American Journal of Drug and Alcohol Abuse最新文献

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Day-to-day discrimination and substance use treatment motivation among justice-involved adults experiencing homelessness. 无家可归的成年人的日常歧视和药物使用治疗动机。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-03-04 Epub Date: 2025-03-05 DOI: 10.1080/00952990.2025.2466188
Priya B Thomas, Jamie M Gajos, Jennifer M Reingle Gonzalez, Rebecca Molsberry Marcolina, Karen L Cropsey, Sydney Gilmer, Rodolfo A Perez, Michael S Businelle
{"title":"Day-to-day discrimination and substance use treatment motivation among justice-involved adults experiencing homelessness.","authors":"Priya B Thomas, Jamie M Gajos, Jennifer M Reingle Gonzalez, Rebecca Molsberry Marcolina, Karen L Cropsey, Sydney Gilmer, Rodolfo A Perez, Michael S Businelle","doi":"10.1080/00952990.2025.2466188","DOIUrl":"10.1080/00952990.2025.2466188","url":null,"abstract":"<p><p><i>Background:</i> Adults experiencing homelessness (AEH) disproportionately suffer from substance use disorders (SUD) and under-utilize SUD treatments compared with the general population. AEH with a recent history of justice involvement (AEH+J) face additional treatment barriers related to discrimination and criminal history.<i>Objective:</i> To describe types of discrimination that AEH+J experience and assess whether the type of discrimination experienced impacts motivation for SUD treatment by SUD severity.<i>Methods:</i> We analyzed data from 164 AEH+J (85% male, 54% non-Hispanic Black) from the Link2Care cohort. ANOVA and linear regression analyses tested for associations between discrimination type, SUD treatment motivation, and SUD severity. Multivariable linear regression models examined associations between discrimination types and SUD treatment motivation by SUD severity level.<i>Results:</i> The majority of AEH+J experienced discrimination (90%), primarily due to homeless status (27%) and race (27%). AEH+J with severe SUD had a significantly greater motivation for SUD treatment than those with mild/moderate disorders (mean difference: 7.34, <i>p</i> < .0001). Discrimination type was not directly associated with SUD severity or treatment motivation. However, among participants with severe SUD, AEH+J who experienced race-related discrimination had lower treatment motivation than those who did not experience discrimination (β = -6.17, <i>p</i> = .03).<i>Conclusion:</i> Results support allocating scarce publicly available SUD treatment resources to AEH+J with the greatest need and motivation to receive treatment. Results also highlight the importance of screening for discriminatory experiences, especially to those who primarily experience race-related discrimination, to improve motivation for SUD treatment among AEH+J with severe SUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"263-272"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young sexual and gender minority men's perspectives on drug checking services in Metro Vancouver, Canada: a qualitative study. 加拿大大温哥华地区年轻性取向和少数性别男性对毒品检查服务的看法:一项定性研究。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-03-04 Epub Date: 2025-02-10 DOI: 10.1080/00952990.2024.2443940
Koharu Loulou Chayama, Pierre-Julien Coulaud, Cameron Schwartz, Olivier Ferlatte, Lianping Ti, Rod Knight
{"title":"Young sexual and gender minority men's perspectives on drug checking services in Metro Vancouver, Canada: a qualitative study.","authors":"Koharu Loulou Chayama, Pierre-Julien Coulaud, Cameron Schwartz, Olivier Ferlatte, Lianping Ti, Rod Knight","doi":"10.1080/00952990.2024.2443940","DOIUrl":"10.1080/00952990.2024.2443940","url":null,"abstract":"<p><p><i>Background:</i> Young sexual and gender minority (SGM) men experience disproportionate risk of drug-related harms. Improving access to drug checking services (DCS), where people can receive information about the contents of their illicit drugs, is critical to facilitate safer drug use among this population. However, no research to date has explored their perspectives on DCS.<i>Objectives:</i> To explore perspectives on DCS among young SGM men in Metro Vancouver, Canada.<i>Methods:</i> Semi-structured interviews were conducted with 50 young (ages 18-30) SGM men living in Metro Vancouver in 2018. Interviews were audio-recorded, transcribed verbatim, and coded. Themes were identified using inductive-deductive approaches and interpreted by drawing on the Risk Environment Framework.<i>Results:</i> Two key themes emerged. First, participants generally had limited awareness and experience with DCS. Nevertheless, given concerns over the increasingly toxic drug supply, they perceived benefits to getting their drugs tested, including reducing their risk of overdose. Second, participants identified social (e.g. anti-drug stigma), policy/legal (e.g. drug criminalization), and physical (e.g. lack of services outside of downtown Vancouver) barriers in the current context of DCS. To improve access, participants encouraged the expansion of DCS in community settings (e.g. bars) and through community-based approaches (e.g. integration within community sexual health programming) tailored for young SGM men.