Clinical Interventions in Aging最新文献

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Sex-Specific Associations Between Oral Function Impairment and Clinical Outcomes in Hospitalized Older Adults: A Retrospective Observational Study. 住院老年人口腔功能损害与临床结果的性别特异性关联:一项回顾性观察研究。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-16 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S524802
Yen-Yang Lee, Shuo-Chun Weng, Yu-Shan Lee, Yin-Yi Chou, Fu-Hsuan Kuo, Shu-Hui Yang, Ya-Hui Yeh, Wei-Min Chu, Chiann-Yi Hsu, Shih-Yi Lin, Cheng-Fu Lin
{"title":"Sex-Specific Associations Between Oral Function Impairment and Clinical Outcomes in Hospitalized Older Adults: A Retrospective Observational Study.","authors":"Yen-Yang Lee, Shuo-Chun Weng, Yu-Shan Lee, Yin-Yi Chou, Fu-Hsuan Kuo, Shu-Hui Yang, Ya-Hui Yeh, Wei-Min Chu, Chiann-Yi Hsu, Shih-Yi Lin, Cheng-Fu Lin","doi":"10.2147/CIA.S524802","DOIUrl":"10.2147/CIA.S524802","url":null,"abstract":"<p><strong>Purpose: </strong>Oral functional impairment is a critical factor influencing clinical outcomes in hospitalized older adults. Notably, sex disparities in oral health on clinical outcomes remain an often underappreciated aspect.This study aims to investigate the association between oral function, assessed using the bedside oral examination (BOE), and in-hospital mortality, with an emphasis on sex-specific differences.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted involving 1,141 patients aged 65 years and older who were admitted to a medical center in Taiwan between 2018 and 2023. The BOE was a standardized clinical tool that evaluated eight domains of oral health, including swallowing, lips, tongue, saliva, mucous membranes, gingiva, teeth or dentures, and oral odor. Patients were classified into normal, moderate, or severe oral impairment groups. Cox proportional hazards models and Kaplan-Meier survival analysis were used to examine mortality risk, with results stratified by sex.</p><p><strong>Results: </strong>Overall, greater oral functional impairment was associated with higher in-hospital mortality and poorer physical, nutritional, and psychological status. In the sex-stratified analysis, severe oral impairment remained an independent predictor of mortality in male patients (hazard ratio 1.77, 95% confidence interval 1.05 to 2.99, p = 0.032), but not in female patients. Survival differences were statistically significant among men based on oral function levels, as shown by Kaplan-Meier curves (log-rank p = 0.014), while no significant difference was found among women (log-rank p = 0.376).</p><p><strong>Conclusion: </strong>Severe oral functional impairment significantly predicts in-hospital mortality among older men, but not women. These findings underscore the importance of sex-specific approaches to risk assessment and intervention. Incorporating oral health screening into routine geriatric care, especially for men, may enhance early identification of high-risk patients and inform targeted strategies to improve clinical outcomes. Further research is warranted to understand the mechanisms underlying these sex differences.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1049-1061"},"PeriodicalIF":3.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Glycated Hemoglobin and Diabetic Retinopathy in Individuals with Diabetes: A Focus on the Modifying Effect of Ambulatory Blood Pressure. 糖尿病患者糖化血红蛋白与糖尿病视网膜病变的关系:动态血压调节作用的研究
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S514622
Shenglan Yang, Hui Liu, Yao Liang, Lijing Wu, Qidong Zheng, Jing Wu
{"title":"Association Between Glycated Hemoglobin and Diabetic Retinopathy in Individuals with Diabetes: A Focus on the Modifying Effect of Ambulatory Blood Pressure.","authors":"Shenglan Yang, Hui Liu, Yao Liang, Lijing Wu, Qidong Zheng, Jing Wu","doi":"10.2147/CIA.S514622","DOIUrl":"10.2147/CIA.S514622","url":null,"abstract":"<p><strong>Background: </strong>Suboptimal glycemic control in individuals with diabetes is one of the major contributors to the development of diabetic retinopathy (DR). However, the role of ambulatory blood pressure (ABP) in this association remains unclear. The purpose of this research was to assess the associations among ABP, glycosylated hemoglobin (HbA1c), and DR in a diabetic population, with an emphasis on individuals exhibiting suboptimal glycemic and BP control.</p><p><strong>Methods: </strong>This study included 498 diabetic patients with comprehensive ABP data. The assessment of diabetes is based on the criteria of the American Diabetes Association (ADA). We adopted Least Absolute Shrinkage and Selection Operator (Lasso) regression to identify key variables and used logistic regression to investigate associations, followed by subgroup analyses.