Kelly A Campbell, Anna L Wilson, Marilyn Torres, Neha Dantuluri, Kimberly Fryer
{"title":"Risk factors of overdose in maternal patients with opioid use disorder: a scoping review.","authors":"Kelly A Campbell, Anna L Wilson, Marilyn Torres, Neha Dantuluri, Kimberly Fryer","doi":"10.1080/00952990.2024.2407006","DOIUrl":"10.1080/00952990.2024.2407006","url":null,"abstract":"<p><p><i>Background:</i> Opioid-related overdoses significantly contribute to mortality in pregnancy and the postpartum period. Few studies report risk factors predisposing pregnant and postpartum patients with opioid use disorder (OUD) to overdose.<i>Objective:</i> This scoping review aims to describe the risk factors predisposing pregnant and postpartum patients with OUD to overdose.<i>Method:</i> Included studies identified pregnant and/or postpartum patients with OUD and differentiated between those who experienced overdose and those who did not. Of the 1060 articles, 8 met the criteria, examining 90,860 pregnant and postpartum patients with OUD.<i>Results:</i> Consistent use of medications for OUD (MOUD) during pregnancy and the postpartum period was the most frequently identified factor reducing overdose risk. Critical times of heightened overdose risk include the first trimester and the 7-12-month postpartum period. Pregnancy complications, such as stillbirth, severe maternal morbidity, preterm birth, and cesarean delivery, also increase risk. Opioid overdose is associated with being houseless, incarcerated, young, unmarried, publicly insured, not graduating high school, co-occurring substance use disorders, and inadequate prenatal care. Legislative changes, such as not classifying OUD in pregnancy as \"child abuse\" and increasing Medicaid reimbursement for Screening, Brief Intervention, and Referral to Treatment programs, are crucial to reducing risk. The impact of race and the influence of co-occurring psychiatric disorders was inconsistently reported.<i>Conclusion:</i> This scoping review identifies significant risk factors for opioid overdose in pregnant and postpartum patients. Improving access through enhanced Medicaid reimbursement, non-punitive reporting policies, and non-stigmatized care are keys to reducing overdose.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"4-13"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cannabis retail store density and county-level mortality from injury in the state of Washington from 2009-2020.","authors":"William C Kerr, Yu Ye","doi":"10.1080/00952990.2024.2436524","DOIUrl":"10.1080/00952990.2024.2436524","url":null,"abstract":"<p><p><i>Background:</i> The state of Washington legalized cannabis for adult use in 2012 and retail stores began to open in 2014 with 31 stores, rising to 447 in 2020. Prior studies have evaluated impacts of legalization on state-level mortality from suicide, motor vehicle accidents and opioid poisonings with mixed findings.<i>Objectives:</i> To estimate relationships between county cannabis retail store density and county mortality rates from suicide, motor vehicle accidents, opioid poisoning, homicide and accidental poisonings.<i>Methods:</i> County mortality data for Washington state (39 counties) from individual death records for the years 2009-2020 used ICD-10 Multiple Cause of Death Files. County-level cannabis retail store counts in Washington were based on cannabis license and sales data. Fixed effect Poisson regression models predicted county-level yearly mortality rates for 2009-2020.<i>Results:</i> Deaths from 2009-20 in Washington were 12,933 (77% men) from suicide, 6761 (71% men) from motor vehicle accidents, 8858 (62% men) from opioid poisoning, 2408 (73% men) from homicide and 11,873 (64% men) from accidental poisonings. Store counts per 10,000 population were negatively associated with accidental poisonings (incidence rate ratio (IRR) of 0.83 (0.73-0.93)) and opioid mortality rates with (IRR of 0.83 (0.70-0.99)). No significant effects were found for motor vehicle accidents, homicide or suicide.<i>Conclusions:</i> County cannabis retail store density in Washington was associated with reduced accidental poisoning and opioid mortality while suicide and motor vehicle accident mortality rates did not appear to change. Results do not support any harmful effects on mortality from cannabis store expansion in Washington counties.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"107-115"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jasmin Choi, Lane Burgette, Katherine Nameth, Katherine E Watkins, Karen Chan Osilla
