Cannabidiol improves non-motor symptoms, attenuates neuroinflammation, and favours hippocampal newborn neuronal maturation in a rat model of Parkinsonism.

IF 2.6 4区医学 Q3 NEUROSCIENCES

Acta Neuropsychiatrica Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI:10.1017/neu.2024.15

Bianca Andretto de Mattos, Jéssica Mendes Bonato, Maria Clara Splendor, Elaine Del Bel, Humberto Milani, Rúbia Maria Weffort de Oliveira

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引用次数: 0

Abstract

Objective: To investigate the effects of cannabidiol (CBD) on emotional and cognitive symptoms in rats with intra-nigral 6-hydroxydopamine (6-OHDA) lesions.

Methods: Adult male Wistar rats received bilateral intranigral 6-OHDA infusions and were tested in a battery of behavioural paradigms to evaluate non-motor symptoms. The brains were obtained to evaluate the effects of CBD on hippocampal neurogenesis.

Results: 6-OHDA-lesioned rats exhibited memory impairments and despair-like behaviour in the novelty-suppressed feeding test and forced swim test, respectively. The animals also exhibited dopaminergic neuronal loss in the substantia nigra pars compacta (SNpc), striatum, and ventral tegmental area and a reduction of hippocampal neurogenesis. CBD decreased dopaminergic neuronal loss in the SNpc, reduced the mortality rate and decreased neuroinflammation in 6-OHDA-lesioned rats. In parallel, CBD prevented memory impairments and attenuated despair-like behaviour that were induced by bilateral intranigral 6-OHDA lesions. Repeated treatment with CBD favoured the neuronal maturation of newborn neurons in the hippocampus in Parkinsonian rats.

Conclusion: The present findings suggest a potential beneficial effect of CBD on non-motor symptoms induced by intra-nigral 6-OHDA infusion in rats.

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在帕金森病大鼠模型中，大麻二酚可改善非运动症状、减轻神经炎症并促进海马新生神经元成熟。

目的研究大麻二酚（CBD）对鼻内6-羟基多巴胺（6-OHDA）损伤大鼠情绪和认知症状的影响：成年雄性 Wistar 大鼠接受双侧鞘内 6-OHDA 输注，并接受一系列行为范式测试，以评估非运动症状。获取大鼠大脑以评估 CBD 对海马神经发生的影响：结果：6-羟基多巴胺缺失大鼠在新奇感抑制喂食试验和强迫游泳试验中分别表现出记忆障碍和绝望样行为。这些动物还表现出黑质、纹状体和腹侧被盖区多巴胺能神经元的缺失，以及海马神经发生的减少。大麻二酚减少了黑质前部（SNpc）多巴胺能神经元的损失，降低了死亡率，并减少了6-OHDA缺失大鼠的神经炎症。与此同时，大麻二酚还能防止双侧鞘内6-OHDA病变诱发的记忆损伤和绝望样行为。CBD的重复治疗有利于帕金森大鼠海马新生神经元的成熟：本研究结果表明，CBD 对大鼠颅内 6-OHDA 输注诱发的非运动症状具有潜在的有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY

自引率

5.30%

发文量

期刊介绍： Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.