Korean Journal of Internal Medicine最新文献_第4页

Updates on lung cancer screening for early detection. 早期发现肺癌的最新情况。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.008

Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang

{"title":"Updates on lung cancer screening for early detection.","authors":"Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang","doi":"10.3904/kjim.2025.008","DOIUrl":"10.3904/kjim.2025.008","url":null,"abstract":"This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality since its implementation in 2019. This review discusses the LDCT screening in Korea, including reductions in short-term mortality, increased screening uptake, and enhanced smoking cessation rates. Results from major international trials, including the National Lung Screening Trial, Nederlands-Leuvens Longkanker Screenings Onderzoek trial, and Multicenter Italian Lung Detection studies, demonstrating the efficacy of LDCT in reducing lung cancer mortality, are reviewed. The potential of liquid biopsy as a complement to LDCT is explored, with a focus on multi-cancer early detection technologies. Notable advances include the Circulating Cell-free Genome Atlas study and the Galleri® test, which have shown promise in detecting cancer at early stages through blood-based screening. We also highlight the challenges and limitations of current screening methods, including the need to improve strategies for screening non-smokers and the importance of balancing benefits against risks. As lung cancer screening continues to advance, combining LDCT and liquid biopsy is anticipated to provide more comprehensive and effective early detection strategies.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"546-556"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review. 中切断膜在血液透析中的临床益处及未来发展方向综述。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.049

Hyo Jin Kim, Sang Heon Song

{"title":"Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review.","authors":"Hyo Jin Kim, Sang Heon Song","doi":"10.3904/kjim.2025.049","DOIUrl":"10.3904/kjim.2025.049","url":null,"abstract":"Medium cut-off (MCO) membranes have emerged as a promising innovation in hemodialysis (HD), offering enhanced clearance of large middle-molecules of uremic toxins compared to traditional HD membranes, while maintaining minimal loss of albumin. The introduction of MCO membranes represents a significant advancement in dialysis technology, potentially reducing the risk of complications associated with inadequate removal of toxins. Compared to high-flux membranes, MCO membranes demonstrate superior efficacy in eliminating large middle-molecules without excessive loss of beneficial proteins, such as albumin. The clinical benefits of MCO membranes extend beyond toxin clearance. They improve quality of life, reduce erythropoiesis-stimulating agent doses and resistance, lower hospitalization rates, and decrease overall healthcare costs. Currently, there is insufficient evidence regarding the effects of MCO membranes on cardiovascular diseases and mortality. Further studies are required to assess their effects on patient outcomes and long-term survival. Future innovations in membrane technology, coupled with ongoing research and development, have the potential to enhance dialysis efficacy further, reduce complications, and facilitate the development of eco-friendly solutions. Additional studies are required to fully explore the potential of MCO membranes and refine their clinical application.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"557-570"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis. 胃癌发生过程中液体活检样本的不同微生物特征和细胞外囊泡分析的见解。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.339

Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim

{"title":"Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis.","authors":"Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim","doi":"10.3904/kjim.2024.339","DOIUrl":"10.3904/kjim.2024.339","url":null,"abstract":"Background/aims: The early detection of gastric cancer is crucial for improving patient outcomes. However, its pathogenesis is not fully understood. The microbiome and extracellular vesicles (EVs) might play a role in gastric carcinogenesis. We aimed to identify gastric-carcinogenesis-associated microbial signatures and evaluate whether these features vary across disease stages.Methods: We enrolled 141 participants (132 patients with gastric cancer or dysplasia and 9 healthy controls). Microbial-derived EVs were isolated from gastric juice, saliva, serum, and urine. Next-generation sequencing of EV-derived bacterial DNA was performed.Results: This sequencing revealed the alpha and beta diversities and microbial composition across different disease stages. The alpha diversity was significantly increased in the gastric juice and serum of disease groups. The beta diversity showed significant differences among patient groups. Distinct microbial signatures were observed across different disease stages in all four sample types. Specific bacterial species--Cutibacterium acnes, Streptococcus oralis, Pseudomonas antarctica, Ralstonia insidiosa, and Pseudomonas yamanorum--exhibited unique abundance patterns associated with disease progression, suggesting their potential as noninvasive biomarkers.Conclusion: Changes in microbial diversity and distinct microbial signatures were observed during gastric carcinogenesis in both gastric juice and extragastric samples, indicating the potential of microbial-derived EVs from liquid biopsy samples as biomarkers for gastric cancer.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"571-583"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection. COVID-19对间质性肺疾病严重加重和死亡率的临床影响：感染后30天的预后

