Clinical Interventions in Aging最新文献

{"title":"Serum Peroxiredoxin 6 Levels and Clinical Outcomes After Acute Intracerebral Hemorrhage in Elderly Patients: A Multicenter Observational Analytical Study.","authors":"Tiancheng Lu, Boren Zheng, Dongyao Wang, Weihao Liao, Chang Su, Xiaoyu Wu, Xiaojun Zhong, Xinle Chen, Guozheng Ying, Yong Cai, Quan Du, Xiaoqiao Dong","doi":"10.2147/CIA.S582268","DOIUrl":"https://doi.org/10.2147/CIA.S582268","url":null,"abstract":"<p><strong>Background: </strong>Intracerebral hemorrhage (ICH) is commonly encountered in elderly patients. Peroxiredoxin 6 (Prx6) is involved in oxidative stress and inflammatory responses. Here, serum Prx6 levels were measured to explore their prognostic value in ICH.</p><p><strong>Methods: </strong>In this multicenter observational analytical study of 306 elderly patients with ICH and 100 elderly controls, serum Prx6 levels were quantified at admission of all patients, at serial time points of 103 patients and at study entry of controls. Outcome variables included early neurological deterioration (END) and poor neurological status mirrored by six-month modified Rankin Scale (mRS).</p><p><strong>Results: </strong>Serum Prx6 levels were significantly elevated upon admission of patients, gradually increased on day 1, peaked on day 3, decreased from day 5 until day 14 after ICH, and were markedly higher during 14 days than those of controls. Serum Prx6 levels, in independent correlation with National Institutes of Health Stroke Scale scores, hematoma sizes and mRS scores, were linearly related to risks of END and poor prognosis, and independently predicted their occurrences. The independent associations were robust in sensitivity analysis. The association between serum Prx6 levels and poor prognosis was partially mediated by END. Serum Prx6 levels showed an effective predictive ability for poor prognosis and END. Other parameters, such as age, gender, and hypertension, negligibly affected the relevance of Prx6 levels in poor prognosis and END. The combined models encompassing independent predictors were visualized via the nomograms and had acceptable goodness of fit and clinical benefit via various statistical tools.</p><p><strong>Conclusion: </strong>Elevated serum Prx6 levels post-ICH in the elderly are intimately related to bleeding severity and clinical outcomes; and END partially interprets the association of serum Prx6 with poor prognosis, therefore suggesting that serum Prx6 may be a prognostic biomarker of ICH in the elderly.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"582268"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147845037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis Screening in Primary Care: Early Implementation Gaps Following the 2023 Saudi Guideline Update.","authors":"Malak A Alshammari","doi":"10.2147/CIA.S605868","DOIUrl":"https://doi.org/10.2147/CIA.S605868","url":null,"abstract":"<p><strong>Objective: </strong>To assess adherence to the 2023 Saudi Osteoporosis Society (SOS) universal screening guideline among adults aged ≥60 years in an academic primary care center and identify factors associated with DEXA ordering.</p><p><strong>Methods: </strong>A retrospective EMR-based study included 2186 patients aged ≥60 years attending a university-affiliated primary care center (May 2023-December 2025). The primary outcome was adherence to SOS 2023 recommendations. Multivariable logistic regression identified predictors of BMD ordering.</p><p><strong>Results: </strong>BMD screening was ordered for 19.7% of eligible patients; only 4.1% completed testing. Screening was independently associated with female sex (aOR 5.26), prior osteoporosis (aOR 139.40), prior fracture (aOR 10.35), and female physician sex (aOR 1.50) (all p<0.05).</p><p><strong>Conclusion: </strong>Adherence to universal screening remains low, with a substantial gap between DXA ordering and completion, highlighting important implementation barriers in primary care practice.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"605868"},"PeriodicalIF":3.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate Analysis of Shock Risk and Model Development and Validation in Elderly Patients Following Hip Fracture Surgery in the Intensive Care Unit (ICU): A Retrospective Cohort Study.","authors":"Xue Wang, Zhen Cui, Mengqi Tong, Miaomiao Yu, Ying Bai","doi":"10.2147/CIA.S587505","DOIUrl":"https://doi.org/10.2147/CIA.S587505","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify risk factors for postoperative shock and develop and validate a predictive model based on preoperative variables in elderly patients undergoing hip fracture surgery.