Korean Journal of Internal Medicine最新文献_第3页

Current status of modifiable risk factors for cardiovascular disease in Korean women. 韩国妇女心血管疾病可改变风险因素的现状。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-10-22 DOI: 10.3904/kjim.2024.077

In-Jeong Cho, Mi-Seung Shin

引用次数: 0

Prevalence and risk factors for gallstone and renal stone formation in patients with intestinal Behçet's disease. 肠道白塞氏病患者胆石和肾结石形成的发病率和风险因素。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.3904/kjim.2024.006

Jaewon Song, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jihye Park, Jae Hee Cheon

{"title":"Prevalence and risk factors for gallstone and renal stone formation in patients with intestinal Behçet's disease.","authors":"Jaewon Song, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jihye Park, Jae Hee Cheon","doi":"10.3904/kjim.2024.006","DOIUrl":"10.3904/kjim.2024.006","url":null,"abstract":"Background/aims: The association between inflammatory bowel disease (IBD) and gallstone and renal stone formation has been established. However, few studies have investigated this association in patients with intestinal Behçet's disease (BD). We aimed to examine the prevalence of gallstones and renal stones in patients with intestinal BD and identify potential risk factors.Methods: We analyzed gallstone and renal stone occurrences in 553 patients diagnosed with intestinal BD who had undergone cross-sectional imaging examinations between March 2005 and April 2021 at the IBD Center, Severance Hospital, Seoul, South Korea. Logistic regression models were used to identify risk factors for gallstone and renal stone formation.Results: Of 553 patients over a mean 12.1-year duration, 141 (25.4%) patients had gallstones and 35 (6.3%) had renal stones. In multivariate logistic regression analysis, disease duration > 19 years (OR 2.91, 95% CI 1.56-5.44, 0.002). No significant correlation 0.001), prior intestinal BD-related surgery (OR 2.29, 95% CI 1.42-3.68, p < 0.001), and disease activity index for intestinal BD scores ≥ 75 (OR 2.23, 95% CI 1.12-4.45, p = 0.022) were associated with increased gallstone occurrence. A positive correlation was observed between renal stones, disease duration > 19 years (OR 5.61, 95% CI 1.98-15.90, p = 0.001) and frequent hospitalization (> 3 times) (OR 3.29, 95% CI 1.52-7.13, p = 0.002). No significant correlation was observed between gallstone and renal stone occurrence.Conclusion: These findings contribute to greater understanding concerning gallstone and renal stone prevalence and associated risk factors in patients with intestinal BD.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"770-782"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High vegetable consumption and regular exercise are associated with better quality of life in patients with gout. 多吃蔬菜和经常锻炼与痛风患者生活质量的提高有关。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.3904/kjim.2023.476

Hyunsue Do, Hyo Jin Choi, Byoongyong Choi, Chang-Nam Son, Sang-Hyon Kim, You-Jung Ha, Ji Hyoun Kim, Min Jung Kim, Kichul Shin, Hyun-Ok Kim, Ran Song, Sung Won Lee, Joong Kyong Ahn, Seung-Geun Lee, Chang Hoon Lee, Kyeong Min Son, Ki Won Moon