</p><p><strong>Results: </strong>After adjustment for covariance variables, HbA1c showed a strong correlation with DR (OR: 1.228, 95% CI: 1.010-1.368). Among participants with low ABP, the prevalence of DR rises significantly with higher HbA1c levels (OR: 1.217,95% CI:1.057-1.402), whereas in those with elevated ABP (OR:1.366,95% CI:1.122-1.662), this relationship was markedly stronger, particularly in the context of Awake systolic blood pressure (SBP). Comparable findings were noted in both categorical models, as well as in subgroup analyses. However, heterogeneity was observed in subgroup analyses stratified by age.</p><p><strong>Conclusion: </strong>ABP may modify the relationship between HbA1c and DR; specifically, suboptimal glycemic management in patients at elevated ABP levels exacerbates the risk of DR. Therefore, it is imperative for diabetic patients to prioritize both BP regulation and glycemic management in their comprehensive disease management strategy.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1029-1038"},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Expectations Regarding Aging and Related Influencing Factors in Older People with Type 2 Diabetes Mellitus: A Cross-Sectional Study. 探讨老年2型糖尿病患者对衰老的预期及相关影响因素:一项横断面研究
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S530212
Ting Yao, Qiuxia Jiang, Feng Zhang, Hong Cao, Dan Li, Jiai Yan, Yingyu Wang, Ju Yang, Ruijuan Zhuang, Jing Sun
{"title":"Exploring Expectations Regarding Aging and Related Influencing Factors in Older People with Type 2 Diabetes Mellitus: A Cross-Sectional Study.","authors":"Ting Yao, Qiuxia Jiang, Feng Zhang, Hong Cao, Dan Li, Jiai Yan, Yingyu Wang, Ju Yang, Ruijuan Zhuang, Jing Sun","doi":"10.2147/CIA.S530212","DOIUrl":"10.2147/CIA.S530212","url":null,"abstract":"<p><strong>Purpose: </strong>Improving the health behaviors of older type 2 diabetes mellitus (T2DM) patients is crucial for promoting healthy aging worldwide. Given the significant role of expectations regarding aging (ERA) in fostering healthy behaviors and improving disease outcomes, understanding its status and influencing factors in this population is essential.</p><p><strong>Patients and methods: </strong>The cross-sectional study was conducted from December 2023 to February 2024 at a tertiary hospital in China, where 289 elderly T2DM patients were surveyed. Self-reported questionnaires were used to assess sociodemographic and clinical data, ERA, depression, social support, diabetes self-efficacy. Data were analyzed using SPSS 26.0 software, employing Pearson correlation analysis, univariate analysis, and multiple stepwise linear regression.</p><p><strong>Results: </strong>The ERA score in older T2DM patients was 39.72 ± 9.53, which was at a medium-low level. The level of ERA is negatively correlated with depression (r = -0.549, <i>p</i> < 0.01) and positively correlated with social support (r = 0.625, <i>p</i> < 0.01) and diabetes self-efficacy (r = 0.514, <i>p</i> < 0.01). Age, family monthly income, type of daily medication, number of sources for diabetes-related knowledge, as well as depression, social support, and diabetes self-efficacy are factors that influence ERA and can explain 59.2% of the total variance.</p><p><strong>Conclusion: </strong>Efforts should be made to promote ERA in older patients with T2DM. Healthcare providers should develop intervention strategies based on identifying the factors that influence the ERA in elderly T2DM patients to improve their health outcomes and enhance their health management awareness, thereby improving the quality of their later years.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1039-1048"},"PeriodicalIF":3.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of a Diagnostic Nomogram Model for Predicting Cognitive Frailty in Acute Coronary Syndrome. 急性冠脉综合征认知衰弱诊断图模型的建立与验证。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-14 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S527085
Shan Wang, Ying Sun, Wen Tang, Shangxin Lu, Feng Feng, Xiaopei Hou, Lihong Ma, Runzhi Li, Jieqiong Hu, Bing Liu, Yunli Xing
