fronto-parietal (FP) region on attention. The analysis is based on retrospective data from a clinical intervention. We administered test of variables of attention (TOVA; visual mode) to 44 participants with various neuropsychiatric diagnoses before and after 12 sessions of tACS treatment. Alternating currents at 2.0 mA were delivered to the electrode positions F4 and P4, following the 10-20 EEG convention, for 20 mins in each session. We observed significant improvement across 3 indices of the TOVA, including reduction of variability in reaction time (p = 0.0002), increase in d-Prime (separability of targets and non-targets; p = 0.0157), and decrease in commission error rate (p = 0.0116). The mean RT and omission error rate largely remained unchanged. Artificial injection of tACS at 40 Hz over right FP network may improve attention function, especially in the domains of consistency in performance, target/non-target discrimination, and inhibitory control.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"495-499"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing psychiatric nosology through philosophical inquiry. 通过哲学探究推进精神病命名学。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1017/neu.2024.21

Shokouh Arjmand, Reza Saboori Amleshi, Francisco S Guimarães, Gregers Wegener

引用次数: 0

Relationship between early traumatic experiences and emotional regulation skills in major depressive and bipolar disorders. 重度抑郁症和双相情感障碍患者的早期创伤经历与情绪调节能力之间的关系。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1017/neu.2024.41

Yejin Park, Chan Woo Lee, Yoonjeong Jang, Sarah Soonji Kwon, Hyeona Yu, Joohyun Yoon, Yun Seong Park, Hyun A Ryoo, Junwoo Jang, Hyuk Joon Lee, Yeong Chan Lee, Hong-Hee Won, Tae Hyon Ha, Woojae Myung

{"title":"Relationship between early traumatic experiences and emotional regulation skills in major depressive and bipolar disorders.","authors":"Yejin Park, Chan Woo Lee, Yoonjeong Jang, Sarah Soonji Kwon, Hyeona Yu, Joohyun Yoon, Yun Seong Park, Hyun A Ryoo, Junwoo Jang, Hyuk Joon Lee, Yeong Chan Lee, Hong-Hee Won, Tae Hyon Ha, Woojae Myung","doi":"10.1017/neu.2024.41","DOIUrl":"10.1017/neu.2024.41","url":null,"abstract":"Childhood trauma can cause deficits in emotional regulation. However, few studies have investigated childhood trauma and emotional regulation skills in patients with mood disorders. We aimed to investigate how childhood trauma and Emotion Regulation Skills Questionnaire (ERSQ) scores are associated with mood disorders.This study included 779 patients with mood disorders (major depressive disorder [MDD, n = 240], bipolar I disorder [BDI, n = 121], and bipolar II disorder [BDII, n = 418]). We used their Childhood Trauma Questionnaire-Short Form (CTQ) and ERSQ scores for the evaluation.The between-group differences in CTQ and ERSQ scores were examined. The CTQ and ERSQ total scores were negatively correlated. Among the CTQ subscales, emotional neglect showed a significant correlation with the ERSQ total score, whereas acceptance and tolerance showed higher negative correlations with the CTQ than with the other ERSQ subscales. The negative relationship between emotional regulation and childhood trauma varied significantly depending on the group, with the BDI group showing a more prominent association than the other groups.Based on various mood disorders, we observed associations between childhood trauma and emotional regulation skills. Consequently, our study offers notable insights for future research on the impact of childhood trauma on ERSQ.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"476-484"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A meta-analysis of the prevalence of neuropsychiatric disorders and their association with disease onset in myotonic dystrophy. 肌营养不良症神经精神障碍发病率及其与发病关系的荟萃分析。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1017/neu.2024.27

Carlos Pascual-Morena, Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Celia Álvarez-Bueno, Maribel Lucerón-Lucas-Torres, Alicia Saz-Lara, Irene Martínez-García

