Arab Journal of Gastroenterology最新文献

{"title":"Hsa_circ_0008667 promotes progression and improves the prognosis of gastric cancer by inhibiting miR-9-5p","authors":"Wei Ding ,&nbsp;Zhengliang Li ,&nbsp;Xiaojing Liu ,&nbsp;Jundong Wang ,&nbsp;Jiaxi Wang ,&nbsp;Guoxiang Jiang ,&nbsp;Haizhou Yu ,&nbsp;Tuya Wang","doi":"10.1016/j.ajg.2024.09.002","DOIUrl":"10.1016/j.ajg.2024.09.002","url":null,"abstract":"<div><h3>Background and study aim</h3><div>Gastric cancer (GC) is one of the most common gastrointestinal tumors characterized by aggressive development and poor prognosis. Circular RNAs (circRNAs) have been used as prognostic biomarkers and therapeutic targets in many cancers, including GC. Hsa_circ_0008667 is differentially expressed in GC; however, its function and clinical significance remained unelucidated. Therefore, this study aimed to investigate the role and significance of hsa_circ_0008667 in GC and its potential as a biomarker and therapeutic target of GC.</div></div><div><h3>Patients and methods</h3><div>Through quantitative reverse-transcription real-time PCR, hsa_circ_0008667 expression in GC tissues and cells were analyzed, followed by statistical analyses to assess the clinical significance. Cell Counting Kit-8 and Transwell assays were performed to examine the effects of hsa_circ_0008667 silencing on GC cell growth and metastasis. Additionally, correlation analysis was performed to assess the relationship between hsa_circ_0008667 and miR-9-5p, which was further validated through luciferase reporter assay.</div></div><div><h3>Results</h3><div>Hsa_circ_0008667 was considerably upregulated and tightly correlated with lymph node metastasis and the tumor–node–metastasis stage, which was predictive of poor prognosis in patients with GC. Hsa_circ_0008667 silencing suppressed GC cell proliferation, migration, and invasion. Furthermore, hsa_circ_0008667 negatively regulated miR-9-5p expression. MiR-9-5p downregulation enhanced GC malignancy and reversed hsa_circ_0008667 knockdown-mediated GC suppression.</div></div><div><h3>Conclusion</h3><div>The findings of this study suggest hsa_circ_0008667 to be a prognostic biomarker and tumor promoter of GC via miR-9-5p modulation.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 4","pages":"Pages 349-355"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High frequency of anti-Saccharomyces cerevisiae antibodies in chronic hepatitis C","authors":"Mariam Ghozzi ,&nbsp;Amani Mankai ,&nbsp;Fatma Mechi ,&nbsp;Zeineb Ben Chedly ,&nbsp;Ouafa Kallala ,&nbsp;Sarra Melayah ,&nbsp;Abdelhalim Trabelsi ,&nbsp;Ibtissem Ghedira","doi":"10.1016/j.ajg.2024.07.013","DOIUrl":"10.1016/j.ajg.2024.07.013","url":null,"abstract":"<div><h3>Background and study aim</h3><div>Chronic hepatitis C (CHC) is a liver disease caused by the hepatitis C virus. Anti-<em>Saccharomyces cerevisiae</em> (<em>S. cerevisiae</em>) antibodies (ASCA) are frequently reported in autoimmune diseases but rarely in viral infections. We aimed to determine the frequency of ASCA in adult patients with CHC.</div></div><div><h3>Patients and methods</h3><div>Eighty-eight patients with CHC and 160 healthy blood donors were included in this study. ASCA-IgG and IgA levels were determined using enzyme linked immunosorbent assay. For statistical analysis, we used open EPI version 3 as software. Correlations were determined by Spearman’s test using IBM® SPSS® Statistics.</div></div><div><h3>Results</h3><div>ASCA (IgG or IgA) were present in 31.8 % of patients and in 3.7 % of controls (<em>p</em> &lt; 10⁻⁶). ASCA-IgG and ASCA-IgA were more frequent in patients with CHC than in healthy subjects (23.9 % vs. 3.1 %; <em>p</em> &lt; 10⁻⁵ and 9.1 % vs. 0.6 %; <em>p</em> = 0.002, respectively). In patients, mean levels of ASCA-IgG and IgA were significantly higher than in controls (9.95 ± 11.78 U/mL vs. 2.28 ± 2.86 U/mL, <em>p</em> &lt; 10⁻⁶ and 5.96 ± 7.69 U/mL vs. 0.56 ± 0.12 U/mL, <em>p</em> &lt; 10⁻⁶; respectively). In patients with CHC, the mean level of ASCA-IgG was significantly higher than that of ASCA-IgA (9.95 ± 11.78 U/mL vs. 5.96 ± 7.69 U/mL, <em>p</em> = 0.008).</div></div><div><h3>Conclusion</h3><div>The frequency of ASCA was significantly higher in patients with CHC than in healthy controls.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 4","pages":"Pages 378-382"},"PeriodicalIF":1.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal manifestations in a cohort of pediatric patients with inflammatory bowel disease","authors":"Afroditi Kourti ,&nbsp;Chrysoula Kosmeri ,&nbsp;Aikaterini Chira ,&nbsp;Ino Kanavaki ,&nbsp;Efstathios Stefos ,&nbsp;Periklis Foukas ,&nbsp;Smaragdi Fessatou","doi":"10.1016/j.ajg.2024.05.002","DOIUrl":"10.1016/j.ajg.2024.05.002","url":null,"abstract":"<div><h3>Background and study aims</h3><p>Renal involvement in inflammatory bowel disease is rather uncommon. This study aims to describe the spectrum of renal involvement in pediatric patients with IBD and reduce delay in detection and management.