Acta Neuropsychiatrica最新文献_第6页

Ultrasonic vocalisations in the Flinders Sensitive Line rat, a genetic animal model of depression. 弗林德斯敏感系大鼠的超声波发声，这是一种抑郁症的遗传动物模型。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2025-01-23 DOI: 10.1017/neu.2024.61

Linda Marie Kai, Lia Parada Iglesias, Kadri Kõiv, Jaanus Harro, Gregers Wegener

{"title":"Ultrasonic vocalisations in the Flinders Sensitive Line rat, a genetic animal model of depression.","authors":"Linda Marie Kai, Lia Parada Iglesias, Kadri Kõiv, Jaanus Harro, Gregers Wegener","doi":"10.1017/neu.2024.61","DOIUrl":"10.1017/neu.2024.61","url":null,"abstract":"Objective: Ultrasonic vocalisations (USVs) emitted by rats may reflect affective states. Specifically, 50 kHz calls emitted during juvenile playing are associated with positive affect. Given that depression is characterised by profound alterations in this domain, we proposed that USV calls may configure a suitable tool for assessing depressive-like states. Utilising the Flinders Sensitive Line (FSL), a well-established animal model of depression, we assessed USV calls emitted by rats during tickling, a procedure based on juvenile rats' rough-and-tumble play.Methods: Juvenile FSL rats and their control counterparts, the Flinders Resistant Line (FRL) and Sprague Dawley, were submitted to tickling sessions to imitate rats playing behaviour. The rats were tickled daily for 6 weeks starting at PND21. Tickling sessions were recorded for further acoustic analysis of 50 kHz calls.Results: Tickling increased 50 kHz calls in all the strains. FSL rats emitted more calls than control strains and exhibited a higher number of flat-trill combination calls.Conclusion: Tickling is a robust method for inducing 50 kHz USV calls. Analysing USV calls emitted during tickling configurates a suitable method for studying affective states relevant to depression. FSL rats did not present anhedonia but rather higher reward sensitivity, which may underlie their stress vulnerability.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"37 ","pages":"e3"},"PeriodicalIF":2.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acta Neuropsychiatrica embraces full open access: towards a new era of global knowledge sharing. 《神经精神病学学报》拥抱完全开放：迈向全球知识共享的新时代。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2025-01-21 DOI: 10.1017/neu.2024.66

Livea Dornela Godoy, Gregers Wegener

引用次数: 0

Impaired folate status in patients with mental disorders. 精神障碍患者叶酸状态受损。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2025-01-20 DOI: 10.1017/neu.2025.1

Narvini Rajen, Hanne Wrengler Velure, Erik Johnsen, Anne-Lise Bjørke-Monsen

{"title":"Impaired folate status in patients with mental disorders.","authors":"Narvini Rajen, Hanne Wrengler Velure, Erik Johnsen, Anne-Lise Bjørke-Monsen","doi":"10.1017/neu.2025.1","DOIUrl":"10.1017/neu.2025.1","url":null,"abstract":"Objective: Folate and cobalamin deficiency or impaired function due to genetic variants in key enzymes have been associated with neuropsychiatric symptoms. The aim of this study was to compare folate and cobalamin status in patients admitted to an acute psychiatric unit to patients from primary health care in order to reveal factors which may be important in the follow-up of patients with mental disorders.Methods: Anonymous blood samples tested for folate, cobalamin, the metabolic marker total homocysteine (tHcy), creatinine and glomerular filtration rate as well as age and gender in patients admitted to a psychiatric acute unit (n = 981) and patients from primary health care (controls) (n = 32,201) were reviewed retrospectively.Results: Median serum folate was 18% lower and median serum cobalamin was 11% higher in patients with mental disorders compared to controls. Folate deficiency was associated with 54% higher median tHcy levels among patients with mental disorders compared to controls. The prevalence of folate deficiency was 31% and of cobalamin deficiency 6% in patients admitted to a psychiatric acute unit in a Norwegian hospital in 2024.Conclusion: Folate, but not cobalamin deficiency, was prevalent in Norwegian patients with mental disorders. The higher tHcy levels in folate-deficient patients with mental disorders indicate an impaired folate metabolism, which might be related to genetic factors, such as polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. Ensuring a serum folate concentration above 15 nmol/L and a serum cobalamin above 250 pmol/L might improve symptoms in patients with mental disorders.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"e11"},"PeriodicalIF":2.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143014165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of azelaic acid on AlCl₃-induced neurocognitive impairments and molecular changes in the hippocampus of rats. 壬二酸对alcl3诱导大鼠神经认知功能障碍及海马组织分子变化的影响。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-17 DOI: 10.1017/neu.2024.55

