American Journal of Drug and Alcohol Abuse最新文献

{"title":"Regulation of HDL metabolism in alcohol-associated liver disease: the role of HIF-1α and miR-185 in SR-BI suppression.","authors":"Jiye Zhang, Wenling Mou, Shiru Chen, Zhenting Wu, Shujie Zhang, Ping Liu, Haobo Sun, Hang Zhou, Ying Liu","doi":"10.1080/00952990.2025.2506529","DOIUrl":"https://doi.org/10.1080/00952990.2025.2506529","url":null,"abstract":"<p><p><i>Background:</i> Alcohol-associated liver disease (ALD) results from excessive alcohol consumption, leading to liver damage such as steatosis and inflammation. Hypoxia and altered lipid metabolism contribute to ALD pathogenesis. HIF-1α, a key hypoxia regulator, and miR-185, a microRNA associated with ALD, are potential contributors to the disease.<i>Objectives:</i> To explore how HIF-1α and miR-185 regulate SR-BI and HDL metabolism in ethanol-exposed hepatocytes and their role in ALD-related lipid dysfunction.<i>Methods:</i> HL-7702 cells were treated with ethanol (25-200 mm) or hypoxia (1-2% O₂) for 24-72 hours to identify optimal conditions. miR-185 or HIF-1α inhibitors were used to assess SR-BI expression. Co-localization of HIF-1α and SR-BI was evaluated by immunofluorescence, and high-density lipoprotein cholesterol (HDL-C), which is critical in lipid metabolism, and triglyceride (TG) levels were measured by ELISA.<i>Results:</i> Ethanol exposure reduced cell viability in a dose- and time-dependent manner (200 mm for 72 h reduced viability by 43.7% ± 4.1%, <i>p</i> = .003). Exposure to 1% oxygen for 72 hours was confirmed as the optimal hypoxia model. Ethanol (200 mm) or hypoxia significantly increased HIF-1α (<i>p</i> = .002) and miR-185 expression (<i>p</i> = .001). These changes were accompanied by reduced SR-BI expression and elevated HDL-C and TG levels. miR-185 knockdown restored SR-BI expression (<i>p</i> = .003) and normalized HDL-C (<i>p</i> = .004) and TG levels (<i>p</i> = .005).<i>Conclusions:</i> Ethanol-induced HIF-1α and miR-185 upregulation disrupts HDL metabolism by suppressing SR-BI, impairing hepatic HDL uptake in ALD. Targeting this axis may offer new therapeutic strategies for ALD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemp-derived tetrahydrocannabinol (THC) and kratom related health claims provided by smoke shop employees: a secret shopper study.","authors":"Kirk E Evoy, Sarina Acharya, Michael Bloomfield, Sorina B Torrez, Jordan R Covvey, Matthew Witry","doi":"10.1080/00952990.2025.2502743","DOIUrl":"https://doi.org/10.1080/00952990.2025.2502743","url":null,"abstract":"<p><p><i>Background:</i> US smoke shop prevalence is growing and stores are diversifying products beyond nicotine vape supplies, often selling non-regulated psychoactive substances.<i>Objectives:</i> Investigate health claims and safety information provided by smoke shop employees regarding hemp-derived tetrahydrocannabinol (THC) and kratom.<i>Methods:</i> Secret shopper visits were conducted at 100 San Antonio and Austin, Texas smoke shops. Using scripted questions, shoppers assessed whether the shop sold THC and kratom, what these products could be used for, and adverse effects. Shoppers documented product availability, disease states referenced, health claims made, adverse effects mentioned, and guidance for use related to pregnancy. Descriptive statistics were calculated to characterize shopper reports.<i>Results:</i> THC (100%) and kratom (94%) were routinely stocked by smoke shops. Most employees made at least one health claim regarding THC (50%) or kratom (81%). Claims regarding pain (50%), insomnia (31%), and mental health disorders (27%) were most commonly discussed for THC, while drug withdrawal/cravings (76%), pain (69%), and mental health conditions (31%) were most frequent for kratom. When specifically asked about adverse effects, 22% and 24% of smoke shop employees, respectively, did not disclose any risks about THC or kratom; most others provided minimal information. The most common risks discussed were sedation (36%) and psychiatric (31%) adverse effects for THC, and dependence (59%) and gastrointestinal (24%) adverse effects for kratom.<i>Conclusion:</i> Efforts to develop evidence-based consumer information regarding kratom and hemp-derived THC, improve health information provided by smoke shop employees, and incentivize store owners to devote resources to employee education are needed.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing factors associated with knowledge of Driving Under the Influence (DUI) penalties.","authors":"Zoe Lindenfeld, James Macinko, Jin Yung Bae, Robert Zeithammer, Diana Silver","doi":"10.1080/00952990.2025.2504152","DOIUrl":"https://doi.org/10.1080/00952990.2025.2504152","url":null,"abstract":"<p><p><i>Background:</i> The use of legal sanctions is often framed as a way to deter driving under the influence (DUI). Yet little research has assessed frequent drinkers' knowledge of DUI penalties.<i>Objectives:</i> To assess the general public's knowledge of DUI penalties (an important element of deterrence) in their state and factors associated with more accurate knowledge.