Malaysian Journal of Pathology最新文献_第2页

Incidental finding of intravascular large B cell lymphoma in a multinodular goiter.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

N A A Sahmah, K M Y Ling, S N Abdullah Suhaimi, S H Md Pauzi, Y P Wong, G C Tan

引用次数: 0

Abstracts of the International Convention of Forensic Medicine and Sciences 2024: Maintaining Relevance Through Credibility and Continuous Advances, co-organised by Malaysian Society of Forensic Medicine and Science & Queen Elizabeth Hospital, Kota Kinabalu held on 3rd - 5th September 2024.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

引用次数: 0

Beyond platelet production: Megakaryocytes' emerging roles in immunity and infection.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

R S Y Wong, S K Cheong

引用次数: 0

Predatory publishers: Stay vigilant to protect yourself.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

G C Tan

引用次数: 0

Chemoprevention of natural product against oral cancer: A comprehensive review.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

E A Alazazi, A Roslan, F M A Aziz, D Vanoh, A Seeni, S Ahmed, S Munir, J I Mohammad, M D Murtey

{"title":"Chemoprevention of natural product against oral cancer: A comprehensive review.","authors":"E A Alazazi, A Roslan, F M A Aziz, D Vanoh, A Seeni, S Ahmed, S Munir, J I Mohammad, M D Murtey","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Oral cancer is considered the sixth most common form of cancer worldwide. It causes significant morbidity and mortality, especially in low socioeconomic status groups. However, Cancer chemoprevention encompasses the use of specific compounds to suppress the growth of tumours or inhibit carcinogenesis. Natural products have been identified as one of the most significant sources of anti-cancer agents. Meanwhile, several synthetic drugs exhibit potential cytotoxicity and can induce a wide range of degenerative diseases.Aim of the review: This review aims to determine the various plants, vegetables, and fruits possessing natural chemotherapeutic agents against oral cancer cells.Materials and methods: A comprehensive review of findings reported in articles retrieved from searches of computerised databases, hand searches, and authoritative texts. Inclusion databases include PubMed, Medline, Web of Science, Scopus, and Scientific. Exclusion Computerised databases: Wikipedia or unknown sources.Results: Natural products have fewer side effects, high selectivity, low toxicity, and eliminate cancer cells. Thus, the application of natural products as alternative oral and other cancer therapies has recently demonstrated remarkable progress.Conclusion: Natural products have been widely used in developing oral anti-cancer drugs. Most of these natural products present bioactive chemical agents and novel mechanisms of action, such as the inhibition of tumour cell growth, the induction of apoptosis, DNA damage, and the inhibition of topoisomerases I and II. In future, the successful integration of natural products in oral cancer chemoprevention field depends on the advancement of molecular targeting, personalised approaches, and the exploration of novel drug delivery systems. Furthermore, integration of preclinical findings in clinical trials will be important for translating research into impactful interventions.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"355-368"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of novel BCR::ABL1 kinase domain mutation in patients with chronic myeloid leukaemia and imatinib resistance.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

Y M Yusoff, Z A Seman, S Z Anoar, S S M Said, N Azman, N R Kamaluddin, J Abdullah, S S M Yacob, E Esa

{"title":"Identification of novel BCR::ABL1 kinase domain mutation in patients with chronic myeloid leukaemia and imatinib resistance.","authors":"Y M Yusoff, Z A Seman, S Z Anoar, S S M Said, N Azman, N R Kamaluddin, J Abdullah, S S M Yacob, E Esa","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The emergence of mutations in the BCR::ABL1 kinase domain (KD) impairs imatinib mesylate (IM) binding capacity, thus contributing to IM resistance. Identification of these mutations is important for treatment decisions and precision medicine in chronic myeloid leukaemia (CML) patients. Our study aims to determine the frequency of BCR::ABL1 KD mutations in CML patients with IM resistance.Materials and methods: Twenty three CML patients (26.7%) showed to have BCR:ABL1 KD mutations with IM resistance.Results: A total of 14 different types of mutations were identified which are Y253H, E255K, T267A, A287T, M290R, F3111, T3151, F317L, F359V, F3591, F359C, K357T, A399T, E459K and two novel mutations; M290R and K357T. We also discovered two silent mutations at codons 389 and 401.Conclusion: Mutational analysis is recommended to identify patients at risk of disease progression. Therefore, early detection of such mutations may allow timely treatment intervention to prevent or overcome resistance.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"431-439"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolytic measles virus-induced cell killing in radio-resistant and drug-resistant nasopharyngeal carcinoma.

