Arab Journal of Gastroenterology最新文献

{"title":"CT and clinical findings of ceftriaxone-associated gallbladder pseudolithiasis","authors":"Ping Xie ,&nbsp;Jingjing Gong ,&nbsp;Xihua Gao ,&nbsp;Chi Xu ,&nbsp;Jinghua Chen ,&nbsp;Yuwen Shen ,&nbsp;Kefu Liu","doi":"10.1016/j.ajg.2025.08.003","DOIUrl":"10.1016/j.ajg.2025.08.003","url":null,"abstract":"<div><h3>Background and study aims</h3><div>To investigate the computed tomography (CT) and clinical findings of ceftriaxone (CTRX)‑associated gallbladder pseudolithiasis (CGPL).</div></div><div><h3>Patients and methods</h3><div>The CT images and clinical data of 85 patients with a history of CTRX treatment from January 2023 to September 2023 were retrospectively analyzed.</div></div><div><h3>Results</h3><div>CGPL was found in 32 of the 85 patients. CGPLs manifested as a sludge pattern in 4 patients, a nodular pattern in 9 patients, and a mud-like pattern in 19 patients. All 4 patients with existing gallbladder lithiasis were found to have CGPL after CTRX treatment. CGPL appeared on the 6th day follow-up CT at the earliest and disappeared on the 30th day follow-up CT at the earliest, CGPL completely disappeared in 12 patients. The total bilirubin level, direct bilirubin level, and albumin/globulin ratio in the patients with CGPL were significantly lower than those in the patients without CGPL; the triglyceride, β2-microglobulin level in the patients with CGPL were significantly higher than those in the patients without CGPL. The dosage and total dose of CTRX up to the first follow-up CT (TD-FFCT) in patients with CGPL were significantly higher than those in patients without CGPL.</div></div><div><h3>Conclusion</h3><div>The most common type of CGPL can be a mud-like pattern, and CGPLs can appear and disappear on the 6th and 30th day follow-up CT. The dosage and TD-FFCT are risk factors for CGPL, as well as existing gallbladder lithiasis. Total bilirubin level, direct bilirubin level, the albumin/globulin ratio, triglyceride level, β2-microglobulin level may have the evaluative value for the formation of CGPL.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 332-336"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of miRNA 221 & miRNA 199-a in the diagnosis of pancreatic adenocarcinoma","authors":"Yosra Ayman Yosry ,&nbsp;Aisha Elsharkawy ,&nbsp;Hussein Hassan Okasha ,&nbsp;Rabab Fouad ,&nbsp;Ahmed Khairy ,&nbsp;Olfat Shaker ,&nbsp;Hany khattab ,&nbsp;Ayman Yosry ,&nbsp;Younan Kabara Ayoub","doi":"10.1016/j.ajg.2025.09.005","DOIUrl":"10.1016/j.ajg.2025.09.005","url":null,"abstract":"<div><h3>Background</h3><div>Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortality, with pancreatic ductal adenocarcinoma (PDAC) being the most common subtype. PDAC is often diagnosed at advanced stages due to lack of symptoms and reliable early biomarkers.</div></div><div><h3>Aim</h3><div>This study aimed to evaluate the diagnostic utility of serum miRNA 221 and miRNA 199-a in PDAC and their association with disease progression. It also examined the correlation of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) with tumor resectability and disease progression.</div></div><div><h3>Methods</h3><div>A total of 110 subjects (55 PDAC and 55 healthy controls) were recruited.Blood samples were collected to measure the serum miRNA 221, serum miRNA 199-a, neutrophil–lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Diagnosis of pancreatic ductal adenocarcinoma (PDAC) was confirmed via endoscopic ultrasound-guided fine needle biopsy (EUS-FNB). Patients were followed for six months to monitor their disease progression.</div></div><div><h3>Results</h3><div>Serum miRNA 221 and miRNA 199-a levels were significantly elevated in pancreatic adenocarcinoma patients (<em>p = 0.009</em> and <em>p = 0.001</em>, respectively), with miRNA 221 correlating with tumor size (r = 0.343, <em>p = 0.01</em>). Advanced tumor stage (T3, T4) was linked to higher miRNA 221 and NLR levels (p = 0.017, <em>p = 0.01</em>). Additionally, lower NLR levels were associated with tumor resectability (<em>p &lt; 0.001</em>) and improved survival (<em>p &lt; 0.001</em>).