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.388

Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee

{"title":"Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection.","authors":"Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee","doi":"10.3904/kjim.2024.388","DOIUrl":"10.3904/kjim.2024.388","url":null,"abstract":"Background/aims: The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19.Methods: Using the Korean National Health Insurance claim-based database, we compared the incidence and risk of severe exacerbation and mortality in individuals with ILD who survived at least one month after COVID-19 (COVID-19 cohort, n = 359) and 1:3 age, sex, and body mass index-matched individuals with ILD who did not have COVID-19 (controls, n = 1,077) between October 8, 2020, and August 30, 2021.Results: During a mean follow-up of 7.4 months, the COVID-19 cohort had a higher risk of severe exacerbation compared to controls (aHR 2.26, 95% CI 1.38-3.69). During a mean follow-up of 19.6 months, the COVID-19 cohort had a higher risk of death (aHR 2.79, 95% CI 1.63-4.79) compared to controls. When considering COVID-19 severity, the severe COVID-19 group had a higher risk of severe exacerbation and death compared to controls, while the non-severe COVID-19 group did not show increased risk of severe exacerbation or death. In analyses based on ILD subtype, individuals with idiopathic pulmonary fibrosis in the COVID-19 cohort had the highest risk of severe exacerbation and death.Conclusion: Previous severe COVID-19 was associated with worse clinical outcomes in individuals with ILD, especially in patients with idiopathic pulmonary fibrosis.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"634-644"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of cholesterol gallstones in a Korean population over a 14-year period. 14年来韩国人群中胆固醇胆结石的患病率

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI: 10.3904/kjim.2025.090

Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, Tae Young Park, Jae Hyuk Do, Yoo Shin Choi, Seung Eun Lee, Tae Yoon Lee, Hyun Kang, Hyoung-Chul Oh

{"title":"Prevalence of cholesterol gallstones in a Korean population over a 14-year period.","authors":"Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, Tae Young Park, Jae Hyuk Do, Yoo Shin Choi, Seung Eun Lee, Tae Yoon Lee, Hyun Kang, Hyoung-Chul Oh","doi":"10.3904/kjim.2025.090","DOIUrl":"10.3904/kjim.2025.090","url":null,"abstract":"Background/aims: The incidence of cholesterol gallstones has increased in the last few decades. This study aimed to evaluate the prevalence of cholesterol gallstones in Korea over a 14-year period, analyze any changes, and identify the predisposing factors.Methods: A total of 3,909 patients underwent cholecystectomy for gallstones over the 14-year period and were considered for inclusion in this study. Patients were divided into cholesterol and pigment gallstone groups based on gallstone composition, as determined by Fourier Transform Infrared spectroscopy. Patient characteristics were compared between the two groups.Results: After the exclusion of 259 patients with mixed type gallstones, 3,650 patients were finally included in this study; 2,038 (55.8%) with cholesterol gallstones and 1,612 (44.2%) with pigment gallstones. The proportion of cholesterol gallstones over the 14-year period was 53.8% of the study population as a whole and 77.5% of individuals aged < 50 years. The multivariate analysis revealed that cholesterol gallstones were associated with an age < 50 years, female sex, central obesity, absence of chronic liver diseases, and diabetes mellitus. High density lipoprotein-cholesterol levels showed a tendency toward an association with cholesterol gallstones.Conclusion: The prevalence of cholesterol gallstones in Korea plateaued 53.8% during the 14-year period. However, given the increasing incidence of cholesterol gallstones among younger individuals, the relative prevalence of cholesterol gallstones may increase in the future.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"584-591"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of peripheral leukocyte telomere length with patients with rheumatoid arthritis with a focus on interstitial lung disease. 外周白细胞端粒长度与类风湿关节炎患者间质性肺疾病的关系

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 Epub Date: 2025-04-01 DOI: 10.3904/kjim.2024.148

Young Bin Joo, So-Young Bang, Su Jin Hong, Youkyung Lee, Dongjik Shin, Sang-Cheol Bae, Hye-Soon Lee

