Clinical Interventions in Aging最新文献

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The Clinical Frailty Scale is the Significant Predictor for in-Hospital Mortality of Older Patients in the Emergency Department [Letter]. 临床虚弱量表是急诊科老年患者院内死亡率的重要预测指标 [信].
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S490961
Ji Wu, Xiping Shen
{"title":"The Clinical Frailty Scale is the Significant Predictor for in-Hospital Mortality of Older Patients in the Emergency Department [Letter].","authors":"Ji Wu, Xiping Shen","doi":"10.2147/CIA.S490961","DOIUrl":"https://doi.org/10.2147/CIA.S490961","url":null,"abstract":"","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress on Frailty in Elderly People. 老年人体弱研究进展。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-29 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S474547
Xiaoming Liu, Xiaoni Yang
{"title":"Research Progress on Frailty in Elderly People.","authors":"Xiaoming Liu, Xiaoni Yang","doi":"10.2147/CIA.S474547","DOIUrl":"10.2147/CIA.S474547","url":null,"abstract":"<p><p>Global aging is rapidly accelerating, which significantly influences the health systems worldwide. Frailty emerges as the most conspicuous hallmark of aging, imposing novel global health challenges. Characterized by a multifaceted decline across physiological system, frailty diminishes an individual's capacity to maintain equilibrium in the presence of stressors, which leads to adverse outcomes such as falls, delirium, and disability. Several screening tools and interventions have been developed to mitigate the harm caused by frailty to human health, but research on frailty in mainland China commences belatedly with scant studies conducted. Therefore, it is imperative to explore screening methods and treatment modalities tailored to the Chinese context, thereby enhancing the older adults' quality of life and advancing social medicine. This review aims to elucidate the evolution, diagnosis, and management of frailty, alongside the challenges it poses, with the overarching goal of guiding future diagnostic and therapeutic endeavors. Specifically, we summarized the mechanisms of frailty and intervention strategies in elderly people, and meanwhile, we evaluated the advantages and disadvantages of different measurement tools.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Differences in Parameters in Ultrasound Imaging and Biomechanical Properties of the Quadriceps Femoris with Unilateral Knee Osteoarthritis in the Elderly: A Preliminary Observational Study. 老年单侧膝骨关节炎患者股四头肌超声成像参数和生物力学特性的差异:一项初步观察研究
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S442610
Junyi Li, Zugui Wu, Bin Lu, Congcong Li, Shuai Wang, Jiahao Zhang, Xingxing Shen, Ruian Xiang, Jiahao Chen, Tao Jiang, Chuanxi Zhao, Wengang Liu, Xuemeng Xu
{"title":"The Differences in Parameters in Ultrasound Imaging and Biomechanical Properties of the Quadriceps Femoris with Unilateral Knee Osteoarthritis in the Elderly: A Preliminary Observational Study.","authors":"Junyi Li, Zugui Wu, Bin Lu, Congcong Li, Shuai Wang, Jiahao Zhang, Xingxing Shen, Ruian Xiang, Jiahao Chen, Tao Jiang, Chuanxi Zhao, Wengang Liu, Xuemeng Xu","doi":"10.2147/CIA.S442610","DOIUrl":"10.2147/CIA.S442610","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aims to evaluate differences in muscle parameters of the quadriceps muscles in patients with knee osteoarthritis (KOA) in older adults.</p><p><strong>Methods: </strong>The study included 40 patients diagnosed with unilateral knee osteoarthritis in the KOA group (KG) and 40 asymptomatic elderly individuals in the control group (CG). Muscle ultrasonic mean echo intensity and shear modulus, as well as tone and stiffness of the rectus femoris (RF), vastus medialis (VM), and vastus lateralis (VL) were analyzed. Additionally, clinical correlations were performed.