{"title":"High vegetable consumption and regular exercise are associated with better quality of life in patients with gout.","authors":"Hyunsue Do, Hyo Jin Choi, Byoongyong Choi, Chang-Nam Son, Sang-Hyon Kim, You-Jung Ha, Ji Hyoun Kim, Min Jung Kim, Kichul Shin, Hyun-Ok Kim, Ran Song, Sung Won Lee, Joong Kyong Ahn, Seung-Geun Lee, Chang Hoon Lee, Kyeong Min Son, Ki Won Moon","doi":"10.3904/kjim.2023.476","DOIUrl":"10.3904/kjim.2023.476","url":null,"abstract":"Background/aims: The Gout Impact Scale (GIS), a part of the Gout Assessment Questionnaire 2.0, is used to measure gout-specific health-related quality of life (HRQOL). Although several studies have been conducted on the factors affecting the HRQOL of patients with gout, few have focused on lifestyle factors. This study aimed to investigate the correlation between lifestyle habits and HRQOL using the GIS in patients with gout.Methods: We used data from the Urate-Lowering TheRApy in Gout (ULTRA) registry, a prospective cohort of Korean patients with gout treated at multiple centers nationwide. The patients were aged ≥18 years and met the 2015 American College of Rheumatology/European League Against Rheumatism gout classification criteria. They were asked to complete a GIS and questions regarding their lifestyle habits at enrollment.Results: The study included 232 patients. 'Gout concern overall' scores in the GIS were significantly lower in patients who exercised more frequently and consumed soft drinks and meat less, and 'well-being during attack' scores were significantly lower in patients who consumed vegetables and exercised more frequently. The frequency of vegetable consumption had a negative linear relationship with the 'well-being during attack' and 'gout concern during attack' scores (p = 0.01, p = 0.001, respectively). The frequency of exercise had a negative linear relationship with the 'gout concern overall' and 'gout concern during attack' scores (p = 0.04 and p = 0.002, respectively).Conclusion: Patients with gout who frequently consumed vegetables and exercised regularly experienced less impact of gout, exhibiting a better GIS that represented HRQOL.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"845-854"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of hormonal changes in hypophysitis by immune checkpoint inhibitor. 免疫检查点抑制剂对肾上腺皮质功能减退症的荷尔蒙变化模式。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.3904/kjim.2023.523

Hyunji Sang, Yun Kyung Cho, Sang-Hyeok Go, Hwa Jung Kim, Eun Hee Koh

{"title":"Patterns of hormonal changes in hypophysitis by immune checkpoint inhibitor.","authors":"Hyunji Sang, Yun Kyung Cho, Sang-Hyeok Go, Hwa Jung Kim, Eun Hee Koh","doi":"10.3904/kjim.2023.523","DOIUrl":"10.3904/kjim.2023.523","url":null,"abstract":"Background/aims: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events, including endocrine dysfunctions, which can have serious consequences on patient health and quality of life. The clinical course and characteristics of immune-related hypophysitis (irH) are not well established. This study aimed to analyze the clinical course and characteristics of irH.Methods: This single-center, retrospective study analyzed data from electronic medical records of Asan Medical Center, spanning January 2017 through June 2021. It included adult patients with solid tumors who underwent thyroid and adrenal function tests, along with gonadotropin and/or growth hormone evaluations, following the initiation of ICI treatment within the same period. The study explored the clinical characteristics of ICI-treated patients with and without irH, the incidence of irH, the time to irH onset, and the associated hormonal changes.Results: Twenty-one patients were included in this analysis. Clinical characteristics did not differ significantly between the irH (n = 13) and non-irH (n = 8) groups. Deficiency rates in the irH group were 23.1% for thyroid-stimulating hormone (n = 3), 76.9% for adrenocorticotropic hormone (n = 10), 61.5% for gonadotropin (n = 8), and 15.4% for growth hormone (n = 2). The overall incidence was 0.9 per person-year, with 6-month and 1-year cumulative incidences of 38.8% and 57.1%, respectively. The median time from ICI initiation to irH diagnosis was 7.7 months. Time to levothyroxine replacement was shorter in the irH group.Conclusion: The findings provide evidence that could facilitate the prediction of ICI-induced irH based on clinical course and characteristics.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"39 5","pages":"801-812"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of esophagogastric junctional outlet obstruction caused by thoracic aortic aneurysm. 一例由胸主动脉瘤引起的食管胃交界出口梗阻。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-22 DOI: 10.3904/kjim.2024.084

Jin Ook Jang, Tae Un Kim, Hwaseong Ryu, Byung-Soo Park, Su Jin Kim

引用次数: 0

Clinical effects of non-pharmaceutical interventions for COVID-19 on other nationally notifiable infectious diseases in South Korea. 针对 COVID-19 的非药物干预措施对韩国其他国家通报传染病的临床影响。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI: 10.3904/kjim.2023.501

