American Journal of Drug and Alcohol Abuse最新文献

{"title":"Applied statistical methods for identifying features of heart rate that are associated with nicotine vaping.","authors":"Puyang Zhao, James J Yang, Anne Buu","doi":"10.1080/00952990.2024.2441868","DOIUrl":"10.1080/00952990.2024.2441868","url":null,"abstract":"<p><p><i>Background:</i> Wearable devices have been increasingly adopted to collect physiological data such as heart rate that may infer momentary risk of substance use. Yet, innovative methods capable for handling these complex time series data as presented in the statistics or data science literature may not be accessible to substance use researchers.<i>Objectives:</i> This study introduces a series of statistical methods to analyze heart rate data and identify features that are associated with nicotine vaping.<i>Methods:</i> Nontechnical description of the methods coupled with the information about open-source software packages that implemented these methods was provided. The analytical procedure included 5 steps: (1) de-noising by the singular spectrum analysis (SSA); (2) sleep region identification by the Sum of Single Effects (SuSiE) model; (3) repeated heart rate pattern identification by the matrix profile; (4) dimension reduction by the linear regression; and (5) comparing repeated heart rate patterns across non-vaping and vaping regions by the linear mixed model. Secondary analysis was conducted on heart rate and ecological momentary assessment (EMA) data collected from 35 young adult e-cigarette users (66% female) for 7 days.<i>Results:</i> Effectiveness of the methods was demonstrated by graphical presentations showing that the extracted features characterize sleep patterns and heart rate changes before and after vaping events quite well. Secondary analysis found that heart rate was higher and changed faster before vaping.<i>Conclusion:</i> Statistical methods can effectively extract useful features from heart rate data that may inform momentary vaping risk and optimal timings for delivering messages in mobile-phone based interventions.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"165-172"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the perspectives of police officers regarding men who use drugs and drug rehabilitation in China: a qualitative study.","authors":"Yajing Ma, Bronya Hi Kwan Luk, Wen Zhang, Cody Yu Cheung Cham, Haixia Ma","doi":"10.1080/00952990.2024.2447294","DOIUrl":"10.1080/00952990.2024.2447294","url":null,"abstract":"<p><p><i>Background:</i> Drug use among men is a significant public health concern in China, with compulsory drug treatment centers being the primary approach. Police officers in these centers play a crucial role in shaping the interactions and experiences of men who use drugs (MWUD). However, little research exists on the attitudes of police officers toward MWUD in China.<i>Objectives:</i> This qualitative study aimed to explore the attitudes of police officers toward MWUD and drug rehabilitation approaches in China.<i>Methods:</i> Semi-structured individual interviews were conducted among 23 police officers recruited from two compulsory drug treatment centers in Jiangsu Province, China. Of the participants, two were females and 21 were males. Thematic analysis was employed to analyze the data.<i>Results:</i> Three key themes emerged: 1) Multifaceted perspectives on MWUD. Participants viewed MWUD as offenders, victims, and patients. 2) Dynamic interactions with MWUD. Relationships were characterized as either adversarial or supportive, influenced by participants' personalities, experiences, beliefs, workload, and psychological training. 3) Advocating for punitive measures in drug rehabilitation. While the participants generally favored strict penalties for MWUD, they acknowledged the value of community-based rehabilitation. Concerns about social stigma, privacy, motivation, and the costs of voluntary rehabilitation tempered their support.<i>Conclusions:</i> The study highlights the importance of raising awareness and challenging bias among police officers. It emphasizes the need for psychological training to enhance their capacity to provide humane care and foster positive interactions with MWUD. Additionally, ensuring access to affordable, accessible, and stigma-free voluntary rehabilitation is crucial for effective drug rehabilitation efforts.