Korean Journal of Internal Medicine最新文献_第2页

Impact of COVID-19 on end-stage kidney disease incidence and clinical practice. COVID-19 对终末期肾病发病率和临床实践的影响。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 DOI: 10.3904/kjim.2024.350

Hayne Cho Park, Young-Ki Lee

引用次数: 0

A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study. 老年人全身低度炎症与虚弱之间的联系：一项全国性人群研究的临床证据。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.3904/kjim.2024.050

Min-Gu Kang, Hee-Won Jung, Beom-Jun Kim

{"title":"A link between systemic low-grade inflammation and frailty in older adults: clinical evidence from a nationwide population-based study.","authors":"Min-Gu Kang, Hee-Won Jung, Beom-Jun Kim","doi":"10.3904/kjim.2024.050","DOIUrl":"10.3904/kjim.2024.050","url":null,"abstract":"Background/aims: Despite the possible role of systemic low-grade inflammation on frailty, the majority of previous studies have focused solely on the phenotypic frailty with limited participant numbers, thereby weakening the evidence supporting the notion that circulating C-reactive protein (CRP) could be a potential frailty biomarker.Methods: This study is a nationally representative, population-based, cross-sectional analysis from the Korea National Health and Nutrition Examination Survey, involving 5,359 participants aged 65 and older. We generated a deficit accumulation frailty index (FI) based on 38 items, encompassing physical, cognitive, psychological, and social status. Frailty was classified as non-frail (FI ≤ 0.15), pre-frail (0.15 < FI ≤ 0.25), or frail (FI > 0.25). Serum high-sensitivity CRP (hsCRP) levels were measured by immunoturbidometric method.Results: After adjusting for confounders including age, sex, income, education, smoking, hypertension, diabetes, dyslipidemia, stroke, cardiovascular diseases, and body mass index, serum hsCRP levels were 29.4% higher in frail participants compared to their non-frail counterparts (p = 0.001). Additionally, circulating hsCRP concentrations positively correlated with the FI (p = 0.003), and the odds ratio for frailty per standard deviation increase in serum hsCRP was 1.18 (p = 0.001). Moreover, older adults in the highest hsCRP quartile exhibited a significant higher FI with a 1.59-fold increased odds ratio for frailty than those in the lowest quartile (p = 0.002 and 0.001, respectively).Conclusion: These findings validate the impact of age-related systemic low-grade inflammation on frailty and support the utility of serum hsCRP as a potential biomarker for detecting frailty in older adults.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"1011-1020"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of PD-1/PD-L1 pathway in ulcerative colitis and changes following tonsil-derived mesenchymal stem cells treatment. PD-1/PD-L1通路在溃疡性结肠炎中的作用及扁桃体间充质干细胞治疗后的变化。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 DOI: 10.3904/kjim.2024.019

Eun Mi Song, Yang Hee Joo, Sung-Ae Jung, Ju-Ran Byeon, A-Reum Choe, Yehyun Park, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim

{"title":"The role of PD-1/PD-L1 pathway in ulcerative colitis and changes following tonsil-derived mesenchymal stem cells treatment.","authors":"Eun Mi Song, Yang Hee Joo, Sung-Ae Jung, Ju-Ran Byeon, A-Reum Choe, Yehyun Park, Chung Hyun Tae, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Ki-Nam Shim","doi":"10.3904/kjim.2024.019","DOIUrl":"10.3904/kjim.2024.019","url":null,"abstract":"Background/aims: The programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway has not been fully evaluated in inflammatory bowel disease. We evaluated PD-1/PD-L1 levels in patients with ulcerative colitis (UC) and their significance in tonsil-derived mesenchymal stem cells (TMSCs) treatment.Methods: Using acute and chronic murine colitis model, we measured the PD-1 and PD-L1 levels in inflamed colonic tissues pre- and post-treatment with TMSCs. We also measured PD-1 and PD-L1 levels in colonic tissues from UC patients, compared to normal controls.Results: In the analysis using human colonic tissues, a significant increase in the levels of PD-1 and PD-L1 was observed in the colonic mucosa of patients with UC compared with normal controls (p < 0.001 and p = 0.005, respectively). When comparing the maximal disease extent, PD-L1 levels were highest in patients with proctitis (38.5 ± 46.7), followed by left-side colitis (17.5 ± 23.1) and extensive colitis (5.2 ± 8.2) (p < 0.001). In the chronic colitis model, the level of PD-L1 was decreased (p = 0.040) and the level of PD-1 increased more than in normal controls (p = 0.047). After treatment with TMSC, significant improvements were observed in body weight, disease activity index, and colon length recovery. Additionally, the levels of PD-1 and PD-L1 were recovered; PD-L1 significantly increased (p = 0.031), while the level of PD-1 decreased (p = 0.310).Conclusion: The altered expression of PD-1 and PD-L1 in colonic mucosa may be a possible mechanism of UC, and T-MSC-derived PD-L1 could help suppress colitis.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"39 6","pages":"917-930"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between oral health and hyperuricemia in Korean adults: Korea National Health and Nutrition Examination Survey 2016-2019. 韩国成年人口腔健康与高尿酸血症之间的关系：2016-2019年韩国国民健康与营养调查》。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.3904/kjim.2023.425

Junyong Park, Minkook Son, Sung Won Lee, Won Tae Chung, Sang Yeob Lee

{"title":"Association between oral health and hyperuricemia in Korean adults: Korea National Health and Nutrition Examination Survey 2016-2019.","authors":"Junyong Park, Minkook Son, Sung Won Lee, Won Tae Chung, Sang Yeob Lee","doi":"10.3904/kjim.2023.425","DOIUrl":"10.3904/kjim.2023.425","url":null,"abstract":"Background/aims: Hyperuricemia plays an essential role in the gout. Despite the clinical significance of hyperuricemia, a direct relationship between oral health and hyperuricemia has not been established. We aim to investigate the association between oral health and hyperuricemia.Methods: We selected 17,557 subjects from the Korea National Health and Nutrition Examination Survey database for the years 2016-2019. Oral health-related variables included the number of dental caries, regular tooth brushing, use of secondary oral products, and regular dental examinations. The odds ratio (OR) and 95% confidence intervals (CIs) for hyperuricemia were calculated using a multivariable-adjusted logistic regression model.Results: Oral health status with dental caries and oral health behaviors, including tooth brushing, secondary oral products, and regular dental examination, were significantly associated with hyperuricemia in all participants. The adjusted OR and 95% CIs for hyperuricemia comparing more than three dental caries with no dental caries were 1.28 (1.08-1.52). The adjusted OR and 95% CIs for hyperuricemia in regular tooth brushing, use of secondary oral products, and regular dental examination were 0.78 (0.67-0.91), 0.91 (0.83-1.00), and 0.86 (0.78-0.95), respectively. Notably, the association between oral health and hyperuricemia was more prominent in male subjects. In addition, when subjects were grouped by the oral health scoring system, the prevalence of hyperuricemia was lower in groups with better oral health scores.Conclusion: We demonstrated that oral health status and behaviors are associated with hyperuricemia, particularly in males. Further studies are necessary to confirm the association between oral health and hyperuricemia.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"1001-1010"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity. 肠易激综合征中紧密连接蛋白的变化：年龄与疾病严重程度的关系。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 DOI: 10.3904/kjim.2024.097

Sang Un Kim, Ji A Choi, Man-Hoon Han, Jin Young Choi, Ji Hye Park, Moon Sik Kim, Yong Hwan Kwon

