Korean Journal of Internal Medicine最新文献_第2页

Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease. FoxP3+调节性T细胞频率降低和炎症变化在人急性移植物抗宿主病免疫发病机制中的作用。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.010

Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi

{"title":"Decreased frequency and inflammatory change of FoxP3+ regulatory T cells in immunopathogenesis of human acute graft-versus-host disease.","authors":"Nayeon Seong, Cheongin Yang, Kunye Kwak, Ka-Won Kang, Yong Park, Byung Soo Kim, Seong Hyun Jeong, Joon Seong Park, Yoon Seok Choi","doi":"10.3904/kjim.2025.010","DOIUrl":"10.3904/kjim.2025.010","url":null,"abstract":"Background/aims: Acute graft-versus-host disease (GvHD) is a severe complication of allogeneic stem cell transplantation, characterized by immune-mediated tissue damage primarily affecting the skin, liver, and gastrointestinal tract. Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis. However, the pathogenic roles of changes in Treg cell number and function on acute GvHD remain poorly understood. This study aimed to investigate the quantitative and qualitative changes in Treg cells and their clinical and pathogenic implication of acute GvHD.Methods: A total of 62 patients who underwent allogeneic stem cell transplantation at a tertiary institution from 2019 to 2024 were enrolled. Peripheral blood mononuclear cells were isolated and analyzed by multicolor flow cytometry. Treg cell subsets and cytokine production were assessed after T-cell receptor stimulation. Serum levels of inflammatory cytokines were measured using cytometric bead array, and Treg cell suppressive function was evaluated through co-culture experiments.Results: Patients with acute GvHD showed a decreased frequency of circulating Treg cells, with a notable increase in the CD45RA-FoxP3lo pro-inflammatory subset. Treg cells produced inflammatory cytokines including TNF-α upon stimulation and exhibited reduced suppressive activity. The frequency of TNF-α+ Treg cells correlated with the clinical severity of acute GvHD. Elevated serum levels of IL-6 and IL-21 were associated with the inflammatory conversion of Treg cells.Conclusion: During human acute GvHD, frequencies of circulating Treg cells are significantly decreased. Inflammatory change of Treg cells, represented by TNF-α production and reduced suppressive capacity, contributes to the immunopathogenesis of acute GvHD.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"657-666"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study. 不明原因晕厥中严重心律失常的时间段检出率和预测因素：一项多中心植入式循环记录仪注册研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.364

Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim

{"title":"Detection rate by time period and predictors of serious arrhythmias in unexplained syncope: a multicenter implantable loop recorder registry study.","authors":"Juwon Kim, Il-Young Oh, Myung-Jin Cha, Jinhee Ahn, So-Ryoung Lee, Sung Ho Lee, Jae-Sun Uhm, Pil-Sung Yang, Jaemin Shim, Hyoung-Seob Park, Junbeom Park, Jun Hyung Kim, Ki-Hun Kim, Jumsuk Ko, Hong Euy Lim, Ju Youn Kim","doi":"10.3904/kjim.2024.364","DOIUrl":"10.3904/kjim.2024.364","url":null,"abstract":"Background/aims: Although an implantable loop recorder (ILR) is a valuable tool for investigation of unexplained syncope, there are limited data regarding time course to diagnosis and predictors of serious arrhythmias as a cause of unexplained syncope. We sought to investigate diagnosis rate by time period after ILR implantation and identify predictors of serious arrhythmias in patients with unexplained syncope.Methods: We identified 394 patients who received ILR implantation for unexplained syncope enrolled in the Korean ILR registry.Results: Serious arrhythmias were documented in 205 patients (52.0%). One hundred seventy-two patients (43.7%) had sick sinus-node syndrome (SSS), 24 (6.1%) had atrioventricular block, and nine (2.3%) had ventricular arrhythmia. Of these, 48 (23.4%) and 77 (37.6%) were diagnosed within two weeks and one month after ILR implantation, respectively. Median time to diagnosis was 62 days. In multivariable analysis, left atrial volume index (LAVI) ≥ 34 mL/m2 (hazard ratio [HR] 1.582), hypertension (HR 1.788), sinus bradycardia with a heartrate less than 60 beats per minute (HR 1.762), and LAVI ≥ 34 mL/m2 combined with sinus bradycardia (HR 1.911) were independent predictors of SSS. Cumulative detection rate of SSS was significantly higher in patients with LAVI ≥ 34 mL/m2 than those with LAVI < 34 mL/m2 (p < 0.001).Conclusion: More than half of patients with unexplained syncope had serious arrhythmias, and more than one-third of these arrhythmias were diagnosed within one month after ILR implantation. LAVI combined with sinus bradycardia may be a useful predictor of SSS as a cause of unexplained syncope.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"616-625"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer. 一线阿法替尼治疗高龄晚期egfr突变非小细胞肺癌的疗效和安全性