{"title":"Development and Validation of a Diagnostic Nomogram Model for Predicting Cognitive Frailty in Acute Coronary Syndrome.","authors":"Shan Wang, Ying Sun, Wen Tang, Shangxin Lu, Feng Feng, Xiaopei Hou, Lihong Ma, Runzhi Li, Jieqiong Hu, Bing Liu, Yunli Xing","doi":"10.2147/CIA.S527085","DOIUrl":"10.2147/CIA.S527085","url":null,"abstract":"<p><strong>Background: </strong>Cognitive frailty (CF) is strongly associated with major adverse cardiovascular events, yet its assessment requires specialized equipment, limiting clinical practicality. This study aimed to develop and validate a nomogram model for predicting CF in patients with acute coronary syndrome (ACS) to enhance early identification and intervention.</p><p><strong>Methods: </strong>Patients with ACS (N=547) were enrolled and randomly split into a training set (70%) and a testing set (30%). The training set was used to construct the nomogram, while the testing set was used for validation. Model performance was evaluated using the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) to assess discrimination, accuracy, and clinical utility, respectively.</p><p><strong>Results: </strong>The nomogram included six predictors: education level, age, systolic blood pressure (SBP), Charlson Comorbidity Index (CCI), Short Physical Performance Battery (SPPB), and nutritional status. The model demonstrated strong discriminatory power, with an area under the ROC curve of 0.854 (95% CI: 0.741-0.861) in the training cohort and 0.733 (95% CI: 0.500-0.898) in the testing cohort. Calibration analysis confirmed high accuracy, and DCA indicated significant net benefits across both cohorts, supporting its clinical applicability.</p><p><strong>Conclusion: </strong>The nomogram effectively predicts CF in ACS patients by considering education, age, SBP, CCI, SPPB, and nutritional status, serving as a visual aid for healthcare providers to facilitate the early identification and intervention of CF. Future research is needed to validate the nomogram's efficacy in diverse populations and explore standardized assessment methods that enhance its clinical applicability in mitigating CF in ACS patients.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1015-1027"},"PeriodicalIF":3.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Chronic Pain, Coping Strategies, and Sleep Quality in Rural Chinese Older Adults: A Cross-Sectional Study. 中国农村老年人慢性疼痛、应对策略和睡眠质量的关系:一项横断面研究。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-12 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S533869
Xin Tao, Cheng Cheng, Jie Bai
{"title":"Association Between Chronic Pain, Coping Strategies, and Sleep Quality in Rural Chinese Older Adults: A Cross-Sectional Study.","authors":"Xin Tao, Cheng Cheng, Jie Bai","doi":"10.2147/CIA.S533869","DOIUrl":"10.2147/CIA.S533869","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the current status of sleep quality and explore the associations between chronic pain, sleep quality, and coping strategies in older adults living in rural areas of China, a topic of growing interest and importance in gerontology and public health.</p><p><strong>Patients and methods: </strong>This was an observational, cross-sectional study with a convenience sample of Chinese older adults from a rural community in Northern Anhui, China, conducted from September to December 2023. A self-reported questionnaire was used to collect data on socio-demographic items, chronic pain (visual analogue scale, VAS), coping strategies (Coping Strategies Questionnaire-Revised, CSQ-R), and sleep quality (Athens Insomnia Scale, AIS). Descriptive statistics, Pearson correlation, Stepwise multiple linear regression, and mediation analysis were used to analyze the data.</p><p><strong>Results: </strong>A total of 158 participants (48.7% female) were included in the study. Most participants (73.4%, n = 116) reported poor sleep quality. The regression model revealed significant associations between sleep quality and chronic pain (Beta = 0.599, t = 9.99, p < 0.001) and praying as a way of coping (Beta = 0.165, t = 2.72, p = 0.007). The model explained 46.5% of the variance in sleep quality (p < 0.01). Mediation analysis indicated that chronic pain had an indirect effect on sleep quality via praying, even after controlling for covariates (B = 0.137, 95% CI = 0.0614, 0.2227).</p><p><strong>Conclusion: </strong>This study displayed a significant association between chronic pain, coping strategies, and sleep quality in Chinese older adults living in rural areas. Chronic pain directly affects sleep quality, while praying as a coping strategy may mitigate this effect. Nurses should prioritize pain management and promote adaptive coping strategies to improve sleep quality.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"1005-1014"},"PeriodicalIF":3.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient-Centered Care in Family Medicine: Strategies for Continuity and Comprehensive Care for Older Adults - A Mixed-Methods Study. 家庭医学中以患者为中心的护理:老年人连续性和综合护理的策略-一项混合方法研究。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-04 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S513624
