Acta Neuropsychiatrica最新文献_第9页

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis. GLP-1受体基因多态性与奖励学习、快感缺乏和抑郁症诊断的关系

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-03-26 DOI: 10.1017/neu.2020.14

Hale Yapici-Eser, Vivek Appadurai, Candan Yasemin Eren, Dilek Yazici, Chia-Yen Chen, Dost Öngür, Diego A Pizzagalli, Thomas Werge, Mei-Hua Hall

{"title":"Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.","authors":"Hale Yapici-Eser, Vivek Appadurai, Candan Yasemin Eren, Dilek Yazici, Chia-Yen Chen, Dost Öngür, Diego A Pizzagalli, Thomas Werge, Mei-Hua Hall","doi":"10.1017/neu.2020.14","DOIUrl":"https://doi.org/10.1017/neu.2020.14","url":null,"abstract":"Background: Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.Methods: Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.Results: The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.Conclusion: Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 4","pages":"218-225"},"PeriodicalIF":3.8,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37771908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pharmacological treatments for social anxiety disorder in adults: a systematic review and network meta-analysis. 成人社交焦虑障碍的药物治疗:系统综述和网络荟萃分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-02-10 DOI: 10.1017/neu.2020.6

Taryn Williams, Michael McCaul, Guido Schwarzer, Andrea Cipriani, Dan J Stein, Jonathan Ipser

{"title":"Pharmacological treatments for social anxiety disorder in adults: a systematic review and network meta-analysis.","authors":"Taryn Williams, Michael McCaul, Guido Schwarzer, Andrea Cipriani, Dan J Stein, Jonathan Ipser","doi":"10.1017/neu.2020.6","DOIUrl":"https://doi.org/10.1017/neu.2020.6","url":null,"abstract":"Objective: The aim of this paper was to provide a systematic review and update on the pharmacotherapy of social anxiety disorder (SAD), including the efficacy and tolerability of these agents, the ranking of interventions, and the grading of results by quality of evidence.Methods: The Common Mental Disorder Controlled Trial Register and two trial registries were searched for randomised controlled trials (RCTs) comparing any pharmacological intervention or placebo in the treatment of SAD. We performed a standard pairwise meta-analysis using a random effects model and carried out a network meta-analysis (NMA) using the statistical package, R. Quality of evidence was also assessed.Results: We included 67 RCTs in the review and 21 to 45 interventions in the NMA. Paroxetine was most effective in the reduction of symptom severity as compared to placebo. Superior response to treatment was also observed for paroxetine, brofaromine, bromazepam, clonazepam, escitalopram, fluvoxamine, phenelzine, and sertraline. Higher dropout rates were found for fluvoxamine. Brofaromine, escitalopram, fluvoxamine, paroxetine, pregabalin, sertraline, and venlafaxine performed worse in comparison to placebo for the outcome of dropouts due to adverse events. Olanzapine yielded a relatively high rank for treatment efficacy and buspirone the worse rank for dropouts due to any cause.Conclusion: The differences between drugs and placebo were small, apart from a significant reduction in symptom severity and response for paroxetine. We suggest paroxetine as a first-line treatment of SAD, with the consideration of future research on the drug olanzapine as well as brofaromine, bromazepam, clonazepam, escitalopram, fluvoxamine, phenelzine, and sertraline because we observed a response to treatment.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 4","pages":"169-176"},"PeriodicalIF":3.8,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Auditory brainstem response (ABR) profiling in schizoaffective disorder. 分裂情感性障碍的听觉脑干反应(ABR)分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-08-01 Epub Date: 2020-02-17 DOI: 10.1017/neu.2020.7

Eva Juselius Baghdassarian, Tommy Lewander

{"title":"Auditory brainstem response (ABR) profiling in schizoaffective disorder.","authors":"Eva Juselius Baghdassarian, Tommy Lewander","doi":"10.1017/neu.2020.7","DOIUrl":"https://doi.org/10.1017/neu.2020.7","url":null,"abstract":"Objective: The aim of the study was to assess whether the auditory brainstem response (ABR) profiling test for schizophrenia (SZ) would recognise schizoaffective disorder (SZA) patients as SZ or not.Method: Male and female SZA patients (n = 16) from the psychosis unit at Uppsala University Hospital were investigated. Coded sets of randomised ABR recordings intermingled with patients with SZ, adult attention-deficit hyperactivity disorder (ADHD) and healthy controls were analysed by an independent party blinded to clinical diagnoses.Results: The ABR profiling test for SZ was positive in 5/16 patients (31%) and negative in 11/16 patients (69%) with SZA. A surprising finding was that 4/16 (25%) SZA patients were positive for the ABR profiling test for ADHD.Conclusion: With the ABR profiling test, a minority of patients with SZA tested positive for SZ. In contrast, a majority (85%) of patients with SZ in a previous study tested positive. These preliminary results leave us ignorant whether SZA should be regarded as a SZ-like disorder or a psychotic mood disorder and add to the questions regarding the validity of this diagnostic entity. However, the ABR profiling method is still in its infancy and its exploration in a range of psychiatric disorders is warranted.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":"32 4","pages":"214-217"},"PeriodicalIF":3.8,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2020.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37648522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of 22 serotonin-related genes in rat brain after sub-acute serotonin depletion or reuptake inhibition. 亚急性血清素消耗或再摄取抑制后大鼠大脑中 22 个血清素相关基因的表达。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-02-17 DOI: 10.1017/neu.2020.9

