Clinical Interventions in Aging最新文献

{"title":"Preoperative Prognostic Nutritional Index Is a Predictive Factor for Postoperative Delirium in Elderly Patients with Femoral Neck Fracture.","authors":"Yuansheng Xu, Yongjun Luo","doi":"10.2147/CIA.S518366","DOIUrl":"10.2147/CIA.S518366","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential risk factors of postoperative delirium (POD) in elderly patients (≥65 years old) undergoing femoral neck fracture (FNF) surgery, and explore whether preoperative prognostic nutritional index (PNI) could predict the occurrence of POD.</p><p><strong>Methods: </strong>A total of 260 cases with FNF were included in this study at The Affiliated Jinling Hospital of Nanjing University from May 2018 and May 2024. The baseline characteristics were recorded. The receiver operating characteristic (ROC) curve analysis was developed to evaluate the diagnostic ability of preoperative PNI for POD. LASSO regression and multivariate logistic regression analyses were used to identify the risk factors for POD.</p><p><strong>Results: </strong>Eighty-one of the 260 cases with FNF suffered POD with an incidence of 31.2%. Patients with POD showed lower Mini-Mental State Examination (MMSE) score (<i>P</i>=0.011), lymphocyte count (<i>P</i>=0.002), albumin level (<i>P</i>=0.011), and PNI level (<i>P</i><0.001) than those in non-POD group. ROC curve analysis indicated that PNI was a good predictor for POD with an area under the curve (AUC) value of 0.708 (95% CI: 0.648-0.762, <i>P</i><0.001); the sensitivity and specificity were 79.01 and 60.89, respectively. LASSO regression analysis identified eleven key variables including gender, age, body mass index, diabetes mellitus, surgery duration, anesthesia duration, fracture position, neutrophil, lymphocyte, PNI, and MMSE score. Multivariate logistic regression analysis showed that MMSE score < 27, BMI > 23.9 kg/m², and PNI < 45.45 were independent risk factors of POD.</p><p><strong>Conclusion: </strong>In conclusion, preoperative PNI is a significant predictor for POD in elderly patients after FNF surgery.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"941-950"},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normobaric Hyperoxia Therapy in Treating Stroke.","authors":"Yanli Duan, Xiangyu Li, Song Han, Jingwei Guan, Zhiying Chen, Weili Li, Ran Meng, Jiayue Ding","doi":"10.2147/CIA.S521584","DOIUrl":"10.2147/CIA.S521584","url":null,"abstract":"<p><p>Normobaric hyperoxia (NBO) is a standard oxygenation intervention for various conditions/diseases including stroke. The present review summarizes the current literature addressing the neuroprotective mechanisms of NBO in acute ischemic stroke (AIS), intracranial hemorrhage, and chronic cerebral ischemia, as well as its combination with other therapies to identify a more appropriate and effective NBO treatment method and to benefit more patients in clinical settings. The primary mechanism of action of NBO is the elevation of the interstitial partial pressure of oxygen in arterial blood (<i>Pa</i>O₂) in brain tissue. NBO preconditioning yields moderate production of free radicals before AIS, which can increase antioxidant enzyme production, alter mitochondrial membrane lipids, increase tumor necrosis factor-alpha (TNF-α) converting enzyme levels, stimulate the hypoxia-inducible factor signaling pathway, upregulate glutamate transporters, Na⁺-Ca⁺ exchanger, and the metabotropic glutamate receptor after AIS, thus conferring neuroprotection to brain tissue. NBO postconditioning benefits AIS by protecting the penumbra and extending the recanalization time window, indicating that reperfusion is critical for the beneficial effects of NBO. Some previous clinical trials have obtained negative results because they enrolled non-reperfused cohorts. Given penumbra protection, NBO can enhance the efficacy of recanalization therapy, including thrombolysis and endovascular treatment. Clinical studies have indicated that NBO benefits only patients with reperfusion, which is consistent with animal-based research. NBO combined with medications, such as ethanol, minocycline, and edaravone, can more effectively treat AIS than NBO alone. Moreover, NBO demonstrates promise for the treatment of intracranial hemorrhage and chronic cerebral ischemia. NBO is a safe and effective therapy for stroke; however, eligible populations should be restricted to those with penumbra or ischemic and hypoxic brain tissues.