Saba Vasegh, Hakimeh Saadati, Ali Abedi, Sara Mostafalou

{"title":"The effect of azelaic acid on AlCl3-induced neurocognitive impairments and molecular changes in the hippocampus of rats.","authors":"Saba Vasegh, Hakimeh Saadati, Ali Abedi, Sara Mostafalou","doi":"10.1017/neu.2024.55","DOIUrl":"10.1017/neu.2024.55","url":null,"abstract":"Objectives: Cognitive function plays a pivotal role in assessing an individual's quality of life. This research aimed to investigate how azelaic acid (AzA), a natural dicarboxylic acid with antioxidant and anti-inflammatory properties, affects aluminium chloride (AlCl3)-induced behavioural changes and biochemical alterations in the hippocampus of rats.Methods: Thirty-two male Wistar rats divided into four groups received distilled water, AzA 50 mg/kg, AlCl3 100 mg/kg and AzA plus AlCl3, respectively, by oral gavage for 6 weeks. Behavioural changes were evaluated using open-field maze, elevated plus maze, novel object recognition (NOR), passive avoidance task, and Morris water maze (MWM) tests. Also, malondialdehyde (MDA), carbonyl protein, tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), nuclear factor-kappa B (NF-κB), C/EBP homologous protein (CHOP), glycogen synthase kinase-3 beta (GSK-3β), brain-derived neurotrophic factor (BDNF) and acetylcholinesterase (AChE) activity were examined.Results: AzA significantly affected AlCl3-provoked anxiety-like behaviours and learning and memory impairments. It also reduced the toxic effect of AlCl3 on MDA, carbonyl protein, TNF-α, IL-1β, NF-κB and GSK-3β status; however, its beneficial effects on AlCl3-induced changes of CHOP, BDNF and AChE activity were not significant.Conclusion: These findings disclosed that AzA could improve behavioural and cognitive function and almost limit the oxidative stress and neuroinflammation caused by AlCl3.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"e43"},"PeriodicalIF":2.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncovering key predictive channels and clinical variables in the gamma band auditory steady-state response in early-stage psychosis: a longitudinal study. 揭示早期精神病患者伽马带听觉稳态反应的关键预测通道和临床变量--一项纵向研究。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-09 DOI: 10.1017/neu.2024.60

Kristina M Holton, Amy Higgins, Austin J Brockmeier, Mei-Hua Hall

{"title":"Uncovering key predictive channels and clinical variables in the gamma band auditory steady-state response in early-stage psychosis: a longitudinal study.","authors":"Kristina M Holton, Amy Higgins, Austin J Brockmeier, Mei-Hua Hall","doi":"10.1017/neu.2024.60","DOIUrl":"10.1017/neu.2024.60","url":null,"abstract":"Objective: Psychotic disorders are characterised by abnormalities in the synchronisation of neuronal responses. A 40 Hz gamma band deficit during auditory steady-state response (ASSR) measured by electroencephalogram (EEG) is a robust observation in psychosis and is associated with symptoms and functional deficits. However, the majority of ASSR studies focus on specific electrode sites, while whole scalp analysis using all channels, and the association with clinical symptoms, are rare.Methods: In this study, we use whole-scalp 40 Hz ASSR EEG measurements – power and phase-locking factor – to establish deficits in early-stage psychosis (ESP) subjects, classify ESP status using an ensemble of machine learning techniques, identify correlates with principal components obtained from clinical/demographic/functioning variables, and correlate functional outcome after a short-term follow-up.Results: We identified significant spatially-distributed group level differences for power and phase locking. The performance of different machine learning techniques and interpretation of the extracted feature importance indicate that phase locking has a more predictive and parsimonious pattern than power. Phase locking is also associated with principal components composed of measures of cognitive processes. Short-term functional outcome is associated with baseline 40 Hz ASSR signals from the FCz and other channels in both phase locking and power.Conclusion: This whole-scalp EEG study provides additional evidence to link deficits in 40 Hz ASSRs with cognition and functioning in ESP, and corroborates with prior studies of phase locking from a subset of EEG channels. Confirming 40 Hz ASSR deficits serves as a candidate phenotype to identify circuit dysfunctions and a biomarker for clinical outcomes in psychosis.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"e1"},"PeriodicalIF":2.6,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats. 胰高血糖素样肽-1和胰淀素受体激动剂的结合减少了雄性和雌性大鼠的酒精摄入量。

