Andy C Dean, Daicia Allen, Megan McClintick, Jean-Baptiste Pochon, Dara Ghahremani, Mark A Mandelkern, Edythe D London
{"title":"Dopamine D2/D3 receptor availability and working memory in stimulant use disorder.","authors":"Andy C Dean, Daicia Allen, Megan McClintick, Jean-Baptiste Pochon, Dara Ghahremani, Mark A Mandelkern, Edythe D London","doi":"10.1080/00952990.2025.2534809","DOIUrl":"https://doi.org/10.1080/00952990.2025.2534809","url":null,"abstract":"<p><p><i>Background:</i> Dopaminergic neurochemical markers are associated with working memory performance in healthy participants and patients with schizophrenia. Individuals with stimulant use disorder have below-control levels of dopaminergic markers, such as striatal D2-type receptor (D2/3 R) availability (i.e. D2 + D3 subtypes), and they underperform healthy controls on tests of working memory.<i>Objectives:</i> For consideration in the design of treatments for stimulant use disorder, we tested whether working memory and D2/3 R availability are related in this population.<i>Methods:</i> Eighty-four adults with stimulant use disorder at varying lengths of abstinence (74 with methamphetamine use disorder, 10 with cocaine use disorder; 61/23 male/female) and 47 control subjects (26/21 male/female) completed the Spatial Capacity Delayed Response Task (SCAP), a test of working memory. In the stimulant group only, a subset (<i>n</i> = 52) underwent positron emission tomography (PET) using the D2/3 R ligand [<sup>18</sup>F] fallypride. Correlation between SCAP performance and D2/3 R availability was tested in bilateral cortical regions of interest previously associated with working memory (frontal, parietal, insular, and cingulate).<i>Results:</i> Controlling for demographics and estimated intelligence, participants in the stimulant group underperformed the control group on the SCAP (F(1, 125) = 5.58, <i>p</i> < .05). In the subset of the stimulant group who received PET, SCAP performance was positively related to D2/3 R availability in the cingulate cortex (β = 0.43, <i>p</i> < .013, Bonferroni corrected).<i>Conclusion:</i> The findings suggest that the weakness in working memory in participants who use stimulants reflects a deficit in cortical D2/3 R signaling. Strategies to augment cortical D2/3 R signaling may enhance cognitive function to improve treatment response.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.6,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Visuo-spatial learning and memory deficits in C57BL/6 mice following postnatal ethanol exposure.","authors":"Ilknur Dursun, Birsen Elibol","doi":"10.1080/00952990.2025.2526114","DOIUrl":"https://doi.org/10.1080/00952990.2025.2526114","url":null,"abstract":"<p><p><i>Background:</i> Postnatal alcohol exposure impairs the development of the central nervous system, including the visual system. The behavioral consequences of such exposure on visual function remain poorly understood.<i>Objectives:</i> In this study, we investigated the effects of postnatal ethanol exposure on visuospatial learning and memory in C57BL/6 mice.<i>Methods:</i> Ethanol (3.0 g/kg) was administered via intubation on postnatal days 3-20. Controls received intubation only or no intervention. Pups were assigned to alcohol-treated (A, <i>n</i> = 11), intubation control (IC, <i>n</i> = 11), or non-intubated control (C, <i>n</i> = 9) groups. At three months, mice underwent the Novel Object Recognition (NOR) test and a visual water task. The NOR test measured recognition memory and exploratory behavior. The visual water task assessed visual acuity using sinusoidal gratings presented on monitors. Mice were trained over 17 days to associate a grating with a hidden platform, and visual acuity thresholds were determined based on performance at varying spatial frequencies.<i>Results:</i> Alcohol-exposed mice showed significant deficits in recognition memory and visual acuity. No group differences in body weight were observed. However, alcohol-treated mice displayed reduced exploration of novel objects (<i>p</i> = .0085, R<sup>2</sup> = 0.29) and lower visual acuity thresholds at higher spatial frequencies (<i>p</i> = .048, R<sup>2</sup> = 0.24).<i>Conclusion:</i> These findings demonstrate that early postnatal alcohol exposure can lead to lasting impairments in visual-cognitive functions. Given their similarity to deficits seen in children with Fetal Alcohol Spectrum Disorders (FASD), our results suggest the importance of early behavioral and visual assessments in children with suspected prenatal or early postnatal alcohol exposure.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-11"},"PeriodicalIF":2.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mina M Rizk, Barbara Stanley, Tse-Hwei Choo, Martina Pavlicova, Jennifer M Scodes, John Rotrosen, Edward V Nunes