</p></div><div><h3>Patients and methods</h3><p>This is a retrospective study of the renal function of all patients, aged &lt;18 years, who have been followed for IBD in our pediatric gastroenterology department from January 2019 till January 2023.</p></div><div><h3>Results</h3><p><span><span>From the 75 IBD patients included in this study 16 % had renal manifestations. The urinalysis revealed </span>proteinuria<span><span> in 7 patients, proteinuria and hematuria<span><span> in 3 and proteinuria and glycosuria<span> in 2 patients. All 12 patients with abnormal urinalysis underwent further investigation in order to determine the cause of renal damage and the results are as follows: 2 patients had glomerulonephritis and in other 2 patients renal damage was due to medication adverse effect, 1 had pyelonephritis<span> in combination with chronic active tubulointerstitial nephritis and another 1 had </span></span></span>thin basement membrane disease. Three patients had IBD-related dependent renal involvement and 1 resulted in </span></span>chronic renal failure due to </span></span>amyloidosis.</p></div><div><h3>Conclusions</h3><p>It is important for all clinicians to be aware of the possibility of renal manifestations in IBD patients for the early diagnosis and prevention of these manifestations and complications.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 284-287"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between fibrosis-4 score and microvascular complications in patients with type 2 diabetes mellitus","authors":"","doi":"10.1016/j.ajg.2024.04.001","DOIUrl":"10.1016/j.ajg.2024.04.001","url":null,"abstract":"<div><h3>Background and study aims</h3><p><span>Nonalcoholic fatty liver disease is the most prevalent </span>chronic liver disease<span><span><span> globally and is linked to augmented susceptibility to type 2 diabetes mellitus (DM), cardiovascular disease, and </span>microvascular complications<span> inherent to DM, such as nephropathy, </span></span>neuropathy<span>, and retinopathy<span>. The fibrosis-4 (FIB-4) scoring system, a noninvasive tool, is useful for predicting the extent of liver fibrosis across diverse pathologies. This study aimed to assess the potential predictive role of FIB-4 scores in microvascular complications associated with diabetes.</span></span></span></p></div><div><h3>Patients and methods</h3><p><span><span><span>The medical records of patients with type 2 DM admitted to our </span>endocrinology clinic between February 2019 and December 2020 were retrospectively evaluated. Parameters including demographic attributes, fasting </span>blood glucose<span>, glycated hemoglobin, aspartate aminotransferase, </span></span>alanine aminotransferase, thrombocyte levels, and microvascular complications were recorded. The FIB-4 score was computed, and patients were categorized based on these scores (&lt;1.3 and ≥ 1.3).</p></div><div><h3>Results</h3><p><span><span>The analysis included 312 patients with a median age of 60 (50–68 years); 39.7 % were men. The median duration of diabetes was 10 years (5–20 years), and the median FIB-4 score was 0.93 (0.63–1.34). Neuropathy, nephropathy, and retinopathy were observed in 50.6 %, 31.4 %, and 34 % of the patients, respectively. Although the FIB-4 score did not differ significantly between patients with and without </span>neuropathy or retinopathy, patients with nephropathy exhibited higher FIB-4 scores. Notably, patients with FIB-4 scores ≥ 1.3 demonstrated a significantly higher prevalence of nephropathy. </span>Logistic regression analysis demonstrated that higher FIB-4 scores were significantly associated with an increased risk of nephropathy.</p></div><div><h3>Conclusion</h3><p>The FIB-4 score is a cost-effective and straightforward tool with potential applicability in predicting nephropathy in individuals with type 2 DM.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 269-274"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomelanosis of the duodenum and stomach","authors":"","doi":"10.1016/j.ajg.2024.02.002","DOIUrl":"10.1016/j.ajg.2024.02.002","url":null,"abstract":"<div><p><span>Pseudomelanosis duodeni is characterized by endoscopic findings of black or black-brown speckled pigmentation<span><span> in the duodenal mucosa, usually diagnosed via biopsy. This report presents a case of a 75-year-old male presented with left </span>lower abdominal pain<span><span>, change in bowel habits, and </span>decreased appetite<span>. Gastroduodenoscopy and biopsies of the duodenum and </span></span></span></span>antrum lead to the diagnosis of pseudomelanosis duodeni.