Korean Journal of Internal Medicine最新文献

Association of kidney function and proteinuria with lower-extremity dysfunction in older Korean adults: a cross-sectional study. 韩国老年人肾功能和蛋白尿与下肢功能障碍的关系：一项横断面研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-25 DOI: 10.3904/kjim.2025.088

Bongjo Kim, Eun-Bin Lim, Young Sang Lyu, Minkook Son, Youngmin Yoon

{"title":"Association of kidney function and proteinuria with lower-extremity dysfunction in older Korean adults: a cross-sectional study.","authors":"Bongjo Kim, Eun-Bin Lim, Young Sang Lyu, Minkook Son, Youngmin Yoon","doi":"10.3904/kjim.2025.088","DOIUrl":"https://doi.org/10.3904/kjim.2025.088","url":null,"abstract":"Background/aims: Chronic kidney disease (CKD) is associated with complications that affect physical function and mobility. This study investigated the associations between kidney function, proteinuria, and lower-extremity dysfunction.Methods: Data were obtained from the Korean National Health Insurance Service Health Screening Program, including individuals aged 66 years who participated in the National Screening Program for Transitional Ages in Korea. Participants were stratified based on estimated glomerular filtration rate (eGFR) into four groups: Group 1 (eGFR ≥ 90 mL/min/1.73 m2), Group 2 (60 ≤ eGFR < 90 mL/min/1.73 m2), Group 3 (30 ≤ eGFR < 60 mL/min/1.73 m2), and Group 4 (eGFR < 30 mL/min/1.73 m2). Lower-extremity dysfunction was assessed using two physical tests measuring function and balance. Multivariable logistic regression was performed to examine the associations between kidney function, proteinuria, and lower-extremity dysfunction.Results: Group 2 served as the reference. Both decreased (Groups 3 and 4) and elevated (Group 1) eGFR levels were significantly associated with an increased risk of lower-extremity dysfunction (Group 4: adjusted OR 1.40, 95% CI 1.10-1.78; Group 1: adjusted OR 1.19, 95% CI 1.12-1.25). Similar patterns were observed for balance dysfunction. A U-shaped relationship was identified between eGFR and lower-extremity dysfunction. Proteinuria was independently associated with balance dysfunction (adjusted OR 1.35, 95% CI 1.20-1.51) but not with lower-extremity dysfunction.Conclusions: A U-shaped relationship was identified between renal function and lower-extremity dysfunction, with both lower and elevated eGFR linked to increased risks of impairment, underscoring the need for regular assessment of lower-extremity function and appropriate interventions in patients with CKD, elevated eGFR, or proteinuria.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicted pro-inflammatory high-sensitivity C-reactive protein score and inflammatory bowel disease: a cross-sectional study. 预测促炎高敏c反应蛋白评分与炎症性肠病：一项横断面研究

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-17 DOI: 10.3904/kjim.2025.038

Dong Hyun Kim, Akinkunmi Paul Okekunle, Jioh Kang, Hyun-Soo Kim, Sang Hoon Kim, Min Kyu Jung, Jae Ho Park, Soo Young Na, Hoonjai Chun, Jung Eun Lee, Yun Jeong Lim

