Immunohistochemical expression of CD117 in borderline, low- and high-grade ovarian surface epithelial tumours: A clinicopathological study.

IF 0.6 4区医学 Q4 PATHOLOGY

Malaysian Journal of Pathology Pub Date : 2023-08-01

S A Al-Shami, M M Al-Kaabi, A K Mahdi, Z Al-Attar

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引用次数: 0

Abstract

Introduction: Ovarian cancer is one of leading causes of cancer related death in gynecology. CD117 is a tyrosine kinase receptor that plays an important role in regulation of apoptosis, cell proliferation and adhesion by binding to its ligand-stem cell factor. Recent studies demonstrated its aberrant overexpression in various malignancies and concluded that it may play a pivotal role in carcinogenesis.

Aim: To evaluate CD117 expression in ovarian surface epithelial tumours.

Materials and methods: This retrospective study included 30 ovarian epithelial borderline, low and highly malignant tumours' formalin-fixed paraffin-blocks (FFPE) tissue blocks. Tissue sections were subjected to the routine haematoxylin-eosin stain and with the anti-CD117 immunohistochemically.

Results: There is a high significant difference in CD117 expression between borderline and malignant groups (P = 0.001). Additionally, there was significant difference in expression in relation to histopathological type (serous versus non-serous) in low-grade and the high-grade ovarian surface epithelial tumours (p=0.04, p=0.035 respectively). Tumour grade and stage strongly correlates with CD117 expression (p=0.014, p=0.019 respectively).

Conclusion: We concluded that CD117 expression was significantly correlated with higher ovarian tumour grade and stage.

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CD117在交界性、低级别和高级别卵巢表面上皮肿瘤中的免疫组织化学表达:一项临床病理研究。

卵巢癌是妇科癌症相关死亡的主要原因之一。CD117是一种酪氨酸激酶受体，通过与其配体干细胞因子结合，在细胞凋亡、细胞增殖和粘附调控中发挥重要作用。近年来的研究表明它在多种恶性肿瘤中异常过表达，并认为它可能在癌变中起关键作用。目的:探讨CD117在卵巢表面上皮肿瘤中的表达。材料和方法:回顾性研究了30例卵巢上皮交界性、低恶性和高度恶性肿瘤的福尔马林固定石蜡块(FFPE)组织块。组织切片行常规苏木精-伊红染色和抗cd117免疫组织化学染色。结果:交界性组与恶性组CD117表达差异有显著性意义(P = 0.001)。此外，在低级别和高级别卵巢表面上皮肿瘤中，与组织病理类型(浆液性与非浆液性)相关的表达也有显著差异(p=0.04, p=0.035)。肿瘤分级和分期与CD117表达密切相关(p=0.014, p=0.019)。结论:CD117的表达与卵巢肿瘤的分级和分期有显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Journal of Pathology PATHOLOGY-

CiteScore

3.60

自引率

5.60%

发文量

期刊介绍： The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.