Acta Neuropsychiatrica最新文献_第9页

A 2-year follow-up study of patients participating in our transcranial pulsating electromagnetic fields augmentation in treatment-resistant depression. 参与我们的经颅脉冲电磁场增强治疗难治性抑郁症患者的2年随访研究。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-04-01 Epub Date: 2015-01-13 DOI: 10.1017/neu.2014.44

Per Bech, Lone Lindberg, Birgit Straasø, Erik Roj Larsen

{"title":"A 2-year follow-up study of patients participating in our transcranial pulsating electromagnetic fields augmentation in treatment-resistant depression.","authors":"Per Bech, Lone Lindberg, Birgit Straasø, Erik Roj Larsen","doi":"10.1017/neu.2014.44","DOIUrl":"https://doi.org/10.1017/neu.2014.44","url":null,"abstract":"Objective: We have made a 2-year follow-up study to evaluate the effect of repeated transcranial pulsating electromagnetic fields (T-PEMF) augmentation in patients who had achieved remission but later on relapsed, as well as to identify factors contributing to treatment-resistant depression in patients who did not respond to T-PEMF.Methods: Using the Longitudinal Expert Assessment of All Data approach the patients were classified in four groups: A: patients who achieved remission; B: patients with doubtful effect; C: patients with no effect; and D: patients who were hard-to-assess.Results: In group A, comprising 27 patients, 13 had relapsed; they obtained a clear remission after a repeated course of T-PEMF augmentation. In group D, comprising 16 patients, we identified misdiagnostic factors both concerning the event of remission after the previous T-PEMF augmentation and concerning the aetiology (psychosocial stressors and co-morbid conditions). Compared with the other groups, the group D patients had a smaller number of previous episodes (p=0.09) and a longer duration of the current episode (p=0.01).Conclusion: T-PEMF has an effect among patients who relapsed after remission with the first series of T-PEMF. Treatment-resistant depression is a condition that has a high degree of multivariate problems. Misuse of alcohol or drugs, severe somatic disorders and other psychosocial problems may need other kinds of treatment before T-PEMF augmentation.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.44","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32969789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Risk of bipolar disorder and psychotic features in patients initially hospitalised with severe depression. 最初因严重抑郁症住院的患者双相情感障碍的风险和精神病特征

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-04-01 Epub Date: 2014-12-22 DOI: 10.1017/neu.2014.42

Kimiya Nakamura, Junichi Iga, Naoki Matsumoto, Tetsuro Ohmori

{"title":"Risk of bipolar disorder and psychotic features in patients initially hospitalised with severe depression.","authors":"Kimiya Nakamura, Junichi Iga, Naoki Matsumoto, Tetsuro Ohmori","doi":"10.1017/neu.2014.42","DOIUrl":"https://doi.org/10.1017/neu.2014.42","url":null,"abstract":"Objective: Severe depression may be a risk factor for diagnostic conversion into bipolar disorder (BD), and psychotic depression (PD) has been consistently associated with BD. The aims of the present study were to investigate the stability of the diagnosis of severe depression and the differences between PD and non-psychotic severe depression (non-PD), as well as to assess the effectiveness of electroconvulsive therapy (ECT).Methods: Patients who were hospitalised for severe depression (diagnosed according to ICD-10) both with and without psychotic symptoms (n=89; mean age=55.6 years, SD=13.9) from 2001 to 2010 were retrospectively assessed.Results: By the 75th month of follow-up assessments, 11(12.4%) patients had developed BD. Among these 11 converters, nine had developed BD within 1 year after admission. Only sub-threshold hypomanic symptoms were significantly related to developing BD. The number of depressive episodes and history of physical diseases were significantly increased in non-PD compared with PD patients, whereas ECT was significantly increased in PD compared with non-PD patients. There was a significant association between length of stay at the hospital and the number of days between admission and ECT.Conclusion: Sub-threshold hypomanic symptoms may represent a prodrome of BD or an indicator of an already manifest phenotype, especially in older patients, which suggests cautious use of antidepressants. In severe depression, non-PD may often occur secondary to physical diseases and patients may experience increased recurrences compared with PD patients, which may be a more 'primary' disorder and often requires ECT treatments. ECT is effective for severe depression regardless of the presence of any psychotic feature; the earlier ECT is introduced, the better the expected treatment outcome.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.42","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32924711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Unrecognised myocardial infarction in patients with schizophrenia. 精神分裂症患者未被识别的心肌梗死。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-04-01 Epub Date: 2015-01-13 DOI: 10.1017/neu.2014.41