{"title":"A meta-analysis of the prevalence of neuropsychiatric disorders and their association with disease onset in myotonic dystrophy.","authors":"Carlos Pascual-Morena, Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Celia Álvarez-Bueno, Maribel Lucerón-Lucas-Torres, Alicia Saz-Lara, Irene Martínez-García","doi":"10.1017/neu.2024.27","DOIUrl":"10.1017/neu.2024.27","url":null,"abstract":"There is a high prevalence of neuropsychiatric disorders in myotonic dystrophy types 1 and 2 (DM1 and DM2), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in DM1, and depression and anxiety in both DMs. The aim of this systematic review and meta-analysis was to estimate the prevalence of ASD, ADHD, depression and anxiety in the population with DM, and their association with disease onset. A systematic search of Medline, Scopus, Web of Science, and the Cochrane Library was conducted from inception to November 2023. Observational studies estimating the prevalence of these disorders in DM1 or DM2 were included. A meta-analysis of the prevalence of these disorders and an association study with disease onset by prevalence ratio meta-analysis were performed. Thirty-eight studies were included. In DM1, the prevalence of ASD was 14%, with congenital onset being 79% more common than juvenile onset, while the prevalence of ADHD was 21%, with no difference between congenital and juvenile onset, and the prevalence of depression and anxiety were 14% and 16%. Depression was more common in the adult onset. Finally, the prevalence of depression in DM2 was 16%. A higher prevalence of neuropsychiatric disorders is observed in individuals with DM1 and DM2 than in the general population. Therefore, actively screening for congenital and juvenile neurodevelopmental disorders in DM1 and emotional disorders in DM1 and DM2 may improve the quality of life of those affected.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"390-401"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study. 代谢综合征在未经治疗的双相情感障碍中的发生：一项横断面研究。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2023-10-16 DOI: 10.1017/neu.2023.47

Qianli Liu, Lan Wang, Fengya Zhen, Cuixia An

{"title":"Occurrence of metabolic syndrome in untreated bipolar disorders: a cross-sectional study.","authors":"Qianli Liu, Lan Wang, Fengya Zhen, Cuixia An","doi":"10.1017/neu.2023.47","DOIUrl":"10.1017/neu.2023.47","url":null,"abstract":"Objective: This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders.Methods: A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination centre of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, high-density lipoprotein-cholesterol, cholesterol, low-density lipoprotein-cholesterol, and fasting plasma glucose.Results: The incidence of metabolic syndrome in the bipolar disorders group was higher compared to the control group (9.6% VS. 8.5%). After calibrating sex and age data, a significant difference between the two groups was observed (P < 0.05). Diastolic and systolic blood pressure were higher in the bipolar disorders group compared to the control group (P < 0.01). Men with bipolar disorders had a higher risk of developing metabolic syndrome than women (14.5% vs. 5.8%). Bipolar disorders, sex, age, and BMI were identified as independent risk factors for metabolic syndrome. No significant difference was found in terms of metabolic index and incidence of metabolic syndrome between individuals with depressive episodes (n = 37) and manic episodes (n = 75).Conclusion: Patients with bipolar disorders were found to have a higher risk of developing metabolic syndrome than healthy individuals. Bipolar disorders, male sex, age, and BMI may contribute to an increased risk of developing metabolic syndrome.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"357-362"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41240134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

International trends in male youth suicide and suicidal behaviour. 男性青年自杀和自杀行为的国际趋势。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-14 DOI: 10.1017/neu.2024.37

Timothy Rice, Anton Livshin, Zoltan Rihmer, Andreas Walther, Mohammed Bhuiyan, Adriana Bruges Boude, Ying-Yeh Chen, Xenia Gonda, Aliza Grossberg, Yonis Hassan, Ezequiel Lafont, Gianluca Serafini, Arthi Vickneswaramoorthy, Salonee Shah, Leo Sher

{"title":"International trends in male youth suicide and suicidal behaviour.","authors":"Timothy Rice, Anton Livshin, Zoltan Rihmer, Andreas Walther, Mohammed Bhuiyan, Adriana Bruges Boude, Ying-Yeh Chen, Xenia Gonda, Aliza Grossberg, Yonis Hassan, Ezequiel Lafont, Gianluca Serafini, Arthi Vickneswaramoorthy, Salonee Shah, Leo Sher","doi":"10.1017/neu.2024.37","DOIUrl":"10.1017/neu.2024.37","url":null,"abstract":"Objective: Suicide and suicidal behaviour strongly contribute to overall male youth mortality. An understanding of worldwide data contextualises suicide and suicidal behaviour in young men within any given country.Method: Members and colleagues of the World Federation of Societies of Biological Psychiatry's Task Force on Men's Mental Health review the relevant data from several regions of the world. The review identifies notable findings across regions of relevance to researchers, policymakers, and clinicians.Results: Male suicide and suicidal behaviour in adolescence and emerging adulthood within North America, Latin America and the Caribbean, Europe, the Mediterranean and the Middle East, Continental Africa, South Asia, East Asia, China, and Oceania share similarities as well as significant points of divergence.Conclusions: International data provide an opportunity to obtain a superior understanding of suicide and suicidal behaviour amongst young men.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"402-422"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor. 从抑郁中逃离:暴露于早期生活压力源的青春期FSL大鼠的产前和青春期前运动的抗抑郁样潜力。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2023-11-16 DOI: 10.1017/neu.2023.52