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.269

Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Min Ki Lee, Insu Kim, Kyung Soo Hong, June Hong Ahn, Jung Seop Eom

{"title":"Efficacy and safety of first-line afatinib in older patients with advanced EGFR-mutated non-small cell lung cancer.","authors":"Mi-Hyun Kim, Hayoung Seong, Soo Han Kim, Min Ki Lee, Insu Kim, Kyung Soo Hong, June Hong Ahn, Jung Seop Eom","doi":"10.3904/kjim.2024.269","DOIUrl":"10.3904/kjim.2024.269","url":null,"abstract":"Background/aims: This study investigated the efficacy and safety of first-line afatinib treatment in older patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).Methods: This retrospective, multicenter, observational cohort study included 103 patients aged ≥ 75 years who were treated with first-line afatinib for EGFR-mutated NSCLC. The primary outcome was time-on-treatment (TOT).Results: The median TOT of patients was 13.6 months (95% confidence interval 11.0-16.2). Ninety-two patients (89.3%) required dose modification. Dose reduction was significantly more frequent in the 40 mg starting dose group than in the 30 mg group (93.1% vs. 68.8%, p = 0.004). The most common grade 3 or worse adverse events (AEs) were diarrhea (n = 16, 54%), acneiform rash (n = 4, 14.3%), and stomatitis (n = 4, 14.3%). Grade 3 or worse AEs led to dose modification in 23 of 28 patients (82.1%) and permanent discontinuation of therapy in five of 28 patients (17.9%). On disease progression, tissue re-biopsy was performed in 18 of 74 patients (24.3%). Thirty-four patients (45.9%) received subsequent chemotherapy; of these, most patients (n = 21, 61.8%) received pemetrexed monotherapy.Conclusion: This study demonstrated the efficacy of first-line afatinib treatment for EGFR-mutant NSCLC in older patients. However, despite similar safety profiles and frequencies of AEs reported in previous studies, the frequency of dose modifications was higher in this population. A 30 mg starting dose of afatinib and a predefined dose adjustment may be suitable strategies for this population. Post-tyrosine kinase inhibitor management, such as tissue re-biopsy and platinum-based chemotherapy, tended to be underprescribed in this age group.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"626-633"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the immune responses in long COVID through cytokine profiling. 通过细胞因子分析揭示长冠状病毒的免疫反应。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.179

Oh-Hyun Cho

引用次数: 0

Unexplained syncope: what time-to-diagnosis and risk profiles tell us. 不明原因的晕厥：诊断时间和风险概况告诉我们什么。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.180

Yoon Jung Park

引用次数: 0

Updates on lung cancer screening for early detection. 早期发现肺癌的最新情况。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.008

Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang

{"title":"Updates on lung cancer screening for early detection.","authors":"Se Hyun Kwak, Chi Young Kim, Sang Hoon Lee, Eun Young Kim, Eun Hye Lee, Yoon Soo Chang","doi":"10.3904/kjim.2025.008","DOIUrl":"10.3904/kjim.2025.008","url":null,"abstract":"This review examines the current status and recent progress in lung cancer screening programs, focusing on low-dose computed tomography (LDCT) and emerging liquid biopsy technologies. In Korea, the National Lung Cancer Screening Program has shown promising results in reducing lung cancer mortality since its implementation in 2019. This review discusses the LDCT screening in Korea, including reductions in short-term mortality, increased screening uptake, and enhanced smoking cessation rates. Results from major international trials, including the National Lung Screening Trial, Nederlands-Leuvens Longkanker Screenings Onderzoek trial, and Multicenter Italian Lung Detection studies, demonstrating the efficacy of LDCT in reducing lung cancer mortality, are reviewed. The potential of liquid biopsy as a complement to LDCT is explored, with a focus on multi-cancer early detection technologies. Notable advances include the Circulating Cell-free Genome Atlas study and the Galleri® test, which have shown promise in detecting cancer at early stages through blood-based screening. We also highlight the challenges and limitations of current screening methods, including the need to improve strategies for screening non-smokers and the importance of balancing benefits against risks. As lung cancer screening continues to advance, combining LDCT and liquid biopsy is anticipated to provide more comprehensive and effective early detection strategies.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"546-556"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review. 中切断膜在血液透析中的临床益处及未来发展方向综述。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2025.049

