Korean Journal of Internal Medicine最新文献_第3页

Sex differences in diagnosis and treatment of heart failure: toward precision medicine. 心力衰竭诊断和治疗的性别差异：走向精准医学。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.338

Soo Yong Lee, Seong-Mi Park

{"title":"Sex differences in diagnosis and treatment of heart failure: toward precision medicine.","authors":"Soo Yong Lee, Seong-Mi Park","doi":"10.3904/kjim.2024.338","DOIUrl":"10.3904/kjim.2024.338","url":null,"abstract":"There are sex-related differences in the pathophysiology and phenotype of heart failure (HF) as well as the pharmacokinetics and pharmacodynamics of drugs between women and men due to biological differences, such as heart and vessel size, response to blood volume and pressure, body water and muscle compositions, and dominant sex hormones. Therefore, target drug doses required to achieve the same clinical effect differ between the sexes, while there may also be sex-related differences in side effects of a given drug at the same dose. These biological differences have been reflected in the results of clinical trials. Moreover, women have been underrepresented in pharmacological therapy trials as well as having lower device implantation rates than men. Therefore, the currently recommended target doses of medications based on clinical trials may not be appropriate for women. Although guidelines for HF have been standardized since the last major revision in 2021, most do not differentiate by sex. This review focuses on evidence regarding sex-related differences in multiple aspects of HF, including epidemiology, pathophysiology, clinical features, treatment, and prognosis, highlighting the need for sex-specific treatment guidelines.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"196-207"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of endoscopic ultrasound in the diagnosis and local ablative therapy of pancreatic neuroendocrine tumors. 内窥镜超声在胰腺神经内分泌肿瘤的诊断和局部消融治疗中的作用。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.3904/kjim.2024.293

Yun Je Song, Jun Kyeong Lim, Jun-Ho Choi

引用次数: 0

Fatty liver index and development of lung cancer: a nationwide cohort study. 脂肪肝指数与肺癌发病：一项全国性队列研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-10-22 DOI: 10.3904/kjim.2024.232

Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim

{"title":"Fatty liver index and development of lung cancer: a nationwide cohort study.","authors":"Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim","doi":"10.3904/kjim.2024.232","DOIUrl":"10.3904/kjim.2024.232","url":null,"abstract":"Background/aims: This study aimed to evaluate the impact of steatotic liver disease severity on the cumulative incidence of lung cancer utilizing data from the Korea National Health Insurance Service (NHIS).Methods: This study examined the risk of lung cancer in the general population in conjunction with the incidence of steatotic liver disease. The study population consisted of 3,261,438 individuals aged 20 years or older who underwent a general health examination in 2009.Results: Individuals with fatty liver index (FLI) of 30-59 exhibited a 1.08-fold increased risk of lung cancer (95% CI: 1.04-1.11), while FLI ≥ 60 was associated with a 1.22-fold elevated risk of lung cancer (95% CI: 1.17-1.28) compared to those with FLI < 30. The risk varied with smoking status; in current smokers, the adjusted HR for the FLI 30-59 group was 1.05 (95% CI: 1.00-1.10), while that in the FLI ≥ 60 group was 1.11 (95% CI: 1.04-1.18). In never- or past-smokers, the adjusted HR for the FLI 30-59 group was 1.10, and that for the FLI ≥ 60 group was 1.31. Subgroup analysis revealed an incidence rate of 1.06 per 1,000 person-years in the consistently high FLI group compared to 1.15 in those with improved FLI. Improving FLI over time was associated with a 0.93-fold decrease in lung cancer risk.Conclusion: Our study demonstrated a correlational relationship between lung cancer incidence and the severity of steatotic liver disease as measured by FLI.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"275-285"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19. 血清克雷布斯·冯·登·伦根-6初始和峰值水平对COVID-19患者预后的预测