{"title":"Association of peripheral leukocyte telomere length with patients with rheumatoid arthritis with a focus on interstitial lung disease.","authors":"Young Bin Joo, So-Young Bang, Su Jin Hong, Youkyung Lee, Dongjik Shin, Sang-Cheol Bae, Hye-Soon Lee","doi":"10.3904/kjim.2024.148","DOIUrl":"10.3904/kjim.2024.148","url":null,"abstract":"Background/aims: This study investigated whether telomere length (TL) in rheumatoid arthritis (RA) patients is shorter than in controls, whether TL in RA patients with interstitial lung disease (RA-ILD) differs from that in those without ILD (RA-nonILD), and whether TL varies according to RA-ILD patterns.Methods: TL was measured in peripheral leukocytes using quantitative polymerase chain reaction. Results were compared between controls (n = 14), RA (n = 70), RA-ILD (n = 53), and RA-nonILD (n = 53), and between the subgroups with usual interstitial pneumonia (UIP; n = 32) and nonspecific interstitial pneumonia (NSIP; n = 8), with age- and sex-matching in each comparison. The correlation between TL and honeycombing extent was determined.Results: RA patients had significantly shorter TL (8.3 ± 2.5 kb) than controls (9.5 ± 0.8 kb; p = 0.002). No significant TL difference was found between RA-ILD and RA-nonILD (8.2 ± 2.8 vs 7.7 ± 2.4 kb, p = 0.271). Among RA-ILD, age (p = 0.011), disease activity (p = 0.018), and UIP (p = 0.038) were significantly associated with shortened TL. TL in UIP was shorter than in NSIP (7.4 ± 1.9 vs. 10.0 ± 3.1 kb, p = 0.026). Honeycombing extent in UIP showed a negative correlation with TL but it was nonsignificant (Rho = -0.131, p = 0.387).Conclusion: This study confirms that RA is associated with shorter TL than in healthy individuals and suggests variations in TL among RA-ILD subtypes, indicating that telomere involvement in pathogenesis may differ by subtype.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"676-686"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and heart failure with preserved ejection fraction: focus on new drugs and future direction in medical treatment. 保留射血分数的肥胖和心力衰竭：关注新药和未来医疗方向。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.3904/kjim.2024.387

Se-Eun Kim, Byung-Su Yoo

引用次数: 0

Fact sheet: nationwide trends in dietary intakes among Korean adults, 2013-2022. 概况介绍：2013-2022 年韩国成年人膳食摄入量的全国性趋势。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.3904/kjim.2024.337

Hannah Oh, Garam Jo, Oh Yoen Kim, Hyunjung Lim, SuJin Song, Jeong-Hwa Choi, Jae Hyun Bae, Eun-Sun Jin, Rockli Kim, Yujin Lee, In-Kyung Jeong, Min-Jeong Shin

{"title":"Fact sheet: nationwide trends in dietary intakes among Korean adults, 2013-2022.","authors":"Hannah Oh, Garam Jo, Oh Yoen Kim, Hyunjung Lim, SuJin Song, Jeong-Hwa Choi, Jae Hyun Bae, Eun-Sun Jin, Rockli Kim, Yujin Lee, In-Kyung Jeong, Min-Jeong Shin","doi":"10.3904/kjim.2024.337","DOIUrl":"10.3904/kjim.2024.337","url":null,"abstract":"Background/aims: Cardiovascular disease is the leading cause of death worldwide. This study aimed to investigate the recent nationwide trends in major dietary risk factors for dyslipidemia and atherosclerosis.Methods: We estimated age-standardized mean intakes of fresh fruits, fresh vegetables, whole grains, dietary fiber, and sugar-sweetened beverages (SSBs); and mean percentage of energy intake from protein, total fat, saturated fat, and polyunsaturated fat using nationally representative samples from the Korean National Health Examination and Nutrition Survey 2013-2022. To assess overall diet quality, we calculated mean Korean Healthy Eating Index (KHEI) (range 0-100, higher scores indicating greater diet quality).Results: In 2013-2022, there were overall decreasing trends in age-standardized mean KHEI score and intakes of fresh fruits and vegetables, whole grains, and dietary fiber; and overall increasing trends in mean intakes of SSBs, protein, and dietary fat among both male and female. The KHEI score increased in older adults aged ≥ 60 years, whereas it decreased among younger adults. Throughout the study period, younger adults tended to have lower intakes of fresh fruits, fresh vegetables, and whole grains; higher intakes of SSBs, protein, and dietary fat; and lower KHEI score. The mean KHEI score was lower in male (vs. female) and lower (vs. higher) income groups.Conclusion: Our data suggest that, from 2013 to 2022, there was a trend toward an unhealthy diet in Korean adults. Our findings also suggest dietary inequalities among age, sex, and income groups, suggesting the need for more intense interventions targeting the vulnerable populations.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"427-437"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymyxin B-hemoperfusion in patients with acute exacerbation of idiopathic pulmonary fibrosis: a single-center prospective pilot study. 特发性肺纤维化急性加重患者的多粘菌素b血灌流：一项单中心前瞻性先导研究

