Arab Journal of Gastroenterology最新文献

{"title":"Prevalence of Blastocystis hominis, Cryptosporidium, and Strongyloidesstercoralis among patients with colorectal carcinoma in Egypt","authors":"Yasmine Gaber ,&nbsp;Noha Madbouly Taha ,&nbsp;Nouran Roby ,&nbsp;Hany William ,&nbsp;Mohamed Mostafa ,&nbsp;Raghda Marzaban","doi":"10.1016/j.ajg.2025.09.003","DOIUrl":"10.1016/j.ajg.2025.09.003","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Colorectal cancer (CRC) is a leading cause of cancer-related death, with strong environmental associations and genetic risk factors. Although some microorganisms have been linked to carcinogenesis in CRC, the prevalence of parasites and their potential role in carcinogenesis remain unclear. This study aimed to determine the prevalence and association of the parasites <em>Blastocystis</em>, <em>Cryptosporidium</em>, and <em>Strongyloides</em> in CRC.</div></div><div><h3>Patients and Methods</h3><div>A case-control study was conducted, including 120 participants, divided into 60 patients with CRC and 60 healthy controls. Patients were recruited from two tertiary care hospitals in Cairo, Egypt. Parasitologic microscopy-based tests for <em>Blastocystis hominis</em> (<em>B. hominis)</em>, <em>Cryptosporidium</em> oocysts, and <em>Strongyloides stercoralis</em> (<em>S. stercoralis)</em> rhabditiform larvae were performed using iodine-stained smears after formol ether concentration, modified Ziehl-Neelsen (MZN) staining, and agar plate culture, respectively.</div></div><div><h3>Results</h3><div><em>Blastocystis</em> and <em>Cryptosporidium</em> were detected at comparable rates in the CRC and control groups (26.7 % vs 28.3 %, p = 0.83 and 8.3 % vs 10 %, p = 0.75, respectively), with no significant association with CRC in terms of site, pattern, histological types, or stages (p = 0.92, 0.88, 0.84, and 0.39, respectively). However, most cases of <em>Blastocystis</em> or <em>Cryptosporidium</em> were observed in localized CRC in the rectum of the adenocarcinoma type. <em>S. stercoralis</em> was not detected in the stool examinations of either patients or controls.</div></div><div><h3>Conclusion</h3><div>None of the parasites studied demonstrated a significant association with CRC when using conventional microscopy-based methods of parasite detection.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 390-394"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of antiviral treatment in Chronic Hepatitis −B (CHB) population","authors":"Tanu Yadav,&nbsp;Suchit Swaroop","doi":"10.1016/j.ajg.2025.09.008","DOIUrl":"10.1016/j.ajg.2025.09.008","url":null,"abstract":"<div><h3>Background</h3><div>CHB causes liver adversity and can be treated by antiviral drugs. HBV-DNA with Liver enzymes, HBeAg and, HBeAb plays a very crucial role in determining whether to provide treatment or not.</div></div><div><h3>Objective</h3><div>This study aimed to derive the prognostic impact of HBeAb on CHB infection and the association between HB viral antigen, HB antibodies, and liver enzymes in providing antiviral treatment to CHB patients.</div></div><div><h3>Methods</h3><div>This study was performed on all HBsAg-positive patients. A data extraction form was prepared to analyse biochemical measures associated with antiviral treatment.</div></div><div><h3>Results</h3><div>An association between antiviral drugs and viral antigens was reported. The average age of participants was 36.89 (± 13.703), and separately, males were 37.64583 (±14.501), and females were 35.2093 (±11.708). Mean of ALT level 105.788 (±239.9647) and AST level 94.775 (± 234.0753). The highest HBeAg positivity was reported at the age of 15–30 years. 0.822 and 0.723p values were reported for the association between ALT, AST serum levels and HBeAg. HBeAg and antiviral therapy show a 0.022 significant value. Regression analysis reported HBeAg with different variables: age<!--> <!-->(<em>p</em> = 0.422),<!--> <!-->gender<!--> <!-->(<em>p</em> = 0.780), ALT<!--> <!-->(<em>p</em> = 0.819), and AST (p = 0.439).</div></div><div><h3>Conclusion</h3><div>Various biomarkers play an important role in treating HBsAg-positive patients. This study stated the pointers to be incorporated during the treatment of HBV patients.