IF 2.6 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-06 DOI: 10.1017/neu.2024.58

Cajsa Aranäs, Christian E Edvardsson, Lindsay Zentveld, Daniel Vallöf, Sarah Witley, Maximilian Tufvesson-Alm, Olesya T Shevchouk, Jesper Vestlund, Elisabet Jerlhag

{"title":"The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats.","authors":"Cajsa Aranäs, Christian E Edvardsson, Lindsay Zentveld, Daniel Vallöf, Sarah Witley, Maximilian Tufvesson-Alm, Olesya T Shevchouk, Jesper Vestlund, Elisabet Jerlhag","doi":"10.1017/neu.2024.58","DOIUrl":"10.1017/neu.2024.58","url":null,"abstract":"Objective: Combining different pharmaceuticals may be beneficial when treating disorders with complex neurobiology, including alcohol use disorder (AUD). The gut-brain peptides amylin and GLP-1 may be of potential interest as they individually reduce alcohol intake in rodents. While the combination of amylin receptor (AMYR) and glucagon-like peptide-1 receptor (GLP-1R) agonists have been found to decrease feeding and body weight in obese male rats synergistically, their combined impact on alcohol intake is unknown.Methods: Therefore, the effect of the combination of an AMYR (salmon calcitonin (sCT)) and a GLP-1R (dulaglutide) agonist on alcohol intake in rats of both sexes was explored in two separate alcohol-drinking experiments. The first alcohol-drinking experiment evaluated the potential of adding sCT to an ongoing dulaglutide treatment, whereas the second alcohol-drinking experiment examined the effect when adding sCT and dulaglutide simultaneously.Results: When adding sCT to an ongoing dulaglutide treatment, a reduction in alcohol intake was observed in both male and female rats. However, when combining sCT and dulaglutide simultaneously, an initial reduction in alcohol intake was observed in rats of both sexes, whereas tolerance towards treatment was observed. In both alcohol-drinking experiments, this treatment combination consistently decreased food consumption and body weight in males and females. While the treatment combination did not affect inflammatory mediators, the gene expression of AMYR or GLP-1R, it changed fat tissue morphology.Conclusions: Further investigation needs to be done on the combination of AMYR and GLP-1R agonists to assess their combined effects on alcohol intake.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"e42"},"PeriodicalIF":2.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kappa-opioid receptor blockade in the inferior colliculus of prey threatened by pit vipers decreases anxiety and panic-like behaviour. 阻断受蝮蛇威胁的猎物下丘的卡帕-阿片受体可减少焦虑和恐慌行为。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1017/neu.2024.30

Fabrício Calvo, Tayllon Dos Anjos-Garcia, Tatiana Paschoalin-Maurin, Guilherme Bazaglia-de-Sousa, Bruno Mangili de Paula Rodrigues, Bruno Lobão-Soares, Rafael Carvalho Almada, Carsten T Wotjak, Norberto Cysne Coimbra