</p><p><strong>Patients and methods: </strong>We conducted a retrospective cohort study of elderly patients (>65 years) admitted to the ICU after hip fracture surgery in a single center between 2020 and 2024. Patients were stratified into shock (defined as a Shock Index ≥ 1.0) and non-shock groups. Data on demographics, comorbidities, and preoperative laboratory parameters were collected. Patients from 2020-2022 constituted the development cohort, which was randomly divided into training and internal validation sets at a ratio of 7:3, while patients from 2023-2024 formed the external validation cohort. Least absolute shrinkage and selection operator (LASSO) regression was used to identify candidate predictors, followed by multivariable logistic regression to construct the predictive model. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA).</p><p><strong>Results: </strong>A total of 740 patients were included, with 317 in the training cohort, 136 in the internal validation cohort, and 287 in the external validation cohort. LASSO regression identified four key predictors: body mass index (BMI), Charlson Comorbidity Index (CCI), hemoglobin (HGB), and albumin (ALB). These variables were incorporated into a nomogram. The nomogram demonstrated good discrimination and clinical utility, with AUC values of approximately 0.834 in the internal validation cohort and 0.801 in the external validation cohort. Decision curve analysis further supported its potential clinical benefit.</p><p><strong>Conclusion: </strong>We developed and validated a practical nomogram that effectively predicts the risk of postoperative shock in elderly hip fracture patients using four preoperative parameters. This model may assist clinicians in early risk stratification and perioperative monitoring of elderly hip fracture patients.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"587505"},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Severe Postoperative Complications After Laparoscopic Colorectal Cancer Surgery in Octogenarians: A Retrospective Cohort Study.","authors":"Yuegang Li, Jinbo Du, Wenlong Qiu, Jianqiang Tang","doi":"10.2147/CIA.S590287","DOIUrl":"https://doi.org/10.2147/CIA.S590287","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the incidence and risk factors of severe postoperative complications in patients aged ≥80 years undergoing laparoscopic colorectal cancer surgery.</p><p><strong>Patients and methods: </strong>Patients aged ≥80 years who underwent laparoscopic colorectal cancer surgery between February 2007 and September 2018. Severe complications were defined as Clavien-Dindo grade III or higher. Univariate and multivariate logistic regression analyses were performed to identify risk factors.</p><p><strong>Results: </strong>Among 170 patients, 26 (15.3%) experienced severe postoperative complications. Gastrointestinal events were most common (8.0%), followed by respiratory (3.5%) and cardiovascular (2.9%) complications. Two patients (1.2%) died postoperatively. Multivariate analysis identified estimated blood loss >100 mL (OR = 4.53, 95% CI: 1.75-11.70, <i>P</i> < 0.01) and age ≥85 years (OR = 4.48, 95% CI: 1.27-15.79, <i>P</i> = 0.02) as independent risk factors. Hemoglobin <120 g/L (OR = 2.56, 95% CI: 0.99-6.60, <i>P</i> = 0.05) and ASA III (OR = 2.49, 95% CI: 0.98-6.35, <i>P</i> = 0.06) showed borderline significance.</p><p><strong>Conclusion: </strong>Severe complications occurred in 15.3% of octogenarians undergoing laparoscopic colorectal cancer surgery. Age ≥85 years and intraoperative blood loss >100 mL were independent risk factors. Preoperative anemia and ASA III were borderline predictors. These factors may aid in perioperative risk stratification and surgical decision-making in elderly patients.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"590287"},"PeriodicalIF":3.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Postoperative Pulmonary Complications in Geriatric Patients with Hip Fracture Using Lung Ultrasonography Score and Diaphragmatic Mobility.","authors":"Xiaorui Han, Wen Chi, Peng Pang, Xiaobing Liu, Zhenguo Luo, Wenbo Cai, Li Zhang, Wangyang Li, Zhirong Wang, Jianhong Hao","doi":"10.2147/CIA.S603014","DOIUrl":"https://doi.org/10.2147/CIA.S603014","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative pulmonary complications (PPCs), common in geriatric patients with hip fractures, are associated with increased morbidity and mortality rates. Bedside ultrasonography may improve perioperative pulmonary risk stratification. This study aimed to evaluate the predictive value of the lung ultrasonography score (LUS) and diaphragmatic mobility (DM) for PPCs and identify the optimal index.</p><p><strong>Patients and methods: </strong>This prospective observational study included 192 geriatric patients with hip fractures who underwent surgery. One day preoperatively, LUS and DM were assessed at bedside. All patients received general anesthesia combined with a regional block and were followed up for 30 days postoperatively for the occurrence of PPCs. Receiver operating characteristic (ROC) curve analysis and multivariate logistic regression were used to evaluate predictive performance and adjust for confounders.