</div><div>Abbreviation: HBV, Hepatitis- B Virus; CHB, Chronic Hepatitis-B; HBsAg, Hepatitis-B surface Antigen; HBeAg, Hepatitis-B envelope antigen; HBeAb, Hepatitis-B envelope antibody.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 415-420"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant association of sensitivity to thyroid hormones with liver fibrosis: Analysis based on NHANES data","authors":"Yan Zhao ,&nbsp;Xin-Quan Wu ,&nbsp;Pan Luo ,&nbsp;Shu-Li Liao","doi":"10.1016/j.ajg.2025.09.001","DOIUrl":"10.1016/j.ajg.2025.09.001","url":null,"abstract":"<div><h3>Background and study aims</h3><div>To explore the association between thyroid function and liver fibrosis using the data from the NHANES database.</div></div><div><h3>Patients and methods</h3><div>The data of 5959 participants and 34 variables were obtained. Fibrosis-4 (FIB-4) score was used to assess the liver fibrosis level. LASSO regression analysis was conducted to identify the important thyroid function related indicators and other variables. Logistic and linear regression analyses were used to explore the association between key indicators and FIB-4 score, and their association was then verified by RCS and GAM analyses. The stability of their association was evaluated by trend regression and interaction effect analyses.</div></div><div><h3>Results</h3><div>There were 4652 and 1307 participants in low and high FIB-4 score groups, respectively. LASSO analysis initially identified 17 important variables, of which 4 thyroid indicators were contained including total T3, FT4, TSH, and TT4RI (an index for reflecting sensitivity to thyroid hormones). Of them, TSH and TT4RI showed significant association with liver fibrosis level when FIB-4 was set as categorical (fully adjusted OR_TSH = 1.048 [95 %CI: 1.026, 1.077], P &lt; 0.001; OR _TT4RI = 1.007 [95 %CI: 1.004, 1.011], P &lt; 0.001) or continuous variable (fully adjusted β_TSH = 0.010 [95 %CI: 0.004, 0.015], P = 0.001; β_TT4RI = 0.002 [95 %CI: 0.001, 0.003], P &lt; 0.001). RCS and GAM analyses further supported their association (all fully adjusted P &lt; 0.05). However, fully adjusted trend regression analysis indicated the more stable association of TT4RI with liver fibrosis in a positive relationship (OR_TT4RI = 1.079 [95 %CI: 1.013, 1.150], P = 0.018; β_TT4RI = 0.019 [95 %CI: 0.004, 0.034], P = 0.011). We further found that age, sleep disorder, sodium level, and lymphocyte number had interaction effect with TT4RI (all P for interaction effect &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The sensitivity to thyroid hormones was significantly related to the liver fibrosis, which was more valuable than the common thyroid profile.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 373-382"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of linked-color imaging endoscopy combined with CAD EYE for the detection and characterization of right-sided colon polyps","authors":"Phuoc Huu Tran ,&nbsp;Thi Huyen Thuong Nguyen ,&nbsp;Van Huy Tran","doi":"10.1016/j.ajg.2025.09.016","DOIUrl":"10.1016/j.ajg.2025.09.016","url":null,"abstract":"<div><div>Background and study aims: Optimizing polyp detection, in particular the right-sided colon polyps, is a challenge for endoscopists. This study aimed to evaluate the diagnostic value of LCI combined with CAD EYE in the detection and characterization of right-sided colon polyps.</div></div><div><h3>Patients and methods</h3><div>Patients underwent colonoscopy with WLI up to the cecum and terminal ileum, followed by LCI combined with CAD EYE. All polyps detected were removed and subjected to histological examination.</div></div><div><h3>Results</h3><div>116 patients were enrolled. Out of them, 66 patients had at least one polyp in their right-sided colon. Endoscopy utilizing LCI resulted in a significantly high additional polyp detection rate (APDR) of 25.9 % (95 % CI: 17.6–36.4 %) in the right colon compared to endoscopy with WLI. The APDRs were significantly higher for flat polyps, 43.5 % (95 % CI: 25.6–63.2 %), p = 0.023. The adenoma detection rate (ADR) was also increased, with APDRs for adenomatous polyps and sessile serrated polyps at 30.6 % (95 % CI: 18.0–46.9 %) and 66.7 % (95 % CI: 30–90.3 %), respectively (p = 0.022). The concordance in neoplasia detection utilizing LCI combined with CAD EYE and histological examination demonstrated substantial agreement between the two approaches, with Kappa values of 0.729 (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>LCI combined with CAD EYE emerged as a potential tool for characterizing right-sided colon polyps.