</p><p><strong>Results: </strong>In the KG group, there were significant differences in echo intensity, shear modulus, and tone between the affected and unaffected sides for RF (p=0.003, 0.019, 0.014), while VM showed significant differences in shear modulus and tone (p=0.006, 0.002). Additionally, VL exhibited significant differences in echo intensity, shear modulus, and stiffness (p=0.007, 0.006, 0.010). Compared to the CG group, the KG group showed significant differences in echo intensity of the affected side RF (p=0.001). VM exhibited statistically significant differences in echo intensity and shear modulus (p < 0.001, p=0.008), while VL showed statistically significant differences in echo intensity, tone, and stiffness (p < 0.001, p=0.028, p < 0.001). The correlation results showed that patients with unilateral KOA, VM, and VL echo intensity were correlated with K-L grade (r = 0.443, p=0.004; r = 0.469, p=0.002). The tone of VL was correlated with VAS and WOMAC (r = 0.327, p=0.039; r = 0.344, p=0.030).</p><p><strong>Conclusion: </strong>The parameters of the quadriceps femoris muscle exhibit asymmetry between the affected and unaffected sides in patients with unilateral KOA, as well as a difference between the dominant side of healthy older individuals and the affected side of KOA.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Effectiveness of Interventional Therapy versus Exercise Rehabilitation in Stable Angina Patients with Severe Coronary Artery Stenosis. 介入疗法与运动康复对严重冠状动脉狭窄的稳定型心绞痛患者的疗效比较。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-24 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S474811
Yucheng Wu, Jie Qiu, Xiang Sha, Benbingdi Gong, Jian Wang, Wei Yuan, Jie Lin, Lichun Wang, Qingqing Zhang
{"title":"Comparative Effectiveness of Interventional Therapy versus Exercise Rehabilitation in Stable Angina Patients with Severe Coronary Artery Stenosis.","authors":"Yucheng Wu, Jie Qiu, Xiang Sha, Benbingdi Gong, Jian Wang, Wei Yuan, Jie Lin, Lichun Wang, Qingqing Zhang","doi":"10.2147/CIA.S474811","DOIUrl":"10.2147/CIA.S474811","url":null,"abstract":"<p><strong>Background: </strong>Management strategies for stable angina include pharmacotherapy, revascularization, and exercise-based cardiac rehabilitation (CR). The optimal treatment for stable angina patients with severe coronary artery stenosis remains unclear. This study aimed to compare interventional therapy with exercise rehabilitation in this population.</p><p><strong>Methods: </strong>Fifty stable angina patients with severe coronary stenosis who underwent stent implantation were included in the optimal medical therapy (OMT) plus percutaneous coronary intervention (PCI) group, and 50 patients who did not undergo interventional treatment were included in OMT plus CR group receiving exercise rehabilitation guidance for one year. Cardiovascular composite endpoint events, cardiopulmonary fitness, and quality of life scale scores were assessed after one year.</p><p><strong>Results: </strong>No significant difference in incidence of cardiovascular composite endpoint events was observed between OMT plus PCI group with OMT plus CR group (20.0% vs 14.6%) after one year. Cardiopulmonary fitness represented as peak VO<sub>2</sub> (19.2±3.5 vs 17.6±3.2 mL/kg/min), peak load (120±19 vs 108±20 W), and AT (13.5±1.5 vs 12.1±1.3 mL/kg/min) were significantly higher in the rehabilitation group than the intervention group after one year. Both groups showed improvement in their quality of life, but the rehabilitation group improved in more scales.</p><p><strong>Conclusion: </strong>Interventional therapy did not reduce cardiovascular events compared to exercise-based rehabilitation in stable angina patients with severe coronary artery stenosis, but the rehabilitation can improve cardiovascular fitness and quality of life more.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11352617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of an Aspiration Prevention Program That Utilizes the Gugging Swallowing Screen in Older Patients. 利用 Gugging 吞咽筛查对老年患者实施吸入预防计划的效果
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S474569
Ji Eun Song, Eunjeong Ji, Nak-Hyun Kim, Jung Hun Ohn, Yejee Lim, Jongchan Lee, Hye Won Kim, Sun-Wook Kim, Jiwon Ryu, Hee-Sun Park, Eun Sun Kim
