Arab Journal of Gastroenterology最新文献

{"title":"Efficacy of deeper tissue sections for colorectal serrated polyps histologically diagnosed as normal mucosa.","authors":"Masaya Sano, Toshihiro Nishizawa, Osamu Toyoshima, Hidenobu Watanabe, Takuma Hiramatsu, Hiroki Asano, Tomonori Aoki, Keisuke Hata, Hirotoshi Ebinuma, Hidekazu Suzuki","doi":"10.1016/j.ajg.2026.07.008","DOIUrl":"https://doi.org/10.1016/j.ajg.2026.07.008","url":null,"abstract":"<p><strong>Background and study aims: </strong>Discrepancies between endoscopic and histological diagnoses occasionally occur after colorectal polypectomy. This study aimed to evaluate the diagnostic impact of additional histological sections on serrated polyps.</p><p><strong>Patients and methods: </strong>We conducted a retrospective cross-sectional study of resected colorectal polyps between June 2023 and August 2023. Polyps that were endoscopically suspected to be sessile serrated lesions (SSLs) or hyperplastic polyps and resected en bloc were included. Lesions initially diagnosed as normal mucosa were subjected to deeper sectioning and histopathological re-evaluation. Clinicopathological and endoscopic features, including endoscopic SSL diagnosis score, were analysed.</p><p><strong>Results: </strong>Among the 276 eligible lesions, 117 were initially diagnosed as normal mucosa. Deeper sectioning corrected the histopathological diagnosis in 50% of these cases, identifying 5 SSLs and 53 hyperplastic polyps. The lesions reclassified in deeper sections were significantly smaller than those diagnosed in the first sections (P < 0.001). Compared with the \"normal mucosa by first and deeper sections\" group, the \"SSL by deeper section\" group showed significantly higher SSL diagnosis scores, including features such as larger size, mucus cap, and indistinct borders (P < 0.01).</p><p><strong>Conclusions: </strong>Additional histological sectioning significantly improved the diagnostic yield for serrated polyps initially diagnosed as normal mucosa, particularly in small lesions. This effect was most evident in lesions that were ultimately classified as hyperplastic polyps. Endoscopic features suggestive of SSLs were also associated with upgraded diagnoses, although the number of SSL cases was limited.</p>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretation of liver stiffness measurement in patients with mixed liver disease etiologies","authors":"A. El Ray,&nbsp;M. El Ghannam,&nbsp;P.E. Rautou","doi":"10.1016/j.ajg.2026.05.002","DOIUrl":"10.1016/j.ajg.2026.05.002","url":null,"abstract":"<div><div>Vibration-controlled transient elastography (VCTE)–based liver stiffness measurement (LSM) is widely used for non-invasive assessment of liver fibrosis and portal hypertension in chronic liver disease. In daily practice, LSM values are often interpreted using etiology-specific fibrosis cut-offs embedded in device software. However, an increasing proportion of patients now present with mixed liver disease etiologies, particularly combinations of metabolic-associated steatotic liver disease (MASLD) with viral or alcohol-related liver disease. In such patients, applying singleetiology cut-offs may lead to misclassification of fibrosis stage and portal hypertension risk. We highlight the limitations of this approach and argue that LSM should be interpreted within a broader clinical context, integrating platelet count, biochemical markers, and validated risk-stratification algorithms rather than relying solely on fibrosis staging tables.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 448-449"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of positive angiography for non-variceal gastrointestinal bleeding failed to endoscopic diagnosis and treatment","authors":"Jiawei Zhong,&nbsp;Foqiang Liao,&nbsp;Kang Li,&nbsp;Guihai Guo,&nbsp;Youxiang Chen,&nbsp;Xu Shu","doi":"10.1016/j.ajg.2026.06.012","DOIUrl":"10.1016/j.ajg.2026.06.012","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Vascular interventional therapy is considered as a remedial treatment for acute non-variceal gastrointestinal bleeding. For patients failed to endoscopic diagnosis and treatment, the factors that contribute to positive angiography and the risk factors of rebleeding after transcatheter arterial embolization (TAE) have not been fully discussed. The purpose of this present research was to investigate the predictive factors of positive angiography for non-variceal gastrointestinal bleeding failed to endoscopic diagnosis and treatment.