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-12-01

H K Looi, Y F Ngeow, L V Kiew, L Y Chang, H T Ong

{"title":"Oncolytic measles virus-induced cell killing in radio-resistant and drug-resistant nasopharyngeal carcinoma.","authors":"H K Looi, Y F Ngeow, L V Kiew, L Y Chang, H T Ong","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The current first-line therapy for nasopharyngeal carcinoma (NPC) is often associated with long-term complications. Oncolytic measles virus (MV) therapy offers a promising alternative to cancer therapy. This study aims to investigate the efficacy of MV in killing NPC cells in vitro, both with or without resistance to radiation and drug therapy.Materials and methods: NPC cell lines, CNE-1, CNE-2, HONE-1 and C666-1, were exposed to repeated cycles of gamma-irradiation and cisplatin to establish radio- and chemo-resistant cell lines, respectively. The expression of MV receptors, CD46 and nectin-4, were assessed with flow cytometer. To test the efficacy of viral infection, parental and both resistant NPC cells were infected with Measles-GFP-NIS in vitro. The progress of syncytia spread on NPC cells was monitored with fluorescence microscopy up to 60-hours post-infection (p.i.). MV-mediated killing was assessed using tetrazolium-based cell viability assay.Results: We established cisplatin-resistant (CR) NPC cell lines that exhibit more than two-fold shift in IC50 against cisplatin. Only CNE-2 and C666-1 acquired resistant traits after a cumulative 60-Gy gamma irradiation. All untreated parental and resistant NPCs expressed CD46 but not nectin-4 on their cell surface and were susceptible to MV infection. Syncytia were observable as early as 24 hours p.i. and cell loss was observable at 48-hours p.i. onwards. Interestingly, Measles-GFP-NIS shows higher infectivity in NPC with resistance phenotypes, except in CR-C666-1, and were killed more compared to their non-resistant counterparts.Conclusion: Measles-GFP-NIS demonstrated potential as an alternative treatment in relapse, recurrent, or advanced stage NPC which often exhibits resistance towards chemo- and radiotherapy.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 3","pages":"441-451"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The positive impact of Streptococcus mutans on the growth of Candida albicans within mixed-species biofilms and implications to dental health. 变异链球菌对混合菌种生物膜中白色念珠菌生长的积极影响及其对牙齿健康的意义。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-08-01

X Wang, S F Yap, Y F Ngeow

引用次数: 0

Whole genome sequencing reveals the mutational landscape from disease diagnosis to relapse in patients with childhood acute myeloid leukaemia. 全基因组测序揭示了儿童急性髓性白血病患者从疾病诊断到复发期间的突变情况。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-08-01

H Aziz, N S Ab Mutalib, H Alias, R Jamal

{"title":"Whole genome sequencing reveals the mutational landscape from disease diagnosis to relapse in patients with childhood acute myeloid leukaemia.","authors":"H Aziz, N S Ab Mutalib, H Alias, R Jamal","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Leukaemia is the most common cancer in children, however, there is still a big gap in knowledge about the genomic alterations in childhood acute myeloid leukaemia (AML) compared to adult AML. Relapsed AML remains as a leading cause of cancer deaths among children. This study aims to understand the molecular mechanisms of relapsed AML by elucidating the mutational landscape before and during relapse.Materials and methods: Whole genome sequencing was performed on matched samples collected at diagnosis, remission and relapse from three patients of de novo childhood AML. Sanger sequencing was performed for validation in 47 patients' samples, followed by functional analysis.Results: Overall, we identified 312 somatic mutations including synonymous single nucleotide variants (SNVs), missense SNVs, deletions and insertion frameshifts, stopgains and splice sites. After prioritisation, only 46 variants were present at diagnosis (13-17 mutations per patient) and 49 variants at relapse (12-20 mutations per patient). Out of 81 variants, there were 35 new variants detected at relapse but not present at diagnosis. Six potential driver mutations (KIT, CDC73, HNF1A, RBM10, ZMYM4 and ETV6) were identified in predicting relapse for the 3 patients, with recurrent mutations of the ETV6 gene in 2 patients. Functional analysis of the ETV6 mutation showed that ETV6 lost its tumour suppressive function when both mutant ETV6 p.P25fs and ETV6 p.N75fs were tested in vitro.Conclusion: This study has uncovered the mutational landscape in three local childhood AML patients and contributes to a better understanding of the molecular mechanisms of relapsed AML.","PeriodicalId":48723,"journal":{"name":"Malaysian Journal of Pathology","volume":"46 2","pages":"259-278"},"PeriodicalIF":0.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT in pathology. 病理学中的 ChatGPT。

IF 0.6 4区医学

Malaysian Journal of Pathology Pub Date : 2024-08-01

G C Tan, Y P Wong

引用次数: 0