American Journal of Drug and Alcohol Abuse最新文献

{"title":"HIF-1α/miR-185 axis regulates lipid accumulation and metabolism involved in alcohol-related liver disease in mice.","authors":"Jiye Zhang, Yang Shen, Shichao Xiong, Wenling Mou, Shiru Chen, Zhenting Wu, Haobo Sun, Hang Zhou, Jiehao Zhou, Ying Liu, Yan Zhao","doi":"10.1080/00952990.2025.2507206","DOIUrl":"https://doi.org/10.1080/00952990.2025.2507206","url":null,"abstract":"<p><p><i>Background:</i> Hypoxia is a major driver of alcohol-related liver disease (ARLD), with hypoxia-inducible factor 1-alpha (HIF-1α) central to this response. Emerging evidence suggests HIF-1α regulates hepatic lipid metabolism via microRNA-185 (miR-185), though the mechanism remains unclear.<i>Objectives:</i> This work aims to unravel the molecular mechanisms by which the HIF-1α/miR-185 pathway regulates lipid uptake and transport in ARLD, and to explore its potential as a therapeutic target.<i>Methods:</i> Male C57BL/6J mice were administered a chronic ethanol-containing Lieber-DeCarli liquid diet for six weeks to induce ARLD, along with adeno-associated virus-mediated silencing of HIF-1α. Serum levels of liver function markers and lipid profile components were measured for biochemical analysis. ELISA evaluation was carried out for liver inflammatory markers. Liver sections were evaluated with H&E oil red O staining. HIF-1α, miR-185, scavenger receptor class B type I (SR-BI), and low-density lipoprotein receptor (LDLR) expressions were evaluated using RT-PCR and Western Blot.<i>Results:</i> Chronic alcohol exposure to mice was responsible for inducing liver steatosis, inducing HIF-1α, and increasing miR-185 (<i>p</i> < 0. 05, η² = 0.32). In alcohol-fed wild-type mice, the mRNA and protein levels of SR-BI decreased significantly (<i>p</i> < 0.05, η² = 0.29), while LDLR levels were enhanced (<i>p</i> < .05, η² = 0.25). HIF-1α silencing downregulated LDLR mRNA and protein expression in alcohol-fed mice (<i>p</i> < 0. 05, η² = 0.23).<i>Conclusions:</i>Alcohol-induced activation of the HIF-1α/miR-185 pathway disrupts hepatic lipid metabolism by modulating SR-BI and LDLR transcription, presenting a potential therapeutic target for lipid disorders in ARLD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive effects between pregnancy-related alcohol policies and state spirits availability on infant and maternal outcomes.","authors":"Alex Schulte, Meenakshi S Subbaraman, Guodong Liu, William C Kerr, Pamela J Trangenstein, Sarah C M Roberts","doi":"10.1080/00952990.2025.2503459","DOIUrl":"https://doi.org/10.1080/00952990.2025.2503459","url":null,"abstract":"<p><p><i>Background:</i> Most state policies targeting pregnant people's alcohol use are ineffective, while some broader alcohol availability policies like government monopolies on retail spirits sales are effective. Previous research has not explored interactions of these policies.<i>Objective:</i> Analyze whether there are interactive effects between pregnancy-specific alcohol policies and government monopolies over retail spirits sales on infant and maternal outcomes.<i>Methods:</i> Outcome data were from Merative MarketScan®, a commercial insurance claims database, and included individuals who birthed singletons between 2006 and 2019 (<i>N</i> = 1,432,979 birthing person-infant pairs). We examined interactions between six pregnancy-specific policies and government monopolies. Regression models include (monopolyXpregnancy-specific policy) interaction terms, state and year fixed-effects, state-specific time trends, individual- and state-level controls, and clustering by state.<i>Results:</i> Associations of pregnancy-specific policies were generally stronger, or only present, in monopoly states. However, there was no consistent pattern regarding direction. Conversely, government monopolies consistently related to reduced infant maltreatment, with the largest effect when Priority Treatment for pregnant women policies were also in place [-1.64% (95% CI -1.87, -1.41)]. Protective associations of government monopolies on infant morbidities differed across reporting policies; for example, monopolies were protective without Reporting Requirements for child welfare [-0.28% (95% CI -0.40, -0.17)], but no longer protective with this policy [0.00% (95% CI -0.53, 0.55)].