{"title":"Kappa-opioid receptor blockade in the inferior colliculus of prey threatened by pit vipers decreases anxiety and panic-like behaviour.","authors":"Fabrício Calvo, Tayllon Dos Anjos-Garcia, Tatiana Paschoalin-Maurin, Guilherme Bazaglia-de-Sousa, Bruno Mangili de Paula Rodrigues, Bruno Lobão-Soares, Rafael Carvalho Almada, Carsten T Wotjak, Norberto Cysne Coimbra","doi":"10.1017/neu.2024.30","DOIUrl":"10.1017/neu.2024.30","url":null,"abstract":"The dorsal midbrain comprises dorsal columns of the periaqueductal grey matter and corpora quadrigemina. These structures are rich in beta-endorphinergic and leu-enkephalinergic neurons and receive GABAergic inputs from substantia nigra pars reticulata. Although the inferior colliculus (IC) is mainly involved in the acoustic pathways, the electrical and chemical stimulation of central and pericentral nuclei of the IC elicits a vigorous defensive behaviour. The defensive immobility and escape elicited by IC activation is commonly related to panic-like emotional states. To investigate the role of κ-opioid receptor of the IC in the antiaversive effects of endogenous opioid receptor blockade in a dangerous situation, male Wistar rats were pretreated in the IC with the κ-opioid receptor-selective antagonist nor-binaltorphimine at different concentrations and submitted to the non-enriched polygonal arena for a snake panic test in the presence of a rattlesnake and, after 24 h, prey were resubmitted to the experimental context. The snakes elicited in prey a set of antipredatory behaviours, such as the anxiety-like responses of defensive attention and risk assessment, and the panic-like reactions of defensive immobility and either escape or active avoidance during the elaboration of unconditioned and conditioned fear-related responses. Pretreatment of the IC with microinjections of nor-binaltorphimine at higher concentrations significantly decreased the frequency and duration of both anxiety- and panic-attack-like behaviours. These findings suggest that κ-opioid receptor blockade in the IC causes anxiolytic- and panicolytic-like responses in threatening conditions, and that kappa-opioid receptor-selective antagonists can be a putative coadjutant treatment for panic syndrome treatment.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"457-469"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between defense styles and neurochemical variables of the hippocampus in patients with obsessive-compulsive disorder. 强迫症患者的防御方式与海马体神经化学变量之间的关系。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1017/neu.2024.33

Murad Atmaca, Mehmet Gurkan Gurok, Muhammed Fatih Tabara, Hanefi Yildirim

{"title":"Relationship between defense styles and neurochemical variables of the hippocampus in patients with obsessive-compulsive disorder.","authors":"Murad Atmaca, Mehmet Gurkan Gurok, Muhammed Fatih Tabara, Hanefi Yildirim","doi":"10.1017/neu.2024.33","DOIUrl":"10.1017/neu.2024.33","url":null,"abstract":"This study aims to assess the correlation between NAA (N-acetyl-l-aspartate), CHO (choline), and CRE (creatine) levels in the hippocampus regions of individuals suffering from obsessive-compulsive disorder (OCD) and defensive styles of the ego.The study group was composed of twenty patients with OCD and twenty healthy controls. NAA, CHO, and CRE values in the hippocampal region using proton magnetic resonance spectroscopy (1H-MRS) were measured. Participants' defense styles were ascertained by administering the Defense Style Questionnaire-40.The patient group's NAA levels were considerably lower than the control group's on both sides of the hippocampus. The levels of CHO and CRE did not significantly differ between the two groups. The following statistically significant correlations were discovered: in the comparison group, there were negative correlations between the scores of mature defense styles and the right and left CHO levels, as well as between the immature defense mechanism scores and the right NAA levels in both the patient and control groups. In the patient group, there were also negative correlations between the left NAA values and the scores of mature defense styles.OCD patients have lower levels of NAA in the hippocampus. To validate and extend the current findings, more research involving a greater sample size is required.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"470-475"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of serum galanin, alarin, meteorin-like protein, and ischemia modified albumin levels in patients with schizophrenia. 精神分裂症患者血清丙氨酸、丙氨酸、流星蛋白样蛋白和缺血修饰白蛋白水平的研究。

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-12-27 DOI: 10.1017/neu.2024.20