{"title":"Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity.","authors":"Sang Un Kim, Ji A Choi, Man-Hoon Han, Jin Young Choi, Ji Hye Park, Moon Sik Kim, Yong Hwan Kwon","doi":"10.3904/kjim.2024.097","DOIUrl":"10.3904/kjim.2024.097","url":null,"abstract":"Background/aims: The etiology of irritable bowel syndrome (IBS) is associated with intestinal mucosal barrier damage. However, changes in the tight junction (TJ) proteins in IBS have not been fully elucidated. This study aimed to evaluate TJ protein changes in IBS patients and the relationship between aging and disease severity.Methods: Thirty-six patients with IBS fulfilling the Rome IV criteria and twenty-four controls were included. To evaluate the change of TJ in the colonic mucosa, quantitative reverse transcription polymerase chain reaction, western blot, and immunohistochemistry (IHC) were performed, respectively.Results: The entire IBS group (n = 36) exhibited decreased levels of claudin-1 and -2 mRNA compared to the control group (n = 24), with statistical significance (p < 0.05). Additionally, in western blot analyses, both claudin-1 and ZO-1 levels were significantly reduced in the IBS group compared to the control group (n = 24) (p < 0.05). IHC analysis further revealed that ZO-1 expression was significantly lower in the IBS group than in the control group (p < 0.001). This trend of reduced ZO-1 expression was also observed in the moderate-to-severe IBS subgroup (p < 0.001). Significantly, ZO-1 expression was notably lower in both the young- (p = 0.036) and old-aged (p = 0.039) IBS groups compared to their respective age-matched control groups. Subtype analysis indicated a more pronounced decrease in ZO-1 expression with advancing age.Conclusion: ZO-1 expression was especially decreased in the aged IBS group. These results suggest that ZO-1 might be the prominent TJ protein causing IBS in the aging population.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":"39 6","pages":"906-916"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning approaches toward an understanding of acute kidney injury: current trends and future directions. 了解急性肾损伤的机器学习方法：当前趋势和未来方向。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-29 DOI: 10.3904/kjim.2024.098

Inyong Jeong, Nam-Jun Cho, Se-Jin Ahn, Hwamin Lee, Hyo-Wook Gil

{"title":"Machine learning approaches toward an understanding of acute kidney injury: current trends and future directions.","authors":"Inyong Jeong, Nam-Jun Cho, Se-Jin Ahn, Hwamin Lee, Hyo-Wook Gil","doi":"10.3904/kjim.2024.098","DOIUrl":"10.3904/kjim.2024.098","url":null,"abstract":"Acute kidney injury (AKI) is a significant health challenge associated with adverse patient outcomes and substantial economic burdens. Many authors have sought to prevent and predict AKI. Here, we comprehensively review recent advances in the use of artificial intelligence (AI) to predict AKI, and the associated challenges. Although AI may detect AKI early and predict prognosis, integration of AI-based systems into clinical practice remains challenging. It is difficult to identify AKI patients using retrospective data; information preprocessing and the limitations of existing models pose problems. It is essential to embrace standardized labeling criteria and to form international multi-institutional collaborations that foster high-quality data collection. Additionally, existing constraints on the deployment of evolving AI technologies in real-world healthcare settings and enhancement of the reliabilities of AI outputs are crucial. Such efforts will improve the clinical applicability, performance, and reliability of AKI Clinical Support Systems, ultimately enhancing patient prognoses.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"882-897"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of discharge checklist on guideline-directed medical therapy and mid-term prognosis in heart failure. 出院清单对指导性医疗治疗和心力衰竭中期预后的影响。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-11-01 Epub Date: 2024-10-24 DOI: 10.3904/kjim.2024.088