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 452-457"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and MASLD in the Arab region: An urgent call for regional clinical and public health strategies","authors":"Mohamed El-Kassas ,&nbsp;Khalid Alswat ,&nbsp;Asma Labidi ,&nbsp;Maen Almattooq ,&nbsp;Doaa Zakaria ,&nbsp;Nabil Debzi ,&nbsp;Faisal M Sanai ,&nbsp;Mohamed Elbadry ,&nbsp;Ali Tumi ,&nbsp;Imam Waked ,&nbsp;Abdel-Naser Elzouki ,&nbsp;Khalid M. AlNaamani","doi":"10.1016/j.ajg.2025.07.003","DOIUrl":"10.1016/j.ajg.2025.07.003","url":null,"abstract":"","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 315-317"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approaches in HELICOBACTER pylori therapy: Clinical trials and advancements in Gastro-Retentive drug delivery systems","authors":"Prachi Pandey ,&nbsp;Debayan Sil ,&nbsp;K.M. Komal ,&nbsp;Manish Kumar","doi":"10.1016/j.ajg.2025.09.010","DOIUrl":"10.1016/j.ajg.2025.09.010","url":null,"abstract":"<div><div><em>HELICOBACTER PYLORI</em> (<em>H. PYLORI</em>) identified in 1982, infects more than half of the world’s population and is a major cause of gastrointestinal issues like gastritis, peptic ulcers, and an elevated risk of stomach cancer. The infection triggers chronic gastritis through the immune response and bacterial toxins such as VacA and CagA, which harm the stomach lining. This persistent inflammation can lead to peptic ulcers by compromising the protective mucous barrier, allowing stomach acid to create lesions. Prolonged infection with more aggressive strains increases the likelihood of gastric cancer by sustaining inflammation and causing genetic changes in stomach cells. Various symptoms related to gastric inflammation include upper abdominal discomfort, bloating, loss of appetite, nausea, and heartburn. The conventional treatment involves a triple therapy regimen combining Rabeprazole, Amoxicillin, and Clarithromycin with the effectiveness of 10-day versus 14-day courses. However, these treatments come with major drawbacks such as quick elimination of a drug from gastrointestinal tract, short half-life and drug resistance. To overcome all these challenges, there is a need for an alternative approach to deliver drugs. In this review, the pathophysiology of <em>H. PYLORI</em> along with its relationship with gut microbe has been discussed. Further, it also includes conventional treatment, its drawbacks and alternative treatment approaches available. Additionally, it also discussed about various clinical trials that have been reported for the treatment of <em>H. PYLORI.</em></div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 473-484"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of SLC22A4 and TNF-α gene polymorphism with susceptibility to inflammatory bowel disease among patients in the Eastern Province of Saudi Arabia","authors":"Sarah M. AlQahtani ,&nbsp;Reema A. Almutairi ,&nbsp;Reem D. Al-Qahtani ,&nbsp;Eman A. BinAqeel ,&nbsp;Chittibabu Vatte ,&nbsp;Cyril Cyrus","doi":"10.1016/j.ajg.2025.09.007","DOIUrl":"10.1016/j.ajg.2025.09.007","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory bowel disease (IBD) is a term referring to gastrointestinal chronic inflammatory disorders. Ulcerative Colitis (UC) and Crohn’s Disease (CD) are the two main types of IBD. The aetiology of such disease has been attributed to many factors: aside from the influence of the environment, genetic factors in particular play a significant role in disease progression. Genetic variants C1672T (SLC22A4), G-207C (SLC22A5) G113A, C4136A, 35delA (DLG5) and (rs1799964) TNF-α have been reported to have significant associations with the development of IBD in various populations.</div></div><div><h3>Aim</h3><div>This study investigated the association of rs1799964 (TNF-α) and rs1050152 (SLC22A4) with IBD risk among patients in Kingdom of Saudi Arabia (KSA).</div></div><div><h3>Methods</h3><div>A study sample (n = 81) was collected from King Fahad University Hospital (KFUH), in the Eastern province of KSA, that included 41 IBD patients (CD = 23, UC = 18) and 40 healthy controls. All subjects were genotyped using real-time PCR based TaqMan chemistry.