{"title":"Suicidal ideation in adults with opioid use disorder treated with buprenorphine-naloxone versus extended-release naltrexone.","authors":"Mina M Rizk, Barbara Stanley, Tse-Hwei Choo, Martina Pavlicova, Jennifer M Scodes, John Rotrosen, Edward V Nunes","doi":"10.1080/00952990.2025.2524110","DOIUrl":"10.1080/00952990.2025.2524110","url":null,"abstract":"<p><p><i>Background:</i> Depression and suicidal ideation are prevalent in patients with opioid use disorder (OUD).<i>Objectives:</i> This study examined changes in suicidal ideation during OUD treatment with buprenorphine-naloxone or extended-release naltrexone.<i>Methods:</i> 570 adults with OUD (29.6% female) were recruited into a National Drug Abuse Clinical Trials Network randomized trial (NCT02032433) comparing extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X:BOT). Suicidal ideation was assessed at baseline and regular intervals over 24 weeks using continuous self-reported and binary clinician-rated measures from the Concise Health Risk Tracking-Self Report and the Hamilton Depression Rating Scale, respectively. A mixed-effects model was used to assess the association between continuous outcome self-reported suicidal ideation and treatment over time while adjusted for baseline suicidal ideation.<i>Results:</i> Continuous self-report suicidal ideation scores decreased in both groups with a significant time-by-treatment interaction indicating that the treatment effect differed over time (F<sub>(11, 3497)</sub> = 1.81, <i>p</i> = .0464). Scores were significantly lower in the buprenorphine group only in weeks 1 and 3 and when averaged across weeks 1-4. Binary clinician-rated suicidal ideation dropped from 15 (5.25%) and 12 (4.24%) at baseline, to 5 (1.89%) and 3 (1.49%) at week 1, for buprenorphine and naltrexone groups, respectively.<i>Conclusion:</i> OUD treatment with extended-release naltrexone or buprenorphine-naloxone was associated with suicidal ideation reductions from the first week. Suicidal ideation was lower with buprenorphine-naloxone in the first 4 weeks, with no significant differences thereafter. Despite overall low suicidal ideation scores and modest differences, these findings suggest beneficial effects of both treatments in individuals with OUD and mild baseline suicidality.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan P Caulkins, Samantha Pérez-Dávila, Beau Kilmer, Justin Poser, Peter Reuter
{"title":"Historical and contextual variation in daily opioid consumption rates: implications for supply control, service delivery, and research.","authors":"Jonathan P Caulkins, Samantha Pérez-Dávila, Beau Kilmer, Justin Poser, Peter Reuter","doi":"10.1080/00952990.2025.2504147","DOIUrl":"https://doi.org/10.1080/00952990.2025.2504147","url":null,"abstract":"<p><p><i>Background:</i> Illegal opioids can create substantial harms, but the extent depends on multiple factors, including the amount consumed.<i>Objectives:</i> To examine how consumption varies across time and context, with implications for treatment and drug policy.<i>Methods:</i> We searched EBSCOhost and PubMed for literature on individuals: (1) not-in-treatment and purchasing from illegal markets, (2) reporting pre-treatment use at treatment intake, and (3) with opioid use disorder (OUD) receiving medically supplied opioids. A total of 135 articles were deemed relevant.<i>Results:</i> Average consumption intensities vary enormously, from below 100 morphine milligram equivalents (MME) per day for use outside of treatment where prices are high, to ~600 MME in typical illegal markets, and 1,100-1,800 MME per day when supply is free, as in heroin assisted treatment and injectable hydromorphone treatment. MME in methadone programs (190-460) is less than in the traditional British heroin prescribing system (600-1,300). Intensities tended to be higher in recent times, whereas the prices have been lower. Studies during the fentanyl era suggest MMEs per day may be much higher than in the past.