</p><p><strong>Results: </strong>PPCs occurred in 28.64% (55/192) of the patients. LUS and DM exhibited moderate predictive efficacies for PPCs (LUS: AUC = 0.740, 95% CI: 0.653-0.826; DM: AUC = 0.733, 95% CI: 0.655-0.812). At a cutoff value of LUS > 5 cm, the negative predictive value reached 81.9%, and at a cutoff value of DM < 3.7 cm, the negative predictive value reached 87.6%. After multivariable adjustment, a LUS> 5 and DM < 3.7 cm remained independent predictors of PPCs (LUS > 5: adjusted OR = 6.363, 95% CI: 2.609-15.515; P < 0.001; DM < 3.7 cm: adjusted OR = 5.011, 95% CI: 2.106-11.923; P < 0.001). Integration of LUS (LUS > 5) and DM (DM < 3.7 cm) with ARISCAT significantly improved predictive performance (AUC = 0.851 with the integrated model vs. 0.684 with ARISCAT alone; DeLong's P < 0.001).</p><p><strong>Conclusion: </strong>LUS and DM effectively predicted PPCs in geriatric patients with hip fractures. The integration of LUS and DM with ARISCAT markedly enhances predictive accuracy, suggesting that lung and diaphragmatic ultrasound may serve as useful bedside tools for perioperative respiratory risk assessment.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"603014"},"PeriodicalIF":3.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older Adults and Healthcare Professional's Experiences of Telemonitoring in Primary Home-Based Care in Sweden: A Feasibility Study.","authors":"Maria Liljeroos, Anna Åkerberg, Marina Arkkukangas","doi":"10.2147/CIA.S595091","DOIUrl":"https://doi.org/10.2147/CIA.S595091","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, the older population is rapidly increasing and might be a challenge for healthcare providers in the future. Therefore, new methods of providing home-based care are urgently needed. Telemonitoring (TM) has been proposed to optimize patient care and enhance remote monitoring and management by clinicians. This feasibility study aimed to describe the experiences and perceptions of home-based TM among older adults with chronic conditions and healthcare professionals (HCPs).</p><p><strong>Methods: </strong>A feasibility study including interviews with older adults and diaries written by HCPs during the intervention. Participants were recruited from two municipalities in central Sweden. The intervention involved home-based TM for 4 months. TM systems, equipped with sensors for monitoring blood pressure, body weight, physical activity, and oxygen saturation, were tailored to individual needs and installed in participants' homes by an IT company. Data were collected between 2023 and 2024 and analysed using deductive content analysis regarding demand, acceptability, implementation and practicality, to examine whether TM is feasible in real-life settings.</p><p><strong>Results: </strong>The data collection included 12 older adults and 21 healthcare professionals. From interviews with older adults (n=4), and diaries (n=9) from HCPs. Older adults measured their blood pressure every morning and entered the data on a tablet. They reported becoming more aware of changes in their health, particularly with body weight and blood pressure. For sustained engagement and motivation, a comprehensive education plan for TM involving patients, relatives, and HCP is essential.</p><p><strong>Conclusion: </strong>This study indicates that raising health awareness among older adults is positive and underscores the importance of person-centered care. However, some aspects were not fully realized in our study, highlighting the need for further research and refinement in TM implementation to better meet the needs of older adults and healthcare professionals.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04955600 registration date 2021-03-01.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"595091"},"PeriodicalIF":3.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Photostimulation Therapy in Cognitive Function of Alzheimer's Disease Patients: A Scoping Review.","authors":"Bixuan Xu, Hejia Wan, Ping Liu, Zilin Zhao, Yulu Xie, Jiaru Meng, Yuanmei Qin","doi":"10.2147/CIA.S600468","DOIUrl":"https://doi.org/10.2147/CIA.S600468","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease patients often experience cognitive decline during disease progression, impacting their quality of life. Photostimulation therapy, as a non-invasive neuromodulation method, has been increasingly used in the adjunctive management of Alzheimer's patients in recent years. Despite the increasing number of related studies, a systematic review and comprehensive evaluation are still lacking.</p><p><strong>Objective: </strong>This review systematically summarizes the current application of photostimulation therapy in Alzheimer's disease patients, outlines its implementation characteristics, outcome indicators, intervention effects and mechanisms of action in cognitive function intervention, and identifies evidence gaps in current research.