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.3904/kjim.2024.161

Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim

{"title":"Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19.","authors":"Geonui Kim, Hyeonwoo Kwon, Sang Hyun Ra, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim","doi":"10.3904/kjim.2024.161","DOIUrl":"10.3904/kjim.2024.161","url":null,"abstract":"Background/aims: Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and peak serum KL-6 levels to predict mortality and evaluated their correlation with mortality.Methods: This retrospective cohort study collected data on serially collected serum KL-6 levels in patients hospitalized with COVID-19 between October 2020 and January 2022 at a single tertiary hospital in South Korea. The area under the receiver operating characteristic curve and Youden index were used to determine the cutoff points for the initial and peak KL-6 levels that best predicted 30-day mortality. The association between the initial and peak KL-6 values was assessed by univariate and multivariate logistic regression models.Results: A total of 349 patients were included in this study. The mean initial and peak KL-6 levels were significantly higher in the non-survivor group than in the survivor group. The initial and peak KL-6 values that best predicted 30-day mortality were 491.85 U/mL and 660.05 U/mL, respectively. An initial KL-6 level greater than 491.85 U/mL and a peak KL-6 level greater than 660.05 U/mL were significantly associated with 30-day mortality.Conclusion: The initial and peak levels of KL-6 were significantly associated with 30-day mortality in hospitalized patients with COVID-19. These findings suggest that serially monitoring blood KL-6 levels could be a valuable prognostic indicator for COVID-19.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"321-329"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years. 80岁以上患者食管鳞状细胞癌的临床结果分析。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.3904/kjim.2024.201

Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son

{"title":"Clinical outcomes of esophageal squamous cell carcinoma in patients aged over 80 years.","authors":"Dae Gon Ryu, Cheol Woong Choi, Su Jin Kim, Su Bum Park, Jin Ook Jang, Bong Soo Son","doi":"10.3904/kjim.2024.201","DOIUrl":"10.3904/kjim.2024.201","url":null,"abstract":"Background/aims: The clinical outcomes and optimal treatment of esophageal squamous cell carcinoma (ESCC) in elderly patients are unclear. This study aimed to assess the clinical outcomes of ESCC in patients aged ≥ 80 years.Methods: Medical records of patients diagnosed with ESCC between December 2008 and February 2024 were retrospectively reviewed. In total, 479 patients with ESCC were included and divided into the elderly (n = 52) and younger (n = 427) groups based on age. The clinical outcomes and survival rates, according to treatment, were compared between the two groups.Results: The median ages of the two groups were 82 years (range, 80-95 yr) and 66 years (41-79 yr). The overall survival was slightly lower in the elderly group; however, no statistical significance (hazard ratio [HR] 1.27, 95% confidence interval [CI] 0.85-1.91; p = 0.238) was observed. No differences were observed in the outcomes or survival between the two groups according to the treatment method (surgery, chemoradiotherapy or radiotherapy alone, and endoscopic resection). The elderly group was more likely to receive no treatment for cancer (30.8% vs. 13.6%, p = 0.002) than the younger group. However, when there was no treatment for cancer in the elderly group, survival was significantly lower than when treatment was administered (HR 0.08, 95% CI 0.03-020; p < 0.001).Conclusion: In patients with ESCC aged ≥ 80 years, active cancer treatment was beneficial, and the results did not differ from those of younger patients.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"230-242"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment strategies for octogenarians with esophageal cancer: changing age-based treatment paradigms. 八十多岁食管癌患者的治疗策略：改变基于年龄的治疗模式。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2025.029

Jaewon Hyung

引用次数: 0

Sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome: a comparative study of 2018-2019 and 2020-2021. 2019冠状病毒病疫情对代谢综合征发病率的性别特异性影响：2018-2019年和2020-2021年的比较研究

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.288

Kyeong-Hyeon Chun, Hyun-Jin Kim, Dae Ryong Kang, Jang Young Kim, Wonjin Kim, Yong Whi Jeong, Seung Hwan Han, Kwang Kon Koh

{"title":"Sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome: a comparative study of 2018-2019 and 2020-2021.","authors":"Kyeong-Hyeon Chun, Hyun-Jin Kim, Dae Ryong Kang, Jang Young Kim, Wonjin Kim, Yong Whi Jeong, Seung Hwan Han, Kwang Kon Koh","doi":"10.3904/kjim.2024.288","DOIUrl":"10.3904/kjim.2024.288","url":null,"abstract":"Background/aims: The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health, exacerbated metabolic health issues, and altered lifestyle behaviors. This study examined the sex-specific impact of the COVID-19 outbreak on the incidence of metabolic syndrome using data from the Korea National Health and Nutrition Examination Survey (KNHANES).Methods: Data from the KNHANES VII (2018) and VIII (2019-2021), including 15,499 participants, were analyzed. The study population was stratified by sex, and further subdivisions were conducted based on the timeframe relative to the COVID-19 outbreak. Variables such as age, education level, household income, smoking status, and high-risk drinking were analyzed to assess their influence on the prevalence of metabolic syndrome.Results: The overall prevalence of metabolic syndrome significantly increased from 28.11% before the outbreak to 29.69% after the outbreak. Both males and females reported significant increases in waist circumference and fasting glucose levels. Age and education level differentially influenced the prevalence of metabolic syndrome between the sex. Smoking was significantly associated with increased prevalence in males, whereas high-risk drinking was associated with increased prevalence in males and decreased prevalence in females.Conclusion: The COVID-19 pandemic has significantly increased the prevalence of metabolic syndrome with notable sex-specific differences. These findings highlight the need for sex-specific public health interventions to mitigate the impact of the pandemic on metabolic health.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"262-274"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives on interstitial lung abnormalities. 间质性肺异常的当前观点。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 DOI: 10.3904/kjim.2024.335