{"title":"Examining how support persons' buprenorphine attitudes and their communication about substance use impacts patient well-being.","authors":"Jasmin Choi, Lane Burgette, Katherine Nameth, Katherine E Watkins, Karen Chan Osilla","doi":"10.1080/00952990.2024.2417820","DOIUrl":"10.1080/00952990.2024.2417820","url":null,"abstract":"<p><p><i>Background:</i> While social support benefits those in treatment for opioid use disorder, it is unclear how social support impacts patient outcomes.<i>Objectives:</i> This study examines how support person attitudes toward buprenorphine and their communication about substance use are associated with the well-being of patients receiving buprenorphine treatment.<i>Methods:</i> We analyzed cross-sectional baseline data from 219 buprenorphine patients (40% female) and their support persons (72% female). Patients were recruited from five community health centers and asked to nominate a support person. Patient outcomes included symptoms of depression, anxiety, impairment due to substance use, and perceived social support. Support persons predictors included their attitudes toward buprenorphine from four statements (e.g. \"Buprenorphine is just replacing one drug for another\") and communication using two items (e.g. comfort and effectiveness discussing substance use).<i>Results:</i> More stigmatizing attitudes, such as believing patients should quit on their own without medication, were associated with increased patient substance use-related impairment (F = 4.53, <i>p</i> = .01). Effective communication was associated with lower patient depression (F = 10.15, <i>p</i> < .001), anxiety (F = 4.73, <i>p</i> = .001), lower impairment (F = 6.46, <i>p</i> < .001), and higher perceived social support (F = 3.68, <i>p</i> = .007).<i>Conclusions:</i> This study highlights how support person attitudes and communication dynamics significantly affect the mental health and impairment of individuals receiving buprenorphine treatment. Interventions that reduce stigma and promote effective communication between patients and their loved ones could enhance treatment outcomes and overall well-being among patients with OUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"137-147"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Callie L Wang, Lidia Z Meshesha, Jacqueline Woerner, Tatiana D Magri, Minh D Nguyen, Jenni B Teeters
{"title":"Substance use disorders and pharmacotherapies: exploring public knowledge and supportive attitudes.","authors":"Callie L Wang, Lidia Z Meshesha, Jacqueline Woerner, Tatiana D Magri, Minh D Nguyen, Jenni B Teeters","doi":"10.1080/00952990.2025.2450416","DOIUrl":"10.1080/00952990.2025.2450416","url":null,"abstract":"<p><p><i>Background:</i> Despite available and effective prevention and treatment strategies for substance use disorders (SUD), drug overdose deaths in the US remain high. Further, limited public knowledge of SUD pharmacotherapies may contribute to increased stigmatization toward SUD medications and a lack of willingness to help people with SUD.<i>Objectives:</i> This study evaluated knowledge and attitudes about SUD pharmacotherapies and willingness to help people with SUD among a sample of U.S. adults.<i>Method:</i> Participants recruited through Amazon's Mechanical Turk (<i>N</i> = 314; 62.1% male) completed online surveys evaluating knowledge, attitudes, and willingness to help by various demographic factors, history of substance use, and experience with someone with SUD.<i>Results:</i> Results revealed a significant difference in attitudes by race/ethnicity (F(1,307) = 11.85, <i>p</i> < .001). Participants with a personal history of substance use exhibited greater knowledge (F(1,312) = 31.94, <i>p</i> < .001) and willingness to help someone with a SUD (F(1,312) = 7.84, <i>p</i> = .005). Participants with experience with someone with a SUD also exhibited greater knowledge (F(1,311) = 19.42, <i>p</i> < .001) and willingness to help (F(1,311) = 13.63, <i>p</i> < .001).