<i>Conclusion:</i> Despite low levels of awareness and experience with DCS, young SGM men demonstrated a strong interest in accessing these services. Efforts to adapt and scale up DCS need to account for the social, policy/legal, and physical contexts that shape the lives of young SGM men.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"214-224"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levels of support and consumer perceptions of cannabis regulations in Canada. 加拿大大麻法规的支持度和消费者看法。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-03-04 Epub Date: 2025-04-02 DOI: 10.1080/00952990.2025.2479152
Anastasia Marquette, David Hammond
{"title":"Levels of support and consumer perceptions of cannabis regulations in Canada.","authors":"Anastasia Marquette, David Hammond","doi":"10.1080/00952990.2025.2479152","DOIUrl":"10.1080/00952990.2025.2479152","url":null,"abstract":"<p><p><i>Background:</i> Canada legalized cannabis for adult (recreational) use in 2018, alongside regulations on the sale, use, and possession of cannabis. To date, there is little evidence on consumer perceptions and support of cannabis regulations.<i>Objectives:</i> This study examined perceptions of nine cannabis regulatory policies, including differences by cannabis consumption and provincial policy.<i>Methods:</i> National survey data were analyzed from Wave 5 of the International Cannabis Policy Study conducted online in 2022 with 16,812 Canadians aged 16+ years, 62% of which were assigned female-at-birth. Weighted logistic regression models examined support for nine policy variables.<i>Results:</i> Support among Canadians was greatest for health warnings on cannabis products (62.6%), legalization for adult use (58.5%), and retail store window-coverings (49.2%), followed by a vaping/extract THC limit (40.1%), retail store density (35.5%), government-only store models (34.6%), the THC limit on edibles (32.3%), and advertising restrictions (31.8%). The 30 g purchasing limit had the least consumer support (10.1%). As consumption increased, opposition generally increased, although support remained high among consumers. Compared to non-consumers, daily consumers were more likely to oppose window-coverings (OR = 1.43, CI95 = 1.16-1.75, <i>p</i> = .001). Where policies differed provincially, few differences in support were observed. No differences in support for THC limits on vaping/extracts were observed between Newfoundland, Nova Scotia, and Quebec versus the rest of Canada, despite stronger vaping/extract regulations (OR = 1.05, CI95 = 0.87-1.28, <i>p</i> = .597).<i>Conclusion:</i> Canadians generally support existing cannabis regulations that were implemented to support public health. The high level of support among consumers suggests that the comprehensive regulations may not undermine transitions to legal retail sources.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"237-253"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
American Indian women's perceptions of perinatal cannabis use. 美国印第安妇女对围产期大麻使用的看法。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-03-04 Epub Date: 2025-03-14 DOI: 10.1080/00952990.2025.2473399
Celestina Barbosa-Leiker, Olivia Brooks, Crystal Lederhos Smith, Shayla C Reid, Gusti Lulu Fatima, Katherine A Hirchak, Randi Arias-Losado, Margaret Cabell
{"title":"American Indian women's perceptions of perinatal cannabis use.","authors":"Celestina Barbosa-Leiker, Olivia Brooks, Crystal Lederhos Smith, Shayla C Reid, Gusti Lulu Fatima, Katherine A Hirchak, Randi Arias-Losado, Margaret Cabell","doi":"10.1080/00952990.2025.2473399","DOIUrl":"10.1080/00952990.2025.2473399","url":null,"abstract":"<p><p><i>Background:</i> Cannabis use during pregnancy continues to rise, yet research examining cannabis use in perinatal American Indian women is lacking. Structural injustices have led to health inequities for American Indian people, including higher prevalence of past-month cannabis use and lower prevalence of receiving mental health treatment, compared to other racial and ethnic groups.<i>Objective:</i> To describe perceptions of risks and benefits of perinatal cannabis use in a sample of American Indian perinatal women who report regularly using cannabis while pregnant.<i>Method:</i> A qualitative descriptive study was conducted with 10 American Indian perinatal women who reported using cannabis at least weekly while pregnant or postpartum. Participants were from three states where cannabis use is legal for adults (Washington, Oregon, and California). Themes were generated from implicit and explicit participant responses and principles of Indigenous research frameworks were utilized.