Malaysian Journal of Pathology最新文献_第3页

Genetic architecture of Multiple Myeloma and its prognostic implications - An updated review. 多发性骨髓瘤的遗传结构及其预后意义-最新综述。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

E Foong, R Ankathil

{"title":"Genetic architecture of Multiple Myeloma and its prognostic implications - An updated review.","authors":"E Foong, R Ankathil","doi":"","DOIUrl":"","url":null,"abstract":"Multiple myeloma (MM), a clonal B-cell neoplasia, is an incurable and heterogeneous disease where survival ranges from a few months to more than 10 years. The clinical heterogeneity of MM arises from multiple genomic events that result in tumour development and progression. Recurring genomic abnormalities including cytogenetic abnormalities, gene mutations and abnormal gene expression profiles in myeloma cells have a strong prognostic power. With the advancement in technologies and the development of novel drugs, the prognostic factors and treatment paradigms of MM have been fast evolving over the past few years. Following the introduction of new highthroughput cytogenomic technologies such as array comparative genome hybridisation (aCGH) or single nucleotide polymorphism array (SNP array) and molecular techniques such as gene expression profiling (GEP) and massively parallel genomic sequencing, the prediction of survival in MM no longer solely depends on conventional cytogenetics and interphase fluorescence in situ hybridisation (iFISH) analysis findings. These new technologies enable screening for all possible chromosomal aberrations and other genomic alterations, identifying each aberration on a case-bycase basis and discovering new aberrations that are relevant in unraveling the tumor cells' complex biology. This in turn allows a better understanding of the disease complexity and heterogeneity. The objective of this review on the genetic architecture of MM is to discuss the latest developments on the cytogenetic/cytogenomic-based risk classification of MM that are currently in use and their prognostic implications.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"379-393"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MACB CKD Task Force updated recommendations for reporting estimated glomerular filtration rate and albuminuria in adults. MACB CKD工作组更新了报告成人肾小球滤过率和蛋白尿的建议。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

P Sthaneshwar, L C Lai, S C Thambiah, S K Lim, A Zulkely, L Y Lee, N M Noor, P H Chuo, S Ishak, S S Anas, S S A Soheimi, R E R Aziddin

{"title":"MACB CKD Task Force updated recommendations for reporting estimated glomerular filtration rate and albuminuria in adults.","authors":"P Sthaneshwar, L C Lai, S C Thambiah, S K Lim, A Zulkely, L Y Lee, N M Noor, P H Chuo, S Ishak, S S Anas, S S A Soheimi, R E R Aziddin","doi":"","DOIUrl":"","url":null,"abstract":"Chronic kidney disease (CKD) is a common clinical condition with significant health risks for patients and is widely recognised as a major public health concern. Laboratory medicine plays a crucial role in both diagnosing and managing CKD, as diagnosis and staging rely on estimated glomerular filtration rate (GFR) and evaluating albuminuria (or proteinuria). It was evident that the laboratory assessment of CKD in Malaysia is not standardised. In light of this, the Malaysian Association of Clinical Biochemistry CKD (MACB-CKD) Task Force issued a national recommendation for laboratory diagnosis of CKD in 2019. Recently, Kidney Disease: Improving Global Outcomes (KDIGO) updated its recommendations for the diagnosis, evaluation, management, and treatment of CKD. These guidelines incorporate the most recent evidence-based practices to support laboratory professionals in delivering optimal care for individuals with CKD, focusing on critical areas such as estimated GFR (eGFR), albuminuria assessment, and risk stratification. The latest National Institute for Health and Care Excellence (NICE) guidelines on CKD has also incorporated the Kidney Failure Risk Equation (KFRE) as a tool for predicting the likelihood of progression to end-stage kidney disease (ESKD) in CKD patients. Hence, the MACB-CKD Task Force has reviewed and updated its recommendations for laboratory reporting of eGFR and urine albumin in alignment with the latest guidelines.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"395-400"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts of the 20th Annual Scientific Meeting, College of Pathologists, Academy of Medicine of Malaysia; Bridging Frontiers: Transforming Laboratory Diagnostics for Tomorrow 5th - 6th August 2024, Swiss-Belhotel, Kuantan, Pahang. 马来西亚医学科学院病理学家学院第 20 届科学年会摘要；连接前沿：2024 年 8 月 5-6 日，彭亨州关丹瑞士酒店。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

引用次数: 0

Osteoarthritis: An integrative overview from pathogenesis to management. 骨关节炎：从发病机制到治疗的综合综述。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