</div></div><div><h3>Patients and methods</h3><div>A retrospective study was performed on patients who underwent vascular interventional therapy due to non-variceal gastrointestinal bleeding from January 2014 to December 2021.</div></div><div><h3>Results</h3><div>A total of 71 patients were enrolled, the mean age of these patients was 52.3 ± 18.8 years. There were 41 cases with positive angiography, transcatheter arterial embolization was successfully performed in 38 patients, and the technical success rate was 92.7%. PT &gt;14 s and clip use were independent predictive factors of positive angiography. Blood transfusion unit ≥4u was independent predictor for rebleeding, while the rebleeding rate was lower when transcatheter arterial embolization was successful performed.</div></div><div><h3>Conclusion</h3><div>For patients failed to endoscopic diagnosis and treatment, vascular interventional therapy was an effective remedial treatment option. PT &gt;14 s and clip use were independent predictive factors of positive angiography, and TAE can help reduce the rate of rebleeding.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 391-395"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelin-oligodendrocyte glycoprotein antibody-associated disease in Crohn’s disease: an exceptional neurological manifestation","authors":"Meriem Charifi,&nbsp;Adel Rechach,&nbsp;Mahrez Fissah,&nbsp;Lamia Bengherbia,&nbsp;Mohamed Ouamer Belkacemi,&nbsp;Selma Kesraoui,&nbsp;Ahcene Chibane","doi":"10.1016/j.ajg.2026.02.009","DOIUrl":"10.1016/j.ajg.2026.02.009","url":null,"abstract":"<div><div>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare demyelinating syndrome of the central nervous system (CNS). Its association with other autoimmune diseases is uncommon. We present a unique case of MOGAD in a 53-year-old man with Crohn’s disease, highlighting significant diagnostic challenges. The patient had been diagnosed with Crohn’s disease one year prior, with azathioprine treatment that was ineffective. He underwent surgery for ileal stenosis and an incidental hepatic hydatid cyst. Six weeks later, he developed bilateral optic neuritis and acute myelitis with significant neurologic deficits. After a thorough diagnostic workup and exclusion of other etiologies, including multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD), MOG-IgG seropositivity supported the diagnosis. Immediate high-dose corticosteroid therapy resulted in almost complete recovery of visual and motor functions. This case report highlights the importance of considering rare entities such as MOGAD in patients with Crohn’s disease who present with severe, simultaneous bilateral optic neuritis and myelitis, a core clinical phenotype of MOGAD, even when some imaging features (e.g., orbital MRI) are atypical. Early diagnosis and appropriate management can significantly improve outcomes, as seen in this patient.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 443-447"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of gastric mucosal carcinogenesis-related genes based on cross-sectional multi-stage samples: Expression and functional validation of LILRA4 and IGF2BP3","authors":"Ling Liu,&nbsp;Meng-meng Zhang,&nbsp;Jing Xu,&nbsp;Yan Hu","doi":"10.1016/j.ajg.2026.05.001","DOIUrl":"10.1016/j.ajg.2026.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the key genes differentially expressed across the gastritis-GC spectrum based on multi-stage gastric mucosal samples.</div></div><div><h3>Method</h3><div>Five datasets associated with gastric mucosal carcinogenesis were obtained from the GEO database. DEGs between gastritis and GC were first determined. Four ML models, including LASSO, random Forest, SVM-RFE, and Boruta, were used to screen out DEGs. DCA and ROC analyses were performed to identify the highest discriminative potential model, followed by the identification of hub genes within the highest discriminative potential model. The expression pattern across the gastritis-GC spectrum and the potential pathways of hub genes were then explored. Their expression and prognosis differences in GC were then validated using TCGA data, followed by drug sensitivity assessment. RT-PCR, CCK-8, and transwell assays were used to detect the gene expression, cell viability, invasion, and migration.