<i>Methods:</i> This US-based cross-sectional study used data from a Connect Platform survey of adult drinkers (<i>n</i> = 583, 58.0% male, 41.4% female) that asked their beliefs on the usual DUI fine and jail time penalty in their state, and how much they expected to be charged if imprisoned (jail fee). Responses were compared with data on minimum/maximum DUI penalties that appear in state statutes pertaining to DUI. For fines, responses were considered accurate if within $100 of the penalty on statute, and for jail time, if they matched the penalty on statute. Regression models were used to assess respondent characteristics associated with accurate penalty knowledge.<i>Results:</i> Among respondents, 83.7% and 67.2% underestimated the minimum DUI fine and jail time penalty in their state, respectively, and 8.7% and 19.7% overestimated. Although 75.4% of respondents lived in a state that charged jail fees, less than half were aware of this. No demographic or characteristic was consistently associated with accurate penalty knowledge across regression models (<i>p</i> > .05).<i>Conclusions:</i> The majority of respondents underestimated the DUI penalty in their state and suggest that large-scale campaigns to educate the public on the severity of DUI penalties are warranted.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of alternative income assistance disbursement on substance use disorder treatment adherence among people who use drugs.","authors":"Sukhpreet Klaire, JinCheol Choi, Allison Laing, Lindsey Richardson","doi":"10.1080/00952990.2025.2494112","DOIUrl":"https://doi.org/10.1080/00952990.2025.2494112","url":null,"abstract":"<p><p><i>Background:</i> The synchronized disbursement of income assistance payments is associated with increased drug-related harms and substance use disorder (SUD) treatment interruptions. Desynchronizing and splitting these payments can mitigate escalations in drug use, suggesting that downstream effects on SUD treatment may be impacted as well.<i>Objectives:</i> To understand the effect of desynchronizing and splitting income assistance payments on treatment patterns, including adherence to medications for opioid use disorder (MOUD).<i>Methods:</i> Data came from The Impact of Alternative Social Assistance on Drug Related Harm (TASA) study, conducted in Vancouver, Canada. This parallel arm, multi-group, randomized controlled trial assigned participants for six payment cycles to the synchronized monthly government schedule control or one of two intervention arms receiving payments desynchronized from the government schedule: a \"staggered\" group receiving monthly payments or a \"split & staggered\" group receiving semimonthly payments. Multivariable generalized estimating equations assessed the effect on overall SUD treatment adherence, MOUD adherence, and non-MOUD SUD treatment adherence.<i>Results:</i> Between October 2015 and January 2019, 194 participants were randomized and followed, including 89 (45.8%) women and 83 (42.8%) who self-identified as a person of color. In both intent-to-treat (ITT) and modified per-protocol (MPP) analyses, neither intervention arm was associated with decreased adherence to SUD treatment (ITT staggered arm adjusted odds ratio [AOR] 0.75, 95% confidence interval [CI] 0.36-1.55, split and staggered arm AOR 0.83, 95% CI 0.44-1.57; MPP staggered arm AOR 0.72, 95% CI 0.38-1.39, split and staggered arm AOR 0.89, 95% CI 0.54-1.46), including MOUD and non-MOUD.<i>Conclusions:</i> Alternative income assistance disbursement did not positively impact SUD treatment adherence, contrary to the hypothesis. Changing payment schedules also did not negatively impact SUD treatment adherence, suggesting that changes to payment delivery could be completed without impacting treatment.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early experiences and impacts of a fentanyl powder safer supply program in Vancouver, Canada: a qualitative study.","authors":"Andrew Ivsins, Christy Sutherland, Thomas Kerr, Mary Clare Kennedy","doi":"10.1080/00952990.2025.2497800","DOIUrl":"https://doi.org/10.1080/00952990.2025.2497800","url":null,"abstract":"<p><p><i>Background:</i> North America is experiencing an unrelenting overdose crisis driven by a volatile and toxic unregulated drug supply. Safer supply programs, which provide individuals with pharmaceutical-grade alternatives to the unregulated drug supply, have been implemented in various Canadian jurisdictions. While most programs provide tablet hydromorphone, the Safer Alternatives for Emergency Response (SAFER) program in Vancouver, Canada, offers pharmaceutical-grade fentanyl, including a powder formulation for witnessed consumption.<i>Objectives:</i> To explore early experiences among SAFER program participants receiving powder fentanyl.<i>Methods:</i> Qualitative one-on-one interviews were conducted with 18 (12 men, 6 women) people prescribed fentanyl powder from the SAFER program. Interview coding and analysis involved a team-based approach to identify common themes related to program experiences, focusing on impacts on unregulated drug use.