Malaysian Journal of Pathology最新文献_第10页

Distinct microRNA expression pattern in breast cancer cells following anti-neoplastic treatment: A systematic review and functional analysis of microRNA target genes. 抗肿瘤治疗后乳腺癌细胞中不同的microRNA表达模式:microRNA靶基因的系统回顾和功能分析。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

D Qatrun Nada, M L Masniza, N Abdullah, M Marlini, M H Elias, S G Pathmanathan, A R Hayati, F Fadlul Azim, A A Hamid, M M Nur Fariha

{"title":"Distinct microRNA expression pattern in breast cancer cells following anti-neoplastic treatment: A systematic review and functional analysis of microRNA target genes.","authors":"D Qatrun Nada, M L Masniza, N Abdullah, M Marlini, M H Elias, S G Pathmanathan, A R Hayati, F Fadlul Azim, A A Hamid, M M Nur Fariha","doi":"","DOIUrl":"","url":null,"abstract":"Breast cancer remains a significant cause of mortality in females worldwide, despite advances in technology and treatment. MicroRNA expression in breast cancer is studied both as potential biomarkers and for therapeutic purposes. Accumulated evidence revealed microRNA profile of various types of cancer cells following antineoplastic treatment. The progression of research in this area provides better understanding on the anti-cancer mechanism of various natural compounds and drugs specifically on the microRNA regulation. Hence, we aim to systematically review differentially expressed microRNA in MCF-7, a commonly studied breast cancer cell line, after treatment with anti-neoplastic agents. Relevant keywords were used to screen for research articles that reported on the differentially expressed microRNAs in experimental models of MCF-7 before and after anti-neoplastic treatment. Target genes of microRNAs were identified from MiRTarbase and further in silico functional analysis of the target genes were performed using DAVID bioinformatic resources. Two upregulated microRNAs (mir-200c and let-7d) and 3 downregulated microRNAs (mir-27a, mir-27b and mir-203) were identified by highest number of studies. Three microRNAs (let-7a, mir-23a and mir-7) showed inconsistent direction of expression. Genes functional analysis revealed the regulatory effect of microRNA on genes related to angiogenesis, hypoxia, P53, FoxO and PI3K-AKT signalling. Clusters of genes associated to the pathway of angiogenesis, cancers, cell proliferation and apoptosis were noted through protein-protein interaction analysis. MicroRNAs, especially the mir-200c, let-7d, mir-27a, mir-27b and mir-203 from this review could be further validated experimentally to serve as molecular target or biomarkers for anti-neoplastic therapy.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"44 3","pages":"367-385"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10519225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) precipitating unexpected death in an infant: Report of a case and a brief review of literature. 中链酰基辅酶a脱氢酶缺乏症(MCADD)导致婴儿意外死亡:1例报告及文献综述

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

T Kazemi, E Firgau, D Bunch, S B Kahwash

引用次数: 0

Abstracts of the Medical Genetics Conference Kuala Lumpur 2022: The Future is Now: Challenges and Innovative Solutions in Genetic Diagnostics, co-organised by Medical Genetics Society of Malaysia, Chapter of Medical Genetic Pathology, College of Pathologists, Academy of Medicine of Malaysia and Pantai Premier Pathology and held on 7th - 9th September 2022. 吉隆坡2022年医学遗传学会议摘要:未来就是现在:遗传诊断的挑战和创新解决方案，由马来西亚医学遗传学学会，医学遗传病理学分会，病理学家学院，马来西亚医学科学院和Pantai Premier病理学共同组织，于2022年9月7日至9日举行。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

引用次数: 0

Association between bone characteristics and cardiovascular risk factors among adults in selected urban areas in Selangor, Malaysia. 马来西亚雪兰莪州选定城市地区成人骨骼特征与心血管危险因素之间的关系

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

S Mohamad Ismuddin, S C Thambiah, G Appannah, I N Samsudin, S Md Said, S S Yeap, S Y Zahari Sham, F L Hew, P Sthaneshwar