<i>Results:</i> Four themes were derived from the data: 1) Perinatal cannabis use as better than other substances, 2) Medicinal use and perceived therapeutic effects of prenatal cannabis, 3) Unsure if cannabis use while breastfeeding impacts the baby, and 4) Minimal responses from healthcare providers perceived as approval.<i>Conclusions:</i> Cannabis was used for health-related issues and was perceived to be a safer option for than use of methamphetamine, heroin, alcohol, and prescription pharmaceuticals. With a focus on other substance use issues within participants' communities, minimal discussion about cannabis use by healthcare providers was perceived as endorsement of use, highlighting the need for additional training for healthcare providers.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"254-262"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Speed and accuracy of online searches by legislators and medical students using RefBin's opioid use disorder database. 立法者和医科学生使用 RefBin 的阿片类药物使用障碍数据库进行在线搜索的速度和准确性。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-03-04 Epub Date: 2025-02-24 DOI: 10.1080/00952990.2025.2450431
Katelynn Giroux, David Krag, Richard Single, Shania Prytherch, Sydney White, Sarah Niknaum
{"title":"Speed and accuracy of online searches by legislators and medical students using RefBin's opioid use disorder database.","authors":"Katelynn Giroux, David Krag, Richard Single, Shania Prytherch, Sydney White, Sarah Niknaum","doi":"10.1080/00952990.2025.2450431","DOIUrl":"10.1080/00952990.2025.2450431","url":null,"abstract":"<p><p><i>Background:</i> Literature regarding opioid use disorder (OUD) is often difficult for nonscientific communities to access. The OUD database on RefBin categorizes scientific findings and may facilitate access to information regarding OUD.<i>Objectives:</i> To evaluate if the RefBin OUD database improves access to information about OUD for policymakers and medical students.<i>Methods:</i> 31 medical students and 13 individual policymakers completed this study. Using a cross-over method, participants answered questions about OUD. Speed, accuracy, confidence, and satisfaction metrics were collected and compared between searches that used RefBin vs other resources chosen by participants.<i>Results:</i> At baseline, medical students reported being comfortable with scientific literature and familiar with OUD. Policymakers reported low comfort levels with scientific literature and variable familiarity with OUD. Within the medical student sample, the odds of answering correctly were 2.43 times higher for RefBin searches than for searches using resources other than RefBin (non-RefBin searches) (<i>p</i> = .005; 95% CI: (1.31, 4.51)). For policymakers, the odds of answering correctly were 3.65 times higher for RefBin vs non-RefBin searches (<i>p</i> = .0496; 95% CI: [1.002, 13.279]). Medical students reported feeling confident in their results 50.7% of the time when using RefBin, compared to 28.3% with non-RefBin searches (<i>p</i> = .006).<i>Conclusion:</i> When compared with searching using non-RefBin sources, searches performed using RefBin resulted in improved accuracy and efficiency for both medical students and policymakers. This demonstrates the potential utility of the RefBin OUD database in improving access to reliable information about OUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"173-179"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using digitally delivered measurement-based care in substance use disorder treatment: qualitative analysis of patients' perspectives. 在物质使用障碍治疗中使用数字化交付的基于测量的护理:对患者观点的定性分析。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-02-24 DOI: 10.1080/00952990.2025.2458626
Tessa Frohe, Eliza B Cohn, Madeline C Frost, Tascha R Johnson, Kevin A Hallgren
{"title":"Using digitally delivered measurement-based care in substance use disorder treatment: qualitative analysis of patients' perspectives.","authors":"Tessa Frohe, Eliza B Cohn, Madeline C Frost, Tascha R Johnson, Kevin A Hallgren","doi":"10.1080/00952990.2025.2458626","DOIUrl":"https://doi.org/10.1080/00952990.2025.2458626","url":null,"abstract":"<p><p><i>Background:</i> Measurement-based care (MBC) is a clinical practice where patients complete standardized outcome measures throughout treatment to monitor clinical progress and inform clinical decision-making. However, MBC is rarely adopted in routine substance use disorder (SUD) treatment. We developed a digital MBC system and pilot tested it in an outpatient adult community SUD treatment setting.<i>Objectives:</i> The current study aims to characterize qualitative feedback from the pilot participants about their experiences using the MBC system in SUD treatment, focusing on perceived benefits, drawbacks, and suggestions for improvement.