减少马来西亚新生儿浸润性B群链球菌病的策略。

IF 0.6 4区 医学 Q4 PATHOLOGY
Malaysian Journal of Pathology Pub Date : 2025-04-01
N Y Boo
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引用次数: 0

摘要

侵入性新生儿B族链球菌病是全球公认的严重疾病。其最具破坏性的影响是在围产期和产后。来自高收入国家(HICs)的流行病学研究表明,母体直肠阴道GBS定植是主要原因。据估计,全世界有2 000万孕妇患有直肠阴道GBS定植,造成46 200例死产、40 500例侵袭性产妇疾病、231 800例早发性和162 200例晚发性新生儿/婴儿败血症。在从疾病中康复的新生儿/婴儿中,有37,100人患有神经发育障碍。目前HICs的预防措施包括在妊娠35- 37周对母体直肠-阴道GBS定植进行普遍筛查,然后对阳性病例进行产时抗生素预防。这已经预防了80%以上的早发性GBS疾病。在马来西亚的公立医院中,只对曾患围产期GBS感染/疾病的高危妇女进行针对性的母体GBS定植筛查。我们没有关于a)母体GBS直肠阴道定植率,b)由GBS感染引起的死产,c)与母体GBS定植相关的早产,以及d)侵袭性新生儿GBS疾病后神经发育障碍的国家数据。我们只有新生儿GBS败血症的国家数据,其发病率和死亡率都很高。为了减少马来西亚侵入性新生儿GBS疾病,我们需要关于母体GBS直肠阴道定体化患病率、其与死产的相关风险以及GBS相关早产的国家数据,以帮助改进当前的预防策略,以减少围产期和产后侵袭性GBS疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies to reduce invasive neonatal Group B Streptococcal disease in Malaysia.

Invasive neonatal Group B streptococcal (GBS) disease is a globally recognised serious condition. Its most devastating impact is during perinatal and postnatal periods. Epidemiological studies from high-income countries (HICs) showed that maternal rectovaginal GBS colonisation is the leading cause. It was estimated that world-wide, there were 20 million pregnant women with rectovaginal GBS colonisation which has caused 46,200 stillbirths, 40,500 cases of invasive maternal diseases, and 231,800 cases of early-onset and 162,200 cases of late-onset sepsis in neonates/infants. Among neonates/infants who have recovered from the disease, 37,100 suffered neurodevelopmental impairment. The current preventive measures in HICs consist of universal screening for maternal rectovaginal GBS colonisation at 35- to 37-week gestation, followed by intrapartum antibiotic prophylaxis for positive cases. This has prevented more than 80% of early-onset GBS disease. In Malaysian public hospitals, only targeted screening for maternal GBS colonisation was practiced in high-risk women with previous perinatal GBS infection/disease. We do not have national data on a) maternal GBS rectovaginal colonisation rates, b) stillbirths caused by GBS infections, c) preterm birth associated with maternal GBS colonisation, and d) neurodevelopmental impairment following invasive neonatal GBS disease. We only have national data of neonatal GBS sepsis which showed high morbidity and mortality. To reduce invasive neonatal GBS disease in Malaysia, we need national data on the prevalence of maternal GBS rectovaginal colonisation, its associated risk with stillbirths, and GBS-associated preterm births to help improve current preventive strategies to reduce invasive GBS disease during the perinatal and postnatal periods.

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来源期刊
CiteScore
3.60
自引率
5.60%
发文量
34
期刊介绍: The Malaysian Journal of Pathology is the official journal of the College of Pathologists, Academy of Medicine Malaysia. The primary purpose of The Journal is to publish the results of study and research in Pathology, especially those that have particular relevance to human disease occurring in Malaysia and other countries in this region. The term PATHOLOGY will be interpreted in its broadest sense to include Chemical Pathology, Cytology, Experimental Pathology, Forensic Pathology, Haematology, Histopathology, Immunology, Medical Microbiology and Parasitology. The Journal aims to bring under one cover publications of regional interest embracing the various sub-specialities of Pathology. It is expected that the articles published would be of value not only to pathologists, but also to medical practitioners in search of a scientific basis for the problems encountered in their practice, and to those with an interest in diseases which occur in the tropics.
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