Won-Seok Lee, Kyu-Sun Lee, Helsi Rismiati, Hae-Young Lee

{"title":"Impact of discharge checklist on guideline-directed medical therapy and mid-term prognosis in heart failure.","authors":"Won-Seok Lee, Kyu-Sun Lee, Helsi Rismiati, Hae-Young Lee","doi":"10.3904/kjim.2024.088","DOIUrl":"10.3904/kjim.2024.088","url":null,"abstract":"Background/aims: Despite the proven benefit of the guideline-directed medical therapy (GDMT), it remains underutilized in patients hospitalized with acute heart failure (HF). We aimed to evaluate the impact of the discharge checklist on GDMT installation and the prognosis of HF patients.Methods: This study was a single-center, observational study that included all patients admitted for HF from March 2021 to February 2023. The data were retrieved from electronic medical records and discharge checklists. A comparison was conducted between the checklist group and the non-checklist group. The primary endpoint was a composite of all-cause mortality or readmission for HF within 6 months.Results: The checklist was completed for 537 patients (checklist group) and not for 187 patients (non-checklist group). The proportion of patients to whom two or more components of GDMT were prescribed was significantly higher in the checklist group than in the non-checklist group (59.6% vs 42.2%, p < 0.001). The checklist group exhibited a significantly lower primary outcome compared to the non-checklist group (27.4% vs. 36.4%, HR 0.73, 95% CI 0.55-0.98, p = 0.036). The effect of the checklist was more prominent in HF with reduced ejection fraction (HR 0.51, 95% CI 0.34-0.77, p = 0.001) than in HF with mildly-reduced and preserved ejection fraction (HR 0.91, 95% CI 0.58-1.42, p = 0.676) (p for interaction = 0.06).Conclusion: The implementation of the discharge checklist was associated with an improvement in GDMT prescription and an improved prognosis in patients with HF with reduced ejection fraction.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":"945-956"},"PeriodicalIF":2.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer. 多模态超声诊断甲状腺乳头状癌宫颈转移淋巴结的费舍尔判别分析

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-10-29 DOI: 10.3904/kjim.2024.122

Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang

{"title":"Fisher discriminant analysis of multimodal ultrasound in diagnosis of cervical metastatic lymph nodes in papillary thyroid cancer.","authors":"Yixuan Wang, Yue Han, Fei Li, Yuyang Lin, Bei Wang","doi":"10.3904/kjim.2024.122","DOIUrl":"https://doi.org/10.3904/kjim.2024.122","url":null,"abstract":"Background/aims: The purpose of this study was to develop a diagnostic model utilizing multimodal ultrasound parameters to aid in the detection of cervical lymph node metastasis in papillary thyroid cancer (PTC) patients.Methods: The study included 84 suspicious lymph nodes from 69 PTC patients, all of whom underwent fine needle aspiration with pathological results. Data from conventional grayscale ultrasound, shear wave elastography (SWE), and superb microvascular imaging were analyzed. Key ultrasound features were compared between benign and metastatic groups to create a diagnostic model using Fisher's stepwise discriminant analysis. The model's effectiveness was assessed with self-testing, cross-validation, and receiver operating characteristic curve analysis.Results: Four features, namely lymphatic hilum (X1), cortical hyperechogenicity (X2), vascular pattern (X4), and SWEmean (X7), were integral to the discriminant analysis, resulting in the equation: Y1 = -3.461 + 2.423X1 + 0.321X2 + 1.620X4 + 0.109X7, Y2 = -8.053 + 0.414X1 + 2.600X2 + 2.504X4 + 0.192X7. If Y1 < Y2, the LN would be diagnosed as metastatic lymph nodes. The model demonstrated an area under the curve of 0.833, with a sensitivity of 83.33% and specificity of 83.33%.Conclusions: The multimodal ultrasound diagnostic model, established through Fisher's stepwise discriminant analysis, proved effective in identifying metastatic lymph nodes in PTC patients.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study. 原发性斯约格伦综合征患者间质性肺病的长期预后：一项回顾性观察研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-10-25 DOI: 10.3904/kjim.2023.402

Jung Hee Koh, Youngjae Park, Jennifer Lee, Howook Jeon, Su-Jin Moon, Yong Hyun Kim, Jun-Ki Min, Sung-Hwan Park, Seung-Ki Kwok