Ju Hyun Oh, Jin Woo Song

{"title":"Current perspectives on interstitial lung abnormalities.","authors":"Ju Hyun Oh, Jin Woo Song","doi":"10.3904/kjim.2024.335","DOIUrl":"10.3904/kjim.2024.335","url":null,"abstract":"Interstitial lung abnormalities (ILAs) are early indicators of interstitial lung disease, often identified incidentally via computed tomography of the chest. This review explores the diagnostic criteria for ILAs as outlined by the Fleischner Society, highlights associated risk factors, examines their impact on patient outcomes, and discusses management strategies. The prevalence of ILAs varies significantly, ranging from 3% to 17% across populations. Key risk factors include advanced age, smoking status, and underlying genetic predispositions. Recent advancements in imaging analysis, particularly through automated quantitative systems, have enhanced the accuracy of ILA detection. Although often subtle in presentation, ILAs hold clinical significance due to their associations with impaired lung function, progressive fibrosis, and increased mortality. Therefore, monitoring and management plans should be individualized to the risk profile of patients. Further studies are needed to refine ILA diagnostic criteria, enhance our understanding of their clinical implications, and establish optimal timing for therapeutic interventions.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 2","pages":"208-218"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute gouty arthritis of the atlantoaxial joint. 寰枢关节急性痛风性关节炎。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-21 DOI: 10.3904/kjim.2024.247

Su Jin Choi, Min Wook So, Sunggun Lee, Seung Won Choi, Doo-Ho Lim

引用次数: 0

Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea. 韩国炎症性肠病患者门静脉血栓形成的特点和结局。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.3904/kjim.2024.181

Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park

{"title":"Characteristics and outcomes of portal vein thrombosis in patients with inflammatory bowel disease in Korea.","authors":"Ki Jin Kim, Su-Bin Song, Jung-Bin Park, June Hwa Bae, Ji Eun Baek, Ga Hee Kim, Min-Jun Kim, Seung Wook Hong, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Chang Sik Yu, Yong-Sik Yoon, Jong-Lyul Lee, Min Hyun Kim, Ho-Su Lee, Sang Hyoung Park","doi":"10.3904/kjim.2024.181","DOIUrl":"10.3904/kjim.2024.181","url":null,"abstract":"Background/aims: Portal vein thrombosis (PVT) frequently occurs in patients with inflammatory bowel disease (IBD), particularly when influenced by factors such as abdominal infections, IBD flare-ups, or surgical procedures. The implications of PVT range from immediate issues such as intestinal ischemia to long-term concerns including portal hypertension and its complications. However, there is a notable gap in comprehensive studies on PVT in IBD, especially with the increasing incidence of IBD in Asia. This research aimed to evaluate the clinical features and outcomes of PVT in patients with IBD at a leading hospital in South Korea.Methods: This retrospective analysis reviewed adult patients diagnosed with both IBD and PVT from 1989 to 2021 at a renowned South Korean medical center. The study focused on patient characteristics, specifics of PVT, administered treatments, and outcomes, all confirmed through enhanced CT scans.Results: A total of 78 patients met the study's criteria. Notably, only 20.5% (16/78) were treated with oral anticoagulants; however, a vast majority (96.2%; 75/78) achieved complete radiographic resolution (CRR). When comparing patients receiving anticoagulants to those who did not, a significant preference for anticoagulant use was observed in cases where the main portal vein was affected, as opposed to just the left or right veins (p = 0.006). However, multivariable analysis indicated that neither anticoagulant use nor previous surgeries significantly impacted CRR.Conclusion: Patients with IBD and PVT generally had favorable outcomes, regardless of anticoagulant use.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"243-250"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0