<i>Conclusions:</i> Government monopolies on retail spirits sales generally relate to reduced infant maltreatment and morbidities, although some pregnancy-specific alcohol policies blunt the protective effects of government monopolies. Repealing some ineffective pregnancy-specific policies - e.g. some Reporting Requirements - in monopoly states might improve infant outcomes.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-13"},"PeriodicalIF":2.7,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of HDL metabolism in alcohol-associated liver disease: the role of HIF-1α and miR-185 in SR-BI suppression.","authors":"Jiye Zhang, Wenling Mou, Shiru Chen, Zhenting Wu, Shujie Zhang, Ping Liu, Haobo Sun, Hang Zhou, Ying Liu","doi":"10.1080/00952990.2025.2506529","DOIUrl":"https://doi.org/10.1080/00952990.2025.2506529","url":null,"abstract":"<p><p><i>Background:</i> Alcohol-associated liver disease (ALD) results from excessive alcohol consumption, leading to liver damage such as steatosis and inflammation. Hypoxia and altered lipid metabolism contribute to ALD pathogenesis. HIF-1α, a key hypoxia regulator, and miR-185, a microRNA associated with ALD, are potential contributors to the disease.<i>Objectives:</i> To explore how HIF-1α and miR-185 regulate SR-BI and HDL metabolism in ethanol-exposed hepatocytes and their role in ALD-related lipid dysfunction.<i>Methods:</i> HL-7702 cells were treated with ethanol (25-200 mm) or hypoxia (1-2% O₂) for 24-72 hours to identify optimal conditions. miR-185 or HIF-1α inhibitors were used to assess SR-BI expression. Co-localization of HIF-1α and SR-BI was evaluated by immunofluorescence, and high-density lipoprotein cholesterol (HDL-C), which is critical in lipid metabolism, and triglyceride (TG) levels were measured by ELISA.<i>Results:</i> Ethanol exposure reduced cell viability in a dose- and time-dependent manner (200 mm for 72 h reduced viability by 43.7% ± 4.1%, <i>p</i> = .003). Exposure to 1% oxygen for 72 hours was confirmed as the optimal hypoxia model. Ethanol (200 mm) or hypoxia significantly increased HIF-1α (<i>p</i> = .002) and miR-185 expression (<i>p</i> = .001). These changes were accompanied by reduced SR-BI expression and elevated HDL-C and TG levels. miR-185 knockdown restored SR-BI expression (<i>p</i> = .003) and normalized HDL-C (<i>p</i> = .004) and TG levels (<i>p</i> = .005).<i>Conclusions:</i> Ethanol-induced HIF-1α and miR-185 upregulation disrupts HDL metabolism by suppressing SR-BI, impairing hepatic HDL uptake in ALD. Targeting this axis may offer new therapeutic strategies for ALD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemp-derived tetrahydrocannabinol (THC) and kratom related health claims provided by smoke shop employees: a secret shopper study.","authors":"Kirk E Evoy, Sarina Acharya, Michael Bloomfield, Sorina B Torrez, Jordan R Covvey, Matthew Witry","doi":"10.1080/00952990.2025.2502743","DOIUrl":"https://doi.org/10.1080/00952990.2025.2502743","url":null,"abstract":"<p><p><i>Background:</i> US smoke shop prevalence is growing and stores are diversifying products beyond nicotine vape supplies, often selling non-regulated psychoactive substances.<i>Objectives:</i> Investigate health claims and safety information provided by smoke shop employees regarding hemp-derived tetrahydrocannabinol (THC) and kratom.<i>Methods:</i> Secret shopper visits were conducted at 100 San Antonio and Austin, Texas smoke shops. Using scripted questions, shoppers assessed whether the shop sold THC and kratom, what these products could be used for, and adverse effects. Shoppers documented product availability, disease states referenced, health claims made, adverse effects mentioned, and guidance for use related to pregnancy. Descriptive statistics were calculated to characterize shopper reports.<i>Results:</i> THC (100%) and kratom (94%) were routinely stocked by smoke shops. Most employees made at least one health claim regarding THC (50%) or kratom (81%). Claims regarding pain (50%), insomnia (31%), and mental health disorders (27%) were most commonly discussed for THC, while drug withdrawal/cravings (76%), pain (69%), and mental health conditions (31%) were most frequent for kratom. When specifically asked about adverse effects, 22% and 24% of smoke shop employees, respectively, did not disclose any risks about THC or kratom; most others provided minimal information. The most common risks discussed were sedation (36%) and psychiatric (31%) adverse effects for THC, and dependence (59%) and gastrointestinal (24%) adverse effects for kratom.