<i>Methods:</i> Participants (<i>N</i> = 30; <i>n</i> = 11 female 37%) completed weekly MBC questionnaires via smartphone for 6 months and completed structured interviews at 6-, 12-, and 24-weeks. Themes were identified using a combination of inductive/deductive thematic analysis.<i>Results:</i> Participants highlighted several benefits of using the digital MBC system, including improved self-reflection (e.g. goal clarification, noticing changes over time), treatment enhancement (e.g. improving patient-clinician communication, extending the reach of treatment beyond scheduled sessions), and ease-of-use (e.g. brief, understandable questions). Drawbacks were less frequently expressed and included limited integration with clinical care, repetitiveness of questionnaires, and some questions being difficult to answer. Suggestions included making elements more personalized and improving interactivity with the digital interface.<i>Conclusion:</i> Patients report several benefits of integrating digitally delivered MBC into SUD treatment, along with recommendations that may improve its usability and usefulness. Integrating MBC technology into SUD treatment may potentially aid patients by enhancing self-reflection, facilitating more efficient communication with clinicians, and extending the reach of treatment beyond scheduled treatment sessions.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Readiness to stop smoking and subsequent switching away to electronic nicotine delivery systems among adults who smoke cigarettes. 在吸烟的成年人中戒烟的意愿和随后转向电子尼古丁输送系统。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-02-20 DOI: 10.1080/00952990.2024.2439363
Saul Shiffman, Sooyong Kim, Nicholas I Goldenson, Mark A Sembower
{"title":"Readiness to stop smoking and subsequent switching away to electronic nicotine delivery systems among adults who smoke cigarettes.","authors":"Saul Shiffman, Sooyong Kim, Nicholas I Goldenson, Mark A Sembower","doi":"10.1080/00952990.2024.2439363","DOIUrl":"https://doi.org/10.1080/00952990.2024.2439363","url":null,"abstract":"<p><p><i>Background:</i> Adults who smoke cigarettes (AWS) who switch to electronic nicotine delivery systems (ENDS) are likely to reduce their health risks.<i>Objectives:</i> To explore ENDS-users' readiness to stop smoking (RTSS) when adopting ENDS, the prospective association of RTSS and switching away from smoking (past-30-day abstinence), and the role of frequency of JUUL use in switching.<i>Methods:</i> Analyses used data from a naturalistic 2-year longitudinal study of 17,393 AWS (55.4% male) who had purchased a JUUL Starter Kit.<i>Results:</i> Only 20% were planning to stop smoking within 7 days at baseline but had the highest likelihood of switching, 70% at Month-24 (vs. in a year or more: OR = 2.33; 95%CI = 2.13-2.55). Those planning to stop smoking within 30 days (24%), 6 months (24%) or a year or more (27%) had switch rates of 53 ~ 59% at Month-24; those who planned never to quit (6%) had 51% switch rates. Daily ENDS use was prospectively associated with the highest likelihood of subsequent switching (vs. infrequent: OR = 1.68; 95%CI = 1.60-1.77); frequent users (≥20 days/month) also had higher switch rates (OR = 1.22; 95%CI = 1.15-1.28). Descriptively, participants higher on RTSS were more likely to be daily or frequent users, but frequency of use neither interacted with RTSS, nor mediated its association with switching.<i>Conclusions:</i> Most ENDS adopters were not ready to stop smoking, and would not be candidates for cessation treatment. However, a majority - even of those never planning to quit - were abstinent from cigarettes two years later. ENDS may facilitate smoking abstinence in populations not reached by traditional cessation interventions.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adolescent binge drinking in male Wistar rats increases ethanol consumption and reduces intoxication sensitivity in early adulthood without affecting withdrawal. 雄性Wistar大鼠青少年酗酒增加乙醇消耗量,降低成年早期的中毒敏感性,但不影响戒断。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-02-19 DOI: 10.1080/00952990.2025.2464644
Camila Ravasi, Agustín Salguero, Leonardo Marengo, Pedro Peñalver, Ricardo Marcos Pautassi