Hyun-Jin Lee, Beom Seuk Hwang, Seong Ho Im, Seog-Kyun Mun, Munyoung Chang

{"title":"Clinical effects of non-pharmaceutical interventions for COVID-19 on other nationally notifiable infectious diseases in South Korea.","authors":"Hyun-Jin Lee, Beom Seuk Hwang, Seong Ho Im, Seog-Kyun Mun, Munyoung Chang","doi":"10.3904/kjim.2023.501","DOIUrl":"10.3904/kjim.2023.501","url":null,"abstract":"Background/aims: This study aimed to assess the impact of non-pharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic on nationally notifiable infectious diseases (NNIDs) in South Korea.Methods: Long-term data on seven NNIDs from 2018 to 2021 were analyzed to identify trends and change points using a change point detection technique. The timings of the NPI implementations were compared to the identified change points to determine their association.Results: Varicella, mumps, and scarlet fever showed a significant decrease in incidence following the implementation of NPIs during the COVID-19 pandemic. These diseases, which are primarily transmitted through respiratory droplets, demonstrated a clear response to NPIs. However, carbapenem-resistant Enterobacterales (CRE) showed an increasing trend unrelated to the timing of NPI implementation, suggesting the complex nature of controlling healthcare-associated infections. Hepatitis A, hepatitis C, and scrub typhus did not show significant changes associated with NPIs, likely due to their non-respiratory route of transmission.Conclusion: NPIs effectively controlled NNIDs, particularly those transmitted through respiratory infections. However, the impact varied depending on the disease. Understanding the effectiveness and limitations of NPIs is crucial for developing comprehensive public health strategies during infectious disease outbreaks.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"823-832"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches. 肠道微生物群失调及其对哮喘和其他肺部疾病的影响：潜在的治疗方法。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.3904/kjim.2023.451

Young-Chan Kim, Kyoung-Hee Sohn, Hye-Ryun Kang

{"title":"Gut microbiota dysbiosis and its impact on asthma and other lung diseases: potential therapeutic approaches.","authors":"Young-Chan Kim, Kyoung-Hee Sohn, Hye-Ryun Kang","doi":"10.3904/kjim.2023.451","DOIUrl":"10.3904/kjim.2023.451","url":null,"abstract":"The emerging field of gut-lung axis research has revealed a complex interplay between the gut microbiota and respiratory health, particularly in asthma. This review comprehensively explored the intricate relationship between these two systems, focusing on their influence on immune responses, inflammation, and the pathogenesis of respiratory diseases. Recent studies have demonstrated that gut microbiota dysbiosis can contribute to asthma onset and exacerbation, prompting investigations into therapeutic strategies to correct this imbalance. Probiotics and prebiotics, known for their ability to modulate gut microbial compositions, were discussed as potential interventions to restore immune homeostasis. The impact of antibiotics and metabolites, including short-chain fatty acids produced by the gut microbiota, on immune regulation was examined. Fecal microbiota transplantation has shown promise in various diseases, but its role in respiratory disorders is not established. Innovative approaches, including mucus transplants, inhaled probiotics, and microencapsulation strategies, have been proposed as novel therapeutic avenues. Despite challenges, including the sophisticated adaptability of microbial communities and the need for mechanistic clarity, the potential for microbiota-based interventions is considerable. Collaboration between researchers, clinicians, and other experts is essential to unravel the complexities of the gut-lung axis, paving a way for innovative strategies that could transform the management of respiratory diseases.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"39 5","pages":"746-758"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of single-dose evolocumab injection in early-phase acute myocardial infarction: a retrospective single-center study. 单剂量伊夫洛单抗注射液对早期急性心肌梗死的疗效：一项回顾性单中心研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.3904/kjim.2024.080

Yongcheol Kim, Ji Woong Roh, Oh-Hyun Lee, Seok-Jae Heo, Eui Im, Deok-Kyu Cho, Byeong-Keuk Kim