<i>Conclusion:</i> Efforts to develop evidence-based consumer information regarding kratom and hemp-derived THC, improve health information provided by smoke shop employees, and incentivize store owners to devote resources to employee education are needed.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing factors associated with knowledge of Driving Under the Influence (DUI) penalties.","authors":"Zoe Lindenfeld, James Macinko, Jin Yung Bae, Robert Zeithammer, Diana Silver","doi":"10.1080/00952990.2025.2504152","DOIUrl":"https://doi.org/10.1080/00952990.2025.2504152","url":null,"abstract":"<p><p><i>Background:</i> The use of legal sanctions is often framed as a way to deter driving under the influence (DUI). Yet little research has assessed frequent drinkers' knowledge of DUI penalties.<i>Objectives:</i> To assess the general public's knowledge of DUI penalties (an important element of deterrence) in their state and factors associated with more accurate knowledge.<i>Methods:</i> This US-based cross-sectional study used data from a Connect Platform survey of adult drinkers (<i>n</i> = 583, 58.0% male, 41.4% female) that asked their beliefs on the usual DUI fine and jail time penalty in their state, and how much they expected to be charged if imprisoned (jail fee). Responses were compared with data on minimum/maximum DUI penalties that appear in state statutes pertaining to DUI. For fines, responses were considered accurate if within $100 of the penalty on statute, and for jail time, if they matched the penalty on statute. Regression models were used to assess respondent characteristics associated with accurate penalty knowledge.<i>Results:</i> Among respondents, 83.7% and 67.2% underestimated the minimum DUI fine and jail time penalty in their state, respectively, and 8.7% and 19.7% overestimated. Although 75.4% of respondents lived in a state that charged jail fees, less than half were aware of this. No demographic or characteristic was consistently associated with accurate penalty knowledge across regression models (<i>p</i> > .05).<i>Conclusions:</i> The majority of respondents underestimated the DUI penalty in their state and suggest that large-scale campaigns to educate the public on the severity of DUI penalties are warranted.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early experiences and impacts of a fentanyl powder safer supply program in Vancouver, Canada: a qualitative study.","authors":"Andrew Ivsins, Christy Sutherland, Thomas Kerr, Mary Clare Kennedy","doi":"10.1080/00952990.2025.2497800","DOIUrl":"https://doi.org/10.1080/00952990.2025.2497800","url":null,"abstract":"<p><p><i>Background:</i> North America is experiencing an unrelenting overdose crisis driven by a volatile and toxic unregulated drug supply. Safer supply programs, which provide individuals with pharmaceutical-grade alternatives to the unregulated drug supply, have been implemented in various Canadian jurisdictions. While most programs provide tablet hydromorphone, the Safer Alternatives for Emergency Response (SAFER) program in Vancouver, Canada, offers pharmaceutical-grade fentanyl, including a powder formulation for witnessed consumption.<i>Objectives:</i> To explore early experiences among SAFER program participants receiving powder fentanyl.<i>Methods:</i> Qualitative one-on-one interviews were conducted with 18 (12 men, 6 women) people prescribed fentanyl powder from the SAFER program. Interview coding and analysis involved a team-based approach to identify common themes related to program experiences, focusing on impacts on unregulated drug use.<i>Results:</i> Most (13/18; 72%) participants reported reducing unregulated drug use since program enrollment. This was largely attributed to the SAFER fentanyl powder being effective for managing withdrawal, thereby limiting their need to access street-purchased drugs. Additionally, some participants, particularly those prescribed higher doses, suggested that SAFER fentanyl powder, unlike other safe supply medications, was a suitable alternative to street-purchased fentanyl. Participants also reported reduced overdose risk. Operating hours and dosing challenges were barriers to program engagement contributing to continued unregulated drug use for some.<i>Conclusion:</i> Our findings demonstrate a number of positive outcomes of the SAFER program and suggest that fentanyl safer supply has the potential to play a useful role in addressing the ongoing overdose crisis.