Arab Journal of Gastroenterology最新文献

Helicobacter pylori and Porphyromonas gingivalis as risk factors in the enteric metaplasia-dysplasia-oncogenesis sequence. 幽门螺杆菌和牙龈卟啉单胞菌是肠化-发育不良-肿瘤发生顺序的危险因素。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-24 DOI: 10.1016/j.ajg.2025.07.001

Jannis Kountouras, Christos Zavos, Stergios A Polyzos, Maria Tzitiridou-Chatzopoulou, Paraskevi Polyzou-Laspia, Dimitrios Chatzopoulos, Michael Doulberis, Elisabeth Vardaka, Ioannis S Papanikolaou

引用次数: 0

The role of salivary calprotectin in monitoring Crohn's disease: A cross-sectional study. 唾液钙保护蛋白在克罗恩病监测中的作用：一项横断面研究。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-23 DOI: 10.1016/j.ajg.2025.08.008

Awni Abu Sneineh, Sara Haj Ali, Maryam Ali Alani, Joud Al Karmi, Feras Al Karmi, Mina F Al-Wandawi, Suzan Al Bdour, Lana Agraib, Rasha Mohammed Ali, Mamoun Ahram

{"title":"The role of salivary calprotectin in monitoring Crohn's disease: A cross-sectional study.","authors":"Awni Abu Sneineh, Sara Haj Ali, Maryam Ali Alani, Joud Al Karmi, Feras Al Karmi, Mina F Al-Wandawi, Suzan Al Bdour, Lana Agraib, Rasha Mohammed Ali, Mamoun Ahram","doi":"10.1016/j.ajg.2025.08.008","DOIUrl":"https://doi.org/10.1016/j.ajg.2025.08.008","url":null,"abstract":"Background and study aims: Noninvasive biomarkers are needed to monitor disease activity in inflammatory bowel disease, as current methods-including blood tests, endoscopy, imaging, and fecal calprotectin-are invasive, costly, or burdensome. This study explored salivary calprotectin as a potential biomarker for Crohn's disease activity.Patients and methods: This was a cross-sectional exploratory study. Unstimulated saliva was collected from patients with an established diagnosis of Crohn's disease and matched healthy controls. Disease activity was determined via the Crohn's disease Activity Index. Salivary calprotectin was measured in 20 μl saliva samples using enzyme-linked immunosorbent assay.Results: Samples were collected from 42 patients with Crohn's disease (mean age 36.3 ± 14.2 years, 52.4 % male) and 41 age-matched healthy controls (mean age 38 ± 13.4 years, 58.5 % male). For patients with Crohn's disease, the median salivary calprotectin level was 0.08 (IQR 0.05-0.14) ug/ml compared to 0.06 (IQR 0.03-0.13) ug/ml in healthy controls (p = 0.161). Among patients with Crohn's disease, levels were similar in remission (0.10, IQR 0.05-0.15 μg/mL) and active disease (0.07, IQR 0.03-0.10 μg/mL; p = 0.091). No correlation was observed between salivary calprotectin and Crohn's disease activity index scores (Spearman's r = -0.136, p = 0.392).Conclusions: Salivary calprotectin did not distinguish patients with Crohn's disease from healthy controls or correlate with disease activity. While noninvasive, it does not appear to be a clinically useful biomarker for monitoring Crohn's disease. Further research may clarify its role in inflammatory bowel disease or identify more promising biomarkers.","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on "Clinical features and temporal trends in H. pylori negative gastric maltoma". 对“幽门螺杆菌阴性胃恶性瘤的临床特征和时间趋势”的评论。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-22 DOI: 10.1016/j.ajg.2025.07.005

Ali Beheshti Namdar, Masoud Keikha

引用次数: 0

Frailty and MASLD in the Arab region: An urgent call for regional clinical and public health strategies. 阿拉伯区域的虚弱和MASLD：紧急呼吁制定区域临床和公共卫生战略。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-22 DOI: 10.1016/j.ajg.2025.07.003

Mohamed El-Kassas, Khalid Alswat, Asma Labidi, Maen Almattooq, Doaa Zakaria, Nabil Debzi, Faisal M Sanai, Mohamed Elbadry, Ali Tumi, Imam Waked, Abdel-Naser Elzouki, Khalid M AlNaamani

引用次数: 0

Investigation of the biomarkers and mechanism based on endoplasmic reticulum stress in irritable bowel syndrome. 肠易激综合征内质网应激的生物标志物及机制研究。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-22 DOI: 10.1016/j.ajg.2025.08.004