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 320-322"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of biosimilar infliximab in bio-naïve patients with Crohn’s disease","authors":"","doi":"10.1016/j.ajg.2024.03.006","DOIUrl":"10.1016/j.ajg.2024.03.006","url":null,"abstract":"<div><h3>Background and study aims</h3><p><span><span>The infliximab </span>biosimilar<span> CT-P13 was the first biosimilar </span></span>drug targeting tumor necrosis factor-α. However, its efficacy and safety in real-world clinical situations have remained insufficient. Therefore, we aimed to verify the efficacy and safety of CT-P13 in bio-naïve patients with Crohn’s disease.</p></div><div><h3>Patients and methods</h3><p>This retrospective multicenter study compared the remission rate<span> at week 54 between patients with Crohn’s disease who were treated with originator infliximab or CT-P13. Endoscopic and laboratory findings were assessed in both groups. A total of 184 (156 originator and 28 CT-P13) patients were analyzed. Of these, 138 originator users and 19 biosimilar users completed 54-week administration.</span></p></div><div><h3>Results</h3><p>The clinical remission rates in patients taking originator infliximab of CT-P13 at week 54 were 92.5 % and 100 %, respectively. The endoscopic scores of each group significantly decreased from baseline at week 54 in both groups, and the mucosal healing rate at week 54 was 53 % and 64 %, respectively. Laboratory data including C-reactive protein, serum albumin<span>, and hemoglobin significantly improved from baseline to week 14 and 54 in both groups. Adverse events were observed more frequently in the CT-P13 group (25 % vs. 4.5 %, p = 0.0015), but severe adverse events were rare in both groups.</span></p></div><div><h3>Conclusion</h3><p>The efficacy and safety of CT-P13 were comparable with those of originator infliximab in bio-naïve patients with Crohn’s disease evaluated by clinical, endoscopic, and laboratory findings. This study establishes the needed groundwork for the development of a strategy for treatment with biologics in patients with Crohn’s disease.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 257-262"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma","authors":"ShengJie Dai ,&nbsp;Hongru Kong ,&nbsp;Yang Ja ,&nbsp;Liqi Bao ,&nbsp;Chengchao Wang ,&nbsp;Lei Qin","doi":"10.1016/j.ajg.2024.07.006","DOIUrl":"10.1016/j.ajg.2024.07.006","url":null,"abstract":"<div><h3>Background and study aims</h3><p>Laminin is an extracellular matrix molecule that is the major component of the basement membrane and plays a key role in regulating various processes. However, the association between the laminin gene family and the prognosis of pancreatic carcinoma has not been systematically investigated.</p></div><div><h3>Patients and methods</h3><p>The role of the laminin gene family in pancreatic cancer was evaluated using data from the TCGA database. The effects of different expressions of members of the laminin gene family on pancreatic cancer survival were compared, and their primary cellular roles were examined. The effects of different expressions of positive family genes on proliferation, metastasis, and invasion, as well as EMT and ferroptosis in pancreatic cancer, were also examined.</p></div><div><h3>Results</h3><p>Based on univariate and multifactorial analysis of pancreatic cancer patients, LAMA3 was identified as an independent prognostic factor for overall survival in pancreatic cancer. LAMA3 was found to be enriched in the actin cytoskeleton, P53 signaling pathway, adhesion molecule junctions, pentose phosphate pathway, and regulatory differences in the cell cycle and focal adhesion. Additionally, high expression of LAMA3 was found to promote cancer proliferation, invasion, and metastasis, facilitate the EMT process, and inhibit ferroptosis.</p></div><div><h3>Conclusions</h3><p>Our results identified LAMA3 was associated with the prognosis of patients with pancreatic cancer and may serve as a prognostic biomarker for pancreatic cancer.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 306-314"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1687197924000686/pdfft?md5=ff180492a3408579551251fa9ef12d85&pid=1-s2.0-S1687197924000686-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Helicobacter pylori infection among healthcare workers in Aswan University Hospital","authors":"","doi":"10.1016/j.ajg.2024.01.004","DOIUrl":"10.1016/j.ajg.2024.01.004","url":null,"abstract":"<div><h3>Background and study aim</h3><p><span><span>Helicobacter pylori</span></span> (<em>H. pylori</em><span><span>) is the major pathogen causing upper </span>alimentary tract diseases<span> and has various routes of transmission. It is considered a public health concern owing to its high prevalence. Therefore, proper investigations should be conducted and early treatment modalities developed to avoid its hazardous complications. This study aimed to evaluate the prevalence of </span></span><em>H. pylori</em> infection among healthcare workers (HCWs) in Aswan University Hospital, Aswan Governorate, Egypt.