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Spanish simultaneous alcohol and cannabis motives measure (S-SMM) and its short form (S-SMM-SF) among young adults.","authors":"Lucía Vélez Pérez, José Carmona Márquez, Bella M González Ponce, Fermín Fernández Calderón","doi":"10.1080/00952990.2025.2484532","DOIUrl":"https://doi.org/10.1080/00952990.2025.2484532","url":null,"abstract":"<p><p><i>Background:</i> Simultaneous Alcohol and Cannabis (SAC) use is associated with greater negative consequences than individual use. Motives to use are robust predictors of alcohol and cannabis consumption, both separately and simultaneously. Despite the recent development of both a SAC motives measure and its short form, no Spanish adaptation is currently available.<i>Objectives:</i> To provide a Spanish adaptation of the full-length and short-form versions of the simultaneous alcohol and cannabis motives measure and to examine its psychometric properties in a sample of young adult SAC users.<i>Methods:</i> A targeted sampling procedure was used to recruit 612 young cannabis users, of whom 479 reported SAC use (18-25 years old [<i>M</i> = 21.01, SD = 2.14]; 36% female). Following adaptation and translation, participants completed the scale, along with measures of frequency of alcohol, cannabis, and simultaneous use, cannabis motives, and alcohol- and cannabis-related negative consequences.<i>Results:</i> Confirmatory factor analyses showed a four-factor structure (conformity, positive effects, calm/coping, and social). Moreover, the results indicated acceptable internal consistency (.70-.88), providing evidence of convergent, discriminant, and predictive validity for most dimensions.<i>Conclusions:</i> The results suggest that both versions of the scale are valuable tools for assessing motives for SAC consumption among young adults. These scales could aid in investigating motives for SAC use and informing interventions to mitigate associated harms.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol administration in studies of human aggression: a methodological review.","authors":"Alexandra N Brockdorf, Amanda E Baildon, Sarah J Gervais, David DiLillo","doi":"10.1080/00952990.2025.2478391","DOIUrl":"https://doi.org/10.1080/00952990.2025.2478391","url":null,"abstract":"<p><p><i>Background:</i> Alcohol administration paradigms are widely used to test the effects of alcohol on human aggression. However, methods used to implement alcohol administration designs can vary considerably, with implications for impact and generalizability.<i>Objectives:</i> This review summarizes and critically evaluates design features of alcohol administration studies on aggression to inform protocol development and provide recommendations for reporting practices.<i>Methods:</i> Ninety-seven studies that employed alcohol administration to study the effects of alcohol on interpersonal aggression were coded for methodological features, including the scope of aggressive behavior and sample characteristics, alcohol administration protocols, and elicitation of alcohol-related expectancies.<i>Results:</i> Alcohol administration studies of aggression have used relatively homogenous samples and aggression paradigms, especially laboratory analogues of alcohol-involved physical aggression. In the alcohol condition, researchers tended to induce relatively high intoxication (mean BrAC = 0.08) using a mixed liquor drink, though drinking and absorption periods relevant for breath alcohol concentration when aggression was assessed were less consistent. Almost all studies with a placebo condition (<i>n</i> = 65 out of 69) included beverage features to enhance alcohol-related expectancies and bolster believability, but only a third told placebo participants they received alcohol. Recommendations for reporting are presented in a checklist.<i>Conclusion:</i> This review identifies several future methodological directions, including greater inclusion of underrepresented individuals and types of aggression (e.g. sexual, intimate partner), consistent reporting of alcohol administration procedures, and evaluation of placebo enhancement strategies. Maximizing the rigor and replicability of these designs is essential for efforts to understand and reduce alcohol-related aggression.