Ozlem Gul, Huseyin Fatih Gul, Zozan Parsanoglu, Ozlem Devrim Balaban

{"title":"Investigation of serum galanin, alarin, meteorin-like protein, and ischemia modified albumin levels in patients with schizophrenia.","authors":"Ozlem Gul, Huseyin Fatih Gul, Zozan Parsanoglu, Ozlem Devrim Balaban","doi":"10.1017/neu.2024.20","DOIUrl":"https://doi.org/10.1017/neu.2024.20","url":null,"abstract":"Objective: The objective of the current research is to study the serum levels of ischemia modified albumin (IMA), a new oxidative stress indicator, and various peptides (galanin, alarin, and meteorin-like protein) that may affect the pathophysiology of schizophrenia, determine their relationship with clinical features and each other, and compare them to those in healthy controls.Materials and methods: This is a cross-sectional study consisting of 45 individuals with schizophrenia who are in remission and 45 healthy individuals. The differences and relationships between categorical variables and serum protein levels of the patient and control groups were statistically analysed. Receiver operating characteristics analysis was used for the diagnostic decision-making properties of serum protein levels to predict the presence of the disease.Results: In comparison with the control group, the median levels of serum proteins galanin and alarin were statistically lower in the patient group, whereas METRNL and IMA levels were higher. Considering the predictive values of serum proteins in the diagnosis of the disease, it was observed that serum galanin, alarin, and IMA levels had a sensitivity and specificity higher than 80%, followed by METRNL with 73.3% sensitivity and 66.7% specificity.Conclusion: Our findings reveal galanin, alarin, meteorin-like protein, and IMA are important molecules with high sensitivity and specificity in diagnosing schizophrenia. Furthermore, we think that further studies are needed to use them as reliable parameters in terms of clinical course, classification, and prognosis in explaining the etiopathogenesis of the disease.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"36 6","pages":"485-494"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of morningness-eveningness on depression through a serial mediation model of resilience and anxiety. 通过复原力和焦虑的串联调解模型研究 "早睡早起 "对抑郁症的影响

IF 2.5 4区医学

Acta Neuropsychiatrica Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1017/neu.2024.23

Suhyeon Kang, Huiyeong Kim, Hyeona Yu, Daseul Lee, Hyuk Joon Lee, Tae Hyon Ha, Jungkyu Park, Woojae Myung, Hyo Shin Kang

{"title":"The impact of morningness-eveningness on depression through a serial mediation model of resilience and anxiety.","authors":"Suhyeon Kang, Huiyeong Kim, Hyeona Yu, Daseul Lee, Hyuk Joon Lee, Tae Hyon Ha, Jungkyu Park, Woojae Myung, Hyo Shin Kang","doi":"10.1017/neu.2024.23","DOIUrl":"10.1017/neu.2024.23","url":null,"abstract":"Objective: Resilience has been recently considered one of the possible mechanisms for the association between morningness-eveningness and depression. Meanwhile, anxiety is closely associated with mood disorder, but its association with morningness-eveningness is unclear. Therefore, this study aimed to explore the mediating effects of resilience and anxiety on morningness-eveningness and depression as the possible mechanisms.Methods: This study included patient group and nonpatient group. Patient group consists of 743 patients with mood disorders [Major Depressive Disorder (MDD), 233; Bipolar Disorder I (BDI), 113; Bipolar Disorder II (BDII), 397] whereas nonpatient group consists of 818 individuals without mood disorder. The Composite Scale of Morningness, Connor-Davidson Resilience Scale, Self-Rating Depression Scale, and Beck Anxiety Inventory were used to evaluate morningness-eveningness, resilience, anxiety, and depression, respectively.Results: Our model provided a good fit for the data. The association between morningness-eveningness and depression symptoms was partially serially mediated by resilience and anxiety in both the patient and nonpatient groups. The patient group exhibited significantly stronger morningness-eveningness toward resilience and anxiety than the nonpatient group. In the indirect effect of morningness-eveningness on depression, group differences exist only through each mediation of resilience and anxiety, not through serial mediation.Conclusion: Our results expand on the mechanism underlying the association between morningness-eveningness and depression. They highlight the importance of morningness-eveningness modification to increase resilience and the need to consider anxiety jointly in this process.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"438-445"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0