<i>Conclusion:</i> The adaptability of consumption has several potential implications. Expansions in supply could have greater effects on quantity consumed than on prevalence. Treatment protocols and overdose prevention strategies may need to adjust for higher baseline consumption. Furthermore, assumptions about health harms from long-term use may need revisiting if they are predicated on lower, historical consumption intensities. These findings are caveated by limitations in reporting of data and variations in methodologies. Hence, greater investments in monitoring consumption intensities are warranted.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-24"},"PeriodicalIF":2.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kassandra Looschen, Ann Jeffers, Songjukta Chakraborty, Colin Salisbury, Anastasia Dodge, Mason Hochstetler, Swarup Mitra
{"title":"Adolescent stress avoidance influences cue-induced heroin seeking and chaperonin gene expression in the dorsal striatum of adult female rats.","authors":"Kassandra Looschen, Ann Jeffers, Songjukta Chakraborty, Colin Salisbury, Anastasia Dodge, Mason Hochstetler, Swarup Mitra","doi":"10.1080/00952990.2025.2469793","DOIUrl":"10.1080/00952990.2025.2469793","url":null,"abstract":"<p><p><i>Background:</i> Females remain underrepresented in opioid use disorder (OUD) research, particularly regarding dorsal striatal neuroadaptations. Chaperonins seem to play a role in opioid-induced neural plasticity, yet their contribution to OUD-related changes in the dorsal striatum (DS) remains poorly understood. Given known sex differences in opioid sensitivity, it is important to determine how chaperonin expression contributes to OUD-related adaptations in females.<i>Objective:</i> To investigate how stressor controllability during adolescence influences heroin self-administration (SA) and responses to drug-paired cues in adult female rats, focusing on differential gene expression of chaperonins in the DS.<i>Methods:</i> Female rats were exposed to stress avoidance training during adolescence. These rats underwent, in adulthood, heroin SA followed by cue-induced seeking tests after early and prolonged abstinence.<i>Results:</i> Heroin intake during SA was similar between stress-avoiding and stress-naïve females (<i>n</i> = 8/group, <i>p</i> = .89). However, stress-avoiding females exhibited reduced drug-seeking behavior in response to drug cues at 14 days of abstinence compared to controls (<i>p</i> < .05; d = 0.99), suggesting a protective effect of stressor controllability. qPCR showed that the gene expression of Hspa5, a heat shock protein, was elevated in the dorsolateral striatum (DLS) of stress-avoiding females (<i>p</i> < .05; Cohen d > 1.0). Hspb1 gene expression was upregulated in the dorsomedial striatum (DMS) of stress-avoiding females (<i>p</i> < .05; d > 1.0).<i>Conclusion:</i> These findings suggest that chaperonin dysregulation links opioid exposure and stress avoidance conditions. Increased Hspa5 in the DLS and Hspb1 in the DMS may contribute to the observed behavioral differences supporting further preclinical investigation with clinical implications for stress and OUD.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine Hill, Jeffrey M Rogers, Oliver Grundmann, David H Epstein, Kirsten E Smith
{"title":"At least four groups of kratom consumers in the United States: latent-class analysis of motivations for kratom use.","authors":"Katherine Hill, Jeffrey M Rogers, Oliver Grundmann, David H Epstein, Kirsten E Smith","doi":"10.1080/00952990.2024.2414319","DOIUrl":"10.1080/00952990.2024.2414319","url":null,"abstract":"<p><p><i>Background:</i> Kratom is a plant with alkaloids acting at opioid, serotonergic, adrenergic, and other receptors. Consumers report numerous use motivations.<i>Objectives:</i> To distinguish subgroups of kratom consumers by kratom-use motivations using latent-class analysis.<i>Methods:</i> From July to November 2022, we utilized convenience sampling and surveyed regular kratom consumers (<i>n</i> = 395, 38.1 years (SD 11.2), 54.9% male, 81.3% White) regarding demographics, lifetime and past-year substance use and preferences, substance use disorder history, healthcare barriers, kratom-use motivations, and general health. We used latent-class analysis to identify subgroups by use motivation and calculated conditional probabilities (P<sub>c</sub>) for variables in each class.