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-18"},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent stress avoidance influences cue-induced heroin seeking and chaperonin gene expression in the dorsal striatum of adult female rats.","authors":"Kassandra Looschen, Ann Jeffers, Songjukta Chakraborty, Colin Salisbury, Anastasia Dodge, Mason Hochstetler, Swarup Mitra","doi":"10.1080/00952990.2025.2469793","DOIUrl":"https://doi.org/10.1080/00952990.2025.2469793","url":null,"abstract":"<p><p><i>Background:</i> Females remain underrepresented in opioid use disorder (OUD) research, particularly regarding dorsal striatal neuroadaptations. Chaperonins seem to play a role in opioid-induced neural plasticity, yet their contribution to OUD-related changes in the dorsal striatum (DS) remains poorly understood. Given known sex differences in opioid sensitivity, it is important to determine how chaperonin expression contributes to OUD-related adaptations in females.<i>Objective:</i> To investigate how stressor controllability during adolescence influences heroin self-administration (SA) and responses to drug-paired cues in adult female rats, focusing on differential gene expression of chaperonins in the DS.<i>Methods:</i> Female rats were exposed to stress avoidance training during adolescence. These rats underwent, in adulthood, heroin SA followed by cue-induced seeking tests after early and prolonged abstinence.<i>Results:</i> Heroin intake during SA was similar between stress-avoiding and stress-naïve females (<i>n</i> = 8/group, <i>p</i> = .89). However, stress-avoiding females exhibited reduced drug-seeking behavior in response to drug cues at 14 days of abstinence compared to controls (<i>p</i> < .05; d = 0.99), suggesting a protective effect of stressor controllability. qPCR showed that the gene expression of Hspa5, a heat shock protein, was elevated in the dorsolateral striatum (DLS) of stress-avoiding females (<i>p</i> < .05; Cohen d > 1.0). Hspb1 gene expression was upregulated in the dorsomedial striatum (DMS) of stress-avoiding females (<i>p</i> < .05; d > 1.0).<i>Conclusion:</i> These findings suggest that chaperonin dysregulation links opioid exposure and stress avoidance conditions. Increased Hspa5 in the DLS and Hspb1 in the DMS may contribute to the observed behavioral differences supporting further preclinical investigation with clinical implications for stress and OUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"At least four groups of kratom consumers in the United States: latent-class analysis of motivations for kratom use.","authors":"Katherine Hill, Jeffrey M Rogers, Oliver Grundmann, David H Epstein, Kirsten E Smith","doi":"10.1080/00952990.2024.2414319","DOIUrl":"10.1080/00952990.2024.2414319","url":null,"abstract":"<p><p><i>Background:</i> Kratom is a plant with alkaloids acting at opioid, serotonergic, adrenergic, and other receptors. Consumers report numerous use motivations.<i>Objectives:</i> To distinguish subgroups of kratom consumers by kratom-use motivations using latent-class analysis.<i>Methods:</i> From July to November 2022, we utilized convenience sampling and surveyed regular kratom consumers (<i>n</i> = 395, 38.1 years (SD 11.2), 54.9% male, 81.3% White) regarding demographics, lifetime and past-year substance use and preferences, substance use disorder history, healthcare barriers, kratom-use motivations, and general health. We used latent-class analysis to identify subgroups by use motivation and calculated conditional probabilities (P_c) for variables in each class.<i>Results:</i> A four-class model best fit our data. The largest class (32.4%) was characterized by the use of kratom for self-treatment of chronic pain (P_c = .91). The smallest class (19.2%) also reported using kratom for self-treatment, but usually as a long-term replacement for other substances (P_c = .75). The other two classes (24.8% and 23.5%) reported using kratom for management of anxiety (P_c = .87-.95) and depressive symptoms (P_c = .61-.89) and for recreation (P_c = .56- .86). These were distinguished from one another by probability of at least moderate kratom use disorder (P_c = .17 vs. .53), with greater probability observed in the class with greater anxiety (P_c = .13 vs. .50) and depressive (P_c = .34 vs. .82) symptom severity and more likely recreational use motivation (P_c = .56 vs. .86).<i>Conclusion:</i> Kratom consumers can be classified by their use motivations. As with other psychoactive substances, the range of motivations is consistent with the range of likely effects. It is not yet clear whether some motivations might indicate the risk of problems.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"191-203"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}