Jimmi Nielsen, Jacob Juel, Karam Sadoon Alzuhairi, Karam Sadoon Majeed Al Zuhairi, Rasmus Friis, Claus Graff, Jørgen Kim Kanters, Svend Eggert Jensen

{"title":"Unrecognised myocardial infarction in patients with schizophrenia.","authors":"Jimmi Nielsen, Jacob Juel, Karam Sadoon Alzuhairi, Karam Sadoon Majeed Al Zuhairi, Rasmus Friis, Claus Graff, Jørgen Kim Kanters, Svend Eggert Jensen","doi":"10.1017/neu.2014.41","DOIUrl":"https://doi.org/10.1017/neu.2014.41","url":null,"abstract":"Objective: Schizophrenia is associated with a reduction of the lifespan by 20 years, with type II diabetes and cardiovascular disease contributing the most to the increased mortality. Unrecognised or silent myocardial infarction (MI) occurs in ~30% of the population, but the rates of unrecognised MI in patients with schizophrenia have only been sparsely investigated.Method: Electrocardiograms (ECG) from three psychiatric hospitals in Denmark were manually interpreted for signs of previous MI. Subsequently, ECGs were linked to the National Patient Registry in order to determine whether patients had a diagnosis consistent with previous MI.Results: A total of 937 ECGs were interpreted, 538 men (57.4%) and 399 women (42.6%). Mean age at the time of ECG acquisition was 40.6 years (95% CI: 39.7-41.5, range: 15.9-94.6). We identified 32 patients with positive ECG signs of MIs. Only two of these patients had a diagnosis of MI in the National Patient Registry. An additional number of eight patients had a diagnosis of MI in the Danish National Patient Registry, but with no ECG signs of previous MI. This means that 30 out of 40 (75%) MIs were unrecognised. Only increasing age was associated with unrecognised MI in a stepwise multiple logistic regression model compared with patients with no history of MI, OR: 1.03 per year of age, 95% CI: 1.00-1.06, p=0.021.Conclusion: Unrecognised MI is common among patients with schizophrenia and may contribute to the increased mortality found in this patient group.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.41","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32970157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression. 在弗林德斯敏感系大鼠抑郁症模型中，一氧化氮参与氯胺酮的抗抑郁样作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-04-01 Epub Date: 2014-12-10 DOI: 10.1017/neu.2014.39