<i>Conclusion:</i> Results emphasize the importance of targeted education to bridge gaps in knowledge, enhance public attitudes, and promote willingness to help individuals with SUD. Utilizing public health strategies that promote empathy, willingness to help, and increase accessibility and acceptance of SUD treatment options, could be potential avenues that ultimately improve outcomes for individuals with SUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"127-136"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The role of negative thinking and catastrophizing in the ordinary experience of withdrawal from substances.","authors":"Paolo Mannelli","doi":"10.1080/00952990.2024.2448717","DOIUrl":"10.1080/00952990.2024.2448717","url":null,"abstract":"","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-3"},"PeriodicalIF":2.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda C Andrade, William U Meyerson, Rick H Hoyle
{"title":"Large-scale longitudinal analysis of the progression of alcohol use among members of a social media platform: an observational study.","authors":"Fernanda C Andrade, William U Meyerson, Rick H Hoyle","doi":"10.1080/00952990.2024.2414324","DOIUrl":"https://doi.org/10.1080/00952990.2024.2414324","url":null,"abstract":"<p><p><i>Background:</i> The large-scale identification of people at risk of transitioning from relatively lower-risk to higher-risk alcohol use (e.g. problem drinking) remains a public health challenge despite advances in the identification of risk and protective factors.<i>Objective:</i> This observational study used machine learning to identify Reddit (social media platform) posting activity associated with transitioning from lower- to higher-risk forms of alcohol use.<i>Methods:</i> We employed bottom-up and top-down approaches to identify lower- and higher-risk alcohol-related subreddits. Using a non-parametric negative control procedure, we estimated each of 10,006 Reddit communities' risk of progression from lower- to higher-risk alcohol-related communities and applied a random forest model to predict progression among individual Reddit members. Eligible Reddit members had posted on Reddit for two or more years before their first post in a lower-risk alcohol-related community and for three or more years after that (<i>N</i> = 4,160).<i>Results:</i> Our methodology identified 42 alcohol-related communities, four of which were suggestive of problem drinking. Five communities were significantly associated with progression. Random forests model's risk scores for individual members correlated with their progression to higher-risk communities at 0.30; the model predicted progression of individual Reddit members with a 0.92 area under the curve.<i>Conclusions:</i> Posting in communities dedicated to other substance use, depression, and occupation in the food service industry was associated with posting activity suggestive of problem drinking 3 years later. Posting activity on Reddit may be used for early detection of people at higher risk of transitioning from lower- to higher-risk forms of alcohol use.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Montserrat Olivares-Costa, María Carolina Fabio, Erwin De la Fuente-Ortega, Paola A Haeger, Ricardo Pautassi
{"title":"New therapeutics for the prevention or amelioration of fetal alcohol spectrum disorders: a narrative review of the preclinical literature.","authors":"Montserrat Olivares-Costa, María Carolina Fabio, Erwin De la Fuente-Ortega, Paola A Haeger, Ricardo Pautassi","doi":"10.1080/00952990.2024.2361442","DOIUrl":"10.1080/00952990.2024.2361442","url":null,"abstract":"<p><p><i>Background:</i> Ethanol consumption during pregnancy induces enduring detrimental effects in the offspring, manifesting as a spectrum of symptoms collectively termed as Fetal Alcohol Spectrum Disorders (FASD). Presently, there is a scarcity of treatments for FASD.<i>Objectives:</i> To analyze current literature, emphasizing evidence derived from preclinical models, that could potentially inform therapeutic interventions for FASD.<i>Methods:</i> A narrative review was conducted focusing on four prospective treatments: nutritional supplements, antioxidants, anti-inflammatory compounds and environmental enrichment. The review also highlights innovative therapeutic strategies applied during early (e.g. folate administration, postnatal days 4-9) or late (e.g. NOX2 inhibitors given after weaning) postnatal stages that resulted in significant improvements in behavioral responses during adolescence (a critical period marked by the emergence of mental health issues in humans).