{"title":"Predicted pro-inflammatory high-sensitivity C-reactive protein score and inflammatory bowel disease: a cross-sectional study.","authors":"Dong Hyun Kim, Akinkunmi Paul Okekunle, Jioh Kang, Hyun-Soo Kim, Sang Hoon Kim, Min Kyu Jung, Jae Ho Park, Soo Young Na, Hoonjai Chun, Jung Eun Lee, Yun Jeong Lim","doi":"10.3904/kjim.2025.038","DOIUrl":"https://doi.org/10.3904/kjim.2025.038","url":null,"abstract":"Background/aims: The role of pro-inflammatory factors in the pathogenesis of inflammatory bowel diseases (IBD), is not well understood. This study investigated the association between the predicted pro-inflammatory high-sensitivity C-reactive protein (hs-CRP) score and IBD.Methods: This study involved 127 case/non-case pairs matched by age and sex of participants who underwent gastrointestinal endoscopy in Korea. Participants provided comprehensive sociodemographic, lifestyle, and dietary data. We obtained odds ratio (OR) and 95% confidence interval (CI) for IBD prevalence by tertiles of the predicted pro-inflammatory hs-CRP score using multivariable-adjusted logistic regression models at a two-sided p < 0.05.Results: Higher predicted pro-inflammatory hs-CRP score was associated with a higher IBD prevalence; OR (95% CI): 1.00, 0.88 (0.38, 2.07) and 8.11 (2.07, 31.81; p for trend = 0.006). Similar increased trends of IBD prevalence with score increase were observed for men and women. The association was more pronounced for UC prevalence when we separated UC and CD. Compared to the low category, OR (95% CI) were 5.78 (1.29, 25.89) for UC but 1.44 (0.31, 6.69) for CD in the dichotomized higher category. The area under the curve for predicted pro-inflammatory hs-CRP score was 0.72 (95% CI: 0.64, 0.81) for UC and 0.68 (95% CI: 0.58, 0.77) for CD, indicating moderate predictive ability.Conclusions: Higher predicted pro-inflammatory hs-CRP score was significantly associated with an increased prevalence of IBD, particularly UC, and could be a valuable indicator for discriminating people at risk of IBD, offering insights into disease aetiology and opportunities for targeted interventions.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Findings suggestive of fanconi syndrome and multiple myeloma. 提示范可尼综合征和多发性骨髓瘤。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-17 DOI: 10.3904/kjim.2025.004

Hwa-Young Lee, Sung Gyul Lim, Han Sang Lee, Won-Ae Lee, So Mi Kim

引用次数: 0

Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors. 粘膜下生理盐水注射和微型探针内镜超声评估结肠直肠上皮下肿瘤的内镜可切除性。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.384

Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang

{"title":"Submucosal saline injection and mini-probe endoscopic ultrasound to assess endoscopic resectability of colorectal subepithelial tumors.","authors":"Jung-Bin Park, Ji Eun Baek, June Hwa Bae, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Dong-Hoon Yang","doi":"10.3904/kjim.2024.384","DOIUrl":"10.3904/kjim.2024.384","url":null,"abstract":"Background/aims: This study aimed to evaluate the feasibility and outcomes of mini-probe endoscopic ultrasound (mEUS) followed by submucosal saline injection (SSI-mEUS) for assessing the endoscopic resectability of colorectal subepithelial lesions (SELs).Methods: From January 2020 to December 2023, the medical records of 391 SELs (364 patients) were retrospectively reviewed and categorized into no EUS, mEUS-only, and SSI-mEUS groups according to the procedure used. To compare variables between the SSI-mEUS and other groups, the no EUS and mEUS-only groups were combined into the non-SSI-mEUS group. In the SSI-mEUS group, submucosal cushion thickness was endosonographically measured after the saline injection. Treatment outcomes and histological diagnosis were retrospectively reviewed.Results: A total of 210 lesions in the no EUS group, 23 in the mEUS-only group, and 125 in the SSI-mEUS group were endoscopically resected. The mean SEL size was larger in the SSI-mEUS than in the non-SSI-mEUS group (6.8 ± 2.6 mm vs. 4.9 ± 2.6 mm, p < 0.001). R0 resection was achieved in 107 of 110 neoplastic lesions (97.3%) in the SSI-mEUS group vs. 159 of 176 neoplastic lesions (90.3%) in the non-SSI-mEUS group (p = 0.046). Not using SSI-mEUS was the only factor associated with indeterminate or positive deep resection margins (odds ratio 3.45, 95% confidence interval 1.19-13.40, p = 0.021).Conclusion: For colorectal SELs, including those that appear insufficiently elevated during conventional endoscopy, SSI-mEUS enables an objective assessment of the feasibility of endoscopic resection and can predict a high likelihood of achieving a safe and complete resection.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"592-605"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beat-to-beat alternans. Beat-to-beat令。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 Epub Date: 2025-05-21 DOI: 10.3904/kjim.2024.372