{"title":"Association between bone characteristics and cardiovascular risk factors among adults in selected urban areas in Selangor, Malaysia.","authors":"S Mohamad Ismuddin, S C Thambiah, G Appannah, I N Samsudin, S Md Said, S S Yeap, S Y Zahari Sham, F L Hew, P Sthaneshwar","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Cardiovascular disease and osteoporosis (OP) have been shown to have similar risk factors but studies have demonstrated contradictory results with regards to their associations. This study evaluated relationships between bone characteristics and cardiovascular risk factors among adults in selected urban areas in Malaysia.Materials and methods: A cross-sectional study was performed involving 331 subjects between 45-90 years recruited at a health screening programme. Sociodemographic and clinical characteristics were recorded. Biochemical analyses on fasting blood samples and dual energy X-ray absorptiometry scan to determine bone mineral density (BMD) were performed.Results: Increased waist circumference (WC) was protective for abnormal BMD status (osteopenia and OP). Males with increased high-density lipoprotein cholesterol (HDL) were more likely to be osteoporotic. WC, fasting blood glucose (FBG) and triglyceride (TG) were positively associated with BMD at all sites but was gender specific. In contrast, WC was negatively associated with trabecular bone score (TBS) for females but this association became attenuated when adjusted for fat percentage. HDL and MetS were negatively and positively associated with BMD, respectively in males.Conclusion: The cardiovascular risk factors of raised WC, FBG, TG and low HDL were significantly associated with increased BMD with skeletal site and gender specific differences after adjusting for confounders. However, a higher WC was associated with a weaker skeletal microstructure reflected by lower TBS in females driven by fat percentage. A higher BMD was demonstrated among MetS individuals. These findings suggest that adiposity may have a protective effect on BMD.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"44 3","pages":"477-490"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It is more than uterine fibroids: Incidental discovery of adenoma malignum of the cervix. 它不仅仅是子宫肌瘤:偶然发现的宫颈恶性腺瘤。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

E Abada

{"title":"It is more than uterine fibroids: Incidental discovery of adenoma malignum of the cervix.","authors":"E Abada","doi":"","DOIUrl":"","url":null,"abstract":"Adequate sampling of gross pathology specimens and attention to microscopic details is crucial in establishing the correct diagnosis in a patient, regardless of a benign pre-surgical diagnosis. Adenoma malignum is a rare HPV-negative variant of well-differentiated adenocarcinoma of the endocervix. It is difficult to diagnose in surgical pathology specimens due to its deceptively-benign appearance. This was a case of a 43-year-old woman with a history of menorrhagia and metrorrhagia and radiology interpretation of degenerating uterine fibroids. Pre-operative Pap testing and hysteroscopic dilatation and curettage were non-contributory. Following surgery, microscopic examination of the cervix revealed well-spaced, deeply-invasive, variably-sized glands with irregular outlines/haphazard arrangements, lined by cells showing mild to moderate cytologic atypia. These cells were positive for p53 and CK7 on Immunohistochemistry and Ki-67 showed a high proliferative index. Monoclonal CEA, calretinin, CD10, and P16 were all negative. A diagnosis of adenoma malignum stage pT1b2 was made. The patient was subsequently placed on platinum-based chemotherapy and is doing well 2 years after her diagnosis. Cases such as this, underscore the importance of adequately sampling surgical resection specimens, with careful attention to microscopic details as incidental pathologies may be unearthed which could have significant implications on a patient's clinical outcome.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"44 3","pages":"533-538"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2: Reflection beyond the lungs. SARS-CoV-2:肺部以外的反射。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

G C Tan, Y P Wong

引用次数: 0

The role of peripheral blood smear examination in the evaluation of suspected platelet-related disorders in children: A practical approach and an illustrated review. 外周血涂片检查在评估疑似血小板相关疾病在儿童中的作用:一个实用的方法和说明审查。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

L Tyrrell, M Scruggs, A Kerwin, S B Kahwash

引用次数: 0

Covid-19 variants: Impact on transmissibility and virulence. Covid-19变体:对传播性和毒力的影响