{"title":"Efficacy of an Aspiration Prevention Program That Utilizes the Gugging Swallowing Screen in Older Patients.","authors":"Ji Eun Song, Eunjeong Ji, Nak-Hyun Kim, Jung Hun Ohn, Yejee Lim, Jongchan Lee, Hye Won Kim, Sun-Wook Kim, Jiwon Ryu, Hee-Sun Park, Eun Sun Kim","doi":"10.2147/CIA.S474569","DOIUrl":"10.2147/CIA.S474569","url":null,"abstract":"<p><strong>Purpose: </strong>Older patients have a higher risk of aspiration pneumonia and mortality if they are hospitalized. We aimed to assess the effectiveness of an aspiration prevention quality improvement (QI) program that utilizes the Gugging Swallowing Screen (GUSS) in older patients.</p><p><strong>Patients and methods: </strong>This retrospective cohort study was conducted in an acute medical care unit of a tertiary hospital in South Korea. The study used one-to-one propensity matching and included 96 patients who received the QI program and 96 who did not. All patients were aged 65 years or older and had risk factors for aspiration, including neurological and non-neurological disorders, neuromuscular disorders, impaired airway defenses, and dysphagia due to esophageal or gastrointestinal disorders. The primary outcomes included the duration of the fasting period during hospitalization, changes in nutritional status before admission and at discharge, in-hospital mortality, and readmission due to pneumonia within 90 days.</p><p><strong>Results: </strong>Fasting period, changes in weight and albumin levels upon discharge after hospitalization, and length of stay did not differ significantly between patients in the GUSS and non-GUSS groups. However, the risk of readmission within 90 days was significantly lower in patients who underwent the GUSS than in those who did not (hazard ratio, 0.085; 95% confidence interval, 0.025-0.290; p = 0.001).</p><p><strong>Conclusion: </strong>The GUSS aspiration prevention program effectively prevented readmission due to pneumonia within 90 days in older patients with acute illnesses. This implies that the adoption of efficient aspiration prevention methods in older patients with acute illnesses could play a pivotal role by enhancing patient outcomes and potentially mitigating the healthcare costs linked to readmissions.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurocognitive Features of Mild Cognitive Impairment and Distress Symptoms in Older Adults Without Major Depression. 轻度认知障碍的神经认知特征与无重度抑郁症老年人的苦恼症状。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S473730
Gallayaporn Nantachai, Michael Maes, Vinh-Long Tran-Chi, Solaphat Hemrungrojn, Chavit Tunvirachaisakul
{"title":"Neurocognitive Features of Mild Cognitive Impairment and Distress Symptoms in Older Adults Without Major Depression.","authors":"Gallayaporn Nantachai, Michael Maes, Vinh-Long Tran-Chi, Solaphat Hemrungrojn, Chavit Tunvirachaisakul","doi":"10.2147/CIA.S473730","DOIUrl":"10.2147/CIA.S473730","url":null,"abstract":"<p><strong>Background: </strong>Two distinct symptom dimensions were identified in older adults who did not have major depressive disorder (MDD): a) a dimension associated with mild cognitive dysfunction, and b) a dimension related to distress symptoms of old age (DSOA). It is uncertain whether previous findings regarding the features of amnestic mild cognitive impairment (aMCI) remain valid when patients with MDD are excluded.</p><p><strong>Methods: </strong>To examine the neurocognitive features of aMCI (n = 61) versus controls (n=59) and the objective cognitive characteristics of DSOA in participants without MDD. Neurocognition was evaluated utilizing the Cambridge Neurological Test Automated Battery (CANTAB) and memory tests.</p><p><strong>Results: </strong>This research demonstrated that CANTAB tests may differentiate between aMCI and controls. The One Touch Stockings of Cambridge, probability solved on first choice (OTS_PSFC), Rapid Visual Information Processing, A prime (RVP_ A´), and the Motor Screening Task, mean latency, were identified as the significant discriminatory CANTAB tests. 37.6% of the variance in the severity of aMCI was predicted by OTS_PSFC, RVP_ A´, word list recognition scores, and education years. Psychosocial stressors (adverse childhood experiences, negative life events), subjective feelings of cognitive impairment, and RVP, the probability of false alarm, account for 40.0% of the DSOA score.