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"969-981"},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More Than Just Exercise: Older Adults' Experience of the Peer-Led Group-Based FallFitness Program.","authors":"Marina Arkkukangas, Karin Strömqvist Bååthe, Michail Tonkonogi, Maria Liljeroos","doi":"10.2147/CIA.S527142","DOIUrl":"10.2147/CIA.S527142","url":null,"abstract":"<p><strong>Background: </strong>Falls threaten the health and well-being of older adults. While studies have presented effective fall prevention exercises, determining how to deliver these interventions in a way that ensures engagement and long-term sustainability is challenging. Additionally, understanding how older adults perceive and are motivated to participate in such programs is critical for broad public health promotion. This study aimed to explore older adults' experiences and perceptions regarding participation in a newly developed 8-week peer-led group-based exercise program, FallFitness.</p><p><strong>Methods: </strong>Participants were recruited from a randomized controlled trial (RCT) exploring a newly developed 8-week peer-led group-based exercise program. A total of 2 focus groups were conducted post intervention, comprising ten participants (8 women and 2 men) from the exercise arm of the RCT. Inductive and conventional qualitative content analysis was performed.</p><p><strong>Results: </strong>From the interviews, 5 main categories and 6 subcategories capturing the study aim are presented. Main categories included: a) social interaction and community, more than just exercise, b) increased motivational drive and self-efficacy, c) group exercise as fun, safe, and inclusive activity, d) enhanced collaboration between healthcare providers and retirement organizations for fall prevention, and e) professional peer-led trainers.</p><p><strong>Conclusion: </strong>Peer-led, well-designed group-based exercise programs can holistically support physical, emotional, and social well-being. Programs that include enjoyable, multicomponent elements, both physically and mentally stimulating, can enhance participants' motivation and adherence. Additionally, the group setting is thought to promote meaningful social interaction, which is widely recognized as important for overall well-being. From a public health perspective, collaborative models for fall prevention involving older adults as a \"golden resource\" should be established.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT06265480 (2024-02-08).</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"931-939"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, Reliability, and Validity of Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.","authors":"Nannan Jiang, Azidah Abdul Kadir, Hui Xie, Li Wang, Hua Yu, Intan Idiana Hassan","doi":"10.2147/CIA.S512322","DOIUrl":"10.2147/CIA.S512322","url":null,"abstract":"<p><strong>Purpose: </strong>With the accelerating ageing population, frailty has emerged as a critical concern among older cancer patients. The purpose of the study was to develop a valid and reliable Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.</p><p><strong>Patients and methods: </strong>The FOAC was developed in 4 phases. Phase 1: Conceptualization and Item Generation:32 items were formulated from the literature. Phase 2: Content validation of the FOAC by modified Delphi method. Phase 3: Face validity index (FVI) was calculated by recording the views of two groups, including older adults with cancer and those with professional roles. Phase 4:Using CGA-determined frailty as the dependent variable, receiver operating characteristic (ROC) curve analysis was conducted using FOAC, FP, and aCGA frailty screening scales as independent variables and their area under the curve (AUC), sensitivity, specificity, cut-off value, predicted value, and accuracy were determined. Internal consistency reliability measurement was assessed with Cronbach's alpha.</p><p><strong>Results: </strong>The FOAC has 30 items. Physiological dimension (11 items). Psychological & cognitive dimension (12 items). Social support (7 items). the results of this study demonstrated that the overall Cronbach's alpha coefficient of the scale was 0.869.