</p><p><strong>Methods: </strong>Relevant studies were systematically retrieved from PubMed, Web of Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, WanFang Database, and VIP Database from their inception to January 5, 2026. Data from the included literature were extracted and analyzed.</p><p><strong>Results: </strong>A total of 21 studies were included. Photostimulation therapy primarily includes light stimulation, 40 Hz rhythm-related light stimulation, photobiological modulation and their combined therapies, as well as transcatheter intracranial laser therapy. This therapy has potential value in improving cognitive function or delaying cognitive decline and may affect sleep/rhythm and behavioral symptoms. Its potential mechanisms involve neural oscillation modulation, circadian rhythm reconstruction, and improvement of synaptic plasticity. However, existing evidence exhibits significant heterogeneity in study design, sample size, intervention parameters, and outcome indicators.</p><p><strong>Conclusion: </strong>Photostimulation therapy has shown promising potential in cognitive function intervention for Alzheimer's disease patients, but current evidence is still largely in the exploratory stage. Future research should focus on multi-center, large-sample, and standardized studies to determine the optimal parameter combinations for different stages and scenarios, and to optimize individualized intervention protocols to improve clinical efficacy.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"600468"},"PeriodicalIF":3.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Non-Operative versus Operative Management and Mortality in Elderly Patients with Hip Fracture: A Retrospective Cohort Study.","authors":"Lan Jiang, Ling Zhu, Yifeng Jin, Meirong Yao","doi":"10.2147/CIA.S572082","DOIUrl":"https://doi.org/10.2147/CIA.S572082","url":null,"abstract":"<p><strong>Objective: </strong>To compare outcomes between non-operative and operative management of hip fractures in elderly patients.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study (January 2018-December 2022), we enrolled 298 elderly patients with hip fractures after excluding 704 from an initial 1,002 consecutive cases. This study excluded patients with old fractures, other types of fractures, lack of data on injury reason, and absence of follow-up data. Multivariable logistic regression was used to explore the association between different treatment and mortality, adjusting for age, gender, injury reason, fracture type, hypertension, and diabetes. Subgroup analyses were employed to assess the association between the different treatments and mortality.</p><p><strong>Results: </strong>Among the 298 elderly patients with hip fractures, 59 were managed non-operatively and 239 underwent surgery. The overall 1-year mortality rate was 14.43% (43/298). Mortality was 25.42% (15/59) in the non-operative group and 11.72% (28/239) in the operative group. After adjustment, surgical management reduced mortality risk by 61% (OR =0.39, 95% CI:0.19-0.82, P = 0.013). Subgroup analysis demonstrated significant benefit in patients < 80 years (87% risk reduction; OR = 0.13, 95% CI: 0.04-042), whereas no significant association was observed in ≥ 80-year-olds (OR = 0.85, 95% CI:0.32-2.80, P for interaction = 0.023).</p><p><strong>Conclusion: </strong>Our analysis indicates an association between operative management and reduced mortality risk in elderly hip fracture patients. This benefit was observed to be more marked in individuals aged under 80 years. While consistent with existing observational studies, these findings merit confirmation through randmised controlled trials, particularly to determine optimal management strategies for the oldest old (≥80 years).</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"572082"},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a High Visceral Adiposity Phenotype: A Cluster Analysis-Based Stratification of NAFLD Risk in the Elderly.","authors":"Zhongjun Shen, Qian Zhang, Jingjin Tao, Yuying Nie, Qi Liu, He Wang, Zhongxin Li, Chong Wang, Shuo Yang, Liyan Cui","doi":"10.2147/CIA.S595432","DOIUrl":"https://doi.org/10.2147/CIA.S595432","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disease globally, is closely linked to obesity and metabolic dysregulation. However, the relative contributions of overall adiposity versus body fat distribution patterns to NAFLD pathogenesis, particularly in the elderly population, remain incompletely understood.</p><p><strong>Objective: </strong>This study aimed to investigate the association between cluster-derived body composition phenotypes and NAFLD risk, and identify independent risk factors for NAFLD.