<i>Results:</i> Most (13/18; 72%) participants reported reducing unregulated drug use since program enrollment. This was largely attributed to the SAFER fentanyl powder being effective for managing withdrawal, thereby limiting their need to access street-purchased drugs. Additionally, some participants, particularly those prescribed higher doses, suggested that SAFER fentanyl powder, unlike other safe supply medications, was a suitable alternative to street-purchased fentanyl. Participants also reported reduced overdose risk. Operating hours and dosing challenges were barriers to program engagement contributing to continued unregulated drug use for some.<i>Conclusion:</i> Our findings demonstrate a number of positive outcomes of the SAFER program and suggest that fentanyl safer supply has the potential to play a useful role in addressing the ongoing overdose crisis.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing the forest for the trees: a commentary on 'real-world' e-cigarette use and readiness to stop smoking among adults who smoke.","authors":"Matthew J Carpenter, Elias M Klemperer","doi":"10.1080/00952990.2025.2497798","DOIUrl":"https://doi.org/10.1080/00952990.2025.2497798","url":null,"abstract":"","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-3"},"PeriodicalIF":2.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of mental health and substance use issues on recidivism among youth on probation.","authors":"Jennifer N Stanley, Sarah C DeLucca, Steven Belenko, Angela Robertson","doi":"10.1080/00952990.2025.2491377","DOIUrl":"10.1080/00952990.2025.2491377","url":null,"abstract":"<p><p><i>Background:</i> Justice-involved youth have high rates of mental health and substance use disorders which are linked to re-offending. However, research on the impact of behavioral health issues, especially among those on community supervision, is limited.<i>Objectives:</i> This study examines the effects of co-occurring mental health and substance use indicators on recidivism among youth on probation using data from the JJ-TRIALS multi-site cooperative. We compare hazard rates for recidivism by type of behavioral health indicator.<i>Methods:</i> The sample includes 3,023 female and 9,617 male (<i>N</i> = 12,649) youth who were followed for up to 1,415 days after initial probation referral.<i>Results:</i> Cox proportional hazard models revealed that those with mental health issues only (HR = 1.5, <i>p</i> < .001), substance use only (HR = 1.5, <i>p</i> < .001), and co-occurring conditions (HR = 3.5, <i>p</i> < .001) had a greater recidivism hazard than those with no behavioral health issues. Survival analysis indicated that those with co-occurring indicators had a faster time to recidivism compared to other behavioral health groups. There was a significant interaction between behavioral health status and treatment initiation, particularly for those with substance use (HR = 0.34, <i>p</i> < .001) and co-occurring indicators (HR = 0.89, <i>p</i> = .02).<i>Conclusion:</i> Behavioral health affects recidivism among justice-involved youth. Treatment initiation, while shown to reduce recidivism, may differentially impact reoffending depending on specific behavioral health needs. Findings highlight the need for enhanced assessment and expanded co-occurring treatment and emphasize the importance of matching youth to appropriate community-based, integrated services to improve justice-related outcomes.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid use disorder Cascade of care: defining a taxonomy for measurement.","authors":"Brandy F Henry, Noa Krawczyk, Ashly E Jordan, Chinazo O Cunningham, Pat Lincourt, Shazia Hussain, Charissa Fotinos, Arthur Robin Williams","doi":"10.1080/00952990.2025.2494106","DOIUrl":"https://doi.org/10.1080/00952990.2025.2494106","url":null,"abstract":"<p><p><i>Background:</i> The opioid use disorder Cascade of care (OUD Cascade) is a public health framework used by federal/state/other agencies and researchers to facilitate monitoring and evaluating responses to the opioid epidemic, including surveillance and performance evaluation. As the use of the framework proliferates, there is an urgent need to standardize stage definitions to accurately monitor and improve patient outcomes and to align interpretation of findings across settings.<i>Objectives:</i> Define a taxonomy to uniformly apply the OUD Cascade to improve delivery of OUD services and better compare patient outcomes across settings and populations.<i>Methods:</i> We conducted a narrative review and synthesis focused on research and guidelines defining and measuring four key OUD Cascade stages: OUD identification, service engagement, medication initiation, and retention. Included articles come from peer-reviewed literature and define and/or operationalize OUD Cascade stages and associated measures across six characteristics based on an adaptation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist including: 1) settings, 2) specific population, 3) perspective, 4) time horizon, 5) assumptions, and 6) analytic method.