{"title":"Efficacy of single-dose evolocumab injection in early-phase acute myocardial infarction: a retrospective single-center study.","authors":"Yongcheol Kim, Ji Woong Roh, Oh-Hyun Lee, Seok-Jae Heo, Eui Im, Deok-Kyu Cho, Byeong-Keuk Kim","doi":"10.3904/kjim.2024.080","DOIUrl":"10.3904/kjim.2024.080","url":null,"abstract":"Background/aims: Achieving rapid reduction of low-density lipoprotein cholesterol (LDL-C) levels below 55 mg/dL in patients with acute myocardial infarction (AMI) can be challenging with statins alone. This single-center, retrospective study aimed to assess the impact of single-dose injection of evolocumab 140 mg on LDL-C levels during the peri-percutaneous coronary intervention (PCI) period in patients with AMI.Methods: A total of 95 patients with AMI who underwent PCI were divided into the evolocumab (n = 50) and non-evolocumab (n = 45) groups.Results: The percentage change of LDL-C level at 1-3 weeks from baseline was 78.4 ± 13.4% reduction in the evolocumab group versus 45.6 ± 22.6% in the non-evolocumab group, with a mean difference of -33.5% between the groups (95% CI: -42.6 to -24.5%; p < 0.001). The achievement rate of LDL-C levels below 55 mg/dL at 1-3 weeks was significantly higher in the evolocumab group than in the non-evolocumab group (97.7% vs. 60.0%, p < 0.001).Conclusion: Patients with AMI who received single-dose injection of evolocumab 140 mg during the peri-PCI period had a significantly greater LDL-C reduction and higher proportion of patients achieved the target LDL-C level in the early phase AMI than those who did not receive evolocumab.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"793-800"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and chronic kidney disease, an important piece in the puzzle of Cardiovascular-Kidney- Metabolic syndrome. 肥胖症和慢性肾脏病是心血管-儿童-代谢综合征的重要组成部分。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-30 DOI: 10.3904/kjim.2024.273

Young Youl Hyun

引用次数: 0

Drug retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in Korean patients with seropositive rheumatoid arthritis. 韩国血清反应阳性类风湿关节炎患者服用生物制剂和靶向合成改善病情抗风湿药物的药物保留率。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-05-27 DOI: 10.3904/kjim.2023.297

Bong-Woo Lee, Jennifer Jooha Lee, Wan-Uk Kim

{"title":"Drug retention of biologic and targeted synthetic disease-modifying antirheumatic drugs in Korean patients with seropositive rheumatoid arthritis.","authors":"Bong-Woo Lee, Jennifer Jooha Lee, Wan-Uk Kim","doi":"10.3904/kjim.2023.297","DOIUrl":"10.3904/kjim.2023.297","url":null,"abstract":"Background/aims: The aim of this study was to compare the short- and long-term retention rates of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) in Korean patients with seropositive rheumatoid arthritis.Methods: This study was conducted with 1,538 treatment courses of 1,063 patients, including adalimumab (n = 332), etanercept (n = 369), infliximab (n = 146), abatacept (n = 152), tocilizumab (n = 299), tofacitinib (n = 136), and baricitinib (n = 104), in patients with seropositive rheumatoid arthritis who started b/tsDMARD treatment between 2008 and 2020 at Seoul St. Mary's Hospital. Discontinuation 1 and 3 years after the first prescription of each drug was investigated. Kaplan- Meier estimates of time to discontinuation were calculated to compare the difference in drug retention rate for each drug. Patient-level predictors of drug discontinuation were evaluated using a Cox proportional hazards model.Results: The overall 1-year drug retention rate was from 60.1% for adalimumab to 90.0% for tofacitinib in the b/tsDMARD-naïve group, and from 55.2% for infliximab to 84.8% for tofacitinib in the b/tsDMARD-experienced group. The 3-year drug retention rate was from 36.9% for infliximab to 86.5% for tofacitinib in the b/tsDMARD-naïve group, and from 31.0% for infliximab to 65.4% for tocilizumab in the b/tsDMARD-experienced group. Drug discontinuation appeared to be affected by specific types of b/tsDMARDs.Conclusion: Tocilizumab and tofacitinib are less commonly discontinued compared to tumor necrosis factor-α inhibitors at 1 and 3 years. Specifically, tofacitinib in the b/tsDMARD-naïve group and tocilizumab in the b/tsDMARD-experienced group showed the highest 3-year retention rates.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"833-844"},"PeriodicalIF":2.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0