Nico Liebenberg, Sâmia Joca, Gregers Wegener

{"title":"Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression.","authors":"Nico Liebenberg, Sâmia Joca, Gregers Wegener","doi":"10.1017/neu.2014.39","DOIUrl":"https://doi.org/10.1017/neu.2014.39","url":null,"abstract":"Objective: We investigated whether the nitric oxide (NO) precursor, L-arginine, can prevent the antidepressant-like action of the fast-acting antidepressant, ketamine, in a genetic rat model of depression, and/or induce changes in the glutamate (Glu)/N-methyl-D-aspartate receptor (NMDAR)/NO/cyclic guanosine monophosphate (cGMP) signalling pathway. Hereby it was evaluated whether the NO signalling system is involved in the antidepressant mechanism of ketamine.Methods: Flinders sensitive line (FSL) rats received single i.p. injections of ketamine (15 mg/kg) with/without pre-treatment (30 min prior) with L-arginine (500 mg/kg). Depression-like behaviour was assessed in the forced swim test (FST) in terms of immobility, and the activation state of the Glu/NMDAR/NO/cGMP pathway was evaluated ex vivo in the frontal cortex and hippocampus regions in terms of total constitutive NOS (cNOS) activity and cGMP concentration.Results: L-Arginine pre-treatment prevented the antidepressant-like effect of ketamine in the FST, as well as a ketamine-induced increase in cGMP levels in the frontal cortex and hippocampus of FSL rats. Ketamine reduced cNOS activity only in the hippocampus, and this effect was not reversed by L-arginine.Conclusion: Both the behavioural and molecular results from this study indicate an involvement for the NO signalling pathway in the antidepressant action of ketamine. Although not easily interpretable, these findings broaden our knowledge of effects of ketamine on the NO system.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32895089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Contribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyrone. 痛觉肽/孤啡肽FQ受体在双吡酮抗痛觉和降体温作用中的作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-12-03 DOI: 10.1017/neu.2014.38

Ismet Hande Ertin, Ozgur Gunduz, Ahmet Ulugol

{"title":"Contribution of nociceptin/orphanin FQ receptors to the anti-nociceptive and hypothermic effects of dipyrone.","authors":"Ismet Hande Ertin, Ozgur Gunduz, Ahmet Ulugol","doi":"10.1017/neu.2014.38","DOIUrl":"https://doi.org/10.1017/neu.2014.38","url":null,"abstract":"Background: Dipyrone is one of the most commonly used non-opioid analgesic and antipyretic drug. Its anti-nociceptive and hypothermic effects have long been suspected to be centrally mediated. The involvement of the most recently discovered opioid peptide, nociceptin/orphanin FQ (N/OFQ), and its receptor (NOP) in pain transmission is controversial. It appears to be pro-nociceptive when administered supra-spinally, but exerts anti-nociceptive effects when injected spinally or systemically.Objective: Investigation of the role of the N/OFQ system in paracetamol-induced anti-nociception and hypothermia led us to determine its role in the anti-nociceptive and hypothermic effects of dipyrone. Material and Methods Hot-plate and tail-flick tests were used to assess nociception, and a rectal thermometer was used to measure rectal temperature in mice.Results: Mice injected with dipyrone (150, 300, 600 mg/kg, i.p.) displayed dose-related anti-nociception and hypothermia. The NOP receptor antagonist JTC-801 (3 mg/kg, i.p.), at a dose that exerted no effect when used alone, alleviated dipyrone-induced anti-nociception but did not reverse dipyrone-induced hypothermia.Conclusion: We conclude that NOP receptors participate in the anti-nociceptive, but not in the hypothermic, effects of dipyrone.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32874062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Hoarding pet animals in obsessive-compulsive disorder. 囤积宠物强迫症患者。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-10-31 DOI: 10.1017/neu.2014.29

André L Campos-Lima, Albina R Torres, Murat Yücel, Ben J Harrison, Jorge Moll, Gabriela M Ferreira, Leonardo F Fontenelle

引用次数: 11

Neuropsychological profile of a male psychiatric patient with a Morgagni-Stewart-Morel syndrome. 一位患有Morgagni-Stewart-Morel综合征的男性精神病患者的神经心理学分析。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-11-10 DOI: 10.1017/neu.2014.32

Aksel Hansen, Liliana Engelhardt, Wolfgang Pleschutznig, Gerhard Dammann, Stephanie Vietze