</div></div><div><h3>Results</h3><div>The results showed that rs1799964 SNP was significantly associated with IBD in terms of C allele frequency (P &lt; 0.0001; OR 11.42, 95 %CI 5.48–23.79) and CC genotype frequency (P &lt; 0.0001; OR 149.5, 95 %CI 15.56–1435.58). A significant association was also found in rs1050152 SNP based on the frequency of the T allele (P &lt; 0.0107; OR 39.94, 95 %CI 2.35–678.43). In terms of genotype frequency, the CT genotype and additive model (CT + TT) were also associated with IBD (p = 0.01).</div><div>Conclusion.</div><div>The significantly associated SNPs of TNF-α and SLC22A4 genes suggest a potential genetic basis for assessing IBD susceptibility in Saudi patients. Further studies from other regions may provide better understanding of disease pathogenesis in relation to genetic association.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 410-414"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the biomarkers and mechanism based on endoplasmic reticulum stress in irritable bowel syndrome","authors":"Zhenyu Fan ,&nbsp;Jiufang Yao ,&nbsp;Xiayang Zeng ,&nbsp;Jinhong Zuo ,&nbsp;Jianpeng Qu","doi":"10.1016/j.ajg.2025.08.004","DOIUrl":"10.1016/j.ajg.2025.08.004","url":null,"abstract":"<div><h3>Background and study aims</h3><div>Irritable bowel syndrome (IBS) is a common bowel dysfunction disorder. Endoplasmic reticulum (ER) stress plays a key role in the pathogenesis of several gastrointestinal diseases. This study investigated important ER stress-related genes (ERGs) and their mechanisms of action in IBS.</div></div><div><h3>Material and methods</h3><div>IBS and ERGs data were retrieved from public databases. Differential expression analysis, Venn analysis, and three machine learning algorithms, the most important ERGs in IBS were selected. A nomogram model was then constructed for the clinical predictions based on optimal ERGs. Finally, an LPS-induced Caco-2 cell line was established to simulate intestinal barrier damage and validate the expression of key genes and their underlying mechanisms.</div></div><div><h3>Results</h3><div>Six key ERGs (EGFR, MET, INSR, RETREG1, MCL1, and BSG) were selected to construct the nomogram model, which showed promising clinical predictive performance. These six genes were significantly correlated with immune response and ER stress-related pathways, such as oxidative phosphorylation. <em>In vitro</em> cell experiments have demonstrated damaged barrier function and ER stress activation in IBS, manifesting as lower transepithelial resistance, higher cell permeability, higher levels of inflammatory cytokines, and higher levels of ER proteins in LPS-induced cells. Furthermore, MET expression was significantly increased in the LPS group, whereas EGFR, INSR, RETREG1, MCL1, and BSG levels were significantly decreased in the LPS group.</div></div><div><h3>Conclusion</h3><div>Our study demonstrated a six-gene nomogram model for IBS based on ER stress, which showed a strong relationship between ER stress and various diseases.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 337-346"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clock is ticking: Early versus delayed laparoscopic cholecystectomy following percutaneous cholecystostomy","authors":"Tolga Canbak ,&nbsp;Mert Gedik ,&nbsp;Kemal Tekeşin ,&nbsp;Abdulbaki Ağaçkıran ,&nbsp;Aylin Acar ,&nbsp;Fatih Başak","doi":"10.1016/j.ajg.2025.09.011","DOIUrl":"10.1016/j.ajg.2025.09.011","url":null,"abstract":"<div><h3>Background</h3><div>The optimal timing for laparoscopic cholecystectomy following percutaneous cholecystostomy remains a subject of considerable debate, and there is conflicting evidence regarding its impact on clinical outcomes. The aim of this retrospective study is to provide evidence-based insights to optimize the management of gallbladder diseases by comparing early versus delayed cholecystectomy after initial percutaneous drainage.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from 43 patients who underwent percutaneous cholecystostomy followed by laparoscopic cholecystectomy between November 2016 and December 2022. The patients were divided into two groups: Group 1 (early cholecystectomy) underwent surgery within eight weeks of cholecystostomy, and Group 2 (delayed cholecystectomy) underwent surgery after eight weeks. We compared the demographic characteristics, comorbidities, conversion rates, and postoperative outcomes between the two groups.