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.3904/kjim.2024.244

Min Jee Kim, Jiyoul Yang, Jin Woo Song

{"title":"Polymyxin B-hemoperfusion in patients with acute exacerbation of idiopathic pulmonary fibrosis: a single-center prospective pilot study.","authors":"Min Jee Kim, Jiyoul Yang, Jin Woo Song","doi":"10.3904/kjim.2024.244","DOIUrl":"10.3904/kjim.2024.244","url":null,"abstract":"Background/aims: Patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) typically have a poor prognosis; however, no effective treatment is available. In recent years, several retrospective studies have suggested the clinical benefits of direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) in patients with AE-IPF. Herein, we aimed to investigate the efficacy and safety of PMX-DHP treatment in patients with AE-IPF.Methods: Patients diagnosed with AE-IPF (n = 10) with a partial pressure of oxygen to fraction of inspiratory oxygen ratio (P/F ratio) > 100 were prospectively enrolled at a single center. PMX-DHP was performed twice for 6 hours (at 24-h intervals) at a flow rate of 80-100 mL/min, and steroid pulse therapy was concurrently administered (500 mg of methylprednisolone for 3 d).Results: The mean patient age was 67 years, and 80.0% were male. During the follow-up (median, 42.5 d; interquartile range, 16.0-174.0 d), seven (70.0%) patients died (including two who underwent transplantation); the in-hospital mortality rate was 70%, while the 30- and 90-day mortality rates were 50.0% and 70.0%, respectively. After 48 hours of PMX-DHP treatment, the P/F ratio improved (mean, 160.0 vs. 229.0; p = 0.054) and C-reactive protein level decreased (mean, 8.3 mg/dL vs. 3.5 mg/dL; p = 0.012). During hospitalization, no PMX-DHP-associated adverse events were observed.Conclusion: Our results suggest that PMX-DHP treatment may be useful at improving oxygenation and reducing inflammation in patients with AE-IPF with acceptable safety profiles, however without affecting their prognosis.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 3","pages":"458-467"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term effects of PCSK-9 inhibitors on percutaneous coronary intervention in patients with acute coronary syndrome. PCSK-9抑制剂对急性冠脉综合征患者经皮冠状动脉介入治疗的短期影响

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.3904/kjim.2024.363

Dong Hyun Gim, In Young Choi, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi

{"title":"Short-term effects of PCSK-9 inhibitors on percutaneous coronary intervention in patients with acute coronary syndrome.","authors":"Dong Hyun Gim, In Young Choi, Young-Jae Ki, Hyun Kuk Kim, Sung Soo Kim, Keun-Ho Park, Heesang Song, Dong-Hyun Choi","doi":"10.3904/kjim.2024.363","DOIUrl":"10.3904/kjim.2024.363","url":null,"abstract":"Background/aims: Proprotein-converting enzyme subtilisin-kexin type 9 (PCSK9) inhibitors act more promptly and efficiently than statins and reduce the risk of cardiovascular events in patients with acute coronary syndrome (ACS). This study aimed to assess the short-term effects of perioperative administration of a single-dose PCSK9 inhibitor in patients with ACS.Methods: This study included 789 consecutive patients undergoing percutaneous coronary intervention (PCI) for ACS. The primary clinical endpoint was the occurrence of major adverse cardiovascular events (MACEs) within one month, including cardiac death, non-fatal myocardial infarction, unanticipated revascularization, stroke, stent thrombosis, and rehospitalization for ischemic causes or heart failure.Results: PCSK9 inhibitors were administered to 201 of 789 patients. MACEs occurred in eight patients (4.0%) in the treated group and 60 patients (10.2%) in the non-treated group for one month (hazard ratio 0.38, 95% confidence interval 0.18 to 0.80, p = 0.010). The benefit of PCSK9 inhibitors in terms of MACEs was greater in the subgroup of patients treated more than 1 hour before PCI than in the subgroup treated less than 1 hour before PCI or treated after PCI and in the non-treated group.Conclusion: In patients undergoing PCI for ACS, the risk of MACEs was lower in those treated with perioperative single-dose PCSK9 inhibitors than in those in the untreated group. This benefit was especially noticeable in the subgroups treated > 1 hour before PCI than in those treated less than 1 hour before PCI or after PCI, regardless of the clinical presentation of ACS.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 3","pages":"438-448"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0