</p><p><strong>Discussion: </strong>When MDD is ruled out, aMCI is linked to deficits in attention, executive functions, and memory. Psychosocial stressors did not have a statistically significant impact on aMCI or its severity. Enhanced false alarm response bias coupled with heightened psychological stress (including subjective perceptions of cognitive decline) may contribute to an increase in DSOA among older adults.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the Home-Based Medical Integrated Program on Health Outcomes and Medical Resource Utilization in Home Healthcare Patients in Taiwan. 居家医疗整合计划对台湾居家医疗患者健康结果和医疗资源使用的影响。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S457281
Yu-Chieh Ho, Chia-Ti Wang, Tzu-Chieh Weng, Chung-Han Ho, Kang-Ting Tsai, Chien-Chin Hsu, Hung-Jung Lin, Hsiu-Chin Chen, Chien-Cheng Huang
{"title":"Impact of the Home-Based Medical Integrated Program on Health Outcomes and Medical Resource Utilization in Home Healthcare Patients in Taiwan.","authors":"Yu-Chieh Ho, Chia-Ti Wang, Tzu-Chieh Weng, Chung-Han Ho, Kang-Ting Tsai, Chien-Chin Hsu, Hung-Jung Lin, Hsiu-Chin Chen, Chien-Cheng Huang","doi":"10.2147/CIA.S457281","DOIUrl":"10.2147/CIA.S457281","url":null,"abstract":"<p><strong>Purpose: </strong>The home-based medical integrated program (HMIP) is a novel model for home healthcare (HHC) in Taiwan, initiated in 2016 to enhance care quality. However, the outcomes of this program on health outcomes and medical resource utilization in HHC patients remain unclear. Thus, we conducted this study to clarify it.</p><p><strong>Patients and methods: </strong>The authors utilized the Taiwan National Health Insurance Research Database to identify HHC patients who received HMIP and those who did not between January 2015 and December 2017. A retrospective cohort study design was used. Convenience sampling was employed to select patients who met the inclusion criteria: being part of the HHC program and having complete data for analysis.</p><p><strong>Results: </strong>A total of 4982 HHC patients in the HMIP group and 10,447 patients in the non-HMIP group were identified for this study. The mean age in the HMIP group and non-HMIP group was 77.6 years and 76.1 years, respectively. Compared with the non-HMIP group, the HMIP group had lower total medical costs for HHC, fewer outpatient department visits and lower medical costs, lower medical costs for emergency department visits, fewer hospitalizations, and a lower mortality rate (34.6% vs 41.2%, p<0.001).</p><p><strong>Conclusion: </strong>The HMIP is a promising model for improving care quality and reducing medical resource utilization in HHC patients. While this suggests that the non-HMIP model should be replaced, it's important to note that both non-HMIP and HMIP models currently coexist. The HMIP may serve as an important reference for other nations seeking to improve care quality and reduce medical resource utilization in their own HHC systems.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Analysis of Optic Disc Parameters in Patients with Peripheral Retinal Tears Following Acute Posterior Vitreous Detachment: A Cross-Sectional Study. 急性后玻璃体脱离后周边视网膜撕裂患者的视盘参数分析:一项横断面研究
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S466511
Darko Batistic, Ante Kreso, Josip Vrdoljak, Jaksa Batistic, Ivan Paladin, Ivan Mizdrak, Sandro Glumac