Abdulaziz M Alodhialah, Ashwaq A Almutairi, Mohammed Almutairi
{"title":"Patient-Centered Care in Family Medicine: Strategies for Continuity and Comprehensive Care for Older Adults - A Mixed-Methods Study.","authors":"Abdulaziz M Alodhialah, Ashwaq A Almutairi, Mohammed Almutairi","doi":"10.2147/CIA.S513624","DOIUrl":"10.2147/CIA.S513624","url":null,"abstract":"<p><strong>Introduction: </strong>Patient-centered care (PCC) is a crucial approach in family medicine, particularly for older adults with complex health needs. This study evaluates the implementation of PCC strategies and their impact on health outcomes for older adults in family medicine settings.</p><p><strong>Methods: </strong>A convergent parallel mixed-methods study was conducted, involving 47 healthcare providers and 126 older adult patients in Riyadh, Saudi Arabia. Quantitative data were collected using structured surveys, while qualitative data were obtained through semi-structured interviews. Statistical analyses included chi-square tests, ANOVA, and effect size calculations to assess the impact of PCC strategies.</p><p><strong>Results: </strong>Healthcare providers identified continuity of care programs (48.9%) and patient education (44.7%) as the most effective PCC strategies. Key challenges included time constraints (74.5%) and lack of resources (59.6%). Patients in the high PCC implementation group demonstrated significantly better health outcomes, including lower hospital readmission rates (15.9% vs 36.5%, p=0.002), improved chronic disease management (87.3% vs 66.7%, p=0.014), higher adherence to care plans (82.5% vs 60.3%, p=0.008), and increased patient satisfaction scores (mean 4.6 vs 3.9, p=0.001). Qualitative findings highlighted key themes, including communication challenges, patient empowerment, and the role of multidisciplinary teams.</p><p><strong>Discussion: </strong>PCC strategies significantly enhance health outcomes and patient satisfaction among older adults in family medicine. However, implementation barriers such as time constraints, resource limitations, and coordination challenges must be addressed. The study underscores the need for systemic healthcare reforms to improve PCC delivery.</p><p><strong>Conclusion: </strong>This study highlights the benefits of PCC in improving patient outcomes and satisfaction while identifying barriers that must be addressed for effective implementation. Greater investment in PCC initiatives, improved healthcare coordination, and professional training are essential to enhancing care quality for older adults.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"985-1003"},"PeriodicalIF":3.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: The Potential Value of Prehabilitation for Preventing Delirium in Elective Surgery for Aneurysms of the Abdominal Aorta [Corrigendum]. 在腹主动脉动脉瘤择期手术中预防谵妄的潜在价值[勘误]。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S544931
{"title":"Erratum: The Potential Value of Prehabilitation for Preventing Delirium in Elective Surgery for Aneurysms of the Abdominal Aorta [Corrigendum].","authors":"","doi":"10.2147/CIA.S544931","DOIUrl":"https://doi.org/10.2147/CIA.S544931","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/CIA.S420861.].</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"983-984"},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Prognostic Nutritional Index Is a Predictive Factor for Postoperative Delirium in Elderly Patients with Femoral Neck Fracture. 术前预后营养指数是老年股骨颈骨折患者术后谵妄的预测因素。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S518366
Yuansheng Xu, Yongjun Luo