</p><p><strong>Conclusion: </strong>The FOAC is a valid and reliable frailty screening tool that significantly addresses the problems of existing frailty assessment tools, such as single dimension, low sensitivity, complex scoring, and insufficient clinical applicability. It contributes to guiding healthcare professionals in providing more accurate diagnosis, treatment, and cancer management for older adults.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"951-967"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose Factor ANGPTL4: Its Role in Aging Mechanisms and Associated Diseases.","authors":"Xiaojun Wang, Hung-Chen Chang, Xuchao Gu, Yuxin Zhang, Zhijun Bao","doi":"10.2147/CIA.S522049","DOIUrl":"10.2147/CIA.S522049","url":null,"abstract":"<p><p>The angiopoietin-like protein 4 (ANGPTL4), also known as fasting-induced adipose factor, is a secreted glycoprotein that belongs to the ANGPTL protein family. Due to its expression in various cell types and tissues and its interactions with other proteins, ANGPTL4 plays diverse roles within its family, exhibiting a wider range of molecular functions. For instance, ANGPTL4 is intricately involved in modulating central energy metabolism and enhancing exercise endurance, while also acting as a pivotal mediator in the interaction between gut microbiota and host lipid metabolism. Moreover, the expression of ANGPTL4 is directly controlled by aging-related signaling pathways. Its excessive activation accelerates the aging process by triggering mechanisms like heightened oxidative stress, epithelial-mesenchymal transition (EMT) and fibrosis, abnormal lipid accumulation, and cellular arrest, thereby advancing the development of age-related diseases. Given the pivotal roles of ANGPTL4 and its associated molecules in organ fibrosis and cancer advancement, targeting ANGPTL4 emerges as a promising therapeutic approach. However, the intricate and sometimes conflicting functions of the two cleavage fragments of ANGPTL4, namely N-terminal fragment (nANGPTL4) and C-terminal fragment (cANGPTL4), in different chronic diseases-exerting inhibitory or stimulatory effects depending on the disease stage-have posed challenges to the progress of ANGPTL4 antibody therapy. This review provides an overview of the biological mechanisms of ANGPTL4, its dual impact on fibrosis and tumorigenesis, and highlights its recent advancements as a potential biomarker in age-related diseases and inflammation-related conditions. ANGPTL4 is a high-potential but complex target, requiring mechanism-driven strategies for safe clinical translation.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"911-929"},"PeriodicalIF":3.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144555485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Frailty and Albuminuria in the Community-Dwelling Geriatric Population.","authors":"Chih-Hsueh Lin, Che-Yi Chou, Tsai-Chung Li, Chiu-Shong Liu, Wen-Yuan Lin, Chia-Ing Li, Chuan-Wei Yang, Cheng-Chieh Lin","doi":"10.2147/CIA.S518738","DOIUrl":"10.2147/CIA.S518738","url":null,"abstract":"<p><strong>Aim: </strong>Elderly with frailty are more at risk of cardiovascular disease and all-cause mortality than the general population. Albuminuria is a risk factor for atherosclerosis, a major cause of frailty. We investigated the association between frailty and albuminuria in community-dwelling elderly.</p><p><strong>Methods: </strong>This was a cross-sectional study for analyzing 1347 participants aged at least 65 years in the north district of Taichung, Taiwan. We defined the frailty phenotype as at least three characteristics: weight loss, exhaustion, weakness, slow walking speed, and decreased physical activity. We collected random urine and measured all participants' albumin/creatinine ratio (ACR). We analyzed the association between frailty and ACR using logistic regression with adjustments for confoundings.</p><p><strong>Results: </strong>The average age of 1347 participants was 76 ± 7 years, and 649 (48.2%) were male. Two hundred and forty-two (18.7) participants were robust, 853 (63.3%) participants were pre-frail, and 242 (18%) were frail. One thousand sixty-four (79%) participants had an ACR < 30 mg/g; the highest ACR was 2825 mg/g. The odds ratio of ACR was 1.12 (95% confidence interval 1.05-1.25, p = 0.001) with adjustments for age, body mass index, estimated glomerular filtration rate, diabetes, liver function, and cholesterol.</p><p><strong>Conclusion: </strong>Frailty is associated with urinary albuminuria in community-dwelling elderly, and this association is independent of traditional and non-traditional cardiovascular risk factors.