The role of salivary calprotectin in monitoring Crohn's disease: A cross-sectional study.

IF 1.1 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Awni Abu Sneineh, Sara Haj Ali, Maryam Ali Alani, Joud Al Karmi, Feras Al Karmi, Mina F Al-Wandawi, Suzan Al Bdour, Lana Agraib, Rasha Mohammed Ali, Mamoun Ahram
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引用次数: 0

Abstract

Background and study aims: Noninvasive biomarkers are needed to monitor disease activity in inflammatory bowel disease, as current methods-including blood tests, endoscopy, imaging, and fecal calprotectin-are invasive, costly, or burdensome. This study explored salivary calprotectin as a potential biomarker for Crohn's disease activity.

Patients and methods: This was a cross-sectional exploratory study. Unstimulated saliva was collected from patients with an established diagnosis of Crohn's disease and matched healthy controls. Disease activity was determined via the Crohn's disease Activity Index. Salivary calprotectin was measured in 20 μl saliva samples using enzyme-linked immunosorbent assay.

Results: Samples were collected from 42 patients with Crohn's disease (mean age 36.3 ± 14.2 years, 52.4 % male) and 41 age-matched healthy controls (mean age 38 ± 13.4 years, 58.5 % male). For patients with Crohn's disease, the median salivary calprotectin level was 0.08 (IQR 0.05-0.14) ug/ml compared to 0.06 (IQR 0.03-0.13) ug/ml in healthy controls (p = 0.161). Among patients with Crohn's disease, levels were similar in remission (0.10, IQR 0.05-0.15 μg/mL) and active disease (0.07, IQR 0.03-0.10 μg/mL; p = 0.091). No correlation was observed between salivary calprotectin and Crohn's disease activity index scores (Spearman's r = -0.136, p = 0.392).

Conclusions: Salivary calprotectin did not distinguish patients with Crohn's disease from healthy controls or correlate with disease activity. While noninvasive, it does not appear to be a clinically useful biomarker for monitoring Crohn's disease. Further research may clarify its role in inflammatory bowel disease or identify more promising biomarkers.

唾液钙保护蛋白在克罗恩病监测中的作用:一项横断面研究。
背景和研究目的:需要无创生物标志物来监测炎症性肠病的疾病活动,因为目前的方法——包括血液检查、内窥镜检查、成像和粪便钙保护蛋白——是有创的、昂贵的或负担的。本研究探索唾液钙保护蛋白作为克罗恩病活动性的潜在生物标志物。患者和方法:这是一项横断面探索性研究。从确诊为克罗恩病的患者和匹配的健康对照中收集未受刺激的唾液。通过克罗恩病活动性指数确定疾病活动性。采用酶联免疫吸附法测定20 μl唾液中钙保护蛋白的含量。结果:样本来自42例克罗恩病患者(平均年龄36.3±14.2岁,男性52.4%)和41例年龄匹配的健康对照(平均年龄38±13.4岁,男性58.5%)。克罗恩病患者唾液钙保护蛋白水平中位数为0.08 (IQR 0.05-0.14) ug/ml,而健康对照组为0.06 (IQR 0.03-0.13) ug/ml (p = 0.161)。在克罗恩病患者中,缓解期(0.10,IQR 0.05-0.15 μg/mL)和活动性(0.07,IQR 0.03-0.10 μg/mL, p = 0.091)的水平相似。唾液钙保护蛋白与克罗恩病活动性指数评分无相关性(Spearman’s r = -0.136, p = 0.392)。结论:唾液钙保护蛋白不能区分克罗恩病患者和健康对照者,也不能与疾病活动性相关。虽然无创,但它似乎不是一种临床上有用的监测克罗恩病的生物标志物。进一步的研究可能会阐明其在炎症性肠病中的作用或确定更有希望的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Arab Journal of Gastroenterology
Arab Journal of Gastroenterology Medicine-Gastroenterology
CiteScore
2.70
自引率
0.00%
发文量
52
期刊介绍: Arab Journal of Gastroenterology (AJG) publishes different studies related to the digestive system. It aims to be the foremost scientific peer reviewed journal encompassing diverse studies related to the digestive system and its disorders, and serving the Pan-Arab and wider community working on gastrointestinal disorders.
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