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"204-213"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young sexual and gender minority men's perspectives on drug checking services in Metro Vancouver, Canada: a qualitative study.","authors":"Koharu Loulou Chayama, Pierre-Julien Coulaud, Cameron Schwartz, Olivier Ferlatte, Lianping Ti, Rod Knight","doi":"10.1080/00952990.2024.2443940","DOIUrl":"10.1080/00952990.2024.2443940","url":null,"abstract":"<p><p><i>Background:</i> Young sexual and gender minority (SGM) men experience disproportionate risk of drug-related harms. Improving access to drug checking services (DCS), where people can receive information about the contents of their illicit drugs, is critical to facilitate safer drug use among this population. However, no research to date has explored their perspectives on DCS.<i>Objectives:</i> To explore perspectives on DCS among young SGM men in Metro Vancouver, Canada.<i>Methods:</i> Semi-structured interviews were conducted with 50 young (ages 18-30) SGM men living in Metro Vancouver in 2018. Interviews were audio-recorded, transcribed verbatim, and coded. Themes were identified using inductive-deductive approaches and interpreted by drawing on the Risk Environment Framework.<i>Results:</i> Two key themes emerged. First, participants generally had limited awareness and experience with DCS. Nevertheless, given concerns over the increasingly toxic drug supply, they perceived benefits to getting their drugs tested, including reducing their risk of overdose. Second, participants identified social (e.g. anti-drug stigma), policy/legal (e.g. drug criminalization), and physical (e.g. lack of services outside of downtown Vancouver) barriers in the current context of DCS. To improve access, participants encouraged the expansion of DCS in community settings (e.g. bars) and through community-based approaches (e.g. integration within community sexual health programming) tailored for young SGM men.<i>Conclusion:</i> Despite low levels of awareness and experience with DCS, young SGM men demonstrated a strong interest in accessing these services. Efforts to adapt and scale up DCS need to account for the social, policy/legal, and physical contexts that shape the lives of young SGM men.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"214-224"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Day-to-day discrimination and substance use treatment motivation among justice-involved adults experiencing homelessness.","authors":"Priya B Thomas, Jamie M Gajos, Jennifer M Reingle Gonzalez, Rebecca Molsberry Marcolina, Karen L Cropsey, Sydney Gilmer, Rodolfo A Perez, Michael S Businelle","doi":"10.1080/00952990.2025.2466188","DOIUrl":"10.1080/00952990.2025.2466188","url":null,"abstract":"<p><p><i>Background:</i> Adults experiencing homelessness (AEH) disproportionately suffer from substance use disorders (SUD) and under-utilize SUD treatments compared with the general population. AEH with a recent history of justice involvement (AEH+J) face additional treatment barriers related to discrimination and criminal history.<i>Objective:</i> To describe types of discrimination that AEH+J experience and assess whether the type of discrimination experienced impacts motivation for SUD treatment by SUD severity.<i>Methods:</i> We analyzed data from 164 AEH+J (85% male, 54% non-Hispanic Black) from the Link2Care cohort. ANOVA and linear regression analyses tested for associations between discrimination type, SUD treatment motivation, and SUD severity. Multivariable linear regression models examined associations between discrimination types and SUD treatment motivation by SUD severity level.<i>Results:</i> The majority of AEH+J experienced discrimination (90%), primarily due to homeless status (27%) and race (27%). AEH+J with severe SUD had a significantly greater motivation for SUD treatment than those with mild/moderate disorders (mean difference: 7.34, <i>p</i> < .0001). Discrimination type was not directly associated with SUD severity or treatment motivation. However, among participants with severe SUD, AEH+J who experienced race-related discrimination had lower treatment motivation than those who did not experience discrimination (β = -6.17, <i>p</i> = .03).