<i>Results:</i> Our review (<i>n</i> = 27 articles) and synthesis provide an overview of how OUD Cascade definitions and framework designs have been variously applied. We found considerable heterogeneity in study approaches for all four OUD Cascade stages. We define a taxonomy to guide future research emphasizing standardized definitions to harmonize efforts across settings. In particular, we emphasize the need for clarity in defining criteria for sample construction (i.e. Identification), clear distinctions between receipt of care services generally (i.e. Engagement) from MOUD Initiation specifically, and Retention definitions that use a 30+ day gap in treatment to define discontinuation.<i>Conclusion:</i> Establishing a shared taxonomy for key terms specifying OUD Cascade stages will help the field advance, compare approaches and results across settings, and improve population-level patient outcomes.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Spanish simultaneous alcohol and cannabis motives measure (S-SMM) and its short form (S-SMM-SF) among young adults.","authors":"Lucía Vélez Pérez, José Carmona Márquez, Bella M González Ponce, Fermín Fernández Calderón","doi":"10.1080/00952990.2025.2484532","DOIUrl":"https://doi.org/10.1080/00952990.2025.2484532","url":null,"abstract":"<p><p><i>Background:</i> Simultaneous Alcohol and Cannabis (SAC) use is associated with greater negative consequences than individual use. Motives to use are robust predictors of alcohol and cannabis consumption, both separately and simultaneously. Despite the recent development of both a SAC motives measure and its short form, no Spanish adaptation is currently available.<i>Objectives:</i> To provide a Spanish adaptation of the full-length and short-form versions of the simultaneous alcohol and cannabis motives measure and to examine its psychometric properties in a sample of young adult SAC users.<i>Methods:</i> A targeted sampling procedure was used to recruit 612 young cannabis users, of whom 479 reported SAC use (18-25 years old [<i>M</i> = 21.01, SD = 2.14]; 36% female). Following adaptation and translation, participants completed the scale, along with measures of frequency of alcohol, cannabis, and simultaneous use, cannabis motives, and alcohol- and cannabis-related negative consequences.<i>Results:</i> Confirmatory factor analyses showed a four-factor structure (conformity, positive effects, calm/coping, and social). Moreover, the results indicated acceptable internal consistency (.70-.88), providing evidence of convergent, discriminant, and predictive validity for most dimensions.<i>Conclusions:</i> The results suggest that both versions of the scale are valuable tools for assessing motives for SAC consumption among young adults. These scales could aid in investigating motives for SAC use and informing interventions to mitigate associated harms.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol administration in studies of human aggression: a methodological review.","authors":"Alexandra N Brockdorf, Amanda E Baildon, Sarah J Gervais, David DiLillo","doi":"10.1080/00952990.2025.2478391","DOIUrl":"https://doi.org/10.1080/00952990.2025.2478391","url":null,"abstract":"<p><p><i>Background:</i> Alcohol administration paradigms are widely used to test the effects of alcohol on human aggression. However, methods used to implement alcohol administration designs can vary considerably, with implications for impact and generalizability.<i>Objectives:</i> This review summarizes and critically evaluates design features of alcohol administration studies on aggression to inform protocol development and provide recommendations for reporting practices.<i>Methods:</i> Ninety-seven studies that employed alcohol administration to study the effects of alcohol on interpersonal aggression were coded for methodological features, including the scope of aggressive behavior and sample characteristics, alcohol administration protocols, and elicitation of alcohol-related expectancies.<i>Results:</i> Alcohol administration studies of aggression have used relatively homogenous samples and aggression paradigms, especially laboratory analogues of alcohol-involved physical aggression. In the alcohol condition, researchers tended to induce relatively high intoxication (mean BrAC = 0.08) using a mixed liquor drink, though drinking and absorption periods relevant for breath alcohol concentration when aggression was assessed were less consistent. Almost all studies with a placebo condition (<i>n</i> = 65 out of 69) included beverage features to enhance alcohol-related expectancies and bolster believability, but only a third told placebo participants they received alcohol. Recommendations for reporting are presented in a checklist.<i>Conclusion:</i> This review identifies several future methodological directions, including greater inclusion of underrepresented individuals and types of aggression (e.g. sexual, intimate partner), consistent reporting of alcohol administration procedures, and evaluation of placebo enhancement strategies. Maximizing the rigor and replicability of these designs is essential for efforts to understand and reduce alcohol-related aggression.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-18"},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}