{"title":"Long-term outcome of interstitial lung disease in patients with primary Sjögren's syndrome: a retrospective observational study.","authors":"Jung Hee Koh, Youngjae Park, Jennifer Lee, Howook Jeon, Su-Jin Moon, Yong Hyun Kim, Jun-Ki Min, Sung-Hwan Park, Seung-Ki Kwok","doi":"10.3904/kjim.2023.402","DOIUrl":"https://doi.org/10.3904/kjim.2023.402","url":null,"abstract":"Background/aims: Interstitial lung disease (ILD) is a potentially serious but underdiagnosed manifestation of primary Sjögren's syndrome (pSS). This observational study investigated the prevalence and clinical course of ILD in pSS, together with prognostic factors.Methods: A multicenter, retrospective longitudinal study was performed using findings from baseline and follow-up pulmonary function tests and chest computed tomography. Predisposing factors for the development of ILD and acute exacerbation (AE) were identified using a logistic regression model. The risk factors for a significant decline of pulmonary function were determined by the Cox proportional hazard model.Results: A total of 1,306 patients with pSS were included in this study (female, 98%; mean age, 54 years). Among them, 79 patients with pSS were comorbid with ILD. ILD was more frequently found in male, older patients. Nonspecific interstitial pneumonia was the most prevalent imaging pattern in pSS-ILD (51%), followed by usual interstitial pneumonia (22%). At diagnosis with pSS-ILD, 54% of patients had restrictive pulmonary function, and 41% of patients initiated pharmacological treatment. During the median 4-year follow-up period, AE, a significant decline in pulmonary function, and death occurred in 19%, 29%, and 9% of patients with pSS-ILD, respectively. The neutrophil-to-lymphocyte ratio (NLR) increased 3 months prior to AE, and it was associated with AE. Older age at pSS-ILD diagnosis was a prognostic factor for a significant decline in pulmonary function.Conclusions: ILD accounted for 6% of the comorbidity of pSS. AE was associated with a significant decline in pulmonary function, and the NLR may predict AE.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty liver index and development of lung cancer: a nationwide cohort study. 脂肪肝指数与肺癌发病：一项全国性队列研究。

IF 2.2 4区医学

Korean Journal of Internal Medicine Pub Date : 2024-10-22 DOI: 10.3904/kjim.2024.232

Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim

{"title":"Fatty liver index and development of lung cancer: a nationwide cohort study.","authors":"Jihye Lim, Bongseong Kim, Kyungdo Han, Jeong Uk Lim","doi":"10.3904/kjim.2024.232","DOIUrl":"https://doi.org/10.3904/kjim.2024.232","url":null,"abstract":"Background/aims: This study aimed to evaluate the impact of steatotic liver disease severity on the cumulative incidence of lung cancer utilizing data from the Korea National Health Insurance Service (NHIS).Methods: This study examined the risk of lung cancer in the general population in conjunction with the incidence of steatotic liver disease. The study population consisted of 3,261,438 individuals aged 20 years or older who underwent a general health examination in 2009.Results: Individuals with fatty liver index (FLI) of 30-59 exhibited a 1.08-fold increased risk of lung cancer (95% CI: 1.04-1.11), while FLI ≥ 60 was associated with a 1.22-fold elevated risk of lung cancer (95% CI: 1.17-1.28) compared to those with FLI < 30. The risk varied with smoking status; in current smokers, the adjusted HR for the FLI 30-59 group was 1.05 (95% CI: 1.00-1.10), while that in the FLI ≥ 60 group was 1.11 (95% CI: 1.04-1.18). In never- or past-smokers, the adjusted HR for the FLI 30-59 group was 1.10, and that for the FLI ≥ 60 group was 1.31. Subgroup analysis revealed an incidence rate of 1.06 per 1,000 person-years in the consistently high FLI group compared to 1.15 in those with improved FLI. Improving FLI over time was associated with a 0.93-fold decrease in lung cancer risk.Conclusions: Our study demonstrated a correlational relationship between lung cancer incidence and the severity of steatotic liver disease as measured by FLI.","PeriodicalId":48785,"journal":{"name":"Korean Journal of Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142478330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0