Ashleigh J Whitney, Zander Lindeque, Ruan Kruger, Stephan F Steyn

{"title":"Running from depression: the antidepressant-like potential of prenatal and pre-pubertal exercise in adolescent FSL rats exposed to an early-life stressor.","authors":"Ashleigh J Whitney, Zander Lindeque, Ruan Kruger, Stephan F Steyn","doi":"10.1017/neu.2023.52","DOIUrl":"10.1017/neu.2023.52","url":null,"abstract":"Objective: We aimed to answer the questions of whether early-life (perinatal and/or juvenile) exercise can induce antidepressant-like effects in a validated rodent model of depression, and whether such early-life intervention could prevent or reverse the adverse effects of early-life stress in their offspring.Methods: Male and female Flinders sensitive line rats born to a dam that exercised during gestation, or not, were either maternally separated between PND02 and 16 and weaned on PND17 or not. Half of these animals then underwent a fourteen-day low-intensity exercise regimen from PND22. Baseline depressive-like behaviour was assessed on PND21 and then reassessed on PND36, whereafter hippocampal monoamine levels, redox state markers and metabolic markers relevant to mitochondrial function were measured.Results: Pre-pubertal exercise was identified as the largest contributing factor to the observed effects, where it decreased immobility time in the FST by 6%, increased time spent in the open arms of the EPM by 9%. Hippocampal serotonin and norepinephrine levels were also increased by 35% and 26%, respectively, whilst nicotinic acid was significantly decreased.Conclusion: These findings suggest that pre-pubertal low-intensity exercise induces beneficial biological alterations that could translate into antidepressant behaviour in genetically susceptible individuals.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"363-377"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134650255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling. 水杨甙通过SIRT1/PGC-1α信号促进成人海马神经发生，从而发挥类似抗抑郁的作用。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1017/neu.2024.28

Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu

{"title":"Salidroside exerts antidepressant-like action by promoting adult hippocampal neurogenesis through SIRT1/PGC-1α signalling.","authors":"Shan Xing, Shuyi Xu, Linjiao Wang, Liyuan Guo, Xin Zhou, Haoxin Wu, Wei Wang, Lanying Liu","doi":"10.1017/neu.2024.28","DOIUrl":"10.1017/neu.2024.28","url":null,"abstract":"Depression is one of the major mental disorders, which seriously endangers human health, brings a serious burden to patients’ families. In this study, we intended to further explore the antidepressant-like effect and possible molecular mechanisms of Salidroside (SAL). We built corticosterone (CORT)-induced depressive mice model and used behavioural tests to evaluate depression behaviour. To explore the molecular mechanisms of SAL, we employed a variety of methods such as immunofluorescence, western blot, pharmacological interference, etc. The results demonstrated that SAL both at 25 mg/kg and 50 mg/kg can reduce immobility time in the tail suspension test (TST). At the same time, SAL treatment could restore the reduced sugar water intake preference in the sucrose preference test (SPT) in CORT-induced depressive mice and reduce the immobility time in TST and forced swimming experiments (FST). In addition, SAL treatment reversed the reduction in the number of Ki-67, BrdU, and NeuN in the hippocampus due to CORT treatment. SAL treatment also restored the expression of SIRT1, PGC-1α, brain-derived neurotrophic factor (BDNF) and other proteins in the hippocampus. In addition, after blocking SIRT1 signalling with EX527, we found that the treatment with SAL failed to reduce the immobility time in TST and FST, the level of SIRT1 and PGC-1α activity were correspondingly downregulated, and the expression of DCX and Ki-67 in the hippocampus failed to be activated. These findings suggested that SAL exerts antidepressant-like effects by promoting hippocampal neurogenesis through the SIRT1/PGC-1α signalling pathway.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"446-456"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0