<i>Results:</i> A four-class model best fit our data. The largest class (32.4%) was characterized by the use of kratom for self-treatment of chronic pain (P<sub>c</sub> = .91). The smallest class (19.2%) also reported using kratom for self-treatment, but usually as a long-term replacement for other substances (P<sub>c</sub> = .75). The other two classes (24.8% and 23.5%) reported using kratom for management of anxiety (P<sub>c</sub> = .87-.95) and depressive symptoms (P<sub>c</sub> = .61-.89) and for recreation (P<sub>c</sub> = .56- .86). These were distinguished from one another by probability of at least moderate kratom use disorder (P<sub>c</sub> = .17 vs. .53), with greater probability observed in the class with greater anxiety (P<sub>c</sub> = .13 vs. .50) and depressive (P<sub>c</sub> = .34 vs. .82) symptom severity and more likely recreational use motivation (P<sub>c</sub> = .56 vs. .86).<i>Conclusion:</i> Kratom consumers can be classified by their use motivations. As with other psychoactive substances, the range of motivations is consistent with the range of likely effects. It is not yet clear whether some motivations might indicate the risk of problems.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"191-203"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgia O Elliott, Gavin N Petrie, Sara L Kroll, Daniel J O Roche, Leah M Mayo
{"title":"Changes in peripheral endocannabinoid levels in substance use disorders: a review of clinical evidence.","authors":"Georgia O Elliott, Gavin N Petrie, Sara L Kroll, Daniel J O Roche, Leah M Mayo","doi":"10.1080/00952990.2025.2456499","DOIUrl":"10.1080/00952990.2025.2456499","url":null,"abstract":"<p><p><i>Background:</i> The endocannabinoid (eCB) system is a key modulator of stress and reward and is impacted by alcohol and drug use. Recently, the eCB system has been highlighted as a potential novel target in the treatment of substance use disorders (SUDs).<i>Objectives:</i> Understanding how chronic substance use impacts the function of the eCB system can provide a mechanistic rationale for targeting this system in the treatment of SUDs.<i>Methods:</i> A comprehensive review of studies assessing concentrations of eCB ligands N-arachidonoyl ethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG) in individuals with a SUD diagnosis was performed using all EBSCO databases, PubMed, and Google Scholar. Methods and results related to eCB concentrations, diagnosis, and other factors (e.g. treatment status) were extracted from papers written in English and published in peer-reviewed journals before May 22, 2024.<i>Results:</i> Fifteen studies were reviewed; three in alcohol use disorder (AUD), three in cannabis use disorder (CUD), four in cocaine use disorder, one in opioid use disorder (OUD) and four across SUDs. Generally, AEA concentrations were usually, but not always, increased in AUD, CUD, OUD, and cocaine use disorder. 2-AG concentrations were measured less often but were increased in CUD and decreased in cocaine use disorder.<i>Conclusions:</i> Studies generally support the hypothesis that chronic substance use can impact eCB levels, most often with increased AEA and decreased (or not quantified) 2-AG concentrations, though results were often conflicting. Variability in methodology and study design may limit generalizability across studies.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"152-164"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ai Bo, Alejandro Martinez, Jieni Zhou, Daniel Bauer, Patrece L Joseph, Trenette Clark Goings
{"title":"Age patterns and predictors of cannabis initiation among biracial and monoracial U.S. youth.","authors":"Ai Bo, Alejandro Martinez, Jieni Zhou, Daniel Bauer, Patrece L Joseph, Trenette Clark Goings","doi":"10.1080/00952990.2025.2461520","DOIUrl":"10.1080/00952990.2025.2461520","url":null,"abstract":"<p><p><i>Background:</i> Understanding cannabis initiation is essential for effective prevention but remains understudied, especially for biracial youth who are disproportionately affected by substance use.<i>Objectives:</i> This study examined age patterns and predictors of cannabis initiation across eight monoracial and biracial groups and explored whether predictor effects varied by age, racialized group, and sex.