<i>Conclusion:</i> Results support allocating scarce publicly available SUD treatment resources to AEH+J with the greatest need and motivation to receive treatment. Results also highlight the importance of screening for discriminatory experiences, especially to those who primarily experience race-related discrimination, to improve motivation for SUD treatment among AEH+J with severe SUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"263-272"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of support and consumer perceptions of cannabis regulations in Canada.","authors":"Anastasia Marquette, David Hammond","doi":"10.1080/00952990.2025.2479152","DOIUrl":"10.1080/00952990.2025.2479152","url":null,"abstract":"<p><p><i>Background:</i> Canada legalized cannabis for adult (recreational) use in 2018, alongside regulations on the sale, use, and possession of cannabis. To date, there is little evidence on consumer perceptions and support of cannabis regulations.<i>Objectives:</i> This study examined perceptions of nine cannabis regulatory policies, including differences by cannabis consumption and provincial policy.<i>Methods:</i> National survey data were analyzed from Wave 5 of the International Cannabis Policy Study conducted online in 2022 with 16,812 Canadians aged 16+ years, 62% of which were assigned female-at-birth. Weighted logistic regression models examined support for nine policy variables.<i>Results:</i> Support among Canadians was greatest for health warnings on cannabis products (62.6%), legalization for adult use (58.5%), and retail store window-coverings (49.2%), followed by a vaping/extract THC limit (40.1%), retail store density (35.5%), government-only store models (34.6%), the THC limit on edibles (32.3%), and advertising restrictions (31.8%). The 30 g purchasing limit had the least consumer support (10.1%). As consumption increased, opposition generally increased, although support remained high among consumers. Compared to non-consumers, daily consumers were more likely to oppose window-coverings (OR = 1.43, CI95 = 1.16-1.75, <i>p</i> = .001). Where policies differed provincially, few differences in support were observed. No differences in support for THC limits on vaping/extracts were observed between Newfoundland, Nova Scotia, and Quebec versus the rest of Canada, despite stronger vaping/extract regulations (OR = 1.05, CI95 = 0.87-1.28, <i>p</i> = .597).<i>Conclusion:</i> Canadians generally support existing cannabis regulations that were implemented to support public health. The high level of support among consumers suggests that the comprehensive regulations may not undermine transitions to legal retail sources.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"237-253"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speed and accuracy of online searches by legislators and medical students using RefBin's opioid use disorder database.","authors":"Katelynn Giroux, David Krag, Richard Single, Shania Prytherch, Sydney White, Sarah Niknaum","doi":"10.1080/00952990.2025.2450431","DOIUrl":"10.1080/00952990.2025.2450431","url":null,"abstract":"<p><p><i>Background:</i> Literature regarding opioid use disorder (OUD) is often difficult for nonscientific communities to access. The OUD database on RefBin categorizes scientific findings and may facilitate access to information regarding OUD.<i>Objectives:</i> To evaluate if the RefBin OUD database improves access to information about OUD for policymakers and medical students.<i>Methods:</i> 31 medical students and 13 individual policymakers completed this study. Using a cross-over method, participants answered questions about OUD. Speed, accuracy, confidence, and satisfaction metrics were collected and compared between searches that used RefBin vs other resources chosen by participants.<i>Results:</i> At baseline, medical students reported being comfortable with scientific literature and familiar with OUD. Policymakers reported low comfort levels with scientific literature and variable familiarity with OUD. Within the medical student sample, the odds of answering correctly were 2.43 times higher for RefBin searches than for searches using resources other than RefBin (non-RefBin searches) (<i>p</i> = .005; 95% CI: (1.31, 4.51)). For policymakers, the odds of answering correctly were 3.65 times higher for RefBin vs non-RefBin searches (<i>p</i> = .0496; 95% CI: [1.002, 13.279]). Medical students reported feeling confident in their results 50.7% of the time when using RefBin, compared to 28.3% with non-RefBin searches (<i>p</i> = .006).