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"903-909"},"PeriodicalIF":3.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase Angle Predicts Malnutrition Risk and 6-month Mortality in Older Patients with Multimorbidity: A Retrospective Study.","authors":"Tingting Liu, Yao Wang, Yuan Wang, Dong Xia","doi":"10.2147/CIA.S518795","DOIUrl":"10.2147/CIA.S518795","url":null,"abstract":"<p><strong>Background: </strong>This study examined the utility of the phase angle (PhA) in predicting malnutrition risk and 6-month mortality in older patients with multimorbidity.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 104 hospitalized older adults with multiple chronic conditions. Data on clinical parameters, body composition, and nutritional status (via Nutritional Risk Screening 2002) were analyzed. Pearson's correlation analysis and receiver operating characteristic analysis were used to identify the optimal PhA cutoff for malnutrition risk. Mortality and malnutrition were compared between the low and high PhA groups.</p><p><strong>Results: </strong>PhA was significantly correlated with age, BMI, hemoglobin, albumin, triglycerides, and the extracellular water/total body water ratio (all <i>P</i> < 0.05). The optimal PhA cutoff was 3.15°, which had 62% sensitivity and 79% specificity for malnutrition prediction. Patients in the low PhA group had significantly higher rates of malnutrition (80.85% vs 40.35%, <i>P</i> < 0.05) and mortality (29.79% vs 3.5%, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>PhA is a clinically valuable tool for assessing malnutrition risk and predicting mortality in older patients with multimorbidity. It enables early identification and intervention, improving patient outcomes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"895-902"},"PeriodicalIF":3.5,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144545716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in the Optimization of Surgical Timing in Elderly Patients with Hip Fractures: A Narrative Review and Future Perspectives.","authors":"Xin Xu, Hui Yu, Junxiang Wang, Junfei Guo","doi":"10.2147/CIA.S526209","DOIUrl":"10.2147/CIA.S526209","url":null,"abstract":"<p><p>The optimal timing for hip fracture surgery in elderly patients remains a topic of intense debate and complexity, with many factors influencing the decision-making process. This review examines the current evidence, exploring the advantages and challenges of early versus delayed intervention. It considers medical stability, preoperative medical stabilization, and patient comorbidities, and logistical challenges such as operating room availability and specialized physician access. While multiple studies have examined early versus delayed surgery, a universally agreed definition of \"unacceptable delay\" is absent. Some evidence indicates that postponing surgery beyond 24 hours may not significantly impact mortality and complication rates, especially in individuals with complex medical conditions. Conversely, early intervention within 48 hours is often recommended for stable patients. Several contributing factors, such as preoperative medical stabilization, hospital resources, and organizational structures, further complicate the issue. This review highlights the need for a nuanced, individualized, and patient-centered approach, taking into account the unique needs of each patient and the specific circumstances of the healthcare setting. It also emphasizes the importance of further research to provide a more comprehensive understanding of what constitutes an optimal delay, rather than adhering to rigid time frames. By offering a multifaceted examination of this critical subject, the review contributes valuable insights that may guide future clinical practice and policy in orthopedic care.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"881-894"},"PeriodicalIF":3.5,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Preoperative Deep Vein Thrombosis Using d-Dimer-to-Albumin Ratio Combined with Neutrophil-to-Lymphocyte Ratio in Older Patients with Hip Fracture.","authors":"Wenbin Lu, Fan Jia, Miaomiao Rao, Wubin Chen, Yi Liu, Jinjun Bian","doi":"10.2147/CIA.S523443","DOIUrl":"10.2147/CIA.S523443","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the potential value of the d-dimer to albumin ratio (DAR) combined with the neutrophil-to-lymphocyte ratio (NLR) for predicting preoperative lower extremity deep vein thrombosis (DVT) in older patients with hip fracture.