</div></div><div><h3>Result</h3><div>Among 4 ML models, LASSO with 20 genes was the highest discriminative potential model to distinguish the gastritis from GC. After importance ranking on 20 genes, <em>LILRA4</em> and <em>IGF2BP3</em> were identified as the most important DEGs. Their expressions exhibited an upward trend within the gastritis-GC spectrum. A series of regression analyses, such as ordinal regression, trend regression, and GAM, all confirmed that their expression was significantly higher in GC compared to gastritis. Pathway analysis revealed that they were involved in metabolism and autophagy. <em>LILRA4</em> was associated with GC status and negatively correlated with drug sensitivity. <em>LILRA4</em> or <em>IGF2BP3</em> overexpression promoted GC cell viability, invasion, and migration.</div></div><div><h3>Conclusion</h3><div><em>LILRA4</em> and <em>IGF2BP3</em> may be associated genes differentially expressed across the gastritis-GC spectrum. They may have the potential to screen high-risk groups for GC in patients with gastritis.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 295-310"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of obesity on the outcomes of endoscopic retrograde cholangiopancreatography: A propensity score-matched analysis","authors":"Erfan Arabpour,&nbsp;Amir Sadeghi,&nbsp;Pardis Ketabi Moghadam,&nbsp;Mohammad Abdehagh,&nbsp;Mohammad Reza Zali","doi":"10.1016/j.ajg.2026.06.007","DOIUrl":"10.1016/j.ajg.2026.06.007","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Technical challenges posed by endoscopic retrograde cholangiopancreatography (ERCP) in obese patients are often reflected in longer fluoroscopy and procedure times, which could impact the outcomes of ERCP. This study aims to explore how obesity influences the outcomes of ERCP.</div></div><div><h3>Patients and methods</h3><div>Medical records of patients with a naïve papilla who underwent ERCP between 2021 and 2024 were retrospectively reviewed. Patients were classified into two groups based on body mass index (BMI): non-obese (BMI &lt; 30) and obese (BMI ≥ 30). A 1:1 propensity score matching was performed regarding age, sex, comorbidities, indication, papilla morphology, and cannulation technique. Adverse events, cannulation time and success, and stone clearance were compared between the groups.</div></div><div><h3>Results</h3><div>Of the total 1351 patients, 294 patients were finally included (147 in each group). In the full cohort, procedure stop due to sedation-related adverse events occurred more frequently in the obese group (6.9% vs. 3.3%, <em>p</em>-value = 0.028). In the matched cohort, there was no significant difference in the rate of post-ERCP pancreatitis in obese and non-obese groups (10.2% vs. 17.7%, <em>p</em>-value = 0.06). Stone clearance was achieved in 82.8% and 73.3% of obese and non-obese groups, respectively (<em>p</em>-value = 0.12). There was no significant difference between the groups regarding cannulation time and success (p-value&gt;0.05). Multivariate analysis revealed that BMI was not associated with either PEP (odds ratio = 0.94, 95% confidence interval: 0.87–1.01) or stone clearance success (odds ratio = 0.95, 95% confidence interval: 0.91–1.03).</div></div><div><h3>Conclusions</h3><div>Obesity does not appear to be associated with cannulation challenges, procedure success, and post-ERCP adverse events, although sedation-related adverse events occur more frequently in these patients. However, given the limited sample size, the study may be underpowered to detect modest effects, particularly in patients with BMI ≥35 kg/m².</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 361-368"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular subtyping and therapeutic drug prediction in esophageal squamous cell carcinoma based on manganese-metabolism-related genes","authors":"Long Li,&nbsp;Ying Zhang,&nbsp;Qi Li,&nbsp;Yanli Wu,&nbsp;Guang Chen","doi":"10.1016/j.ajg.2026.07.003","DOIUrl":"10.1016/j.ajg.2026.07.003","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Immunotherapy offers promising prospects for esophageal squamous cell carcinoma (ESCC), a highly fatal malignant tumor. Given the association between manganese metabolism and tumor immunity, this study explored the prognostic value and role of manganese-metabolism-related genes (MMRGs) in the ESCC immune microenvironment to uncover their clinical potential.