<i>Conclusion:</i> When compared with searching using non-RefBin sources, searches performed using RefBin resulted in improved accuracy and efficiency for both medical students and policymakers. This demonstrates the potential utility of the RefBin OUD database in improving access to reliable information about OUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"173-179"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American Indian women's perceptions of perinatal cannabis use.","authors":"Celestina Barbosa-Leiker, Olivia Brooks, Crystal Lederhos Smith, Shayla C Reid, Gusti Lulu Fatima, Katherine A Hirchak, Randi Arias-Losado, Margaret Cabell","doi":"10.1080/00952990.2025.2473399","DOIUrl":"10.1080/00952990.2025.2473399","url":null,"abstract":"<p><p><i>Background:</i> Cannabis use during pregnancy continues to rise, yet research examining cannabis use in perinatal American Indian women is lacking. Structural injustices have led to health inequities for American Indian people, including higher prevalence of past-month cannabis use and lower prevalence of receiving mental health treatment, compared to other racial and ethnic groups.<i>Objective:</i> To describe perceptions of risks and benefits of perinatal cannabis use in a sample of American Indian perinatal women who report regularly using cannabis while pregnant.<i>Method:</i> A qualitative descriptive study was conducted with 10 American Indian perinatal women who reported using cannabis at least weekly while pregnant or postpartum. Participants were from three states where cannabis use is legal for adults (Washington, Oregon, and California). Themes were generated from implicit and explicit participant responses and principles of Indigenous research frameworks were utilized.<i>Results:</i> Four themes were derived from the data: 1) Perinatal cannabis use as better than other substances, 2) Medicinal use and perceived therapeutic effects of prenatal cannabis, 3) Unsure if cannabis use while breastfeeding impacts the baby, and 4) Minimal responses from healthcare providers perceived as approval.<i>Conclusions:</i> Cannabis was used for health-related issues and was perceived to be a safer option for than use of methamphetamine, heroin, alcohol, and prescription pharmaceuticals. With a focus on other substance use issues within participants' communities, minimal discussion about cannabis use by healthcare providers was perceived as endorsement of use, highlighting the need for additional training for healthcare providers.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"254-262"},"PeriodicalIF":2.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent binge drinking in male Wistar rats increases ethanol consumption and reduces intoxication sensitivity in early adulthood without affecting withdrawal.","authors":"Camila Ravasi, Agustín Salguero, Leonardo Marengo, Pedro Peñalver, Ricardo Marcos Pautassi","doi":"10.1080/00952990.2025.2464644","DOIUrl":"https://doi.org/10.1080/00952990.2025.2464644","url":null,"abstract":"<p><p><i>Background:</i> Early adolescent ethanol exposure increases the risk of developing an alcohol use disorder. The mechanisms underlying this relationship may involve early ethanol exposure influencing anxiety or altering ethanol sensitivity.<i>Objectives:</i> To examine how adolescent binge drinking impacts sensitivity to ethanol intoxication, withdrawal symptoms, anxiety, compulsive behaviors, and ethanol intake in adulthood.<i>Methods:</i> Thirty-seven male Wistar rats self-administered ethanol during adolescence [postnatal days (PD) 27-45] or were housed under control conditions. In adulthood, the rats received intragastric intubations to simulate heavy alcohol (PDs 61-65, 3 daily doses of 0.0 or 1.5 g/kg) exposure. Intoxication and withdrawal symptoms were assessed (PDs 61-70), along with compulsive behaviors (marble burying test, PD68) and anxiety-related behaviors (light-dark box and elevated plus maze tests, PDs 69-70). Two-bottle choice tests provided measures of ethanol intake (PDs 75-87).<i>Results:</i> Adolescent binge exposure increased ethanol consumption in adulthood (<i>p</i> < .001; η2 = 0.51), with binge-exposed rats drinking 4.5-6.5 g/kg/day vs. 2 g/kg/day in controls. Binge-exposed rats exhibited reduced sensitivity to ethanol intoxication (<i>p</i> < .05; η2 = 0.17). Withdrawal symptoms were significantly greater (<i>p</i> < .005; η2 = 0.36) in rats exposed to alcohol during adulthood compared to controls, regardless of binge ethanol exposure. Anxiety or compulsive behaviors were unaffected by binge ethanol.<i>Conclusions:</i> Adolescent binge drinking led, in male rats, to significant increases in ethanol intake and reduced sensitivity to intoxication in adulthood. These findings suggest that early ethanol exposure results in decreased ethanol sensitivity, potentially increasing the likelihood of ethanol use. Adolescent binge drinking is a key vulnerability factor, and interventions should target this behavior.