Effects of oral-gastric treatment and family therapy on H. Pylori eradication and recurrence.

Abstract

Background and study aims: Helicobacter pylori (H. pylori) infections are notably difficult to eradicate due to high antibiotic resistance and frequent reinfection. This study evaluates the effectiveness of combining oral and gastric treatments with synchronized family therapy compared to standard therapy for H. pylori management.

Patients and methods: Conducted at Cangshan Hospital of the 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, the study included 180 patients divided into three groups: standard triple therapy (Group A), triple therapy plus oral treatment (Group B), and triple therapy with oral treatment and synchronized family therapy (Group C). Eradication and recurrence were measured at 3 and 6 months using stool antigen tests and 14C-urea breath tests.

Results: Initial eradication rates were similar across the three groups. By 3 months, eradication rates reached 76.7 % in Group A, 86.7 % in Group B, and 93.3 % in Group C. At 6 months, these rates were 61.7 %, 66.7 %, and 90 %, respectively. Concurrently, recurrence rates at 6 months climbed to 33.9 % and 29.8 % in Groups A and B, respectively, but remained low at 5.3 % in Group C.

Conclusion: The addition of synchronized family therapy significantly enhances long-term eradication and reduces recurrence rates, suggesting its potential for incorporation into standard H. pylori treatment protocols.