{"title":"Preoperative Prognostic Nutritional Index Is a Predictive Factor for Postoperative Delirium in Elderly Patients with Femoral Neck Fracture.","authors":"Yuansheng Xu, Yongjun Luo","doi":"10.2147/CIA.S518366","DOIUrl":"10.2147/CIA.S518366","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the potential risk factors of postoperative delirium (POD) in elderly patients (≥65 years old) undergoing femoral neck fracture (FNF) surgery, and explore whether preoperative prognostic nutritional index (PNI) could predict the occurrence of POD.</p><p><strong>Methods: </strong>A total of 260 cases with FNF were included in this study at The Affiliated Jinling Hospital of Nanjing University from May 2018 and May 2024. The baseline characteristics were recorded. The receiver operating characteristic (ROC) curve analysis was developed to evaluate the diagnostic ability of preoperative PNI for POD. LASSO regression and multivariate logistic regression analyses were used to identify the risk factors for POD.</p><p><strong>Results: </strong>Eighty-one of the 260 cases with FNF suffered POD with an incidence of 31.2%. Patients with POD showed lower Mini-Mental State Examination (MMSE) score (<i>P</i>=0.011), lymphocyte count (<i>P</i>=0.002), albumin level (<i>P</i>=0.011), and PNI level (<i>P</i><0.001) than those in non-POD group. ROC curve analysis indicated that PNI was a good predictor for POD with an area under the curve (AUC) value of 0.708 (95% CI: 0.648-0.762, <i>P</i><0.001); the sensitivity and specificity were 79.01 and 60.89, respectively. LASSO regression analysis identified eleven key variables including gender, age, body mass index, diabetes mellitus, surgery duration, anesthesia duration, fracture position, neutrophil, lymphocyte, PNI, and MMSE score. Multivariate logistic regression analysis showed that MMSE score < 27, BMI > 23.9 kg/m<sup>2</sup>, and PNI < 45.45 were independent risk factors of POD.</p><p><strong>Conclusion: </strong>In conclusion, preoperative PNI is a significant predictor for POD in elderly patients after FNF surgery.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"941-950"},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normobaric Hyperoxia Therapy in Treating Stroke. 常压高氧治疗脑卒中。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S521584
Yanli Duan, Xiangyu Li, Song Han, Jingwei Guan, Zhiying Chen, Weili Li, Ran Meng, Jiayue Ding
{"title":"Normobaric Hyperoxia Therapy in Treating Stroke.","authors":"Yanli Duan, Xiangyu Li, Song Han, Jingwei Guan, Zhiying Chen, Weili Li, Ran Meng, Jiayue Ding","doi":"10.2147/CIA.S521584","DOIUrl":"10.2147/CIA.S521584","url":null,"abstract":"<p><p>Normobaric hyperoxia (NBO) is a standard oxygenation intervention for various conditions/diseases including stroke. The present review summarizes the current literature addressing the neuroprotective mechanisms of NBO in acute ischemic stroke (AIS), intracranial hemorrhage, and chronic cerebral ischemia, as well as its combination with other therapies to identify a more appropriate and effective NBO treatment method and to benefit more patients in clinical settings. The primary mechanism of action of NBO is the elevation of the interstitial partial pressure of oxygen in arterial blood (<i>Pa</i>O<sub>2</sub>) in brain tissue. NBO preconditioning yields moderate production of free radicals before AIS, which can increase antioxidant enzyme production, alter mitochondrial membrane lipids, increase tumor necrosis factor-alpha (TNF-α) converting enzyme levels, stimulate the hypoxia-inducible factor signaling pathway, upregulate glutamate transporters, Na<sup>+</sup>-Ca<sup>+</sup> exchanger, and the metabotropic glutamate receptor after AIS, thus conferring neuroprotection to brain tissue. NBO postconditioning benefits AIS by protecting the penumbra and extending the recanalization time window, indicating that reperfusion is critical for the beneficial effects of NBO. Some previous clinical trials have obtained negative results because they enrolled non-reperfused cohorts. Given penumbra protection, NBO can enhance the efficacy of recanalization therapy, including thrombolysis and endovascular treatment. Clinical studies have indicated that NBO benefits only patients with reperfusion, which is consistent with animal-based research. NBO combined with medications, such as ethanol, minocycline, and edaravone, can more effectively treat AIS than NBO alone. Moreover, NBO demonstrates promise for the treatment of intracranial hemorrhage and chronic cerebral ischemia. NBO is a safe and effective therapy for stroke; however, eligible populations should be restricted to those with penumbra or ischemic and hypoxic brain tissues.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"20 ","pages":"969-981"},"PeriodicalIF":3.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More Than Just Exercise: Older Adults' Experience of the Peer-Led Group-Based FallFitness Program. 不仅仅是锻炼:老年人在同伴领导的团体跌倒健身项目中的经验。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.2147/CIA.S527142
Marina Arkkukangas, Karin Strömqvist Bååthe, Michail Tonkonogi, Maria Liljeroos
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