{"title":"Neuropsychological profile of a male psychiatric patient with a Morgagni-Stewart-Morel syndrome.","authors":"Aksel Hansen, Liliana Engelhardt, Wolfgang Pleschutznig, Gerhard Dammann, Stephanie Vietze","doi":"10.1017/neu.2014.32","DOIUrl":"https://doi.org/10.1017/neu.2014.32","url":null,"abstract":"In 1765 Giovanni Morgagni described a syndrome consisting of hyperostosis frontalis interna (HFI), obesity and hirsutism. In 1928 Stewart and in 1930 Morel added neuropsychiatric symptoms, e.g. depression and dementia, which led to the definition of the Morgagni-Stewart-Morel Syndrome (MSM). Although mostly women were characterized in literature no gender specifity is demanded. This case report presents the rare case of a 66 year old male psychiatric patient with Morgagni-Stewart-Morel Syndrome. The patient complained of loss of concentration and difficulties with activities of daily living. Admission diagnosis was an opioid misuse on the basis of a chronic pain syndrome. In this case report we are describing clinical features, the patient history and technical (MRI) and neuropsychological tests. Although severe psychiatric symptoms and neuropsychological deficits are commonly seen in these patients, our patient showed only mild symptoms. This case reports shows the possibility of a male patient with MSM. If MSM is a separate entity or just an epiphenomena of hormone dysregulation should be investigated in further studies. ","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32803009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment. 慢性治疗后GLP-1受体激动剂对皮质酮释放有持续的刺激作用。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-12-03 DOI: 10.1017/neu.2014.36

Maarja Krass, Annika Volke, Kertu Rünkorg, Gregers Wegener, Sten Lund, Anders Abildgaard, Eero Vasar, Vallo Volke

{"title":"GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment.","authors":"Maarja Krass, Annika Volke, Kertu Rünkorg, Gregers Wegener, Sten Lund, Anders Abildgaard, Eero Vasar, Vallo Volke","doi":"10.1017/neu.2014.36","DOIUrl":"https://doi.org/10.1017/neu.2014.36","url":null,"abstract":"Objective: Glucagon-like peptide 1 (GLP-1) receptor agonists are a new group of antidiabetic medications quickly gaining popularity. We aimed to examine behavioural and neuroendocrine changes following chronic treatment with GLP-1 receptor agonists in animal models.Methods: The effects of chronic treatment with GLP-1 receptor agonists were determined on behavioural parameters [anxiety level in the light-dark compartment test, the motor activity in automated activity cages, immobility in the forced swimming test (FST)] and on corticosterone release in mice. The possible antidepressant effect of chronic liraglutide treatment was also studied in Flinders Sensitive Line (FSL) rats, a genetic model of depression.Results: Two weeks of treatment with exenatide (10 µg/kg twice daily) or liraglutide (1200 µg/kg once daily) did not affect the anxiety level in a light-dark compartment test nor induce an antidepressant-like effect in the FST in mice. Moreover, chronic treatment with liraglutide had no effect on depression-related behaviour in FSL rats. Interestingly, hypolocomotion induced by the drugs in mice disappeared after chronic dosing. Both of the GLP-1 receptor agonists induced robust increases in corticosterone levels in mice under basal conditions as well as in the case of combination with swimming stress. Remarkably, exenatide was as potent a stimulator of corticosterone release after 2 weeks as after acute administration.Conclusions: The increases in corticosterone release seen after acute exenatide or liraglutide treatment do not abate after 2 weeks of treatment demonstrating that tolerance does not develop towards this particular effect of GLP-1 agonists.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32878010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

The Diagnostic Apathia Scale predicts a dose-remission relationship of T-PEMF in treatment-resistant depression. 诊断性冷漠量表预测治疗难治性抑郁症中T-PEMF的剂量-缓解关系。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-10-02 DOI: 10.1017/neu.2014.26

Per Bech, Marianne Lunde, Lise Lauritzen, Birgit Straasø, Lone Lindberg, Maj Vinberg, Mogens Undén, Lone Christina Hellström, Steen Dissing, Erik Roj Larsen