Jakob Näslund, Erik Studer, Staffan Nilsson, Elias Eriksson

{"title":"Expression of 22 serotonin-related genes in rat brain after sub-acute serotonin depletion or reuptake inhibition.","authors":"Jakob Näslund, Erik Studer, Staffan Nilsson, Elias Eriksson","doi":"10.1017/neu.2020.9","DOIUrl":"10.1017/neu.2020.9","url":null,"abstract":"Objective: Although the assessment of expression of serotonin-related genes in experimental animals has become a common strategy to shed light on variations in brain serotonergic function, it remains largely unknown to what extent the manipulation of serotonin levels causes detectable changes in gene expression. We therefore chose to investigate how sub-acute depletion or elevation of brain serotonin influences the expression of a number of serotonin-related genes in six brain areas.Methods: Male Wistar rats were administered a serotonin synthesis inhibitor, para-chlorophenylalanine (p-CPA), or a serotonin reuptake inhibitor, paroxetine, for 3 days and then sacrificed. The expression of a number of serotonin-related genes in the raphe nuclei, hypothalamus, amygdala, striatum, hippocampus and prefrontal cortex was investigated using real-time quantitative PCR (rt-qPCR).Results: While most of the studied genes were uninfluenced by paroxetine treatment, we could observe a robust downregulation of tryptophan hydroxylase-2 in the brain region where the serotonergic cell bodies reside, that is, the raphe nuclei. p-CPA induced a significant increase in the expression of Htr1b and Htr2a in amygdala and of Htr2c in the striatum and a marked reduction in the expression of Htr6 in prefrontal cortex; it also enhanced the expression of the brain-derived neurotrophic factor (Bdnf) in raphe and hippocampus.Conclusion: With some notable exceptions, the expression of most of the studied genes is left unchanged by short-term modulation of extracellular levels of serotonin.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-7"},"PeriodicalIF":3.8,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37648518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disregard the authorship criteria or perish. 无视作者标准，否则就会灭亡。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-02-17 DOI: 10.1017/neu.2020.10

Søren Dinesen Østergaard

引用次数: 0

Post hoc analysis of a randomised, placebo-controlled, active-reference 6-week study of brexpiprazole in acute schizophrenia. 对布来哌唑治疗急性精神分裂症的一项为期 6 周的随机、安慰剂对照、活性参考研究进行事后分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-02-14 DOI: 10.1017/neu.2020.8

Stephen R Marder, Hans Eriksson, Yudong Zhao, Mary Hobart

{"title":"Post hoc analysis of a randomised, placebo-controlled, active-reference 6-week study of brexpiprazole in acute schizophrenia.","authors":"Stephen R Marder, Hans Eriksson, Yudong Zhao, Mary Hobart","doi":"10.1017/neu.2020.8","DOIUrl":"10.1017/neu.2020.8","url":null,"abstract":"Objective: We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint - change from baseline in Positive and Negative Syndrome Scale (PANSS) total score. We also investigate potential expectancy bias from the well-known side-effect profile of the active reference that could have affected the study outcome.Methods: Pre-specified sensitivity analyses of the primary end point were performed using analysis of covariance (ANCOVA) last observation carried forward (LOCF) and observed cases (OC). Post hoc analyses of change from baseline in PANSS total score were performed using the mixed model for repeated measures approach with treatment groups split by having typical adverse events with potential for functional unblinding, for example, somnolence, increase in weight, dizziness, dry mouth and sedation.Results: Pre-specified sensitivity analyses showed separation from placebo for brexpiprazole at week 6: LOCF, ANCOVA: -4.3 [95% CI (-8.0, -0.5), p = 0.0254]. OC, ANCOVA: -3.9 [95% CI (-7.3, -0.5), p = 0.0260]. Patients treated with brexpiprazole experiencing typical adverse events with potential for functional unblinding before or at Week 2 had a least square (LS) mean PANSS change of -29.5 (improvement), with a difference in change from baseline to Week 6 in PANSS total score between brexpiprazole and placebo of -13.5 [95% CI (-23.1, -4.0), p = 0.0057], and those who did not had an LS mean change of -18.9 and a difference between brexpiprazole and placebo of -2.9 [95% CI (-7.2, 1.4), p = 0.1809].Conclusion: Pre-specified sensitivity analyses showed separation from placebo for brexpiprazole at Week 6. A post hoc analysis suggested a potential confounding of efficacy rating towards symptom improvement in patients who experience known side effects of quetiapine XR.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-6"},"PeriodicalIF":3.8,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37640499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene expression in peripheral blood in treatment-free major depression. 未经治疗的重度抑郁症患者外周血中的基因表达。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-02-10 DOI: 10.1017/neu.2020.5