{"title":"An Analysis of Optic Disc Parameters in Patients with Peripheral Retinal Tears Following Acute Posterior Vitreous Detachment: A Cross-Sectional Study.","authors":"Darko Batistic, Ante Kreso, Josip Vrdoljak, Jaksa Batistic, Ivan Paladin, Ivan Mizdrak, Sandro Glumac","doi":"10.2147/CIA.S466511","DOIUrl":"10.2147/CIA.S466511","url":null,"abstract":"<p><strong>Background: </strong>To investigate association between optic disc parameters analyzed by optical coherence tomography (OCT) and occurrence of peripheral retinal tears in patients with symptomatic posterior vitreous detachment (PVD).</p><p><strong>Methods: </strong>This cross-sectional study enrolled 75 patients with symptoms of acute PVD, who were allocated into two groups based on whether a peripheral retinal tear occurred or not.</p><p><strong>Results: </strong>When comparing the average retinal nerve fiber layer (RNFL) thickness (μm) between retinal tear and control groups, it was shown that patients with a retinal tear have a significantly higher (87.18 [95% confidence interval (CI), 84.47 to 89.9] vs 81.14 [95% CI, 77.81 to 84.46], <i>P</i> = 0.005) average RNFL thickness. Furthermore, we observed a significant difference (0.13, 0.06 to 0.22 vs 0.07, 0.04 to 0.1, <i>P</i> = 0.036, Mann-Whitney <i>U</i>-test) in the size of cup volume (mm<sup>3</sup>) between the tear and control groups, respectively. Linear regression showed a significant decrease (<i>P</i> = 0.029) in average RNFL thickness with increasing age, but without a significant difference between the two groups. There was no statistically significant difference between the tear and control groups in terms of rim area, disc area, and average cup-to-disc ratio.</p><p><strong>Conclusion: </strong>Patients with a higher average RNFL thickness and larger cup volume measured by OCT were more prone to develop a peripheral retinal tear. Increased peripapillary average RNFL thickness due to trauma and subsequent inflammation, possibly related to the more adherent posterior hyaloid membrane to the retina, may also indicate strengthened adhesions in the areas of the peripheral retina where retinal tears occur. OCT analysis of the optic nerve head may be used in everyday clinical practice as a predictor of the development of peripheral retinal tears in patients with symptomatic PVD.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141477767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China. 丙二醛和锌可能与糖尿病微血管并发症的严重程度有关:中国东北地区老年 2 型糖尿病患者的初步研究》。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-06-26 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S464615
Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang
{"title":"Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China.","authors":"Min Sun, Guanchi Yan, Siming Sun, Xiaonan Li, Wei Sun, Yuehui Wang","doi":"10.2147/CIA.S464615","DOIUrl":"10.2147/CIA.S464615","url":null,"abstract":"<p><strong>Background: </strong>Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.</p><p><strong>Methods: </strong>The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.</p><p><strong>Results: </strong>There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (<i>P<0.05</i>). Iron (r<sub>Zinc</sub> = 0.147, r<sub>SOD</sub> = 0.180, r<sub>T-AOC</sub> = 0.193, <i>P < 0.05</i>) was positively correlated with zinc, SOD and T-AOC. Iron was negatively correlated with MDA (r<sub>MDA</sub> = -0.146, <i>P < 0.05</i>). Magnesium was positively correlated with SOD (r<sub>Magnesium</sub> = 0.147, <i>P < 0.05</i>). Zinc (r<sub>SOD</sub> = 0.616, r<sub>T-AOC</sub> = 0.575, <i>P < 0.01</i>) was positively correlated with SOD and T-AOC. Zinc (r<sub>MDA</sub> =-0.636, r<sub>NO</sub>=-0.616, <i>P<0.01</i>) was positively correlated with MDA and negatively correlated with NO. The course of disease (18.653, [5.726; 60.764], <i>P <0.01</i>), FBG (1.265, [1.059; 1.511], <i>P <0.05</i>), HbAlc (1.545, [1.431; 1.680], P <0.01), MDA (2.989, [1.900; 4.702], <i>P <0.01</i>) were risk factor for the severity of diabetic microvascular complications. Zinc (0.680, [0.503; 0.919], <i>P < 0.05</i>) and SOD (0.820, [0.698; 0.964], <i>P < 0.05</i>) were protective factors for the severity of diabetic microvascular complications.</p><p><strong>Conclusion: </strong>Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review of Falls Risk of Frail Patients with Dementia in Hospital: Progress, Challenges, and Recommendations. 关于住院老年痴呆症患者跌倒风险的系统性综述:进展、挑战和建议。
IF 3.5 3区 医学
Clinical Interventions in Aging Pub Date : 2024-06-25 eCollection Date: 2024-01-01 DOI: 10.2147/CIA.S400582
Naomi Davey, Eimear Connolly, Paul Mc Elwaine, Sean P Kennelly
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