Zhenyu Fan, Jiufang Yao, Xiayang Zeng, Jinhong Zuo, Jianpeng Qu

{"title":"Investigation of the biomarkers and mechanism based on endoplasmic reticulum stress in irritable bowel syndrome.","authors":"Zhenyu Fan, Jiufang Yao, Xiayang Zeng, Jinhong Zuo, Jianpeng Qu","doi":"10.1016/j.ajg.2025.08.004","DOIUrl":"https://doi.org/10.1016/j.ajg.2025.08.004","url":null,"abstract":"Background and study aims: Irritable bowel syndrome (IBS) is a common bowel dysfunction disorder. Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several gastrointestinal diseases. This study investigated important ER stress-related genes (ERGs) and their mechanisms of action in IBS.Material and methods: IBS and ERGs data were retrieved from public databases. Differential expression analysis, Venn analysis, and three machine learning algorithms, the most important ERGs in IBS were selected. A nomogram model was then constructed for the clinical predictions based on optimal ERGs. Finally, an LPS-induced Caco-2 cell line was established to simulate intestinal barrier damage and validate the expression of key genes and their underlying mechanisms.Results: Six key ERGs (EGFR, MET, INSR, RETREG1, MCL1, and BSG) were selected to construct the nomogram model, which showed promising clinical predictive performance. These six genes were significantly correlated with immune response and ER stress-related pathways, such as oxidative phosphorylation. In vitro cell experiments have demonstrated damaged barrier function and ER stress activation in IBS, manifesting as lower transepithelial resistance, higher cell permeability, higher levels of inflammatory cytokines, and higher levels of ER proteins in LPS-induced cells. Furthermore, MET expression was significantly increased in the LPS group, whereas EGFR, INSR, RETREG1, MCL1, and BSG levels were significantly decreased in the LPS group.Conclusion: Our study demonstrated a six-gene nomogram model for IBS based on ER stress, which showed a strong relationship between ER stress and various diseases.","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary gastric inflammatory myofibroblastic tumor with liver invasion and metastasis: A case report. 原发性胃炎性肌成纤维细胞瘤伴肝脏侵袭转移1例。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-22 DOI: 10.1016/j.ajg.2025.08.001

Sadullah Şimşek, Mehmet Salih Karaca, Tarık Sağlam, Fatma Şule Kutlar Dursun

引用次数: 0

Effects of oral-gastric treatment and family therapy on H. Pylori eradication and recurrence. 口服胃疗及家庭治疗对幽门螺杆菌根除及复发的影响。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-20 DOI: 10.1016/j.ajg.2025.08.005

Zhiqiang Chen, Fang Yuan, Chao Pan

{"title":"Effects of oral-gastric treatment and family therapy on H. Pylori eradication and recurrence.","authors":"Zhiqiang Chen, Fang Yuan, Chao Pan","doi":"10.1016/j.ajg.2025.08.005","DOIUrl":"https://doi.org/10.1016/j.ajg.2025.08.005","url":null,"abstract":"Background and study aims: Helicobacter pylori (H. pylori) infections are notably difficult to eradicate due to high antibiotic resistance and frequent reinfection. This study evaluates the effectiveness of combining oral and gastric treatments with synchronized family therapy compared to standard therapy for H. pylori management.Patients and methods: Conducted at Cangshan Hospital of the 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, the study included 180 patients divided into three groups: standard triple therapy (Group A), triple therapy plus oral treatment (Group B), and triple therapy with oral treatment and synchronized family therapy (Group C). Eradication and recurrence were measured at 3 and 6 months using stool antigen tests and 14C-urea breath tests.Results: Initial eradication rates were similar across the three groups. By 3 months, eradication rates reached 76.7 % in Group A, 86.7 % in Group B, and 93.3 % in Group C. At 6 months, these rates were 61.7 %, 66.7 %, and 90 %, respectively. Concurrently, recurrence rates at 6 months climbed to 33.9 % and 29.8 % in Groups A and B, respectively, but remained low at 5.3 % in Group C.Conclusion: The addition of synchronized family therapy significantly enhances long-term eradication and reduces recurrence rates, suggesting its potential for incorporation into standard H. pylori treatment protocols.","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular subtypes based on the expression of glutamine metabolism-related genes predict prognosis, tumor microenvironment, and drug therapy response of colon adenocarcinoma. 基于谷氨酰胺代谢相关基因表达的分子亚型预测结肠腺癌的预后、肿瘤微环境和药物治疗反应。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-20 DOI: 10.1016/j.ajg.2025.08.006