<i>Results:</i> Our findings underscore the value of treatments centered around nutritional supplementation or environmental enrichment, aimed at mitigating oxidative stress and inflammation, implying shared mechanisms in FASD pathogenesis. Moreover, the review spotlights emerging evidence pertaining to the involvement of novel molecular components with potential pharmacological targets (such as NOX2, MCP1/CCR2, PPARJ, and PDE1).<i>Conclusions:</i> Preclinical studies have identified oxidative imbalance and neuroinflammation as relevant pathological mechanisms induced by prenatal ethanol exposure. The relevance of these mechanisms, which exhibit positive feedback loop mechanisms, appear to peak during early development and decreases in adulthood. These findings provide a framework for the future development of therapeutic avenues in the development of specific clinical treatments for FASD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"749-770"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alterations in surface-based brain morphometry in men with opioid use disorder.","authors":"Abhishek Ghosh, Abhishek Verma, Simranjit Kaur, Chirag K Ahuja, Ritu Nehra, Paramjit Singh, Manish Modi, Debasish Basu","doi":"10.1080/00952990.2024.2417220","DOIUrl":"10.1080/00952990.2024.2417220","url":null,"abstract":"<p><p><i>Background:</i> Cortical differences in thickness, folding, and complexity may reflect synaptic pruning and myelination alterations. Individuals with opioid use disorder (OUD) may demonstrate differences in these cortical metrics due to neurodevelopmental aberrations or early opioid exposure.<i>Objectives:</i> We compared the cortical metrics between individuals with OUD and controls. The influence of age and duration of opioid exposure were considered indirect evidence for preexisting or opioid-exposure-based structural aberrations.<i>Methods:</i> Sixty-nine treatment-naïve men with OUD (52 heroin, 17 non-heroin) and 25 age and education-matched non-drug-using male controls were recruited from a treatment center and community, respectively. 3-Tesla Siemens Magnetom Verio scanner and Computational Anatomy Toolbox 12 were used for image acquisition and processing. Cortical parcellation was performed using Destrieux atlas. Surface-based morphometry (SBM) metrics were cortical thickness, sulcal depth, fractal dimension, and gyrification index.<i>Results:</i> Only two cortical areas survived corrections for multiple comparisons: persons with OUD had greater sulcal depth in the right lateral orbital sulcus (<i>p</i> = .0003, Glass's delta = 0.98) and lower gyrification index in the left frontal middle gyrus (<i>p</i> = .0005, Glass's delta = 0.67) than controls. The group-by-age interaction effect on the cortical thickness was non-significant. Lower age of initiation of opioid use was associated with larger cortical thickness in the inferior frontal (<i>r</i> = -0.36, <i>p</i> = .002) and anterior cingulate (<i>r</i> = -0.35, <i>p</i> = .003) regions. Duration of OUD negatively correlated with cortical thickness in frontal and occipital areas (<i>r</i> > -.30, <i>p</i> = .004-.007).<i>Conclusion:</i> Cortical abnormalities may stem from altered synaptic pruning and myelination, possibly due to neurodevelopmental aberrations or early opioid exposure.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"819-830"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virgil Lee Gregory, David A Wilkerson, Samantha N Wolfe-Taylor, Breena L Miller, Alexander D Lipsey
{"title":"Digital cognitive-behavioral therapy for substance use: systematic review and meta-analysis of randomized controlled trials.","authors":"Virgil Lee Gregory, David A Wilkerson, Samantha N Wolfe-Taylor, Breena L Miller, Alexander D Lipsey","doi":"10.1080/00952990.2024.2400934","DOIUrl":"10.1080/00952990.2024.2400934","url":null,"abstract":"<p><p><i>Background:</i> Prior meta-analyses have evaluated digital interventions for alcohol exclusively and alcohol/tobacco combined. These meta-analyses showed positive outcomes pertaining to alcohol and alcohol/tobacco combined. Yet questions remain pertaining to the effect of digital cognitive-behavioral therapy (CBT) on reducing alcohol and drug use.