Alfredo B Cuellar-Barboza, Jorge A Sánchez-Ruiz, Iram P Rodriguez-Sanchez, Sarai González, Geovana Calvo, José Lugo, Antonio Costilla-Esquivel, Laura E Martínez, Marisol Ibarra-Ramirez

{"title":"Gene expression in peripheral blood in treatment-free major depression.","authors":"Alfredo B Cuellar-Barboza, Jorge A Sánchez-Ruiz, Iram P Rodriguez-Sanchez, Sarai González, Geovana Calvo, José Lugo, Antonio Costilla-Esquivel, Laura E Martínez, Marisol Ibarra-Ramirez","doi":"10.1017/neu.2020.5","DOIUrl":"10.1017/neu.2020.5","url":null,"abstract":"Background: Peripheral gene expression of several molecular pathways has been studied in major depressive disorder (MDD) with promising results. We sought to investigate some of these genes in a treatment-free Latino sample of Mexican descent.Material and methods: The sample consisted of 50 MDD treatment-free cases and 50 sex and age-matched controls. Gene expression of candidate genes of neuroplasticity (BDNF, p11, and VGF), inflammation (IL1A, IL1B, IL4, IL6, IL7, IL8, IL10, MIF, and TNFA), the canonical Wnt signaling pathway (TCF7L2, APC, and GSK3B), and mTOR, was compared in cases and controls. RNA was obtained from blood samples. We used bivariate analyses to compare subjects versus control mean mRNA quantification of target genes and lineal regression modelling to test for effects of age and body mass index on gene expression.Results: Most subjects were female (66%) with a mean age of 26.7 (SD 7.9) years. Only GSK3B was differentially expressed between cases and controls at a statistically significant level (p = 0.048). TCF7L-2 showed the highest number of correlations with MDD-related traits, yet these were modest in size.Discussion: GSK3B encodes a moderator of the canonical Wnt signaling pathway. It has a role in neuroplasticity, neuroprotection, depression, and other psychiatric phenotypes. We found that adding population diversity has the potential to elicit distinct peripheral gene expression markers in MDD and MDD-related traits. However, our results should only be considered as hypothesis-generating research that merits further replication in larger cohorts of similar ancestry.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-10"},"PeriodicalIF":3.8,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37627537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal restraint stress impairs recognition memory in adult male and female offspring. 产前束缚应激会损害成年雄性和雌性后代的识别记忆。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-01-29 DOI: 10.1017/neu.2020.3

Clarissa A Moura, Matheus C Oliveira, Layse F Costa, Pamella R F Tiago, Victor A D Holanda, Ramon H Lima, Fernanda C Cagni, Bruno Lobão-Soares, Franscico Bolaños-Jiménez, Elaine C Gavioli

{"title":"Prenatal restraint stress impairs recognition memory in adult male and female offspring.","authors":"Clarissa A Moura, Matheus C Oliveira, Layse F Costa, Pamella R F Tiago, Victor A D Holanda, Ramon H Lima, Fernanda C Cagni, Bruno Lobão-Soares, Franscico Bolaños-Jiménez, Elaine C Gavioli","doi":"10.1017/neu.2020.3","DOIUrl":"10.1017/neu.2020.3","url":null,"abstract":"Objective: Accumulating evidence from preclinical and clinical studies indicates that prenatal exposure to stress impairs the development of the offspring brain and facilitates the emergence of mental illness. This study aims to describe the impact of prenatal restraint stress on cognition and exploration to an unfamiliar environment at adulthood in an outbred strain of mice.Methods: Late pregnant mice were exposed to restraint stress and adult offspring (60 days of age) behaviours were assessed in the object recognition task and open field test.Findings: Prenatal stress (PNS) impaired new object recognition in male and female mice. Importantly, the learning deficits in female PNS mice were linked to their estrous cycle. Actually, PNS females in metestrus/diestrus but not in proestrus/estrus phases displayed recognition deficits compared to controls. Concerning locomotion in an unfamiliar environment, male but not female PNS mice displayed significant increase, but showed no differences in the distance travelled within the centre zone of the arena.Conclusion: Present findings support the view that maternal restraint-stress during late pregnancy impairs recognition memory in both male and female offspring, and in females, this cognitive deficit is dependent on the estrous cycle phase. Ultimately, these data reinforce that PNS is an aetiological component of psychiatric disorders associated with memory deficits.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-6"},"PeriodicalIF":3.8,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of D-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients. D-丝氨酸在重复经颅磁刺激对中风后患者的益处中的作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-01-29 DOI: 10.1017/neu.2020.4