Hyo Jin Kim, Sang Heon Song

{"title":"Clinical benefits and future directions of medium cut-off membranes in hemodialysis: a comprehensive review.","authors":"Hyo Jin Kim, Sang Heon Song","doi":"10.3904/kjim.2025.049","DOIUrl":"10.3904/kjim.2025.049","url":null,"abstract":"Medium cut-off (MCO) membranes have emerged as a promising innovation in hemodialysis (HD), offering enhanced clearance of large middle-molecules of uremic toxins compared to traditional HD membranes, while maintaining minimal loss of albumin. The introduction of MCO membranes represents a significant advancement in dialysis technology, potentially reducing the risk of complications associated with inadequate removal of toxins. Compared to high-flux membranes, MCO membranes demonstrate superior efficacy in eliminating large middle-molecules without excessive loss of beneficial proteins, such as albumin. The clinical benefits of MCO membranes extend beyond toxin clearance. They improve quality of life, reduce erythropoiesis-stimulating agent doses and resistance, lower hospitalization rates, and decrease overall healthcare costs. Currently, there is insufficient evidence regarding the effects of MCO membranes on cardiovascular diseases and mortality. Further studies are required to assess their effects on patient outcomes and long-term survival. Future innovations in membrane technology, coupled with ongoing research and development, have the potential to enhance dialysis efficacy further, reduce complications, and facilitate the development of eco-friendly solutions. Additional studies are required to fully explore the potential of MCO membranes and refine their clinical application.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"557-570"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis. 胃癌发生过程中液体活检样本的不同微生物特征和细胞外囊泡分析的见解。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.339

Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim

{"title":"Distinct microbial signatures of liquid biopsy samples during gastric carcinogenesis and insights from extracellular vesicle analysis.","authors":"Hee Sang You, Jae Yong Park, Hochan Seo, Beom Jin Kim, Jae Gyu Kim","doi":"10.3904/kjim.2024.339","DOIUrl":"10.3904/kjim.2024.339","url":null,"abstract":"Background/aims: The early detection of gastric cancer is crucial for improving patient outcomes. However, its pathogenesis is not fully understood. The microbiome and extracellular vesicles (EVs) might play a role in gastric carcinogenesis. We aimed to identify gastric-carcinogenesis-associated microbial signatures and evaluate whether these features vary across disease stages.Methods: We enrolled 141 participants (132 patients with gastric cancer or dysplasia and 9 healthy controls). Microbial-derived EVs were isolated from gastric juice, saliva, serum, and urine. Next-generation sequencing of EV-derived bacterial DNA was performed.Results: This sequencing revealed the alpha and beta diversities and microbial composition across different disease stages. The alpha diversity was significantly increased in the gastric juice and serum of disease groups. The beta diversity showed significant differences among patient groups. Distinct microbial signatures were observed across different disease stages in all four sample types. Specific bacterial species--Cutibacterium acnes, Streptococcus oralis, Pseudomonas antarctica, Ralstonia insidiosa, and Pseudomonas yamanorum--exhibited unique abundance patterns associated with disease progression, suggesting their potential as noninvasive biomarkers.Conclusion: Changes in microbial diversity and distinct microbial signatures were observed during gastric carcinogenesis in both gastric juice and extragastric samples, indicating the potential of microbial-derived EVs from liquid biopsy samples as biomarkers for gastric cancer.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"571-583"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of cholesterol gallstones in a Korean population over a 14-year period. 14年来韩国人群中胆固醇胆结石的患病率