<i>Objectives:</i> The purpose of the meta-analysis was to determine the mean effect size, relative to control groups, of digital CBT, for posttest reductions in drug and/or alcohol use.<i>Methods:</i> The Preferred Reporting Items for Systematic Reviews and Meta-analyses criteria was used to guide this review and meta-analysis. Electronic databases (APA PsycArticles, Academic Search Complete, APA PsycInfo, CINAHL Complete, ERIC, MEDLINE, Psychology and Behavioral Sciences Collection, Social Sciences Full Text, Social Work Abstracts, SocINDEX), clinicaltrials.gov, reference lists were searched. The protocol was registered in PROSPERO (ID#: CRD42023471492). The CBT interventions included cognitive restructuring.<i>Results:</i> All but one of the effect sizes favored digital CBT (from -0.02 to -1.45). After the removal an outlier, a small, significant, random effects model Hedges' <i>g</i> summary effect of -0.23 (95% confidence interval: -0.32, -0.14, <i>p</i> < .0001) showed a reduction in substance use at the posttest, favoring digital CBT relative to the control group. A variety of control conditions were used; however, the effects sizes had minimal heterogeneity (<i>k</i> = 17, <i>I</i><sup>2</sup> = 5.34, <i>Q</i> = 16.9, <i>p</i> = .39). The funnel plot and Egger regression test intercept (0.01, <i>p</i> = .99) lacked publication bias.<i>Conclusion:</i> The meta-analytic findings suggest digital CBT is an efficacious treatment for reducing alcohol and drug use overall.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"771-785"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prerna Varma, Lara DePadilla, Mark É Czeisler, Elizabeth A Rohan, Matthew D Weaver, Stuart F Quan, Rebecca Robbins, Chirag G Patel, Stephanie Melillo, Alexandra Drane, Sarah Stephens Winnay, Rashon I Lane, Charles A Czeisler, Mark E Howard, Shantha M W Rajaratnam, Jennifer L Matjasko
{"title":"Substance use and help seeking as coping behaviors among parents and unpaid caregivers of adults in the United States during the COVID-19 pandemic.","authors":"Prerna Varma, Lara DePadilla, Mark É Czeisler, Elizabeth A Rohan, Matthew D Weaver, Stuart F Quan, Rebecca Robbins, Chirag G Patel, Stephanie Melillo, Alexandra Drane, Sarah Stephens Winnay, Rashon I Lane, Charles A Czeisler, Mark E Howard, Shantha M W Rajaratnam, Jennifer L Matjasko","doi":"10.1080/00952990.2024.2394970","DOIUrl":"10.1080/00952990.2024.2394970","url":null,"abstract":"<p><p><i>Background:</i> During the COVID-19 pandemic, caregiving responsibilities may have been associated with increased substance use.<i>Objectives:</i> To characterize substance use to cope with stress and willingness to seek help among (i) parents, (ii) unpaid caregivers of adults, and (iii) parent-caregivers.<i>Methods:</i> Data were analyzed for 10,444 non-probabilistic internet-based survey respondents of the COVID-19 Outbreak Public Evaluation (COPE) initiative (5227 females, 5217 males). Questions included new or increased substance use, substance use in the past 30 days to cope, insomnia, mental health, and willingness to seek help.<i>Results:</i> Nearly 20% of parents and unpaid caregivers of adults each reported new or increased use of substances to cope with stress or emotions; 65.4% of parent-caregivers endorsed this response. Compared to non-caregivers, all caregiver groups had higher odds of new or increased use of substances, with parent-caregivers showing the largest effect size (aOR: 7.19 (5.87-8.83), <i>p</i> < .001). Parent-caregivers had four times the adjusted odds of using drugs other than cannabis (aOR: 4.01 (3.15-5.09), <i>p</i> < .001) compared to non-caregivers.<i>Conclusions:</i> Caregivers may initiate or increase substance use as a coping strategy when under stress. The higher odds of substance use underscores the importance of efforts to screen for sleep disturbances and adverse mental health symptoms, particularly among parent-caregivers. Clinicians may consider asking patients about family situations more broadly to help identify people who may be experiencing stress related to caregiving and, if indicated, offer treatment to potentially alleviate some of the risks.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"851-863"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}