</div></div><div><h3>Patients and methods</h3><div>Transcriptomic and clinical data of ESCC were retrieved from TCGA and the GEO as training and validation cohorts, respectively. Patients were clustered and subtyped based on MMRGs, with survival compared. A prognostic risk model was constructed using differential analysis, PPI network, and Cox regression; its relationship with immune characteristics, immunotherapy response, and drug sensitivity was evaluated. SLC40A1 was knocked down <em>in vitro</em>, and its effects on cellular function and drug sensitivity were assessed <em>via</em> qRT-PCR, Western blot, colony formation, Transwell, and CCK-8 assays.</div></div><div><h3>Results</h3><div>ESCC patients were stratified into two MMRG-defined subtypes. Cluster 2 showed significantly worse overall survival (OS) than Cluster 1. An 8-gene prognostic model was established and patients were assigned to RiskScore_high and RiskScore_low groups. The high-risk group, characterized by worse OS, displayed an immunosuppressive microenvironment with abundant M2 macrophages and high immune-checkpoint expression (PDCD1, CTLA4, TIGIT), along with a lower TIDE score, suggesting potentially greater benefit from immune-checkpoint blockade. The RiskScore_high group was more sensitive to Gemcitabine and Oxaliplatin, whereas the RiskScore_low group responded better to BI-2536 and NU7441. Cellular functional assays confirmed high expression of SLC40A1 in ESCC cells. SLC40A1 knockdown significantly inhibited cell proliferation, migration, and invasion. Additionally, cells exhibited greater sensitivity to Gemcitabine than to BI-2536.</div></div><div><h3>Conclusion</h3><div>MMRG-based subtyping and the reliable prognostic risk score model provide novel insights for predicting prognosis and developing personalized therapy in ESCC.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 410-424"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic value of heme metabolism-related genes in early-stage hepatocellular carcinoma","authors":"Wenxian Yang,&nbsp;Junbao Wang,&nbsp;Xiaobing Gao,&nbsp;Dexing Chen","doi":"10.1016/j.ajg.2026.04.001","DOIUrl":"10.1016/j.ajg.2026.04.001","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) incidence continues to rise globally, with treatment efficacy constrained by the tumor microenvironment’s high heterogeneity and challenges in early diagnosis. Heme metabolism plays a crucial role in tumor progression, yet its specific function in the development of early-stage HCC remains poorly understood.</div></div><div><h3>Methods</h3><div>This study comprehensively employed univariate and multivariate Cox regression and least absolute shrinkage and selection operator regression models to systematically identify heme metabolism-related genes (HMRGs) significantly associated with early HCC prognosis. Key diagnostic biomarkers were further identified through Support Vector Machine Recursive Feature Elimination and Extreme Gradient Boosting algorithms. Immune microenvironment characteristics were comprehensively analyzed across different prognostic subgroups based on immune infiltration assessment. Additionally, consensus clustering methods revealed molecular subtyping with distinct prognostic features in early-stage HCC.</div></div><div><h3>Results</h3><div>This study identified four key HMRGs as diagnostic genes for early-stage HCC and constructed a robust diagnostic model based on these findings. Additionally, six HMRGs significantly associated with prognosis were screened. Immune infiltration analysis revealed higher Tregs infiltration and lower NK cells infiltration in the high-risk group. Furthermore, consensus clustering analysis divided early-stage HCC into two molecularly heterogeneous subtypes.</div></div><div><h3>Conclusion</h3><div>By systematically analyzing the molecular functions and immune profiles of HMRGs in early-stage HCC, this study contributes to a deeper understanding of its underlying pathology and lays the groundwork for more tailored treatment strategies.