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

Y A Malik

{"title":"Covid-19 variants: Impact on transmissibility and virulence.","authors":"Y A Malik","doi":"","DOIUrl":"","url":null,"abstract":"The genetic evolution of SARS-CoV-2 began in February 2020, with G614 spike protein strains superseding D614 strains globally. Since then with each subsequent mutations, the SARS-CoV-2 variants of concern, namely Alpha, Beta, Gamma, Delta and Omicron, superseded the previous one to become the dominant strain during the pandemic. By the end of November 2022, the Omicron variant and its descendent lineages account for 99.9% of sequences reported globally. All five VOCs have mutations located in the RBD of the spike protein, resulting in increased affinity of the spike protein to the ACE2 receptors resulting in enhanced viral attachment and its subsequent entry into the host cells. In vitro studies showed the mutations in spike protein help increase the viral fitness, enhancing both transmissibility and replication. In general, Alpha, Beta, Gamma, and Delta variants, were reported with higher transmissibility of 43-90%, around 50%, 170-240%, or 130-170% than their co-circulating VOCs, respectively. The Omicron however was found to be 2.38 times and 3.20 times more transmissible than Delta among the fully-vaccinated and boostervaccinated households. Even the SARS-Cov-2 Omicron subvariants appear to be inherently more transmissible than the ones before. With the broader distribution, enhanced evasion, and improved transmissibility, SARS-CoV-2 variants infection cause severe diseases due to immune escape from host immunity and faster replication. Reports have shown that each subsequent VOC, except Omicron, cause increased disease severity compared with those infected with other circulating variants. The Omicron variant infection however, appears to be largely associated with a lower risk of hospitalisation, ICU admission, mechanical ventilation, and even a shorter length of hospital stay. It has been shown that the relatively much slower replication of the Omicron variants in the lung, resulted in a less severe disease.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"44 3","pages":"387-396"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9087713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of mesenchymal stem cells and their derivatives in sarcopenia. 间充质干细胞及其衍生物在肌少症中的治疗潜力。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

R S Y Wong, S K Cheong

引用次数: 0

Cost analysis of pathology services comparing conventional 6-core transrectal biopsy versus transperineal saturation biopsy in diagnosing prostate cancer. 常规6芯经直肠活检与经会阴饱和活检诊断前列腺癌病理服务的成本分析。

IF 1.8 4区医学

Malaysian Journal of Pathology Pub Date : 2022-12-01

J H Tham, L M Looi, R Ghazali

{"title":"Cost analysis of pathology services comparing conventional 6-core transrectal biopsy versus transperineal saturation biopsy in diagnosing prostate cancer.","authors":"J H Tham, L M Looi, R Ghazali","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Patients who are suspected of having prostate cancer from screening tests require a tissue biopsy to confirm the presence of cancer. This study aims to compare the cost and cancer detection rate of two different biopsy protocols: 6-core transrectal (TR) approach, and transperineal (TP) saturation biopsy.Methods: In this descriptive, retrospective study, we selected all prostate biopsies received by the diagnostic pathology department of a tertiary hospital in Malaysia in the year 2020, from adult patients for analysis. Data on demographics, specimen preparation processes, and final histopathological diagnosis was extracted from the Laboratory Information System (LIS). The cost incurred for each biopsy diagnosed as cancer was calculated with the cost prices referenced from laboratory documentation. Statistical analysis was performed using SPSS, version 28.Results: The total cost for detection of cancer using TR biopsy ranged from RM11.22 - RM271.02 with mean of RM47.53. The standard deviation, s is RM43.45. For TP biopsies, the total cost ranged from RM112.20 - RM349.56 with mean of RM160.85, standard deviation of RM80.37. TR biopsies had a detection rate of 43.2%, while TP biopsies had a 24.2% cancer detection rate. There is a 3.38-fold increase in costs between TR and TP biopsy.Conclusion: The results show a 3.38-fold increase in costs and a reduction in cancer detection rate when comparing TR and TP biopsy. The reason for the reduced detection rate is unascertained in this study.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"44 3","pages":"469-475"},"PeriodicalIF":1.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9929962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0