</p></div><div><h3>Patients and methods</h3><p><span>This cross-sectional study was conducted between June and November 2021 and included 200 HCWs who completed a predesigned questionnaire. A serological test was employed to screen for </span><em>H. pylori</em> infection, followed by a stool antigen test for those with positive serology for direction to the associated clinic for therapy.</p></div><div><h3>Results</h3><p>Of the 200 HCWs included in the study, 86 (43 %) were men and 114 (57 %) were women. Their age was 18–58 years. The participants consisted of doctors (31.5 %), nurses (53 %), and workers (15.5 %). The overall prevalence was (58.5 %) of the study participants were seropositive for <em>H. pylori</em> with higher prevalence in women (56.4 %) with no statistical difference (<em>p</em> = 0.841).The age of the participants and work duration exhibited a weak positive correlation with positivity for <em>H. pylori</em> infection (<em>p</em> = 0.033 and <em>p</em> = 0.049, respectively).</p></div><div><h3>Conclusion</h3><p>HCWs are considered to be at a high risk of developing <em>H. pylori</em> infection. Age and work duration were found to contribute to the acquisition of infection. Preventive hospital measures, such as universal precaution, frequent handwashing, and wearing of gloves and a mask/face guard, should be taken to prevent occupational infection.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 250-256"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140945936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image-enhanced endoscopy in intestinal tuberculosis","authors":"Daisuke Murakami ,&nbsp;Yuji Amano ,&nbsp;Makoto Arai","doi":"10.1016/j.ajg.2024.06.004","DOIUrl":"10.1016/j.ajg.2024.06.004","url":null,"abstract":"","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 318-319"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of capsule endoscopy in the phenotype of Crohn’s disease. Data from England 2016–2021","authors":"Priya Oka ,&nbsp;Sophie Vibhishanan ,&nbsp;Stefania Chetcuti Zammit ,&nbsp;Reena Sidhu","doi":"10.1016/j.ajg.2024.06.001","DOIUrl":"10.1016/j.ajg.2024.06.001","url":null,"abstract":"<div><h3>Background and study aims</h3><p>Isolated small bowel Crohn’s disease (SBCD) is reported to have a worse prognosis compared to other CD phenotypes. The aim of this study was to understand the correlation between Isolated SBCD and ileocolonic disease with blood and faecal biomarkers and also to identify differences in outcome and management between the two phenotypes.</p></div><div><h3>Patients and methods</h3><p>Patients with ileocolonic or isolated small bowel Crohn’s Disease (SBCD) were identified from an existing capsule endoscopy (CE) database. Harvey Bradshaw Index (HBI), biomarkers: c-reactive protein (CRP) and faecal calprotectin (FC), Lewis score and findings on CE and subsequent follow up data were collected. SPSS was used to analyse the data.</p></div><div><h3>Results</h3><p>In total 248 patients were included in the study. Patients were split into two groups- Isolated SBCD with 178 patient (median age 44 years (IQR 31–56); 41.5 % male) and Ileocolonic Crohn’s with 70 patients (median age 31 years (IQR 22.7–49); 31.5 % male). A new diagnosis of SBCD was made in 38.7 % (n = 96), whilst 60.0 % (n = 144) had established CD. Patients with ileocolonic disease had a higher HBI in comparison to isolated SBCD [HBI = 7 (IQR 5–10) vs HBI = 6(IQR 4–9); P = 0.04 ]. There was no significant difference in the FC levels between isolated SBCD and ileocolonic disease [136ug/g (IQR 53.8–363.3) vs 171ug/g (IQR 68.5–485.5); p = 0.98]. In isolated SBCD group, 30.3 % (n = 54) CE showed proximal disease, 96 % (n = 171) showed distal disease and 26.4 % (n = 47) showed extensive disease. SBCE was superior to MRI at diagnosing proximal SBCD (P &lt; 0.01). On multivariate logistic regression, we did not identify any predictors of disease severity defined as Lewis score &gt; 790. Following SBCE, 68.5 % (n = 170) of the total patients had a management change. This included commencement or dose escalation of corticosteroids in 123 (49.5 %) patients, azathioprine in 80 (33.3 %) patients, methotrexate in 22 (9.1 %) patients and biological therapy in 110 (44.3 %) patients. HBI predicted a change in management (p &lt; 0.01).</p></div><div><h3>Conclusion</h3><p>CE is an important modality for the diagnosis of active SBCD. It also helps guide treatment in patients identified with active disease.</p></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"25 3","pages":"Pages 288-292"},"PeriodicalIF":1.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}