{"title":"Adolescent binge drinking in male Wistar rats increases ethanol consumption and reduces intoxication sensitivity in early adulthood without affecting withdrawal.","authors":"Camila Ravasi, Agustín Salguero, Leonardo Marengo, Pedro Peñalver, Ricardo Marcos Pautassi","doi":"10.1080/00952990.2025.2464644","DOIUrl":"https://doi.org/10.1080/00952990.2025.2464644","url":null,"abstract":"<p><p><i>Background:</i> Early adolescent ethanol exposure increases the risk of developing an alcohol use disorder. The mechanisms underlying this relationship may involve early ethanol exposure influencing anxiety or altering ethanol sensitivity.<i>Objectives:</i> To examine how adolescent binge drinking impacts sensitivity to ethanol intoxication, withdrawal symptoms, anxiety, compulsive behaviors, and ethanol intake in adulthood.<i>Methods:</i> Thirty-seven male Wistar rats self-administered ethanol during adolescence [postnatal days (PD) 27-45] or were housed under control conditions. In adulthood, the rats received intragastric intubations to simulate heavy alcohol (PDs 61-65, 3 daily doses of 0.0 or 1.5 g/kg) exposure. Intoxication and withdrawal symptoms were assessed (PDs 61-70), along with compulsive behaviors (marble burying test, PD68) and anxiety-related behaviors (light-dark box and elevated plus maze tests, PDs 69-70). Two-bottle choice tests provided measures of ethanol intake (PDs 75-87).<i>Results:</i> Adolescent binge exposure increased ethanol consumption in adulthood (<i>p</i> < .001; η2 = 0.51), with binge-exposed rats drinking 4.5-6.5 g/kg/day vs. 2 g/kg/day in controls. Binge-exposed rats exhibited reduced sensitivity to ethanol intoxication (<i>p</i> < .05; η2 = 0.17). Withdrawal symptoms were significantly greater (<i>p</i> < .005; η2 = 0.36) in rats exposed to alcohol during adulthood compared to controls, regardless of binge ethanol exposure. Anxiety or compulsive behaviors were unaffected by binge ethanol.<i>Conclusions:</i> Adolescent binge drinking led, in male rats, to significant increases in ethanol intake and reduced sensitivity to intoxication in adulthood. These findings suggest that early ethanol exposure results in decreased ethanol sensitivity, potentially increasing the likelihood of ethanol use. Adolescent binge drinking is a key vulnerability factor, and interventions should target this behavior.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing substance-involved suicide and unintentional deaths from 2011 to 2021 in Missouri, United States. 比较2011年至2021年美国密苏里州涉及药物的自杀和非故意死亡。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-02-19 DOI: 10.1080/00952990.2024.2435275
Khrystyna Stetsiv, Melissa Nance, Maria Paschke, Rachel Winograd, Ryan W Carpenter
{"title":"Comparing substance-involved suicide and unintentional deaths from 2011 to 2021 in Missouri, United States.","authors":"Khrystyna Stetsiv, Melissa Nance, Maria Paschke, Rachel Winograd, Ryan W Carpenter","doi":"10.1080/00952990.2024.2435275","DOIUrl":"https://doi.org/10.1080/00952990.2024.2435275","url":null,"abstract":"<p><p><i>Background:</i> Substance-involved suicide and unintentional overdose deaths share risk factors, yet our understanding of how these deaths overlap and differ remains limited. Direct comparisons of substance-involved suicide and unintentional deaths are lacking.<i>Objective:</i> To guide effective prevention and intervention efforts regarding substance-involved suicide, we examined risk factors, demographic and substance-related, of substance-involved suicide and unintentional deaths.<i>Methods:</i> Using logistic and multinomial regression, we used medical examiner records obtained annually (<i>N</i> = 6,467, 72% male) to examine characteristics associated with suicide and unintentional substance-involved deaths in St. Louis, Missouri between 2011 and 2021.<i>Results:</i> Between 2011 and 2021, age-standardized suicide rates slightly decreased (3.55 to 3.33), while unintentional deaths nearly tripled (23.2 to 68.2). Many deaths involved both alcohol and traumatic injury, and almost a fifth of suicides involved prescription opioids. In the logistic model (combining data across 11 years), the following factors were associated with increased odds of suicide, relative to unintentional deaths: White race (OR = 5.42, 95%CI[3.95,7.56]), greater age (OR = 1.01, 95%CI[1.00,1.02]), traumatic injury (OR = 4.40, 95%CI[3.17,6.13]), and presence of not otherwise classified substances (including prescription medications; OR = 4.36, 95%CI[3.11,6.10]). The following were associated with decreased odds of suicide: presence of medical condition (OR = 0.32, 95%CI[0.23,0.45]), fentanyl (OR = 0.04, 95%CI[0.02,0.06]), ethanol (OR = 0.64, 95%CI[0.46,0.88]), cocaine (OR = 0.40, 95%CI[0.24,0.63]), heroin (OR = 0.05, 95%CI[0.03,0.09]), and other stimulants (OR = 0.32, 95%CI[0.20,0.50]).<i>Conclusions:</i> Results suggest a divergence over time in the rates of classified substance-involved suicide and unintentional deaths. A distinctive set of demographic and substance use characteristics differentiated the two manners of death, highlighting potential risk factors to inform further research and targeted interventions.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Daily drinking intention-behavior discrepancies are associated with drinking-related consequences. 日常饮酒的意图-行为差异与饮酒相关的后果有关。
IF 2.7 3区 医学
American Journal of Drug and Alcohol Abuse Pub Date : 2025-02-13 DOI: 10.1080/00952990.2025.2454405
Emily Junkin, Karolina Kazlauskaite, Cathy Lau-Barraco
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