Lijian Yu, Xia Lin

{"title":"Molecular subtypes based on the expression of glutamine metabolism-related genes predict prognosis, tumor microenvironment, and drug therapy response of colon adenocarcinoma.","authors":"Lijian Yu, Xia Lin","doi":"10.1016/j.ajg.2025.08.006","DOIUrl":"https://doi.org/10.1016/j.ajg.2025.08.006","url":null,"abstract":"Background and study aims: Glutamine metabolism (GM) plays an instrumental role in the occurrence and progression of tumors. However, the characteristics of glutamine metabolism-related genes (GMRGs) in colon adenocarcinoma (COAD) have not been elucidated. This project aims to dig out the role of GMRGs in COAD molecular subtypes, prognosis, and tumor microenvironment (TME) to proffer a scientific foundation for the evaluation of COAD prognosis and mechanism research.Material and methods: Disease data of COAD (including clinical information and gene expression data) and GMRG data were collected from The Cancer Genome Atlas (TCGA)-COAD. GMRGs in COAD were obtained through differential analysis, cluster analysis, protein-protein interaction (PPI) network analysis, and regression analysis for setting up a prognostic model. Disease information was collected from GSE29621 to validate the model. Differences in immunotherapy response and drug sensitivity among high-Riskscore (HR) and low-Riskscore (LR) groups were evaluated.Results: 45 GMRGs associated with COAD survival rate were identified through univariate analysis. Cluster and survival analyses revealed that these genes could cluster the COAD population into two clusters with great survival differences. A risk model with 10 feature genes was established through regression analysis. Prediction of immunotherapy sensitivity uncovered that the LR group was more sensitive to immunotherapy.Conclusion: In summary, this project set up a reliable prognostic risk model with GMRGs, which can proffer a feasible basis for the study of prognosis and related mechanisms in COAD.","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholecystohepatic duct (type IIIA) - fifth report of aberrant biliary pathology in a paediatric case of oesophageal atresia and imperforate anus with review of literature. 胆囊肝管（IIIA型）：第5例食道闭锁和肛门闭锁的小儿胆道异常病理报告并复习文献。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-20 DOI: 10.1016/j.ajg.2025.07.004

Sushma Achugatla, Rajeev Redkar, Surendra Singh, Sonia Thakur, Jui Mandke

{"title":"Cholecystohepatic duct (type IIIA) - fifth report of aberrant biliary pathology in a paediatric case of oesophageal atresia and imperforate anus with review of literature.","authors":"Sushma Achugatla, Rajeev Redkar, Surendra Singh, Sonia Thakur, Jui Mandke","doi":"10.1016/j.ajg.2025.07.004","DOIUrl":"https://doi.org/10.1016/j.ajg.2025.07.004","url":null,"abstract":"It is known that the presence of associated anomalies has become one of the most critical prognostic factor for infants born with oesophageal atresia (OA). Associated VACTERAL group of abnormalities are common, but other associations are rare. Anomalies of the hepatobiliary system are even more rare among other groups. There are only a few such cases in the literature including adults and paediatric population. We describe the findings and management of one infant born with OA with tracheoesophageal fistula (TEF) and Ano rectal malformation (ARM), who was later shown to have features of obstructive jaundice. The biliary pathology was due to a preoperative diagnosis of Type 1c choledochal cyst, but in reality it was associated with an aberrant form of biliary drainage in the form of cholecystohepatic duct (CCHD). In the English literature, there are only four reported cases of cholecystohepatic duct (CCHD) in children associated with complex congenital anomalies [1-3]. The association of these multiple complex congenital anomalies with aberrant biliary duct is a rare feature. Here, in this case, this aberrant cholecystohepatic duct is the only drainage pathway of bile from liver into gallbladder.","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of primary amelanotic malignant melanoma of esophagus. 食管原发性无黑色素瘤恶性黑色素瘤1例。

IF 1.1 4区医学

Arab Journal of Gastroenterology Pub Date : 2025-09-20 DOI: 10.1016/j.ajg.2025.08.007

Qiqi Ma, Shanbin Wu, Yuting Yang, Sitong Guo, Mei Han, Yan Yan

引用次数: 0