W Zhao, Y Long, Y Wang, K Y Chin

引用次数: 0

Surgical ciliated cyst a newly added entity in WHO classification of head and neck tumours (2022): A case report. 外科纤毛囊肿——世卫组织头颈部肿瘤分类中新增的一个实体（2022）：1例报告。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

E P W Hii, C C Tan, Y C Goh, A Ramanathan

{"title":"Surgical ciliated cyst a newly added entity in WHO classification of head and neck tumours (2022): A case report.","authors":"E P W Hii, C C Tan, Y C Goh, A Ramanathan","doi":"","DOIUrl":"","url":null,"abstract":"The surgical ciliated cyst is a newly added entity under the cysts of the jaws in the World Health Organization (WHO) Classification of Head and Neck Tumours (2022). It is preceded by a prior surgery to the jaw many years before its diagnosis. A 53-year-old Chinese female, who had undergone cleft lip and palate repair followed by orthognathic surgery before the age of 20, was referred for management of an incidentally found cyst in the left maxilla. A cone-beam computed tomography revealed a unilocular, well-defined radiolucent lesion periapical to tooth 26. A provisional diagnosis of radicular cyst was given, and the cyst was enucleated under general anaesthesia. Histopathological examination showed a multicystic lesion lined by pseudostratified ciliated columnar epithelium. This case was diagnosed as a surgical ciliated cyst based on the history of previous surgery to the maxillary region, radiographic and histopathological features, which are the three essential features for diagnosis based on the WHO Classification (2022). Surgical ciliated cysts are a rare complication of orthognathic surgery which may be underreported in populations outside Japan. Now that it has been added to the latest WHO Classification, the diagnosis of this entity may be more common than previously reported.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"457-462"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal inflammatory response. 急性绒毛膜羊膜炎伴胎儿炎症反应时，脐静脉内皮细胞中ICAM-1表达上调。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

B S Hanim, Y P Wong, G C Tan, N Abd Shukor

{"title":"ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal inflammatory response.","authors":"B S Hanim, Y P Wong, G C Tan, N Abd Shukor","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: ICAM-1 is an adhesion molecule expressed on the endothelial cells and is involved in regulating leukocyte recruitment to the site of inflammation. Elevated ICAM-1 mRNA expression was found in the serum of mothers with chorioamnionitis. This study aimed to determine the expression of ICAM-1 in the placenta and umbilical cord of pregnancy with chorioamnionitis, and its association with adverse neonatal outcome.Materials and methods: This study comprised a total of 86 cases of which there were 35 cases of non-chorioamnionitis and 51 cases of chorioamnionitis consisting of acute subchorionitis/chorionitis (maternal inflammatory response (MIR) stage 1, n=17), acute chorioamnionitis (MIR stage 2, n=17) and acute necrotising chorioamnionitis (MIR stage 3, n=17). Formalin-fixed paraffin embedded placenta tissue blocks were retrieved from the histopathology archive. ICAM-1 immunohistochemistry was performed on all cases and their expressions were evaluated on cells of the umbilical vein, umbilical artery, foetal vessels and maternal vessels.Results: The expression of ICAM-1 in umbilical vein was significantly associated with cases of foetal inflammatory response (p<0.001).Conclusion: We found that ICAM-1 expression was upregulated in the endothelial cells of umbilical vein in acute chorioamnionitis with positive foetal inflammatory response. ICAM-1 might be involved in the pathogenesis of acute chorioamnionitis and funisitis. Further study using a larger cohort is needed to strengthen this observation.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"423-430"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental finding of intravascular large B cell lymphoma in a multinodular goiter. 在多结节性甲状腺肿中偶然发现血管内大B细胞淋巴瘤。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

N A A Sahmah, K M Y Ling, S N Abdullah Suhaimi, S H Md Pauzi, Y P Wong, G C Tan

引用次数: 0

Beyond platelet production: Megakaryocytes' emerging roles in immunity and infection. 血小板产生之外：巨核细胞在免疫和感染中的新角色。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

R S Y Wong, S K Cheong

引用次数: 0

Abstracts of the International Convention of Forensic Medicine and Sciences 2024: Maintaining Relevance Through Credibility and Continuous Advances, co-organised by Malaysian Society of Forensic Medicine and Science & Queen Elizabeth Hospital, Kota Kinabalu held on 3rd - 5th September 2024. 国际法医学和科学公约2024：通过信誉和持续进步保持相关性，由马来西亚法医学和科学学会和伊丽莎白女王医院共同主办，亚庇京那巴鲁于2024年9月3日至5日举行。