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI: 10.3904/kjim.2025.090

Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, Tae Young Park, Jae Hyuk Do, Yoo Shin Choi, Seung Eun Lee, Tae Yoon Lee, Hyun Kang, Hyoung-Chul Oh

{"title":"Prevalence of cholesterol gallstones in a Korean population over a 14-year period.","authors":"Gyumin Lee, Jeong Yoon Suh, Junyeol Kim, Tae Young Park, Jae Hyuk Do, Yoo Shin Choi, Seung Eun Lee, Tae Yoon Lee, Hyun Kang, Hyoung-Chul Oh","doi":"10.3904/kjim.2025.090","DOIUrl":"10.3904/kjim.2025.090","url":null,"abstract":"Background/aims: The incidence of cholesterol gallstones has increased in the last few decades. This study aimed to evaluate the prevalence of cholesterol gallstones in Korea over a 14-year period, analyze any changes, and identify the predisposing factors.Methods: A total of 3,909 patients underwent cholecystectomy for gallstones over the 14-year period and were considered for inclusion in this study. Patients were divided into cholesterol and pigment gallstone groups based on gallstone composition, as determined by Fourier Transform Infrared spectroscopy. Patient characteristics were compared between the two groups.Results: After the exclusion of 259 patients with mixed type gallstones, 3,650 patients were finally included in this study; 2,038 (55.8%) with cholesterol gallstones and 1,612 (44.2%) with pigment gallstones. The proportion of cholesterol gallstones over the 14-year period was 53.8% of the study population as a whole and 77.5% of individuals aged < 50 years. The multivariate analysis revealed that cholesterol gallstones were associated with an age < 50 years, female sex, central obesity, absence of chronic liver diseases, and diabetes mellitus. High density lipoprotein-cholesterol levels showed a tendency toward an association with cholesterol gallstones.Conclusion: The prevalence of cholesterol gallstones in Korea plateaued 53.8% during the 14-year period. However, given the increasing incidence of cholesterol gallstones among younger individuals, the relative prevalence of cholesterol gallstones may increase in the future.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"584-591"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection. COVID-19对间质性肺疾病严重加重和死亡率的临床影响：感染后30天的预后

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2025-07-01 DOI: 10.3904/kjim.2024.388

Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee

{"title":"Clinical impacts of COVID-19 on severe exacerbation and mortality in interstitial lung disease: prognosis 30 days after infection.","authors":"Bo-Guen Kim, Sun-Kyung Lee, Dong Won Park, Tai Sun Park, Ji-Yong Moon, Tae-Hyung Kim, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee","doi":"10.3904/kjim.2024.388","DOIUrl":"10.3904/kjim.2024.388","url":null,"abstract":"Background/aims: The impact of coronavirus disease 2019 (COVID-19) on severe exacerbation and mortality in interstitial lung disease (ILD) is unclear. In this study, we evaluate the risk of severe exacerbation and mortality in individuals with ILD following COVID-19.Methods: Using the Korean National Health Insurance claim-based database, we compared the incidence and risk of severe exacerbation and mortality in individuals with ILD who survived at least one month after COVID-19 (COVID-19 cohort, n = 359) and 1:3 age, sex, and body mass index-matched individuals with ILD who did not have COVID-19 (controls, n = 1,077) between October 8, 2020, and August 30, 2021.Results: During a mean follow-up of 7.4 months, the COVID-19 cohort had a higher risk of severe exacerbation compared to controls (aHR 2.26, 95% CI 1.38-3.69). During a mean follow-up of 19.6 months, the COVID-19 cohort had a higher risk of death (aHR 2.79, 95% CI 1.63-4.79) compared to controls. When considering COVID-19 severity, the severe COVID-19 group had a higher risk of severe exacerbation and death compared to controls, while the non-severe COVID-19 group did not show increased risk of severe exacerbation or death. In analyses based on ILD subtype, individuals with idiopathic pulmonary fibrosis in the COVID-19 cohort had the highest risk of severe exacerbation and death.Conclusion: Previous severe COVID-19 was associated with worse clinical outcomes in individuals with ILD, especially in patients with idiopathic pulmonary fibrosis.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"40 4","pages":"634-644"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0