{"title":"The Diagnostic Apathia Scale predicts a dose-remission relationship of T-PEMF in treatment-resistant depression.","authors":"Per Bech, Marianne Lunde, Lise Lauritzen, Birgit Straasø, Lone Lindberg, Maj Vinberg, Mogens Undén, Lone Christina Hellström, Steen Dissing, Erik Roj Larsen","doi":"10.1017/neu.2014.26","DOIUrl":"https://doi.org/10.1017/neu.2014.26","url":null,"abstract":"Objective: The aim of this study was to evaluate the predictive validity of the apathy subsyndrome in patients with therapy-resistant depression in the dose-remission study with transcranial pulsating electromagnetic fields (T-PEMF).Methods: The apathy subsyndrome consists of the symptoms of fatigue, concentration and memory problems, lack of interests, difficulties in making decisions, and sleep problems. We evaluated 65 patients with therapy-resistant depression. In total, 34 of these patients received placebo T-PEMF in the afternoon and active T-PEMF in the morning, that is, one daily dose. The remaining 31 patients received active T-PEMF twice daily. Duration of treatment was 8 weeks in both groups. The Hamilton Depression Scale (HAM-D17) and the Bech-Rafaelsen Melancholia Scale (MES) were used to measure remission. We also focused on the Diagnostic Apathia Scale, which is based on a mixture of items from the MINI and the HAM-D17/MES.Results: In patients without apathy, the remission rate after T-PEMF was 83.9% versus 58.8% in patients with apathy (p≤0.05). In patients without apathy receiving one active dose daily 94.4% remitted versus 50% for patients with apathy (p≤0.05). In patients without apathy who received two active doses 69.9% remitted versus 66.7% for patients with apathy (p≤0.05).Conclusion: Taking the baseline diagnosis of the apathy syndrome into consideration, we found that in patients without apathy one daily dose of T-PEMF is sufficient, but in patients with apathy two daily doses are necessary. Including the apathy syndrome as predictor in future studies would seem to be clinically relevant.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32711968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Decreased delta sleep ratio and elevated alpha power predict vulnerability to depression during interferon-alpha treatment. δ睡眠比例降低和α功率升高预示着在α干扰素治疗期间易患抑郁症。

IF 3.8 4区医学

Acta Neuropsychiatrica Pub Date : 2015-02-01 Epub Date: 2014-12-01 DOI: 10.1017/neu.2014.30

Francis E Lotrich, Anne Germain

{"title":"Decreased delta sleep ratio and elevated alpha power predict vulnerability to depression during interferon-alpha treatment.","authors":"Francis E Lotrich, Anne Germain","doi":"10.1017/neu.2014.30","DOIUrl":"https://doi.org/10.1017/neu.2014.30","url":null,"abstract":"Objective: Although poor sleep accompanies depression, it is unknown which specific sleep abnormalities precede depression. This is similarly the case for depression developing during interferon-α (IFN-α) therapy. Because vulnerability becomes evident in those who slept poorly before IFN-α, we prospectively determined which specific aspect of sleep could predict subsequent depression.Methods: Two nights of polysomnography with quantitative electroencephalogram (EEG) were obtained in 24 adult, euthymic subjects--all subsequently treated with IFN-α for hepatitis C. Every 2 weeks, a Beck Depression Inventory-II (BDI-II) score was obtained, and the maximal increase in BDI-II from pre-treatment baseline--excluding the sleep question--was determined.Results: The delta sleep ratio (DSR; an index of early-night restorative delta power) was inversely associated with BDI-II increases (p<0.01), as was elevated alpha power (8-12 Hz; p<0.001). Both delta (0.5-4 Hz) and alpha power exhibited high between-night correlations (r=0.83 and 0.92, respectively). In mixed-effect repeated-measure analyses, there was an interaction between alpha power and DSR (p<0.001)--subjects with low alpha power and elevated DSR were resilient to developing depression. Most other sleep parameters--including total sleep time and percentage of time in slow wave sleep--were not associated with subsequent changes in depression.Conclusions: Both high DSR and low alpha power may be specific indices of resilience. As most other aspects of sleep were not associated with resilience or vulnerability, sleep interventions to prevent depression may need to specifically target these specific sleep parameters.","PeriodicalId":48964,"journal":{"name":"Acta Neuropsychiatrica","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/neu.2014.30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32846730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12