</div></div><div><h3>Conclusions</h3><div>These findings suggest that miRNA 221 and miRNA 199-a may serve as diagnostic markers for PDAC. While miRNA 221 and NLR are valuable prognostic indicators for tumor progression and patient survival in PDAC. Further validation in larger cohorts and across pancreatic and other gastrointestinal malignancies is needed.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 403-409"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perianal mass: gout as the etiology (with a case report)","authors":"Dan Chen,&nbsp;Xianzhe Wu","doi":"10.1016/j.ajg.2025.09.006","DOIUrl":"10.1016/j.ajg.2025.09.006","url":null,"abstract":"<div><div>Perianal gouty tophi represent a common condition manifesting in a rare site. Due to its rarity in clinical practice, this condition is highly prone to misdiagnosis and inappropriate treatment. This paper presents a detailed report of a middle-aged male patient who was misdiagnosed with perianal abscess. We performed a resection of the perianal mass and debridement and drainage under spinal anesthesia, and the subsequent histopathological examination clearly confirmed the diagnosis of perianal tophi. Conclusion: the perianal masses can also be caused by gout. Although the perianal area is not a common site for tophus formation, in such cases, it is difficult to clearly determine that gout is the cause through common imaging methods such as magnetic resonance imaging (MRI) or ultrasound.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 485-488"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antithrombotic therapy may be associated with earlier colon cancer detection: a retrospective study","authors":"Adonis A. Protopapas ,&nbsp;Vaia Kyritsi ,&nbsp;Eleni Trypaki ,&nbsp;Nefeli Protopapa ,&nbsp;Athanasios Filippidis ,&nbsp;Ioanna Papagiouvanni ,&nbsp;Eleni-Panagiota Chamalidou ,&nbsp;Christos Savopoulos ,&nbsp;Andreas N. Protopapas","doi":"10.1016/j.ajg.2025.09.020","DOIUrl":"10.1016/j.ajg.2025.09.020","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Patients diagnosed with colon cancer after a bleeding episode are often receiving antithrombotic therapy (AT), indicating a potential link between AT and the timing of diagnosis. Our study aims to investigate the possibility that the administration of AT contributes, through the early onset of symptoms, to the early diagnosis of colon cancer.</div></div><div><h3>Patients and methods</h3><div>Patients being treated for colon cancer were analyzed retrospectively. Patients diagnosed after screening colonoscopy or other screening modalities were omitted.</div></div><div><h3>Results</h3><div>171 patients were included. Most patients were diagnosed with cancer stage III (66, 38.6 %) and II (47, 27.5 %). Fifty-five patients were receiving AT (32.2 %), while 54 (31.6) and 44 (25.7) patients presented with a bleeding event or anemia, respectively. A statistically significant association was observed between the use of AT and an earlier cancer stage at diagnosis (p = 0.002). 87.3 % of patients receiving AT were diagnosed with non-metastatic cancer, compared to 67.2 % of patients not receiving AT. Patients diagnosed after a bleeding episode or onset of anemia while receiving AT had an earlier stage of disease at diagnosis than the rest (p &lt; 0.001), with 94.9 % of them being diagnosed with non-metastatic cancer, compared to 68.2 % of patients in other groups.</div></div><div><h3>Conclusions</h3><div>The use of antithrombotic drugs may lead to an earlier diagnosis of colon cancer due to the earlier appearance of complications such as bleeding or anemia. Therefore, the appearance of bleeding in these patients, despite the initial morbidity, may turn out in the long term to be a critical event that allows early diagnosis and treatment.