Masachika Niimi, Yuko Fujita, Tamaki Ishima, Kenji Hashimoto, Nobuyuki Sasaki, Takatoshi Hara, Naoki Yamada, Masahiro Abo

{"title":"Role of D-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients.","authors":"Masachika Niimi, Yuko Fujita, Tamaki Ishima, Kenji Hashimoto, Nobuyuki Sasaki, Takatoshi Hara, Naoki Yamada, Masahiro Abo","doi":"10.1017/neu.2020.4","DOIUrl":"10.1017/neu.2020.4","url":null,"abstract":"Objective: Abnormalities in neurotransmission via N-methyl-D-aspartic acid receptor (NMDAR) play a role in the pathophysiology of neuropsychiatric disorders. The impact of repetitive transcranial magnetic stimulation (rTMS) on NMDAR-related amino acids remains unknown. We aim to investigate the effects of rTMS on NMDAR-related amino acids in serum of post-stroke patients.Methods: Ninety-five consecutive post-stroke patients with upper limb hemiparesis were recruited. In 27 patients, the Beck Depression Inventory (BDI) score was 10 or higher. Twelve depressed patients underwent rehabilitation in combination with rTMS and 15 non-depressed patients underwent rehabilitation only without rTMS for 14 days. 1 Hz rTMS was applied to the primary motor area in the non-lesional hemisphere. BDI was conducted before and after treatment. Serum glutamine, glutamate, glycine, L-serine, and D-serine levels were measured before and after treatment.Results: There were no differences between depressed patients and non-depressed patients in clinical characteristics, levels of the five amino acids in serum, and the ratio of amino acids. However, in 27 depressed patients there was a significant correlation between levels of glutamate in serum and BDI (ρ=0.428、p=0.026). BDI decreased significantly in depressed patients after treatment with or without rTMS. D-serine decreased in the rehabilitation with rTMS group, but increased in the rehabilitation without rTMS group. L-serine increased in the rehabilitation with rTMS group, but decreased in the rehabilitation without rTMS group.Conclusions: The results suggest that rTMS can modulate NMDAR-related amino acids in blood, producing beneficial effects.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-22"},"PeriodicalIF":3.8,"publicationDate":"2020-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review. 抑郁症中 HPA 轴基因与童年虐待之间的基因环境相互作用：系统综述。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2020-01-06 DOI: 10.1017/neu.2020.1

Caroline Normann, Henriette N Buttenschøn

{"title":"Gene-environment interactions between HPA-axis genes and childhood maltreatment in depression: a systematic review.","authors":"Caroline Normann, Henriette N Buttenschøn","doi":"10.1017/neu.2020.1","DOIUrl":"10.1017/neu.2020.1","url":null,"abstract":"Objective: Gene-environment (GxE) interactions may comprise an important part of the aetiology of depression, and childhood maltreatment (CM), a significant stressor, has consistently been linked to depression. Hence, in this systematic review, we aimed to investigate the interaction between hypothalamus-pituitary-adrenal axis (HPA-axis) genes and CM in depression.Methods: We conducted a literature search using the Pubmed, Embase, and PsychINFO databases in adherence with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. We included studies investigating GxE interactions between HPA-axis genes [Angiotensin Converting Enzyme (ACE), Arginine Vasopressin (AVP), Corticotrophin Releasing Hormone (CRH), Corticotrophin Releasing Hormone Receptor 1 (CRHR1), Corticotrophin Releasing Hormone Receptor 2 (CRHR2), FK506 binding protein (FKBP5), Nuclear Receptor subfamily 3 group C member 1 (NR3C1), Nuclear Receptor subfamily 3 group C member 2 (NR3C2)] and CM in depression.Results: The literature search identified 159 potentially relevant studies. Following screening, 138 of these were excluded. Thus, 21 studies, investigating a total of 51 single nucleotide polymorphisms, were included in the final study. The most prevalent genes in the current study were CRHR1 and FKBP5. Significant GxE interactions were reported in seven of eight studies for CRHR1:rs110402 and CM, and in five of eight studies for FKBP5:rs1360780 and CM. In summary, our results suggest possible GxE interactions between CRHR1, FKBP5, NR3C1, and NR3C2 and CM, respectively. For the remaining genes, no relevant literature emerged.Conclusions: We find that genetic variation in four HPA-axis genes may influence the effects of CM in depression.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":" ","pages":"1-11"},"PeriodicalIF":3.8,"publicationDate":"2020-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37512428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0