</p><p><strong>Methods: </strong>Demographic characteristics, comorbidities, medication history, and preoperative laboratory test results were collected from older patients with hip fracture between 2018 and 2023. Binary logistic regression analysis was used to assess the association between the DAR, NLR, and DVT. Receiver operating characteristic (ROC) curve analysis was performed to calculate the potential value of DAR combined with NLR in predicting preoperative DVT.</p><p><strong>Results: </strong>A total of 1177 patients were included, of whom 23 (2%) developed lower extremity DVT before surgery. Multivariate logistic regression analysis indicated that age (OR = 1.08, 95% CI = 1.01~1.15, <i>P</i> = 0.015), DAR (OR = 1.53, 95% CI = 1.21~1.92, <i>P</i> < 0.001), and NLR (OR = 1.24, 95% CI = 1.10~1.39, <i>P</i> < 0.001) were independently associated with preoperative DVT in older patients with hip fractures. Furthermore, the ROC curve analysis indicated that DAR combined with NLR has a significant predictive value for DVT, with an area under the curve of 78.72% (95% CI = 68.24-89.20%).</p><p><strong>Conclusion: </strong>The preoperative DAR and NLR were independently associated with preoperative DVT in older patients with hip fractures. DAR combined with NLR can be considered as a predictive indicator of DVT.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"873-879"},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falls, Sleep Disorders and Cognitive Frailty in Hospitalized Older Adults with Hypertension:A Cross-Sectional Study.","authors":"Xiaoyan Li, Huizhen Li, Shibao Gan, Youran Zhang, Dianhe Yin, Baihui Zhu, Shiyi Wang, Yuru Liu","doi":"10.2147/CIA.S510228","DOIUrl":"10.2147/CIA.S510228","url":null,"abstract":"<p><strong>Purpose: </strong>Falls and fall-related injuries are highly prevalent among older adults. Falls negatively impact functional independence and quality of life, and are associated with increased morbidity, mortality, and healthcare costs. Sleep disorders in the older adults are a common phenomenon, with sleep quality gradually deteriorating as age increases. Cognitive frailty(CF) refers to the presence of both physical frailty(PF) and mild cognitive impairment(MCI) without simultaneous diagnosis of Alzheimer's disease(AD) or other dementia. Epidemiological studies have confirmed the association between falls and sleep disorders, as well as CF. However, no studies have yet investigated the relationship between falls, sleep disorders and CF in hospitalized older adults with hypertension. Our study is to explore the relationship between falls and both sleep disorders and CF in hospitalized older adults with hypertension, providing a basis for fall prevention.</p><p><strong>Patients and methods: </strong>Demographic characteristics were collected from hypertensive patients aged 65 and above who were hospitalized in the Department of Geriatrics at Huaihe Hospital of Henan University, from July 2022 to June 2024. These patients were assessed for history of falls, sleep quality, CF, depression and nutritional status. Logistic regression analysis was used to examine the correlation between falls and both sleep disorders and CF.</p><p><strong>Results: </strong>A total of 266 older adults with hypertension were surveyed in this study, of whom 108 reported having fallen once or more in the past year. Both sleep disorders and CF were significantly associated with an increased risk of falls (sleep disorders: OR=2.625, 95% CI 1.214-5.678, P=0.014; CF: OR=5.920, 95% CI 2.632-13.314, P<0.001). Other significant risk factors included: Age (OR=1.119, 95% CI 1.055-1.188, P<0.001), Comorbidities (OR=2.855, 95% CI 1.353-6.024, P=0.006), Polypharmacy (OR=4.126, 95% CI 1.937-8.793, P<0.001), Compared to hospitalized older adults with hypertension with good nutritional status, those with malnutrition had a 4.698-fold higher risk of falls (95% CI 1.724-12.800, P=0.002).</p><p><strong>Conclusion: </strong>The incidence of falls was higher among hospitalized older adults with hypertension. Both sleep disorders and CF were strongly associated with falls in this patient population.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"859-872"},"PeriodicalIF":3.5,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}