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 458-461"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular subtypes based on the expression of glutamine metabolism-related genes predict prognosis, tumor microenvironment, and drug therapy response of colon adenocarcinoma","authors":"Lijian Yu ,&nbsp;Xia Lin","doi":"10.1016/j.ajg.2025.08.006","DOIUrl":"10.1016/j.ajg.2025.08.006","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Glutamine metabolism (GM) plays an instrumental role in the occurrence and progression of tumors. However, the characteristics of glutamine metabolism-related genes (GMRGs) in colon adenocarcinoma (COAD) have not been elucidated. This project aims to dig out the role of GMRGs in COAD molecular subtypes, prognosis, and tumor microenvironment (TME) to proffer a scientific foundation for the evaluation of COAD prognosis and mechanism research.</div></div><div><h3>Material and methods</h3><div>Disease data of COAD (including clinical information and gene expression data) and GMRG data were collected from The Cancer Genome Atlas (TCGA)-COAD. GMRGs in COAD were obtained through differential analysis, cluster analysis, protein–protein interaction (PPI) network analysis, and regression analysis for setting up a prognostic model. Disease information was collected from GSE29621 to validate the model. Differences in immunotherapy response and drug sensitivity among high-Riskscore (HR) and low-Riskscore (LR) groups were evaluated.</div></div><div><h3>Results</h3><div>45 GMRGs associated with COAD survival rate were identified through univariate analysis. Cluster and survival analyses revealed that these genes could cluster the COAD population into two clusters with great survival differences. A risk model with 10 feature genes was established through regression analysis. Prediction of immunotherapy sensitivity uncovered that the LR group was more sensitive to immunotherapy.</div></div><div><h3>Conclusion</h3><div>In summary, this project set up a reliable prognostic risk model with GMRGs, which can proffer a feasible basis for the study of prognosis and related mechanisms in COAD.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 352-367"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Paediatric autoimmune liver diseases: A descriptive study of patients from Saudi Arabia”. [Arab J. Gastroenterol. 22(2) (2021) 146–150]","authors":"Omar I. Saadah ,&nbsp;Ammar Khayat ,&nbsp;Hadeel A. Alsufyani ,&nbsp;Yagoub Bin-Taleb","doi":"10.1016/j.ajg.2025.08.009","DOIUrl":"10.1016/j.ajg.2025.08.009","url":null,"abstract":"","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Page 500"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori and Porphyromonas gingivalis as risk factors in the enteric metaplasia–dysplasia–oncogenesis sequence","authors":"Jannis Kountouras ,&nbsp;Christos Zavos ,&nbsp;Stergios A. Polyzos ,&nbsp;Maria Tzitiridou-Chatzopoulou ,&nbsp;Paraskevi Polyzou-Laspia ,&nbsp;Dimitrios Chatzopoulos ,&nbsp;Michael Doulberis ,&nbsp;Elisabeth Vardaka ,&nbsp;Ioannis S. Papanikolaou","doi":"10.1016/j.ajg.2025.07.001","DOIUrl":"10.1016/j.ajg.2025.07.001","url":null,"abstract":"","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 318-319"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of pirfenidone and nintedanib in experimental intraabdominal adhesion model","authors":"Olgun Erdem ,&nbsp;Selin Karaman Erdem ,&nbsp;Abdullah Yıldız ,&nbsp;Hakan Çakıt ,&nbsp;Ceren Canbey ,&nbsp;Ömer Faruk Özkan","doi":"10.1016/j.ajg.2025.07.002","DOIUrl":"10.1016/j.ajg.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Postoperative peritoneal adhesions (PPA) develop in up to 90% of intraabdominal surgeries and are a major cause of small bowel obstruction, leading to readmissions and morbidity. However, no effective pharmacologic strategy currently exists for PPA prevention.</div><div>Pirfenidone and Nintedanib are oral antifibrotics approved for idiopathic pulmonary fibrosis, with emerging data on their effects in cardiac and hepatic fibrosis. This study aimed to compare their efficacy in preventing PPA via intraperitoneal (IP) administration in an experimental model.