</div></div><div><h3>Results</h3><div>No statistically significant differences were found between the two groups in regard to median age, gender distribution, prevalence of comorbidities, or rates of conversion to open surgery (p = 0.999). However, patients in the delayed cholecystectomy group (Group 2) had a higher incidence of high-grade postoperative complications according to the Clavien-Dindo classification.</div></div><div><h3>Conclusion</h3><div>While the overall complication and hospital readmission rates were similar between early and delayed cholecystectomy groups, the observed increase in high-grade complications in the delayed-surgery group underscores the necessity for individualized patient management. <strong>The clock is ticking:</strong> Optimal timing requires a tailored approach that considers patient-specific factors rather than adherence to a rigid timeframe. Larger prospective studies are important for establishing definitive guidelines. Clinicians should employ a multidisciplinary patient-centered strategy to ensure optimal patient outcomes.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 421-424"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of rebamipide quadruple therapy with gastrointestinal endoscopy adjuvant therapy on gastrointestinal hormones in patients with gastric ulcer bleeding","authors":"Jiachen Jing,&nbsp;Jinling Yu,&nbsp;Beina Ji,&nbsp;Jing Guo,&nbsp;Chenlu Li,&nbsp;Zhonghua Cheng","doi":"10.1016/j.ajg.2025.09.013","DOIUrl":"10.1016/j.ajg.2025.09.013","url":null,"abstract":"<div><h3>Background and study aims</h3><div>The study aimed to investigate the effect of rebamipide quadruple therapy combined with gastrointestinal endoscopy on gastrointestinal hormones in patients with gastric ulcer bleeding.</div></div><div><h3>Patients and methods</h3><div>A total of 120 patients with gastric ulcer bleeding were enrolled and randomly assigned into a control group and an observation group, with 60 cases in each group. The control group received rebamipide quadruple therapy, while the observation group received gastrointestinal endoscopy combined with rebamipide therapy. The two groups were compared on general data, therapeutic efficacy, clinical parameters (blood transfusions, hemostasis time, melena relief time, ulcer healing time, and hospitalization duration), coagulation parameters (D-dimer, prothrombin time, activated partial thromboplastin time, fibrinogen), serum levels of gastrin (GAS), motilin (MTL), somatostatin (SS), as well as adverse reactions and re-bleeding rates.</div></div><div><h3>Results</h3><div>The observation group showed a significantly higher clinical efficacy (95.00 %) compared to the control group (80.00 %) (<em>P</em> &lt; 0.05). The observation group had lower blood transfusion volume (401.25 ± 23.57 mL vs. 487.54 ± 30.23 mL), shorter hemostasis time (45.33 ± 9.90 h vs. 51.25 ± 11.62 h), quicker melena remission time (3.37 ± 1.30 d vs. 4.32 ± 1.43 d), faster ulcer healing time (13.73 ± 2.46 d vs. 16.12 ± 3.59 d), and shorter hospitalization time (16.53 ± 2.10 d vs. 19.78 ± 2.47 d) (all <em>P</em> &lt; 0.05). Post-treatment,MTL and GAS levels decreased and SS levels increased in both groups, with the observation group showing significant improvements (<em>P</em> &lt; 0.05). Fib levels also rose in the observation group (3.76 ± 0.31 s vs. 2.64 ± 0.53 s) (<em>P</em> &lt; 0.05). Additionally, D-D, PT, and APTT levels decreased in the observation group and were significantly lower than in the control group (<em>P</em> &lt; 0.05). The observation group had a lower incidence of adverse reactions (8.33 %) and re-bleeding rate (3.33 %) compared to the control group (25.00 % and 16.67 %) (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Rebamipide therapy combined with gastrointestinal endoscopy is an effective treatment for gastric ulcer bleeding and demonstrates a high level of safety.</div></div>","PeriodicalId":48674,"journal":{"name":"Arab Journal of Gastroenterology","volume":"26 4","pages":"Pages 432-436"},"PeriodicalIF":1.1,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}