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 239 elderly participants. Body composition parameters (whole-body and regional fat percentages, visceral adipose tissue (VAT) area, fat-free mass) were measured via dual-energy X-ray absorptiometry (DXA). Participants were divided into NAFLD and non-NAFLD groups by abdominal ultrasonography. Inter-group comparisons were performed with Student's t-tests and chi-square tests. Cluster analysis was applied to identify distinct body composition phenotypes. Univariate and multivariate logistic regression were used to screen independent NAFLD risk factors, and ROC curve analysis evaluated the model's predictive performance.</p><p><strong>Results: </strong>The NAFLD group showed more prominent central obesity (<i>P</i><0.001) and higher fat-free mass (<i>P</i><0.001) than the non-NAFLD group, with no difference in total body fat percentage. Three phenotypes were identified: high total fat with limb-dominant distribution (C1), high visceral fat with central obesity (C2), and low total fat with symmetrical distribution (C3). C2 had the worst metabolic profile and highest NAFLD prevalence (60.5%), significantly higher than C1 (27.5%) and C3 (30.3%). Multivariate analysis identified lower HDL-C, higher BMI, elevated trunk-to-leg fat ratio, and higher albumin as independent NAFLD predictors; the four-indicator combined model had optimal predictive performance (AUC=0.803).</p><p><strong>Conclusion: </strong>In the elderly, visceral fat accumulation and central fat distribution, rather than overall adiposity itself, are key body composition features linked to NAFLD. The high visceral fat central obesity phenotype correlates with the highest metabolic risk and NAFLD prevalence, and the trunk-to-leg fat ratio is a robust NAFLD predictor.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"595432"},"PeriodicalIF":3.7,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Postoperative Subacromial Impingement Syndrome and Functional Recovery After Arthroscopic Rotator Cuff Repair in Elderly Patients: A Single-Center Retrospective Study.","authors":"Bo Jin, Weifan Ren, Jingjing Wang, Yungen Hu","doi":"10.2147/CIA.S600526","DOIUrl":"https://doi.org/10.2147/CIA.S600526","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical characteristics of postoperative subacromial impingement syndrome (SIS) in elderly patients undergoing arthroscopic rotator cuff repair (RCR) and to analyze its association with mid- to long-term postoperative functional recovery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 150 elderly patients who underwent RCR between January 2023 and January 2025. Patients were stratified into an impingement group (n = 32) and a non-impingement group (n = 118) based on the presence of SIS at 3 months postoperatively. Preoperative baseline characteristics, surgery-related variables, and postoperative outcomes including the Constant-Murley Shoulder Score (CMS), the University of California, Los Angeles Shoulder Score (UCLA), and the Visual Analog Scale for pain (VAS) were compared between the two groups at 3, 6, and 12 months after surgery.</p><p><strong>Results: </strong>At 3 months postoperatively, the incidence of SIS was 21.33% (32/150). The affected patients mainly presented with aggravated shoulder pain during abduction and forward flexion, with 100% positive Neer impingement test and 90.63% positive Hawkins impingement test, and some patients had audible clicking during shoulder movement. At 3, 6, and 12 months after surgery, CMS and UCLA scores were significantly lower in the impingement group than in the non-impingement group, while VAS scores were significantly higher (all <i>P</i> < 0.05), Cohen's d values for CMS at 0.55, 0.35, 0.59; for UCLA at 1.21, 0.41, 0.48; and for VAS at 0.42, 0.81, 0.63 (moderate to large effect sizes) indicating a substantial magnitude of intergroup differences. Although CMS and UCLA scores demonstrated a progressive improvement over time and VAS scores showed a continuous decline in both groups, the overall recovery level in the impingement group remained consistently inferior to that of the non-impingement group throughout the follow-up period.</p><p><strong>Conclusion: </strong>The incidence of SIS after RCR in elderly patients is relatively high, and the postoperative SIS in this population is characterized by aggravated shoulder pain during abduction and forward flexion, positive Neer and Hawkins impingement tests, and occasional audible clicking during shoulder movement. Postoperative SIS was significantly associated with poorer shoulder functional recovery and delayed pain relief in elderly patients undergoing arthroscopic rotator cuff repair.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":"21 ","pages":"600526"},"PeriodicalIF":3.7,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13108491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}