</div></div><div><h3>Methods</h3><div>Twenty-eight rats were randomized into four groups of 7: Pirfenidone (P), Nintedanib (N), combination (P + N), and saline control (C). Adhesions were induced via cecal abrasion. On postoperative day 7, macroscopic fibrosis scores (MFS), affected regions, histopathology, and TGF-β1 expression were evaluated.</div></div><div><h3>Results</h3><div>Group P had significantly lower MFS than Group N (P &lt; 0.001) and showed a reduction trend vs. control. TGF-β1 HScore was significantly lower in Group P vs. Group N (P = 0.002) and P + N (P = 0.014). Group N showed the highest inflammation and elevated TGF-β1 vs. control (P = 0.013).</div></div><div><h3>Conclusion</h3><div>Pirfenidone appears effective in reducing PPA formation via IP administration. In contrast, Nintedanib may be unsuitable for IP use in saline, potentially due to poor solubility.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 322-329"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecystohepatic duct (type IIIA) – fifth report of aberrant biliary pathology in a paediatric case of oesophageal atresia and imperforate anus with review of literature","authors":"Sushma Achugatla ,&nbsp;Rajeev Redkar ,&nbsp;Surendra Singh ,&nbsp;Sonia Thakur ,&nbsp;Jui Mandke","doi":"10.1016/j.ajg.2025.07.004","DOIUrl":"10.1016/j.ajg.2025.07.004","url":null,"abstract":"<div><div>It is known that the presence of associated anomalies has become one of the most critical prognostic factor for infants born with oesophageal atresia (OA). Associated VACTERAL group of abnormalities are common, but other associations are rare. Anomalies of the hepatobiliary system are even more rare among other groups. There are only a few such cases in the literature including adults and paediatric population. We describe the findings and management of one infant born with OA with tracheoesophageal fistula (TEF) and Ano rectal malformation (ARM), who was later shown to have features of obstructive jaundice. The biliary pathology was due to a preoperative diagnosis of Type 1c choledochal cyst, but in reality it was associated with an aberrant form of biliary drainage in the form of cholecystohepatic duct (CCHD). In the English literature, there are only four reported cases of cholecystohepatic duct (CCHD) in children associated with complex congenital anomalies [<span><span>[1]</span></span>, <span><span>[2]</span></span>, <span><span>[3]</span></span>]. The association of these multiple complex congenital anomalies with aberrant biliary duct is a rare feature. Here, in this case, this aberrant cholecystohepatic duct is the only drainage pathway of bile from liver into gallbladder</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 495-499"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of primary amelanotic malignant melanoma of esophagus","authors":"Qiqi Ma ,&nbsp;Shanbin Wu ,&nbsp;Yuting Yang ,&nbsp;Sitong Guo ,&nbsp;Mei Han ,&nbsp;Yan Yan","doi":"10.1016/j.ajg.2025.08.007","DOIUrl":"10.1016/j.ajg.2025.08.007","url":null,"abstract":"<div><div>Primary malignant melanoma of the esophagus (PMME) is an extremely rare malignant tumor. Primary amelanotic malignant melanoma is a subtype of PMME which shows no pigmentation under esophagogastroduodenoscopy (EGD). A lack of understanding of this disease makes it susceptible to misdiagnosis and limits its treatment options. Here, we reported a case which misdiagnosed as esophageal polyps with malignant transformation or esophageal cancer when observed on gastroscopy examination, while proved as primary amelanotic malignant melanoma by immunohistochemistry in our department. The aim of this study is to draw the attention of physicians by describing a case of primary amelanotic malignant melanoma and to aid in the diagnosis of this disease in the future.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 489-494"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}