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 280-294"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148340769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of HIV, HCV, HBV, and syphilis infection among Egyptian drug users: Cairo University hospitals' experience","authors":"Ahmed Cordie,&nbsp;Rahma Mohamed,&nbsp;Dalia Enaba,&nbsp;Rania Mamdouh,&nbsp;Salma M.A. Mansour,&nbsp;Mirella Sherif,&nbsp;Sara Khalid Kamal,&nbsp;Amal Mohamed Sayed,&nbsp;Gamal Esmat,&nbsp;Ibrahim Ali Kabbash,&nbsp;Hossam Abdelghaffar,&nbsp;Husam Salah Mourad","doi":"10.1016/j.ajg.2026.06.015","DOIUrl":"10.1016/j.ajg.2026.06.015","url":null,"abstract":"<div><h3>Background and study aims</h3><div>An integrated screening program with fast-track access to care for human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), and Syphilis were implemented in substance use treatment clinic at Cairo University hospitals, Egypt. This study aimed to assess seroprevalence rates of HIV, HBV, HCV, and Syphilis among drug users and evaluate their awareness and uptake of prevention and testing services.</div></div><div><h3>Patients and methods</h3><div>A total of 2545 drug users were screened for HIV, HCV, <em>Treponema pallidum</em> (TP) antibodies, and surface antigen of HBV (HBsAg) between September 2022 and January 2024. Additionally, data on knowledge related to testing and prevention services were collected from 1066 drug users.</div></div><div><h3>Results</h3><div>Seroprevalence rates of HIV, HCV, HBsAg, and Syphilis were 4.4%, 8%, 1.34% and 0.1%, respectively. Among the 1066 drug users interviewed regarding their awareness and uptake of prevention and testing services, only 10 (1%) participants were tested for HCV during the previous nationwide screening campaign; three of them tested positive and two received treatment. Five (0.5%) participants were previously tested for HIV and were negative. Only 3 (0.3%) participants had heard of Pre-exposure prophylaxis (PrEP), while 5 (0.5%) received an HBV vaccination. No participants have ever received free condoms, clean needles or methadone maintenance therapy.</div></div><div><h3>Conclusions</h3><div>Our findings indicate the need for improved testing, treatment, and prevention services directed to drug users, coupled with focused awareness efforts to increase access to these services.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 432-437"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation practices during gastrointestinal endoscopy among gastroenterologists: A Nationwide cross-sectional study in Jordan","authors":"Tarek Mazzawi,&nbsp;Ezzat Jaradat,&nbsp;Khaled A. Abukhalaf,&nbsp;Sami Bawardi,&nbsp;Layan Khleifat,&nbsp;Sara Abuazzam,&nbsp;Youmna Abid,&nbsp;Faris Hamoudi,&nbsp;Bara'a AlTa'amreh,&nbsp;Leen Hajahjeh,&nbsp;Faris Allahaseh,&nbsp;Jood Alshaman,&nbsp;Mohammad Al-Khawaldh","doi":"10.1016/j.ajg.2026.06.006","DOIUrl":"10.1016/j.ajg.2026.06.006","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Although benzodiazepines and opioids are commonly used during endoscopy, there is no consensus on an optimal sedation method. However, more physicians prefer propofol for its favored anesthetic properties. This study aimed to compare the sedation regimens used during endoscopy among gastroenterologists in the private and public sectors in Jordan.</div></div><div><h3>Patients and methods</h3><div>A seven-section survey comprising 47 questions was designed to assess sedation practices during esophago-gastro-duodenoscopy (EGD), colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP) and was distributed among Jordanian gastroenterologists.</div></div><div><h3>Results</h3><div>Of 125 gastroenterologists, 113 (90%) participated in this study. Sedation was used less frequently in the public vs. private sector for EGD (47.4% vs. 94.6%, respectively) and colonoscopy (76.3% vs. 97.3%, respectively). However, all patients who underwent ERCP received sedation in both health sectors. Propofol was used at a lower rate in the public sector than in the private sector (44.7% vs. 77.3%, respectively, <em>P</em> &lt; 0.001). Although 31% of gastroenterologists lacked formal sedation training, 93% supported national sedation guidelines.</div></div><div><h3>Conclusions</h3><div>In Jordan, sedation methods used during gastrointestinal endoscopy differ between the public and private sector. Private sector gastroenterologists are more likely to collaborate with anesthesiologists to administer deep sedation and are more satisfied with their sedation regimens than those in the public sector. Standardized protocols and international guidelines are necessary to enhance patient safety and procedural quality.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"27 3","pages":"Pages 353-360"},"PeriodicalIF":1.3,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}