Chan-Hee Lee, Melvin M Scheinman

引用次数: 0

Generalized edema with acute renal failure in a patient with diabetes. 糖尿病患者全身性水肿合并急性肾功能衰竭1例。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.428

Yujin Shin, Chang-Hoon Lee, Kyoung Min Kim, Yong Gon Cho, Kyung Pyo Kang

引用次数: 0

Association between body mass index and survival after hematopoietic stem cell transplantation. 造血干细胞移植后体重指数与生存的关系。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.246

Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, Seung-Hwan Lee, Gi June Min, Sung-Soo Park, Silvia Park, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Jae-Ho Yoon

{"title":"Association between body mass index and survival after hematopoietic stem cell transplantation.","authors":"Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, Seung-Hwan Lee, Gi June Min, Sung-Soo Park, Silvia Park, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Jae-Ho Yoon","doi":"10.3904/kjim.2024.246","DOIUrl":"10.3904/kjim.2024.246","url":null,"abstract":"Background/aims: The unclear relationship between body mass index (BMI) and post-hematopoietic stem cell transplantation (HSCT) mortality was investigated, including the impact of metabolic diseases.Methods: This retrospective study conducted at a Korean tertiary hospital (2009-2021) included patients who underwent HSCT. Patients were categorized as underweight (BMI < 18.5 kg/m2, n = 106), normal (BMI 18.5-22.9 kg/m2, n = 1,345), overweight (BMI 23.0-24.9 kg/m2, n = 980), or obese (BMI ≥ 25.0 kg/m2, n = 1,471). Diabetes mellitus (DM), hypertension, and dyslipidemia were identified by disease codes or medication prescriptions. A Cox proportional hazards model was used to analyze mortality risks.Results: Over 108 months, 29.8% (1,164/3,902) of the participants died. Patients with underweight had significantly higher mortality (adjusted HR 1.76, 95% CI 1.29-2.40, p < 0.001) than in those with normal BMI. Patients with overweight and obesity did not show increased mortality. Post-HSCT, DM significantly raised mortality risk (HR 3.36, 95% CI 2.86-3.94, p < 0.001), whereas newly diagnosed dyslipidemia was associated with lower mortality (HR 0.27, 95% CI 0.23-0.33, p < 0.001). Post-transplant hypertension had no significant impact on mortality (HR 1.10, 95% CI 0.95-1.28, p = 0.184).Conclusion: Post-HSCT, obesity is not a prognostic factor for poor survival; however, certain metabolic diseases have diverse effects on mortality.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"645-656"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the immune responses in long COVID through cytokine profiling. 通过细胞因子分析揭示长冠状病毒的免疫反应。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.179

Oh-Hyun Cho

引用次数: 0

Unexplained syncope: what time-to-diagnosis and risk profiles tell us. 不明原因的晕厥：诊断时间和风险概况告诉我们什么。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.180

Yoon Jung Park

引用次数: 0

Updates on lung cancer screening for early detection. 早期发现肺癌的最新情况。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.008

Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang

{"title":"Updates on lung cancer screening for early detection.","authors":"Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang","doi":"10.3904/kjim.2025.008","DOIUrl":"10.3904/kjim.2025.008","url":null,"abstract":"This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality since its implementation in 2019. This review discusses the LDCT screening in Korea, including reductions in short-term mortality, increased screening uptake, and enhanced smoking cessation rates. Results from major international trials, including the National Lung Screening Trial, Nederlands-Leuvens Longkanker Screenings Onderzoek trial, and Multicenter Italian Lung Detection studies, demonstrating the efficacy of LDCT in reducing lung cancer mortality, are reviewed. The potential of liquid biopsy as a complement to LDCT is explored, with a focus on multi-cancer early detection technologies. Notable advances include the Circulating Cell-free Genome Atlas study and the Galleri® test, which have shown promise in detecting cancer at early stages through blood-based screening. We also highlight the challenges and limitations of current screening methods, including the need to improve strategies for screening non-smokers and the importance of balancing benefits against risks. As lung cancer screening continues to advance, combining LDCT and liquid biopsy is anticipated to provide more comprehensive and effective early detection strategies.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"546-556"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0