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between college enrollment and trends in substance use among young adults in the US from 2015 to 2019.","authors":"James Aluri, Himani Byregowda, Amelia Arria","doi":"10.1080/00952990.2024.2400923","DOIUrl":"10.1080/00952990.2024.2400923","url":null,"abstract":"<p><p><i>Background:</i> Substance use among college students has negative academic and health outcomes. Identifying substances that are more commonly used by students than non-students can reveal specific risks in the college environment.<i>Objectives:</i> To examine associations between college enrollment and prevalence and trends of use of a comprehensive list of substances.<i>Methods:</i> The sample included 2015-2019 participants in the National Survey on Drug Use and Health who were aged 18 to 22 and who were full-time enrolled or not enrolled in college. Prevalence of substance use was calculated for four subgroups: college males (<i>n</i> = 6,707), college females (<i>n</i> = 8,284), non-college males (<i>n</i> = 10,019), and non-college females (<i>n</i> = 9,266). Multivariate logistic regression was used to model the relationships between enrollment and substance use. Temporal trends in substance use prevalence were calculated for each subgroup.<i>Results:</i> College enrollment was associated with prescription stimulant misuse (aOR 1.50, 95% CI: 1.35-1.67), alcohol use (aOR 1.36, 95% CI: 1.27-1.47), and binge drinking (aOR 1.22, 95% CI: 1.15-1.30). From 2015 to 2019, the only substance whose use significantly increased among any subgroup was cannabis. The increase occurred among females only (+4.7% in college females and +5.6% in non-college females; both <i>p</i> < .01).<i>Conclusions:</i> College enrollment is most strongly associated with prescription stimulant misuse, suggesting that colleges should consider explicitly including stimulant misuse prevention in their health promotion strategies. The increasing use of cannabis among females warrants clinicians' attention to routine screening for use and provision of information about the mental health impacts of cannabis.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"96-106"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Withdrawal interference scale: a novel measure of withdrawal-related life disruption in opioid use disorder and alcohol use disorder.","authors":"Orman Trent Hall, Tommy Gunawan, Julie Teater, Craig Bryan, Stephanie Gorka, Vijay A Ramchandani","doi":"10.1080/00952990.2024.2350057","DOIUrl":"10.1080/00952990.2024.2350057","url":null,"abstract":"<p><p><i>Background:</i> <i>Hyperkatifeia</i> describes amplified emotional and motivational withdrawal due to addiction-related sensitization of brain-stress-systems. Hyperkatifeia has been proposed as a target for addiction treatment development. However, translation of basic research in this area will require new tools designed to measure <i>hyperkatifeia</i> and related phenomena outside of laboratory settings.<i>Objectives:</i> We define a novel concept, <i>withdrawal interference</i>, and introduce a new tool - the <i>Withdrawal Interference Scale</i> (WIS) - which measures the impact of withdrawal on daily life among individuals with OUD or AUD.<i>Methods:</i> Described are the combined results of three separate cross-sectional studies. The structural validity, convergent validity, construct validity, trans-diagnostic (AUD/OUD) configural, metric, and scalar invariance, internal consistency, and composite reliability of WIS was tested among three independent samples of 1) treatment-seeking adults with OUD (<i>n</i> = 132), 2) treatment-seeking adults with AUD (<i>n</i> = 123), and 3) non-treatment-seeking adults with OUD (<i>n</i> = 140). Males numbered 218 and females were 163.<i>Results:</i> WIS exhibited structural validity (1 factor), convergent validity (average variance extracted .670-.676), construct validity, trans-diagnostic configural (χ2/df = 2.10), metric (Δχ2 = 5.70, <i>p</i> = .681), and scalar invariance (Δχ2 = 12.34, <i>p</i> = .338), internal consistency (α .882-928), and composite reliability (.924-.925).<i>Conclusion:</i> These results suggest WIS is a valid and reliable instrument for measuring withdrawal-related life disruption in AUD and OUD. Further, given our findings of transdiagnostic measurement invariance, WIS scores of individuals with AUD and OUD can be meaningfully compared in future statistical analyses.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"44-56"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}