<i>Methods:</i> Add Health data (<i>n</i> = 12,941, 50% male, baseline mean age = 15.5) were analyzed using discrete-time survival analyses to estimate cannabis initiation probabilities from ages 10-24 by age, racialized group, and other predictors.<i>Results:</i> Cannabis initiation probability followed a quadratic age pattern, increasing from age 10-16 and declining thereafter, with differences by racialized group (<i>p</i> < .05). The highest probabilities of new initiations (at age 16) ranged from lowest to highest as follows: Asian (0.08), Black (0.10), Hispanic (White) (0.12), White (0.15), Biracial White-Indigenous (0.16), Indigenous (0.18), Biracial White-Black (0.19), and Biracial White-Asian (0.25). Age- and race-varying effects were found for peer substance use and parental control (joint Wald test, <i>p</i> < .05). Specifically, peer substance use was positively associated with cannabis initiation during adolescence, peaking in mid-adolescence, with stronger effects for Biracial White-Black and Biracial White-Asian youth than their monoracial peers. The effects of parental control showed complex, group-specific patterns. Family support and religiosity slightly lowered cannabis initiation across racialized groups.<i>Conclusion:</i> These findings highlight distinct cannabis initiation patterns across racialized groups, along with variations in the effects of peer substance use and parental control by age and racialized group.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"225-236"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sierra Castedo de Martell, Margaret Brannon Moore, Hannah Wang, Lori Holleran Steiker, J Michael Wilkerson, Nalini Ranjit, Sheryl A McCurdy, H Shelton Brown
{"title":"The cost-effectiveness of long-term post-treatment peer recovery support services in the United States.","authors":"Sierra Castedo de Martell, Margaret Brannon Moore, Hannah Wang, Lori Holleran Steiker, J Michael Wilkerson, Nalini Ranjit, Sheryl A McCurdy, H Shelton Brown","doi":"10.1080/00952990.2024.2406251","DOIUrl":"10.1080/00952990.2024.2406251","url":null,"abstract":"<p><p><i>Background:</i> Peer recovery support services (PRSS) have been widely adopted across a variety of settings, but little is known about their economic impact.<i>Objectives:</i> To conduct a cost-effectiveness analysis of long-term, PRSS delivered after specialty substance use disorder (SUD) treatment (post-treatment), and to describe the development of a free, web-based cost-effectiveness calculator based on this analysis.<i>Methods:</i> Using publicly available data from a variety of sources, post-treatment PRSS were compared to specialty SUD treatment from the societal (broad perspective including costs like participant time) and health systems perspectives (only costs borne by health system), and in terms of quality-adjusted life years (QALYs) added and people in recovery. Whenever possible, 2019 data were used to avoid the impacts of COVID-19. Standard willingness-to-pay thresholds and additional treatment episode cost ($17,203.74) were used. One-way and probabilistic sensitivity analyses were conducted. Two recovery community organizations (RCOs) were involved in model refinement and calculator development in 2022.<i>Results:</i> Post-treatment PRSS were cost-effective to all thresholds and perspectives: $5,898.60 per QALY and $10,562.08 per person in recovery from the health system perspective, and $3,421.58 per QALY and $6,126.72 per person in recovery from the societal perspective, and post-treatment PRSS remained cost-effective across a variety of conditions in the sensitivity analyses. A cost-effectiveness calculator was developed from the analysis and is available at https://go.uth.edu/cea.<i>Conclusions:</i> In light of finding PRSS cost-effective, the expansion of PRSS across the US should continue, and may be aided by using the cost-effectiveness calculator to estimate tailored results for a specific program.</p>","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"180-190"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peer recovery support services: an under-explored policy tool in the substance use crisis.","authors":"Carol Xu, Zachary Sturman","doi":"10.1080/00952990.2025.2469087","DOIUrl":"10.1080/00952990.2025.2469087","url":null,"abstract":"","PeriodicalId":48957,"journal":{"name":"American Journal of Drug and Alcohol Abuse","volume":" ","pages":"149-151"},"PeriodicalIF":2.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}